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Madison Square Garden Entertainment Corp. (MSGE) To Remain Fully Operational Amid New York Penn Station Redevelopment
Madison Square Garden Entertainment Corp. (NYSE:MSGE) is one of the top stocks to buy according to Ariel Investments. On June 9, Madison Square Garden Entertainment Corp. (NYSE:MSGE) entered into a non-binding agreement with Penn Transformation Partners for the development of the New York Penn Station. Under the terms of the agreement, Madison Square Garden will […]
NASA's Hubble spots a stellar sparkler for the Fourth of July
NASA's Hubble Space Telescope has captured a spectacular red, white, and blue view of one of the Milky Way's oldest star clusters to celebrate the nation's 250th anniversary. Hidden within the ancient cluster are clues to how exploding stars helped transform the young universe into one capable of forming planets and, eventually, life.
AI is already reshaping US politics at every level
Artificial intelligence is barging into the workplace and transforming the battlefield. Now, it’s coming to the ballot box, promising to rewrite the DNA of politics. Driven by a flood of
Zak Brown explains how McLaren ended toxic blame culture
Zak Brown says McLaren’s transformation into a championship-winning team was driven by a no-blame culture and a major leadership reset
This satellite constellation transformed earth science by creatively tuning in to GPS signals
When NASA's Cyclone Global Navigation Satellite System, or CYGNSS, launched into orbit in 2016, none of the University of Michigan Engineering researchers who developed the system expected it to transform ...
13 IKEA Finds That Will Upgrade Your Home Office
These popular standing desks, monitor stands, and more will transform your home office into a sleek, organized space with ergonomic design.
Folder with Taylor Swift and Travis Kelce’s alleged wedding plans spotted at MSG amid reports they’ve ‘transformed’ the venue
A folder seemingly dedicated to Taylor Swift and Travis Kelce's wedding has been spotted at Madison Square Garden amid reports that the couple 'transformed' the midtown Manhattan venue.
Ford reports Q2 sales down 10% as it transforms the business
Ford reported a decline in Q2 U.S. sales as commercial fleet sales pulled back and pickup production struggled to catch up after a fire at a supplier.
One Nation, Under Construction
To celebrate America’s 250th birthday, President Trump transformed Washington into a mess.
How PepsiCo is shaking up business as usual
By committing to AI and embracing digital transformation, the food and beverage giant is driving growth in innovative ways
Microsoft Frontier Company: AI engineering that amplifies and protects your intelligence
The pace of AI adoption is moving incredibly fast. Customers have moved well beyond experimentation and understand the importance of adopting AI to transform their business. They are now concentrating on delivering measurable business outcomes and demonstrating a return on their AI investments, while ensuring their intelligence is amplified and their IP is protected. Today...
'The old politics are gone': Steve Bannon on the democratic socialist wave
Trump's former White House chief strategist argues the U.S. is in a transformational political moment — and leadership in both parties are way behind.
Applications Opened July 1 for Wyoming's Rural Health Transformation Funding
CHEYENNE, WY – Today, the Wyoming Department of Health (WDH) announced the opening of Requests for Applications (RFAs) for Wyoming’s Rural Health Transformation Program, a major initiative designed to strengthen healthcare access, improve health outcomes, and support innovative solutions for rural communities across the state. The funding opportunity represents an important step in implementing […]
Discover the Entertainment at Le Mans Classic Legend 2026
Le Mans Classic Legend (2–5 July 2026) transforms the 24 Hours of Le Mans circuit into a world where heritage, music, cinema, the French art of living and the a
This satellite constellation transformed earth science by creatively tuning in to GPS signals
Governments and companies have launched similar constellations to use the method, called GNSS-R, to monitor and forecast wildfires, flooding and more.
Business Income Has Moved Beyond Corporations, and Tax Policy Must Follow
Since the 1980s, partnerships have displaced traditional C corporations as the largest source of business income, transforming business taxation and contributing to rising economic inequality.
How cognitive automation can transform your business
Zapier reports that cognitive automation enhances business efficiency by enabling machines to interpret information and make decisions, unlike traditional automation.
This satellite constellation transformed earth science by creatively tuning in to GPS signals
Key takeaways —The first constellation to produce high-quality data by picking up GPS microwaves reflecting off Earth, called CYGNSS, is featured in the Smithsonian National Air and Space Museum's Living in the Space Age exhibit. —Distortions in the reflected signals can reveal information about Earth, including hurricane wind speed and the distribution of moisture in soil, and the constellation provided unprecedented coverage in both time and space. —GNSS-R data is useful for mon
Newsom Vowed To Transform Kids’ Mental Health. Many California Schools Are Still Waiting.
Gov. Gavin Newsom launched an ambitious initiative to make public schools the epicenter of mental health services for young people. Five years after he promised transformation, many schools have struggled to get the program up and running, and hundreds more have yet to try.
NC’s first full budget since 2023 reflects transformed health policy landscape
North Carolina's first full budget since 2023 reflects Medicaid expansion, Healthy Opportunities Pilot funding, SNAP changes and new federal health policies.
How Wisconsin Used Foxes And Deer To Revamp Science Education
Public input identifying over 100 million trail cameras photos of Wisconsin’s animals has transformed science education and state wildlife management.
North Dakota opens wellness equipment funding opportunity for rural hospitals | Health and Human Services North Dakota
From fitness and recovery equipment to mindfulness tools and wellness spaces that help reduce burnout, North Dakota Health and Human Services (HHS) is investing in the health and well-being of rural healthcare workers through a new funding opportunity for rural hospitals.Applications are now open for the Hospital Wellness Equipment funding opportunity through the North Dakota Rural Health Transformation Program (RHTP), providing resources to help rural North Dakota hospitals create healthier workplaces and support the physical, mental and emotional well-being of their workforce.
What 124 Future Business Leaders Really Think About AI and Work
Insights from 124 career assessments written by UMD-Smith graduate students show 98% expect artificial intelligence to transform, not eliminate, their careers. The analysis also found AI raises performance expectations while increasing demand for strategic thinking, AI literacy, ethical judgment and critical evaluation of AI-generated work.
Match for the Marsh with Barton Health
We’re back with another awesome opportunity to transform the south end of the Upper Truckee Marsh, this time with help from our friends at Barton Health! Now that the California Tahoe Conservancy has demolished the former Motel 6 building, restaurant, and parking lot from the Upper Truckee Marsh in South Lake Tahoe, planning is underway […]
'American Horror Story' reveals 'Love Story' heartthrob's blond transformation
'American Horror Story' reveals 'Love Story' heartthrob Paul Anthony Kelly's blond transformation for season 13.
America at 250: Innovations That Transformed Business
Wharton faculty explore the American business innovations that transformed industries, reshaped markets, and changed the way the world works.
'Shrek 5' trailer sparks backlash over Fiona's 'problematic' transformation
Fans aren't happy about Fiona's "problematic" transformation in the latest "Shrek 5" trailer. Here's what experts say about the observations.
FMOL Health pegs Cancer Institute investment at $70M, shares timeline
FMOL Health expects to invest roughly $70 million to transform the former Bone & Joint Clinic of Baton Rouge building into a new home for the Our Lady of the Lake Cancer Institute, according to E.… Already an INSIDER? Sign in. Already an INSIDER? Sign in
Drake University’s Zimpleman College of Business Earns High Rating for Societal Impact
Drake Achieves Level 4 ‘Transforming School’ Designation in the 2026 Positive Impact Rating Drake University and the Zimpleman College of Business have once again secured their position as a global leader in responsible education, earning the prestigious Level 4 “Transforming School” designation in the 2026 Positive Impact Rating (PIR) for business schools. The Positive Impact...
Computer scientists develop a new AI tool that rivals AlphaFold 3 in mapping RNA
The method, called RNAbpFlow, was described in a study published on June 30 in Nature Methods, among the most selective journals in computational life sciences.
Nokia, SAP and Microsoft Enter Strategic Multi-Year Agreement to Advance Cloud- and AI-Driven Business Transformation
Nokia will accelerate its enterprise transformation using RISE with SAP Methodology, with SAP S/4HANA hosted on Microsoft Azure.
Meet a PhD student selected for a national Science, Mathematics, and Research for Transformation Scholarship | CWRU Newsroom
Jenna Jaklich is nearly three years away from completing her PhD program in materials science and engineering at Case Western Reserve University, but...
Action! NSF–DOE Vera C. Rubin Observatory Begins Capturing the Greatest Cosmic Movie Ever Made
The wait is over: NSF–DOE Rubin Observatory, funded by the U.S. National Science Foundation and the U.S. Department of Energy’s Office of Science, is now capturing the cosmos in unprecedented detail, transforming the way we study the dynamic Universe.
Developer addresses community concerns around Franklin youth sports complex project
The project, proposed by developer BLVD Capital, would transform Brownland Farm, a 233-acre property on Hillsboro Road just outside downtown Franklin, into “The Banks at Brownland.”
Scientists Found Ancient Human DNA on Cave Walls for the First Time and It Could Rewrite the Story of Prehistoric Art
The find could transform how researchers study prehistoric cave art.
This Compact, Emission-Free Gas Turbine Is Rocket Science
This week’s Current Climate newsletter also looks at America lagging in EVs and charging infrastructure, and Sunrun’s transformation into a company
Cleveland Clinic Tackles Hunger, Housing and Maternal Health
In 2025, our teams continued to address critical social drivers of health, expand access to care and resources, and build stronger, healthier communities.
Millions of exploding stars could soon reveal dark energy's secrets
A new AI-powered framework could transform how astronomers measure the expansion of the Universe. By analyzing images of Type Ia supernovae and modeling their environments in unprecedented detail, researchers can estimate cosmic distances with near-spectroscopic accuracy. The technique is designed for the flood of data expected from the upcoming Vera C. Rubin Observatory and may greatly improve our understanding of dark energy.
Building Business: New hotel taking shape on Portland's Monument Square
Zachau Construction is transforming the former Fidelity Trust building into a 101-room luxury hotel, for Jim Brady’s Fathom Cos.
Now your pet can get world-class healthcare. Here’s how.
Doubtless CEO Dirk Beeckman reveals how modern products and services are transforming the pet-parent experience
Orlando Magic Have Something to Prove After Latest Power Rankings
New head coach Sean Sweeney faces immense pressure to transform Orlando's talented core into postseason contenders and silence doubters following a mediocre mid-pack ranking and trade rumors.
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
3 Traps Health Systems Fall Into When Trying to Improve Their Culture
Cultivating a positive culture is a priority for hospital leaders, but many are making avoidable mistakes. Myra Gregorian, Seattle Children's chief people and transformation officer, outlined some of these common blunders — such as not involving frontline staff in decision making and assuming that simple communication methods are sufficient.
Important Penn State prospect makes notable physical transformation
Penn State star Max Granville’s career has been stunted by injuries so far, but his body transformation is sure to excite fans.
Maine targets three initiatives for initial use of federal rural health funds
The Mills administration says it's decided how it will spend nearly half of the $190 million it's received this year through the federal Rural Health Transformation Fund.
Here are June business openings, closings and what's coming to Abilene
Abilene saw business changes in June. See the month's new openings, re-openings, and grand restaurant transformations.
Vancouver turns its Science World museum into a giant 17-story soccer ball for the World Cup
It started with a whimsical idea. Why not transform the landmark Science World museum in downtown Vancouver, the geodesic dome-topped building not far from BC Place stadium, into a gigantic 17-story soccer ball for the World Cup?
Vancouver turns its Science World museum into a giant 17-story soccer ball for the World Cup
It started with a whimsical idea. Why not transform the landmark Science World museum in downtown Vancouver, the geodesic dome-topped building not far from BC Place stadium, into a gigantic
What scientists discovered about coffee grounds will transform construction industry - Futura-Sciences
At the start of 2024, a study published several months ago is once again drawing attention. Scientists at RMIT University in Australia have identified an unexpected use for spent coffee grounds, opening the door to a promising solution for both the construction sector and organic waste management. From coffee waste...
Old Lord and Taylor building transforms into food and entertainment destination in Midtown
The former Lord and Taylor building has reopened and now offers restaurants, bars and curated eateries.
From Linchpin to Lever — Part 1: Measuring Trust in Public Health
Learn how local health departments can measure public trust using existing public health tools to strengthen relationships and improve community health outcomes.
Chairman Guthrie, Health Vice Chair Harshbarger, Congresswoman Miller-Meeks Lead Site Visit to Iowa Hospitals to Highlight Benefits of the Rural Health Transformation Program
The Committee on Energy and Commerce is the oldest standing legislative committee in the U.S. House of Representatives and is vested with the broadest jurisdiction of any congressional authorizing committee.
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
Nevada takes step toward becoming corporate litigation hub with business court pilot program
The Clark County District Court this week announced it has restructured its departments to include a dedicated business court. The restructuring is expected to bring down case adjudication times, and it could help an ongoing effort to transform Nevada into a premier destination for corporate litigation. Judges Maria Gall and Joe Hardy–Departments 9 and 15, […]
NTT DATA | Transforming Data Into Exceptional Fan Experience
We worked with Penske Automotive Group to create a mobile application to amplify the fan experience and make the iconic Indianapolis Motor Speedway a smart venue through NTT Smart Solutions.
Gay Street businesses cope with Capital Line construction
The Capital Line is meant to be transformative for Downtown. But right now it's presenting challenges for businesses.
233-acre Franklin farm could become major youth sports complex
A Nashville Predators-operated ice rink and athletic facility could transform historic Franklin property.
Lucky the Bull Gets a Transformation
A local artist has been working for weeks on restoring a historic landmark that will soon be making a public appearance.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Game On Retro owner plans entertainment empire expansion, Coram movie theater transformation
Plans include opening a new arcade, store and transforming a shuttered movie theater in Coram.
How 12 ventures will improve health and food systems in Boston
Yes/Boston has announced its 12-member cohort through the UpLink Innovation Challenge to drive local innovation and transform food and health in Boston.
Health systems must shift AI use from automation to transformation
While healthcare investments in AI are two to three times that of other industries, most providers focus AI's power on tackling administrative tasks. But AI's true value is in transforming care, explain experts at the HIMSS AI in Healthcare Forum.
CEOs and CIOs Differ Sharply on AI Business Impact and Transformation Success, Protiviti Survey Finds
/PRNewswire/ -- A new Protiviti Global Transformation Survey, The Alignment Advantage in Transformation, finds a significant gap between CEOs and technology...
The Business of Beauty Global Forum: Our Place in Culture
Paloma Elsesser, Byunghoon Kim and Emma Dabiri discussed the global cultural shifts transforming today’s beauty standards on the first day of The Business of Beauty Global Forum 2026.
CHI Health debuts new orthopedic center in west Omaha
CHI Health is transforming its orthopedic care. On Wednesday, the organization broke ground on their new Lakeside Hills center. This will support patients from their initial diagnosis to recovery.
Online violence against women in politics: what shapes political party responses to technology-facilitated gender-based violence?
Political parties have a primary role to play in tackling online violence against women and gender diverse politicians. While the prevalence and impact of TFGBV, such as coordinated disinformation campaigns, deepfake image-based sexual abuse or trolling are well documented, many parties are still building their knowledge on how to respond effectively and have not put in place internal practices and policies that respond to the rapidly evolving, poorly regulated digital ecosystem. About the ReportIn order to promote and protect fair and democratic participation in politics, this ALIGN Report explores what political parties are doing in response to TFGBV and what factors shape their action. The findings, based on existing literature and interviews with gender and politics professionals, indicate there are three sets of factors which donors, civil society and practitioners should consider when designing action to support political parties to respond to TFGBV internally. These are: (1) gender norms; (2) socio-political environment; and (3) internal party factors.Key messagesUnequal gender norms are ubiquitous across politics, shaping expectations of leaders to be strong and assertive, and practices of political parties to uphold masculinist values and sustain cultures of silence. These often lead to weak response to TFGBV against women politicians.The socio-political context can incentivise or disincentivise action, depending on the salience of gender issues, which are increasingly weaponised. Electoral competitiveness, domestic laws (i.e. quota requirements), and even the political system or global normative frameworks influence political will to act.Internal party factors that shape responses will vary across countries and contexts, but include: structures to enforce codes of conduct, policies and reporting mechanisms on (TF)GBV, political ideology, extent of centralisation of leadership, and crucially the meaningful participation of women in decision-making positions, not least through internal women’s wings.Party responses can be seen as a spectrum, with actions falling between active discouragement to address TFGBV to commitment to transform unequal norms and practices within the party.About the ToolkitTogether with the report, this ALIGN toolkit offers gender professionals and others working on democratic strengthening a set of guiding questions and reflection prompts to identify which responses could be most effective and suitable in different contexts. These actions can complement other solutions to TFGBV, such as regulations promoting safety by design. The assessment spans a broad range of factors including: (1) different manifestations of gender norms, (2) the socio-political environment and (3) internal party structures.Key messagesPolitical parties are duty-bound to take action internally to respond to the significant threats posed to women members and candidates, including from their own party colleagues, affiliates and political peers.Existing party approaches to TFGBV can be assessed along a spectrum which ranges from active discouragement and passive acceptance to minimal response and transformative change.To generate effective and context-appropriate solutions to TFGBV, it is important to consider how gender norms shape leadership expectations and internal party practices, while also analysing the impact of the socio-political environment. While actions to support women to stay safe online are very common, codes of conduct and measures to strengthen women’s voice and power in the parties are proposed as most transformative solutions.
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