SCROLL NEWS / DISCOVERY

Search headlines

Find the stories shaping the conversation.

Search mode
Refine results
Active filters Keyword All time

Results for " inter " 13,367 found 🔀 AI-powered Shuffle

NYC Health + Hospitals/Woodhull Earns National Recognition as Center of Excellence in Surgical Safety - NYC Health + Hospitals

NYC Health + Hospitals/Woodhull today announced it received the Center of Excellence in Surgical Safety: Prevention of Retained Surgical Items (RSI) Award

nychealthandhospitals.org logo
Mar 25 • 11:36 AM EDT • Health • nychealthandhospitals.org
Microsoft makes sweeping overhaul of HR organization, internal memo shows

Microsoft's Chief Diversity Officer Lindsay-Rae McIntyre is leaving the company on March 31.

businessinsider.com logo
Mar 25 • 11:35 AM EDT • Business • businessinsider.com
Supreme Court says that internet service provider isn’t liable for bootlegged music downloads

In a major loss for the nation’s music industry, the Supreme Court on Wednesday ruled that a major internet service provider is not liable for copyright infringement because it failed to kick known copyright violators off its network.

cnn.com logo
Mar 25 • 10:50 AM EDT • Politics • cnn.com
Supreme Court tosses $1B copyright verdict in record companies' battle over illegal internet downloads

The Supreme Court unanimously ruled Wednesday that internet providers are not liable for copyright infringement by their users, delivering an opinion in Cox v. Sony and tossing a $1 billion verdict.

foxbusiness.com logo
Mar 25 • 10:28 AM EDT • Business • foxbusiness.com
Glyphosate: A story of science, risk, and nuance

In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe

yourlocalepidemiologist.substack.com logo
Mar 25 • 10:25 AM EDT • Science • yourlocalepidemiologist.substack.com
Longtime ESPN Hosts Endorse Celtics' Jaylen Brown For MVP Award

Pardon The Interruption's Michael Wilbon and Tony Kornheiser both backed Jaylen Brown as this season's rightful NBA MVP.

sports.yahoo.com logo
Mar 25 • 10:18 AM EDT • Sports • sports.yahoo.com
Black Troops, White Rage, and Political Violence in the Postbellum American South -

By Joshua Byun, Boston College and Hyunku Kwon, University of Chicago How can governments in racially divided societies protect vulnerable populations from political violence after large-scale internal conflict? When the dominant majority is bent on [...]

politicalsciencenow.com logo
Mar 25 • 10:00 AM EDT • Politics • politicalsciencenow.com
Colby Covington plans to step away from politics after President Trump leaves office

Colby Covington plans to step away from politics after Trump’s second term Colby Covington says he plans to step away from politics once Donald Trump’s second term comes to an end. The former interim UFC welterweight champion has built much of his persona around his support for Trump, even bringing a belt to the Oval Office back in 2018.

sports.yahoo.com logo
Mar 25 • 9:46 AM EDT • Politics • sports.yahoo.com
Today on OTM: Is it Opening Day?

Good morning and happy Opening Day! Except… is it actually Opening Day? There is a regular season baseball game today. But there’s only one of them. And it’s at night. And it’s on Netflix. And it’s an interleague game featuring a team that didn’t even make the postseason last year. And it seems to be […]

sports.yahoo.com logo
Mar 25 • 9:44 AM EDT • Sports • sports.yahoo.com
😐 Neutral (10%)
ahah
43%
wow
36%
love
21%
Trump Retained Classified Documents Because Of His ‘Business Interests,’ Jack Smith Alleged

Trump allegedly showed a classified map to people aboard his private plane, Smith found during his investigation.

forbes.com logo
Mar 25 • 8:52 AM EDT • Business • forbes.com
UK Should Ban Crypto Donations to Political Parties, Review Says

The UK should ban crypto donations to political parties until they are effectively regulated because they risk foreign financial interference in British politics, according to a government-commissioned review into the matter.

bloomberg.com logo
Mar 25 • 8:39 AM EDT • Politics • bloomberg.com
RPI Athletics Celebrates 50 Years of Women's Sports

Rensselaer Polytechnic Institute proudly celebrates 50 years of women's varsity athletics—a milestone that reflects decades of progress, achievement, and opportunity for generations of student-athletes. What began as a commitment to expanding access in intercollegiate athletics has grown into a vibrant and competitive tradition that continues to shape the RPI community today.

rpiathletics.com logo
Mar 25 • 8:00 AM EDT • Sports • rpiathletics.com
Inter Miami CF Announces Heron Sports & Entertainment as Club Continues Unprecedented Growth

Heron S&E to serve as promoter of major entertainment events both locally at their new home at Miami Freedom Park, Inter Miami CF Stadium in Fort Lauderdale, the Florida Blue Training Center, and globally Continuing to push the boundaries in the global entertainment landscape, Inter Miami CF is excited to

intermiamicf.com logo
Mar 25 • 7:57 AM EDT • Entertainment • intermiamicf.com
Inter Miami CF Announces Heron Sports & Entertainment as Club Continues Unprecedented Growth

Heron S&E to serve as promoter of major entertainment events both locally at their new home at Miami Freedom Park, Inter Miami CF Stadium in Fort Lauderdale, the Florida Blue Training Center, and globally Continuing to push the boundaries in the global entertainment landscape, Inter Miami CF is excited to

intermiamicf.com logo
Mar 25 • 7:57 AM EDT • Sports • intermiamicf.com
Compilation of Events Supported by Heron Sports & Entertainment

With the opening of Nu Stadium in Miami, Heron Sports & Entertainment, the dedicated platform focused on arranging, promoting, and producing major events in South Florida and Globally enters a new era. Since opening its doors in 2020, the Club’s state-of-the-art facilities have staged hundreds of events including Major International

intermiamicf.com logo
Mar 25 • 7:54 AM EDT • Sports • intermiamicf.com
Compilation of Events Supported by Heron Sports & Entertainment

With the opening of Nu Stadium in Miami, Heron Sports & Entertainment, the dedicated platform focused on arranging, promoting, and producing major events in South Florida and Globally enters a new era. Since opening its doors in 2020, the Club’s state-of-the-art facilities have staged hundreds of events including Major International

intermiamicf.com logo
Mar 25 • 7:54 AM EDT • Entertainment • intermiamicf.com
Random: "Blink Twice If You Need Help" - The Internet Dunks On Ex-WWE CEO For Claiming PSP Was "The Beginning Of Life On The Go"

"What the f**k are you talking about, Linda"

timeextension.com logo
Mar 25 • 7:05 AM EDT • Technology • timeextension.com
Democracy Depends on Science—So Scientists Need to Show Up for Democracy

A shared commitment to facts and knowledge, produced independently from political interference, is critical to democracy—and worth fighting to protect.

blog.ucs.org logo
Mar 25 • 7:00 AM EDT • Science • blog.ucs.org
Health Care Roundup: Market Talk

Find insight on Cochlear, Peloton Interactive, Chinese healthcare companies and more in the latest Market Talks covering Health Care.

wsj.com logo
Mar 25 • 6:14 AM EDT • Health • wsj.com
Smith memo: Trump had classified docs shared with just 6 people, others tied to his business interests

Among the classified records taken to Mar-a-Lago by President Trump were documents so sensitive that one had been distributed to just six people, while another set was relevant to his business inte…

thehill.com logo
Mar 25 • 5:00 AM EDT • Business • thehill.com
Review of foreign financial interference in UK politics to be published, with ban on crypto donations expected

Ministers will publish review by Philip Rycroft, which will make recommendations relevant to all the political parties, today

theguardian.com logo
Mar 25 • 4:53 AM EDT • Politics • theguardian.com
Deep dive
😐 Neutral (6%)
wow
57%
ahah
43%
Hubert Davis out as UNC coach after five years, ushering in historic break from Carolina family tradition

A stunning NCAA Tournament collapse, eroding donor support and mounting internal pressure culminated in North Carolina cutting ties, a move that breaks the program's 70-year coaching lineage

cbssports.com logo
Mar 24 • 9:00 PM EDT • Sports • cbssports.com
Deep dive
😐 Neutral (5%)
wow
66%
love
34%
Health Ring Oura Interviews Banks for IPO as Soon as This Year

Health ring Oura has been interviewing bankers to advise on an initial public offering that could take place as soon as this year, according to a person with direct knowledge of discussions. A public offering would follow fast growth at the company, which sells connected devices—which cost from ...

theinformation.com logo
Mar 24 • 4:46 PM EDT • Health • theinformation.com
Tampa Bay Rays, Rowdies announce wave of internal promotions

The promotions come as the Tampa Bay Rays push for public funding for a new ballpark and mixed-use district in Tampa.

floridapolitics.com logo
Mar 24 • 4:40 PM EDT • Politics • floridapolitics.com
LISA Symposium Reminder: Travel Grant Applications Due

The 16th International LISA Symposium will be taking place in College Park, Maryland on 21-26 June 2026.

science.nasa.gov logo
Mar 24 • 4:19 PM EDT • Science • science.nasa.gov
😐 Neutral (12%)
love
67%
wow
33%
Accelerating Innovative and Effective Pediatric Health Care Delivery Systems: Interventions and Value-Based Care Models for Children with Chronic Health Conditions and Complex Social Needs

Children, youth, and families have unique health needs, which set the foundation for health across the life course; chronic conditions now affect nearly one in three U.S. children, with disproportionate prevalence in those enrolled in Medicaid and CHIP.

aspe.hhs.gov logo
Mar 24 • 3:57 PM EDT • Health • aspe.hhs.gov
Hochul reiterates legislative proposals on ghost gun crackdown

Those include requiring all 3D printers sold in New York state have technology stopping it from creating anything related to ghost gun parts.

spectrumlocalnews.com logo
Mar 24 • 2:51 PM EDT • Politics • spectrumlocalnews.com
Hornets eyeing entertainment district around Spectrum Center

The Charlotte Hornets leadership says they are still interested in an entertainment district around the Spectrum Center.

sports.yahoo.com logo
Mar 24 • 2:09 PM EDT • Entertainment • sports.yahoo.com
😐 Neutral (4%)
wow
67%
love
33%
Marathon has sold 1.2M copies across Steam, PS5, and Xbox

Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]

alineaanalytics.substack.com logo
Mar 24 • 2:06 PM EDT • Technology • alineaanalytics.substack.com
Joy Behar skips 'View' interview with Carrie Underwood after criticizing Trump performance

Joy Behar left 'The View' table Tuesday morning, skipping an interview with Carrie Underwood after publicly criticizing the 'American Idol' winner's decision to perform at Donald Trump's inauguration.

ew.com logo
Mar 24 • 1:14 PM EDT • Entertainment • ew.com
NEA Business Notes: RightFiber expands into North Texas - Talk Business & Politics

Jonesboro-based RightFiber is expanding its 100% fiber optic internet with a more than $50 million investment in north Texas. RightFiber brings speeds up to 5 gigabytes to homes and up...

talkbusiness.net logo
Mar 24 • 1:00 PM EDT • Business • talkbusiness.net
'We Will Do It' — Marvel Rivals Dev Confirms Nintendo Switch 2 Version in the Works

Marvel Rivals is officially coming to the Nintendo Switch 2, according to its developers in an interview with IGN. We just don't know when.

ign.com logo
Mar 24 • 12:51 PM EDT • Technology • ign.com
Palantir Will No Longer Profit Off of New Yorkers’ Health Data

After The Intercept exposed Palantir’s deal with New York City Health + Hospitals, the public health care system didn’t renew the contract.

theintercept.com logo
Mar 24 • 12:23 PM EDT • Health • theintercept.com
NYC Health + Hospitals/Gotham Health Receives Over $1 Million from Queens Borough President Donovan Richards Jr. to Enhance Patient Care Across Queens - NYC Health + Hospitals

Queens, NY — NYC Health + Hospitals/Gotham Health today announced a significant investment of over $1 million from Queens Borough President Donovan

nychealthandhospitals.org logo
Mar 24 • 12:20 PM EDT • Health • nychealthandhospitals.org
Long lines at Texas airports continue as ICE agents assist strained TSA

Houston remains the only Texas city where ICE agents are currently assisting at airports, with personnel spotted at both William P. Hobby Airport and George Bush Intercontinental Airport.

spectrumlocalnews.com logo
Mar 24 • 10:35 AM EDT • Politics • spectrumlocalnews.com
Scientists Develop New Gut Health Measure That Tracks Disease

Scientists have identified a new way to distinguish healthy guts from diseased ones and track how some illnesses progress by measuring how gut bacteria interact with one another. According to a study published in Science, a Rutgers-led team of scientists found that healthy and diseased digestive systems behave like two distinct ecological states, driven not by individual microbes but […]

sebsnjaesnews.rutgers.edu logo
Mar 24 • 10:33 AM EDT • Health • sebsnjaesnews.rutgers.edu
Deep dive
😐 Neutral (10%)
wow
64%
ahah
36%
World TB Day: Scaling workplace healthcare interventions

Four lessons from the End Workplace TB initiative could help other private sector-led campaign coalitions to scale their workplace healthcare programmes.

weforum.org logo
Mar 24 • 9:36 AM EDT • Health • weforum.org
Johannes Høsflot Klæbo on becoming the greatest Winter Olympian
cnn.com logo
Mar 24 • 9:30 AM EDT • Sports • cnn.com
CT bill seeks to reduce business tax on energy, boost state tourism and international trade

State lawmakers are considering a wide-ranging proposal aimed at reducing business costs, increasing municipal revenue and expanding international trade.

hartfordbusiness.com logo
Mar 24 • 9:28 AM EDT • Business • hartfordbusiness.com
Scientists Must Speak Clearly, Especially in Court: Five Tips for Clear Communication

As climate impacts intensify, so does the legal push to hold polluters accountable, protect vulnerable communities, and enforce environmental laws. And in these legal cases, science is key. Because science can’t present itself on the stand, scientists are essential to give scientific results a voice

blog.ucs.org logo
Mar 24 • 9:00 AM EDT • Science • blog.ucs.org
Alliant Private Client Strengthens Entertainment Practice with Addition of Michelle Quintero

IRVINE, Calif., March 24, 2026--Michelle Quintero has joined Alliant Insurance Services as Executive Vice President with Alliant Private Client. Based on the West Coast and recognized by Risk & Insurance® as a 2026 Entertainment, Hospitality & Gaming Power Broker®, Quintero brings more than 25 years of technical acumen and delivers tailored solutions to high-profile and celebrated individuals in music, film, and live events.

finance.yahoo.com logo
Mar 24 • 8:05 AM EDT • Entertainment • finance.yahoo.com
Steven Corcelli named William K. Warren Foundation Dean of the College of Science

Steven A. Corcelli, professor of chemistry and biochemistry at the University of Notre Dame, has been appointed the William K. Warren Foundation Dean of the College of Science by University President Rev. Robert A. Dowd, C.S.C., effective April 1. Corcelli, who has served as interim science dean since July, was selected through a comprehensive national search launched after his predecessor, Santiago Schnell, was appointed as Dartmouth’s provost.

news.nd.edu logo
Mar 24 • 8:00 AM EDT • Science • news.nd.edu
Carbonsphere launches for carbon science and net-zero solutions

Tsinghua University Press is pleased to announce the launch of Carbonsphere, a new open-access, peer-reviewed journal dedicated to carbon science, technology, and policy. Sponsored by Qinghai University and Tsinghua University and published by Tsinghua University Press, the journal creates a new interdisciplinary platform for research spanning natural systems, engineered systems, and human systems.

eurekalert.org logo
Mar 24 • 8:00 AM EDT • Science • eurekalert.org
March fixture list for Arsenal’s 14 internationals

Following five withdrawals, 14 Arsenal players will be involved in the March internationals, so let’s take a look at when they’ll all be in action.Photo by Michael Campanella/Getty ImagesThe vario...

sports.yahoo.com logo
Mar 24 • 7:35 AM EDT • Sports • sports.yahoo.com
A Veteran Group Jumps In for a Democrat in Iowa Senate Race.

VoteVets is the first super PAC to intervene in the race for Josh Turek, a state legislator who was born with spina bifida after his father was exposed to Agent Orange in Vietnam.

nytimes.com logo
Mar 24 • 5:02 AM EDT • Politics • nytimes.com
As winters warm, Minnesotans grapple with climate grief

Winters in Minnesota are warming faster than any other season. That’s jeopardizing seasonal traditions in the state — and mental health experts say that takes a toll on mental health.

mprnews.org logo
Mar 24 • 5:00 AM EDT • Health • mprnews.org
Home heating oil firms squeezed as diesel, crude prices surge amid Middle East tensions

It's a volatile market for home heating oil businesses. Rising oil and fuel costs after a brutal winter have customers calling and asking for help.

foxbusiness.com logo
Mar 24 • 4:47 AM EDT • Business • foxbusiness.com
The Supreme Court’s conservatives could significantly alter the 2026 election

The Supreme Court on Monday appeared ready to limit mail-in ballots, a move that would reinforce the justices’ pattern of shrinking voter protections and that has, at bottom, favored Republican interests and the Trump administration.

cnn.com logo
Mar 24 • 3:00 AM EDT • Politics • cnn.com
Deep dive
😐 Neutral (7%)
wow
100%
Nets' struggles continue after blowout loss to Trail Blazers

Toumani Camara had career highs of nine three-pointers and 35 points to help Portland beat the Brooklyn Nets 134-99 on Monday night, the Trail Blazers’ largest margin of victory this season.

sports.yahoo.com logo
Mar 24 • 1:06 AM EDT • Sports • sports.yahoo.com
Advent International Acquires Salt & Stone

The premium body care maker will join the private equity firm’s portfolio, which also includes Olaplex and Parfums de Marly.

businessoffashion.com logo
Mar 23 • 11:59 PM EDT • Business • businessoffashion.com
We disagreed on politics. We agreed on wine. That was enough.

At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.

dmwineline.substack.com logo
Mar 23 • 10:54 PM EDT • Politics • dmwineline.substack.com
Deep dive
😐 Neutral (26%)
wow
40%
ahah
30%
love
30%
Supercomputers just solved a 50-year-old mystery about giant stars

Astronomers have finally cracked a decades-old mystery about red giant stars—how material from their deep interiors makes its way to the surface. Using cutting-edge supercomputer simulations, researchers discovered that stellar rotation plays a powerful role in mixing elements across a previously unexplained barrier inside the star.

sciencedaily.com logo
Mar 23 • 8:00 PM EDT • Science • sciencedaily.com
From One Major to Three in Four Years: Connecting Data Science, German and Linguistics at Montclair

In a German language program for local children and on an archive translation project, Isabella Zarate Gonzalez shows how Montclair’s mix of STEM, world languages and community engagement helped her connect her interests into a single path

montclair.edu logo
Mar 23 • 8:00 PM EDT • Science • montclair.edu
How can you explore careers worldwide? Binghamton student founds club to find out

Binghamton University School of Management student Liam Foley discovers how connecting with diverse cultures creates new pathways for success after founding an international business club.

binghamton.edu logo
Mar 23 • 8:00 PM EDT • Business • binghamton.edu
The Monday Outlook: Project Hail Mary and the Science Behind Blockbuster Sci-Fi

Project Hail Mary is the latest sci-fi blockbuster to stretch the bounds of audience imagination and stir the curiosity of real scientists. But the science driving films like Project Hail Mary, Interstellar and The Martian isn’t all fictional: at UChicago, researchers exploring the cosmos and decoding the origins of life are making discoveries that would feel right at home on the big screen. This week's Monday Outlook features scientists from UChicago and Argonne National Laborat

newswise.com logo
Mar 23 • 6:35 PM EDT • Science • newswise.com
Democratic and Republican Party officials face internal backlash after primaries

Party officials have received calls to resign amid endorsements and campaign spending in national and state primary elections.

newsobserver.com logo
Mar 23 • 5:12 PM EDT • Politics • newsobserver.com
Babson and Microsoft Team Up to Help Small Businesses with AI  · Babson Thought & Action

Students from The Generator, Babson’s interdisciplinary AI lab, worked with small business owners to give feedback on a Microsoft AI tool.

entrepreneurship.babson.edu logo
Mar 23 • 3:52 PM EDT • Business • entrepreneurship.babson.edu
NYC Health + Hospitals/Jacobi | North Central Bronx Brings Novel Minimally Invasive Vascular Surgery Procedures to the Bronx - NYC Health + Hospitals

NYC Health + Hospitals/Jacobi | North Central Bronx today announced it has begun offering two types of minimally invasive surgical procedures that were

nychealthandhospitals.org logo
Mar 23 • 1:58 PM EDT • Health • nychealthandhospitals.org
Trump administration to pay French company $1B to walk away from US offshore wind leases

The Department of Interior says a French energy company has agreed to give up two U.S. offshore wind leases and invest in fossil fuel projects instead.

click2houston.com logo
Mar 23 • 1:22 PM EDT • Business • click2houston.com
🙂 Positive (35%)
Cargo Headed to Station, Week Begins with Science Prep and Maintenance

A cargo spacecraft is in orbit catching up to the International Space Station for a docking tomorrow to deliver food and supplies to the Expedition 74 crew. Aboard the orbital lab, the seven residents kicked off the week with science operations prep, routine maintenance, and getting systems ready for a future spacewalk.

nasa.gov logo
Mar 23 • 12:41 PM EDT • Science • nasa.gov
Deep dive
😐 Neutral (13%)
love
67%
wow
33%
Voice of America Journalists Sue, Saying Trump Officials Interfered in Coverage

The journalists said in the complaint that the administration was trying to force them to be a “mouthpiece” and that one official demanded “loyalty” if reporters wanted to “keep their jobs.”

nytimes.com logo
Mar 23 • 12:15 PM EDT • Politics • nytimes.com
Trump admin dumps Biden-era wind projects for billion-dollar investment in US oil

The Trump Department of the Interior secured a landmark agreement with energy giant TotalEnergies to redirect nearly $1 billion away from "unreliable" and "ideological" wind projects.

foxbusiness.com logo
Mar 23 • 11:28 AM EDT • Business • foxbusiness.com
What Giants manager Tony Vitello learned from Steve Kerr, Kyle Shanahan meetings

New San Francisco Giants manager Tony Vitello shared what we took away from his interactions with fellow Bay Area coaches Steve Kerr, Kyle Shanahan.

nbcsportsbayarea.com logo
Mar 23 • 11:21 AM EDT • Sports • nbcsportsbayarea.com
Seven most intriguing offensive additions during the 2026 NFL free agency period

Kyler Murray joining Kevin O'Connell with the Vikings, plus more interesting offensive moves

cbssports.com logo
Mar 23 • 10:06 AM EDT • Sports • cbssports.com
Bridging science and music - College of Arts and Sciences

Graduate student Briana Nave studies music's use and interactions with modern scientific medicine in the early 20th century.

college.unc.edu logo
Mar 23 • 9:23 AM EDT • Science • college.unc.edu
Cowboys mock draft tracker: A trade might make sense early

How interested are you in trading back in the first round?

sports.yahoo.com logo
Mar 23 • 9:00 AM EDT • Sports • sports.yahoo.com
Sewing And Munro Continue Dominance In New Global Sports Alliance International Pickleball Tour With Two Golds In Vietnam

The third event of the new Global Sports Pickleball Alliance saw the tour head to Ho Chi Minh City over the weekend, where Jack Munro and Sofia Sewing both won two golds.

forbes.com logo
Mar 23 • 8:48 AM EDT • Sports • forbes.com
Microsoft Exchange Online service change causes email access issues

Microsoft is working to address an ongoing service issue that has intermittently prevented some users from accessing their cloud-based Exchange Online mailboxes via Outlook mobile and Mac desktop clients since Thursday.

bleepingcomputer.com logo
Mar 23 • 8:17 AM EDT • Technology • bleepingcomputer.com
By Director Mr. Sakurai, Kirby Air Riders: Development Insights — Part 5 - News

Join Kirby Air Riders director Masahiro Sakurai as he shares insights into the development and details behind some of the game's modes and features. Check out the rest of the interview Part 1: Air Ride and Top Ride Part 2: Cramming everything into S…

nintendo.com logo
Mar 23 • 8:00 AM EDT • Technology • nintendo.com
Grub Lab: $6 Million Raised To Bring Sports And Entertainment IP To Independent Restaurants Nationwide

Grub Lab, an Australia-founded restaurant technology startup, announced it has raised $6 million in funding from Quantaco to accelerate its expansion across the United States and support a national rollout tied to major sports leagues and entertainment studios. The company is positioning itself as a modern solution to help independent restaurants compete for family dining traffic through interactive, branded experiences.

pulse2.com logo
Mar 23 • 7:54 AM EDT • Entertainment • pulse2.com
Peace of mind was Mikaela Shiffrin's biggest victory in 2026 Winter Olympics

Olympic legends Mikaela Shiffrin and Simone Biles are fierce advocates for athletes prioritizing their mental health.

usatoday.com logo
Mar 23 • 7:03 AM EDT • Health • usatoday.com
'ET's' archive has William Shatner on a whale and a young Taylor Swift

'Entertainment Tonight' is digitizing and preserving its archive of 45 years of interview set visits and red carpet walks, which include gems like George Clooney's first interview.

latimes.com logo
Mar 23 • 6:00 AM EDT • Entertainment • latimes.com
German men's biathlon coaches stay, women's coaches leave after flop

Tobias Reiter und Jens Filbrich have kept their jobs as coaches of Germany's men's biathlon team despite their equivalents in the women's team leaving their roles. The season which finished on Sunday was hugely disappointing for the former biathlon powerhouses, with just one Olympic bronze medal and no World Cup wins.

sports.yahoo.com logo
Mar 23 • 5:29 AM EDT • Sports • sports.yahoo.com
Letters: Newspapers hold a position in our democracy, unlike any other business

I read with interest Duke Truby's viewpoint about a newspaper print medium being a "business" in the strictest sense. As such, that business should cater to its customers and clients.

nola.com logo
Mar 23 • 1:30 AM EDT • Business • nola.com
😐 Neutral (0%)
The Vogue Business Fall/Winter 2026 Size Inclusivity Report

Size inclusivity on the runway fell again this season, highlighting how far the industry still has to go.

vogue.com logo
Mar 23 • 1:30 AM EDT • Business • vogue.com
Deep dive
😐 Neutral (12%)
wow
39%
ahah
33%
love
28%
Extendend interview: Dr Roham Alvandi on Iran, Britain, and the futures that might have been

From Cold War power games to the cultural aspirations of the Pahlavi era, this extended conversation pulls back the curtain on the global forces that continue to shape - and be shaped by - Iran today. Dr Roham Alvandi is Director of the Iranian History Initiative at the London School of Economics and Political Science.

dw.com logo
Mar 22 • 8:00 PM EDT • Politics • dw.com
IMCOM-E international business advisor helps service members, families with tax relief programs

IMCOM-E international business advisor helps service members, families with tax relief programs

dvidshub.net logo
Mar 22 • 8:00 PM EDT • Business • dvidshub.net
Israel Thought It Could Spur Rebellion Inside Iran. That Hasn’t Happened.

President Trump’s hopes that an Israeli plan to ignite an internal uprising against Iran’s theocratic government could bring the war to a swift end have so far been dashed.

nytimes.com logo
Mar 22 • 2:45 PM EDT • Politics • nytimes.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

erictopol.substack.com logo
Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Messi expected to play, NYCFC vs. Inter Miami live updates

Lionel Messi and Inter Miami shift their focus to MLS play with a matchup against New York City FC at Yankee Stadium on Sunday, March 22.

usatoday.com logo
Mar 22 • 11:45 AM EDT • Sports • usatoday.com
Tom Steyer explains why he should be California's next governor

Tom Steyer sat down for an interview with California Politics 360 for a wide-ranging conversation on his run to be the state's next governor.

kcra.com logo
Mar 22 • 11:25 AM EDT • Politics • kcra.com
70 judges peruse hundreds of science fair projects at Interior science fair

Fourth-grader Lexi Snow wondered why she always blushes.

newsminer.com logo
Mar 22 • 10:00 AM EDT • Science • newsminer.com
Deep dive
😐 Neutral (29%)
wow
44%
ahah
36%
love
20%
Oscar-Winning Alumnus Returns to Pasadena’s ArtCenter for Entertainment Design Expo

One week after winning the Academy Award for Best Animated Feature, KPop Demon Hunters co-director Chris Appelhans returns today to ArtCenter College of Design, the Pasadena campus where he studied illustration, for the college’s third annual Entertainment Design Expo. The expo, known as ENTX, opens the Hillside Campus to the public for a full day of gallery exhibitions, game playtesting, animation screenings and interactive experiences featuring work from more than 200 ArtCenter students and alumni. General admission is free with advance registration. Two industry panels — including Appelhans’s talk — require $15 tickets. Appelhans, who graduated from ArtCenter with a bachelor of fine arts in 2002, co-directed KPop Demon Hunters with Maggie Kang. The animated film, produced by Sony Pictures Animation and released on Netflix, became the streaming platform’s most-watched film in history, according to Netflix, and swept awards season with wins at the Golden Globes, the Annie Awards and the Grammys before taking the Oscar on March 15. His talk and audience Q&A is scheduled from noon to 1 p.m. in the Ahmanson Auditorium. Doors open at 11:30 a.m. The film’s ArtCenter ties extend beyond its co-director. Art director Angela Sung, cinematographer Gary H. Lee, visual development artist Celine Kim and painter Simon Baek are all ArtCenter graduates who worked on the production, according to the college. The free portions of ENTX include a concept design showcase, a production design gallery, a model gallery, a stop motion studio preview, an alumni gallery and a KPop Demon Hunters fan art gallery. Visitors can also playtest games designed by ArtCenter students. An Animation Shorts Showcase runs from 2 to 3 p.m. and includes “Boy, I’m Scared,” a capstone short by ArtCenter graduate Lindsey Tenaglia that was named a semifinalist for the 2025 Student Academy Awards in the animation category. Also screening

pasadenanow.com logo
Mar 22 • 8:30 AM EDT • Entertainment • pasadenanow.com
This floating time crystal breaks Newton’s third law of motion

Scientists have created a new kind of time crystal using sound waves to levitate tiny beads in mid-air. These particles interact in a one-sided, unbalanced way, breaking the usual rules of motion and creating a steady, repeating rhythm. The system is surprisingly simple yet reveals complex physics with big implications. It could help advance quantum computing and deepen our understanding of biological timing systems.

sciencedaily.com logo
Mar 22 • 8:00 AM EDT • Science • sciencedaily.com
UF students celebrate ‘women supporting women’ through new mental health group

According to the Healthy Minds Network’s data interface, a little more than one in three female college students suffered from anxiety in 2025, compared to a little under one in four male students.

alligator.org logo
Mar 22 • 8:00 AM EDT • Health • alligator.org
Thank God for Wyoming — the un-Colorado

Years ago, I interviewed a Canadian health-care broker whose job was helping his countrymen escape their own failing system. When their “free” health care turned into “free to wait until you die,” he’d save his clients by routing them to doctors in the U.S. who’d accept cash and rescue their lives. I asked him what […]

coloradopolitics.com logo
Mar 22 • 7:00 AM EDT • Politics • coloradopolitics.com
Slovenians head to polls in tight race marked by spy scandal

Allegations of espionage and foreign interference have cast a shadow over the parliamentary election

euractiv.com logo
Mar 22 • 2:00 AM EDT • Politics • euractiv.com
The Antidote to Our Growing Crises Must Transcend Politics

Each day, the challenges in our nation pile up. In just recent weeks, there has been the ongoing war in Iran and the Middle East, and ongoing debates about the growing negative impact of the Internet, looming AI challenges, and the Epstein files. The anticipation of divisive, even ugly, midterm elec...

thefulcrum.us logo
Mar 22 • 1:40 AM EDT • Politics • thefulcrum.us
😐 Neutral (0%)
Texas turns key weakness into strength in upset of Gonzaga

Texas overcame early interior struggles to beat Gonzaga 74-68 and reach the Sweet 16. Four Longhorns scored in double figures in Sean Miller's first season.

sports.yahoo.com logo
Mar 21 • 9:39 PM EDT • Sports • sports.yahoo.com
😐 Neutral (15%)
wow
34%
angry
33%
love
33%
Friction without contact discovered as magnetic forces break a 300-year-old law

Researchers have uncovered friction without contact—driven entirely by magnetic interactions. As two magnetic layers slide, their internal forces compete, causing constant rearrangements that dramatically increase resistance at certain distances. This creates a surprising peak in friction instead of a steady rise, breaking a long-standing physics law.

sciencedaily.com logo
Mar 21 • 8:00 PM EDT • Science • sciencedaily.com
‘They want to colonise us’: Brazil’s Lula warns of foreign interference

The left-wing Brazilian president is critical of US actions throughout Latin America, though he does not name Trump.

aljazeera.com logo
Mar 21 • 7:35 PM EDT • Politics • aljazeera.com
March heat wave draws Coloradans to the water, boosts seasonal business

A historic March heat wave sweeping across Colorado is sending residents outdoors in search of relief, with many trading winter sports for time on the water.

kdvr.com logo
Mar 21 • 7:19 PM EDT • Business • kdvr.com
Trump continues to target Robert Mueller after his death

Mueller, who led the Russia investigation and the bureau after 9/11, remained a target of Trump years after his probe of possible election interference.

washingtonpost.com logo
Mar 21 • 6:05 PM EDT • Politics • washingtonpost.com
Robert Mueller, ex-FBI director at center of political tempest, dies at 81

After building a reputation for quiet rectitude, he became a political target as special counsel investigating Russian interference in the 2016 election.

washingtonpost.com logo
Mar 21 • 1:48 PM EDT • Politics • washingtonpost.com
Former FBI chief, Robert Mueller, dead at 81

Robert Mueller oversaw the probe into alleged Russian interference in the 2016 United States election.

aljazeera.com logo
Mar 21 • 1:42 PM EDT • Politics • aljazeera.com
Robert S. Mueller III, 81, Dies; Rebuilt F.B.I. and Led Trump Inquiry

After he concluded that Russia had interfered in the 2016 election, he became a target of the president’s anger.

nytimes.com logo
Mar 21 • 1:30 PM EDT • Politics • nytimes.com
Fed’s Powell Lauds Volcker Record in Face of Political Pressure

Federal Reserve Chair Jerome Powell on Saturday lauded the policy record of the late Fed Chair Paul Volcker, who raised interest rates and sparked a recession to tame the high inflation that took off during the 1970s.

bloomberg.com logo
Mar 21 • 1:30 PM EDT • Politics • bloomberg.com
Farmers and rural community members can access free mental health resources

KGAN CBS 2 and KFXA Fox 28 provide local news, weather forecasts, notices of events and items of interest in the community, sports and entertainment programming for Cedar Rapids and nearby towns and communities in the Corridor and throughout eastern Iowa, including Iowa City, Waterloo, Dubuque, North Liberty, Coralville, Marion, Morengo, Williamsburg, Washington, Tiffin, Tipton, Solon, Mount Vernon, Lisbon, Central City, Urbana, Independence, Manchester, Dyersville, Oelwein, Cedar Falls, Waverly, Evansdale, Guttenberg, West Union, New Hampton, Decorah, Waukon, Maquoketa, Sigourney, Fairfield, Grundy Center, La Porte City, Dysart, Fayette, Elkader, Strawberry Point and Belle Plaine.

cbs2iowa.com logo
Mar 21 • 12:14 PM EDT • Health • cbs2iowa.com
Particle Breakthrough: South Dakota scientists help unlock new neutrino mystery

Scientists at South Dakota Mines help achieve the first-ever measurement of a rare neutrino interaction, advancing physics and supporting future research at SURF.

kotatv.com logo
Mar 21 • 12:00 PM EDT • Science • kotatv.com
DNA building blocks on asteroid Ryugu, bacteria that eat plastic waste, and more science news

Catch up on some of the most interesting science stories from this week.

engadget.com logo
Mar 21 • 11:00 AM EDT • Science • engadget.com