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Cracking a smile can boost health–experts
And rather than wait for a reason to smile, just making the physical change of literally turning that frown upside down could impact emotions
Primark's Business Doesn't Make Sense
In a world where fast fashion giants like Shein, Zara, and H&M drop thousands of new styles every day — and rake in billions through e-commerce — Primark is doing the unthinkable: thriving with zero online shopping. So what gives?*Want to Know the 5 Trends Changing Modern Retail? Find Out Here:* 🔗 https://clickhubspot.com/d13ac2In this video, we take you inside Primark’s weirdly brilliant business model — a model that’s stuck in the past on purpose. From warehouse optimization and floor-ready freight shipments to why the pandemic didn’t push them online, we unpack how this low-cost retail giant has managed to defy digital norms… and make it work.This isn’t just about one brand. It’s a story about modern retail expectations — and what it actually takes to meet (or reject) them.Subscribe to The Hustle:🔗 https://clickhubspot.com/vu3lGet the 5-minute newsletter keeping 2M+ innovators in the loop🔗 https://clickhubspot.com/3klnAbout HubSpot: HubSpot is a customer platform that provides education, software, and support to help businesses grow better. The platform includes marketing, sales, service, commerce, operations, and website management products that start free and scale to meet our customers’ needs at any stage of growth. Today, thousands of customers around the world use HubSpot’s powerful and easy-to-use tools and apps to attract, engage, and delight customers.#TheHustle #HubSpot
Rep. Carbajal Meets with Cottage Health’s Head Honchos in Santa Barbara as They Brace for ‘Big Beautiful Bill’ Impacts
Trump’s bill expected to leave close to 40,000 Central Coast residents without health coverage, another 37,000 with higher premiums, and a roughly $40 million initial impact on Cottage.
‘Masterplan’: Too lightweight to make an impact
Pretty faces can’t overcome ho-hum plotting
What To Make Of The Washington Nationals Catching Unit
Analyzing the 5 Nats catchers most likely to make a big league impact in 2027
Retire Your Old Fountain: The Alternative From Home Depot Perfect For Your Small Patio
The Teamson Solar Gray Stone Wall Fountain from Home Depot is a great fountain for small patios thanks to its compact size and solar powered design.
Cattle Science Gets a $19.5 Million Upgrade as West Texas A and M Plans High-Tech Research Complex
West Texas A&M is building a $19.5M cattle research complex featuring AI technology, veterinary research and commercial-scale feedlot studies.
Game Time Thread: Juventus vs. Lecce
MATCH INFO When: Sunday, Oct. 25, 2026. Where: Stadio Via del Mare, Lecce, Italy. Official kickoff time: 6 p.m. local time in Italy and across Europe, 8 p.m. in the United Kingdom, 1 p.m. Eastern time, 12 p.m. Central time, 10 a.m. Pacific time. (Please note that the fall time change in Italy goes into effect on Sunday, […]
Packers Lose Defensive Captain Just Before Massive Showdown With Lions
Green Bay Packers defensive captain Zaire Franklin has been ruled out against the Detroit Lions, leaving Green Bay without both starting linebackers.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Opinion - How Trump learned to stop worrying and love space science
He recognizes a cool thing when he sees it.
NFL Week 7 expert picks, score predictions: Packers at Lions
Green Bay Packers vs. Detroit Lions NFL Week 7 expert picks from the Pride of Detroit staff.
Clay Walker Christmas coming to NPAC Nov. 29
GREENEVILLE — Rumor has it … it’s shaping up to be A Clay Walker Family Christmas.
Local breakfast chain plans Derby expansion
The Easy Egg, a Wichita-based breakfast and lunch restaurant, recently announced plans to expand into Derby. Reports indicate the local chain will take over the space at 317 N. Rock
Detroit Lions updated depth chart: Week 7 vs. Packers
An updated look at the 2026 Detroit Lions’ depth chart ahead of their Week 7 game vs. the Green Bay Packers.
Updated SEC football conference standings following Week 8 upsets
The SEC's Week 8 slate produced a number of notable results. Here is how those results impacted the conference standings entering Week 9.
Green Bay Packers vs. Detroit Lions: How to watch the NFL Week 7 game, channel, streaming info and more
How to watch Lions vs. Packers: TV, streaming, radio, more
TV, online streaming, announcer, and kickoff time information for Detroit Lions vs. Green Bay Packers.
Cosmic 'seagull' locks eyes with the Vera C. Rubin Observatory in long-awaited test image — Space photo of the week
Stare into the transfixing eye of the "Seagull Nebula" in this newly-released test image from the visionary Vera C. Rubin Observatory.
Detroit Lions vs. Packers: Where to watch, TV channel, time
The Detroit Lions welcome in the Green Bay Packers for a pivotal Week 7 game. Here's where to watch, including TV channel and kickoff time.
Democrats Bob Brooks, Paige Cognetti lead GOP incumbents in pair of key Pa. swing seats
Republicans are on pace to lose the two U.S. House seats they flipped just two years ago, according to a new Inquirer/New York Times/Siena University poll.
Bust companies revived in ‘phoenix’ deals more likely to fail again, study finds
Exclusive: Research for the Guardian says ‘pre-pack’ administration deals pay far less to creditors
Inside a California shopping center's struggle to reinvent mall food
LOS ANGELES — Westfield Topanga is one of Southern California's most popular malls, but it has grappled with what to do with the empty space left when it lost its
Cougars picture-perfect Homecoming scene goes sideways
When the meeting between Washington State and Boise State was announced, it was immediately circled by many to be one of the better games of the revamped Pac-12 slate. Especially in the timeslot it was put in. A late October matchup at 3pm in Pullman. College football is arguably at its peak around this time […]
Kansas City leaders, non-profits and businesses turn unity into investments
Neighborhood leaders, nonprofits and businesses packed into Kansas City, Kansas, on Saturday, focused on turning unity into real investments.
READERS' CHOICE | Impact Realty Group makes its mark with Best Small Business win
A locally owned and operated real estate brokerage has been named Best Small Business in the 2026 Texarkana Gazette Readers' Choice Awards.
Lions vs. Packers: 3 Best Player Prop Bets for Sunday's Showdown
The Lions and Packers bring explosive offenses into Sunday's divisional showdown. I'm 10–8 on the season and targeting three player props to cash at Ford Field.
FEMA deadline approaching for NW Indiana residents, businesses impacted by Aug. 11 storms
Addressing mental health and loneliness through art: LaunchSpace's SocialRx program gets United Way funding support
LaunchSpace's SocialRx program received a $75,000 grant from the United Way of Franklin & Hampshire Region to boost regional wellness.
Scientists Studied 865 Humpback Whales and Found They Grow Faster Than Expected
Despite decades of environmental change and population recovery, eastern Australian humpback whales appear to have maintained their historical adult size. Eastern Australian humpback whales grow at an extraordinary pace, reaching approximately 10.9 meters (35.8 feet) in length by age five. By six or seven years old, they have already attained about 90 percent of their
How to watch every ‘Rambo’ movie in order, from ‘First Blood’ to ‘Last Blood’
The ‘Rambo’ franchise spans five movies and more than 40 years, with a prequel on the way in 2027. Revisit Sylvester Stallone’s action-packed saga, from ‘First Blood’ to ‘Last Blood.’
OPED-YOUTH-MENTAL-HEALTH-COMMENTARY-FILEPIC-DMT
In their daily lives, young people are navigating ever-evolving digital spaces that have not been designed with their needs at the forefront.
Packers Star Reveals Turning Point After Brutal Start to Season
Green Bay Packers safety Evan Williams pointed to the team’s Week 3 loss to the Atlanta Falcons as the moment the defense raised its standards after an uneven start.The Packers entered that Thursday Night Football game at 1-1. They had dropped their opener to the Minnesota Vikings before beating the New York Jets in overtime. […] The post Packers Star Reveals Turning Point After Brutal Start to Season appeared first on HEAVY.
Detroit Lions Announce Decision on Brian Branch, Cade Mays
The Detroit Lions officially activated Brian Branch and Cade Mays ahead of Sunday's Week 7 showdown against the Green Bay Packers.
Packers activate Josh Jacobs
Packers running back Josh Jacobs is set to make his first appearance of the 2026 season.
Sportsbooks, Prediction Markets Set Records for Political Spending
Sportsbooks routed more than $80 million through a super PAC as the AGA and Kalshi stepped up lobbying in a fight over prediction markets.
IDF, Defense Ministry struggle with amount of reservists seeking mental health care, experts say
The IDF Spokesperson's Unit said the military places the utmost importance on providing mental health care and has expanded the capacity and quality of its services since the war's beginning.
1 player Packers must trade before 2026 NFL trade deadline
The Green Bay Packers have become an intriguing team to watch ahead of the November 10 trade deadline, with speculation linking them to Arizona Cardinals pass rusher Josh Sweat . This potential move has an unusual connection to the Micah Parsons trade, as Dallas is also being mentioned as a possible destination for Sweat while Green Bay awaits […] The post 1 player Packers must trade before 2026 NFL trade deadline appeared first on ClutchPoints.
Who’s coming back for ‘Shrinking’ season 4? What’s next for the Apple TV dramedy
The hit Apple TV dramedy ‘Shrinking’ is moving forward, just like its characters. We unpack everything we know so far about season 4, including who’s returning.
Pittsburgh Pirates Elite Prospect Has Clear Goal for 2027
Murf Gray wants to impact the Pittsburgh Pirates roster at some point next season.
AOC can draw a crowd. The midterms will test whether her politics can win before 2028
Alexandria Ocasio-Cortez is drawing big crowds as she campaigns for progressive Democrats before the Nov. 3 election. Supporters have packed rooms and chanted her name during appearances that have taken
“Wicker” stars have a theory on why women are ‘slightly feral’ over Alexander Skarsgård’s character
Skarsgård’s sexy basket is “the whole package,” costar Olivia Colman says.
To survive Detroit shootout, Packers should look to Thanksgiving win
The Packers are likely to face a high-scoring matchup on Sunday. Here are three ways they can survive.
Cracking a Smile Regularly May Be Good Not Just for Your Mood but for Your Health
Reminding yourself to smile often can not only make more friendships but it can also make you feel better. And rather than wait for a reason to smile, just making the physical change of literally turning that frown upside down could impact emotions, according to experts. Research backs up the fact ...
Renew or relocate? A business owner’s big quandary
The temptation in these situations is to begin by asking, “What space is available?”
Next stop: Detroit
The Packers departed Green Bay's Austin Straubel International Airport on Saturday, Oct. 24, 2026, for their Week 7 matchup against the Detroit Lions.
Nvidia's RTX Spark has an NPU it barely mentions, and I spent a week figuring out what it actually is
Nvidia's RTX Spark packs an NPU that we know very little about, but I was able to get it working.
Preview: Bruins look to stay on pace against Sharks
Just the facts Know your enemy Game notes The Sharks come to Boston on a two-game wining streak. They picked up a win Thursday night, beating the Ottawa Senators 6-2. Tonight’s game ends a six-game road trip for the Sharks where they are 3-1-1. It’s a fairly quick turnaround as the Bruins and Sharks will […]
Packers Draft: College Football Discussion, Week 8
Mississippi-Texas is the premier SEC matchup of the week
University of Scranton awarded nearly $5.5 million NASA grant for space science education
FOX56 WOLF TV carries news, sports, weather and coverage of local events in the Wilkes-Barre, Pennsylvania area, including Mountain Top, Plymouth, Nanticoke, Kingston, Back Mountain, Scranton, Moosic, Pittston, Avoca, Edwardsville, Hilldale, Wyoming, Laflin, Yatesville, Pittston, Dupont, Sugar Notch, Korn Krest, Warrior Run and Larksville.
This decade has been missing its big-impact midterm
Every other decade over the past hundred years has produced at least one midterm that made a big difference in Congress and in national politics more broadly.
Forget Mars, SpaceX’s Most Important Business Has Nothing To Do With Space (At Least For Now)
SpaceX just reported its biggest quarter ever, and the segment driving most of that growth has nothing to do with rockets, satellites, or Mars. One business unit is now pulling in more revenue than Starlink, and it may reshape what SpaceX actually is.
Leclerc tops both Austin practices but warns Verstappen and Antonelli have more in hand
Charles Leclerc was fastest in both Friday practice sessions at the United States Grand Prix, but he does not think he goes into qualifying as the favourite. The Ferrari driver believes Max Verstappen and Kimi Antonelli have more pace to come, and he says his team's Austin upgrade is smaller than people expected.
Can millions of people live on the moon? These scientists say yes — but not for very long
Billionaires like Elon Musk and Jeff Bezos are claiming that we can expect big cities with millions of people on the moon, but a new study found that that may not be possible, so don’t start packing just yet.
Kyrie Irving Leads Mavericks Past Pacers
Kyrie Irving delivered an impressive performance Friday night, scoring 24 points to lead the Dallas Mavericks to a 121-105 victory over the Indiana Pacers. Dallas built a commanding early advantage and held on for its first win under new head coach Dusty May, spoiling Tyrese Haliburton’s return to Indiana’s home floor. Irving was one of…
Join Overtime to talk south Georgia ball with WALB Sports
With an action-packed week in SGA high school football, there is still so much to talk about in Locker Room Report Overtime.
Political expert breaks down potential impact of Obama, Trump visiting Michigan
Xbox announces 7 new games coming to Game Pass
The ID@Xbox and IGN Showcase was packed with gameplay reveals, new trailers, and more. On top of that, several new titles were also announced for Game Pass members.
Pacers’ Defense Struggles in Blowout Loss to Mavericks
The Indiana Pacers' defense couldn't get enough stops in their loss to the Dallas Mavericks.
Fans surpass American Family Field capacity for World Series opener
There were more fans in attendance at American Family Field than the stadium has seats for Game 1 of the World Series.
Fever owner Pacers Sports & Entertainment release statement after firing Amber Cox
The Indiana Fever have parted ways with general manager Amber Cox after their season ended early in the postseason at the hands of the Las Vegas Aces. Pacers Sports & Entertainment confirmed in a statement on Friday that Cox will follow team president Kelly Krauskopf , who announced earlier that she was stepping down from her role. Mel Raines, […] The post Fever owner Pacers Sports & Entertainment release statement after firing Amber Cox appeared first on ClutchPoints.
Seven-region study ranks Northwest Arkansas at top in jobs and business growth, at bottom in average wages
Northwest Arkansas outpaced six peer metropolitan areas in job growth, business establishment growth and high-tech employment growth in 2025, according to the 2026 state of the Northwest Arkansas region report release Friday.
Omaha Tribe opens $8.5M water treatment plant, quadrupling capacity
The Omaha Tribe of Nebraska has opened the Umóⁿhoⁿ Ní Waxúbe — Omaha Sacred Water Treatment Facility, Ní Ti, an $8.5 million plant that quadruples water storage capacity, according to utility director Jerry Henscheid. The facility came online Oct. 6 on the Omaha Reservation in northeastern Nebraska, replacing a plant built in 1980 that had […]
NASA Is Still Aiming for the Next Moon Landing in 2028
Administrator Jared Isaacman said that the space agency was exploring ways to keep Artemis III on target without compromising safety.
The latest in space science: We look back at the Big Bang
In this edition of Spacing Out, the team from Short Wave shares the latest developments in space science, including the theory on why the universe is made of matter
Political science professor speaks on impact of Harris-Colom rally
A professor said high-profile supporters may motivate voters ahead of midterms.
NASA’s Swift Mission Ends Ahead of Re-Entry
NASA’s Swift has concluded operations, leaving behind a legacy of innovation and a treasure trove of science observations.
CalViva Health invests $250,000 in Fresno Pacific University nursing lab
Discover how CalViva Health supports Central Valley communities through a $250,000 nursing lab investment, scholarships and partnerships. Read more today.
NASA’s Swift Mission Ends, Leaves Behind Scientific Bonanza
NASA’s Neil Gehrels Swift Observatory has ended its science mission now that the spacecraft is orbiting less than 171 miles (275 kilometers) above Earth’s
Alamo Coffee closes in Round Rock
The Round Rock location of Alamo Coffee closed in October after more than four years of operation.
Cook Political moves Ohio governor’s race after Ramaswamy attack ad
The race moved from “toss-up” to “Lean D.”
Does Rosemary Oil Really Help Hair Grow? Here’s What the Science Says
TikTok swears by it for thicker, fuller hair. But can this viral beauty hack actually deliver results?
Jordan Love set to play in Week 7
Packers QB Jordan Love did not miss practice because of injury and is ready to play
The impact of 'AI' on political ads
Host and the Panel discuss a myriad of topics leading up to the midterms. Topics included Pennsylvania as the quintessential 'purple state'; how the races in the collar counties are leaning, fostering voter engagement and how 'AI' is changing the game in the political advertising.
New directorships provide crucial support for Vanderbilt Health’s missions
The most recent Vanderbilt Health directorships are spread throughout many departments — highlighting individuals who make an impact in myriad ways.
Trump exempts some Canadian imports from his 50% tariffs
Plywood sheets, packing crates and some machinery are among the exempted products
No designation for Matthew Golden
Packers WR Matthew Golden was a limited participant this week but is not on injury report
Stories to cover as insurance costs continue to outpace wages, inflation
This year, U.S. workers are once again facing rising health insurance costs, continuing a trend that has persisted for decades, according to KFF’s 2026 Employer Health Benefits Survey, published yesterday, Oct. 22.
Giants Draft Pick Makes Immediate Impact in Pro Debut
San Francisco Giants 17th-round pick Tanner Mally carried his elite college hitting into professional baseball.
Montgomery County Precinct 4 to open new park
Montgomery County Commissioner Precinct 4 will open Granger Park in Conroe on Oct. 29 with a walking trail, children's play features and a ribbon cutting.
WATCH: NFIB warns of small business exodus unless voters repeal income tax
(The Center Square) - The National Federation for Independent Business is sounding the alarm about impacts on small businesses in Washington if the recently passed income tax remains in place.
Ahead of GTA 6, PlayStation 5 Sales Were Up 22%, Likely Due To Wolverine
The latter part of 2026 has been packed with excellent games, all leading up to GTA 6 on November 19, so it's not surprising that PS5 sales have jumped over last month.
Scientists uncover the molecular pillars that shape our cells' powerpacks
Mitochondria are the tiny powerpacks that supply most of the energy our cells need. Their ability to generate this energy relies on a distinctive architecture: two membranes, one tucked inside the other, ...
Packers' Zaire Franklin Ruled Out vs. Lions
A rare injury blow sidelines the Packers’ defensive workhorse for Sunday’s divisional clash.
Public Health Alum Enjoys Making Impact in the Realm of Health Administration
Daniel McFarland embraces the opportunity to help the masses through his role as chief operating officer for Baptist Memorial Hospital.
When health changes your sex life, intimacy doesn’t have to disappear
Aging and illness can impact intimacy. The Aging Untold experts are sharing practical ways for couples to talk openly and safely navigate sex after a diagnosis.
When health changes your sex life, intimacy doesn’t have to disappear
Aging and illness can impact intimacy. The Aging Untold experts are sharing practical ways for couples to talk openly and safely navigate sex after a diagnosis.
Trump administration sues to block Alaska Senate certification if Republican Sen. Dan Sullivan loses in November
The Justice Department said the presence of two Dan Sullivans on the ballot makes it “vital” that the state “not certify any election result that may be impacted by voter confusion.”
How Can I Hang On To My Digital Life?
I’ve been watching the “available storage” bars on my various digital storage systems creep up over the last couple years with a growing sense of dread. Each percentage point is a tick closer to an upgrade to my package—money I’ll have to pay Apple, Google, and Dropbox to continue to store my digital life. Maybe…
‘A pending public health crisis’: Minnesota community health clinics brace for Medicaid changes and more uninsured patients
Community health centers statewide are reporting that thousands may lose coverage, adding further strain to an already stressed health care system. Southside Community Health Services is preparing for the financial and health impacts of sweeping Medicaid changes.
World Series in Milwaukee impacts high school sports, Bucks home opener
High school football and the Milwaukee Bucks are making changes to accommodate the Brewers and sports fans.
Humble ISD to unveil 'Magic Science Lab'-themed playground at Ridge Creek Elementary
Humble ISD will celebrate the opening of a new Magic Science Lab-themed playground at Ridge Creek Elementary on Oct. 27.
SpaceX's Launch Business Wasn't Profitable Last Quarter, but Here's the Hidden Upside
The space segment is doing more for SpaceX than its raw revenue numbers indicate.