SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " ting " 48,046 found 🔀 AI-powered Shuffle
Memorial Health celebrates staff with trunk-or-treat
Memorial Health went all out for its annual trunk-or-treat event, celebrating team members and their families.
Data center boom sparks massive power line fights hundreds of miles away
In Cat Kemmerling’s dream, she and her husband Rob are sitting in their pickup truck on a cliff on their West Virginia farm, overlooking the Shenandoah River. The truck is falling backwards over the edge, into the abyss below.
Is having urine the color of Mountain Dew normal?
A Trump administration doctor says neon yellow urine is normal because of diets consisting entirely of meat and fermented foods. Here’s what experts say
Astros should stay away from these 2 free agent outfielders
Astros shouldn't be interested in these two outfielders.
Googlebook is getting AAC Bluetooth audio and key fixes for Cast My Apps
As we talked about earlier this week, every brand-new platform goes through growing pains right out of the gate, and Googlebook OS is no exception. While we've already seen Google step up to...
How Braves should handle $42 million Jurickson Profar situation
This could be one solution for the Braves.
Packers Lose Defensive Captain Just Before Massive Showdown With Lions
Green Bay Packers defensive captain Zaire Franklin has been ruled out against the Detroit Lions, leaving Green Bay without both starting linebackers.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
California election officials frustrated, rattled by DOJ demand to sequester 'noncitizen' ballots
The administration has insisted that immigrants voting is a major problem nationwide, when in fact it is quite rare, as even its own investigations have shown.
Google's next TV gadget may do much more than stream
A reported hardware overhaul could bring Gemini further into the living room.
Florida political leaders mourn after shooting at FAMU homecoming
Florida politicians express grief after a shooting near FAMU homecoming festivities injured multiple people.
Mystery Ohio news site boosting Ramaswamy's Amy Acton ad tied to California GOP non-profit
As Ohio Republican gubernatorial candidate Vivek Ramaswamy came under fire for releasing an attack ad featuring his Democratic competitor Amy Acton's estranged mother, a mysterious news site was runni...
Stateliner Pride on Display: Phillipsburg Band and Alumni Unite at Halftime
Phillipsburg’s Stateliner band and alumni joined for a halftime performance celebrating school tradition, pride and community at Friday’s football game.
Evaluating DJ Herz After Bouncing Back from Injury with Nationals
After making his first MLB appearance in nearly two years, what should the Washington Nationals expect from DJ Herz in his third season with the organization?
Micron Just Revealed a New Business Strategy. That Change Makes It a Screaming Buy.
Micron is changing more toward contracts, rather than letting the open market dictate pricing.
After Fighting in Gaza and Battling PTSD, Shahar Varon Seeks a Voice In Israel's Mental Health Future
Soldiers and others suffering from post-traumatic stress disorder […]
October 7 should have changed Israeli politics, yet we are voting for the same leaders
Israel deserves more than another election between yesterday’s failures. It deserves a new beginning.
NFL Trade Deadline Could Dramatically Change The AFC South Landscape
With top stars from the Titans, Colts, and Jaguars hitting the trade block, Houston’s rivals could strip their rosters of veteran talent to fuel a mid-season rebuild.
NC business co-owner kills man ‘acting irrationally’ outside Zumba class, police say
A man “acting irrationally” toward patrons of a Zumba fitness class was fatally shot when he turned his attention to an armed business co-owner at the scene, according to investigators in western North Carolina. The confrontation occ…
Arch Manning has another viral moment with ESPN's Holly Rowe
The Texas quarterback was happy to see Rowe on the sidelines.
Instacart Stock What Health Benefits Deal And $5 Million Settlement Mean
Instacart parent Maplebear has agreed to a US$5,000,000 settlement with U.S. authorities over past PERM hiring practices and has been selected by True Rx Health Strategists to power an employer funded healthy food benefit through Instacart Health Fresh Funds starting in 2027. The True Rx program positions Instacart within pharmacy benefit design and ties employer spend directly to clinically supervised food choices. The settlement adds compliance obligations, policy changes and monitoring...
Silicon Valley software engineer pay ranked against other US cities
Bay Area software engineers retain a 53% pay premium after adjusting for local prices, Levels.fyi found. Taxes aren't included.
LETTER TO THE EDITOR: Misleading political mailer is a smear campaign
The recent misleading smear mailer by the opponents of Denise Krause in the Oregon Senate campaign is the most disgusting exhibit of money and indecency used to capture uninformed voters’ […]
Nuthatches are rude: Ornithological observations from a recliner
I don’t know what age you’re supposed to start sitting in a recliner and looking out the living room window at the bird feeder, but I sure do like doing
Culture House Wants to Turn Creator Connections Into Lasting Businesses
Culture House connects creators directly with investors and operators, helping turn cultural influence into sustainable businesses.
Explore Health, Oregon’s new health insurance marketplace, is ready for business
This fall, Oregonians who buy health insurance directly instead of getting it through their employer will need to use a new website, the Explore Health marketplace.
Explore Health, Oregon’s new health insurance marketplace, is ready for business
This fall, Oregonians who buy health insurance directly instead of getting it through their employer will need to use a new website, the Explore Health marketplace.
Clemson HC Dabo Swinney Waving White Flag on Season
Following a humbling loss to Virginia Tech, Dabo Swinney is recalibrating expectations as the Tigers abandon playoff dreams and fight to salvage a disappointing, sub-par season.
'All INdiana Politics': Engling, Ballard clash over restoring credibility to Indiana Secretary of State Office
INDIANAPOLIS — On Sunday’s edition of “All INdiana Politics,” Government Reporter Garrett Bergquist sat down with two candidates who are running for secretary of state, Republican Max Engling and independent Greg Ballard. Both candidates outlined contrasting approaches to restore credibility to an office plagued by controversy under outgoing Secretary Diego Morales. They both presented different […]
Physician Mental Health and Health System Privacy: Why Doctors Avoid Their Own EHR
In most organizations the default access model was built for patient care, not for protecting colleagues. A nurse on another unit, a resident who rotated with them, a department administrator: any of them may technically be able to open the record, even when policy says they should not.
Business co-owner kills man ‘acting irrationally’ outside Zumba class, NC police say
The business co-owner was carrying a firearm, Spindale police say.
Cutting ‘red tape’ is nothing but a red herring
Blaming a moribund economy on too many rules is a hackneyed neoliberal trope – UK plc needs smarter regulation, not less regulation
Tickets on sale now for 49 Winchester's Charlottesville show next year
49 Winchester, a homegrown Virginia country rock band, is the first band announced for Ting Pavilion's 2027 lineup. Tickets are on sale now.
A last-minute voter guide to all 14 propositions on the California ballot
Californians are voting on 14 ballot measures, including propositions on taxes, voting, healthcare, housing and the environment. It's a lot to take in, but we're here to help.
She voted for Trump every time. Then came cancer and the bills
Cindy Banda faces mounting medical bills after battling breast cancer. Despite the single mother's positive outlook, the financial strain combined with the high cost of living is overwhelming. And it's
She voted for Trump every time. Then came cancer and the bills
Cindy Banda faces mounting medical bills after battling breast cancer.
She voted for Trump every time. Then came cancer and the bills
Cindy Banda faces mounting medical bills after battling breast cancer.
Iain Armitage says “Young Sheldon” cast drove each other ‘crazy’ while shooting season 3 opening credits
The ensemble would ‘drive each other nuts.’
Iain Armitage says “Young Sheldon” cast drove each other ‘crazy’ while shooting season 3 opening credits
The ensemble would ‘drive each other nuts.’
Jodi's Journal: The end of an on-air era
Congratulations to a local broadcasting legend as Bill Zortman logs off the air later this week after a 60-year career.
Patriots rooting guide for NFL Week 7
Rooting information, kickoff times, TV schedule and more for NFL Week 7.
Gyökeres May Not Be Scoring, But He’s Helping Arsenal Win
Viktor Gyökeres is still waiting for his first Premier League goal of the season, and for a striker of his reputation, that’s always going to attract attention.But are we becoming too focused on wh...
The top 25 modern golf courses in Canada, ranked
Our ranking of top modern Canadian courses returns, with Nos. 1 and 2 sitting side by side.
CBS News political experts weigh in on Texas Senate race halfway through early voting
The latest CBS News poll showed Talarico leading 51% to 49%, well within the margin for error.
New York Giants' Never-Ending Nightmare Might Get Even Worse
Things just keep getting worse for the New York Giants.
Powers Health Community Hospital Achieves Statewide Milestone in Treating Heart Valve Conditions
Powers Health Community Hospital has successfully performed Indiana’s first procedure using the SAPIEN M3™ transcatheter mitral valve replacement (TMVR) system, a minimally invasive treatment for …
Some iPhone Duo displays are cracking, seemingly all in the same way
Following the iPhone Duo launch on Friday, a number of owners are reporting that their inner screens have cracked and...
Antarctica’s “Doomsday Glacier” Could Raise Sea Levels Twice As Much as Scientists Feared
Even without further warming, Thwaites Glacier could contribute twice as much to sea level rise by 2100 as previously estimated, according to a revised ice sheet model. Thwaites Glacier in West Antarctica has been retreating and thinning rapidly, while satellites show substantial acceleration in its ice flow. Traditional ice sheet models have depicted slower movement,
4 Android phone features you should never disable when using Android Auto
Some settings are better left untouched
Best AI Tools for Small Business Marketing (2026): CapCut Featured for Creating Professional Video and Visual Content by Expert Consumers
Expert Consumers has recognized CapCut in its 2026 coverage of the best AI tools for small business marketing, highlighting the platform's collection of AI-powered features for creating and editing video, images, audio, and other visual content. The recognition reflects growing interest in tools that support practical marketing activities, including campaign development, promotional content production, and adapting creative assets for different digital channels.
BREAKING: Courtois out against Barcelona
Real Madrid have announced that goalkeeper Thibaut Courtois will not play against FC Barcelona tonight. Per Realmadrid.comCourtois is a last-minute drop due to a flu process for tonight’s match between Real Madrid and Barcelona, corresponding to the tenth round of the League. Illia Voloshyn enters the squad list in his place. This is devastating news […]
Political attack ads are ugly. We don’t have to be
Political division is testing our character. It is time to trade the anger for kindness and respect.
Health centers brace for new Med-QUEST rules
Starting Jan. 1, most adults enrolled in the government’s Medicaid program will have to show they work, volunteer or go to school part-time at least 80 hours in a month to qualify for healthcare under Med-QUEST, Hawaii’s Medicaid program.
Latino businesses still fearful amid ICE sightings 8 months after Operation Metro Surge
A handful of new Latino eateries have opened on Payne Avenue, as others have slashed hours or remain closed certain weekdays.
Student-loan borrowers facing higher bills are slashing their budgets
From cutting back on groceries to delaying starting a family, student-loan borrowers describe the changes they're making to afford higher payments.
Islanders Gameday News: Starting in Dallas; Hellebuyck moves next door
The Islanders have touched down in Dallas for a Sunday night encounter, where Pete DeBoer will be the story as he faces his most recent former team. The Stars are in their 1980s Capitals era (or more generously, 1980s Flyers), perennially fielding really good teams but finding different reasons and divine interventions to prevent their […]
With 52 Businesses Waiting, Charles County Weighs Expanding LaunchPad
LA PLATA, Md. — For dozens of Charles County entrepreneurs, getting a business off the ground includes another hurdle: waiting for a spot in a county training program. Economic development officials told the Charles County commissioners on Tuesday, Oct. 20, that 52 businesses remained on the waiting list for LaunchPad, a pilot program designed to […]
Early voting underway in upstate New York
Early voting continues through Nov. 1 and Election Day is Nov. 3.
Hochul, Blakeman hit the campaign trail as early voting begins
Both Kathy Hochul and Bruce Blakeman’s campaigns are escalating their attacks over affordability and the governor's record.
Why partisan politics may be changing people's accents
With the midterms fast approaching, communicating just the right message has been top of mind on all sides of the political aisle
KIII 3 News
KIII 3NEWS is the ABC affiliate in Corpus Christi, Texas, operating to serve, inform and improve communities in the Coastal Bend. The station began broadcasting in South Texas on May 4, 1964. Today, KIII 3NEWS dominates one of the fastest-growing markets in Texas. The station’s service to the community and commitment to local news and weather coverage has consistently made it the Coastal Bend's news leader for decades.
“We Have No Business up There” – Gattuso Insists Lazio Are Targeting 40 Points
Gennaro Gattuso urges Lazio to keep their feet on the ground and focus on modest objectives despite leading the Serie A table.Lazio Overcome Parma TestThe Biancocelesti raised their tally to 22 from a...
The Long Life of the ‘Snacking Occasion’
As eating habits shift, the food industry is promoting any opportunity to nibble.
In Deep Red Kansas, a Trump Loyalist Fights to Defend a Senate Seat
Senator Roger Marshall was slow to recognize the steep challenge he faced in his solidly conservative state. Now he is confronting dissent among voters with deep economic worries.
Independent candidates sense a moment in the West. Democrats are hoping they're right
As they look to win the Senate, Democrats are hoping that independent candidates in Nebraska and Montana can help them topple Republicans in a part of the country where their own brand is hurting.
Juventus is limiting one of their best players
Kerim Alajbegovic was expected to receive considerably more playing time following Kenan Yildiz’s injury, which is set to keep the attacker out of action until the end of 2026. However, things have ...
Why crafting is good for your brain, according to science
Knitters and other crafters say busy hands quiet their minds. But experts say there are also benefits for cognition.
3 mental health habits that may help your blood pressure
Exercising and eating a healthy diet are important. But your mindset may benefit your health, too.
Liverpool committing to Barcelona model, massive change for club
Liverpool are committing to the Barcelona model. It's a massive change for the club - but will it pay off?Liverpool have a transfer strategy under Jurgen Klopp and it was a wildly successful one. They...
That Girl Boina: How employee theft is hurting small businesses in Africa
That Girl Boina's post about why she had closed her beauty parlour struck a nerve with other small business owners.
Bayern bosses offer differing assessments of Lennart Karl’s development
Bayern Munich honorary president and supervisory board member Uli Hoeneß has spoken strongly about Lennart Karl, insisting that the highly rated youngster is still far from being a superstar. In an i...
Reducing drug harm in NC mountain counties
Needle exchanges, disease testing, providing Narcan and other harm reduction efforts navigate complexities of Western NC communities.
Building a rural business empire on the back of coffee beans
Lewie Graham runs a cafe, restaurant and coffee bean roasting business in Kirkcudbright.
Where to watch Kansas vs. Duke basketball: Channel, live stream, time, TV schedule for men's exhibition game
It's a preseason matchup of blue bloods as Duke visits Kansas on Sunday. Here's when and where to tune in.
What business thinks of the politicians and parties
Business leaders are hard to impress this election. In the Herald's annual “Mood of the Boardroom” survey, they give poor or middling marks to almost the whole political class, including the two former business executives running the Government's economic policy, and several ratings are among the wo
Predicting the US LBM Coaches Poll top 25 entering Week 9
The US LBM Coaches Poll is sure to see some shakeup on Sunday after another day filled with upsets in Week 8.
Union to Dedicate Historic Marker Commemorating Battle of Connecticut Farms as Part of America's 250th Celebrations
Union – The Township of Union Planning Committee for the 250th Anniversary of the United States, in partnership with the Union Township Historical Society, invites residents and history enthusiasts...
VT Science Corner: Expanding eating disorder care to rural areas
The great Taylor Swift proclaimed “I’m the problem, it’s me” in her 2022 song, "Anti-Hero." This lyric reflects something many people can recognize: the belief that something is fundamentally wrong
Everything’s the Best: Reason to Believe
With more than 10 matches in all competitions played, are we finally starting to see the promise of Isak and Wirtz?
Clifton ‘Jackie’ Jackson: A towering gentleman of the bass
Clifton ‘Jackie’ Jackson embodies Robert Farris Thompson’s classic concept of the ‘aesthetic of the cool’, also referred to by the ancient Yoruba concept of itutu. He was the elegant bassist whose lines were as refined as his demeanour. Calling him the ‘Rolls-Royce of Reggae Bassists’ isn’t to suggest he didn’t roll with some of the deepest, lilting roots grooves like others. He added an unmatched touch, poise and musical sophistication to the bottom end while retaining every bit of the heavy, syncopated pulse required for authentic Jamaican music.
Clemson HC Dabo Swinney Puts Coach on Notice, Offense 'Disturbing'
After a deflating loss to Virginia Tech, Swinney confronts roster gaps and coaching failures as the Tigers' playoff hopes vanish and the offense faces a critical crossroads.
Aaron Ashby approaches history with latest dominant performance for Brewers
The lefty reliever has been the Brewers' best pitcher this postseason.
As the US and China form AI blocs, countries are increasingly torn between them
With the two leading AI powers, the United States and China, forming their own AI blocs, other countries are maneuvering to harness the strengths of both groupings without alienating either and risking losing out.
Latest Karl-Anthony Towns Update is Good News For Warriors
The Golden State Warriors need to find creative routes to improve the roster with Stephen Curry starting to hit the late chapters of his career. NBA pundits have started to question whether the New York Knicks will retain Karl-Anthony Towns. Recent reports have shown Towns and the Knicks far apart on the extension talks of […] The post Latest Karl-Anthony Towns Update is Good News For Warriors appeared first on HEAVY.
More than barbecue: Lexington festival brings big business and a community together after devastating fire
Cougars picture-perfect Homecoming scene goes sideways
When the meeting between Washington State and Boise State was announced, it was immediately circled by many to be one of the better games of the revamped Pac-12 slate. Especially in the timeslot it was put in. A late October matchup at 3pm in Pullman. College football is arguably at its peak around this time […]
Tulsa Health Department hosts 10th annual North Tulsa Community Baby Shower
The Tulsa Health Department hosted its 10th annual North Tulsa Community Baby Shower on Saturday, connecting expecting parents and families with young children
Michigan’s Kyle Whittingham Pinpoints 3 Costly Failures Behind Indiana Loss
The Michigan Wolverines had enough defensive resistance to push Indiana into overtime, but their offense never supplied the breakthrough needed to finish the job. Following the 13-6 defeat, coach Kyle Whittingham offered a straightforward explanation of where the game slipped away. His assessment centered on three problems that Michigan could not overcome.Whittingham pointed to the […] The post Michigan’s Kyle Whittingham Pinpoints 3 Costly Failures Behind Indiana Loss appeared first on HEAVY.
Colts make roster moves ahead of road matchup vs. Minnesota
The Colts are elevating a familiar face at linebacker to their active roster ahead of Sunday’s road game.
Miami's Israeli gold rush: Michelin-starred restaurants, billion-dollar deals and booming businesses
From a Michelin-starred kosher restaurant and Eyal Shani's growing presence to massive real estate deals, Israeli businesses are flourishing in Miami; but soaring costs, bureaucracy and distance from family are testing the American dream
Lions vs. Packers: 3 Best Player Prop Bets for Sunday's Showdown
The Lions and Packers bring explosive offenses into Sunday's divisional showdown. I'm 10–8 on the season and targeting three player props to cash at Ford Field.
Jordan Mason is back, and the rest of the NFC should be worried
The Minnesota Vikings are getting a major offensive weapon back as running back Jordan Mason returns from injured reserve. With a crucial matchup against the Indianapolis Colts approaching, Mason's return could give Minnesota the boost it needs to keep its unbeaten streak alive.
Houston Rockets jersey history No. 35 - Larry Spriggs (1981-82)
During his time suiting up for the Rockets, Spriggs wore only jersey No. 35 and put up 3.5 points, 1.5 rebounds, 1.0 assists per game.
Simply unbelievable! Neymar sent off under the 'Vini Jr law'
Neymar's Saturday night (24th) borders on the unbelievable.After halftime in Santos' 1–0 loss to Bahia at Vila Belmiro, the star No. 10 CONTINUED taunting Rodrigo Nestor before play resumed at the s...
Alabama Renaissance Faire celebrates its 40th year
FLORENCE — Alabama’s Renaissance Faire is celebrating its 40th year this weekend at “The Fountain on the Green,” which is also known as Wilson Park. The event features costumed performers
Ravens starting QB to miss Sunday’s game against Bengals
The Cincinnati Bengals will play the Baltimore Ravens without going against the Ravens’ starting quarterback on Sunday.
Malta Drive-In added to NY historic business registry as it closes for season
With Halloween approaching, the Malta Drive-In is getting into the holiday spirit while also preparing to close for the season.The drive-in is being added to th
Bell County early voting reaches 42,964 ballots through Saturday
Bell County voters cast 7,523 ballots on Saturday, Oct. 24, pushing the cumulative early voting turnout to 42,964 through the first six days of voting.