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One of Earth’s most explosive supervolcanoes is recharging
Far beneath the ocean near Japan, scientists have discovered that the magma system linked to the most powerful eruption of the Holocene is slowly rebuilding. By using seismic imaging, researchers mapped a large magma reservoir under the Kikai caldera and confirmed it is the same system that fueled the massive eruption 7,300 years ago. However, the magma now present is newly injected, not leftover, as shown by changes in the chemistry of recent volcanic material and the growth of a lava dome over thousands of years.
Researcher Shows Anxiety Could Be Linked to a Nutritional Deficiency
Research shows that people with anxiety disorders had significantly lower choline levels in their brain tissue.
What teens eat could be affecting their mental health more than we thought
What teens eat might matter more for their mental health than previously thought. A sweeping review of nearly 20 studies found that healthier diets are often linked to fewer depressive symptoms, while poor eating habits may go hand in hand with greater psychological distress. Interestingly, focusing on whole dietary patterns—not just individual nutrients—showed more consistent benefits, suggesting that overall eating habits could play a meaningful role during this critical stage of brain development.
What teens eat could be affecting their mental health more than we thought
What teens eat might matter more for their mental health than previously thought. A sweeping review of nearly 20 studies found that healthier diets are often linked to fewer depressive symptoms, while poor eating habits may go hand in hand with greater psychological distress. Interestingly, focusing on whole dietary patterns—not just individual nutrients—showed more consistent benefits, suggesting that overall eating habits could play a meaningful role during this critical stage of brain development.
To protect public health, California must embrace clean transportation
“Diesel pollution is linked to asthma, heart disease, lung cancer, premature death and harm to children’s developing lungs and brains.”
Lewis Steele reveals Liverpool’s top target to replace Mohamed Salah
Liverpool Transfer News: Yan Diomande Heavily LinkedIn the latest Media Matters episode from Anfield Index, Dave Davis and Lewis Steele explored Liverpool’s forward planning, with Yan Diomande among...
Popular sugar substitute linked to brain damage and stroke risk
A widely used sugar substitute found in everything from keto snacks to diet drinks may not be as harmless as it seems. New research shows that erythritol can disrupt brain blood vessel cells, reducing their ability to relax, increasing harmful oxidative stress, and impairing the body’s ability to break down clots. These changes create conditions that could raise stroke risk, even at typical consumption levels.
One type of alcoholic drink linked to lower death risk, study finds
While experts advise avoiding alcohol altogether, a new study says that, among those who imbibe a low or moderate amount, there is a decrease in serious health risks and one type of alcoholic drink…
Sports Betting Linked to Rising Credit Card and Auto Loan Delinquencies
A new Fed study finds that the expansion of legal betting is driving declines in household financial stability, particularly among younger consumers.
Iran-linked hackers have breached FBI Director Kash Patel’s personal emails
Hackers connected to the Iranian government accessed FBI Director Kash Patel’s personal email and posted materials — including photos and documents — taken from his account, a person familiar with the hack confirmed to CNN.
Your stereotypes about Gen Z aren’t just inaccurate. They’re hurting your business
Welcome to Fast Company Daily, our daily newsletter on LinkedIn, featuring a free article selected each day by our editors as well as a roundup of great advice on careers, hiring, innovation, and technology. Visit fastcompany.
AitM Phishing Targets TikTok Business Accounts Using Cloudflare Turnstile Evasion
AitM phishing hijacks TikTok Business accounts via Cloudflare Turnstile evasion as SVG malware linked to BianLian targets Venezuela.
Health Rounds: Researchers find biomarker that could lead to improved schizophrenia treatments
Researchers have identified a biomarker linked to schizophrenia that could lead to new treatments to tackle symptoms of the debilitating mental disorder not addressed by current medicines.
Italian regulator launches probe into LVMH, Sephora for unfair commercial practices
The Italian competition authority AGCM said on Friday it had launched two investigations into LVMH-owned entities in Italy, citing unfair commercial practices linked to the premature use of adult cosmetics among minors.
Measles case confirmed in Multnomah County linked to Gresham WinCo exposure
Multnomah County health officials are investigating one confirmed case of measles linked to a known exposure site at a WinCo grocery store in Gresham.
One type of alcoholic drink linked to lower death risk, study finds
While experts advise avoiding alcohol altogether, a new study says that, among those who imbibe a low or moderate amount, there is a decrease in serious health risks and one type of alcoholic drink…
Partnership in Action: Reimagining Climate and Health Funding Together
Climate Communities Network members explore funding strategies to sustain community-based climate and health work amid shifting challenges.
‘Hard to say no’ – Jan Virgili talks possible Barcelona return
The winger has been linked with a summer return.
Scientists discover why this deadly lung cancer keeps coming back
Scientists have discovered that losing a key protein in small cell lung cancer triggers inflammation that actually helps tumors grow and spread. Even more surprising, it pushes cancer cells into a more aggressive, neuron-like state linked to relapse.
Trump touts ‘significant’ Iran ‘present’ linked to Strait of Hormuz as deal talks heat up
President Donald Trump said Iran gave the U.S. a 'significant' oil and gas gift tied to the Strait of Hormuz, saying Iran is ready to make a deal on nuclear weapons.
Subtle health changes may signal progressive supranuclear palsy years in advance
Drawing from UK Biobank data, Mass General Brigham researchers have uncovered specific health factors linked to higher or lower risk of developing progressive supranuclear palsy (PSP), a rare but devastating ...
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
Mediterranean diet may boost mitochondrial signals linked to heart and brain health
A study led by researchers at the USC Leonard Davis School of Gerontology suggests that the benefits of the Mediterranean diet may be driven, in part, by tiny proteins hidden within our mitochondria, ...
Diabetes, Overlooked and Unchecked, Poses New Risks in Africa
As deaths from diabetes start to rival those from infectious threats like malaria, a new form of the condition linked to malnutrition is surfacing in patients who can afford neither screening nor care.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Chiefs’ 2026 NFL Mock Draft roundup after NFL Free Agency
A closer look at the Chiefs’ 2026 mock draft outlook after free agency, with linked to edge help, cornerback, and offensive line support.
Colorado lawmakers can pass “Alyssa’s Act” to help coaches and parents monitor mental health (Opinion)
In 2019, we lost Alyssa after she struggled with her mental health following a series of concussions. We later learned that concussions can be linked to serious mental health challenges and an increase in suicide, especially in young people.
Brain’s protective barrier stays leaky for years after playing contact sports
Damage to the blood-brain barrier is linked to immune changes and cognitive decline
Early Menopause Linked to 40% Higher Risk of Cardiovascular Disease
Women who go through natural menopause before age 40 face a 40% higher lifetime risk of coronary heart disease. Black women are three times as likely to experience early menopause as white women.
Wine vs beer vs spirits: Which is the least bad for your health?
A study of 340,000 adults suggests not all alcohol carries the same risk - even at low to moderate levels, beer, cider and spirits were linked to higher mortality, while wine was associated with a lower risk.
Feds launch probe to unravel alleged nonprofit funding behind Antifa-linked violence
The DOJ, FBI and IRS are investigating nonprofit groups the Trump administration says are funding political violence, under a directive known as NSPM-7.
Men are losing a key chromosome with age and it may be deadly
Aging men often lose the Y chromosome in a growing number of their cells—and it may be far more dangerous than once believed. This loss has been linked to heart disease, cancer, Alzheimer’s, and shorter lifespans. Researchers suspect Y-less cells may grow faster and disrupt normal body functions. What seemed like a minor genetic quirk could actually be a major driver of age-related disease.
Michigan declares 1st measles outbreak as cases spread 'like wildfire'
All three measles cases reported in March in Michigan are linked to a person in Washtenaw County who likely contracted it on a trip to Florida.
How Stress, Depression and Anxiety Hit the Heart
Depression, anxiety, PTSD and more are linked to higher odds of heart attack, stroke and heart failure — and the risk is especially relevant after age 50
Ozempic Linked to Lower Risk of Plunging Mental Health in Study
Swedish people with depression and anxiety who took Novo Nordisk A/S’s blockbuster shots Ozempic and Wegovy were less likely to see their mental health get worse, the latest data to suggest that popular diabetes and obesity drugs could also have a broader impact on well-being.
Across the globe, forgiveness is linked with well-being | Harvard T.H. Chan School of Public Health
Practicing forgiveness may lead to higher well-being over time, according to a new multinational study led by researchers from Harvard Chan School and Harvard’s Human Flourishing Program.
LinkedIn partners with The Trade Desk for CTV ads
LinkedIn wants a bigger chunk of the streaming TV ad business. The Trade Desk will be its first demand-side platform partner for connected-TV ads.
9 Fruits To Reduce Inflammation In The Body
Fruits are one of the best sources of anti-inflammatory nutrients, helping to reduce chronic inflammation, which has been linked to heart disease, cancer and cognitive decline.
Nasal Swab Test Spots Early Alzheimer’s Signals
DURHAM, N.C. – Alzheimer’s disease affects millions of people worldwide, yet the illness is hardest to catch at the very beginning, when new treatments may work best.In a new study, Duke Health researchers show that a quick, outpatient nasal swab can pick up early biological changes linked to Alzheimer’s, even before thinking and memory problems appear.
Your daily coffee may be protecting your brain, 43-year study finds
Your morning coffee or tea could be quietly supporting your brain health. A long-term study found that moderate consumption of caffeinated coffee or tea was linked to an 18% lower risk of dementia and better cognitive performance over time. The benefits appeared strongest at 2–3 cups of coffee or 1–2 cups of tea daily—and even held true for people genetically predisposed to dementia.
Health officials urge consumers to avoid raw cheddar tied to ongoing E. coli outbreak
L.A. County health officials are urging consumers not to eat Raw Farm-branded raw cheddar cheese after the product was linked to an ongoing outbreak of Shiga toxin‑producing E. coli. This type of b…
E. coli outbreak linked to raw cheddar cheese allegedly sickens 7 people across multiple states
E. coli outbreak allegedly linked to raw cheddar cheese affects 7 people across California, Texas and Florida, with most victims under 3 years old.
Two dead, 11 others infected in meningitis outbreak linked to English university
Two young people have died amid an outbreak of invasive meningococcal disease in southern England, with 11 other cases also confirmed.
Health officials investigate E. coli outbreak linked to raw cheese sold in Florida
Health officials are investigating an outbreak of E. coli in multiple states, including Florida, that appears to be linked to raw cheese products.
Scientists discover ALS protein that links DNA repair to cancer and dementia
A protein tied to ALS and dementia may have a much bigger role in disease than scientists realized. Researchers found that TDP43 controls a key DNA repair process, but when the protein becomes imbalanced, the repair system can spiral out of control, harming neurons and destabilizing DNA. The team also discovered that high levels of the protein are linked to increased mutation rates in cancer. The discovery places TDP43 at the center of both neurodegeneration and cancer biology.
Teenagers Have Easy Access to Weed. Science Says It’s Bad for Them.
New research shows even infrequent cannabis use during adolescence is linked to increased risk of mental-health disorders and poor academic performance.
Teenagers Have Easy Access to Weed. Science Says It’s Bad for Them.
New research shows even infrequent cannabis use during adolescence is linked to increased risk of mental-health disorders and poor academic performance.
Centuries-old skeletons reveal a hidden effect of tobacco no one had identified before - Futura-Sciences
It is no longer up for debate: tobacco use has devastating effects on human health. And even today, researchers continue to uncover new harmful consequences linked to it. A recent study conducted by researchers at the University of Leicester, published in the journal Science Advances, reveals a surprising discovery: tobacco...
Potential measles exposure linked to eastern Iowa hotel
The Illinois Department of Public Health notified Iowa HHS about an Illinois resident that tested positive for measles and traveled to Iowa while infectious.
New cholesterol guidelines released by the American Heart Association
Also, for the first time, doctors are advised to test for two biomarkers in the blood that have been linked to increased risks of heart disease.
The New CEO Of Acquisition.com: From Goldman To Building The ‘Disney Of Business’
Most Goldman Sachs bankers leave with a set of deal-structuring skills and a polished LinkedIn profile. Sharran Srivatsaa left with a lesson he learned at a closing dinner.
Should You Lower Your Bedroom Temperature for Better Heart Health?
New research suggests that higher bedroom temperatures may be linked to a higher heart rate and lower heart rate variability.
More Concussions Linked To Worse Brain Health Among Recent College Grads
By Dennis Thompson HealthDay ReporterTHURSDAY, March 12, 2026 (HealthDay News) — Former college athletes can show signs of concussion-related brain decline as early as five years after graduation, a new study says. Athletes who had three or more concussions during college play had worse scores on ...
Eating more ultra-processed foods linked to poorer bone health, study finds
From flavored yogurts to frozen pizzas, breakfast cereals and instant oats, ultra-processed foods are convenient, often cheaper items designed for a quick bite. In recent years, excess consumption of ...
WhatsApp is launching parent-linked accounts for pre-teens
WhatsApp is rolling out parent-managed accounts for under-13 users, limiting features to messaging and calls while giving parents PIN-protected controls, alerts, and approval over contacts and groups.
College Sports Commission's NIL clearinghouse strained by surge in school-linked deals
Deals tied to collectives and institutional partners are overwhelming the CSC and triggering growing legal and conference scrutiny
South Carolina measles outbreak nears 1,000 cases; most unvaccinated
The South Carolina Department of Public Health reported two new measles cases on Tuesday, bringing the total number of cases linked to the Upstate outbreak to 9
Reeves to face MPs’ grilling over cost-of-living pressures
Chancellor to take Treasury questions amid market turbulence linked to Middle East conflict
It was John Wayne’s political club. Now it’s spending millions on online influence
A foundation linked to the Lincoln Club started local news sites critics find dubious. How John Wayne's old group became major influencers.
How generational turnover and party switching reshape the US political map
Political polarisation has increased dramatically in the US in recent decades and is often linked to partisan geographic segregation. This column presents new evidence from 2008 to 2020 that reveals an increase in partisan segregation even at very local levels. However, while most studies focus on one explanatory factor, residential mobility, we find that generational change (in Democratic-trending areas) and Democrats leaving their party (in Republican-trending areas) explain a much larger share of the rise in partisan segregation.
Private jet used for Nigel Farage Chagos stunt linked to Reform mega-donor
Exclusive: Plane that flew Reform leader to Maldives appears to be linked to billionaire Christopher Harborne
AI discovers the hidden signal of liquid-like ion flow in solid-state batteries
Solid-state batteries could be safer and more energy-dense than today’s lithium-ion technology, but finding materials that allow ions to move quickly through solid electrolytes has been difficult. Researchers developed a machine learning pipeline that predicts Raman spectra and identifies a distinctive low-frequency signal linked to liquid-like ion motion inside crystals. This signal appears when rapid ion movement temporarily disrupts a crystal’s symmetry. The approach could dramatically speed up the discovery of superionic materials for advanced batteries.
Consumer Reports warns some personal product ingredients may pose health risks
PFAS, also known as "forever chemicals," can show up in waterproof or long-wear makeup and have been linked to serious health concerns.
Wildfire pollution linked to higher stroke risk
Ultra-processed diet and behavior, UnitedHealth's latest SEC filing, and other health news
Popular fruits and vegetables linked to higher pesticide levels
A sweeping new study reveals that what’s on your plate may directly shape the pesticides circulating in your body. Researchers found that people who eat more fruits and vegetables known to carry higher pesticide residues—such as strawberries, spinach, and bell peppers—also have significantly higher levels of those chemicals in their urine. While produce remains a cornerstone of a healthy diet, the findings highlight how everyday food choices can drive real-world exposure to substances linked to cancer, hormone disruption, and developmental harm.
Trump says US will cut all trade with Spain over military bases, defence spending
U.S. President Donald Trump said on Tuesday the United States would cut off all trade with Spain after the European country refused to let the U.S. military use its bases for missions linked to strikes on Iran.
Brazil Gift Card Business Databook Report 2026: Market to Grow by Over $5.5 Billion by 2030 with Distribution Concentrating Around Large Retail Chains, Marketplaces, and Digital Platforms
The Brazilian gift card market presents opportunities in digital transformation, integration with payment ecosystems, use in corporate incentives, and strategic partnerships. Key areas include shifting to account-linked digital cards, embedding in digital wallets and payments, structured corporate use, and leveraging large retail platforms for distribution. Brazilian Gift Card Market Brazilian Gift Card Market Dublin, March 03, 2026 (GLOBE NEWSWIRE) -- The "Brazil Gift Card Business and Investme
Scientists just found the brain’s hidden defense against Alzheimer’s
A new study has uncovered why some brain cells are more resistant to Alzheimer’s damage than others. Researchers found a natural cleanup system that helps remove toxic tau protein before it can form harmful clumps. The study also shows that cellular stress can produce a dangerous tau fragment linked to Alzheimer’s. Strengthening the brain’s natural defenses could point the way to new treatments.
California measles outbreaks linked to pockets of unvaccinated residents
California health departments are fighting to contain measles outbreaks as cases rise and resources shrink. Investigating communicable diseases is time-intensive and expensive. Officials say teams have about 72 hours after a positive case to find exposed people and stop spread.
There’s a New Kyler Murray Report
As the offseason is slowly heating up, the Minnesota Vikings are linked to all kinds of quarterbacks. One of those […]
Common nighttime noise exposure may trigger heart problems, study suggests
European study of 272,000 adults finds nighttime traffic noise above 50 dB linked to higher cholesterol and increased heart disease risk. Researcher Yiyan He discusses.
Health officials confirm 2 measles cases linked to Mass.
The cases are the first two with ties to the state this year, but they come amid a large national outbreak.
Vegan diets linked to colon cancer in large new study: what to know
A new study suggests vegan diets may be lacking some nutrients that help shield people from colon cancer. Fortification could help.
Popular brain supplement linked to shorter lifespan in men
A massive study of more than 270,000 people has uncovered a surprising link between a common amino acid and how long men live. Researchers found that higher levels of tyrosine—an amino acid found in protein-rich foods and often marketed as a focus-boosting supplement—were associated with shorter life expectancy in men, potentially trimming nearly a year off lifespan.
Would you eat fruits and vegetables with a doctor’s prescription?
“These health issues are linked to what type of food we choose, with 80 to 90% of folks that don’t meet recommended dietary guidelines for fruit and vegetable consumption,” Song writes.…
Obesity is linked to 1 in 10 deaths from infection worldwide — and scientists are still learning why
A new study finds that people with obesity are more likely to be hospitalized with or die from severe infections.
Fact-check: Do chronic illnesses account for 90% of U.S. health care spending?
A federal government campaign that encourages Americans to avoid processed foods claims that "90% of U.S. healthcare spending goes to treating chronic disease — much of which is linked to diet and lifestyle."
A Woman Started Losing Her Sight Because of a Tattoo She Got Years Ago on Her Back. She's Not Alone
A rare inflammatory condition linked to tattoos is appearing more often in Australia.
Plasma proteomic profiles linked to suicidal behaviors
Nature Mental Health - Using plasma proteome profiles from over 53,000 UK Biobank participants, Zhang et al. examined proteins associated with suicidal behavior and investigated pathways that could...
“Celtic curse” hotspots found in Scotland and Ireland with 1 in 54 at risk
Researchers have mapped the genetic risk of hemochromatosis across the UK and Ireland for the first time, uncovering striking hotspots in north-west Ireland and the Outer Hebrides. In some regions, around one in 60 people carry the high-risk gene variant linked to iron overload. The condition can take decades to surface but may lead to liver cancer and arthritis if untreated.
Common pneumonia bacterium may fuel Alzheimer’s disease
A common bacterium best known for causing pneumonia and sinus infections may also play a surprising role in Alzheimer’s disease. Researchers found that Chlamydia pneumoniae can invade the retina and brain, where it sparks inflammation, nerve cell death, and the buildup of amyloid-beta—the hallmark protein linked to Alzheimer’s. Higher levels of the bacterium were found in people with Alzheimer’s, especially those carrying the high-risk APOE4 gene, and were tied to more severe cognitive decline.
Cristiano Ronaldo expands his business portfolio off the pitch
New move strengthens his long-standing business tiesCristiano Ronaldo expands his business portfolio off the pitchCristiano Ronaldo invested $7.5 million in Herbalife-linked tech company taking 10% st...
Blue Owl unable to arrange financing for a $4 billion data center
Blue Owl tried to line up debt for a Pennsylvania data center tied to CoreWeave, but lenders passed, underscoring growing caution around AI-linked credit.
What to know about the link between tattoo ink and cancer risk
Mounting evidence suggests tattoos are linked to elevated cancer risk.
The Moon is still shrinking and it could trigger more moonquakes
Researchers have uncovered more than a thousand previously unknown tectonic ridges across the Moon’s dark plains, showing the Moon is still contracting and reshaping itself. These features are among the youngest geological structures on the lunar surface. Because they form through the same forces linked to past moonquakes, they could signal new seismic hotspots.
French far-left political party linked to far-right activist's killing says office evacuated over bomb threat
The far-left France Unbowed party says it evacuated its Paris office due to a bomb threat as 2 more people were detained over the killing of a far-right activist.
‘This is not over.’ Corporate America’s Epstein reckoning gathers steam
A growing wave of business leaders has had their careers derailed after the recent release of millions of files linked to convicted sex offender Jeffrey Epstein.
South Florida leaders push crackdown on Cuba-linked firms, a lifeline for thousands of families
Miami-Dade and local leaders seek tougher action on Cuba trade, revoking licenses, urging federal probes and targeting flights, remittances and shipments.
Ice rink shooter's gender transition, mental health linked to family strife
Court documents reviewed by NewsCenter 5 reveal the ice rink shooting suspect's gender transition and mental illness were a long-running source of family strife.
Windows 11 KB5077181 fixes boot failures linked to failed updates
Microsoft says it has resolved a Windows 11 bug that caused some commercial systems to fail to boot with an "UNMOUNTABLE_BOOT_VOLUME" error after installing recent security updates, with the fix delivered in the February 2026 Patch Tuesday update.
Is Tinder the new LinkedIn? Job-hunters swipe for leads on dating apps
Looking for a job? These workers say dating apps like Tinder, Hinge, and Grindr may be your best bet for networking and seeking referrals.
Tech titans Elon Musk and Reid Hoffman attack each other over latest Epstein emails
Elon Musk and LinkedIn co-founder Reid Hoffman clash on social media over alleged Jeffrey Epstein connections, trading accusations and email screenshots.
Small Business Technology News: AI Models That Are Better Than ChatGPT
Intuit adds more AI for QuickBooks, LinkedIn does more for recruiting and a startup raises $25M to answer the calls you're missing.
Scientists discover a hidden gut bacterium linked to good health
A global study has uncovered a mysterious group of gut bacteria that shows up again and again in healthy people. Known as CAG-170, these microbes were found at lower levels in people with a range of chronic diseases. Genetic clues suggest they help digest food and support the broader gut ecosystem. Researchers say the discovery could reshape how we measure and maintain gut health.
Scientists discover a hidden gut bacterium linked to good health
A global study has uncovered a mysterious group of gut bacteria that shows up again and again in healthy people. Known as CAG-170, these microbes were found at lower levels in people with a range of chronic diseases. Genetic clues suggest they help digest food and support the broader gut ecosystem. Researchers say the discovery could reshape how we measure and maintain gut health.
NASA scientists say meteorites can’t explain mysterious organic compounds on Mars
Scientists studying a rock sample collected by NASA’s Curiosity rover have uncovered something tantalizing: the largest organic molecules ever detected on Mars. The compounds — decane, undecane, and dodecane — may be fragments of fatty acids, which on Earth are most often linked to life. While non-living processes like meteorite impacts can also create such molecules, researchers found those sources couldn’t fully explain the amounts detected.
Barron Trump linked to beverage company based near Mar-a-Lago
Barron Trump is listed in public records as a partner in a new yerba mate beverage startup called SOLLOS, raising $1 million through private placement.
UK public health system posts job ad for nurse focused on 'close-relative marriage'
UK health agency advertises nursing role for families in cousin marriages linked to higher genetic risks for children in controversial health program.