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Extendend interview: Dr Roham Alvandi on Iran, Britain, and the futures that might have been
From Cold War power games to the cultural aspirations of the Pahlavi era, this extended conversation pulls back the curtain on the global forces that continue to shape - and be shaped by - Iran today. Dr Roham Alvandi is Director of the Iranian History Initiative at the London School of Economics and Political Science.
Lessons from Binghamton led alumni award winner to public health
Clare Biging ’16 is an epidemiologist and public health advocate at the New York City Department of Health and Mental Hygiene.
Wisconsin edges Ohio St., wins another title at Frozen Four
Claire Enright scored the go-ahead goal in the third period Sunday, Ava McNaughton had 34 saves, and No. 2 seed Wisconsin beat top-seeded Ohio State 3-2 at the Frozen Four to win its second consecutive national championship.
Ducks Sign Herman Träff to Entry-Level Contract
The 20-year-old had 41 points in 51 games this season for Oskarshamn in the HockeyAllsvenskan.
Notre Dame men join women in winning inaugural three-weapon title
Notre Dame's Ahmed Hesham won the men's saber Sunday, and the Fighting Irish men joined the women in winning the inaugural three-weapon national championship at the Joyce Center.
Florida vs Iowa live updates: Prediction, how to watch March Madness Round 2 game
Defending national champion Florida didn't need a warm-up to get going in their NCAA title defense. Will Iowa provide any resistance in March Madness?
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Syracuse finalizing Gerry McNamara hire: Siena coach helped lead Orange to 2003 national championship
McNamara just finished guiding Siena to the NCAA Tournament, where it almost upset No. 1 Duke
Box Office: ‘Project Hail Mary’ blasts off with $80.5 million, a best for Amazon MGM
Studio estimates on Sunday say Amazon MGM's “Project Hail Mary” has topped the North American box office charts with $80.5 million in ticket sales.
The Cincinnati's Favorite Beer 2026 winner is ... (drumroll please)
Our new beer bracket champ had a difficult path to the crown. The final suds match was Vlad (Fretboard) vs. Dunkel (Hofbrauhaus). So, who won!?
Maine progressive Senate candidate Graham Platner responds to Gov. Janet Mills’ attack on his online past
Purdue vs Miami live updates: Prediction, how to watch March Madness Round 2 game
Braden Smith has the NCAA assists record, now he can focus on his main goal: a championship. Miami stands in Purdue's way in Round 2 of March Madness.
'Saturday Night Live UK' aims to take a comedy hit across the pond. The first verdicts are in
A British version of “Saturday Night Live” has debuted to largely positive reviews.
'Saturday Night Live UK' aims to take a comedy hit across the pond. The first verdicts are in
A British version of “Saturday Night Live” has debuted to largely positive reviews.
Titans sign ex-Browns linebacker
The Titans have signed former Browns linebacker Mohamoud Diabate to a contract after he wasn't tendered as an RFA.
Pompey's hopes of staying up now unsure
BBC Radio Solent commentator Andrew Moon gives his thoughts following Portsmouth's 6-1 defeat at Queens Park Rangers in the Championship.
Boys' basketball coach of the year: Mike LeDuc of Damien
The second-winningest coach in California high school history guided Damien to the state Division I championship.
In Maine’s marquee Senate primary, Janet Mills reaches out to women by raising Graham Platner’s online past
Janet Mills and her allies are counting on a gender gap to narrow Platner’s wide lead ahead of the June 9 primary to decide who will face incumbent Republican Sen. Susan Collins. They are betting that the unfiltered style that has brought Platner widespread attention as someone who could help Democrats reach young men will backfire with women.
Girls' basketball coach of the year: Alicia Komaki of Sierra Canyon
She came up with a winning formula to defeat Etiwanda and No. 1 Ontario Christian in the Southern Section Open Division championship.
The Times' final top 25 high school boys' basketball rankings
Sierra Canyon, the state Open Division champion, finishes No. 1 in The Times' final 2025-26 high school boys' basketball rankings.
Trump touted bigger tax refunds this year, but Americans will likely spend them on gas
Spiking gas prices in the U.S. are on track to eat up tax refunds this year, leaving most Americans with little extra to spend.
I'm glad my daughter was rejected from an Ivy League college
My daughter had her sights set on Brown University, but the Ivy League rejected her. Thankfully, she went to Fordham where she found her true passion.
Southland girls' basketball final rankings for 2025-26 seaosn
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See what students from New Hampstead High wore for their 2026 prom
Students from New Hampstead celebrate their 2026 high school prom at Red Gate Farms.
New law firm formed; new executive director at chamber; hospital picks new chief of staff
Take a look at some of the recent promotions and new hires announced at south Louisiana businesses.
Warriors drop third straight with 126-110 loss vs. Hawks
The Warriors had no answer for Dyson Daniels, CJ McCollumn and the Hawks on Saturday in a 126-110 loss.
Barricade That Kept Out the Far Right in France Is Crumbling
Franck Leclere made his way through the timber-framed houses of Chalons-en-Champagne and joined a crowd of people in symbolic white shirts to demonstrate against the rise of the far right in France.
Marc Abrahams, founder of the satirical Ig Nobel Prizes: ‘Scientists in the US are very angry. People are waking up’
The awards are moving to Switzerland, because their founder believes he can no longer guarantee the laureates’ safety in the United States
Madison Black Chamber of Commerce prepares 8th business awards recognition program
The Madison Black Chamber of Commerce is hosting its 8th Black Business Awards Recognition and Exhibition Program on Thursday.
OU women's gymnastics senior Faith Torrez scores perfect 10, while Sooners lose in SEC championship
No. 1 OU women’s gymnastics (18-1-1) finished second in the Southeastern Conference Championship against No. 3 Florida (15-2-0), No. 2 LSU (12-5-1) and No. 4 Alabama (9-8-0) Saturday, with the
Tottenham Hotspur have chance to turn relegation narrative around against Nottingham Forest
Both sides are barely hovering above the relegation zone, Spurs boasting one point over 18th-place West Ham while Nottingham are only above the drop zone on goal differential
Coaches in elite company clash when Kansas faces St. John's
SAN DIEGO -- Only three active head coaches in Division I college basketball have won multiple national championships. Two of them meet for a berth in the Sweet 16 when Bill Self's No. 4 Kansas Jayhawks face Rick Pitino's No. 5 St. John's Red Storm on Sunday in the second round of the NCAA Tournament East Region.
Curzan lifts Virginia women to sixth straight NCAA swim title
Claire Curzan finished off a sweep in the backstroke on Saturday to help lead the Virginia women to their sixth straight NCAA swimming and diving championship on Saturday.
Goodrich polishes off perfect season with MHSAA girls basketball title
Goodrich beat Tecumseh, 55-44, in the MHSAA girls basketball Division 2 state championship on Saturday, March 21 in East Lansing.
UCLA overcomes broken tooth and stubborn UCF 75-71
UCLA remains in the hunt for a 12th national championship
Urban Entertainment Society crowns this year’s Beat Battle champion
The Urban Entertainment Society hosted its annual Beat Battle at the Chris Young Cafe on Friday, highlighting talented students across every major.
Jaebri'an Autry ends Detroit Renaissance career with heartbreak
Muskegon beat Detroit Renaissance 34-29 in the MHSAA girls basketball Division 1 state championship game on Saturday, March 21 in East Lansing.
Senate rejects Trump-backed measure to ban trans athletes in female sports
The chamber considered adding the measure to a far-reaching voting bill supported by the Republican president.
Shame on ABC for casting Taylor Frankie Paul on 'The Bachelorette' — they're getting what they deserve
Wrexham’s Hollywood owners’ Sky Sports’ watchalong criticised by Swansea CEO
Sky offered an alternative commentary with Wrexhman owners Ryan Reynolds and Rob Mac alongside regular presenter David Prutton.
Farmers and rural community members can access free mental health resources
KGAN CBS 2 and KFXA Fox 28 provide local news, weather forecasts, notices of events and items of interest in the community, sports and entertainment programming for Cedar Rapids and nearby towns and communities in the Corridor and throughout eastern Iowa, including Iowa City, Waterloo, Dubuque, North Liberty, Coralville, Marion, Morengo, Williamsburg, Washington, Tiffin, Tipton, Solon, Mount Vernon, Lisbon, Central City, Urbana, Independence, Manchester, Dyersville, Oelwein, Cedar Falls, Waverly, Evansdale, Guttenberg, West Union, New Hampton, Decorah, Waukon, Maquoketa, Sigourney, Fairfield, Grundy Center, La Porte City, Dysart, Fayette, Elkader, Strawberry Point and Belle Plaine.
Big money flows into state attorney general races as legal battles shape American politics
There are races in 30 states this year for attorney general, and groups that support those candidates prepared for the elections by raising record amounts in 2025.
Tottenham eye transfer move for Freiburg’s Noah Atubolu
Tottenham Hotspur have watched Freiburg’s Noah Atubolu as they search for goalkeeping reinforcements this summer, according to the Daily Mail.Tottenham need a new goalkeeper, with Guglielmo Vicario ...
Basketball box scores, other sports results for Friday, March 20, 2026; Playoff schedule
FRIDAY’S RESULTS Boys Basketball PIAA CLASS 5A PLAYOFFS Championship Bonner-Prendergast 62, West York 35 Bonner-Prendergast 8 14 15 25 — 62 West...
‘Hearing a lot from military families’: Local mental health provider reports surge in calls since conflict in Iran began
Since Feb. 28, what officials describe as an escalation in hostilities involving the United States, Israel and Iran has had ripple effects across the United States, from the stock market to gasoline prices and residents’ mental health.
Former Rams 5th-round edge rusher signing with Panthers
Former Rams OLB Nick Hampton, who was a fifth-round pick in 2023, is signing with the Panthers.
The mental health effects of gun violence near schools
Dr. Scott Hadland from Mass. General Brigham discusses new data that shows the amount of shootings near schools is trending downwards.
Human Consciousness Is an Illusion, Scientists Say
The entire universe may have an internal mind—or the whole idea of consciousness could be a sham. Here’s why scientists still can’t agree.
How to watch 2026 NCAA swimming and diving championships
It's time for the 2026 NCAA swimming and diving championships! Here's how to catch the action on ESPN+.
Shelby’s Trio hosts Chamber of Commerce Business After Hours
Shelby's Trio hosted the Clarksville Area Chamber of Commerce Business After Hours event on Thursday.
Family-focused venue The Block Jax opens in Deerwood with food vendors, live music, dog park & more
Whether you want to catch the big game or take the family out for a night, The Block Jax, Jacksonville’s first outdoor food hall, made its debut on Friday with a grand-opening celebration continuing through Sunday.
Chuck Norris, action hero and ‘Walker, Texas Ranger’ star, has died
Chuck Norris, veteran, martial arts world champion, action hero and early 2000s Internet meme inspiration, whose rugged demeanor was immortalized on hit show “Walker, Texas Ranger,” has died.
Chaminade softball team become surprise team in Mission League
Eagles upset defending champion Sherman Oaks Notre Dame 7-6 for their seventh consecutive win behind Casey Glantz and Finley Suppan.
Welcome 2 New Restaurants to East Carson Street Business District
Mayor O'Connor and South Side Chamber of Commerce Welcome 2 New Restaurants to East Carson Street Business District
Contributor: A Democratic takeover of the Senate is now imaginable
For the first time, prediction markets are indicating Republicans will lose both chambers in November.
How Muslim Businesses in New York Prepare to Celebrate Eid
From Fordham to Bay Ridge to Hollis, Muslim businesses get ready for Eid al-Fitr, the exultant celebration marking the end of the holy month of Ramadan.
Why did Olivia Miles transfer to TCU from Notre Dame? What to know about star guard
Olivia Miles made the TCU Horned Frogs national championship contenders when she transfered. Here's what to know about the four-time All-American.
David Lynch heaps praise on ‘absolutely brilliant’ Liverpool star
Liverpool 4-0 Galatasaray: Dominik Szoboszlai Leads Ruthless Charge into Champions League Quarter-FinalsLiverpool’s emphatic 4-0 win over Galatasaray at Anfield has reignited belief, and much of tha...
2026 March Madness: What Makes an NCAA Tournament Champion?
March Madness is here, and FOX Sports Research has done a historical deep-dive into the characteristics that make up a tournament champion.
Recap: CCST Science & Technology Week 2026 - California Council on Science & Technology (CCST)
CCST’s 9th annual Science & Technology Week brought together policy leaders, science and technology experts, CCST champions, and our incredible network of partner institutions to discuss some of the state’s biggest challenges and opportunities
Figma's stock drops 11% in two days after Google releases 'vibe design' product
Figma's stock has been getting hammered on concerns about AI, and Google's new design product is adding to that anxiety.
Medical expert explains why Cade Cunningham's collapsed lung likely isn't as bad as it sounds
'These guys are so athletic, they can bounce back like crazy,' a doctor told CBS Sports
Phillies and Aramark Sports + Entertainment Announce What’s New in the 2026 Food Experience at Citizens Bank Park
With just one week until the reigning, back-to-back NL East champions return for the home opener, the Philadelphia Phillies and Aramark Sports + Entertainment today announced an exciting new lineup of food offerings and experiences coming to Citizens Bank Park for the 2026 season. Highlights include the debut of new
NCAA Wrestling Championships live updates: Start time, TV channel for Day 1
Day 1 of the 2026 Men's NCAA Wrestling Championships are underway from Cleveland. Follow along as for live updates, highlights and team scores:
How YouTuber Caleb Hammer built a big business on debt call-outs
Caleb Hammer, who built a large audience by blending personal drama with money advice, has parlayed that into a lucrative subscription business.
Longtime Royal Oak vintage store's owner is taking shop upscale
Tommy Dorr, who said vintage shopper tastes have shifted since the pandemic, hadn't considered the retail district along North Old Woodward.
Panthers 'embrace' Challenge Cup win
Reclaiming the Challenge Cup for the first time in a decade is a triumph Nottingham Panthers will cherish, says head coach Danny Stewart.
How Barcelona exploited Magpies' defensive weakness
Champions League Match of the Day pundits Stephen Warnock and Nedum Onuoha look at how Barcelona were able to repeatedly expose Newcastle United's centre-backs Dan Burn and Malick Thiaw during their 7-2 victory in the second leg of their last-16 tie.
Benidorm's champion 'opening gate' for MMA in Spain
Home favourite Costello van Steenis defends his PFL middleweight title against Britain's Fabian Edwards in Madrid on Friday in the largest MMA event to ever take place in Spain.
Prep baseball roundup: Sherman Oaks Notre Dame is off to a 9-0 start
Malakye Matsumoto's pitching and hitting leads Knights to 11-0 win over Chaminade.
STEM vending machine installed at Rochester Academy of Science
A school in the city is serving up science in a unique way.
Messi scores 900th career goal in Inter Miami cup clash
Argentine superstar Lionel Messi bagged the 900th goal of his glittering career on Wednesday, scoring for Inter Miami in their CONCACAF Champions Cup clash with Nashville.- Clinical finish - The Argentine World Cup winner's 900th goal came early in Miami's last-16 second leg tie with MLS rivals Nashville.
'Love Is Blind' stars made it a point not to discuss politics during the show
Christine Hamilton and Vic St. John said politics can sometimes be used as an excuse to leave a relationship.
Champions League results: Liverpool, Bayern Munich comfortably advance; Barcelona routs Newcastle
Liverpool will meet PSG and Bayern Munich will take on Real Madrid in the quarterfinals.
Liverpool 4-0 Galatasaray (Agg: 4-1): Reds turn Champions League tie around to set up PSG quarter-final
Houston Health Department temporarily shuts down ‘Mama Tina’s Gumbo’ at RodeoHouston
The Houston Health Department (HHD) has confirmed that ‘Mama Tina’s Gumbo’ was temporarily shut down at the Houston rodeo.
Champions League scores: Live updates as Barcelona face Newcastle, Liverpool, Tottenham Hotspur in action
All six English teams entered this week after going winless in the first leg, with only Arsenal booking a spot in the quarterfinals so far
Q&A: Is there no shame left in politics?
There is some, a UVA expert says, but the public has become accustomed to bad behavior.
🧪 Science with Sarah: Invisible ink 🕵️
Let your kids use the power of science to hone their spy skills.
Gavin Adcock ‘The Day I Hang It Up Tour’ includes two Alabama shows: Act fast and secure your tickets
Fans can catch Adcock at popular venues in Orange Beach and Birmingham later this year.
Local farmer says entering politics 'shouldn't be daunting'
In part 2 of NEPM's series on newcomers entering politics, Easthampton, Mass., poultry farmer Karl Prahl reflects on how losing a campaign pushed him into community service.
Local farmer says entering politics 'shouldn't be daunting'
In part 2 of NEPM's series on newcomers entering politics, Easthampton, Mass., poultry farmer Karl Prahl reflects on how losing a campaign pushed him into community service.
Local farmer says entering politics 'shouldn't be daunting'
In part 2 of NEPM's series on newcomers entering politics, Easthampton, Mass., poultry farmer Karl Prahl reflects on how losing a campaign pushed him into community service.
Platner responds to Mills’ ad highlighting past comments
The ad quoted Platner writing that if women want to avoid rape they should make sure they don’t get so altered that “they wind up having sex with someone they don’t mean to” and that they should “act like an adult.”
TikTok's global consumer marketing head is out, part of job cuts
TikTok's consumer marketing lead Zuber Mohammed has left the company. He oversaw brand and creative marketing efforts.
Nasal Swab Test Spots Early Alzheimer’s Signals
DURHAM, N.C. – Alzheimer’s disease affects millions of people worldwide, yet the illness is hardest to catch at the very beginning, when new treatments may work best.In a new study, Duke Health researchers show that a quick, outpatient nasal swab can pick up early biological changes linked to Alzheimer’s, even before thinking and memory problems appear.
Filip Nowacki named Jersey Sports Person of the Year for 2025
World Junior swimming champion Filip Nowacki is named Jersey's Sports Person of the Year.
Georgia WBB on 'a business trip' in Iowa City for March Madness
For Georgia women's basketball coach Katie Abrahamson-Henderson, Saturday is just another business trip. Here's why.
Meet the Mid-Penn Conference winter sports all-stars
See who made the Mid-Penn Conference all-star winter teams in basketball and wrestling.
Five new cases of meningitis in Kent, UK Health Security Agency confirms
Two people have died in the outbreak - a 21-year-old university student and Juliette, a sixth form pupil at Queen Elizabeth's Grammar School in Faversham.
Gossip: Spurs could target Savinho in summer
Manchester City could let Brazilian winger Savinho, 21, leave in the summer and Tottenham are possible suitors if they retain their Premier League status. (Football Insider)
Jersey students call for 'a more political curriculum'
A number of students attended a debate in the States chamber.
Enzo Fernandez coy on Chelsea future following PSG loss
Chelsea midfielder Enzo Fernandez kept his cards close to his chest regarding a transfer away from Stamford Bridge following their Champions League exit at the hands of Paris Saint-Germain.The Argenti...
How a ‘locked in’ offseason prepared Spurs for championship push
In clinching the Spurs first 50-win season in almost a decade, Victor Wembanyama pointed back to before the season started.
Cote: Baseball, politics, emotion lift Venezuela to WBC crown over U.S.
It was baseball first, but politics, too, that made Venezuela the World Baseball Classic champion over the favored U.S. Tuesday on an emotional night in Miami
World Baseball Classic: Venezuela takes down Team USA in championship game stunner
Venezuela has its first World Baseball Classic title.
Minnesota fires women's hockey coach Frost after 19 seasons
Minnesota dismissed women's hockey coach Brad Frost on Tuesday after 19 seasons, a decade since the program's last national championship.