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ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
Veterans, active military service members and community supporters recently gathered for a hike organized by a nonprofit dedicated to suicide prevention.
Syria’s Democratic Transition: Building Institutions Alongside Political Competition
Syria’s post-Assad transition has revived debate over when to legalize political parties. Parties are essential to political competition,
Florida political leaders mourn after shooting at FAMU homecoming
Florida politicians express grief after a shooting near FAMU homecoming festivities injured multiple people.
On Christ the King and the idolatry of politics
Editor’s note: This homily was preached on the feast of Christ the King (Extraordinary Form), October 25, 2026, at the Church of the Holy Innocents, New York City. In the calendar of the Usus Antiquior, […]
Scientists Found One of The 'Chunkiest' Squid-Like Creatures Ever Known
A "thick and peculiar" cephalopod.
Campbell County health and food inspections (10/16/26–10/22/26)
GILLETTE, Wyo. — The Consumer Health Services Division of the Wyoming Department of Agriculture conducts inspections of retail food establishments throughout Wyoming (where there is not a local health department that does inspections) to help ensure safety of Wyoming residents. Campbell County establishments are inspected at least once a year by the WDA. All of […]
Laramie County health and food inspections (10/16/26–10/22/26)
CHEYENNE, Wyo. — The Cheyenne-Laramie County Health Department inspects restaurants, bars, convenience stores, delis, grocery stores, bed and breakfasts
Natrona County health and food inspections (10/16/26–10/22/26)
CASPER, Wyo. — The Casper-Natrona County Health Department inspects restaurants, grocery stores, convenience stores, mobile food units, commissaries and
Michigan Gov. Gretchen Whitmer says America is ready to elect a Woman
The Michigan governor did not deny that she was exploring a potential run for president in 2028.
Face the Facts: New health insurance helps early childhood educators
Child care is expensive, and keeping qualified workers on the job is part of the challenge. Now, Connecticut is offering a new health insurance subsidy to help early childhood educators lower their monthly premiums. Rep. Kate Farrar (D-West Hartford) explains how it works and why it could make a difference for families. Mike Hydeck: For years, Connecticut has had among…
After Fighting in Gaza and Battling PTSD, Shahar Varon Seeks a Voice In Israel's Mental Health Future
Soldiers and others suffering from post-traumatic stress disorder […]
Obama, in Midwest, assails 'cruelty' and indecency from Trump and his allies in the midterm campaign
Obama remains the Democratic Party’s best motivator nearly a decade after leaving the White House. And he's taking his star power on the road in the final days of the midterm elections, which will help determine the balance of power in American politics on Nov. 3.
World's Fastest Lawnmower Company Is Officially Going Out Of Business
Dixie Chopper made the world's raddest lawnmowers for almost half a century, but its story is now coming to an end.
Grading Iowa Football's Loss To Minnesota
This may have been Iowa's worst quarterback performance since the dreadful 2023 season.
NC business co-owner kills man ‘acting irrationally’ outside Zumba class, police say
A man “acting irrationally” toward patrons of a Zumba fitness class was fatally shot when he turned his attention to an armed business co-owner at the scene, according to investigators in western North Carolina. The confrontation occ…
Amid first 0-3 start since 2007, Giannis-led Heat searching for answers: ‘We’re not in panic mode’
The Heat’s Giannis Antetokounmpo era is off to a rough start.
Instacart Stock What Health Benefits Deal And $5 Million Settlement Mean
Instacart parent Maplebear has agreed to a US$5,000,000 settlement with U.S. authorities over past PERM hiring practices and has been selected by True Rx Health Strategists to power an employer funded healthy food benefit through Instacart Health Fresh Funds starting in 2027. The True Rx program positions Instacart within pharmacy benefit design and ties employer spend directly to clinically supervised food choices. The settlement adds compliance obligations, policy changes and monitoring...
Ranked: Countries With the Most Trust in Science
Discover which countries trust science the most and least in 2025, and how education, religion, and culture shape public confidence.
Halifax Health Sees 19 Biketoberfest-Related Injuries in 2026
With Biketoberfest 2026 having ended on October 18, Daytona Beach’s Halifax Health Medical Center announced the statistics on injuries related to the event. 19 patients were treated for injuries …
Stop Chasing Views: How 87% of Creators Are Using AI to Build Real Businesses Beyond Social Media
87% of creators say AI is growing their business. Here's how creators trade social media algorithms for owned commerce and real enterprises.
LETTER TO THE EDITOR: Misleading political mailer is a smear campaign
The recent misleading smear mailer by the opponents of Denise Krause in the Oregon Senate campaign is the most disgusting exhibit of money and indecency used to capture uninformed voters’ […]
Culture House Wants to Turn Creator Connections Into Lasting Businesses
Culture House connects creators directly with investors and operators, helping turn cultural influence into sustainable businesses.
Investment driving growth at NWS Crane
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Science Snapshots: October 25, 2026
Three key science updates in one minute: Starry Night’s dawn matched to Jul 22, 1889; cold boosts lifespan via BH2/BH4; cluster similar-buildings cools cities.
Liverpool host Brighton; Man Utd take on Bournemouth in PL
2026-10-25T13:33:41ZA rundown of today's games...2pm kick-offs:Liverpool vs BrightonManchester United vs BournemouthHull City vs BrentfordCrystal Palace vs Newcastle4:30pm kick-off:Sunderland vs Leeds...
IU Health’s new downtown medical campus has a name and an opening date
By Daniel Bradley | Indianapolis Business Journal
'All INdiana Politics': Engling, Ballard clash over restoring credibility to Indiana Secretary of State Office
INDIANAPOLIS — On Sunday’s edition of “All INdiana Politics,” Government Reporter Garrett Bergquist sat down with two candidates who are running for secretary of state, Republican Max Engling and independent Greg Ballard. Both candidates outlined contrasting approaches to restore credibility to an office plagued by controversy under outgoing Secretary Diego Morales. They both presented different […]
r/opensource just banned AI, non-English speakers and more
The opensource subreddit’s new rules against AI have sparked a revolt.
Physician Mental Health and Health System Privacy: Why Doctors Avoid Their Own EHR
In most organizations the default access model was built for patient care, not for protecting colleagues. A nurse on another unit, a resident who rotated with them, a department administrator: any of them may technically be able to open the record, even when policy says they should not.
Adam Schiff responds to DOJ’s Alaska threat: ‘it’s Alaska’s business’ to run elections
In an exclusive interview with Meet the Press, Sen. Adam Schiff (D-Calif.) says “it's not the federal government's business to run Alaskan elections,” after the Justice Department sued to block certification of Alaska’s election results if Sen. Dan Sullivan loses, due to another candidate with the same name appearing on the ballot.
Business co-owner kills man ‘acting irrationally’ outside Zumba class, NC police say
The business co-owner was carrying a firearm, Spindale police say.
Business Briefcase: Open-air downtown farm market continues
SHENANDOAH — Schuylkill County’s longest running seasonal outdoor downtown farm market continues its popular run 8 a.m. to noon Tuesdays and Fridays through November along the east side of the first block of South Main Street. Launched in t…
DOE expands tribal energy funding to $125M, selects 63 projects
The Department of Energy expanded a $50 million tribal energy funding opportunity to more than $125 million after tribal applications sought roughly 10 times the initial amount. The agency selected 63 tribe-led projects across 16 states for what it described as the largest single investment in the Office of Indian Energy’s history. The projects include […]
Tickets on sale now for 49 Winchester's Charlottesville show next year
49 Winchester, a homegrown Virginia country rock band, is the first band announced for Ting Pavilion's 2027 lineup. Tickets are on sale now.
‘Dream big’: The Seattle-area kids and teens launching businesses
Some among the Seattle area's Generation Z and Alpha age groups are diving headfirst into entrepreneurship.
How LaLiga Turned a Global Soccer Brand Into an $87 Million U.S. Business
LaLiga’s successful expansion into North America shows how to turn a global sports brand into a sustainable business.
A last-minute voter guide to all 14 propositions on the California ballot
Californians are voting on 14 ballot measures, including propositions on taxes, voting, healthcare, housing and the environment. It's a lot to take in, but we're here to help.
2026 Vanderbilt Football Mailbag #9: Call For Submissions
Post VANDERBILT Football and/or SEC Football questions in the comments here. It’s becoming more and more obvious we’re highly unlikely to win another game this season. Our defensive calls make no sense, we’ve got an uber-talented but uber-raw QB learning on the jerb, and Barton Simmons’ decision to staff our O-Line exclusively with matadors has […]
After win over Ole Miss, Texas QB Arch Manning says that he 'kind of likes being disregarded'
Tune In: Orlando Pride vs Gotham FC on CBS Sports Network
The Pride host Gotham for the final home game of 2026
Detroit Lions updated depth chart: Week 7 vs. Packers
An updated look at the 2026 Detroit Lions’ depth chart ahead of their Week 7 game vs. the Green Bay Packers.
Names in the News: People shaping the future of Lake Area business
The Sculptry promotes staff The Sculptry, Southwest Louisiana’s premier medical aesthetics clinic, has expanded its leadership team with the announcement of new positions for key staff members. Amber Pauley, RN, […]
Arsenal squad & fixtures for the 2026 Messi Cup
The 2026 Messi Cup kicks off on Sunday, with Arsenal’s squad and fixture list for the tournament now confirmed.Photo by Elsa/Getty ImagesThe Arsenal u16s will take part in the Messi Cup this year, w...
What analysts are watching in the Texas Senate race, CBS News political experts weigh in
Bernie Sanders backs Amanda Janoo's health plan
Bernie Sanders joined gubernatorial candidate Amanda Janoo in Winooski to endorse her plan for free universal primary care in Vermont.
A sign of the times? Political sign theft, vandalism pops up in South Bay cities
Each South Bay city has their own rules for where residents put up political signs, and what entities handle theft or vandalism-related incidents.
Interest rates unlikely to reach 4.75% by next summer, say City economists
Experts say Bank of England unlikely to increase rates by full percentage point – and could lower them by end of 2027
Jodi's Journal: The end of an on-air era
Congratulations to a local broadcasting legend as Bill Zortman logs off the air later this week after a 60-year career.
Google’s AI search changes upended online publishing
Some publishers are preparing for a future without Google.
Building bridges that lift us above hate
When Mohammed Al Samawi was growing up in Yemen, the son of a pair of middle-class doctors, teachers taught him that Jews and Christians were enemies destined for hell. “We were trained as children to hate,” he told an audience of some 450 at an antisemitism conference in Denver last week. Like many of his […]
What voters need to know about the races for Florida’s Cabinet positions
The Florida Cabinet consists of the attorney general, chief financial officer and agriculture commissioner.
U of M fellowship aims to boost rural obstetrics training and keep labor and delivery units open
The partnership is launching the new, one-year family medicine obstetrics fellowship next summer to prepare family medicine physicians to provide advanced prenatal, maternity and newborn care in rural communities. The only other fellowship of this kind in Minnesota is at Essentia Health in Duluth.
This Week in Purple: Around The World (Series)
Colorado Rockies news and links for Sunday, October 25th, 2026
Memorial Health dietitian highlights importance of blood sugar management
Zeff encourages people to schedule regular medical appointments and get their blood sugar tested, particularly those with a family history of diabetes.
US employer health insurance premiums exceed $28,000 for family coverage in 2026
US employer health insurance premiums rose 5% in 2026, exceeding $28,000 for family coverage, while nearly half of working-age adults lack adequate coverage
Why do dead bodies move and make noise?
The explanation is less zombie apocalypse and more biology.
Explosion, fire blast through Iowa Quaker Oats plant
An apparent explosion at the Quaker Oats plant in Cedar Rapids sent thick black smoke over downtown Iowa as firefighters battled the massive blaze.
South Texas Health System (@stxhealthsystem)
2 likes, 1 comments - stxhealthsystem on October 25, 2026: "One Last Chance to Think Pink: Breast cancer remains the most common cancer among women after skin cancer, making routine screenings and early detection more important than ever. Mammograms can help identify breast cancer before symptoms appear, when treatment options may be most effective. Last week, South Texas Health System McAllen celebrated breast health and preventive care with a special Mammo Monday event featuring the vibrant sounds of mariachi music at the hospital’s main entrance. The celebration reflected STHS' ongoing commitment to encouraging women to prioritize their health through regular screenings. Now, there’s one final Mammo Monday remaining! Join us at STHS ER Mission on October 26 from 8 a.m. to 5 p.m. for the last breast cancer event of 2026. During the event, attendees can: 🎀 Learn about breast cancer screening options 🎀 Schedule a mammogram appointment 🎀 Receive a complimentary goodie bag while supplies last To help make preventive care more accessible, South Texas Health System is also offering reduced self-pay rates* throughout October: • 2D Mammogram: $100 • 3D Mammogram: $155 • Bone Density Screening: $160 A screening today could make all the difference tomorrow. Make your health a priority and encourage the women you love to do the same. For breast health resources and information on the Think Pink campaign, visit the link in our bio. *If not already a covered benefit of your insurance.".
'Multwoh' becomes highest-grossing film of CinePanalo
'Multwoh,' a queer romance-horror film, has become the highest-grossing film to emerge from the Puregold CinePanalo Film Festival, the film’s team said Sunday.
NFL Week 7 expert picks, predictions: Moneyline, against the spread
A look at our expert picks for Week 7 of the 2026 NFL season.
Sunday Night Football: How to watch the Kansas City Chiefs vs. Seattle Seahawks game tonight
Unfair Links Launches a Link Building Service for Local Backlinks and Google Business Profile Matched Links
Unfair Links Launches a Link Building Service for Local Backlinks and Google Business Profile Matched Links Unfair Links Launches a Link Building Service for Local Backlinks and Google Business Profile Matched Links New York City, USA, Oct. 25, 2026 (GLOBE NEWSWIRE) -- Founded by Rollo Unden and Oliver Fish, Unfair Links builds local backlinks matched to a business's Google Business Profile, country and language, and is now taking sign-ups for its beta waitlist. Unfair Links, a new link building
CEO SUNDAY: Atomic Wings CEO shares his journey from Wall Street to the restaurant business
Atomic Wings CEO Zak Omar shares how his father’s influence, a leukemia diagnosis and a commitment to customer service shaped his path to building a 35-location restaurant chain.
CBS News political experts weigh in on Texas Senate race halfway through early voting
The latest CBS News poll showed Talarico leading 51% to 49%, well within the margin for error.
'Leaky gut' isn’t a medical diagnosis. Here’s what it really means
Here’s what can happen when your intestinal lining becomes inflamed or injured.
Powers Health Community Hospital Achieves Statewide Milestone in Treating Heart Valve Conditions
Powers Health Community Hospital has successfully performed Indiana’s first procedure using the SAPIEN M3™ transcatheter mitral valve replacement (TMVR) system, a minimally invasive treatment for …
Franciscan Health, Tonn and Blank Plan Michigan City Medical Office Building at Former Marquette Mall
Franciscan Health, in partnership with Tonn and Blank Construction, is planning a medical office building on a portion of the former Marquette Mall property. Franciscan Health plans to operate a …
Los Angeles Rams vs. Las Vegas Raiders: How to watch the NFL Week 7 game, channel, streaming info and more
Green Bay Packers vs. Detroit Lions: How to watch the NFL Week 7 game, channel, streaming info and more
Some iPhone Duo displays are cracking, seemingly all in the same way
Following the iPhone Duo launch on Friday, a number of owners are reporting that their inner screens have cracked and...
Cincinnati Bengals vs. Baltimore Ravens: How to watch today, start time, where to stream and more
AV2 Video Codec Adoption Talked Up, SVT-AV2 Being Developed
Back in May the AV2 v1.0 specification was released for this next-generaton, royalty-free video codec
Longview summit to bring together mental health, substance abuse treatment providers - Longview News-Journal
The East Texas Council on Alcoholism and Drug Abuse will bring together mental health experts, substance abuse treatment providers and more during a Nov. 4 conference in Longview. The East […]
Small gyms increase health and connection in rural communities
Within the Adirondacks, outdoor recreation keeps people active. But small gyms popping up encourage indoor activity.
Best AI Tools for Small Business Marketing (2026): CapCut Featured for Creating Professional Video and Visual Content by Expert Consumers
Expert Consumers has recognized CapCut in its 2026 coverage of the best AI tools for small business marketing, highlighting the platform's collection of AI-powered features for creating and editing video, images, audio, and other visual content. The recognition reflects growing interest in tools that support practical marketing activities, including campaign development, promotional content production, and adapting creative assets for different digital channels.
Today on Pinstripe Alley
Heading into the final week with baseball in 2026.
What we learned about our politics in the 2026 Texas elections
From the governor's race to local offices, the culture wars gave way to public education and property taxes.
Election Board: Cognetti makes her case on health care, tariffs and Iran
WILKES-BARRE — Scranton Mayor Paige Cognetti said when she decided to run for Congress, she could not have predicted how much worse things could be across the board.
Better rural health takes more than medical care
Ballad Health connects rural patients to social services, reducing emergency visits and lowering health care costs.
Political attack ads are ugly. We don’t have to be
Political division is testing our character. It is time to trade the anger for kindness and respect.
Health centers brace for new Med-QUEST rules
Starting Jan. 1, most adults enrolled in the government’s Medicaid program will have to show they work, volunteer or go to school part-time at least 80 hours in a month to qualify for healthcare under Med-QUEST, Hawaii’s Medicaid program.
I wish GM, other automakers, would've picked up on hybrids
Freep readers respond to Editorial Page Editor Nancy Kaffer's latest column, Michigan's U.S. Senate race and other news of the week.
Are the Bills playing today? NFL Week 7 schedule, next game, AFC East standings
The Buffalo Bills and star QB Josh Allen are off to a terrific start to the 2026 NFL season. Here's what's on deck for the team in Week 7.
Chicago Bears stadium becomes a political game as midterms near. Can it score for Republicans?
The saga over where the future home of the Chicago Bears has become about more than just sports. For Republicans, and GOP governor nominee Darren Bailey in particular, it represents a political Hail Mary to find a subject that captivates…
Amendment 87 can help support Colorado health care; no to tax increases; and more (Letters)
Amendment 87 gives Colorado a way to respond to our health care affordability crisis. New income tax revenue would be set aside for health care, K-12 public schools, and early child care, with an annual independent audit. For 97% of…
Opinion | Trump Should Stay Out of Brazilian Politics
The president seems not to understand that the global standing of the United States suffers when he plays into the stereotype of the ugly American.
Latino businesses still fearful amid ICE sightings 8 months after Operation Metro Surge
A handful of new Latino eateries have opened on Payne Avenue, as others have slashed hours or remain closed certain weekdays.
How China’s regional leadership changes offer clues to the party’s future
The coming months will see a series of provincial congresses as part of a process that will determine the membership of key party bodies.
New York Giants vs. Houston Texans: How to watch the NFL Week 7 game, channel, streaming info and more
With 52 Businesses Waiting, Charles County Weighs Expanding LaunchPad
LA PLATA, Md. — For dozens of Charles County entrepreneurs, getting a business off the ground includes another hurdle: waiting for a spot in a county training program. Economic development officials told the Charles County commissioners on Tuesday, Oct. 20, that 52 businesses remained on the waiting list for LaunchPad, a pilot program designed to […]
How the Romans Invented Apartment Living. It Was Brilliant, Brutal, and Often Deadly
Long before modern cities built upward, Rome learned how to stack human lives.
Guest Commentary: How anti-Muslim politics endangers every Floridian
The political caricature of Muslims as a national security threat bears little resemblance to the reality that Floridians are living, working, and raising families in peace with nearly half a million Muslims woven into the fabric of the state.
Outside View: Sensible steps on health care caused uproar. Now the numbers are in
By Washington Post Editorial Board
Madison Mayor Drops Reelection Bid, Cites ‘Toxic Political Culture’
The 'price of serving has become too high,' says Mayor Satya Rhodes-Conway.
Pittsburgh Steelers vs. New Orleans Saints: How to watch the NFL international game today, start time, where to stream and more
I filed for bankruptcy after my wife died. Grief hurt my business.
After his wife died from cancer, Brian Rooney struggled to sustain his business while grieving. He filed for Chapter 7 bankruptcy in 2024.