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Browns Week 7 inactives: Who's in, who's out?
The Browns are the healthiest they have been in some time as they take on the Titans in Week 7.
Blue Ivy takes the stage, Destiny’s Child reunites at Jay-Z’s L.A. concert
Blue Ivy Carter joined dad Jay-Z onstage for a piano accompaniment, while mom Beyoncé cheered her on with two very special guests.
Astros should stay away from these 2 free agent outfielders
Astros shouldn't be interested in these two outfielders.
Republican responds to AI video in Fort Bend County political battle
Fort Bend County has seen plenty of controversy at its highest levels.
Obama and Trump wage one last battle for even more urgent stakes
Two decades ago, Barack Obama stormed battleground states rebuking a Republican president over a deeply unpopular war and an economy that was crushing working Americans.
Chair of 'submarine affair' committee probing Netanyahu resigns due to health concerns
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Cost of employer-sponsored health insurance rises again, survey finds
WASHINGTON — The cost of employer-sponsored health insurance increased again this year, as did the deductibles many people must pay before their plans begin covering most health care expenses, according
How Braves should handle $42 million Jurickson Profar situation
This could be one solution for the Braves.
Packers Lose Defensive Captain Just Before Massive Showdown With Lions
Green Bay Packers defensive captain Zaire Franklin has been ruled out against the Detroit Lions, leaving Green Bay without both starting linebackers.
How Nathan Fielder's cringe-comedy career led him to Elizabeth Holmes
Spoiler alert! We're discussing the themes and structure of the Elizabeth Holmes documentary "You Can See Everything" and touching on a surprising aspect of its second half, so turn away if you want to go in completely cold.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Texas Tech Leads 'Bad' Week 8 for Big 12 Unbeatens
The Red Raiders’ playoff dreams hit a wall in Cincinnati as sloppy play and missed opportunities ended their unbeaten run. The Big 12 race is now more open than ever after surprising finishes elsewhere.
South Texas Health System (@stxhealthsystem)
1 likes, 1 comments - stxhealthsystem on October 25, 2026: "Exceptional Care Starts With You: Nurses play a vital role in every patient journey, providing the compassionate, skilled care that helps make South Texas Health System’s 12 facilities a trusted healthcare resource for communities across the Rio Grande Valley. If you're passionate about making a difference and delivering exceptional patient care, now is your opportunity to join the largest integrated healthcare network in the region. STHS is seeking dedicated and compassionate registered nurses to join its team at four acute care hospitals, a behavioral health hospital and seven freestanding emergency departments. Become part of a team committed to clinical excellence, collaboration and compassionate care. To view current openings and apply, visit the STHS careers page at the link in our bio.".
Robinson, Baker have tough talk about the offense
Robinson, Baker have tough talk about the offense
On Christ the King and the idolatry of politics
Editor’s note: This homily was preached on the feast of Christ the King (Extraordinary Form), October 25, 2026, at the Church of the Holy Innocents, New York City. In the calendar of the Usus Antiquior, […]
Seattle Mariners Rumors: Zach Neto Gaining Traction as Possible Target
The M's certainly have a need for what Neto can provide.
Wrexham’s Summer Striker Decision Faces Fresh Scrutiny After Blackburn Defeat
Wrexham’s decision to back their current centre-forwards has become a renewed talking point after Saturday’s 2–0 defeat at Blackburn Rovers exposed the gap between attacking activity and a meaningful goal threat.
Postpartum recovery window may play a critical role in maternal aging and long-term health
In many studies, it appears that women who have more children have a higher risk of heart disease and a shorter life span, but this effect is inconsistent across populations and no good explanation for ...
Stateliner Pride on Display: Phillipsburg Band and Alumni Unite at Halftime
Phillipsburg’s Stateliner band and alumni joined for a halftime performance celebrating school tradition, pride and community at Friday’s football game.
Campbell County health and food inspections (10/16/26–10/22/26)
GILLETTE, Wyo. — The Consumer Health Services Division of the Wyoming Department of Agriculture conducts inspections of retail food establishments throughout Wyoming (where there is not a local health department that does inspections) to help ensure safety of Wyoming residents. Campbell County establishments are inspected at least once a year by the WDA. All of […]
Laramie County health and food inspections (10/16/26–10/22/26)
CHEYENNE, Wyo. — The Cheyenne-Laramie County Health Department inspects restaurants, bars, convenience stores, delis, grocery stores, bed and breakfasts
Natrona County health and food inspections (10/16/26–10/22/26)
CASPER, Wyo. — The Casper-Natrona County Health Department inspects restaurants, grocery stores, convenience stores, mobile food units, commissaries and
Evaluating DJ Herz After Bouncing Back from Injury with Nationals
After making his first MLB appearance in nearly two years, what should the Washington Nationals expect from DJ Herz in his third season with the organization?
What Chelsea Did Wrong vs Tottenham
After a stellar run following the international break, things came crashing down for Chelsea as they lost 2-0 to Tottenham Hotspur at the weekend. This marked an extremely rare defeat at Stamford Bridge to the Lilywhites, a crack in a strong record of home wins that has left fans reeling. In this, we will be …
University of Rochester Medicine Home Healthcare holds inaugural Hospice 5K
13WHAM ABC Rochester provides local news, weather forecasts, traffic updates, health reports, notices of events and items of interest in the community, local sports and entertainment programming for Rochester and nearby towns and communities including Greece, Victor, Pittsford, Penfield, Henrietta, Webster, Irondequoit, Fairport, Chili, Gates, Rush, Wheatland, Canandaigua, Farmington, Spencerport and Hilton.
Grading Iowa Football's Loss To Minnesota
This may have been Iowa's worst quarterback performance since the dreadful 2023 season.
Mavericks 'Very, Very Confident' in Rookie PG Behind Kyrie Irving
Spanish sensation Sergio de Larrea shined with 21 points against San Antonio, proving he can anchor the rotation while Dallas carefully manages Kyrie Irving’s heavy workload.
NFL Trade Deadline Could Dramatically Change The AFC South Landscape
With top stars from the Titans, Colts, and Jaguars hitting the trade block, Houston’s rivals could strip their rosters of veteran talent to fuel a mid-season rebuild.
Arch Manning has another viral moment with ESPN's Holly Rowe
The Texas quarterback was happy to see Rowe on the sidelines.
Instacart Stock What Health Benefits Deal And $5 Million Settlement Mean
Instacart parent Maplebear has agreed to a US$5,000,000 settlement with U.S. authorities over past PERM hiring practices and has been selected by True Rx Health Strategists to power an employer funded healthy food benefit through Instacart Health Fresh Funds starting in 2027. The True Rx program positions Instacart within pharmacy benefit design and ties employer spend directly to clinically supervised food choices. The settlement adds compliance obligations, policy changes and monitoring...
After long, strange trip, Compass CEO nears launch of psilocybin pill
Compass Pathways is on the cusp of FDA approval for a proprietary version of psilocybin — the active drug in magic mushrooms.
Opinion - How Trump learned to stop worrying and love space science
He recognizes a cool thing when he sees it.
Nick Nurse: “Jaylen Brown is obviously very good. He …
Nick Nurse: “Jaylen Brown is obviously very good. He …
Evan Mobley on Jarrett Allen: “The team loves it. …
Evan Mobley on Jarrett Allen: “The team loves it. …
Khaman Maluach: “It’s different. Draymond Green is …
Khaman Maluach: “It’s different. Draymond Green is …
"I mean, stuff happens. It's a business. It's not in …
"I mean, stuff happens. It's a business. It's not in …
"I mean, stuff happens. It's a business. It's not in …
"I mean, stuff happens. It's a business. It's not in …
"Jakucionis, he's family. He's an incredible player," …
"Jakucionis, he's family. He's an incredible player," …
Maliek Collins agrees to terms on contract extension
Maliek Collins to remain in Cleveland for two additional years
Investment driving growth at NWS Crane
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Former Coach Urges Vikings to Blow Up Kyler Murray Experiment; Trade for… Kirk Cousins?
Jon Gruden has an insane trade idea for the 5-0 Minnesota Vikings and involves a quarterback change that nobody would see coming...
Explore Health, Oregon’s new health insurance marketplace, is ready for business
This fall, Oregonians who buy health insurance directly instead of getting it through their employer will need to use a new website, the Explore Health marketplace.
Explore Health, Oregon’s new health insurance marketplace, is ready for business
This fall, Oregonians who buy health insurance directly instead of getting it through their employer will need to use a new website, the Explore Health marketplace.
Denzel Ward to take part in pregame warmups
Denzel Ward's status for Week 7 remains in question
Science Snapshots: October 25, 2026
Three key science updates in one minute: Starry Night’s dawn matched to Jul 22, 1889; cold boosts lifespan via BH2/BH4; cluster similar-buildings cools cities.
Clemson HC Dabo Swinney Waving White Flag on Season
Following a humbling loss to Virginia Tech, Dabo Swinney is recalibrating expectations as the Tigers abandon playoff dreams and fight to salvage a disappointing, sub-par season.
Health board still paying for research despite criticism over patient benefit
Betsi Cadwaladr health board was due to pay Bangor University £110,686 for two researchers.
Argument over purchase turns physical; suspect pulls gun at South Side business
KABB Fox News 29 San Antonio provides local news, weather forecasts, traffic updates, investigations, notices of events and items of interest in the community, sports and entertainment programming for San Antonio and nearby towns and communities in South Central Texas, including Bandera, Boerne, Carrizo Springs, Castroville, Cibolo, Converse, Crystal City, Cuero, Del Rio, Devine, Eagle Pass, Floresville, Fredericksburg, Goliad, Helotes, Hondo, Kerrville, Live Oak, New Braunfels, Pearsall, Pleasanton, Poteet, Poth, Sabinal, San Marcos, Seguin, Schertz, Somerset, Universal City, Uvalde, Windcrest.
Argument over purchase turns physical; suspect pulls gun at South Side business
WOAI NBC News Channel 4 San Antonio provides local news, weather forecasts, traffic updates, investigations, and items of interest in the community, sports and entertainment programming for San Antonio and nearby towns and communities in South Central Texas, including Windcrest, Uvalde, Universal City, Somerset, Seguin, Schertz, San Marcos, Sabinal, Poth, Poteet, Pleasanton, Pearsall, New Braunfels, Live Oak, Kerrville, Hondo, Helotes, Goliad, Fredericksburg, Floresville, Eagle Pass, Devine, Del Rio, Cuero, Crystal City, Converse, Cibolo, Castroville, Carrizo Springs, Boerne, Bandera.
r/opensource just banned AI, non-English speakers and more
The opensource subreddit’s new rules against AI have sparked a revolt.
Appleton-area high school sports results for Saturday, Oct. 24
High school tennis, volleyball, soccer and cross-country teams were in action.
Adam Schiff responds to DOJ’s Alaska threat: ‘it’s Alaska’s business’ to run elections
In an exclusive interview with Meet the Press, Sen. Adam Schiff (D-Calif.) says “it's not the federal government's business to run Alaskan elections,” after the Justice Department sued to block certification of Alaska’s election results if Sen. Dan Sullivan loses, due to another candidate with the same name appearing on the ballot.
Business co-owner kills man ‘acting irrationally’ outside Zumba class, NC police say
The business co-owner was carrying a firearm, Spindale police say.
Colts vs. Vikings
Here is how the ColtsRoundtable staff sees the Week 7 matchup between the Indianapolis Colts and Minnesota Vikings unfolding.
Full injury report for Sunday's Clippers vs. Thunder matchup
Full injury report for Sunday's LA Clippers vs. Oklahoma City Thunder matchup.
Iowa Football Was Never Truly A CFP-Caliber Team. The Loss To Minnesota Proved It
The Hawkeyes had plenty of momentum after the Washington game, but there's just too much inconsistency right now. Everything fell apart against Minnesota.
One Underrated Timberwolves Wing Gets High Praise From Chris Finch
Terrence Shannon Jr. is shaping up to be one of the Timberwolves' sneakiest threats.
Arkansas basketball displays true toughness against Gonzaga
The big story of the win over Gonzaga: These Hogs play defense
Guardians Middle Infielder is a Prime Trade Candidate
The Cleveland Guardians, fresh off an ALCS appearance, will be facing several tough decisions next season regarding their lineup. The 85-win team won their division and looks poised to repeat next year, but they face an enviable dilemma. What do they do with their influx of top, young talent, and how do they find them …
How LaLiga Turned a Global Soccer Brand Into an $87 Million U.S. Business
LaLiga’s successful expansion into North America shows how to turn a global sports brand into a sustainable business.
Pat Surtain II unlikely to play
Pat Surtain has good chance to suit up in Week 8 due to ankle injury
Local breakfast chain plans Derby expansion
The Easy Egg, a Wichita-based breakfast and lunch restaurant, recently announced plans to expand into Derby. Reports indicate the local chain will take over the space at 317 N. Rock
She voted for Trump every time. Then came cancer and the bills
Cindy Banda faces mounting medical bills after battling breast cancer. Despite the single mother's positive outlook, the financial strain combined with the high cost of living is overwhelming. And it's
Tune In: Orlando Pride vs Gotham FC on CBS Sports Network
The Pride host Gotham for the final home game of 2026
Can GE Vernova's Gas Turbines Make Up for a Collapsing Wind Business?
It's a red flag investors would rather not see waving, but most of them may not have put this shift in its proper perspective.
🚨 Barça's squad to face Real Madrid
Barcelona have just announced Hansi Flick's squad for tonight's Clásico against Real Madrid at the Spotify Camp Nou. Midfielder Orian Goren is the standout inclusion in Flick's 23-man squad. Reserve-...
Week 7 inactives for Saints
New Orleans declares seven players inactive versus Pittsburgh
Bill Belichick speaks on loss to Syracuse
What Bill Belichick said after UNC football lost to Syracuse.
The top 25 classic golf courses in Canada, ranked
We rank the best courses built in Canada before 1960.
Cuts to rural healthcare become key issue for upstate votes in race for NY governor
The fight over a consolidation plan for a hospital in Hudson captures a trend throughout the state.
Seamus Power, Austin Smotherman Share Lead In Windy Bermuda Showdown
Seamus Power and Austin Smotherman share the Bermuda Championship lead at 16 under, with fierce winds and PGA Tour playing privileges adding drama to Sunday's finale.
Utah Jazz Must Let Darryn Peterson Feel the Pressure
Shielding Utah’s prized rookie from high-stakes moments only stunts his growth. To secure their future, the Jazz must force Darryn Peterson to embrace the game-deciding pressure now.
Texas A&M Defense Folds Again As Alabama Exposes Aggies In Late Collapse
Texas A&M's defense surrendered 311 passing yards and two fourth-quarter touchdowns in a 31-20 loss to Alabama, raising more questions about Mike Elko's Aggies.
A simple liquid can stop cavities without drilling, major study confirms
A simple liquid painted onto teeth in seconds can stop cavities without drilling, injections, or anesthesia, according to a major clinical trial involving young children. The inexpensive treatment could spare thousands of children painful dental procedures and surgery while paving the way for broader FDA-approved use.
Oracle Academy in Greece wins three Hellenic Responsible Business Awards
Oracle Academy in Greece wins three Hellenic Responsible Business Awards
U of M fellowship aims to boost rural obstetrics training and keep labor and delivery units open
The partnership is launching the new, one-year family medicine obstetrics fellowship next summer to prepare family medicine physicians to provide advanced prenatal, maternity and newborn care in rural communities. The only other fellowship of this kind in Minnesota is at Essentia Health in Duluth.
Five new businesses coming to Hunt Valley Exchange, including Dunkin’ and indoor golf simulator
Five businesses are coming to Hunt Valley Exchange in northern Baltimore County, including a Dunkin’, indoor golf simulator studio, Indian restaurant and wine and spirits store.
How whimsical Hands Gallery became a fixture in downtown SLO for 35 years
The popular shop offers a curated mix of local art, crafts, gifts and more on Higuera Street.
Explosion, fire blast through Iowa Quaker Oats plant
An apparent explosion at the Quaker Oats plant in Cedar Rapids sent thick black smoke over downtown Iowa as firefighters battled the massive blaze.
Svilar eyes return from injury vs Manchester United
Gian Piero Gasperini can hope for a return to goal for his regular starter before the new international break. According to Riccardo Trevisani on Radio Manà Manà Sport Roma, Mile Svilar could recove...
Knoebels’ Hallo-Fun brings Halloween rides, treats and entertainment
FOX56 WOLF TV carries news, sports, weather and coverage of local events in the Wilkes-Barre, Pennsylvania area, including Mountain Top, Plymouth, Nanticoke, Kingston, Back Mountain, Scranton, Moosic, Pittston, Avoca, Edwardsville, Hilldale, Wyoming, Laflin, Yatesville, Pittston, Dupont, Sugar Notch, Korn Krest, Warrior Run and Larksville.
South Texas Health System (@stxhealthsystem)
2 likes, 1 comments - stxhealthsystem on October 25, 2026: "One Last Chance to Think Pink: Breast cancer remains the most common cancer among women after skin cancer, making routine screenings and early detection more important than ever. Mammograms can help identify breast cancer before symptoms appear, when treatment options may be most effective. Last week, South Texas Health System McAllen celebrated breast health and preventive care with a special Mammo Monday event featuring the vibrant sounds of mariachi music at the hospital’s main entrance. The celebration reflected STHS' ongoing commitment to encouraging women to prioritize their health through regular screenings. Now, there’s one final Mammo Monday remaining! Join us at STHS ER Mission on October 26 from 8 a.m. to 5 p.m. for the last breast cancer event of 2026. During the event, attendees can: 🎀 Learn about breast cancer screening options 🎀 Schedule a mammogram appointment 🎀 Receive a complimentary goodie bag while supplies last To help make preventive care more accessible, South Texas Health System is also offering reduced self-pay rates* throughout October: • 2D Mammogram: $100 • 3D Mammogram: $155 • Bone Density Screening: $160 A screening today could make all the difference tomorrow. Make your health a priority and encourage the women you love to do the same. For breast health resources and information on the Think Pink campaign, visit the link in our bio. *If not already a covered benefit of your insurance.".
Women's FA Cup clash against Rotherham United postponed
Following a pitch inspection at the BD Community Stadium, this afternoon's First Round Women's FA Cup clash between Leeds United Women and Rotherham United Women has been postponed.An update on the re...
NFL Week 7 expert picks, predictions: Moneyline, against the spread
A look at our expert picks for Week 7 of the 2026 NFL season.
2 reasons Colts can upset Vikings in Week 7 matchup
Former NFL coach Jon Gruden predicts the Colts will upset the undefeated Vikings, with ESPN analyst Seth Walder also backing Indianapolis.
College football scores yesterday: Results of top 25, notable games
More ranked teams lost to unranked foes in Week 8. Here are the scores from top 25, other notable matchups that took place in Week 8.
The top 25 modern golf courses in Canada, ranked
Our ranking of top modern Canadian courses returns, with Nos. 1 and 2 sitting side by side.
NFL.com Experts Rolling With Broncos In Week 7
Fresh off a gritty win, Denver faces an injury-riddled Arizona squad as analysts eye a potential breakout performance for Bo Nix against the struggling Cardi...
New York Giants' Never-Ending Nightmare Might Get Even Worse
Things just keep getting worse for the New York Giants.
Marcos Leonardo Opens Up On A Difficult Start At Ajax
Following Ajax's win against Atalanta, Marcos Leonardo spoke about a difficult start at Ajax.
Paris Pressure: Saints Must Block Out the Chaos and Finish Their Business Against the Steelers
‘Healthy’ daughter, 26, dies suddenly—now family think they know why
Her grieving sister told Newsweek she had no idea her sibling's unusual flexibility was a sign of a "deadly condition."
Review: 'Whalefall' a big fish tale thriller within a fraught father/son relationship
Movie reviewer Joshua Hill says 'Whalefall' combines a fraught father/son relationship with a suspenseful narrative featuring excellent sound design and imagery.
Powers Health Community Hospital Achieves Statewide Milestone in Treating Heart Valve Conditions
Powers Health Community Hospital has successfully performed Indiana’s first procedure using the SAPIEN M3™ transcatheter mitral valve replacement (TMVR) system, a minimally invasive treatment for …