SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " a1 " 25,573 found 🔀 AI-powered Shuffle
How to watch the 2026 WNBA Finals: Golden State Valkyries vs. Atlanta Dream Game 5 time, schedule, where to stream and more
Defender turns striker and scores in Bayern win
Bayern Munich beat Freiburg 3-1 away from home to reclaim top spot in the Bundesliga on Sunday (25).Dayot Upamecano was one of the standout performers, scoring the opener with a move in which he playe...
The Future of IBD Treatment: 4 Promising Therapies to Know About
New treatments are in development for inflammatory bowel diseases like Crohn’s disease and ulcerative colitis. Find out what experts say you should know.
Chris Olave targeted 10 times in Week 7
New Orleans wide receiver Chris Olave went for six receptions for 56 yards on 10 targets in Week 7
Scientists Discover How Excess RNA Can Disrupt the Energy Supply Inside Cells
Scientists at Texas A&M University discovered that excess RNA can interfere with the machinery cells use to produce energy, even without triggering certain immune defenses. The findings reveal an unex...
Sunday Open Thread
There is no Jays news and I’ve got nothing to talk about, so lets have an open thread. We had the second great World Series game in a row last night. I like watching baseball (or any sport) when I have no rooting interest. After a season of caring about every Jays game, I like […]
How Argentina’s Folk Sounds Are Shaping a Generation’s Politics and National Pride
Milo J, Cazzu, and more stars are embracing music and traditions of the Argentine countryside, staving off pop homogenization and sharing their history with the world
Jaylen Warren surpasses 100-yard mark in Week 7
Steelers RB Jaylen Warren rushes for at least 100 yards for third time this season
Oregon fires offensive coordinator Drew Mehringer after team scored just 10 points in loss to Illinois
Saturday's loss marked the third straight game in which Oregon scored under 20 points.
😱Fans back Carrick: How the United players left
Today, Manchester United suffered another crushing defeat, losing 0-3 to Bournemouth at Old Trafford. There was plenty of talk during the week about the rift between the players and Michael Carrick, p...
Police: Lancaster County health care worker assaulted
Incident occurred at WellSpan Hospital in Ephrata Borough, according to police.
Lakers 1st-Round Draft Pick Floated as Trade Piece
The Los Angeles Lakers are off to a fast start. Could it be time to weigh trading away some young pieces to boost the rotation? The post Lakers 1st-Round Draft Pick Floated as Trade Piece appeared first on HEAVY.
Kansas at Duke: Exhibition OGT
Kansas basketball hopes to follow the football team with a win today. Yeah, this game doesn’t count, but any time you’re playing Duke you want to win. Plus, this exhibition game is a big enough deal that ESPN is broadcasting it live (probably because they know everyone else will be watching football. I’m probably going […]
MTSU named among Billboard's Top Music Business Schools for 12th year in a row
Middle Tennessee State University has been named a top music business school by Billboard for the 12th year in a row.MTSU's Department of Recording Industry mad
Giants at Texans live game discussion for Week 7
We, who are about to watch Texans football, salute you.
Astros should stay away from these 2 free agent outfielders
Astros shouldn't be interested in these two outfielders.
Liverpool 2, Brighton 0 – Match Recap: That Was Actually Fun
A look back at the key moments in Liverpool's great victory over Brighton in Premier League action.
Baltimore Ravens vs. Cleveland Bengals Week 6 game discussion
Join the discussion about the Ravens’ Week 7 matchup with the Bengals!
Chair of 'submarine affair' committee probing Netanyahu resigns due to health concerns
***
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Texas Tech Leads 'Bad' Week 8 for Big 12 Unbeatens
The Red Raiders’ playoff dreams hit a wall in Cincinnati as sloppy play and missed opportunities ended their unbeaten run. The Big 12 race is now more open than ever after surprising finishes elsewhere.
Jennifer Hawks explains why she should be California's State Treasurer
Jennifer Hawks, a candidate for California state treasurer, shared her qualifications and vision for the office in an interview on California Politics 360.
Senator, former California Secretary of State Alex Padilla weighs in on voter roll fight
With one week left before the midterm elections, California is facing a federal lawsuit alleging that non-citizens were registered to vote, received mail-in ballots, and, in some cases, voted.
Who can buy California's voter rolls and why?
Chris Micheli, an adjunct professor at McGeorge School of Law and longtime lobbyist, explained who is able to buy the voter rolls and why in an interview on California Politics 360.
Timeline of the Capitol Annex project
Ashley Zavala looked back at the decade-long process of building the new offices for the governor and state lawmakers.
California Politics 360 full episode | Clash over voter rolls heads to court
On Tuesday, one week before the election, a federal judge will determine the next steps.
Cam Skattebo Update: Will Giants Star RB Play Against Texans?
New York Giants share news on RB Cam Skattebo after benching in Week 6. The post Cam Skattebo Update: Will Giants Star RB Play Against Texans? appeared first on HEAVY.
Mystery Ohio news site boosting Ramaswamy's Amy Acton ad tied to California GOP non-profit
As Ohio Republican gubernatorial candidate Vivek Ramaswamy came under fire for releasing an attack ad featuring his Democratic competitor Amy Acton's estranged mother, a mysterious news site was runni...
Wrexham’s Summer Striker Decision Faces Fresh Scrutiny After Blackburn Defeat
Wrexham’s decision to back their current centre-forwards has become a renewed talking point after Saturday’s 2–0 defeat at Blackburn Rovers exposed the gap between attacking activity and a meaningful goal threat.
What Chelsea Did Wrong vs Tottenham
After a stellar run following the international break, things came crashing down for Chelsea as they lost 2-0 to Tottenham Hotspur at the weekend. This marked an extremely rare defeat at Stamford Bridge to the Lilywhites, a crack in a strong record of home wins that has left fans reeling. In this, we will be …
Micron Just Revealed a New Business Strategy. That Change Makes It a Screaming Buy.
Micron is changing more toward contracts, rather than letting the open market dictate pricing.
Mavericks 'Very, Very Confident' in Rookie PG Behind Kyrie Irving
Spanish sensation Sergio de Larrea shined with 21 points against San Antonio, proving he can anchor the rotation while Dallas carefully manages Kyrie Irving’s heavy workload.
10 Thoughts From Watching Others Sweat It Out
Back during the very lean years of the Ray Goff era in Athens, a certain revered columnist for the Macon Telegraph joked in a weekly prediction column that Georgia would lose to “Open” during its upcoming bye week. Thankfully, those years have passed by, and the outlook for Georgia during open weeks for what is […]
NFL Trade Deadline Could Dramatically Change The AFC South Landscape
With top stars from the Titans, Colts, and Jaguars hitting the trade block, Houston’s rivals could strip their rosters of veteran talent to fuel a mid-season rebuild.
Michigan's Jason Beck promised change, but numbers tell another story
Michigan football vowed to fix its perimeter run game or stop it, but the team continues to struggle on the edge.
17 Celebrity Transformations That Left Fans Doing A Double Take
From Avril Lavigne's “soft makeup era” to JoJo Siwa’s “clean girl” aesthetic, these wild celebrity transformations will leave you gagged.
Opinion - How Trump learned to stop worrying and love space science
He recognizes a cool thing when he sees it.
Manchester United vs Bournemouth: Live updates from Old Trafford
Under-fire Manchester United manager Michael Carrick is under enormous pressure heading into today’s Premier League clash with Bournemouth on the back of a seven-game run without a win.The boss has ...
Khaman Maluach: “It’s different. Draymond Green is …
Khaman Maluach: “It’s different. Draymond Green is …
Hints About Why Sabres Missed Connor Hellebuyck
The fact that the Buffalo Sabres missed out on Connor Hellebuyck could linger painfully for a while if the goalie play in Western New York doesn’t improve in a hurry. It’ll hurt all the more because the reports over the summer indicated that for at least a time, the Sabres were the frontrunners to pull […] The post Hints About Why Sabres Missed Connor Hellebuyck appeared first on HEAVY.
Denzel Ward to take part in pregame warmups
Denzel Ward's status for Week 7 remains in question
Liverpool host Brighton; Man Utd take on Bournemouth in PL
2026-10-25T13:33:41ZA rundown of today's games...2pm kick-offs:Liverpool vs BrightonManchester United vs BournemouthHull City vs BrentfordCrystal Palace vs Newcastle4:30pm kick-off:Sunderland vs Leeds...
Health board still paying for research despite criticism over patient benefit
Betsi Cadwaladr health board was due to pay Bangor University £110,686 for two researchers.
NH's Business: Healthcare affordability for NH residents
Fred Kocher sits down with Maria Proulx with Anthem Blue Cross, Blue Shield to talk about healthcare affordability for NH residents.
Will there be VAR for Fleetwood Town vs Arsenal?
The EFL have confirmed the match official appointments for the upcoming round of League Cup fixtures, including Arsenal’s trip away to Fleetwood Town.Photo by George Wood/Getty ImagesThe EFL have co...
Open Thread, Sunday, October 25: How we doing today, folks?
Your daily source for off topic chatter with the MMA Mania faithful.
Iowa Football Was Never Truly A CFP-Caliber Team. The Loss To Minnesota Proved It
The Hawkeyes had plenty of momentum after the Washington game, but there's just too much inconsistency right now. Everything fell apart against Minnesota.
One Underrated Timberwolves Wing Gets High Praise From Chris Finch
Terrence Shannon Jr. is shaping up to be one of the Timberwolves' sneakiest threats.
Guardians Middle Infielder is a Prime Trade Candidate
The Cleveland Guardians, fresh off an ALCS appearance, will be facing several tough decisions next season regarding their lineup. The 85-win team won their division and looks poised to repeat next year, but they face an enviable dilemma. What do they do with their influx of top, young talent, and how do they find them …
How to build a police state
To understand where Trump is trying to take the US, we should look to the authoritarian playbook of his favorite ally: El Salvador’s Nayib Bukele
‘Wicker’ star Alexander Skarsgård says he’s ‘not very good with being earnest’
‘Wicker’ star Alexander Skarsgård says he’s ‘not very good with being earnest,’ which his latest role, as a sexy basket, required.
Will the Brewers lose again this year?
Milwaukee is cooking, y’all. After winning 103 regular season games, they blew through the Padres in the Division Series, swept the Dodgers in 4 games in the Championship Series and currently have a 2-0 lead in the World Series. They’re 5-1 in one-run games, so they’re not exactly blowing teams out. But with their bullpen […]
At Issue: Oct. 25 focuses on political advertisements, Rep. John McGuire candidate profile
In less than two weeks, the votes will be in and you will know who will represent your hometown in Congress. But until then, the political advertisements will target you on every device and platform.
Pair of CBs Lead Steelers Inactives vs. Saints
Terell Smith will have to wait to make his Pittsburgh Steelers debut for at least another week. The fourth-year cornerback, […]
Birmingham City v Charlton Athletic
Follow live text commentary, score updates and match stats from Birmingham City vs Charlton Athletic in the Women's Super League
2026 Vanderbilt Football Mailbag #9: Call For Submissions
Post VANDERBILT Football and/or SEC Football questions in the comments here. It’s becoming more and more obvious we’re highly unlikely to win another game this season. Our defensive calls make no sense, we’ve got an uber-talented but uber-raw QB learning on the jerb, and Barton Simmons’ decision to staff our O-Line exclusively with matadors has […]
McMillan backs Coombes after groin grab allegation
Munster head coach Clayton McMillan backs Gavin Coombes after the back row alleged he had been grabbed in the groin in Saturday's defeat by Leinster.
My mom put college on hold to raise me. We graduated together.
My mom put college on hold to raise me and my brother. In 2026, we both graduated, and I couldn't be prouder of what she accomplished.
A doctor traded health insurance for direct primary care, cost-sharing
A doctor explains why he replaced traditional health insurance for his family of four with direct primary care and a medical cost-sharing group.
Week 7 inactives for Saints
New Orleans declares seven players inactive versus Pittsburgh
Interest rates unlikely to reach 4.75% by next summer, say City economists
Experts say Bank of England unlikely to increase rates by full percentage point – and could lower them by end of 2027
Patriots rooting guide for NFL Week 7
Rooting information, kickoff times, TV schedule and more for NFL Week 7.
🚨 Maroan, Iván Azón: confirmed line-ups for Athletic-Getafe
Athletic Club, unbeaten at San Mamés in the league this season, host a Getafe side in turmoil following Bordalás's inflammatory comments and a clear crisis on the pitch. Here are the lineups for to...
Browns Week 7 fantasy start-sit: Boston, Judkins, Fannin, Concepcion
Tennessee has allowed the 10th-most half-PPR points to receivers, while Dylan Sampson’s return from injured reserve threatens Quinshon Judkins’ receiving work.
Amorim eyes raid on Manchester United for £52m defender
Ruben Amorim is keen on a reunion with Manchester United defender Leny Yoro at AC Milan.The Serie A side are weighing up a move for the 20-year-old at the end of the season, according to reports in It...
2 reasons Colts can upset Vikings in Week 7 matchup
Former NFL coach Jon Gruden predicts the Colts will upset the undefeated Vikings, with ESPN analyst Seth Walder also backing Indianapolis.
Sunday Night Football: How to watch the Kansas City Chiefs vs. Seattle Seahawks game tonight
Takeaways from Colorado's disastrous 57-24 loss to Oklahoma State
Oklahoma State fell to Colorado after an abysmal second-half collapse. Here are five takeaways from the Buffaloes' fifth straight loss.
The top 25 modern golf courses in Canada, ranked
Our ranking of top modern Canadian courses returns, with Nos. 1 and 2 sitting side by side.
Unfair Links Launches a Link Building Service for Local Backlinks and Google Business Profile Matched Links
Unfair Links Launches a Link Building Service for Local Backlinks and Google Business Profile Matched Links Unfair Links Launches a Link Building Service for Local Backlinks and Google Business Profile Matched Links New York City, USA, Oct. 25, 2026 (GLOBE NEWSWIRE) -- Founded by Rollo Unden and Oliver Fish, Unfair Links builds local backlinks matched to a business's Google Business Profile, country and language, and is now taking sign-ups for its beta waitlist. Unfair Links, a new link building
CBS News political experts weigh in on Texas Senate race halfway through early voting
The latest CBS News poll showed Talarico leading 51% to 49%, well within the margin for error.
NFL.com Experts Rolling With Broncos In Week 7
Fresh off a gritty win, Denver faces an injury-riddled Arizona squad as analysts eye a potential breakout performance for Bo Nix against the struggling Cardi...
Paris Pressure: Saints Must Block Out the Chaos and Finish Their Business Against the Steelers
AP Exclusive: Trump’s border chief defends wall plans in Texas’ Big Bend despite a court setback
The Trump administration's top border official is defending plans to build a wall in Texas' Big Bend region. Customs and Border Protection Commissioner Rodney Scott argues the entire $46 billion
What Californians should know about Prop. 42
The measure could block the billionaire tax — and more.
Fantasy Football injury update: Justin Jefferson cleared for Week 7
Justin Jefferson's ankle was still on the injury report ahead of Week 7.
Green Bay Packers vs. Detroit Lions: How to watch the NFL Week 7 game, channel, streaming info and more
How to watch Lions vs. Packers: TV, streaming, radio, more
TV, online streaming, announcer, and kickoff time information for Detroit Lions vs. Green Bay Packers.
Best AI Tools for Small Business Marketing (2026): CapCut Featured for Creating Professional Video and Visual Content by Expert Consumers
Expert Consumers has recognized CapCut in its 2026 coverage of the best AI tools for small business marketing, highlighting the platform's collection of AI-powered features for creating and editing video, images, audio, and other visual content. The recognition reflects growing interest in tools that support practical marketing activities, including campaign development, promotional content production, and adapting creative assets for different digital channels.
YouTube Gold: Highlights From Louisville’s Trip To Kansas
Kansas lost Wednesday, but the Jayhawks are not exactly pushovers
As vote nears, Trump’s AI gamble fuels economic uncertainty
Some of the world’s leading financiers are sounding increasingly alarmed about an AI bubble.
Voters in 2 Democratic strongholds could ban transgender girls from girls school sports
Reliably Democratic Colorado and Washington have ballot measures that would bar transgender girls from some sports competitions
Why partisan politics may be changing people's accents
With the midterms fast approaching, communicating just the right message has been top of mind on all sides of the political aisle
Country music’s richest singer has a stunning net worth of more than $1 billion
You might be surprised to learn who has the biggest bank account.
Detroit Lions vs. Packers: Where to watch, TV channel, time
The Detroit Lions welcome in the Green Bay Packers for a pivotal Week 7 game. Here's where to watch, including TV channel and kickoff time.
Peoria businesses face dilemma at plaza owned by healthcare giant
The sale of MidTown Shopping Plaza to OSF HealthCare has left local business owners on edge. It has led to uncertainty, stalled investments and tenants bracing to start over elsewhere.