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Science Note: Air Pollution and Human Reproduction
Fine particulate air pollution, or PM2.5, has been linked to many health consequences such as cancer, respiratory diseases, and cardiovascular damage. Now researchers are finding connections between exposure to this air pollution and longer menstrual cycles. Ashanti McLean reports in this note on emerging science how period tracker app data helped make the link.
Flu cases rise early in El Paso County as public health officials monitor respiratory illnesses
Increases in flu typically begin around Thanksgiving.
UM Health-Sparrow offers $40,000 in loan repayment to nursing, respiratory therapy students
University of Michigan Health-Sparrow is working to address the growing shortage of nurses and respiratory therapists in Mid-Michigan by offering eligible students up to $40,000 in loan repayment.
NYC Health + Hospitals Encourages New Yorkers to Receive Their Annual Flu and Covid-19 Vaccinations during Respiratory Virus Season
NYC Health + Hospitals today announced that the 2026–2027 updated influenza and COVID-19 vaccines are now available for patients at its hospitals and
New Mexico Dept. of Health: Respiratory diseases on the rise across state
NEW MEXICO (KRQE) — The New Mexico Department of Health says it’s seeing an increase in respiratory disease rate, including COVID-19, influenza (flu), and RSV, across the state. “Last season,…
Burning through Türkiye's GDP: The high cost of fossil fuel PM2.5 pollution on public health – Centre for Research on Energy and Clean Air
Türkiye’s reliance on fossil fuels is generating massive air pollution health costs both within the country and throughout the region. This report finds that fossil fuels account for more than half (52%) of Türkiye’s population exposure to PM2.5 air pollution. The cumulative health impacts are estimated to cost the Turkish economy approximately USD 55 billion each year, equivalent to 4.1% of national GDP in 2024. The pollution is also responsible for roughly 26,500 deaths per year in the country, including deaths from cardiovascular and respiratory diseases, lung cancer, stroke, and diabetes.The impacts begin at the very start of life, with fossil-fuel-derived PM2.5 pollution contributing to an estimated 8,000 preterm births, 8,200 low-birthweight infants, 5,100 new cases of childhood asthma, and 6,500 emergency-room visits for asthma each year in Türkiye.Beyond the estimated deaths each year in Türkiye, air pollution from the country’s fossil fuel emissions also contributes to deaths and economic losses in neighbouring countries. In 2024, these emissions were estimated to cause: 32,000 deaths and USD 2.1 billion in economic burden in Egypt; 1,700 deaths and USD 0.2 billion in economic burden in Syria; 800 deaths and USD 0.8 billion in economic burden in Iraq; 500 deaths and USD 4.5 billion in economic burden in Israel; and 400 deaths and USD 1.5 billion in economic burden in Greece.Türkiye currently has no national ambient air-quality standard for PM2.5, despite the substantial health burden associated with exposure to the pollutant. Figure — The percentage of annual PM2.5 emissions in Türkiye’s fossil fuel emissions, using the EMEP emission inventory and EMEP MSC-W chemical transport model Key findings Türkiye’s fossil fuel emissions (from domestic sources as well as international aviation and shipping) account for 52% of population exposure to PM₂.₅ nationwide. PM2.5 pollution attributable to Türkiye’s fossil fuel use is responsible for approximately 26,500 deaths in the country every year, including deaths from cardiovascular and respiratory diseases, lung cancer, stroke, and diabetes. Children are among the most affected, with fossil fuel-derived PM2.5 pollution contributing to an estimated 8,000 preterm births, 8,200 low-birth-weight infants, 5,100 new cases of childhood asthma and 6,500 emergency room visits for asthma each year. The cumulative health impacts of fossil fuel-derived PM2.5 pollution are estimated to cost the Turkish economy approximately USD 55 billion each year, equivalent to 4.1% of national GDP in 2024. Transboundary pollution attributable to Türkiye’s land-based fossil fuel emissions also leads to thousands of deaths in five neighbouring countries, with estimated economic burden per year (as of 2024) reaching USD 2.1 billion in Egypt (3,200 deaths), USD 0.2 billion in Syria (1,700 deaths), USD 0.8 billion in Iraq (800 deaths), USD 4.5 billion in Israel (500 deaths), and USD 1.5 billion in Greece (400 deaths). Türkiye currently has no national ambient air quality standard for PM2.5, despite the substantial health burden associated with exposure to the pollutant. Reducing fossil fuel use and emissions across Türkiye’s energy, transport and industrial systems would deliver substantial air quality and public health benefits by reducing exposure to PM2.5 and preventing associated illness and deaths. Figure — Annual deaths attributable to Türkiye’s land-based fossil fuel emissions in the five most affected countries, based on 2024 emissions
What Pharmacists Should Know About Sea Buckthorn for Respiratory Health
Sea buckthorn is a commonly used herbal for respiratory health—US pharmacists are knowledgeable in educating patients on herbals, especially during the cold season.
Utah DCC to Help Lead Data and Analytics for National Study of Childhood Viral Infections
The DCC will integrate information collected by a consortium to study why viral respiratory infections affect children differently.
Public health officials recommend vaccinations for respiratory illnesses
Cold weather is closing in on North Dakota, and so is flu season. Now’s the time to get ahead of illness by getting vaccinated.
Flu activity is rising earlier than usual in El Paso County, health officials say
Respiratory illness season is underway in El Paso County, and local health officials say flu activity is already increasing earlier than typically expected.
Essentia Health Highlights Importance of Knowing Care Options
Essentia Health urges patients to choose the right care setting this respiratory virus season, noting about 25% of ER visits are avoidable.
Morocco health alert issued due to diphtheria: US Embassy
In the North African country of Morocco, the country’s Ministry of Health reported a small diphtheria outbreak with clusters in multiple regions in Morocco in late September. Moroccan health teams are tracing contacts and providing preventive treatment and vaccines. This has prompted the US Embassy to issue a health alert for U.S. citizens in Morocco. Diphtheria is a serious bacterial infection. It spreads primarily from person to person through coughs and sneezes (respiratory droplets). Most Americans were vaccinated as children and have received Td or TdaP boosters as adults. The risk to U.S. citizens in Morocco remains low. U.S. Citizens may contact their local doctors if they would like immunizations. Embassy officials advise citizens to watch out for the following symptoms: Sore throat or hoarse voice, mild fever, a thick gray or white coating in the throat or nose, swollen neck and trouble swallowing or breathing. If you or a family member has trouble breathing or swallowing, please contact your local doctor. They also advise on the following actions concerning vaccines: Check your vaccination records and your family members’ records. Get a booster if you need one. Adults need a diphtheria booster (Td or Tdap) every 10 years. Make sure your children are up to date on their routine vaccines. Outbreak News Today is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe
Seoul National University of Science and Technology Researchers Show How Smartphones Can Help Detect Lung Problems in Children
/PRNewswire/ -- Respiratory disease in children is a major global concern. Although stethoscopes help clinicians detect abnormal lung sounds, access to...
Cook County Public Health encourages vaccinations as respiratory illness season approaches
As temperatures drop and residents spend more time indoors, Cook County Public Health and Human Services is reminding residents to get vaccinated against influenza and COVID-19. Respiratory illnesses become more common during the colder months as people gather indoors, increasing opportunities for viruses to spread. “From a public health perspective, this is a good time to...
ECU Health Pediatric Asthma Program warns fall can cause flare-ups: Q&A with Bailey Hattem Edwards
Bailey Hattem Edwards, respiratory care manager and program lead for ECU Health’s Pediatric Asthma Program, sat down for a Q&A.
Mayo Clinic Minute: Wash your hands for better health
Note: Oct. 15 is Global Handwashing Day As respiratory infections rise in the fall months, washing your hands with soap and water is more important than ever. Regular hand-washing stops germs from spreading and lowers your chances of getting sick. Always wash your hands after using the bathroom, before eating or cooking, and after coughing or sneezing. Washing your hands for […]
RFK Jr.’s Chimpanzee Conspiracy Theory
The health secretary believes that a common respiratory virus leaked from a government lab.
Health information sources show links to RSV vaccination among older adults in Japan
Respiratory syncytial virus (RSV) causes substantial morbidity among older adults; however, RSV vaccination remains limited in Japan. Identifying effective information channels to promote RSV vaccination ...
Aged aircraft exhaust poses a rising threat to human health
Fine particulate matter consists of tiny particles with diameters in the nanometer range. They are produced, for example, by fuel combustion, remain suspended in the air and can penetrate deep into the respiratory tract.
Essentia Health highlights importance of knowing care options
As respiratory virus season approaches, Essentia Health is reminding patients to know their options for receiving care and avoiding unnecessary — and often more expensive — trips to the emergency room.
Vatican gives Pope Leo health update following surgery
Pope Leo XIV is eating, walking and has begun respiratory exercises after surgery to remove a cancerous mass, the Vatican said.
Public health leaders say now is the time for vaccinations
Public health leaders in Washington, Oregon, California and Hawaii have released vaccine recommendations for the respiratory virus season.
438 Alexandria Students Step Inside the World of Health-Care Careers
Inova professionals introduced 438 Alexandria City High School students to health-care careers ranging from chemotherapy and surgery to respiratory therapy, radiology and nursing.
Fall allergies or a viral illness? Know the key symptoms
As fall allergy season overlaps with cold, flu and other respiratory viruses, learn how to tell the difference between allergies and illness, when to seek treatment and how to stay healthy.
State encourages residents to stay updated on flu, COVID vaccines as virus activity increases
Hawaiʻi Department of Health encourages residents to take common-sense precautions against influenza, COVID-19 and other respiratory viruses as respiratory virus activity increases throughout the state.
Art Garfunkel, 84, postpones tour due to respiratory infection
Art Garfunkel is reportedly postponing his upcoming tour.
HOMETOWN HEALTH: Cleveland Clinic doctor says influenza A cases are higher than expected for October
Respiratory viruses commonly begin appearing in the U.S. in October, but the season tends to peak between December and February.
HOMETOWN HEALTH: US lags on RSV vaccine for pregnant women as respiratory virus season begins
Pregnant women are recommended to receive the vaccine in their third trimester to help protect babies during the first six months of life.
Health Officer issues mask order in specified health care facilities, encourages residents to get vaccinated for flu and COVID-19
To protect against the elevated risk of respiratory virus-related illnesses, such as COVID and flu, during the fall and winter, Sonoma County’s Health Officer Dr. Mia Shim issued a health order requiring health care personnel and others to mask in patient care areas of specified health care facilities. The health order, designed to protect the most vulnerable people in our community, will be in effect from Nov. 1, 2026 through March 31, 2027.
Measles cases adding to concerns as healthcare systems brace for flu, COVID and RSV season
In addition to measles, the season of respiratory viruses is here. Dr. Michael Apostolakos said he hopes more people get vaccinated and take preventative steps to avoid getting sick and ending up in a hospital.
CCDPH Launches “Spread Facts, Not Flu & COVID” Campaign Ahead of Respiratory Virus Season - Cook County Department of Public Health
Today, Cook County Department of Public Health launched Building Healthier Communities 2030, suburban Cook County’s Community Health Improvement Plan. The plan was announced together with Cook County Board President Toni Preckwinkle, Cook County Department of Public Health, community organizations, healthcare providers and cross-sector partners. Building Healthier Communities 2030 serves as both a collective vision and a practical roadmap that will guide public health efforts across suburban Cook County through 2030.The plan aligns with President Preckwinkle's Policy Roadmap and reflects a shared commitment to advancing health equity through coordinated, community-informed action.
Health officials urge flu shots as Brown County sees early rise in hospitalizations
Officials are urging people to get a flu shot as respiratory virus season begins.
Health Alert – U.S. Embassy Moscow, Russia (October 6, 2026)
Health Alert – U.S. Embassy Moscow, Russia (October 5, 2026) Location: Irkutsk, Russia Event: The U.S. Embassy is aware of press reports from the Irkutsk region of suspected pneumonic plague resulting in the death of an individual and of associated quarantine measures in, and closures of, hospitals in Irkutsk. We continue to track the situation closely. The U.S. government has limited ability to help U.S. citizens in Russia, especially outside of Moscow. U.S. government personnel may face additional restrictions for personal and official travel to specific regions due to health and security concerns. The State Department’s Level 4 Travel Advisory (Do Not Travel) for Russia remains in place and states U.S. citizens currently in Russia should depart immediately. U.S. citizens planning travel to Russia are again strongly advised not to travel to Russia due to risk of wrongful detention and security concerns. Actions to Take: S. citizens in the area should follow the guidance of local health authorities, avoid affected facilities, and seek medical care promptly if they develop fever or respiratory symptoms. Visit the CDC Page on Plague for additional information about the disease. Visit the CDC Travelers’ Health Page for Russia for country-specific health updates. Monitor your health for 14 days following travel if you traveled to an area experiencing the outbreak. Review the S. Embassy country page for general health information. Refer to the Embassy’s list of medical providers. Check with your travel insurance provider about medical evacuation options should you fall ill while overseas. Have a plan to depart in an emergency that does not depend on U.S. government help. Monitor local media for updates. Be prepared to adjust your plans. Enroll in the Smart Traveler Enrollment Program(STEP) to receive health and security updates. Assistance: U.S. Embassy Moscow, Russia +7 495 728-5577 MoscowACS@state.gov U.S. Embassy Moscow web page State Department – Consular Affairs (+001) 888-407-4747 or (+001) 202-501-4444 Russia Country Information Follow us on Facebook and Twitter State Department – Consular Affairs 1-888-407-4747 or 1-202-501-4444
Alexandria health officials issue vaccine guidance as respiratory illness season begins
As the season for increased flu and other respiratory illnesses arrives, the Alexandria Health Department is providing guidance on vaccines and other recommendations for residents. Flu season begins in October and continues until May, although activity may peak in the winter months. Other respiratory illnesses such as COVID-19 and RSV (respiratory syncytial virus) also circulate during
Pennsylvania passes 1,000 measles cases as PA health secretary says CDC is minimizing five measles associated deaths
Pennsylvania Health Secretary Dr. Debra Bogen visited a Pittsburgh pharmacy to raise awareness about respiratory illnesses, including COVID-19 and the flu, while addressing the state's rising measles cases.
EU Screening Week 2026: Healthy Lungs for Life activities took lung health checks to communities across Europe
The European Lung Foundation (ELF), European Respiratory Society (ERS) and health partners across Europe ran Healthy Lungs for Life events to take part in the first-ever EU Screening Week, a European Commission initiative that promotes prevention, early detection and health education.
Alexandria Health Department no longer offering free COVID-19, flu tests
The department is providing flu shots only to uninsured residents and has issued guidance for the respiratory virus season
HEALTH MINUTE: PREVENTING DANGEROUS RSV IN INFANTS
We’re officially in respiratory virus season. The U.S. Centers for Disease Control and Prevention says it typically runs October through mid-May, and the agency expects the U.S. will see a
Health Agency says now is the time to update raspatory virus Vaccinations
COLDWATER, MI (WTVB) - As fall arrives and respiratory virus season gets underway, the Branch-Hillsdale-St. Jo...
Health officials order Pearl City junkyard to cease operations after fire
The Hawaii Department of Health has ordered a Pearl City junkyard to cease operations immediately after a Wednesday afternoon fire sent heavy smoke throughout the area and prompted a state warning to residents with respiratory conditions to take precautions.
Emory Healthcare enforces annual flu shot requirement as respiratory illness season begins
CMRHD Public Health Topics: October 2026
The Central MA Regional Health Dept. is pleased to feature four public health topics for the month of October 2026: Respiratory Illness Season, Domestic Violence, Breast Cancer Awareness, and Hallowee
Oregon health officials urge vaccinations ahead of respiratory virus season
The Oregon Health Authority anticipates a potentially severe season for illnesses, including influenza, RSV and COVID-19.
New proclamation highlights respiratory health awareness across Phoenix, Arizona
At the request of the American College of Chest Physicians (CHEST), the City of Phoenix and Mayor Kate Gallego officially proclaimed October 18, 2026, as Love Your Lungs Day for Phoenix, Arizona.
Dr. Elizabeth Murray shares health tips for winter respiratory season
California firm licenses ‘potent’ anti-measles antibodies from Vanderbilt Health for development, clinical testing
Further development could lead to the first monoclonal antibody therapy against the highly infectious measles respiratory virus.
Essentia Health hosting vaccine clinics ahead of respiratory virus season
As we move into fall, Oct. 1 marks the unofficial start of the respiratory illness season. This is typically when the Centers for Disease Control and Prevention (CDC) starts to see an uptick in reported cases of influenza, RSV and COVID-19.
Get flu and COVID shots before the end of October, public health officials say
Respiratory virus season is on its way, and health officials say it’s time to schedule seasonal vaccines for flu and COVID-19.
Cottage Health Hosts Sepsis Conference Focused on Early Recognition and Treatment
Cottage Health brought together physicians, nurses, pharmacists, respiratory care practitioners and other clinicians from across the region on Friday,
What to know about COVID-19 and flu vaccines in Minnesota this fall
Medical professionals highly recommend vaccines for both children and adults as respiratory illnesses begin to rise across Minnesota.
Beyond the flu shot: health experts urge protection against multiple respiratory viruses
As respiratory virus season approaches, health experts are urging Americans to look beyond the annual flu shot and take a broader approach to seasonal immunization.
Health experts urge vaccinations as respiratory illnesses begin to rise across Chicago area
As temperatures cool and children return to school, health experts say respiratory illnesses are beginning to increase across the Chicago area, prompting renewed calls for flu and COVID-19 vaccinations ahead of the fall and winter seasons.
UAFS makes progress toward offering respiratory therapist program
The University of Arkansas at Fort Smith (UAFS) said Tuesday (Sept. 22) it is making progress on plans to offer an associate of applied science degree (AAS) in respiratory therapy,...
Ask the Pediatrician: How to protect children and teens with chronic health conditions
Influenza (flu) is an infection caused by the influenza virus that infects the respiratory tract inc...
Ask the Pediatrician: How to protect children and teens with chronic health conditions
Influenza (flu) is an infection caused by the influenza virus that infects the respiratory tract inc...
Wildfire Smoke causes greater health risks than other air pollution
Wildfire smoke poses greater health risks than other air pollution, with studies linking to cancer, cardiovascular and respiratory outcomes.
Free flu and COVID vaccine clinics start this week in Boston
“Vaccination is the safest and most effective tool we have to reduce the risk of serious illness from respiratory viral illness, like the flu."
The Big Holes in Wearable Heart Rate Variability And Readiness Scores
On September 9th, Apple announced it was revamping its Apple Watch Health Sensing System, rolling out a Readiness score (0 to 10), and increasing the frequency of heart rate variability (HRV) outputs 24-fold. This can be viewed as upping its competition with various other consumer wearable sensors. These “readiness scores” as a composite of multiple metrics, with heart rate variability (HRV) being front and center for most. The majority of Americans are now using wearable sensors, which equates to well over 100 million adults. HRV and Readiness scores are increasingly being marketed as a measurement of autonomic nervous system health, a digital marker for future disease, a clock for biological age, and a holistic metric to promote healthspan and even longevity. (Apple also introduced a new longevity tab and “Health Age”.) None of this has been proven. In this edition of Ground Truths I am going to review what we know about heart rate variability and readiness scores. Heart Rate Variability HRV is the variation in normal heart cycle timing. The variability of the heart rate, the barely perceptible millisecond changes in time between consecutive heart beats (see R-R intervals in the Figure below, left panel), is due to interplay between the sympathetic and parasympathetic (vagal nerve) inputs. Distinct from heart rate, individuals with the same heart rate can have very different HRVs. It is a rough reflection of the autonomic nervous system (ANS) activity, inadequate to say whether a person’s ANS function is abnormal. For more than three decades, heart rate variability (HRV) has been measured and several studies have found an association of low HRV and clinical outcomes, particularly a link with higher all-cause and cardiovascular mortality. There have also been less well established links of low HRV to risk of early cognitive impairment, dementia, mental illness, Type 2 diabetes and substance abuse. An important reminder is that HRV is a surrogate marker without any established cause-and-effect relationship. If you increase your HRV, that doesn’t mean it will improve health outcomes. In fact, there is no hard evidence for that. All that work linking to health outcomes was done with electrocardiogram (ECG) derived HRV. Now, in the era of consumer wearables, this is getting assessed differently, by optical pulse (yes, the lights you see) plethysmography (PPG) or what is called pulse rate variability (PRV). They are not the same, as shown below (right panel) and only concordant when the delay between the ECG and pulse is kept constant, which basically means at rest. I should mention there’s also what I will call MPV, a mattress mechanical movement sensor, a derived heart rate variability, that companies like Eight Sleep use, even further away from directly measuring HRV. HRV has not one uniform measurement but many different types of quantification, such as RMSSD, the magnitude of difference between successive R-R intervals of normal sinus beats (N-N) or SDNN, the standard deviation of NN intervals, both in milliseconds. SDNN is one of the so-called frequency domain HRVs (others are LF, HF, LF/HF). Different wearable sensors use different metics; Apple has relied on SDNN and nearly all of the others use RMSSD, which is generally considered the more accurate metric. There’s also the different length of time measured, such as for a matter of minutes, all day, or an overnight’s sleep. Short measurements are especially problematic since they don’t capture enough of respiratory modulation and other factors that influence HRV. Share Ground Truths How well does HRV correlate with PRV? There are very limited studies, especially independently done. One that is commonly cited was conducted by Air Force researchers in only 13 healthy adults assessing Oura ring 3 and 4, Whoop 4.0, and Garmin Fenix 6 and showed a correlation coefficient of 0.88 to 0.97 and a mean absolute percentage error from 6 to 10%. The correlation is not a perfect 1.0, but there’s at least a fairly high level of correlation. HRV is supposed to increase during the night due to takeover of the parasympathetic nervous system, and higher during deep sleep. A recent example of my 1 week, all day “HRV,” and one during sleep is shown below. As you can see, the N of 1 data are inconsistent for the same days from different sensors (Oura, AppleWatch, Fitbit Air, and Eight Sleep) by patterns, absolute numbers, and comparison with prior days and weeks. The largest study in over 8 million Fitbit users (the old version, not Google Fitbit Air, introduced in May 2026) gives you a sense of the effect of age, sex, and the 2 different main HRV (here PRV) metrics, with RMSSD on the left and SDRR (=SDNN) on the right below. That study, from data collected in 2018, is a major outlier, since all the more recent ones are tiny with respect to sample size. Many of the companies have not had independent evaluation of their HRV, such as Eight Sleep, but have published a low standard error on their website. There are some other published studies on the correlation between HRV and PRV, but they are all small and only in healthy adults. A scoping review emphasized the lack of study in underrepresented individuals, including the aged, people of color (which affects the PPG signal), and individuals who are underweight or obese. Add the typical adult age 60 plus with one or more chronic diseases. For example, one study in over 900 adults found poor correlation of HRV and PRV, non-uniformly underestimated across many chronic diseases (cardiovascular, endocrine, neurological, respiratory, and others), concluding PRV is “an invalid surrogate for HRV.” A recent systematic review of 43 studies comparing HRV and PRV found reasonable pooled absolute standardized error (HRV as gold standard) but only 10 of the studies provided quantitative synthesis in ideal conditions. Their main conclusion was similarly cautious: “PPG-derived HRV [PRV] should not be regarded as universally interchangeable with ECG-derived HRV across all devices, populations, and recording contexts.” Factors Affecting HRV and PRV That gets me to the long list of factors that affect HRV (and PRV) besides the device, the type of measurement (RMSSD, SDNN or others), the person’s signal, the sensor site, the duration of data capture, if weighting by sleep stage is used, how artifact is processed and corrected. And this list is not complete!: Oura puts out data from their community of users (who input data) on what affects their overnight HRV. The factors currently provided are: no alcohol (increase 8%), melatonin (increase 2%, float tank (increase 2%), wine (decrease 4%), and party (decrease 14%) in overnight HRV. Must be some big parties! Subscribe What is a PRV measurement good for? It has been falsely characterized as an index of “autonomic balance” and a specific indicator of stress. A 2018 review of the studies available for HRV and its relationship to stress, not using any of the current wearables, found that stress can lower HRV. But so can many other factors. The non-specificity of the signal, indexed to the table above, is striking. Evidence from a UK Biobank study of over 46,000 participants with actual HRV looked at genetically predicted HRV, a genetic risk score, that failed to show the expected HRV-mortality link, indicating that _HRV is likely not causa_l, but rather a reflection of person’s physiologic state. A review of consumer wearable HRV data from 5 longitudinal studies showed that nighttime PRV was not associated with perceived stress, and surprisingly higher HRV, in the largest cohort (N=717 participants), was correlated with higher stress. An Oura ring cohort of 525 first-year college students found a link between overnight PRV and perceived stress, but that was also seen with resting heart rate, sleep, and respiratory rate. Several very small studies have examined the relationship of HRV and athletic injuries or guiding training with mixed, and predominantly negative results. HRV biofeedback training with paced breathing had no significant effect on reducing stress or raising HRV, as demonstrated with sham controlled trials. When HRV for multiple days showed a decline in conjunction with body temperature, the Oura ring published data for prediction of Covid. The WHOOP company sponsored an observational study, published in 2026, of 30,000 users for 72 weeks, without a control group, that reported reduced alcohol intake (5.8 % points) by self-report. That doesn’t tell us much, and particularly about the merits of HRV for behavioral change. If you use the same device and conditions as longitudinal trends for multiple (at least 2-3) weeks that may be the one way to get something useful from the measurements. Data for overnight sleep with minimal motion and using RMSSD is the best proxy for real HRV. The reason to look at trends rather than any given night is that it more likely represents something, even though you won’t know with certainty what the “it” is. Keep in mind there are no data, no peer-reviewed evidence, to show that HRV fluctuation in-person has any correlation with health outcomes. Share Readiness Scores These are proprietary scores that integrate different metrics for each of the wearables: no algorithms have been disclosed. They are unvalidated against health outcomes. In a review of 14 composite health scores of readiness and recovery, HRV contributed 86% to the scores, followed by reading heart rate (79%), physical activity and sleep duration (both at 71%). That review noted the substantial variability in measurement protools and lack of standardization. Sleep staging is notoriously inconsistent and inaccurate by these sensors, which adds further to the HRV uncertainties for what the scores, which use sleep stage data, mean. Only resting heart rate has been shown consistently across devices to be extremely accurate. I’ve made a Table to summarize what we know about which metrics are included, the scores, any peer-reviewed studies that compared the readiness score with health outcomes, and the corresponding (if any, NA-not available) citation. You will note that some companies do not use the term “readiness," such as WHOOP for recovery, and Garmin, which has 2 different scores, one of which is Body Battery. Eight Sleep uses the term “Fitness Score.” They all include HRV; Apple includes a new metric they call “Recovery HRV” which among other components uses 7-days of sleep, but it is unclear what this means or how it is differentiated from other scores (there are clearly no data for outcomes). We have no knowledge of how the different components are weighted or whether any of these scores are better than resting heart rate, HRV alone, physical activity, or any other single metric. Since none of these are standardized, they are not interchangeable, so if you get a 90 for Oura that has no relationship to a 90 on a Google Fitbit Air. Notably, the company can update its algorithm for readiness score at any point without notification to device users. Without any useful evidence of actionability for these scores or established relationship with health outcomes, it is hard to make a case for their value. At the Apple recent announcement they showed their Readiness score (0-10) on the watch (Figure below) but there are no published data on this score, not even on their website. It’s available only on their new Watch Series 12 or Ultra 4 [of course, ;-)]. That exemplifies the problems with these scores, lack of data and evidence for being meaningful to promote health. Perhaps the best study (which isn’t saying much) is the WHOOP Recovery for golfer performance, because it did correlate with an objective outcome, even though there was no control group and the authors were all from the company. Among the 389 pro golfers, an absolute 10-per cent point increase in Recovery score was associated with about 0.5 fewer strokes per round. But that’s hardly a health outcome! WHOOP is also conducting a study in over 2,700 runners to see if their recovery score will be linked to less injuries and improved performance, but that is not yet published and has no control group or randomization. Putting This in Context For two decades I’ve been enthusiastic about the potential for digital health and particularly wearable biosensors. Over the years, we’ve seen some great progress for their ability to promote physical activity and accurately detect atrial fibrillation (the first FDA cleared deep learning AI for consumers). That work was the subject of rigorous research. But there are holes in the data and evidence for other metrics. One notable one is the “VO2 max” story that I wrote about earlier this year. At that time many subscribers asked me to cover heart rate variability, which I finally got to here. When I dived into the research and publication for HRV and readiness scores, I expected to find at least some that were of high quality and demonstrated their utility by linkage to health outcomes. To my surprise, I found none. The wearable sensor measurements for HRV (PRV) are, for the most part, accurate, but that validation work has only been done in small studies of healthy adults and does not take into account the long list of factors, from the device, software side, and the user side, that affect HRV measurements. Moreover, this metric chiefly relies on optical sensing and, as we have learned for heart rate PPG sensing, may be less accurate in people of color. Keep in mind that all of the health outcome association evidence comes from ECG-derived HRV; none are from wearable sensor data. I will repeat the key point: there's no peer-reviewed evidence to show that in-person HRV fluctuation—or efforts to raise your HRV— has any correlation with health outcomes. For those of you who look at your HRV on awakening, or even 2+ week trends of it being low, I hope this context helps to relieve any anxiety. Yes, low HRV (not PRV) has been shown to increase risk of some diseases as summarized above. But efforts to raise your HRV—a surrogate metric— has not been established for improving any health outcomes. HRV does not have any evidence of causality (the genetic evidence actually goes against this possibility). In this summary, I have not included data for other wearable sensors such as Polar, Samsung, Withings, Suunto, Amazfit, Coros, Ultrahuman, or additional mattress sensors. These are beyond my first-hand experience, and as far as I know from my in-depth review none have any peer-reviewed published data that differ from the 6 sensors I’ve reviewed here. From the points I’ve gone over above, we’re not ready for readiness scores. Besides being proprietary, they are predominantly based on metrics that have their own issues. It’s compounding the problem, like building a house without a solid foundation that has never undergone a rigorous inspection, and then selling it. Like I mentioned for PRV, you can look at trends over weeks rather than any single day, to get a handle, but even that may not be helpful. There’s simply no evidence that these scores meaningfully relate to health outcomes. I’d emphasize they might, but that requires doing prospective or randomized studies to prove it. None exist. There’s great promise for HRV/PRV utility_. For example**,**_ Prof Maiken Nedergaard, who discovered the brain glymphatics that are essential in eliminating metabolic waste products from the brain during sleep, has posited that HRV could be a non-invasive marker for neuromodulator oscillations, brain-body regulatory circuits, and brain clearance. That would be extremely useful, but like everything else on HRV and readiness scores it requires solid research and validation. The lay media isn’t helping much to get the story straight. Earlier this year The Economist published a piece entitled “The most useful indicator of your overall health” which ordained HRV as an “accumulated stress score.” That’s akin to the false assertion about VO2max: “V02 max is the singular most powerful marker for longevity.” As I’ve summarized here, that is not established. The fact is that so many things can lower HRV, including physical exercise (especially an intense workout), reduced sleep quality, stress, the list above, no less the device, signal, and software. Whatever fluctuations observed have not been correlated with any health outcome. Sadly, “datamaxxers” are widely using HRV and readiness scores that have never been validated to mean anything. We already know that for some people using the sensors for sleep metrics, it can induce “orthosomnia,” an obsession to get high sleep quality, with associated high levels of anxiety. In an experiment done by a company to promote sleep quality for its employees, “For those employees who did use the trackers, many reported feeling perfectly rested until their tracker told them they had had a terrible night. Others were told that they had slept like a baby when they had actually been lying awake worrying about the quality of their sleep. “ The same problem can result from preoccupation with HRV or readiness scores, with anxiety that would lead to further reduction in both. It you are using a wearable like >100 million American adults, it’s OK to look at these data, but contextualized with the major caveats reviewed here. If you are one to require evidence that HRV or readiness scores are linked to health outcomes, you may not even want to look. The companies make it hard to turn them off! Let me end with the companies that make and sell wearables. Apple’s doubling down on HRV (24-fold more reporting and heart rate very 5 seconds) and introduction of a Readiness score tells us that consumers have bought into these metrics and they are joining the club. However, all of this is occurring with a backdrop of tens millions of users, claims about the data that are not backed up by adequate evidence, marketing way out in front of whatever limited data exists, and not being transparent about their readiness score algorithms. The companies can well afford to do the research that is needed to connect these metrics with health outcomes show, once and for all, that increasing HRV or using readiness scores promotes our health. If they believed and invested in the products they are selling, we’d not be in this position of not knowing. That’s essentially where we are with HRV and readiness scores. Perhaps someday this will change and we’ll have good reason to embrace them. NB: I wrote this post. No AI. I have no conflicts of interest with any of its content. Loading... Ground Truths has 215,000 subscribers from every US state and 214 countries. There are over 300,000 followers of Ground Truths so more than 90,000 folks who can easily convert to be free subscribers. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. If you’re not a subscriber, please join! If you found this interesting PLEASE share it! Share Ground Truths The proceeds from all voluntary paid subscriptions go to support our summer internship program. It enabled us to accept and support a record number of 62 summer interns that joined us in 2026! These are high school, college and medical students selected from thousands of applicants. We couldn’t do this expanded program without the funds coming in through Ground Truths. Thank you!
Congress session highlights value of youth engagement in health
The European Respiratory Society Congress featured a special session on Wednesday 9 September, that put youth engagement in the spotlight. On the final day of the Congress, passionate youth advocates took to the stage, alongside researchers and healthcare professionals, to deliver a key message that young voices can drive positive change in healthcare.
Respiratory illness season approaches: Health experts encourage early prevention
Respiratory illnesses such as influenza, COVID-19 and respiratory syncytial virus, or RSV, return to communities every fall and winter, contributing to
Wildfire smoke poses greater health risks than other pollution
As climate change drives more frequent and intense wildfires, researchers at the Icahn School of Medicine at Mount Sinai have published two large-scale studies showing that wildfire smoke may pose greater health risks than other sources of air pollution, with higher risks of hospitalization for cardiovascular and respiratory disease and poorer survival among patients with lung cancer.
Multiple drug overdoses target Austin's entertainment district
Numerous people in and around a bar were experiencing overdose symptoms, including one adult in respiratory arrest.
Toxic red tide detected along Texas coastline — here’s how it can affect your health
A red tide bloom along the Texas coast is prompting warnings from officials as the toxic algae could cause respiratory problems for beachgoers.
UV light reveals possible camouflage on a 125-million-year-old crocodile
A 125-million-year-old crocodile fossil has revealed preserved skin, possible sensory organs, sophisticated respiratory structures, and an unexpected pattern on its tail. Ultraviolet light exposed alternating bands that may represent ancient camouflage, potentially preserving the oldest known coloration in a crocodylomorph.
Laredo Health Department offers COVID-19, flu vaccines
New COVID-19 and flu vaccines have arrived in Laredo ahead of respiratory illness season.
Minnesota health department specialist talks Asthma Peak Week
If you or someone you know lives with asthma, right now isn't just the start of fall, it's historically the most dangerous time of the year. The third week of September is known as Asthma Peak Week. Every year around this time, hospitals and emergency rooms see a spike is asthma attacks and respiratory emergencies. Andrea Hickle, the asthma program manager for the Minnesota Department of Health, joined FOX 9 News at 5 to talk about Asthma Peak Week.
Pennsylvania doctors urge children, adults to vaccinate against flu, COVID-19 and RSV as federal guidance remains thin
The beginning of the fall and winter respiratory illness season approaches as health experts deal with ongoing measles outbreaks.
Thousands Breathed Toxic Dust on 9/11—The Health Effects Are Still Emerging
Many individuals exposed to the pollution have gone on to develop multiple conditions, including cancer and respiratory disease.
CDC director’s ‘unusual’ silence draws scrutiny
Just a month into her tenure, CDC director Erica Schwartz is missing in action. The country is heading into respiratory virus season, and public guidance on COVID-19, flu and RSV vaccines has been …
Christian County Health Department Talks Vaccine Recommendations
The Christian County Health Department is encouraging community members to be vaccinated against respiratory illnesses. They highlight the flu, COVID-19, and RSV as the key conditions to be aware of, with vaccine recommendations differing by a number of factors. The health department offers the vaccines […]
Life Sciences Companies Present Live at the September 17 Virtual Investor Forum
Live Presentations and Q&A Across Oncology, Fibrosis, Drug Delivery, Antibiotics, Cannabinoid Therapeutics, and Respiratory Imaging A Global Lineup Presents Live Online: 30-Minute Sessions, Audience Q&A, Replays On Demand NEW YORK, NY - Sept...
Medical groups issue ‘science-based’ respiratory vaccine guidance
Published in JAMA, top health groups team up citing ‘major concerns’ about integrity, stability of U.S. vaccine policy for flu, COVID-19 and RSV
West Coast Health Alliance issues 2026-27 respiratory virus immunization guidance
Denver health expert shares advice ahead of start of respiratory illness increase
World Health Organization OKs Multi-dose Maternal RSV Vaccine
The new multi-dose RSV vial is expected to lower costs and simplify global distribution to protect infants from severe respiratory illness.
State health officials issue vaccine schedule amid ongoing shifts in federal vaccine guidance
Maryland health officials issued a first-ever state vaccine schedule Thursday ahead of the annual flu and respiratory illness season, under a new policy created to buck anti-vaccine messaging from the Trump administration in recent years.
Indonesian wildfires cause respiratory infections to double in a week, health ministry says
This year’s wildfire season is the most intense in 11 years as “super-El Niño” weather conditions drive up temperatures and cause punishing droughts.
Indonesian wildfires cause respiratory infections to double in a week, health ministry says
Respiratory infections caused by hazardous wildfire pollution in Indonesia have more than doubled in just over a week, data from the country's health ministry showed on Thursday.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Europe has plans for cancer and heart disease – lung health is still waiting
Getting respiratory care right could help patients, ease hospital pressure and cut emissions all at once – but Europe still lacks a plan to make it happen
Health experts track early rise in respiratory illnesses ahead of fall and winter
Labor Day may mark the unofficial end of summer, but respiratory viruses are already making the rounds as doctors look ahead to the fall and winter virus season.
West Coast Health Alliance issues immunization recommendations for 2026-2027
The West Coast Health Alliance (WCHA) is issuing immunization recommendations for the 2026-27 respiratory virus season.
Bacteria found in classroom dust may affect children’s respiratory health
Common bacteria found in classroom dust are associated with reduced lung function in children according to research presented at the European Respiratory Society (ERS) Congress in Barcelona, Spain.
California Department of Public Health Issues 2026-2027 Immunization Advisory
The recommendations highlight the importance of protecting people most impacted by respiratory viruses such as COVID-19, influenza and RSV
Signant Health, Lothar Medical Plan Integrated Respiratory Trial Device
Signant Health and Lothar Medical plan integrated respiratory trial device combining spirometry, oscillometry, and FeNO measurement into a single platform.
Santa Barbara County Health Launches Interactive Online Dashboards
Santa Barbara County Health launched three interactive public health dashboards tracking school immunizations, respiratory viruses, and communicable diseases.
HOMETOWN HEALTH: Family medicine physician outlines recommendations for flu, RSV and COVID-19
The Vaccine Integrity Project says the burden of respiratory viruses has changed since the COVID-19 pandemic.
Health record analysis of one million cattle identifies early prevention as key to reducing feedlot respiratory deaths
New research involving more than 1 million Australian feedlot cattle has found that the strongest predictors of death from bovine respiratory disease (BRD) are established before animals even enter the ...
Doctors say they’re filling a void left by CDC on vaccines. Here’s what to know about flu, Covid-19 and RSV this fall
With children back in school and the looming threat of respiratory viruses like Covid-19, influenza and RSV on the horizon, many people may now be wondering how to stay healthy.
The traditional respiratory virus season hasn’t started, but Covid is already climbing
Are you coughing, hacking or feeling feverish? It may not be just a summer cold; you might want to consider taking a Covid test.
Why Don't Insects Live in the Ocean? Scientists Just Ruled Out One Possible Explanation Thanks to Deep-Diving Fly Larvae
Researchers thought that insects might not live there because their respiratory systems would implode from water pressure. But certain fly larvae in East Africa make daily trips toward the bottom of Lake Malawi with the help of strong air sacs that contain a stretchy protein
Boyle Heights community clinic says hundreds of residents treated for "toxic exposure" after Lineage fire
Some of the most common diagnoses among Boyle Heights patients included the toxic effects of smoke, contact/exposure to hazardous substances and acute upper respiratory infection.
Measles case confirmed in western Kentucky, health officials suspect outbreak
Officials confirmed at least one unvaccinated person in western Kentucky's Christian County contracted measles, a highly contagious respiratory disease. Officials warn of several unconfirmed cases in the area too.
INOVIO Reports Second Quarter 2026 Financial Results and Recent Business Highlights
U.S. Food and Drug Administration (FDA) review of Biologics License Application (BLA) for INO-3107 as a treatment for Recurrent Respiratory Papillomatosis...
In Good Health: Why Measles Numbers Are On The Rise
Nationwide, students, teachers, and parents are gearing up for the school year.And measles is spreading. The U.S. has already logged more cases this year than in all of 2025. It’s the highest count in 35 years. That’s in large part because measles vaccination rates have slipped below 95 percent – the threshold public health experts say is needed to stop community spread. Last week on CNN, Health and Human Services Secretary Robert F. Kennedy Jr. said children should be vaccinated for measles after being pressed on-camera, even as he used the same interview to push a debunked claim about respiratory syncytial virus. And on Monday, President Donald Trump signed an executive order aimed at upending the childhood vaccine schedule, including changes to the measles vaccine and others. But what will actually change at the doctor’s office?Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Experimental Pulse Oximeter Accurate Regardless Of Skin Tone, Researchers Say
By Dennis Thompson HealthDay ReporterWEDNESDAY, Aug. 12, 2026 (HealthDay News) — Pulse oximeters became widely known during the COVID-19 pandemic, as doctors used the finger clip devices to tell whether a respiratory infection was robbing patients of needed oxygen. But skin tone impairs the ...
Sanofi suspends chronic lung disease phase 2 study, tied to ‘strategic business reasons’
Sanofi halted a phase 2 trial testing a monoclonal antibody, SAR445399, in non-cystic fibrosis bronchiectasis, Fierce Biotech has learned. The trial, which began only back in April, was a randomized, double-blind, placebo-controlled study to measure the reduction in mucus plug score following treatment with SAR445399 compared with placebo in adults aged 18 to 80 years with NCFB, a chronic lung disease. The trial was officially reported as halted on July 29, the day before Sanofi’s second-quarter earnings call. The decision to pause the trial was made “as part of a company-wide portfolio review for strategic business reasons,” and not due to safety concerns, a Sanofi spokesperson told Fierce. The move to pause the NCFB trial comes during a trying time for Sanofi following a year filled with a series of trial fails. In February, the French pharma ousted CEO Paul Hudson and appointed Merck KGaA leader Belén Garijo, M.D., Ph.D., to steer the ship. Since then, Garijo has been doing a deep dive on correcting the company’s strewn R&D and clinical strategies. On July 24, Sanofi scrapped amlitelimab for atopic dermatitis, despite its lore as being a potential $5 billion blockbuster. During its second-quarter report, the company abandoned two more assets, balinatunfib and itepekimab, following failed trial results in psoriasis and chronic obstructive pulmonary disease, respectively. SAR445399, only first revealed by Sanofi in 2023, is an anti-interleukin-1 receptor 3 monoclonal antibody developed to block the interleukin 1, 33, and 36 cytokine pathways. These pathways can be important in chronic immune-related dermatologic diseases, such as atopic dermatitis and hidradenitis suppurativa, as well as respiratory conditions, such as NCFB. Related Sanofi’s new CEO ‘looking deeply’ at late-stage pipeline as clinical clearout continues NCFB affects roughly half a million people in the U.S., with a global incidence of greater than one million cases. In August 2025, Insmed received FDA approval for Brinsupri, a DPP1 inhibitor targeting neutrophil activation, for treatment of NCFB in adults and kids ages 12 and older. The British biotech Infex Therapeutics showed promising NCFB phase 2a data using their monoclonal antibody, INFEX702, which acts by disabling Pseudomonas aeruginosa, a bacteria known to be a major pathogen of NCFB. Sanofi is currently running a separate phase 2 study testing SAR445399 as a potential treatment for the inflammatory skin condition hidradenitis suppurativa.
How can wildfire smoke affect your health? Respiratory Care faculty explain
Recent wildfire smoke has engulfed the Treasure Valley, bringing the Air Quality Index into the...
Temporal Changes in Pediatric Influenza Test Positivity Across COVID-19 Public Health Policy Phases: A Five-Year Retrospective Cohort Study
Background The COVID-19 pandemic coincided with substantial changes in respiratory virus circulation, healthcare utilization, and diagnostic testing. Although population-level influenza activ...
Albuquerque-Bernalillo County Air Quality Program issues health alert due to ozone
ALBUQUERQUE, N.M. (KRQE) – The Albuquerque-Bernalillo County Air Quality Program issued a Health Alert on Saturday due to ozone. Those with respiratory conditions in the city and Bernalillo County …