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ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Clemson HC Dabo Swinney Waving White Flag on Season
Following a humbling loss to Virginia Tech, Dabo Swinney is recalibrating expectations as the Tigers abandon playoff dreams and fight to salvage a disappointing, sub-par season.
Iowa Football Was Never Truly A CFP-Caliber Team. The Loss To Minnesota Proved It
The Hawkeyes had plenty of momentum after the Washington game, but there's just too much inconsistency right now. Everything fell apart against Minnesota.
Cutting ‘red tape’ is nothing but a red herring
Blaming a moribund economy on too many rules is a hackneyed neoliberal trope – UK plc needs smarter regulation, not less regulation
Business lessons are coming to liberal arts schools
A new AP business with personal finance course continues the growth of teaching kids about how to make money and keep it.
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race
President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day | Newsradio 1140 WRVA
What gets fact-checked? How politics shapes the answer in four African countries
Many fact-checkers are moving away from declaring claims as true or false, and trying to help people judge information for themselves.
Sullivan, Peltola seek support from Alaska Native voters ahead of crucial Senate race
The major candidates in Alaska’s U.S. Senate race are both casting themselves as strong voices on Alaska Native issues as they seek support from the key constituency ahead of the Nov. 3 election | WWJ Newsradio 950
'The church has ceded the commanding heights of science': New Trinity…
Huntsville could soon be home to a groundbreaking Christian liberal arts college focused on preparing students for careers in Science, Technology,…
'The church has ceded the commanding heights of science': New…
Huntsville could soon be home to a groundbreaking Christian liberal arts college focused on preparing students for careers in Science, Technology,…
Trump casts his midterm ballot early in Florida
President Donald Trump has cast his ballot in the midterm elections, voting for all Republicans in Florida before speaking at a Georgia rally | WWJ Newsradio 950
Los Angeles health authorities report 2nd second rabies-positive raccoon
In a follow-up on the report a rabies-positive raccoon found in Los Angeles County, the first in more than 5 decades, the LA County Department of Public Health is investigating a second rabies-positive raccoon found in the Westlake Village area of Los Angeles County. Public Health has confirmed that the first raccoon was positive for a variant of rabies typically found in bats. Strain testing for the second raccoon is currently pending. The second rabid raccoon was found in a backyard in the vicinity of where the first raccoon was reported and appeared sick and aggressive. No residents or pets were exposed to the raccoon. Two people at a worksite may have been exposed to the raccoon and are receiving recommended follow-up for rabies post-exposure prophylaxis. The World’s Deadliest Viruses Prior to these detections, the last confirmed rabid raccoon in Los Angeles County was detected in 1973, when the skunk variant (strain) of rabies was still present in the County. That strain has not been detected in Los Angeles County since 1979. In 2014, a skunk infected with the bat variant of rabies was detected in Long Beach. “The detection of rabies in another raccoon is an important reminder to never touch, handle, or feed any wild animals, even when they appear healthy,” said Muntu Davis, MD, MPH, Los Angeles County Health Officer. “Always keep a safe distance from wildlife and contact your local animal control if you encounter an animal that appears to be sick, injured, or behaving unusually. It is also critical to ensure your pets are up to date on rabies vaccination so they are protected before any potential exposure. Keeping your pets vaccinated is one of the most important steps you can take to protect your entire family.” Outbreak News Today is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe
Celebrate Halloween with Jervis Library in Rome
Jervis Public Library in Rome has announced its upcoming events for the final week in October, including being open for trick-or-treating for a book on Halloween.
What One Extra Hour of Sleep Could Do for Your Mental Health | Hartford HealthCare
Learn more about News Detail at hartfordhealthcare.org
VIDEO: Shop Local at the RI Small Business Village at Providence…
GoLocalProv.com is the “go to” local Web experience that breaks the biggest local stories – sports, news, business, weather, news, politics, arts,…
Kyrie Irving Leads Mavericks Past Pacers
Kyrie Irving delivered an impressive performance Friday night, scoring 24 points to lead the Dallas Mavericks to a 121-105 victory over the Indiana Pacers. Dallas built a commanding early advantage and held on for its first win under new head coach Dusty May, spoiling Tyrese Haliburton’s return to Indiana’s home floor. Irving was one of…
New Business: Caribbean Market reopens in Manchester; Cuban ...
Caribbean Market has reopened in Manchester after a two-year rebuild, while Plymouth’s Cuba Libre has become Viva Cuba Restaurant following a trademark issue.
The Violent Cost of Being a Woman in Politics Spans Continents
Weekend Reading on Women’s Representation is a compilation of stories about women’s representation in politics, on boards, in sports and entertainment, in judicial offices and in the private sector in the U.S. and around the world ... with a little gardening and goodwill mixed in for refreshment. This week: —There is not (yet) the political will in the U.S. to talk about gender quotas ... but 35 nations in Europe have either been mandated or volunteered to implement them. —Weeks after the brutal rape of Arizona congressional candidate Bernadette Greene-Placentia, Australian independent member of Parliament Helen Haines is in hospital in a critical condition after she was struck by a car outside her office in what Prime Minister Anthony Albanese said appears to have been "a deliberate act." —"Politicians are no longer treated like we’re human,” says Arizona state legislator Alma Hernandez, who is facing rising harassment and threats. —Federal agents searched the Washington-area home of Rep. Ilhan Omar, a frequent critic of Republican President Donald Trump. —If elected governor of Georgia, Keisha Lance Bottoms would become the first Black woman governor in U.S. history. ... and more.
How Liberterian U.S. Senate candidate Thomas Laehn said he would fight political corruption
Libertarian Thomas Laehn said that he isn't running for Iowa's U.S. Senate seat to be a "spoiler" in the race.
Trump Advisers Give Fees Earned for Aiding Srpska to His Library
The donations from James Blair and Chris LaCivita were revealed after the president expressed pique over their consulting work for Republika Srpska.
'I deliberately shrank my business for better work-life balance'
Emma Hine swapped her corporate job for running her own company to get a better work-life balance.
Business News: LVMH-Owned Zenith Is Restructuring In Major Reset As Brand Plans Job Cuts And Production Drop In Shift To High-End Market
Up to half of the employees at Le Locle manufacture could lose their jobs as the brand cuts models and production in restructuring after years of financial losses.
Why ultra-Orthodox parties hold so much sway in Israeli politics
Ultra-Orthodox Jews, often called Haredim, make up a small but growing percentage of Israel’s population. Still, their political parties wield significant influence.
What's happening at the Waunakee Public Library
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Pope hope, that’s entertainment, and getting ahead in the CIA
Happy Friday friends, I want to start by just breathing for all of us a big long collective sigh of relief at the news this week that the pope’s doctors have basically blown the all clear for Leo’s health. Going from knowing nothing to him declaring to the world he needed surgery, to a cancer diagnosis, to bouncing out of the hospital in barely even days, to ringing the bell in less than two weeks is whiplash inducing. But in the best possible way. We are living in a world in which the Roman pontiff, by dint of history, biography and circumstance, is once more at the epicenter of global affairs. Not just conversations about religion, or Christian and post-Christian values, but the bleeding edge of the most pressing issues of human affairs. Think I am exaggerating a touch? Consider the images of the crowds who greeted Leo in Paris just weeks ago, and juxtapose them with the absolute photo negative scenes unfolding there recently. Ask yourself how many world leaders are talking about AI right now and directly citing the pope as they do so. Try to name a country who has had as many top-ranked diplomats in and out of both Russia and Ukraine in the last three years as the Vatican has in the last three months. It has been fascinating to watch Leo XIV emerge as not just a kind of pop culture reference point or totem to be cited (Francis was often name-checked this way) but as a kinetic force in global conversation. Given the state of things, we need global figures of gravitas and values, even better if they have real wisdom behind what they are saying. So news of Leo’s illness was, it seemed to me, a tremor with potentially Richter Scale implications. That not only has the worst not come to pass but instead we’ve had the best of outcomes announced is something to really be grateful for. Humanity, it seems to me, is entering one of its irregular but cyclical phases where the pace of change — technological, social, and geopolitical — outstrips the ability of previously settled norms and received wisdom to cope. Such periods – and I think the first decades of the last century were a similar such time – throw into question the viability of all kinds of institutions. And many of ours have been straining to breaking point for a few years now. The papacy has the power and the potential to be a steadying pole in all of this. That’s my hope, anyway. It’s a lot to freight the office with, though it is arguably its ultimate purpose from its founding, to be a steadying rock on which all that matters can be anchored. It’s also, of course, an intolerable weight of responsibility to place on a single man. But I am encouraged to have hope in – and for – Leo. The apostle whom he succeeds, after all, was famously unequal to some moments, failed some tests of faith, and resiled from taking the road which led ultimately to the circus on Vatican hill. Human frailty and limitations, of health, of character, of temper, can open us to Christ, whose strength is greatest in our weakness, so St. Paul learned. That gives me hope, and I am sure it consoles Leo, too. And so I will continue to pray for him. Because we need apostles of rock right now. Here’s the news. Subscribe The News The Dicastery for the Doctrine of the Faith issued yesterday a new document “Venite ad me: Considerations on the Transmission of the Faith in an Epochal Change.” It’s not a short document, and it is at pains to stress this isn’t a doctrinal note from the dicastery, either. Rather, it brings together reflections on an important issue from the Church around the world. Some of it I actually found really rather powerful. It is, however, 25,000, which is a lot for a busy reader to get through on a weekday. So, you can read our busy reader’s summary right here. — News broke yesterday of an Oct. 22 meeting of U.S. bishops with President Donald Trump. The meeting was organized by an official at the Heritage Foundation, according to several sources close to the meeting. Video of several U.S. bishops praying in the Oval Office over President Trump was posted on social media Thursday afternoon, first by White House Communications Advisor Margo Martin, and then by the official twitter.com account of the Archdiocese of Denver. The meeting has drawn sharp criticism because of its proximity to the upcoming midterm Congressional elections, in which Democrats are widely expected to win control of the House of Representatives, while control of the Senate remains closely contested. Sources close to the bishops’ conference told The Pillar that some USCCB senior officials were surprised by the existence of the meeting when video of it first emerged online. And a source close to conference president Archbishop Paul Coakley of Oklahoma City told The Pillar that the archbishop was “deeply frustrated” by the occasion of the meeting. An official conference spokesperson told The Pillar that the meeting was “not organized with or by the USCCB” and was “not affiliated with the conference.” You can read the whole story here. — The next National Eucharistic Congress will be held in Indianapolis in 2029, a return to the city that hosted the last gathering in 2024. You read it here first. By here, I don’t mean this newsletter, I mean at The Pillar. We broke the story this week. It’s a big deal, in as much as the last congress was a roaring success and the next installment has the potential to be a real focal point for evangelizing efforts in the coming years. Read all about it here. — As Pope Leo prepares for the longest trip of his pontificate, Church leaders in Uruguay say the pontiff will encounter a highly secularized culture, in a country with a very different Catholic history than many of its South American neighbors. The nation has not had a papal visit since 1988, and leaders who spoke with The Pillar say it has a dire need for evangelization, even amid the prospect of a small revival in faith. This is real reporting on the Church in the country, and frankly a story you simply are not going to be able to read anywhere else. Read the whole thing. — The Archdiocese of Detroit announced this week a plan that would see the vast majority of its parish priests reassigned next summer, amid a restructuring process expected to dramatically shrink the number of parishes in the archdiocese. Archbishop Edward Weisenburger said this week that the plan “asks much of our priests,” but is a “sacrifice they are making as brothers of one, unified presbyterate.” The thing is, as JD pointed out in an analysis yesterday, pastors of parishes have a legal right to stability in office, so the only way this kind of wholesale reassignment goes ahead is if all of the archdiocesan clergy agree to resign. That creates its own kind of legal issues, though, and re-raises longstanding questions about the effectiveness of canonical due process protections for priests when dealing with coercive exercises in authority. Read the whole thing here. — More than three months after the Dicastery for the Doctrine of the Faith issued its decree declaring the excommunication of the leadership of the Society of St. Pius X, questions remain about the full effects of the society’s schism. Specifically, the DDF’s July claim that marriages witnessed and confessions heard by SSPX priests are now invalid remains contested — and it emerged this week it appears that the Vatican’s own legal experts don’t agree. You can read my whole analysis of the situation and what it means here. All I would add is that the DDF’s undeveloped, some would say unsubstantiated, claim about the invalidity of some SSPX sacraments came in their July Explanatory Note on the schismatic consecrations by the society that month. It touches directly on both papal acts of governance — indeed it purports to nullify them — and the most intimate pastoral encounters possible in a parish setting. If there is one aspect of the Francis-era style of governance I would like the curia to finally cut out, root and branch, it would be these attempts to try to effect extraordinarily sensitive legislative acts via a note. — At least a dozen French bishops have spoken out following an eruption of violence on the country’s streets Oct. 17. Not surprisingly, they unanimously condemned the violence, but the length and content of their interventions varied significantly. Several sought to distinguish between the actions of rioters and what they suggested were the legitimate concerns of peaceful young protesters. Many also evoked Pope Leo XIV’s Sept. 25-28 visit to France, suggesting it offered a powerful counter-image to the scenes of looting and destruction. A number of bishops also stressed their solidarity with law enforcement officials who struggled to contain the disorder, as well as the owners of the roughly 3,000 damaged or looted businesses. What’s the background to the nationwide unrest that the French media calls “les violences du 17 octobre”? And what exactly are the bishops saying? Read all about it here. — A Polish bishop called for the firm defense of unborn children as well as compassion for their mothers this week, as the lower house of Poland’s parliament passed two bills seeking to liberalize the country’s abortion laws. The bill on decriminalizing assistance in an abortion passed by 217 votes to 213, while the abortion in cases of fetal abnormality bill passed by 233 to 203, thanks to the government’s majority in the lower house. Both bills will now move to the Polish Senate, the upper house of parliament, where the ruling coalition has a larger majority. The fetal abnormality bill is symbolically significant because if it became law, it would effectively overturn a 2020 ruling by Poland’s Constitutional Tribunal that a 1993 law permitting abortion for a severe and irreversible disability or a life-threatening incurable disease was unconstitutional. Read the whole story here. Subscribe **[The St. Paul Center App | Bible Study On-The-Go Read and understand the Bible with St. Paul Center’s new app! With today’s leading Catholic Scripture scholars as your guides, the St. Paul Center app empowers you to read the Bible](https://stpaulcenter.com/app?utm_source=pillar&utm_medium=email&utm_campaign=applaunch)** from the heart of the Church. Download the app for free at either the Apple or the Google app stores. https://stpaulcenter.com/app That’s entertainment I have written before about my deep and sincere reservations about the celebrity exorcist subculture which has taken root in American Catholicism. And, because I am very ill at ease with the entire thing, I try to keep a weather eye on the phenomenon without being drawn into the kind of online back-and-forth which these figures sometimes generate. Earlier this week, JD noted that one such celebrity exorcist type, Fr. Chad Ripperger, has undertaken, on the request of his bishop, a year’s fast from interviews and public speaking. I’m sure that will be salutary for him, if for no other reason than that receiving with docility requests from one’s rightful ecclesiastical superiors always comes with graces. Then a second thing happened this week which caught my eye. Apparently, another fixture in the celebrity exorcist world, Fr. Carlos Martins, has initiated a lawsuit against two lay men — apparently associates of Rippenger, though I am unclear in what way, exactly — for allegedly defaming him and his ministry on a podcast. It seems the suit was initiated nearly a year ago and is now pending. At issue, I read, is that the two men described Martins on a podcast as “not who he says he is” with regard to his exorcism ministry and that he “doesn’t know what he’s talking about.” These statements Martins considers to be false and defamatory and, his suit claims, “directly affected the sale and reception of [his] The Exorcist Files book that was newly released at the time these episodes aired.” I don’t want to get too into the weeds of the details here, but a couple of things struck me about all this.
Why Is James Talarico’s Final Message to Voters ‘Friday Night Lights’–Themed?
The Democratic candidate for U.S. Senate leaves it all on the field.
Does technology liberate you or enslave you?
When you can organize and manage things properly, it’s amazing how much you can accomplish without living at work
Nintendo Expands Switch Online's Game Boy Library With Three More Titles
Avenging Spirit, Mole Mania & Revenge of the 'Gator are back
Health Organizations Release Revised Physician Practice Framework
The Royal College of Physicians and Surgeons of Canada’s revised framework for physician education and practice emphasizes health equity and technology.
RI Small Businesses vs. Costco, Foulkes and Raimondo
GoLocalProv.com is the “go to” local Web experience that breaks the biggest local stories – sports, news, business, weather, news, politics, arts,…
Trump and crypto firm sued for profiting from foreign government
Donald Trump and World Liberty Financial, the cryptocurrency venture he co-founded with his sons, were sued by a shareholder in a rival crypto firm over claims the president illegally profited
All My Hobbies Are Getting Slopped Up, And It’s Exhausting
The explosion in vibe coding has created an endless sea of drive-by, unserious, and unmaintained software that is attacking the communities around them.
Lawsuit accuses Trump of illegally profiting from UAE crypto investments
The lawsuit claims the investments violate the Constitution’s foreign emoluments clause
Lawsuit accuses Trump of illegally profiting from UAE crypto investments
The lawsuit claims the investments violate the Constitution’s foreign emoluments clause
Libertarianism Is Equality of Permission
“Without shared standards of right and wrong, it’s impossible to settle disputes; it’s impossible to maintain social cohesion and trust. Every healthy society rests on some shared conception of the sacred.”
Vikings Receive Wild Speculation on Trade Deadline Moves
With Minnesota sitting undefeated, analysts suggest a blockbuster trade for a Pro Bowl quarterback could turn their championship-caliber defense into a definitive Super Bowl favorite.
Trump’s shock-jock politics don’t work for everyone. An Ohio attack ad is proof.
Cheered by an online ecosystem, the GOP has rewarded “owning the libs” for a decade. But the blowback to an ad in the governor’s race suggests there are limits.
Inflation at the movies: Runtimes are longer, from 'The Odyssey' to 'You Can See Everything'
Your bladder isn’t lying | Talk 1370
Report: Arizona men’s basketball roster spending trails top programs
Arizona men’s basketball’s budget for building a Final Four-caliber team is significant, but the UA is far from one of the top spenders in the sport, according to a new report on roster spending. Arizona will spend approximately $15-17.5 million on its men’s basketball roster, CBS Sports’ Matt Norlander and Isaac Trotter reported this week. […]
Huntington startup creates landmark-inspired pajamas and gifts
Huntington-based Oyster and Arrow creates hand-illustrated pajamas and gifts inspired by Long Island landmarks. Founded by Emily Greany, the company emphasizes local coastal motifs and has grown to 25 retail partners, with wholesale driving most of its revenue. The brand aims to expand along the East Coast while maintaining personal connections.
Love Is Blind’s Sarah addresses conflicts with John over anger issues, politics
‘Love Is Blind’ season 11 star Sarah spoke to EW about John’s reaction to his phone bill, and how their politics could affect their relationship.
John Anderson, country music star whose hits included 'Wild and Blue,' dies at 71
Country Music Hall of Famer John Anderson has died at age 71 | WBBM Newsradio 780 AM & 105.9 FM
Women who changed science missing from GCSE and A-level courses
Despite social, economic and institutional barriers limiting women’s formal participation in science, they made numerous key breakthroughs.
NBA season-opening takeaways: Giannis, Lakers, Ant-Melo, Damian Lillard, Tyrese Haliburton and first impressions
Accounting firms grow advisory services for growing clients
New York accounting firms like Geller & Company and Grassi Advisors expand advisory services to meet growing client demands for strategic financial guidance.
John Legend on Pharrell’s musical push, Jay-Z’s praise and new creative challenges with ‘Muse’
Jay-Z once called John Legend “our voice,” but Pharrell Williams had a different idea for Legend's baritone | WWL
Australian treasurer says opponents want higher inflation for political gain
In a Canberra Playbook Podcast interview Jim Chalmers accused Liberals of wanting Australians to suffer, as their path back to power.
Introspection required if EU Inc fails, says start-up lobbyist
European start-ups have a new voice in Brussels. Startups for Europe, created from the merger of lobby groups Allied for Startups and the European Startup Network, is hoping to harness the momentum behind EU-Inc, a campaign that united start-ups and investors behind demands for a new pan-European company regime.At a launch event for the new association in Brussels on October 1, the mood was remarkably upbeat compared to a typical Eurobubble gathering, more Silicon Valley than Schuman roundabout.When asked whether this reflects a feeling that Europe is on the right track, chief executive Serena Borbotti-Frison said it’s a “scary” moment as the continent looks to boost its competitiveness amid a new technological arms race.“What is at stake is quite intense, and the way we can answer is by delivering, but also with hope,” she told Science|Business. “It’s what our industry does. It’s not about identifying a pain point and then saying it’s too hard.”For many in the start-up community, that sense of hope is dwindling. In March, the European Commission presented its proposal for EU Inc, naming its initiative after the grassroots campaign.EU Inc was meant to be a gamechanger: the ability to incorporate within 48 hours for less than €100 and scale up across Europe; a harmonised stock option regime enabling start-ups to compete for talent; and simplified insolvency procedures for innovative start-ups to reduce the cost of failure.However, haggling by EU governments has raised concerns that EU Inc will be stripped of the very features, including stock option harmonisation, that are meant to make it attractive for companies.“I fear we are proving to ourselves that the model doesn’t work,” Borbotti-Frison said of the policymaking process. “Everyone agrees we should have EU Inc. Everyone agrees it’s hard to scale and we need to scale to answer the competitiveness [challenge], and still we cannot deliver? [. . .] What does that say about ourselves?”The Commission has made EU Inc a cornerstone of its single market reform, and has agreed with the European Parliament and the Council of the EU to target an agreement by the end of 2026. However, several points are currently holding up an agreement, including national rules around employee participation in management decisions, and the provision that employee stock options always be taxed at the point of sale. Some EU governments have reportedly pushed back on the Commission’s choice of legal basis, contending that anything related to taxation requires unanimity in the Council.Trade unions have also protested against EU Inc, fearing it will be exploited by companies looking to undermine workers’ rights.“If this doesn’t work, it’s introspection time, on the way our institutions work, maybe the way our lobbies work, and maybe the way the cooperation between them works,” Borbotti-Frison said.“Is it in the national interest? Is it a gap between political will and technical ability to operate? Is it speed? I don't know, but something needs to be fixed.”Ahead of last week’s European Council meeting, EU-Inc campaigners tried a new strategy: appealing directly to EU presidents and prime ministers. In an open letter, they urged EU leaders to “step in and give your negotiating teams a clear mandate to change course and reverse their objections to the Commission’s original proposal.”Lessons from EU-IncLike its predecessors, Startups for Europe will represent national start-up associations, but it is also targeting investors. The founding sponsors are venture capital firm Atomico and EQT, the investor selected earlier this year to manage the €5 billion Scaleup Europe Fund.It also wants to harness the knowledge and cross-border experience of European success stories. “Take the list of the 100 biggest unicorns in Europe. We are speaking to all of them,” Borbotti-Frison said. The association plans to publish a full list of supporters following the Slush tech conference in Helsinki in November.Andreas Klinger and Simon Schaefer, two key figures in the EU-Inc campaign, are both on the board of the new association, and Startups for Europe wants to take the lessons from their campaign.What was unprecedented about EU-Inc was “how rooted it was, and how strong it was in bringing everyone on board behind one clear pain point and solution to fix it,” Borbotti-Frison said. “This is an inspiration for us, and then we need to turn it into something more systematic, more bridged in Brussels, more connected to the policymaking game, and to scale it.”If it’s possible to unite such a broad coalition, it’s because the European start-up ecosystem is now mature, she said. “Maybe it was not ten years ago. Maybe it was not five years ago. But now, it’s mature to speak with one voice.”Open and liberal EuropeThe association plans to campaign on files related to three “pain points,” Borbotti-Frison said: “start and scale in Europe, fundraise and invest in Europe, and making Europe the most innovative continent.”As well as EU Inc, she cited public procurement, the EU’s simplification push, the Savings and Investments Union, and files related to AI adoption and technological sovereignty as priorities for the coming months.What these files have in common is that they relate not to subsidies but to the framework conditions influencing the availability of mostly private, or in the case of procurement, public, funding.Related articlesEmployee participation disagreement delays MEPs’ vote on EU IncCommission urges EU governments not to water down EU IncEU’s ‘ultra-fast’ €5B scale-up fund is set up to win, says its fund managerThe budget dispute over the next Horizon Europe programme will also impact start-ups, which are supported notably through the European Innovation Council. But EU innovation funding is a drop in the ocean compared to venture capital and public procurement budgets.“If competitiveness and innovation are a priority, then the [EU budget] should reflect it,” Borbotti-Frison said. However, she added that the main question is not how much public money is invested, but “how do we create the right conditions for the market to solve the problem?”The Scaleup Europe Fund mixes both approaches, using €1 billion in EU funding to crowd in private investors and address Europe’s lack of large-scale, late-stage growth funds. “It’s a proof of concept. Ideally, then the market will do it itself,” Borbotti-Frison said.Startups for Europe is also focused on bringing an alternative political narrative. Amid competing visions for open, global markets on the one side and a protectionist Europe on the other, it wants to offer “a third voice, to say we can be proudly European and build a strong continent in a liberal economy, open to the world, and global.”It can be tempting, when thinking about how Europe can better support innovation, to look across the Atlantic. But while it’s important to compare statistics to see where Europe needs to catch up, that’s where the comparison should stop, Borbotti-Frison said. “On everything else, we need to do it our own way. We don't have the same history. We don't have the same political model. We don't have the same way of life.”Many of the key files that could benefit the start-up community, including EU Inc and the Savings and Investments Union, rely on closer integration within Europe, making it easier to operate across borders.While the Commission has made deepening the single market a political priority, support at national level is more precarious. The coming months will see pivotal elections in Spain and France, while the German government has also been coming under pressure domestically. In each country, far-right parties have been gaining ground.When asked if she was concerned the political situation could jeopardise this progress, Borbotti-Frison responded: “Of course. I would be lying if I said I wasn’t.” However, she continues to believe that cooperation is the only way forward. “Doing it alone is not the solution. It’s also not who we are, it’s not the model we are building, and it’s not the scale we need.”
How to watch Navarrete vs Foster and Smith vs Puello: Combat sports on DAZN this weekend
Find out how to watch Navarrete vs Foster, Dalton Smith vs Alberto Puello, RWS Muay Thai and Hitman Fight League on DAZN this weekend with fight dates, cards and viewing details.
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Tom Cruise is being honored with a life achievement award from the American Film Institute | WBBM Newsradio 780 AM & 105.9 FM
Tom Cruise to receive life achievement award from the American Film Institute
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ChristianaCare opens Health Center, completing next phase of Aston campus
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Political science, history student connects hometown roots to DC policy work
Dawson Glogau gained hands-on experience in policy research and advocacy during a summer internship in Washington, D.C., through the Liberal Arts Semester in Washington Program.
NYC Health + Hospitals/Elmhurst and Queens Public Library Expand Partnership to Bring Health Education and Library Resources to Queens Residents
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Tawas City Library Friends celebrating 20 years
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A new Beatles attraction is coming to Liverpool as interest in the Fab Four surges
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Mandy Moore, Emmy Rossum among A-list speakers at WME's inaugural Women’s Health Summit in Malibu
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Nine State Board of Education seats are on the ballot this fall, including 4 in the Greater Houston Area
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Are transgender sports bans really about protecting women? Survey data tells a different story
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Miniso Land retail and entertainment concept coming to UK
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Pfizer makes ‘business decision’ to end phase 2 trial of autoimmune drug as program’s future uncertain
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After years of backlash, Apu returns to 'The Simpsons' with a South Asian voice
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Bills OL Bonded Over Fish Tacos During West Coast Trip
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Ohio University Chemistry Professor Eric Masson develops open-source software to advance chemical research
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Essentia Health hosting Hypertension Night
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Helen Haines: Australian MP critically injured after apparent car attack
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