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LA County Public Health confirms another case of measles
LA County Public Health said the traveler arrived in Southern California on July 3, 2026, aboard British Airways Flight 281, which landed at LAX. The person walked through Terminal B, Gate 155.
Rochester seeks developers for last vacant Science Park sites
Rochester is seeking developers for two vacant Science Park parcels near CityGate and UR, targeting research, office and manufacturing projects.
Science on Target: Q2 Research Cores Update
Use the below jump links to navigate to each Research Core update. Postmortem Tissue (PMT) Core Longitudinal Biofluid Core Data Engine Stem Cell Core Postmortem Tissue (PMT) Core The Target ALS Postmortem Core has now collected 650 cases, making it the most comprehensive ALS tissue repository worldwide that is accessible with no-strings-attached to the global […]
Platner’s campaign working to navigate exit from consequential Maine race, sources say
Graham Platner and a small team of strategists behind his candidacy are trying to navigate an exit from the consequential Senate race in Maine without entirely squandering the movement he built, people familiar with the matter said, rather than digging in or trying to find a path forward for his candidacy.
Watchdog calls for feds to investigate St. Louis County health director
The Holy Joe Society asserts that county health Director Dr. Kanika Cunningham has interfered in the board's operations, and is usurping the board's authority.
Teton Science School, Indian Springs Ranch to get county funding to design tunnel
Teton County commissioners reserved $65,000 in their budget to take early steps to ease harrowing left turns out of the Teton Science School and gated Indian Springs Ranch subdivision on to Highway 22.
Partnership leads to healthier moms and babies, building stronger families
In six rural counties across Indiana, Indiana University Health nurses works with families to navigate maternal and infant health
Attorney discusses FBI's investigation into teenage client's science experiment
A family attorney assures the public that there are no concerns necessary after the FBI investigated a teenager after a science experiment. Darsha Philips reports for the NBC4 News at 11 p.m. on Tuesday, July 7, 2026.
Kotsay on A's Misplay vs. Tigers, Ginn Injury Update
A blown call in shallow right field opened the floodgates in Detroit, while Ginn's illness-shortened start raised early concern before he exited
Judge Quashes Justice Dept. Subpoena in 2020 Election Inquiry
The ruling cast serious doubts on the department’s efforts to reinvestigate the race, finding that it was too late to bring criminal charges in the case.
‘Explosive Diarrhea’ Parasite Surges In Michigan, At Least 3 More States As Officials Investigate
Infections with cyclospora, a parasite that spreads through raw produce and causes severe “explosive” diarrhea, are on the rise in multiple states.
Make the Business Case for Your Sustainability Initiative
Sustainability proposals often stall not because they lack merit, but because they are framed in a language that does not match how senior leaders allocate capital. While CSOs tend to emphasize impact, materiality, and disclosure, CFOs and CEOs need to understand cash flow, risk, and return. External reporting frameworks are useful for accountability, but they are poorly suited to internal investment decisions, which require project-level comparisons rather than aggregated enterprise metrics. Sustainability investments should therefore be evaluated like any other investment: by showing how they reduce current costs, avoid future costs, generate new revenue, or protect existing revenue. Strong cases begin with a clear business story that links the proposed action to a specific business impact and cash-flow outcome, then quantify what can credibly be quantified while treating harder-to-measure benefits as either upside or an explicit strategic bet.
America’s small businesses are giving up on health insurance
America's employer-based health insurance system is crumbling. STAT investigates why, in our new series, “Out of Pocket, Out of Reach.”
America’s small businesses are giving up on health insurance
America's employer-based health insurance system is crumbling. STAT investigates why, in our new series, “Out of Pocket, Out of Reach.”
Labour asks Electoral Commission to investigate claims Farage broke electoral law by not disclosing gifts
Parliamentary authorities are already looking into a £5m donation to the Reform Uk leader from the crypto billionaire Christopher Harborne
Apple Intelligence Home Features Require 2TB iCloud+ Plan in iOS 27
Using Apple Intelligence camera features in the Home app will require an iCloud+ plan starting at 2TB, according to Apple. Apple shared the detail in its notes for the third macOS Golden Gate beta that was released today. In iOS 27, iPadOS 27, and macOS 27 Golden Gate, the Home app is able to generate written summaries for motion alerts from HomeKit Secure Video cameras.
Small Business Administration to help USDA sort 'lawfare' reports
John Rich says he’ll publicize cases of farmers being ‘shoved around’ The Small Business Administration agreed to help the USDA investigate complaints from farmers and ranchers who allege being victimized […]
Scientists solve a 30-year rye pollen mystery that could transform cancer research
Scientists have finally solved a nearly 30-year-old mystery surrounding two unusual molecules found in rye pollen that once showed an intriguing ability to help animals fight tumors. By determining their exact 3D structures, researchers have unlocked the blueprint needed to investigate how these natural compounds interact with the immune system and which parts may be responsible for their cancer-fighting effects.
'Yes, this does suck': NYC health officials brace for new Medicaid work rules
The new city budget includes $3M for hiring community health workers to help people navigate the changes.
Hennessey's New Hypercar Packs Over 2,000 Horsepower And A Manual
The Venom F5-M debuts with 2,031 horsepower and a gated six-speed manual. Hell yeah.
Beetroot juice is trending – its benefits go beyond the hype
Some marathon runners and other athletes swear by beetroot juice shots, but is there evidence they really do anything for our bodies? Columnist Alice Klein investigates
Families flee gunfire at Westgate Entertainment District
Five teens were hospitalized after being shot at Westgate Entertainment District in Glendale on July Fourth.
Families flee gunfire at Westgate Entertainment District; 5 teens shot
Five teenagers were shot at Westgate Entertainment District on Saturday night, and the teenage suspect remains at large, according to Glendale police.
NYC axes new rule on roll-down gates for businesses – after retailers already spent thousands
City lawmakers rolled back an obscure, decades-old law about storefront roll-down gates ahead of a looming enforcement deadline – but not before some retailers shelled out thousands of dollars in...
She navigated the US alone. Now, a UNT Health Fort Worth strategist guides others
Annabel Luna-Smith turned her own immigrant experience from Venezuela into work connecting residents to care and support.
Large fire erupts at business in Harbor Gateway, filling the air with black smoke
Firefighters moved into defensive positions as the fire burned out of control on Figueroa Street near Rosecrans Avenue and the 110 Freeway.
Mulitiple injured in Glendale shooting on Fourth of July
Several people were left injured on the Fourth of July Saturday night after a shooting at the Westgate Entertainment District in Glendale, authorities said.
Multiple people shot at Glendale's Westgate Entertainment District: PD
Police say multiple people were shot on July 4 at the Westgate Entertainment District in Glendale, and no suspects are in custody.
5 minors hurt after shooting at Westgate Entertainment District, police say
No suspect or suspects have been caught, police said.
‘Multiple victims’ in shooting at Westgate Entertainment District, police say
Officers are still working an active scene, officials said.
‘Multiple victims’ in shooting at Westgate Entertainment District, police say
Officers are still working an active scene, officials said.
A safe return home: Tackling stigma on Uganda's Ebola frontline
As Uganda works to contain an Ebola outbreak that is also affecting neighbouring Democratic Republic of the Congo (DRC), health workers are doing more than responding to a deadly virus. They are helping families navigate fear, misinformation and stigma.
Author, mental health advocate Kendall Concini-Moore creates experiences, not just books
“The Cloudy Day Chronicles” picture book series helps parents navigate tough feelings with their children while providing resources to help the conversation continue.
In an era of charged politics, teachers help their students navigate the maze of history
This year marks the 250th anniversary of the signing of the Declaration of Independence. The milestone coincides with an era when the historical record is a source of contention.
What to know about cyclosporiasis as Michigan health officials investigate 300+ cases in outbreak
Over 300 cases of cyclosporiasis have been reported within a week in Southeast Michigan, and Michigan health officials are investigating.
His AI startup has a literal moat: a castle for an office
Rémi Louf is the CEO of the AI startup .txt. He works out of a castle with iron gates and a moat in Bourron-Marlotte, France.
Declaration of Independence sets 'America apart from everybody else'
Oakland County Circuit Judge Michael Warren explains why the Declaration of Independence makes the USA so unique in world history.
CDC investigates parasite that’s caused cases of ‘explosive’ diarrhea in 18 US states
Parasite cyclospora spreads through produce and water contaminated with feces and causes the intestinal illness cyclosporiasis
Two stricken with Legionnaires Disease on Upper East Side, cluster investigated: NYC health officials
The patients were found in the Yorkville and Carnegie Hill neighborhoods of the Upper East Side, in zip codes 10028 and 10128, city officials said.
Gov. Jeff Landry says he will ask State Police to investigate after Liz Murrill’s indictment
Gov. Jeff Landry said he would have State Police investigate the proceedings and those who led them.
Supreme Court declines to halt daily $800 fine for ex-Fox News reporter refusing to divulge sources
The Supreme Court on Thursday declined to intervene after a judge ordered an $800-a-day fine for Catherine Herridge, a former Fox News reporter, if she refuses to reveal her confidential source for stories about a Chinese American scientist who was investigated by the FBI but never charged.
Scientists Thought Ravens Followed Wolves for Food. They Were Wrong. Ravens Predict Them
New GPS tracking suggests ravens navigate Yellowstone using a mental map of wolf kills.
Mystery parasite leaves Americans battling ‘explosive diarrhea’ as CDC investigates
The CDC reports 145 confirmed cyclosporiasis cases across 17 states as the parasitic outbreak season climbs, with 20 patients hospitalized so far.
What Makes Live Nation Entertainment (LYV) a Good Investment Bet?
TimesSquare Capital Management, an equity investment management company, released its “U.S. Mid Cap Growth Strategy” first-quarter 2026 investor letter. A copy of the letter can be downloaded here. The Strategy fell 7.72% (net) in the quarter compared to -6.35% for the Russell Midcap Growth Index. In the first quarter, markets navigated geopolitical tensions and economic resilience alongside […]
What is cyclosporiasis? Know the signs, prevention as Michigan health officials investigate outbreak
Michigan health officials are investigating an outbreak of cyclosporiasis across the state after at least 170 cases were reported within days.
Healthy Returns: Walmart, CVS step in to help seniors navigate Medicare coverage of obesity drugs
Medicare has started covering obesity drugs for the first time – and companies like Walmart and CVS Health are playing an important role for patients.
New details emerge on Xbox 'Positron', Microsoft's disc-to-digital program — as it seems likely Xbox Helix will drop discs too
Xbox Helix is likely to be joining PlayStation 5 in dropping discs. A new report describes how Microsoft plans to mitigate the issue.
Protecting Science. Advancing HIV Prevention. Preparing for What's Next
Global health is being reshaped by rapid geopolitical shifts, scientific breakthroughs and the growing role of artificial intelligence — creating both new opportunities and new challenges. Translating scientific breakthroughs into impact requires protecting research, advancing equitable access and ensuring communities are at the center. Explore AVAC’s latest resources to help navigate and shape what comes […]
Scientists recreated a dinosaur nest and solved a 70-million-year-old mystery
A team of researchers recreated a life-size oviraptor nest to investigate how these bird-like dinosaurs incubated their eggs millions of years ago. By combining physical experiments with heat transfer simulations, they discovered that oviraptors likely relied on both their own body heat and warmth from the sun.
Claude Helped a Hacker Find a Way to Issue Tickets to Almost Every US Music Festival
A researcher found that using Anthropic’s Claude Opus 4.7, he could break into the website of Front Gate—used by every festival from Lollapalooza to Bonnaroo—and freely issue any ticket he chose.
Miami Dolphins Discussion: 2026 NFL Schedule Edition
As the Miami Dolphins enter another season under a new regime and navigate significant roster changes, there is a palpable sense of uncertainty surrounding the team. Like many of you, however, I am eager to see how the squad performs once the regular season begins. Miami faces a challenging road ahead, as the team is […]
Supreme Court strikes down Watergate-era limits on campaign funds for political parties
The Supreme Court ruled again that campaign funding is free speech protected by the 1st Amendment.
Rethinking “Soft” Leadership Skills in Public Health
Learn how public health leaders can leverage interpersonal skills to better navigate cross-sector partnerships in this blog post.
Supreme Court Strikes Down Limits on Political Party Spending
At issue in the case was a post-Watergate law that Congress passed to limit the amount of money individuals can give to political parties.
Supreme Court scraps check on money in politics at request of Vance, GOP
The GOP asked the Supreme Court to scrap a Watergate-era rule preventing donors from bypassing limits on what they can give federal candidates.
Supreme Court lifts Watergate-era caps on campaign spending
The Supreme Court on Tuesday lifted a Watergate-era cap on how much money political parties may spend in coordination with candidates, siding with Republicans in a case initially filed by then-Senate candidate JD Vance that experts say could ultimately benefit the GOP in this year’s midterm election.
Six Terps Earn Preseason All-Big Ten Recognition from Athlon Sports
Six Maryland football student-athletes have been recognized on the Athlon Sports Preseason All-Big Ten Team, led by first-team selections Daniel Wingate and ...
"We're talking about at least half a decade of horror": former Exodus lead explains why he wasn't keen on doing a Baldur's Gate 4 despite Hasbro offering the chance
After Larian opted against a Baldur's Gate 4, Hasbro asked Archetype Entertainment head James Ohlen if he fancied a crack at it and he wasn't keen.
‘That would be insanity’: Baldur’s Gate 2 lead says he turned down Hasbro’s request to make Baldur’s Gate 4
Baldur’s Gate 2 developers declined a request to make a sequel to Larian’s third entry…
Recently acquired radiology group reports data breach
The Women’s Center for Radiology, which was acquired by Solis Mammography in January, hired a cybersecurity firm to help investigate the scope of the matter.
Health officials investigate cyclosporiasis cases in Monroe County, Michigan
Exclusive | Warren Buffett Skips Midyear Donation to Gates Foundation Amid Epstein Review
The billionaire is expected to delay a decision on his “lifetime” pledge until he see the results of the Gates Foundation’s review.
Police investigate vandalism at Youngstown business
According to a report, officers were called around 5:15 p.m. Sunday to a business on Dogwood Lane, where Youngstown Fire Department crews were already on scene.
Alachua police investigate suspicious package near business
Alachua County Sheriff’s Office bomb squad requested to assist.
OpenAI sets up 'warroom' to fix Codex limit issues
OpenAI investigates Codex's usage limit depletion that's impacting some users. The company has reset user caps to address the problem.
World Cup 2026 exit leaves South Korean football in crisis
After crashing out of the World Cup, BBC Sport investigates the rise and fall of South Korean football.
Comedian Bill Maher wins Twain humor prize as the Kennedy Center navigates Trump-era upheaval
Comedian Bill Maher is being awarded the prestigious Mark Twain Prize for American Humor. The ceremony is happening at the Kennedy Center, which has been embroiled in controversy. President Donald
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
State Sen. Josh Becker unveils "Wartime Price Gouging Prevention Act"
California Sen. Josh Becker has introduced a bill to empower the state attorney general to investigate price gouging during wartime emergencies, addressing what he says is a significant financial burden on Californians.
Humor laurels for comedian Bill Maher as the Kennedy Center navigates Trump-era upheaval
Comedian Bill Maher is set to receive the Mark Twain Prize for American Humor at the Kennedy Center.
Humor laurels for comedian Bill Maher as the Kennedy Center navigates Trump-era upheaval
Comedian Bill Maher is set to receive the Mark Twain Prize for American Humor at the Kennedy Center.
Humor laurels for comedian Bill Maher as the Kennedy Center navigates Trump-era upheaval
Comedian Bill Maher is set to receive the Mark Twain Prize for American Humor at the Kennedy Center.
Humor laurels for comedian Bill Maher as the Kennedy Center navigates Trump-era upheaval
Comedian Bill Maher is set to receive the Mark Twain Prize for American Humor at the Kennedy Center.
Arizona health officials investigate suspected pneumonic plague case
Health officials in Yavapai County are looking into a suspected case of pneumonic plague.
Standing Committee recommends adoption of four new business items, discusses relationship of the Church of the Brethren and Eder Financial
The Standing Committee of district delegates to the Church of the Brethren Annual Conference held meetings from Thursday evening, June 25, through Saturday afternoon, June 27, in Fort Wayne, Ind. Annual Conference moderator Don Fitzkee presided, assisted by moderator-elect Dennis Beckner and Conference secretary David Shumate.
Arizona health officials investigate suspected pneumonic plague case
Yavapai County Community Health Services said Friday that a county resident is thought to have contracted the infection.
Riding Into 2028: On the Midterms Trail, Andy Beshear Eyes a Bigger Prize
The two-term Democratic governor of deep-red Kentucky, in demand as a surrogate in key 2026 races, talks horses, faith and family politics as he considers a run for the White House.
‘A total fairytale’: Former Watergate prosecutor reacts to Vance’s comments on the scandal
Pete Buttigieg says he was the victim of bogus report to child protective services
The high-profile Democrat and potential 2028 presidential contender said he couldn’t see his twins for 24 hours as report was investigated.
Tom Hardy is dropping a rap album amid his uncertain future on 'MobLand'
As Tom Hardy navigates rumors of his 'MobLand' exit, he's stepped into the studio to release his first rap album.
How SBT navigated the politics of GRVL
Real community engagement and substantive changes paved the way for SBT GRVL's continued success.
The Best Prime Day SSD and HDD Deals Are Almost Gone: Save Big With Drives From Samsung, Seagate, WD, and More
After months of RAM-related price hikes, Amazon Prime Day is the best time to score deep discounts on SSDs and hard drives. But today is your last chance!
Vance Downplays Watergate and Compares Himself to Nixon
The vice president said that the scandal that ended Richard Nixon’s presidency would be “like a 12-hour news story” if it happened today and that the “deep state” had taken down Nixon.
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
Phoebe Gates' startup advertises Series A on bodega in NYC
There's a Coachella-like ad in NYC for the Series A round raised by Phoebe Gates' startup, Phia. It's a wall of celeb-investor names.
Vance dismisses Watergate scandal, says ‘deep state’ went after Nixon
The vice president said he admired Nixon and drew parallels between the past president, who resigned amid pressure in 1974, and Trump today.
JD Vance says Nixon’s Watergate scandal would be ‘12-hour news story’ today
Vice-president declares admiration for 37th president and claims Nixon and Trump targeted by ‘deep state’ forces
Vance, an admirer of Richard Nixon, says Watergate would be 'a 12-hour news story' today
Vice President JD Vance says the Watergate scandal that brought down President Richard Nixon would have been a blip in today’s news cycle
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
State health officials investigate Novi death, illnesses after dialysis
Police say no evidence of foul play in death, sicknesses following dialysis at DaVita.
Brad Stevens discusses ‘excitement’ surrounding Chris Cenac Jr.
“I hope we’re good enough that it’s hard for any 18-year-old or 19-year-old to come in here and be really good out of the gate.”
Another look at carrots and eyesight; how to get more fiber; why mosquitoes bite some people and not others; plus other stories with Vanderbilt Health sources
AARP reporter Stacey Colino interviewed Milam Brantley, MD, Associate Professor of Ophthalmology and Visual Sciences, in 2020 for a story about whether eating carrots can improve vision. Sacramento Bee reporter Samantha Agate has now used Brantley’s comments in an AI-curated story created by content specialists on the same topic that has been picked up by MSN and others. Prevention magazine interviewed Heidi Silver, RD, PhD, Founding Director of the Vanderbilt Diet, Body Composition, and Human Metabolism Core, for a story about the importance of fiber and how people can get more of it in their diet. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Women’s Health (tick bites and alpha-gal syndrome); The Washington Post (tetanus); and Healthline (why mosquitoes prefer to bite some people and leave others alone). A visit to Monroe Carell Jr. Children’s Hospital at Vanderbilt by some Banana Ball baseball players was covered by The Tennessean and WZTV Fox 17 News, and The Tennessean’s story was also picked up by Yahoo! Sports. Clarksville Now published a story written by the Montgomery County Economic Development Team, whointerviewed Bradley Stancombe, MD, professor of Clinical Pediatrics, Vanderbilt Neonatology, about the new energy of Vanderbilt Clarksville Hospital and how the facility is recruiting physicians. Healio Allergy/Asthma group editorial director Richard Gawel interviewed Mark Rolfsen, MD, Clinical Fellow in the Division of Allergy, Pulmonary and Critical Care Medicine, for a story about his presentation at the American Thoracic Society meeting on metal health outcomes following ICU discharge. Nashville Scene reporter Hannah Herner interviewed James Crowe, MD, Director of the Vanderbilt Center for Antibody Therapeutics, for a story about his efforts to prepare for the next pandemic by isolating antibodies that can neutralize dangerous viruses. Medscape reporter Kathleen Doheny interviewed Neesha Choma, Associate Chief of Staff of Vanderbilt University Hospital, for a story about how hospitals can reduce readmissions.
AMC Entertainment Holdings, Inc. Announces Closing of $200 Million Registered Direct Offering of Common Stock
LEAWOOD, Kan., June 25, 2026--AMC Entertainment Holdings, Inc. (NYSE: AMC) ("AMC" or "the Company"), announced today that it closed its previously announced registered direct offering of an aggregate of 95,250,000 shares of AMC common stock for gross proceeds of approximately $200 million (the "Offering"), before deducting agent fees and offering expenses.
Who gets to decide Colorado’s economic future?
By Sarah Blackhurst Colorado’s prosperity depends on industries that grow our food, build our future and power our homes. But today, these sectors face an invisible threat from 5,000 miles away: the European Union’s Corporate Sustainability Due Diligence Directive (CS3D). This foreign regulation requires companies to mitigate environmental and human-rights effects throughout their entire global […]
Department of Education investigates Maryland schools over boys access to girls sports and facilities
The U.S. Department of Education has launched an investigation into Maryland's Department of Education and three public School districts, claiming that boys are joining girls athletic teams and accessing girls facilities.
Mercy Helps Position St. Louis as Global Gateway for Healthcare Innovation
Mercy continues to bring innovative thought leadership to the communities it serves and beyond. Dr. Damon Broyles, Mercy vice president of clinical innovation, informatics and precision medicine, recently shared insights and helped attract new companies to St. Louis’ nationally recognized healthcare industry as part of BioSTL.
New Patient Guidebook Helps Puget Sound Beneficiaries Navigate Their Health Care
MADIGAN ARMY MEDICAL CENTER, Joint Base Lewis-McChord, Wash. -- Great news for military communities and TRICARE beneficiaries across the Pacific Northwe...
Police investigate after protests at skincare business
Accused of aggression, skincare sellers at center of demonstration, town ordinance, allege antisemitism.