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Glyphosate: A story of science, risk, and nuance
In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
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Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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GLP-1 Weight-Loss Drugs Prove Effective Across Diverse Patient Groups
By Deanna Neff HealthDay ReporterFRIDAY, March 6, 2026 (HealthDay News) — As the popularity of medications like Ozempic and Trulicity for losing weight continues to soar, folks may wonder: "Will they work for me?" Researchers at Johns Hopkins Bloomberg School of Public Health sought to shed light on ...
'No issues' with Hearn after Aspinall deal
Dana White says he has "no issues" with Eddie Hearn after UFC heavyweight champion Tom Aspinall signed for the boxing promotor's new talent agency.
UFC champion Aspinall signs for Hearn's new talent agency
UFC heavyweight champion Tom Aspinall signs for boxing promoter Eddie Hearn's new agency.
UFC champ Aspinall inks business deal with boxing promoter Hearn
UFC heavyweight champion Tom Aspinall has signed a "commercial and advisory" deal with Eddie Hearn's newly established Matchroom Talent Agency.
Most Patients Keep Weight Off With Fewer GLP-1 Shots, Study Finds
In a recent review, a small group of patients received the injections less frequently but still maintained weight loss and health benefits.
‘Enough’ with blame and shame: The science behind obesity and GLP-1s
In a new book, Yale endocrinologist Ania Jastreboff teams up with Oprah Winfrey to transform how we think about health, weight, and obesity.
Virginia Science Olympiad at UMW Celebrates STEM Learning Across the Commonwealth
Eliora Teshome held her breath while her balsawood bridge was put to the test. The Lake Braddock Secondary School student from Burke, Virginia, had worked for months – in her school’s testing lab, during library hours and late at night – with fellow eighth-grader Rebecca Huang to build the miniature model into a winning weight-bearing […]
UFC champion gives Max Holloway vs. Charles Oliveira 2 prediction
The UFC's symbolic BMF title bouts pit fighters known to put it all on the line each time out against each other for fan-friendly scraps that are nearly impossible to disappoint. Former featherweight champion Max Holloway looks to defend the BMF belt for a second time in the UFC 326 main event ...
War with Iran means higher gas prices. How is that affecting your small business?
Rising oil prices tied to the conflict in the Middle East could add another strain for US small businesses already struggling under the weight of stubborn inflation and President Donald Trump’s hefty tariffs.
Nepal’s gen-Z election: can popular former rapper Balen topple a veteran political heavyweight?
With 46% of Nepal’s population under the age of 24, the election will be a test of whether their hopes and frustrations are being taken seriously
BBC Audio | Business Daily | The worldwide weight-loss revolution
Drugs like Ozempic, Wegovy, Mounjaro and Zepbound are reshaping global obesity treatment
Hims expansion may not come in time for risky GLP-1 business
Telehealth company Hims & Hers Health , known for its weight-loss drug business, is promising it can diversify away from its reliance on compounded GLP-1 sales in the U.S., but that may not happen soon enough for investors who are growing impatient.
Science of Fitting In: Do Best Friends or Popular Peers Shape Teen Behavior?
As kids enter adolescence, peer influence splits in two—often in ways adults miss. Following 543 middle schoolers for one semester, researchers found that best friends shape teens’ inner lives, from emotional struggles to academic challenges, while popular peers influence public, status-driven behaviors like social media use and weight concerns.
Science of fitting in: Do best friends or popular peers shape teen behavior?
As kids enter adolescence, peer influence splits in two—often in ways adults miss. Following 543 middle schoolers for one semester, researchers found that best friends shape teens’ inner lives, from emotional struggles to academic challenges, while popular peers influence public, status-driven behaviors like social media use and weight concerns. Far from being easily swayed, adolescents navigate peer influence strategically—an insight frequently overlooked by parents and educators.
GLP-1s may increase risk of osteoporosis and gout, new research finds
A large analysis suggests the popular weight loss drugs may carry an increased risk to bone health.
Matches To Make After UFC Mexico City
UFC Mexico City went down last night (Sat., Feb. 28, 2026) inside Arena CDMX in Mexico City, Mexico, which saw Lone’er Kavanagh defeat Brandon Moreno via unanimous decision in a pivotal men’s Flyweight bout. In the co-main event of the evening, David Martinez secured his tenth straight win, defeating Marlon Vera via unanimous decision, while […]
BBC Audio | Business Daily | Weight-loss drugs. Who pays?
Weight-loss drugs have transformed lives but unleashed a debate about should pay for them
'Legendary moment' - Kavanagh upsets ex-champion Moreno
Britain's Lone'er Kavanagh claims the biggest win of his career as he upsets former UFC flyweight champion Brandon Moreno in Mexico City.
Alex Pereira shockingly vacates UFC title to spark heavyweight rumours
Periera reclaimed his light heavyweight title from Magomed Ankalaev at UFC 320 but the Brazilian has now vacated the belt
Scientists discover diet that tricks the body into burning fat without exercise
Researchers found that cutting two amino acids common in animal protein—methionine and cysteine—made mice burn significantly more energy. The boost in heat production was nearly as powerful as constant exposure to cold temperatures. The mice didn’t eat less or exercise more; they simply generated more heat in their beige fat. The discovery hints that diet alone might activate the body’s calorie-burning machinery.
My doctor keeps focusing on my weight. What other health metrics matter more?
Our Real Talk with a Doc columnist explains how to push back if your doctor's obsessed with weight loss. And what other health metrics matter more instead.
Novo Nordisk to halve US list price of Wegovy from 2027
Novo Nordisk will slash U.S. list prices of its blockbuster diabetes and weight-loss drugs Ozempic and Wegovy by up to 50% starting next year to $675 a month, the Danish
Tales of Berseria Remastered Review
In Tales of Berseria, the story and the characters do almost all the lifting. It's a good thing it's so amazing, because there sure is a lot of weight on its
How Leptin Became the Sexiest Thing in Science (Again)
Thirty years after its discovery, scientists are eyeing leptin with renewed interest, for everything from weight loss drug cocktails to novel treatments for rare diseases and anorexia.
Teetering US tech trade puts anchor on market as Nvidia test looms
The technology stock trade has stumbled out of the starting block in 2026, stemming from pressure from artificial intelligence disruption fears and the allure of groups that have lagged, but the broader market may struggle to make substantial gains without the heavyweight sector's help.
Two of NBA's heavyweights finally meet as Pistons host Thunder
The Oklahoma City Thunder and the Detroit Pistons have led their respective conferences most of the season, but they haven't measured up against each other. That changes on Wednesday night when the defending champions visit the Motor City.
Healthy Returns: What’s next for Novo Nordisk’s next-generation obesity drug CagriSema after trial miss
The Danish drugmaker released late-stage data showing that the upcoming injection CagriSema failed to match the weight loss of Eli Lilly’s Zepbound.
Fat or Skinny Fat: Both Can Harm Your Health | Join the Anti-Obesity Health Base: Outsmart the Obesity Threat Together
Hong Kong is a world-renowned food paradise, offering everything from local snacks like fish balls and egg waffles to Michelin-starred culinary experiences. However, maintaining a healthy weight amidst fast-paced lifestyles, high pressure, and even genetic factors has become a relentless battle. Excessive fat accumulation poses significant health risks, and even those with a seemingly slender physique can fall into the trap of obesity. Today, obesity is no longer just a cosmetic concern; it is c
Sean Strickland
Former middleweight champion Sean Strickland is eyeing another shot at the 185-pound championship fresh off his UFC Houston TKO win over Anthony Hernandez. Strickland's former training partner turned bitter rival Khamzat Chimaev holds the middleweight crown but is considering moving up to the light ...
Shields beats Crews-Dezurn to retain title
Claressa Shields defends her undisputed heavyweight crown by beating fellow American Franchon Crews-Dezurn by unanimous points decision in Detroit.
Johnny Knoxville's silly and sincere messages for the folks back home
'Jackass' star Johnny Knoxville is raising money for South-Doyle High School's new weight room. Find out how he's giving back to his hometown.
Garcia beats Barrios to claim WBC welterweight title
Ryan Garcia secures his first major title with a dominant unanimous decision victory over Mario Barrios in Las Vegas to become the new WBC welterweight champion.
Ryan Garcia routs Mario Barrios to take WBC welterweight title
And the new! Ryan Garcia has won his first world title as a professional.
Ryan Garcia vs. Mario Barrios full fight video highlights
Ryan Garcia wins WBC welterweight title against Mario Barrios
Wells Fargo Raises Outlook on Cardinal Health (CAH), Cites Broad Business Strength
Cardinal Health, Inc. (NYSE:CAH) is included among the 16 Best Dividend Stocks with Rising Payouts. On February 10, Wells Fargo raised its price recommendation on Cardinal Health, Inc. (NYSE:CAH) to $256 from $237. The firm reiterated its Overweight rating on the stock. The decision followed a strong Q2 performance, which led the firm to lift […]
Simulations shed light on how snowman-shaped body in Kuiper belt may have formed
Research adds weight to theory Arrokoth’s two lobes produced by gravitational collapse – and reveals process
Ulster heavyweights renew rivalry as Harte returns to Derry
It's round four of the National Football League and the runners and riders in all four divisions are becoming ever clearer.
Breaking Down Kelly Clarkson's Health Issues
Plus, how her diagnosis led to her weight loss and more.
Morgan Stanley Maintains Equal Weight on Phibro Animal Health Corporation (PAHC), Cites Margin Expansion
Phibro Animal Health Corporation (NASDAQ:PAHC) is among the 7 Cheap Pharmaceutical Stocks to Buy According to Hedge Funds. The seventh stock on our list of cheap pharmaceutical stocks is Phibro Animal Health Corporation (NASDAQ:PAHC). TheFly reported on February 6 that Morgan Stanley increased its price target on PAHC to $49 from $45 and maintained an Equal Weight rating. […]
Morgan Stanley raises its price target on Sphere Entertainment Co. (SPHR) to $135 and maintains an overweight rating
Sphere Entertainment Co. (NYSE:SPHR) is among the 11 Best Entertainment Stocks to Buy According to Wall Street. On February 13, 2026, Morgan Stanley raised its price target on Sphere Entertainment Co. (NYSE:SPHR) to $135 from $105 and maintained an Overweight rating, citing stronger-than-expected results from The Wizard of Oz. The firm said the performance lifts […]
Ethan Hawke Says “I’m All For” Fight Against Fascism
‘The Weight’ star at a Berlinale presser discussed the role of film artists in battling against the rise of the far right in Europe and the U.S.
General Mills Wants to Win Health-Conscious Shoppers; Cut in Outlook Slams Stock
General Mills is getting aboard the GLP-1 train as the company navigates shaky consumer sentiment. Chief Executive Jeff Harmening told investors Tuesday that the weight-loss drugs will have a lasting influence on the business of food, nudging some consumers toward smaller portions, and more nutrien
The Science of "The Why": Why Your Biology Fights Weight Loss (and How to Win)
Read Wesley’s inspiring 200lb weight loss story and learn why Dr. Maldonado calls obesity a chronic disease that requires more than just willpower.
What Happens to Your Body When You Drink Water First Thing in the Morning
Drinking water in the morning can help improve alertness and weight management, as well as heart, metabolic, kidney, and skin health.
The State of Video Gaming in 2026 by Matthew Ball / Epyllion
In 2025, video gaming had more revenue and cultural weight than ever. Why, then, is growth (and even revenue ) so elusive? Why are player counts retreating across much of the developed world? And why is the very idea of the “video game industry” so flawed?
Al Roker Drops Into 1 of His Favorite Bodyweight Exercises On Air
Wall squats are an isometric exercise that Al incorporates regularly into his at-home strength routine — and they have some impressive health benefits.
Wardley vs. Dubois Title Fight Set For May 9
Fabio Wardley is set to defend his WBO Heavyweight title for the first time against Daniel Dubois on May 9, 2026 inside Co-op Live in Manchester, England in a bout between two hard-hitting, knockout producing British big men. Wardley (20-0-1) won the interim strap in Oct. 2025 with a technical knockout (TKO) win over Joseph […]
Intermittent fasting no better than typical weight loss diets, study finds
Researchers say limited eating approaches such as 5:2 diet not a ‘miracle solution’ amid surge in their popularity
Intermittent fasting probably doesn’t help with weight loss
Intermittent fasting appears to be no better than doing nothing when it comes to helping people who are overweight or have obesity lose weight
Oral bacteria may signal metabolic health and even contribute to obesity
It turns out your mouth may know more about your metabolism than your bathroom scale. New research shows that people with obesity host a distinct oral microbiome compared to individuals at a healthy weight. Rather than zeroing in on the gut microbiome, the study turns our attention to the mouth as a potential biological signal of metabolic health. It’s a shift that could challenge long-held assumptions about where obesity-related biomarkers can be measured.
Hedge funds bet big against Hims & Hers Health before Wegovy showdown, Hazeltree data shows
Hedge fund bets against Hims & Hers Health hit their highest in at least a year in January, just before the online telehealth firm clashed with Novo Nordisk over its cut-price weight-loss pill, according to data shared with Reuters by Hazeltree.
Berlinale Immediately Gets Heated at Jury Presser as President Wim Wenders Asserts “We Have to Stay Out of Politics”
"We are the counterweight of politics, the opposite of politics, we have to do the work of people — not the work of politicians," said the legendary filmmaker at the first Berlin Film Fest press conference.
Why Slovenia, a nation of 2 million, is one of sport’s biggest overperformers
From the ski jumping sensations at the Winter Olympics to Luka Dončić, Slovenia is punching above its weight with sports stars.
Passion and Creativity Shine at High School Science Fair
Junior Ethan Knight went in-depth on his weightlifting hobby for this year’s high school science fair. For research, he and his friends tested the ways music impacted their performance at the gym.
Hims & Hers responds to FDA pressure, pulls knockoff Wegovy drug launch after regulatory threats
Telehealth company Hims & Hers cancels $49 monthly weight loss drug launch following FDA warnings about unapproved semaglutide compounds and Novo threats.
Highlights! Figueroa Knocks Out Ball In Final Round!
Nick Ball and Brandon Figueroa went to war earlier today (Sat., Feb. 8, 2026) in Liverpool, England for Ball’s WBA Featherweight title in what was an absolute back-and-forth affair. Going into the twelfth and final round, the scores were very tight and it was anyone’s fight to win at that point. But just five seconds […]
Hims & Hers stops selling weight loss pill days after unveiling it
Hims & Hers said it would stop selling its new compounded semaglutide pill after "constructive conversations with stakeholders across the industry."
Record-Breaking One-Off Bugatti Brouillard Could Become the Most Expensive Bugatti Ever
A one-off aimed at a historic record Bugatti’s latest one-off, the Brouillard, steps onto the hypercar stage with the quiet confidence of a record-breaker. The brand’s tradition of bespoke excellence meets a bold new aesthetic, positioning this unique commission to potentially become the marque’s most expensive creation. Built on the proven underpinnings of the Chiron/Mistral architecture, yet transformed by distinctive craft, the Brouillard is both homage and innovation. A name born from equestrian legend More than a century ago, a striking white horse captivated Ettore Bugatti in Molsheim. That equine myth now informs the car’s name and its sensory identity. The result is an automotive portrait of athletic grace—surfaces that read like muscle, curves that suggest motion, and details that quietly speak of discipline and heritage. Embroidered horse motifs on door panels and seat backs echo the story, while a miniature glass sculpture of the steed crowns the shifter. Sculptural design with purpose The Brouillard’s silhouette favors sinuous surfaces over hard creases, allowing light to glide over its form like a tendon under skin. Aerodynamics inform elegance: an integrated ducktail replaces a deployable wing, cleansing the airflow and boosting stability at speed. Its stance is athletic, its volumes taut, and its visual language unmistakably Bugatti. “Sculptural, organic forms—like a tendon beneath the skin—hide immense power behind noble simplicity,” said design chief Frank Heyl, capturing the car’s philosophy in a single stroke. Craft elevated to an art The cabin embraces craftsmanship at an uncommon level. Custom-woven textiles from Paris introduce a discreet tartan pattern, while green-tinted carbon fiber nods to the exterior’s hue. A glazed roof creates a cathedral atmosphere, bathing the cockpit in natural light. A central spine appears to flow from exterior to interior, emphasizing continuity and structure. Highlights include: Custom textiles with subtle tartan motifs Green-tinted carbon fiber matched to the exterior finish A “cathedral” glass roof that elevates cabin ambience A sculptural centerline linking outside to inside Bespoke embroidery and glass equine detail W16 power at its absolute apex Under the sculpted skin, the final evolution of Bugatti’s 8.0‑liter, quad‑turbo W16 delivers a thunderous 1,600 hp at 7,050 rpm and 1,600 Nm of torque. This represents the pinnacle of nearly two decades of Bugatti engineering, honed to an ultimate state. The lightweight monocoque blends carbon fiber with aluminum, holding mass to around 1,900 kg for poise and control. Experts suggest the Brouillard could surpass the 282 mph (454 km/h) achieved by the Mistral, aided by more aerodynamic bodywork and the fixed ducktail. Whether or not it sets a new benchmark, its intent is clear: relentless speed paired with refinement. Exclusivity with an exacting timeline The commissioning process is intensive, with roughly 18 months of development leading to a 2027 delivery. Bugatti’s program limits itself to no more than two creations per year, ensuring focus and rarity. Each example leaves the atelier as a singular vision, shaped to the client’s collection and the brand’s ethos. An unveiling is planned for Monterey Car Week 2025, placing the Brouillard amid the world’s most discerning enthusiasts. Its patron is a European collector deeply invested in the Bugatti universe, from historic and modern cars to Carlo Bugatti furniture and Rembrandt Bugatti bronzes. A valuation poised to make history While Bugatti has not disclosed an official price, informed estimates place the Brouillard between €10 million and €30 million. Context matters: a series Mistral begins near €5 million, while the Brouillard adds profound personalization, sculptural changes, and a pace of production that keeps scarcity front and center. In an arena where uniqueness drives value, the path to a brand record is unmistakably open. What it signals for the marque The Brouillard crystallizes Bugatti’s dual identity: traditional savoir‑faire intertwined with boundary-pushing performance. It exhibits a narrative soul—the white horse of Molsheim—woven into modern materials and world-class aerodynamics. As a rolling statement, it reaffirms that the Bugatti idea is larger than speed alone; it is about story, craft, and the courage to pursue an ideal to its logical limit.