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Galaxy S24 and Fold 7 get Galaxy S26 AI features with latest One UI 8.5 beta
Samsung is making good on its promise to bring new Galaxy AI features from the Galaxy S26 lineup to existing devices. It has released new One UI 8.5 beta updates today that include these features for several devices, including the Galaxy Z Fold 7 and the Galaxy S24 series. The Galaxy S25 series has also […]
Scientists unveil how heat-loving enzyme could help improve plastic recycling
Cutinases are fungal enzymes that naturally degrade plant cuticles and show promise for recycling plastics. However, they must balance structural rigidity to withstand high temperatures with flexibility required for catalysis. Now, researchers have investigated the structural basis of catalytic activation in a heat-tolerant cutinase, CtCut, from the fungus Chaetomium thermophilum and found that a rigid core supports stability while a flexible lid is associated with catalytic function, offering insights for improving enzymes for plastic recycling.
This Week in Politics: A compromise on taxing the rich in New York | WNYC | New York Public Radio, Podcasts, Live Streaming Radio, News
Gov. Hochul announced a proposal to impose a new tax on second homes in New York City valued at $5 million dollars and more.
Slay the Spire 2 roadmap suggests we won't get matchmaking but does promise "whimsy"
It's been a little more than a month since Mega Crit's hugely anticipated sequel Slay the Spire 2 released in early acc…
Some health AI tools worsen admin burdens, but backers still see promise
Backers still see promise.
Starmer rejects calls to quit as pressure mounts over Mandelson vetting
Top Foreign Office official takes fall for fiasco and resigns; Starmer promises to deliver 'relevant facts' on Monday.
Micro RGB TVs Were Everywhere at CES, but TCL's QM8L Could Put Them to Shame
The Super Quantum Dots of TCL's 2026 TV range promise more colors and brightness than ever.
NSWCPD Applies AI and Machine Learning to Predictive Machinery Health
In a soundproof chamber at the Naval Surface Warfare Center, Philadelphia Division (NSWCPD), a steel-gray air compressor hums as engineers test an experimental machine learning model designed to detect early signs of failure through vibration analysis. The effort, part of NSWCPD’s growing portfolio of artificial intelligence (AI) and machine learning (ML) projects, shows early promise for potential future Navy use.
Zohran Mamdani reflects on his first 100 days as NYC mayor, and what else is left to do
Through his first 100 days as mayor of New York City, Zohran Mamdani has focused on “pothole politics” — a blend of high-level legislative wins and intense focus on everyday essential services that keep the city running. The 34-year-old mayor has delivered on progressive campaign promises, from more funding for child care to new taxes on the ultrawealthy. He views his government as a model for how Democrats can deliver on policies that benefit the working class.In this episode of NPR’s Newsmakers, Mamdani sits down with host Leila Fadel at City Hall to discuss his first 100 days in office, his approach to working with President Trump and the message he believes Democrats should deliver during this year’s midterm elections.NPR's Newsmakers is where you'll find NPR's biggest interviews. We post new episodes as soon as they're available -- any day of the week. Follow or watch the show wherever you get podcasts.Newsmakers relies on supporters who value independent journalism and a free press. Join NPR+ today to support our work and get perks from the podcasts you trust. Go to plus.npr.org.
Paramount's David Ellison makes big promises to theater owners at CinemaCon
He commits to a 45-day theatrical window
Trump tries economic reset as Republicans fret over high gas prices
Trump is set to use a Thursday stop in Las Vegas to tout his tax and immigration bill that includes campaign promises tailored to court hourly and hospitality workers.
Intel launches new Core Series 3 chips for mainstream laptops
The new chips promise all-day battery life and will be adopted by a number of brands throughout 2026.
Battlefield 6 2026 Roadmap Confirmed
Bigger maps and naval warfare are just two of the additions coming to Battlefield 6 in 2026, as its developers have promised to finally, directly address community feedback with a series of major updates.
"No Emulation, No Compromise, No Comparison" - The $250 Neo Geo+ AES Aims To Be A 1:1 Replica Of SNK's Classic Console
"Powered by newly manufactured chips based on the originals"
AMC's Adam Aron backs David Ellison's takeover of Warner Bros. Discovery
AMC Chief Executive Adam Aron said he believes David Ellison will hold to his promise of making 30 films a year from the combined Paramount-Warner Bros. company.
Overwatch's Switch 2 version is currently missing the promised 60 FPS boost, but a fix is coming soon
The long-awaited Nintendo Switch 2 port of Overwatch is missing its 60 FPS boost despite it being at the centre of the announcement.
Overwatch launches on Nintendo Switch 2 with performance issues, Blizzard confirms patch in the works
Overwatch just launched on Nintendo Switch 2 today, but things haven’t gone smoothly. Soon after release, players reported issues with the port – notably with performance. Blizzard promised that the new Nintendo Switch 2 version would run up to 60 frames per second. However, some fans thought that the Nintendo Switch 1 version was accidentally uploaded since the action felt...
What I’ve learned from 25 years of automated science, and what the future holds: an interview with Ross King
We’re excited to launch our new series, where we’ll be speaking with leading researchers to explore the breakthroughs driving AI and the reality of the future promises – to give you an inside perspective on the headlines. Our first interviewee is Ross King, who created the first robot scientist back in 2009. He spoke to […]
Adobe fixes PDF zero-day security bug that hackers have exploited for months
It's not clear how many people were compromised by this hacking campaign, but a security researcher said the hackers were targeting victims since at least November 2025.
Major gift promises to accelerate Princeton University’s leadership in quantum science
The gift from Andy Florance ’86 and Heather Florance will support the Princeton Quantum Initiative and will accelerate the next generation of quantum science research and discovery at the University.
Beware! This "Windows 11 24H2" update download can quietly steal your sensitive data
This Windows 11 24H2 update download could quietly compromise your system and steal sensitive personal data, putting your system's privacy and security at serious risk.
Infantino’s FIFA: Ten years of power, politics, and so-called ethics
Gianni Infantino promised reform, transparency, accountability, and a “new FIFA.” Ten years on, Infantino’s FIFA is instead defined by political proximity, weakened scrutiny, and an increasing alignment with state power at the highest levels.
Bay Area business owner re-dumps mountain of trash on customer driveway after broken promises on payment. Was he right?
This dumpster dispute really dumped things on a whole new level turning one missed payment into a trashy pile of fines, fees and chaos.
Samsung to fix Adaptive Clock glitch in One UI 8.5 update
Adaptive Clock has a glitch on One UI 8.5 devices, and Samsung is working on a fix. The problem has been acknowledged by a community moderator, who promised the addressal with the next Beta software update. It’s already a big day for Samsung users, thanks to One UI 8.5 rollouts. Whether it’s new Beta releases […]
Rockstar Games says hack will have ‘no impact’
Player data isn’t suspected to be compromised.
Illinois Court Hears Final Lawsuit Challenging Marijuana Social Equity Business Licensing Lottery
“We just want a fair shot. We’re not asking for anything special, no special privileges, but what they promised from the very beginning.” By Hannah Meisel, Capitol News Illinois Nearly seven years after Illinois lawmakers approved recreational cannabis legalization, applicants who lost out on coveted business licenses are still battling the state in court, alleging […]
Exclusive | Trump Promises Mass Pardons to Staff Before Leaving Office
In a recent meeting, the president said he would pardon those within 200 feet of the Oval Office, according to people familiar with the remarks.
Steyer wants to end the ‘Trump tax loophole.’ Here's what that means
Tom Steyer’s promise to “reverse the Trump tax loophole” if elected California governor relies on a lot of wishful thinking, political columnist Joe Garofoli writes.
20 years after passing nation-leading health care law, Mass. braces for new challenges
A landmark health coverage law passed 20 years ago gave Massachusetts among the lowest uninsured rates in the country. It inspired the sweeping federal overhaul known as the Affordable Care Act. Now many are wondering whether that period of intense negotiations and compromise offers lessons for today's urgent health care challenges.
CPUID compromise: users report getting malware with HWMonitor and CPU-Z tools
Multiple users are reporting that the CPUID website has been compromised, leading to popular Windows utilities such as CPU-Z and HWMonitor delivering multi-stage, evasive malware.
Mamdani balances governing with delivering on affordability agenda
“I promise you this: If you are a New Yorker, I am your mayor,” Mayor Zohran Mamdani said during his inauguration.
'We Released a Game With Flaws for a Number of Reasons' — Samson Dev Promises Improvements Amid 'Mixed' Reception
The creative director of Samson has promised the team is "committed to the future" of the game despite launching to a 'Mixed' reception on Steam amid complaints about performance, gameplay, optimization, and more.
Trump promised to clamp down on health insurers. His policies are enriching them
In December, Trump said he would summon health insurance execs to the White House. It doesn't seem a meeting ever happened.
Life science real estate developer IQHQ accused of fraud by early investor
Aimco is suing the San Diego-based lab developer for fraud, accusing the company of making false promises to secure an investment that is now worth nothing.
Where's the business exodus from NYC Mamdani critics promised?
New data offers a promising sign for Zohran Mamdani, a democratic socialist who proposed various tax hikes during his New York City mayoral campaign.
A first for Michigan’s $2.4B SOAR business incentive program: New jobs
Companies say they’ve created 1,846 of the 14,559 jobs they originally promised in exchange for Michigan SOAR subsidies. They still have several years to meet their targets.
Eligibility questions spark calls to suspend Minnesota’s $100 million ‘promise’ to small businesses
5 INVESTIGATES found several Minnesota Promise grant recipients appear to be operating miles outside of eligible neighborhoods, and others that may not be operating at all.
What OpenAI’s TBPN deal reveals about branded entertainment’s limits
Brands like OpenAI are building in-house entertainment studios on the promise that great content earns the audiences advertising can’t buy.
We students need mental health counselors not empty promises
'We' are the many Kentucky students drowning in mental health crisis, staring at a counselor’s door that, for all intents and purposes, is locked.
Pinky Cole promises to bring fresh drama to ‘Real Housewives of Atlanta' Season 17
The Slutty Vegan founder tand her 'Housewives' castmate Shamea Morton talked to the AJC about the new season, which debuts Sunday night.
Striking JBS workers to return to Colorado plant on promise of talks
Workers of the world's largest meat company, JBS , agreed to return to work at a beef plant in Greely, Colorado after it agreed to resume negotiations, bringing a three-week picket to an end, their union said in a statement on Saturday.
Business Email Compromises: Current Legal Trends and Key Strategies
Businesses have for years suffered from a sophisticated, targeted cybercrime that exploits trust, human relationships, and our reliance on digital communication: the business email compromise (BEC).
Burkina Faso military leader Traore says ‘forget democracy’
Traore reneged on promises to hold elections and has since scrapped political parties in the country.
The democratisation of business email compromise fraud
This week, Martin tells the story of a crime he encountered and how it shows that the threat landscape is changing.
New Rowhammer attacks give complete control of machines running Nvidia GPUs
Both GDDRHammer and GeForge hammer GPU memory in ways that compromise the CPU.
Cisco Patches 9.8 CVSS IMC and SSM Flaws Allowing Remote System Compromise
Cisco patches two 9.8 CVSS flaws (CVE-2026-20093, CVE-2026-20160), preventing authentication bypass and root access.
Wave of retirements and politics promise spending panel makeover
The House Appropriations Committee is set to undergo a major shake-up following the midterm elections, especially among its Republicans. With four members retiring, two running for Senate and four others in potentially tight reelection contests, nearly a third of the committee’s Republicans may not return in the next Congress. Democrats are looking at a lower […]
Markets rally, oil prices fall as Trump prepares to address nation on Iran war
The White House promised an “important update” on Iran, in what is set to be the president’s first prime-time address since the U.S. and Israeli assault began.
A wild option for cash-strapped homebuyers: fractional ownership
A growing web of fractional-ownership startups say they offer cheaper paths to homeownership. But not everyone is buying into their promises.
Lizzo confesses she lost her virginity after her 2020 Grammys win: ‘I lied about it for a long time’
Lizzo made a promise to herself when she was younger that she wouldn't lose her virginity after she won her first Grammy. In 2020, she won three and made good on her promise.
Big Tech promised AI would disrupt labor — just not like this
Oracle is reportedly laying off thousands of employees, adding to an already long list of tech giants cutting staff while spending hundreds of billions of dollars on AI data centers.
Google's 'Performance Advisor' Steph Curry teases probable new wearable
The video promises "A new relationship with your health" is "coming soon."
Scott Pemberton O Theory added to VanWood entertainment line up
SOUTH LAKE TAHOE, Calif. – VanWood Tahoe, hosted by the Boys & Girls Club of Lake Tahoe in partnership with Kirkwood Mountain Resort and EpicPromise, announced a featured live music experience as part of its inaugural...
Scientists achieve ‘impossible’ solar efficiency in renewables breakthrough
‘Spin-flip’ technique promises to shatter efficiency limits
Jacksonville leaders consider changes to Court Street project after business concerns
A planned construction project on a brick roadway in downtown Jacksonville is moving forward, but city leaders say they are working toward a compromise after co
‘I’m not done’: Jon Maples launches new HD 87 bid, will retool strategy for November race
Maples promised a top-to-bottom campaign review, saying no question is off the table in fine-tuning his General Election strategy.
Why Most Quantum Computers Need to Be Colder Than Space
Quantum computers promise to revolutionize whole industries by outperforming classical computers on complex calculations. They just need to be colder than the coldest natural place in the universe.
Kim Kardashian's New Energy Drink Promises No Jitters. Does It Live Up to the Hype?
Kim Kardashian has released a new "healthy" energy drink called Update, which contains paraxanthine instead of caffeine. We asked experts about paraxanthine vs. caffeine in Update and how it stacks up against traditional energy drinks.
The L.A. Phil premieres Gerald Barry’s wacky ‘Salome’
Following two of the most brilliantly wacky operas of our time from Gerald Barry, the premiere of his 'Salome' promises to out-wacky the others.
‘Promise and Pitfalls’ of AI in health care at center of URI Pharmacy conference
KINGSTON, R.I. — March 27, 2026 — Despite its relative infancy among world-changing technologies in human history—the wheel, the printing press, electricity, the Internet—artificial intelligence has most rapidly become ubiquitous, already adopted by billions of people just a few short years after becoming publicly available. AI has infiltrated virtually all aspects of life, including health […]
Senate funds DHS after Trump’s TSA pay promise
About 50,000 TSA agents are on the verge of missing a second paycheck
CDC's acting chief promises a return to stability in a tumultuous moment
Anker Smart Display 45W USB-C Foldable Charger Drops 30%, Small in Size and Smaller in Price
It's 47% smaller than most chargers, but doesn't compromise on performance.
Congress Passes Small Business Research Reauthorization
If it becomes law, the compromise bill would end a nearly six-month lapse in solicitations and annual funding.
Top business leader demands end to stalemate over City Council's pick for zoning chair
Chicagoland Chamber of Commerce President Jack Lavin said more than 40 development projects have been stalled by City Council's failure to agree on new permanent chair for the powerful Zoning Committee. He wants Mayor Brandon Johnson to forge a compromise to break the stalemate.
Bird‑like robots promise greater flexibility and control than drones
A bird banking in a crosswind doesn't rely on spinning blades. Its wings flex, twist and respond instantly to its environment. Engineers at Rutgers University have taken a major step toward building bird-like ...
Crimson Desert developer apologizes and promises to replace AI-generated art
Pearl Abyss announced a comprehensive audit of its in-game assets and will replace any AI-generated content.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Crimson Desert Dev Breaks Silence Admitting AI Art Was Used
Developers Pearl Abyss apologize for their inclusion and promises to replace its slop with new art.
Thune, GOP blast Dems in DHS standoff as Lankford says they fear ICE over Iran
Sen. James Lankford, R-Okla., accused Senate Democrats of being afraid of ICE than Iran as the DHS shutdown hit its 36th day, as Republicans again offered another compromise deal to reopen.
Unfriendly skies: Ron DeSantis floats privatizing TSA after Elon Musk pay promise
'Why not let the airlines and airports handle it?'
Crimson Desert Dev Promises Patch to Address 'Discomfort Many Players Have Experienced With the Controls,' Apologizes for Awful Keyboard and Mouse Experience
Crimson Desert developer Pearl Abyss has issued a message to players addressing complaints around the game’s controls, which have been widely criticized.
UFC London’s Felipe Franco promises entertainment after teammate Jailton Almeida’s release: ‘They want to see blood’
Felipe Franco battles undefeated Mario Pinto at UFC London
Microsoft Promises Slew of Windows 11 Changes in Response to "Microslop" Criticisms
With every Windows 11 update seemingly introducing a new bug or somehow breaking some core functionality, it seems as though trust in Microsoft and Windows is at an all-time low, with the recent "Microslop" insult popping up in online tech circles as a sort of culmination of the recent spate of issu...
Trump Told Inner Circle Some Mass Deportation Policies Went Too Far
The president is convinced that voters don’t like the term “mass deportation,” and has directed advisers to adopt a new approach on one of his central campaign promises.
Oz Says California’s Not Fighting Health Care Fraud, but Data Shows It’s Part of a Larger Battle
Trump administration officials say the state allows rampant fraud and have promised to investigate, blaming the “Russian, Armenian mafia” in the hospice and home health care industry. But data shows hotbeds of health care fraud throughout the country, with California outperforming most other states in recovering fraud dollars.
Tim Scott says he will run for reelection in 2028, breaking promise that ‘22 would be his last run
U.S. Sen. Tim Scott confirmed he will run for a third term, despite the South Carolinian’s previous pledge to term-limit himself.
Trump said he wanted one of the Texas Senate candidates to drop out. Now he’s missed the deadline
President Donald Trump promised his endorsement was forthcoming in the GOP Texas Senate runoff and said he wanted whoever he didn’t pick to drop out. But now — preoccupied with the Iran war and a doomed voting bill — he’s missed a critical deadline.
Nvidia’s AI-Powered Photorealistic Gaming Technology Roasted As ‘AI Slop’
Nvidia promised its new technology is a “dramatic leap in visual realism,” though gamers voiced fears it will diminish the artistic appearance of video games.
Bethesda promises Nvidia's controversial DLSS 5 AI filters will be "totally optional" for players
Bethesda is committed to "further adjusting the lighting and final effect" of Nvidia's DLSS 5 visuals on Starfield following the controversial AI-tech's reveal.
The scientist who warned that profit, not science, decides which drugs reach patients
In a Genomic Press Interview published in Brain Medicine, Dr. Gabriella Gobbi, Professor of Psychiatry at McGill University, Canada Research Chair (Tier 1) in Therapeutics for Mental Health, and President-Elect of the Collegium Internationale of Neuropsychopharmacology (CINP), delivers a pointed warning: the greatest threat to drug discovery is not scientific failure but a financing system that abandons effective, affordable treatments whenever they cannot promise sufficient returns to investors. Across a career that began in central Italy and moved through Sardinia and Montreal, Dr. Gobbi has generated landmark research linking adolescent cannabis exposure to depression, identified novel melatonin receptor mechanisms in sleep and pain, and launched psychedelic neuroscience before it became fashionable. The interview reveals a scientist whose best questions have always begun at the bedside, and whose most urgent fears concern the structures that stand between discovery and patients.
Plagued by early deficits, Wild turn page to meet Blackhawks
A three-game winless streak has done little to compromise the Minnesota Wild's solid playoff positioning.
Nvidia's DLSS 5 promises to bring you out the other side of the uncanny valley
GTC: The latest generation of Nvidia’s AI image enhancer brings characters to life
Burger King splashed on Oscars ads to admit mistakes, promise changes
Burger King dazzled Oscars viewers with a self-deprecating ad campaign, announcing it had fired its "King" mascot and revamped the Whopper.
Robotics firm Intuitive Surgical says cyberattack compromised business, customer data
The company said an intruder accessed employee information, customer contact details and other records.
Hay fever: The new wave of effective cures for seasonal allergies
Is it possible to train the body to resist seasonal allergies? That’s the hope promised by a new line of immunotherapy.
'Sinners' and 'One Battle After Another' poised for an all-Warner Bros. showdown at Academy Awards
The Academy Awards promises a thrilling showdown between Paul Thomas Anderson’s “One Battle After Another” and Ryan Coogler’s “Sinners,” with both directors vying for their first Oscar.
Matt Hart: Why conservatives must defend the rule of law
When the law bends for the powerful or breaks against the disfavored, the justice system — and our faith in it — is compromised.
Is stem cell therapy the next frontier to treat diabetes? Louisiana experts aren't convinced.
Personalized therapies for diabetes, while showing promise in international studies, is met with healthy skepticism from Louisiana experts. "Maybe in 20 years," a doctor at LSU Health says. Here's what to know now.
FSG defends its record in Pittsburgh as sale of Penguins nears
After members of a city agency on Thursday said Fenway Sports Group had failed to deliver on promises to Pittsburgh and accused the organization of “profiteering,” FSG...
Gavin Newsom promised over one hundred mental health projects — many are still abandoned
The promise and peril of health care AI
AI isn't lifting all boats equally in health care. At times, it might be making things worse.
Sen. Welch: Trump administration promises on gas prices are ‘wishful thinking’ amid war with Iran
Meta’s Moltbook gamble looks a lot like bubble behavior
Meta, the company that changed its entire brand identity five years ago on the promise of a technology it turned out no one wanted, just spent an undisclosed sum to acquire Moltbook, a “social network” built for “AI agents.”
Packers Free Agency: Contract Details for Jonathan Ford
Jonathan Ford is coming back in 2026, but his contract doesn’t promise him a roster spot.
‘LOL THAT’S IT?’: politics aside, the UFC’s White House card isn’t worth the price of admission
Donald Trump promised that June’s event would bring us some of the greatest fights in history. The truth appears to be rather different
"I was fighting to survive": Patients still struggle with preauthorization despite promise of reform
Trump to visit Ohio and Kentucky to discuss the war's impact on the economy
This trip marks the first time this primary cycle that Trump has sought to keep promises to punish members of his own party who oppose him on key issues.