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Siemens Healthineers receives up to $31M to develop autonomous robot for remote stroke treatments

The funding, provided over five years, will go toward developing a robot capable of performing advanced endovascular procedures without direct human input.

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Aug 21 • 10:18 AM EDT • Business • cardiovascularbusiness.com
A Mother’s Age Can Affect Her Offspring in Ways Scientists Are Only Starting to Understand

The effects of maternal age may travel through generations without being written into DNA.

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Aug 21 • 10:15 AM EDT • Science • zmescience.com
Westcott businesses left without air conditioning after thieves wreck rooftop units

The owner of the building said it'll cost at least $55,000 to replace the units

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Aug 21 • 7:00 AM EDT • Business • syracuse.com
Opinion | Walz said ‘follow the science.’ His mining order does the opposite.

"The governor’s executive order throws six years of progress into question without new science, new legislation or the opportunity for a vote by our elected representatives," Dave Lislegard writes.

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Aug 21 • 5:59 AM EDT • Science • startribune.com
Penguins Trade Proposal Sends Sidney Crosby To Eastern Rival

It goes without saying that Pittsburgh Penguins icon Sidney Crosby will forever be a sports legend in the Steel City.Since being selected first overall in the 2005 NHL Draft, which was famously dubbed the “Crosby sweepstakes”, Crosby has helped lead the Penguins to three Stanley Cup championships while establishing himself as one of the greatest […] The post Penguins Trade Proposal Sends Sidney Crosby To Eastern Rival appeared first on HEAVY.

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Aug 20 • 8:45 PM EDT • Sports • sports.yahoo.com
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Yankees’ Aaron Boone Reveals Important Injury Update on Aaron Judge

The New York Yankees have been without superstar Aaron Judge for over two months due to a rib injury, and whether or not he’ll return this season remains a major question.New York has made it known that the plan is for him to return this season, and on Thursday, before the team’s series finale against […] The post Yankees’ Aaron Boone Reveals Important Injury Update on Aaron Judge appeared first on HEAVY.

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Aug 20 • 8:25 PM EDT • Sports • sports.yahoo.com
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This weight-loss hormone may protect the liver even without weight loss

A hormone already known for curbing appetite and supporting weight loss may have a surprising second job: protecting the liver from inflammation and scarring. Researchers at McMaster University found that GDF15 activates a previously unknown brain-to-liver pathway that triggers the release of glucocorticoids, helping calm immune activity in the liver.

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Aug 20 • 8:00 PM EDT • Science • sciencedaily.com
Targeted Care connects patients to right mental health support at right time

FORT Polk, La. - Walking into a mental health clinic and asking for help can be difficult. Walking out without the specialty mental health appointment y...

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Aug 20 • 5:38 PM EDT • Health • army.mil
Deadlock on steep health insurance cost increases for school staffsNJ Spotlight News

Without a decision on 34% higher rates, a New Jersey commission pushes a vote to next month, while open enrollment nears

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Aug 20 • 11:44 AM EDT • Health • njspotlightnews.org
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The Science And Lingering Human Toll Of A Recent Midwest Derecho

Two weeks later, many communities in the Midwest are without power. An expert explains the science and human toll of a late-summer derecho.

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Aug 20 • 8:10 AM EDT • Science • forbes.com
Barcelona face striker dilemma - could they cope without one?

Barcelona are heading into the new La Liga season without an established striker, with Hansi Flick yet to replace Robert Lewandowski and Ferran Torres.

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Aug 20 • 4:45 AM EDT • Sports • sports.yahoo.com
The “Asian water tower” is losing 24 billion tonnes of groundwater every year

The “Asian Water Tower” is losing roughly 24.2 billion tonnes of groundwater every year, with some of the worst declines hitting densely populated farming regions. Glacier melt may temporarily soften the crisis around the 2060s, but without changes in water use, researchers expect depletion to accelerate afterward.

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Aug 19 • 8:00 PM EDT • Science • sciencedaily.com
Beware the Business Owner Without Battle Scars. Here's What Their Perfect Story Is Really Hiding.

The entrepreneur with no scars worries me far more than the entrepreneur who can point to several. At least the second person has been in the arena.

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Aug 19 • 2:00 PM EDT • Business • entrepreneur.com
‘Most Valuable Athlete on Earth’ — Sports World Split Over Whether WNBA Would ‘Drop Off a Cliff’ Without Caitlin Clark

Caitlin Clark is currently averaging 22. 1 points, 8.

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Aug 19 • 12:41 PM EDT • Sports • sports.yahoo.com
Salma Hayek Pinault stars in fiery trailer for Angelina Jolie’s ‘Without Blood’: ‘How can God forgive you?’

Oscar-nominated actors Salma Hayek Pinault and Demián Bichir crackle opposite each other in the new look at the war drama ‘Without Blood’ from writer-director Angelina Jolie.

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Aug 19 • 12:07 PM EDT • Entertainment • ew.com
COOL vs growing the business

Contrasting emails highlight the ongoing COOL controversy while beef industry experiences record demand and producer prosperity without mandates.

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Aug 19 • 9:46 AM EDT • Business • beefmagazine.com
Paleontologists stunned by 2024’s most jaw-dropping fossil discoveries - Futura-Sciences

France’s Show-Stopping Fossil Finds How could we kick off this year in paleontology without highlighting the three blockbuster discoveries on French soil? While France is already renowned for its fossil-rich lands, it was the finds in Hérault’s Cabrières site in the Montagne Noire range that truly wowed the scientific community...

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Aug 19 • 9:00 AM EDT • Science • futura-sciences.com
A broken mental health system has kept a Long Beach father locked up without a trial, his family says

Kaizann Guerrero's mother says he was doing well, with his schizophrenia under control, until he was sent to a state mental hospital following his arrest.

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Aug 19 • 8:00 AM EDT • Health • lbpost.com
How the Wisconsin governor’s race became a data center hate-off

Both candidates are trying to surf the anti-tech wave — without fully betraying the AI boom’s beneficiaries.

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Aug 19 • 6:00 AM EDT • Politics • vox.com
As Seas Rise, Scientists Race to Save Coastal Marshes From Drowning

A majority of coastal wetlands are on track to shift inland or disappear in the coming decades without intervention. That will have major consequences.

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Aug 19 • 4:55 AM EDT • Science • insideclimatenews.org
Arman Tsarukyan says controversy is ‘important’ for ‘boring’ fighters

Arman Tsarukyan believes fighters without exciting fighting styles need to somehow find a way to draw attention.

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Aug 19 • 2:34 AM EDT • Sports • sports.yahoo.com
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Claude can now send emails in Gmail, even without your approval

Anthropic’s Claude AI can now take a huge step in your email inbox, with the ability to not only interact...

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Aug 18 • 5:20 PM EDT • Technology • 9to5google.com
Trump halts talks with Iran, signaling a new approach in the nearly 6-month war

For weeks, President Donald Trump has tried willing positive developments with Iran into existence, without much success.

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Aug 18 • 4:39 PM EDT • Politics • cnn.com
Science Night Live returning to Orlando Science Center

Science Night Live offers adults the chance to let their curiosity shine at the Science Center, without the kids. (COURTESY OF THE ORLANDO SCIENCE CENTER) They say you never stop learning no matter how old you get. Well get ready to take that endless curiosity to the Orlando Science Center this Saturday, August 22, for

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Aug 18 • 4:34 PM EDT • Science • yourcommunitypaper.com
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Collin County residents without health insurance have few places to turn

Collin County has few options for people without medical insurance who need health care.

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Aug 18 • 5:57 AM EDT • Health • keranews.org
UToledo Health Performs Northwest Ohio’s First Histotripsy Procedures

Histotripsy uses focused sound waves to break down tumors without incisions, heat or radiation.

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Aug 18 • 4:00 AM EDT • Health • news.utoledo.edu
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As injury woes resurface, what comes next for Cubs?

The Cubs will be without a couple of key players and have to figure out backup plans as injury woes resurface on the North Side of Chicago.

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Aug 17 • 9:17 PM EDT • Sports • sports.yahoo.com
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Stein vetoes pair of bills making election, judicial changes

House Bill 958 would shorten early voting windows, and House Bill 377 would allow the state's chief justice to suspend trial court judges without pay.

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Aug 17 • 4:59 PM EDT • Politics • spectrumlocalnews.com
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Miami landlord disputes knowledge of Pace Corners business license issue

A Miami landlord says he was not aware his Augusta apartment complex was operating without a business license, but an open records request obtained by News 12 shows otherwise.

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Aug 17 • 4:39 PM EDT • Business • wrdw.com
Trump blames vandals for damaged grass in the spot where he held his July 4 celebration

Trump has repeatedly blamed vandals for damage to his renovation projects in the nation's capital, often without evidence and sometimes despite opposing accounts from his officials.

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Aug 17 • 3:47 PM EDT • Politics • pbs.org
Sony Ends Stonks-9800 Dev's Publisher Agreement Without Warning

'PlayStation Support refuses to listen to my arguments or even respond to my emails in any way,' stated Ternox Games

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Aug 17 • 9:46 AM EDT • Technology • kotaku.com
Low-fat vegan diet helps people lose weight without eating less

A low-fat vegan diet may help people lose weight without counting calories, shrinking portions, or feeling constantly hungry. In a 16-week clinical trial, people eating mostly fruits, vegetables, grains, and legumes consumed about 357 fewer calories per day even though the total amount of food they ate barely changed.

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Aug 17 • 8:00 AM EDT • Science • sciencedaily.com
Everyday Injustice Podcast Episode 337: Marc Bookman Examines the Death Penalty’s Politics, Failures and Enduring Appeal

Marc Bookman, legal director of the Atlantic Center for Capital Representation, recently discussed capital punishment on Episode 337 of 'Everyday Injustice.' Bookman challenged the perception of a national death penalty resurgence, asserting its continued application is increasingly confined to a limited number of states. He also critiqued public opinion polling on capital punishment, specifically a Pew poll, for failing to present alternatives such as life without parole. Additionally, Bookman previewed his forthcoming novel, 'Albert's Time,' which explores the ethical dimensions of capital punishment by confronting the execution of an undeniably guilty individual.

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Aug 17 • 7:10 AM EDT • Politics • davisvanguard.org
Former Oilers Coach Reveals True Feelings Of Connor McDavid

It goes without saying that Edmonton Oilers captain Connor McDavid is regarded as the top player on the face of the Earth right now, and his Hall of Fame credentials are already set in stone despite his career being barely over a decade old.McDavid has also played under numerous head coaches since being selected first […] The post Former Oilers Coach Reveals True Feelings Of Connor McDavid appeared first on HEAVY.

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Aug 17 • 1:57 AM EDT • Sports • sports.yahoo.com
Arizona Cardinals RB Jeremiyah Love Facing Extended Absence

The Arizona Cardinals are now less than a week from entering the third game of the 2026 preseason slate.This one will seemingly be without April’s third overall pick in RB Jeremiyah Love, who is likely not playing this week – or the remainder of the preseason.ESPN insider Adam Schefter broke the news that Love is […] The post Arizona Cardinals RB Jeremiyah Love Facing Extended Absence appeared first on HEAVY.

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Aug 17 • 1:56 AM EDT • Sports • sports.yahoo.com
Over 10,500 Central Virginia homes, businesses without power amid severe thunderstorms

Over 10,500 Central Virginia homes and businesses are without power Sunday evening amid severe storms.

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Aug 16 • 11:18 PM EDT • Business • wric.com
The Scientists Who Want to Steer Hurricanes

Over the weekend, Hawaii was lashed by Hurricane Lala, which has washed away homes, left more than 125,000 people without power, shut down two of the state’s busiest airports, threatened dangerous flash flooding and, at time of writing, has killed one person. What if we could’ve steered the storm away from Hawaii, into the vast expanse of the empty Pacific Ocean that lies all around the islands—where no one could get hurt? This scenario might sound like the stuff of science fiction. But earlier this year, a peer-reviewed study published by the Public Library of Science found that it might be possible, and sooner than we think. The study was titled: “Weather Jiu-Jitsu: Prospects for atmospheric nudging to defuse the impact of catastrophic weather extremes.” According to the paper, the controversial practice of cloud seeding could enable human beings to make hurricanes change direction. The potential results could be astounding: The authors suggested that Hurricane Sandy, which in New York City alone killed 44 people and caused $19 billion of damage in 2012, could’ve been diverted by 200 miles, missing the metropolis entirely. Cloud seeding, which first succeeded in the U.S. in 1946, is a practice whereby small particles—for example, dry ice, silver iodide, or salt—are dropped into clouds, causing moisture to condense into precipitation. In the 1960s, the U.S. government launched Project Stormfury, an experiment that saw Navy pilots flying into the heart of a hurricane, dodging winds over a hundred miles per hour, to cloud-seed inside it, in the hope of reducing the storm’s power. “The seeding,” the theory went, “would stimulate the formation of a new eyewall that would surround the existing eyewall. The new eyewall would contract, strangling the old eyewall and reducing the intensity of the hurricane.”

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Aug 16 • 4:43 PM EDT • Science • thefp.com
CENTCOM commander touts USS Abraham Lincoln mental health record after more than 260 days without port call

CENTCOM Adm. Brad Cooper said the Lincoln's leadership has prioritized mental health as the carrier nears the end of its extended deployment.

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Aug 16 • 4:30 PM EDT • Health • foxnews.com
Analysis: City's post-Guardiola era starts with loss

Manchester City were playing their first competitive game without Pep Guardiola as their manager in over 10 years.

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Aug 16 • 2:37 PM EDT • Sports • sports.yahoo.com
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Saber Interactive finally adds an AI disclaimer to Rideshare Stimulator's Steam page

Saber Interactive has added an AI disclaimer to Rideshare Stimulator's Steam page, days after the game first went live without one.

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Aug 16 • 1:34 PM EDT • Technology • eurogamer.net
I Tried Large Format Photography on a 70-Year-Old Camera (Without Spending a Dime on Film)

After 20 years of avoiding intimidating 4-by-5 cameras and $11-a-shot film, I finally tackled my large format anxiety using an innovative digital attachment and my smartphone.

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Aug 16 • 12:00 PM EDT • Technology • pcmag.com
ChatGPT’s Computer History tracks your clicks and keystrokes

It’s like Windows Recall, but without all the creepy screenshots.

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Aug 16 • 10:56 AM EDT • Technology • theverge.com
Age slower without dieting: this cultural habit stuns scientists worldwide - Futura-Sciences

Savoring Culture: A Surprising Health Ally Picture this: according to a British study involving more than 3,500 adults, a weekly dose of culture—be it through visiting museums, browsing in a library, humming along in a choir, or wielding a paintbrush—was linked to knocking one year off participants’ biological age, and...

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Aug 16 • 10:30 AM EDT • Science • futura-sciences.com
Hebrew University scientists discover way to create real dairy proteins from plants

The discovery would thus help overcome a major hurdle in producing real dairy proteins without cows, paving the way for more sustainable dairy ingredients and less climate change.

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Aug 16 • 7:50 AM EDT • Science • jpost.com
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You Can Use Your Old Android Phone As A Universal Remote - Here's How

Looking for a way to control your devices without buying an expensive new remote control? You may be able to use an old Android phone instead.

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Aug 16 • 6:17 AM EDT • Technology • bgr.com
Can’t Live If Living Is Without You, Nilson!

Angulo’s physical presence may prove a useful attribute, if we draw some cloggers in the Europa League group stages.

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Aug 16 • 1:00 AM EDT • Sports • sports.yahoo.com
Castro-style capitalism: Havana promises economic changes without relinquishing political control

Economists and business leaders argue that Cuba cannot build a new economy without institutional reform, something the island’s government appears unwilling to negotiate

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Aug 16 • 12:00 AM EDT • Politics • english.elpais.com
I freed up 10GB of Gmail space in 5 minutes without deleting important emails

It's about time I audited my inbox

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Aug 15 • 1:00 PM EDT • Technology • androidpolice.com
Serie A livestream: How to watch Serie A for free

Live stream select Serie A fixtures without spending anything.

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Aug 15 • 5:00 AM EDT • Entertainment • mashable.com
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Chinese sensor feat may help smart watch detect submarine 500 metres deep

Compact chip containing Hall-effect sensor can pick up faint magnetic fields by generating a tiny voltage without increasing noise output.

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Aug 14 • 11:00 PM EDT • Science • scmp.com
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Morgan McGarvey calls for reversal of change to asylum process

McGarvey wants the Trump administration to reverse the change, which allows officers to refer certain asylum applications to a judge without first conducting an interview

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Aug 14 • 5:48 PM EDT • Politics • spectrumnews1.com
Patent before publication without limiting open science

Patent before publication when research has broader potential. See how technology transfer in academia can extend a discovery without limiting open science.

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Aug 14 • 4:00 PM EDT • Science • kevinmd.com
Vulnerability giving attackers full control of Macs is under active exploitation

Screen-sharing bug lets remote hackers log in without a password.

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Aug 14 • 2:32 PM EDT • Technology • arstechnica.com
Gunther Werks Built Its Fastest 911 Yet Without A Single Turbo

Only 15 buyers will get this analog Porsche, and each one comes with a matching carbon racing simulator

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Aug 14 • 12:30 PM EDT • Technology • carscoops.com
9 AI Tools Founders Say They Could Not Run A Business Without

Founders were asked to pick one AI tool each, and 3 names took most of the votes. Here are the 9 tools they say they could not run a business without today.

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Aug 14 • 8:00 AM EDT • Business • forbes.com
Epic launches new one-click feature allowing outside hospitals to share medical images without CDs

The Verona, Wisconsin-based vendor this month is rolling out its Care Everywhere Diagnostic Image Exchange across the Epic community.

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Aug 14 • 2:03 AM EDT • Business • radiologybusiness.com
Two Surprising Fruits That Boost Heart Health (Without Raising Blood Sugar)

Here's what researchers found when pairing avocado and mango

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Aug 13 • 6:05 PM EDT • Health • mindbodygreen.com
Small Tri-State businesses still impacted as over 30K people remain without power
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Aug 13 • 5:43 PM EDT • Business • local12.com
How to Support Your Partner Through a Health Crisis

A surprise diagnosis can change a relationship overnight. Here’s how to show up for your other half without losing sight of yourself.

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Aug 13 • 1:00 PM EDT • Health • gq.com
New AI technique helps robots complete tasks twice as fast by letting them 'think ahead'

A new AI system lets robots plan their next move while they're in motion — removing reaction delays and doubling task speeds without any extra computing overhead.

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Aug 13 • 12:57 PM EDT • Science • livescience.com
Can you live safely in Florida without AC? See health impacts

All 67 Florida counties are under a heat advisory. Here's why Floridians without air conditioning could see greater health impacts

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Aug 13 • 12:30 PM EDT • Health • naplesnews.com
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Trump admin marks 15 straight months with zero border releases as apprehensions plunge 94%

President Donald Trump's administration says it has gone 15 straight months without a single release at the border as apprehensions drop 94%.

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Aug 13 • 12:26 PM EDT • Politics • foxnews.com
A Bulldog in Business: How Moving into the Booth Opened Other Doors for Dodger Great Orel Hershiser

Orel Hershiser knows that he is a bona fide Los Angeles icon. But he has no illusions — he wouldn’t have the business opportunities he enjoys today without the platform provided by his broadcasting gig with the team. “You have a resume, but the resume slowly dies,” Hershiser says. “You have to be active. You …

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Aug 13 • 11:45 AM EDT • Business • sports.yahoo.com
AI needs science’s search history

“Actually, that’s where the gold is,” said Alasdair Russell, my graduate school friend who leads a pre-clinical genome editing group at Cambridge. He was talking about the winding road of science that is omitted from published papers. “When you’re discussing how to do the experiment, and why this way is better than another way, and what does the data really mean? I know what it shows, but what does it mean?” At RAAIS 2026, he described how his group has begun logging the twisting path of discovery as it happens, recording the verbal and written exchanges that normally disappear. Ideas become nodes in a living graph: they branch when a meeting produces two plausible experiments, merge when separate lines of evidence converge, and go dark when someone quietly stops pursuing them. In his implementation, one agent scores novelty, while another tries to learn “how scientists think and how they navigate through a complex world of data,” so that high-potential nodes can trigger deeper investigation. As frontier AI labs deploy agents toward scientific discovery, giving AI authentic scientific taste remains a trillion-dollar dilemma. The bottleneck is that the record we have kept for centuries of science might be insufficient to get us there. The experiments that never make the paper Peter Medawar, 1960 Nobel laureate and “father of transplantation,” asked in 1963 whether the scientific paper was a fraud, and answered yes: the form of the paper misrepresents the thinking that produced it. Sixty years on, the diagnosis is unchanged. A paper presents a clean progression from hypothesis to result to conclusion. Lost along the way are the unconventional theories, the abandoned or unaffordable methods, and the underwhelming and inconclusive data. It reads like a browser history with every dead end deleted: the ten open tabs, the four rephrased queries, the wrong turn down a subforum. All scrubbed, leaving one clean path from question to answer as the canonical path. What has changed since then is that the discarded material is now worth something. No high-impact journal wants these artifacts, but raw trial and error is the most likely source of the training data required to develop scientific intuition, or what researchers call taste. Earlier attempts to capture the discards were motivated by scientific integrity. The Journal of Negative Results in Biomedicine launched in 2002 to publish rigorous studies that disputed established models or exposed ineffective treatments. Its archive preserved negative conclusions after they had become papers, rather than the live alternatives and arguments that produced them. BioMed Central closed it in 2017, saying the mission had been served now that other journals publish null results. A less generous reading is that in fifteen years it published around 200 papers because almost nobody wants to read a negative result, let alone write one up when it will not count toward academic tenure. AI models are different. Even an uninteresting negative result can be useful, provided it is labeled. Earlier this year, Anthropic put a version of this to the test. The company pulled 129 decision points from real Claude Code sessions between January and March 2026, showed models the work up to a human detour, and asked what should happen next. Claude Mythos Preview beat the human choice 64% of the time, while Opus 4.5 managed 51%. The comparison was tilted toward the models because Anthropic deliberately chose moments where the human decision had room for improvement. On 127 further scenarios where the human action was already strong, the models improved on it only about 20% of the time. The study was possible because Anthropic’s researchers work inside a tool that logs by default. The reasoning, detours and outcome are produced in the same working environment. Biology has no equivalent. Its reasoning happens in hallways, at benches, in Slack threads and on whiteboards, while the outcome arrives weeks later somewhere else. The record has to emerge from the work itself. Ask scientists to reconstruct it afterwards and we’ll create another polished account. Subscribe A log is not a label Before any of this becomes training data, a negative result has to say what failed. The first paper published in the Journal of Negative Results in Biomedicine examined 234 negative studies across five leading medical journals. Only 30% discussed statistical power, and half clearly defined a primary outcome. Tell a model an experiment failed, without telling it whether the assay was underpowered, a reagent had degraded, or the hypothesis was simply wrong, and it will learn noise with confidence. Decision histories have a second missing label too. When a lab considers five experiments and runs one, only the chosen branch returns an outcome. The other four are experimental counterfactuals. Researchers call this the selective labels problem: the data reveal results only for the actions someone chose to take. Such a record can teach a model to imitate a lab’s taste, but it cannot establish that the taste was good. It also smuggles local constraints into general lessons. A lab that never ran cryo-EM because it did not own a microscope teaches a model that cryo-EM is rarely the right call. Alasdair’s nodes preserve the candidate set, which is the necessary first step. To be useful, each decision record needs six fields: The evidence available at that moment, and nothing that arrived later. The candidates considered, including the ones dismissed in a sentence. For each candidate: the expected result, the confidence attached to it, and the cost in time and money. The route chosen, and the reason. What happened next. How the evidence changed the scientist’s view. These must be timestamped before the outcome, because hindsight turns uncertainty into inevitability. Disagreement also has to survive. Averaging three scientists into one clean rationale reproduces exactly the information loss we are trying to fix. But there is an obvious failure mode here. Once decisions are logged and scored, people log for the record post-facto. Anyone who has watched an electronic lab notebook fill up with retrospective tidying knows how quickly a research tool becomes a compliance exercise. A record that costs a scientist ten minutes of honest reflection per decision is worth far more than one that costs an hour of performance. A publication initiative called Registered Reports offers a useful starting point. Here, researchers submit their rationale, methods and analysis plan for peer review before the data exist, and the journal commits in principle to publish if they follow the approved plan. Nature has now expanded the format across every field it covers. This approach to paper writing timestamps intent before the outcome, but it freezes one plan. A useful search history must also preserve how the plan changed, which alternatives were rejected, when, and on what evidence. Subscribe Run the runner-up Autonomous labs show what happens when decisions and outcomes are connected in a loop. Liverpool’s mobile robotic chemist ran 688 experiments over eight days in a ten-variable formulation space. A batched Bayesian search used each result to choose the next experiments and found photocatalyst mixtures six times more active than the starting formulations. Every completed experiment changed what the system did next. The robot optimized within a goal and search space that humans had already chosen. It did not decide which scientific question mattered. So what this work demonstrates is narrower, but still useful: a search history pays off when the options return standardized outcomes quickly. Open-ended biology is harder because branches can take weeks and the discarded alternatives may never be run. Some exploration therefore has to be bought. Where two branches are plausible and the stakes justify the cost, a lab should sometimes run the runner-up. Otherwise the record captures what today’s scientists usually chose and stays silent on what they systematically overlooked. A funder could ring-fence a small fraction of a grant for the branch not taken, provided that the decision record and the outcome are both deposited. That costs money, but so does having every lab rediscover the same abandoned path. Test whether taste transfers When it comes time to evaluate if our new AI system exhibits taste, the comparison should run across laboratories and fields. At selected decision points in a live research campaign, we should freeze the six fields: the evidence, the candidates, expected results, confidence, costs and the choice made. Experts then rank the options before the outcomes are known, and those outcomes are checked independently later. We could give models one of two diets - papers alone, or papers plus decision histories - and ask them to rank the next experiment on unfamiliar projects. Then, we score information gained per dollar and week, calibration, and how quickly weak branches are abandoned. If histories improve choices only inside the lab that produced them, they amount to useful organizational memory. If they improve choices on unfamiliar problems elsewhere, Alasdair’s group will have captured something science has never managed to write down: a transferable record of taste. Until that happens, a scientific search history is a promising record, not yet a training set.

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Aug 13 • 11:16 AM EDT • Science • press.airstreet.com
Middle Georgia skywatchers get a sunny science lesson, eclipse or not

Even without a solar eclipse overhead, skywatchers in Middle Georgia still found a way to join in the excitement Wednesday — with a little help from science, a

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Aug 12 • 8:50 PM EDT • Science • wgxa.tv
Asia-Pacific parliamentarians urge bolder action for universal health coverage, climate resilience and responsible AI

Parliamentarians representing 16 countries from across the Asia-Pacific region concluded the Ninth Meeting of the Asia-Pacific Parliamentarian Forum on Global Health (APPFGH) today, reaffirming their key role in advancing universal health coverage (UHC) amid the risks and opportunities posed by AI and climate change. In adopting the Phnom Penh Communiqué, parliamentarians urged fellow legislators regionwide to strengthen sustainable financing for UHC to widen access to health for all, including the most vulnerable populations; promote responsible governance of AI amid ethical concerns over this fast-evolving technology; and build climate-resilient health systems to anticipate and respond to mounting pressures ranging from rising sea levels in coastal areas to air pollution and other environmental degradation.The National Assembly of Cambodia, with support from Cambodia’s Ministry of Health and the World Health Organization (WHO), hosted the Forum in Phnom Penh from 11 to 13 August 2026 – the first time the Forum has convened in a Mekong country.Parliamentarians urge action to close gaps in accessIn the Communiqué, parliamentarians recognized that at-risk and marginalized groups are the ones most severely affected by gaps in access to health services. These groups include people living in poverty, women and children, persons with disabilities, older people, migrants, refugees, and those in rural, remote or island communities. The Communiqué urges fellow parliamentarians and policy-makers to advocate for laws and policies that support sustainable financing to protect people from financial hardship, with a focus on primary health care, prevention and equity. "The Communiqué is a call to action. It sets out ambitious, concrete measures that deliver meaningful impact on the ground. We are all accountable for advancing universal health coverage and translating our commitments into tangible results. Cambodia is fully committed to advancing UHC, including the promotion of ‘healthy people, prosperous country’ campaign,” said Samdech Maha Rathsapheathika Thipadei Khuon Sudary, President of the National Assembly of the Kingdom of Cambodia.His Excellency Professor Chheang Ra, Minister of Health of the Kingdom of Cambodia, highlighted the need for collaboration beyond the health sector. “Universal health coverage cannot be achieved by the Ministry of Health alone. It requires support, particularly from parliamentarians, across political, legislative, financial, social protection, education, infrastructure, and environmental domains. While each country follows its own path, one factor is universally critical for success: strong governance and leadership. We all believe in this principle, and in our respective political roles, we remain committed to strengthening these key success factors to ensure that no one is left behind.”Promoting responsible AI adoption Parliamentarians acknowledged that, while AI has already demonstrated its ability to improve access to health services and support delivery, careful and ethical governance is necessary to safeguard quality, safety, privacy and public trust. This underscores the importance of parliamentarians in promoting legal and regulatory frameworks addressing liability, records ownership and data governance, while embracing innovation that protects ethical practice.“Without strong governance, safeguards for privacy and data security, sustainable financing, and attention to those most at risk of exclusion, new technologies may widen existing gaps instead of closing them. This is why parliamentarians matter. We pass laws. We approve budgets. We scrutinize government action. We represent communities. We can ask whether health services are reaching rural, remote, ageing, poor, and marginalized populations. We can ask whether innovation is being guided by equity, evidence, and ethics,” said Hon. Man Hee Lee, President of the Asia-Pacific Parliamentarian Forum on Global Health.Building climate-resilient health systemsParliamentarians also reiterated that the climate crisis is a direct threat to people’s health and to achieving UHC more broadly, deepening the same gaps in access already faced by at-risk and marginalized communities. They recognized the need for WHO Member States to ensure sufficient national appropriations and oversight, and for parliamentarians to raise awareness in their constituencies and mobilize local action in building climate-resilient and sustainable health systems.“Universal health coverage, climate change and AI cannot be addressed in isolation. The same communities struggling to access health services today are often the ones most exposed to climate shocks, and most in need of the opportunities AI can offer if this technology is governed responsibly,” said Dr Saia Ma’u Piukala, WHO Regional Director for the Western Pacific. “Having served previously in this Forum myself as a parliamentarian from Tonga, I recognize how the Phnom Penh Communiqué reflects the shared resolve of legislators across the Asia-Pacific region: the laws parliamentarians pass and the budgets they approve help ensure this progress reaches the people who need it most.”As the Forum drew to a close, delegates reflected on what they would carry back to their own parliaments and constituencies.“I wish to share three points here worth carrying home from Phnom Penh: we need to invest in primary health care as the foundation of coverage; we need to remove the barriers that keep people from care, whether financial, geographic or social; and we need to build systems that are inclusive by design, protecting those most at risk of being left behind,” added Hon. Ouch Borith, First Vice-President of the Senate of the Kingdom of Cambodia.###Notes for editors:The Asia-Pacific Parliamentarian Forum on Global Health (APPFGH) is a platform for parliamentarians to exchange ideas, build political will, strengthen capacity and foster collaboration towards sustainable health action. This was the ninth meeting of the APPFGH, with the theme “Universal Health Coverage in the era of Climate Change and Artificial Intelligence”. Target 3.8 of the Sustainable Development Goals calls on countries to achieve universal health coverage, including financial risk protection, access to quality essential health services, and access to safe, effective, quality and affordable essential medicines and vaccines for all. In the Western Pacific, UHC service coverage index (SDG 3.8.1) rose from 63 in 2000 to 81 in 2023 (figures include Indonesia), and roughly one in four people in the Western Pacific have experienced financial hardship (SDG 3.8.2). Progress towards UHC in the Asia-Pacific region remains uneven, with hundreds of millions of people still lacking access to essential health services or facing financial hardship due to health-related expenses. Strengthening the role of parliaments – through legislation, financing and oversight – is central to closing this gap and accelerating progress towards UHC across the region.Parliamentarians participating in APPFGH in Cambodia this week include: Hon. Pehin Dato Adanan YUSOF, Brunei Darussalam; Hon. Rosmawatty ABDUL MUMIN, Brunei Darussalam; Hon. LORK Kheng, Kingdom of Cambodia; Hon. YOS Phanita, Kingdom of Cambodia; Hon. KHOUN Khundy, Kingdom of Cambodia; Hon. HENG Halim, Kingdom of Cambodia; Hon. KHOENG Noupheap, Kingdom of Cambodia; Hon. SENG Nhak, Kingdom of Cambodia; Hon. LY Sukry, Kingdom of Cambodia; Hon. NHOEURN Raden, Kingdom of Cambodia; Hon. Dr Ratu Atonio LALABALAVU, Republic of Fiji; Hon. Vijay NATH, Republic of Fiji; Hon. Man Hee LEE, Republic of Korea; Hon. Dr Jiho CHA, Republic of Korea; Hon. Jonghun BAEK, Republic of Korea; Hon. Youngsuk SEO, Republic of Korea; Hon. Dr Phayvanh KEOPASEUTH, Lao People’s Democratic Republic; Hon. Suhaizan Bin KAIAT, Malaysia; Hon. Dr Perpetua KONMAN, Federated States of Micronesia; Hon. Ganmaa DAVAASAMBUU, Mongolia; Hon. Charmaine SCOTTY, Republic of Naoero; Hon. Vincent Ambance KUMURA, Papua New Guinea; Hon. Dr Edwin CRUZADO, Republic of the Philippines; Hon. AUUAPAAU Mulipola Aloitafua Mulipola, Samoa; Hon. ASIATA TAVUI Tafu Salevao, Samoa; Hon. Dr Alani Petelo TANGITAU, Tonga; Hon. Paul PAOLO, Republic of Vanuatu; Hon. Franklyn Ezra WILLIAM, Republic of Vanuatu.For more information, contact: WHO Regional Office for the Western Pacific: wprocom@who.int National Assembly of the Kingdom of Cambodia (International Relations Department): ir.nacambodia@gmail.com

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Aug 12 • 8:00 PM EDT • Health • who.int
WIP not replacing Devan Kaney for Eagles broadcasts

WIP’s Philadelphia Eagles broadcasts will go into the 2026 NFL season without anyone specifically assigned to work the sidelines. Merrill Reese and Mike Quick, entering their 29th season calling games together, will lean on other WIP personalities for in-game updates instead of a dedicated reporter, according to the Philadelphia Inquirer’s Rob Tornoe. Per Tornoe, Eliot…

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Aug 12 • 5:40 PM EDT • Sports • sports.yahoo.com
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Cardiologists develop new anchoring technique for challenging TAVR cases

TAVR can be especially challenging in patients with PAR and an enlarged LVOT. Specialists in China have developed a new technique that could improve outcomes for some of these patients without introducing new risks.

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Aug 12 • 4:18 PM EDT • Business • cardiovascularbusiness.com
Panthers Might Be Without WR Xavier Legette For Preseason Opener

Carolina Panthers wide receiver Xavier Legette might not be playing in Saturday’s preseason game at the Buffalo Bills after suffering a stinger early in training camp.

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Aug 12 • 1:33 PM EDT • Sports • foxsports.com
Opinion: AI isn’t the business

AI will transform how businesses operate without replacing what makes them valuable.

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Aug 12 • 11:48 AM EDT • Business • fiercewireless.com
Storms leave over 729,000 homes and businesses without power in US Midwest

Over 729,000 homes and businesses were without power on Wednesday as severe ​storms battered the U.S. Midwest, according to ‌data from PowerOutage.us.

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Aug 12 • 8:28 AM EDT • Business • reuters.com
Arizona's wild horses deserve science, not assumptions

Arizona is reducing its wild horse herds toward targets set without real science. Officials should prove the numbers before removing more.

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Aug 12 • 8:01 AM EDT • Science • azcentral.com
Thousands face higher costs, go without health insurance after Essential Plan changes
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Aug 11 • 7:37 PM EDT • Health • 13wham.com
Lakers’ Marquee Matchups Revealed for First Season Without LeBron James

The Los Angeles Lakers' schedule comes out later on in the week, but the NBA has already unveiled some of the marquee games. The post Lakers’ Marquee Matchups Revealed for First Season Without LeBron James appeared first on LA Sports Report.

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Aug 11 • 5:43 PM EDT • Sports • sports.yahoo.com
Jenna Ortega would go ‘all day without eating or drinking’ as a kid on set to ‘not be in the way’

“I was so grateful and so excited to be there that my game face was on.”

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Aug 11 • 3:30 PM EDT • Entertainment • yahoo.com
Jenna Ortega would go ‘all day without eating or drinking’ as a kid on set to ‘not be in the way’

Jenna Ortega was so desperate to ‘not be in the way of anybody’ on set when she was a child actor that she would ‘go all day without eating or drinking.’

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Aug 11 • 3:30 PM EDT • Entertainment • ew.com
New images of the sun show its surface in the finest detail yet

It’s dangerous to look directly at the sun without proper eye protection. But researchers were able to peek at its scorching surface with the help of the National Science Foundation’s Daniel K. Inouye Solar Telescope.

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Aug 11 • 10:00 AM EDT • Science • latimes.com
College football realignment may not be done after late Protect College Sports Act provision

A 180-day grace period in the Protect College Sports Act could give Power Four schools a rare chance to change conferences without a five-year penalty.

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Aug 11 • 9:29 AM EDT • Sports • sports.yahoo.com
Politics & Power: Big opportunities, real risks, ethics & oversight as AI reshapes the legal industry

AI can make legal work faster, cheaper, and more accessible, but it doesn't come without risk. The organizations that come out ahead won't just be the ones that adopt the best tools. They'll be the ones that pair those tools with clear oversight, honest communication with clients, and a genuine commitment to getting it right.

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Aug 11 • 8:27 AM EDT • Politics • news4jax.com
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Red Sox score bizarre run on sacrifice fly without tagging up from 3rd base

Seigler scored a bizarre run for Boston in a 2-1 loss to the Blue Jays on a chaotic, inning-ending double play that resulted in a 17-minute delay as umpires sorted out the whole thing.

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Aug 11 • 7:35 AM EDT • Sports • spectrumlocalnews.com
Ocasio-Cortez faces a crossroads in politics

Rep. Alexandria Ocasio-Cortez (D-N.Y.) is at a career and life crossroads that many women face at the age of 36, even without the pressure of a potential White House run. The congresswoman, still l…

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Aug 11 • 6:00 AM EDT • Politics • thehill.com
Google is testing Search without the 'Google Search' button (Update: Confirmed)

A new version of the Google Search homepage has been spotted, and it removes the Google Search button to make room for AI tools.

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Aug 11 • 5:20 AM EDT • Technology • androidauthority.com
Spangler's poor health requires urgent testimony, judge rules

Attorneys for the indicted men and the state agree: Sheriff Tom Spangler, who is fighting pancreatic cancer, should testify under oath without delay.

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Aug 11 • 5:09 AM EDT • Health • knoxnews.com
Jeff Bezos Could Change Liverpool Without Spending on Players

A bid by Amazon founder Jeff Bezos to buy a stake in English Premier League club LIverpool FC could change it without spending on players. The post Jeff Bezos Could Change Liverpool Without Spending on Players appeared first on HEAVY.

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Aug 10 • 9:24 PM EDT • Sports • sports.yahoo.com
Over 41,000 Central Virginia homes, businesses without power amid severe storms

Over 41,000 Central Virginia homes and businesses are without power Monday evening as severe thunderstorms batter the region.

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Aug 10 • 6:52 PM EDT • Business • wric.com
Taylor Swift’s music quietly removed from social media posts from Trump campaign, White House accounts

In recent days, Taylor Swift’s music quietly disappeared from TikTok posts from the White House and “Team Trump” campaign accounts — without public condemnation, clapback or commenting from the singer.

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Aug 10 • 6:32 PM EDT • Politics • cnn.com
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Players lose access to Aliens: Fireteam Elite on Nintendo Switch without refunds

A reminder of the perils of digital ownership.

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Aug 10 • 5:26 PM EDT • Technology • arstechnica.com
Saber's newest game trailer takes a shot at Gearbox's CEO, if you look closely

The first hint that something might be up with the recent debut trailer for Saber Interactive’s Rideshare Stimulator is an unusual choice of words—aside from that second one in the game’s title. “Don’t take your passengers too seriously,” the trailer’s narrator says, as he describes this upcoming game. It a car game about the gig work of driving eccentric people to their destinations, a riff on Crazy Taxi. And then, he says: “When I think I’ve met the randiest of passengers, someone even stranger gets in.” “Randiest”? That suggests “randy,” which usually means having strong sexual desire. Yet none of the oddball backseat occupants featured in the trailer seem particularly lustful. One is an old man who considers his grandson a failure, another shares the theory that birds might control traffic lights, another says he’s banned from an aquarium. A little later, there’s a license plate, shown 63 seconds into the trailer, on the front of an SUV: USB DRV It’s a Texas plate. The symbol between those letters is a cog wheel. If you know, you know. That’s a reference to Texas-based Borderlands game development studio Gearbox Software (their logo features a cog wheel). More specifically, it’s a reference to Gearbox’s CEO Randy Pitchford, who in 2018 found himself explaining the nature of video he’d saved on a USB drive that was found at a Medieval Times restaurant before being returned to the studio: “It was ‘barely legal’ porn. This girl’s handle was ‘Only 18.’” The “girl” in the video had committed a solo sex act that Pitchford, an avid practitioner of magic, found remarkable. “I realized, this is not a sex worker…This is a fucking magician.” Back then, the USB drive was central to competing lawsuits against Gearbox by the studio’s former lawyer and by Gearbox against him. A settlement in late 2019 “exonerated” Pitchford, per the Hollywood Reporter. The USB story has resurfaced at times, now in a trailer from a company that not long ago was corporate brethren with Gearbox. Saber vs. Gearbox The head of Saber told Game File that the reference is payback. “The dig is because Randy took shots at Embracer in Borderlands 4,” Saber CEO Matt Karch told me when I asked him about the license plate. “Without Embracer, Randy is performing magic tricks at birthday parties for a living.” Having interviewed Karch during a cross-country flight in late 2024, I can confirm that Karch was unimpressed with Pitchford during their time both working in the Embracer group. I’d approached him not out of surprise that there was animosity but that it was manifesting publicly now. Gearbox was founded in 1999, worked on a port of Halo early on, and developed hit series such as the loot-based sci-fi shooter Borderlands before it was purchased by The Embracer Group in early 2021 for $363 million (with a possible earn-out of over $1 billion, if certain targets were hit by 2027). Saber was founded in 2001, worked on a remaster of Halo early on, had a big hit with zombie shooter World War Z and was purchased by Embracer in early 2020 for $150 million, with a potential earn-out of up to $375 million. For a few years, the Embracer group was a voracious acquirer of game studios. Then, as investment dried up, it choked. In March 2024, Embracer sold Saber to an investment company controlled by Saber CEO Matt Karch, and it sold Gearbox in an all-stock deal to long-time Borderlands publisher Take Two Interactive. Other studios were shut down. Hundreds of developers were laid off. Gearbox didn’t say much about their Embracer experience, nothing too direct, at least. In the summer 2024, Pitchford told reporter and occasional Game File contributor Nicole Carpenter that Borderlands 4’s story was in some way thematically connected to Gearbox’s experience at Embracer: “There’s this cultural and emotional shift in me, personally, and at the studio. What does it mean to trade some autonomy for organization?” When Borderlands 4 came out, there was something stranger: the matter of “Embracer’s Bluff,” a location in the game featuring an AI-powered toilet and a large trash dump, according to a detailed Kotaku account of the place. Gearbox never commented on it; Take Two never got back to me about it when I asked them last year. By contrast, since Saber exited Embracer, Karch has been one of Embracer’s biggest defenders, casting their management as well-meaning and supportive despite the layoffs and studio closures that resulted from their excessive expansion. Like others, Saber’s Karch saw Embracer’s as a shot. With Rideshare Stimulator’s trailer, he’s returned fire. “It’s amazing to me how fast people forget those who went above and beyond for them,” Karch told Game File. A rep for Gearbox did not comment by press time. Game File is a reader-supported publication. Your backing makes my reporting—including any coverage of trailer-based beefs—possible. Good news! I’m currently running Game File’s first big sale of 2026. You can get a one-year subscription for 23% off. Click here to take advantage of the limited-time offer. And thank you for your support! Item 2: In brief… 🚫 Wal-Mart has laid off the staff of Restart, a games media outlet launched in 2024, Aftermath reports. 🟥 A GTA VI preview is on the way, at last, via an “extended look” that will premiere, unusually, on Netflix at 3pm ET on August 27, then officially go live elsewhere six hours later. Last week, Game File noted that Take Two label Rockstar Games is overdue for showing off GTA VI, based on the timing of the initial hands-off previews of GTA V and Red Dead Redemption 2. During a call with investors, Take Two CEO Strauss Zelnick said pre-orders for GTA VI were “unprecedented and astonishing,” but added the company can’t predict how many of those pre-orders represent bonus sales vs. sales that otherwise would have been made at launch. During the same call, Zelnick was noticeably bullish on the future of playing games over streaming cloud connections (predicting wider adoption in three or so years). He sounded unbothered by Sony’s plans to stop making discs for new games (he said the business is 90% digital already and predicted that there could still be limited edition physical editions of games “in the same way there’s still vinyl in the recorded music business.”) 👀 Take Two wrote off $43 million in their spring quarter after deciding “not to proceed with further development of an unannounced title in its pipeline from a third-party developer.” 🤔 Some rare age-demographics from a big publisher: Capcom recently told investors that “users in their 20s account for approximately half of the users of both Pragamata and Resident Evil Requiem.” Item 3: The week ahead Tuesday, August 11 Game releases: The Elder Scrolls IV: Oblivion Remastered (Switch 2; already out for PC, PS5, Xbox) continues the Bethesda strategy of putting Elder Scrolls games on everything; Royalty Free-For-All is a Smash Bros.-style fighting game featuring public domain characters such as Mother Goose brawling with Oliver Twist in a stage based on the original Little Shop of Horrors movie. Wednesday, August 12 Game release: Pro Jank Footy (PC, console) is an arcade-style Australian Rules Football game with increasingly ridiculous rules, the more you play (I enjoyed the Steam demo) Thursday, August 13 Game release: Super Mario Sunshine (Switch 2, originally released in 2002 on the GameCube) is released for Switch 2’s Nintendo Switch Online service. This game is the black sheep of 3D Mario games. It’s the successor to the breakthrough Super Mario 64 and the rare Mario game built around a single (vacation resort) theme. Mario’s got a water-spraying backpack, a Yoshi pal and a lot of blue coins to collect.

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Aug 10 • 4:27 PM EDT • Technology • gamefile.news
California may fine content creators who don't disclose they were paid to post about politics

States are debating whether to crack down on social media influencers making political advertisements without disclosing that they were paid.

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Aug 10 • 3:50 PM EDT • Politics • kpbs.org
3 things to avoid in middle age could mean 13 more years without dementia, study finds

NYU Langone Health research reveals how avoiding high blood pressure, diabetes, and smoking in midlife could add nearly 13 dementia-free years.

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Aug 10 • 3:43 PM EDT • Health • foxnews.com
Bronny James faces pivotal Lakers season without LeBron on roster
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Aug 10 • 3:19 PM EDT • Sports • sports.yahoo.com
Before you throw out your old USB drives, do this first

How to perform a full format of your USB drive, how to destroy it and where to dispose of it. Don't just throw it in the trash without protecting yourself.

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Aug 10 • 1:30 PM EDT • Technology • engadget.com
When will Rohit Sharma make his TV debut? India star to feature in entertainment show on Sony

With Rohit Sharma set to appear on Sony TV, here's how you can grab his TV debut live without missing a single moment.

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Aug 10 • 12:58 PM EDT • Entertainment • yahoo.com
Aliens: Fireteam Elite on Nintendo Switch Shut Down With No Refunds, as Owners Become The Latest Victims of Gaming's Increasingly Digital Future

Aliens: Fireteam Elite has had its cloud servers shut down, leaving Nintendo Switch owners unable to play the game without any form of refund.

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Aug 10 • 11:58 AM EDT • Technology • ign.com
California may fine content creators who don't disclose they were paid to post about politics

States are debating whether to crack down on social media influencers making political advertisements without disclosing that they were paid.

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Aug 10 • 9:42 AM EDT • Politics • 10news.com
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AbCellera women’s health data top ‘most aggressive upside scenario,’ putting Astellas and Bayer on notice

AbCellera has reported phase 2 results “beyond even the most aggressive upside scenario” that its CEO dared to consider, boosting the biotech’s chances of challenging Astellas and Bayer for a women’s health market. The phase 2 clinical trial compared ABCL635, an antibody targeting NK3R, to placebo in patients with hot flashes caused by menopause. Investigators enrolled 92 postmenopausal women experiencing a mean of about 10 moderate or severe hot flashes per day. By Week 4, the number of moderate or severe hot flashes had fallen by a mean of 8.8 on ABCL635 and by 3.5 on placebo. That statistically significant, placebo-adjusted reduction of 5.3 hit the trial’s primary endpoint. The level of efficacy also cleared the bar set by existing drugs. While cross-trial comparisons can be misleading, AbCellera CEO Carl Hansen, Ph.D., had seen enough to start hyping the program. “We now view ABCL635 as a potential best-in-class non-hormonal therapy with strong differentiation against approved NK3R competitors across all important dimensions, including efficacy, safety, dosing and convenience,” Hansen said on a Monday morning conference call with investors to discuss the data. “We believe ABCL635 is now a highly de-risked program.” Last week, Hansen used AbCellera’s earnings call to set expectations for readout, with the CEO defining success as a clean safety profile and efficacy comparable to the two approved small molecules. The data vaulted over that bar. Astellas linked (PDF) one of the small molecules, Veozah, to placebo-adjusted reductions in hot flash frequency of 2.1 and 2.6 at Week 4 of its two phase 3 trials. Bayer reported (PDF) placebo-adjusted reductions of 3.04 and 3.29 at Week 4 of pivotal studies for its small molecule, Lynkuet. At 5.3, the placebo-adjusted reduction in AbCellera’s trial comfortably cleared the standard set by the incumbents. Veozah and Lynkuet came to market based on evidence of their ability to reduce the frequency and severity of hot flashes. AbCellera’s phase 2 study covered both endpoints, with the Canadian biotech reporting a mean reduction in severity of 1.4 points at Week 4 on ABCL635, compared to 0.3 points for placebo. Again, the placebo-adjusted result compares favorably to data on Veozah and Lynkuet. Analysts shared Hansen’s enthusiasm for the data. The phase 2 results “firmly validate ABCL635 as a potentially best-in-class treatment,” BMO Capital Markets analysts said in a note to investors Monday. ABCL635’s apparent efficacy edge “is likely attributable to the higher dosing/target engagement the asset is able to reach vs. the oral agents due to its wider therapeutic index,” the analysts added. The analysts, who model $2.3 billion in unadjusted peak sales for ABCL635, flagged the safety profile as another positive of the phase 2 readout. While Veozah carries a boxed warning for liver damage, nobody on ABCL635 in the phase 2 trial had elevated liver enzymes or bilirubin values. If replicated in phase 3, the lack of a liver signal could allow approval without the monitoring requirements imposed on Veozah. Investors appeared equally enthused, sending AbCellera's stock up 32% to $9.21 in premarket trading Monday from a Friday closing price of $6.93. Next, AbCellera will collect the Week 12 data and talk to its advisors about further development. The results open up “a wide variety of possibilities of how we might take this forward into phase 3 studies to truly maximize the value of the asset and make sure that ABCL635 is able to demonstrate its differentiation potential,” Sarah Noonberg, M.D., Ph.D., AbCellera’s chief medical officer, told investors.

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Aug 10 • 8:24 AM EDT • Health • fiercebiotech.com
Socialists Need to Develop a Constitutional Politics

To win change for working people, the Democratic Socialists of America should expand its vision of how to change our constitutional order. We can smash unaccountable executive and judiciary power even without having to amend the Constitution.

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Aug 10 • 8:00 AM EDT • Politics • jacobin.com
RFK Jr. slated to unveil plan targeting loophole that allows chemicals in food supply

The practice known as “generally recognized as safe” allows companies to self-certify the safety of certain food chemicals or substances without strict government oversight.

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Aug 10 • 6:00 AM EDT • Health • washingtonpost.com
Digital Science launches Dimensions MCP servers

Existing Dimensions API customers can begin using the Model Context Protocol servers immediately without extra licence

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Aug 10 • 5:00 AM EDT • Science • researchinformation.info
Windows 11's Built-In Weather App Wastes More Than 1 GB of RAM

According to Windows Latest, the default weather application in Windows 11 can consume more than 1 GB of RAM just by displaying the weather forecast. When the Weather application is open, it uses nearly 1.2 GB of RAM, even without any scrolling, clicking, or other interactions. By default,...

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Aug 10 • 4:57 AM EDT • Technology • techpowerup.com