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Idaho shouldn’t order my business how to organize bathrooms

And business owners would be forced to do what, exactly? Remodel their bathroom structure? Will the government be paying? | Opinion

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Apr 1 • 6:00 AM EDT • Business • idahostatesman.com
Georgia lawmakers tackle childhood literacy as session nears end

Georgia lawmakers have made progress on issues like property tax relief and childhood literacy, but there’s still plenty of work to be done before they adjourn Thursday.

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Apr 1 • 5:00 AM EDT • Politics • ajc.com
A messy California governor's race raises Democratic fears of potential loss

Democrats have run California for years

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Apr 1 • 12:24 AM EDT • Politics • washingtonpost.com
Vance and Rubio's differing postures on Iran war highlight their challenges ahead of 2028 election

Secretary of State Marco Rubio and Vice President JD Vance are both seen as the Republican Party’s strongest potential candidates in the next presidential election, but the Iran war could prove to be a political millstone for them

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Apr 1 • 12:12 AM EDT • Politics • washingtonpost.com
Subprime Lender Goeasy Sees Elevated Writeoffs Before Business Improves

Subprime lender Goeasy Ltd., which surprised investors weeks ago with a surge of bad debts in its vehicle financing business, said it expects loan writeoffs to remain elevated for a while before getting better later in the year.

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Mar 31 • 9:45 PM EDT • Business • bloomberg.com
Sentiment improves among Japan's big firms, but Iran war clouds outlook

Business ​sentiment among large Japanese manufacturers improved in the three months to ‌March, according to a closely watched survey released on Wednesday, a sign that increasing economic uncertainty from the Middle East conflict has yet to hit morale.

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Mar 31 • 8:18 PM EDT • Business • reuters.com
Bruce Springsteen launches political U.S. tour with 'Streets of Minneapolis'

The New Jersey rocker released “Streets of Minneapolis” in late January amid the nationwide outcry over the shooting deaths of Renee Good and Alex Pretti by federal officers.

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Mar 31 • 7:23 PM EDT • Politics • pbs.org
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The Clippers look dangerous + WNBA expansion draft preview
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Mar 31 • 1:41 PM EDT • Sports • sports.yahoo.com
Savannah State University opens new Stem E-Sports Lab

The grand opening is set for April 1 at 11:30 a.m. in Hubert Science and Technology Building A, room 104, on the SSU campus.

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Mar 31 • 10:30 AM EDT • Sports • wtoc.com
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Scientists Investigating Whether Object NASA Is Approaching Is Core of Destroyed Planet

Scientists are trying to figure out how "the pizzas were made."

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Mar 31 • 9:05 AM EDT • Science • yahoo.com
Microsoft is bringing the best of Windows Terminal to Windows 11's native Command Prompt

Console Host is gaining several features that have been available on Windows Terminal for a while, including better graphics support, scrolling performance improvements, and more.

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Mar 31 • 5:32 AM EDT • Technology • windowscentral.com
Midnight Mania! ‘I’m All In On RAF’

Bringing you the weird and wild from the world of MMA each and every weeknight!

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Mar 30 • 11:59 PM EDT • Sports • sports.yahoo.com
Oil rises for a fourth day on supply cuts from widening Middle East conflict

Oil prices rose for ​a fourth day on Tuesday, with Brent crude poised for its largest monthly gain on record and U.S. ‌crude futures set for their strongest monthly increase since 2020, because of supply constraints from the widening Middle East war.

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Mar 30 • 9:12 PM EDT • Business • reuters.com
Governor’s race accusations roil an already tense legislative session

Two House Republicans backing billionaire Rick Jackson are now openly accusing Lt. Gov. Burt Jones of bottling up their bills in retaliation for endorsing his rival.

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Mar 30 • 9:48 AM EDT • Politics • ajc.com
Scientists Just Upended a 300-Year-Old Law of Physics

When load increases steadily, so does friction, but in the realm of magnetization dynamics, things aren’t so simple.

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Mar 30 • 9:30 AM EDT • Science • yahoo.com
Oliver Bearman’s ‘scary’ crash punctuates concerns over new F1 regulations

Haas driver Oliver Bearman’s ‘scary’ crash at the Japanese Grand Prix has F1 drivers calling for change

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Mar 30 • 8:59 AM EDT • Sports • sports.yahoo.com
AP Decision Notes: What to expect in Arkansas' primary runoff elections

Two Arkansas Republicans with competing visions on how best to implement President Donald Trump’s agenda to overhaul elections and voting will vie for their party’s nomination for the state’s top elections job on Tuesday

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Mar 30 • 8:31 AM EDT • Politics • washingtonpost.com
She owed her insurer a nickel, so it canceled her coverage

When medical bills started rolling in, a teacher’s aide wondered why her insurance suddenly wasn’t covering them.

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Mar 30 • 5:00 AM EDT • Health • washingtonpost.com
Hornets’ Charles Lee hilariously dismisses ‘not that good’ Derrick White

Hornets HC Charles Lee joked around with Derrick White, whom he helped coach to a title when he was with the Celtics in 2024.

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Mar 29 • 11:07 PM EDT • Sports • sports.yahoo.com
Mid-Ohio Valley Spring Sports: Williamstown Yellowjackets schedule

Baseball Head coach: Levi Maxwell Assistant coaches: Ryan Scott, Mark Adkins, Matt Houser, Cole MacIver, Josh Yearego Roster Seniors Wyatt Powell, Dylan Pucella Juniors Wyatt Siley, Austin McDonald Sophomores Breck Allen, Jackson Fulton, Noal Powell, Jacob MacIver Freshmen Ben Raines, Brayden Strcula, Colten Rinard, Daniel Cunningham, Zander Brookover, Alexander Schmidt Schedule March 23: at Doddridge […]

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Mar 29 • 8:00 PM EDT • Sports • newsandsentinel.com
Midnight train from Georgia: A view of America from the tracks as airports struggle in the shutdown

Long security lines at airports are driving people crazy as Congress and President Donald Trump try to work out a budget stalemate

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Mar 29 • 2:11 PM EDT • Politics • washingtonpost.com
Washington Commanders Open to Adding 6x All-Pro
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Mar 29 • 1:48 PM EDT • Sports • sports.yahoo.com
'Project Hail Mary' flies to $54.5 million second weekend, horror reaches a saturation point

a e n horror theater entertainment scifi-and-fantasy movies u-s-news general-news | 100.1 FM and AM 1020 KDKA

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Mar 29 • 12:12 PM EDT • Entertainment • audacy.com
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Doris Kearns Goodwin shares lessons for today's politics

Presidential historian Doris Kearns Goodwin spoke at Assumption University, sharing lessons from history for today's political landscape.

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Mar 29 • 11:58 AM EDT • Politics • telegram.com
Jorge Mateo gets first Braves start in series finale

The Braves are looking to close their first series with a sweep.

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Mar 29 • 11:18 AM EDT • Sports • sports.yahoo.com
Actor James Tolkan of 'Top Gun' and 'Back to the Future' fame dies at 94

a e n movies entertainment celebrity u-s-news general-news | 100.1 FM and AM 1020 KDKA

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Mar 28 • 4:56 PM EDT • Entertainment • audacy.com
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And then Jamal Murray had a 31-point, 14-assist …

And then Jamal Murray had a 31-point, 14-assist …

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Mar 28 • 7:28 AM EDT • Sports • sports.yahoo.com
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4 weeks in, Trump’s conflicting signals on Iran war frustrate GOP lawmakers and political allies

President Donald Trump’s conflicting signals over the future of the war in Iran have spurred deepening frustration among GOP lawmakers and allies who fear the administration still lacks a clear endgame after four weeks of fighting.

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Mar 28 • 6:00 AM EDT • Politics • cnn.com
The cockfighting business on the border: Illegal breeding farms in the US and birds sold for thousands of dollars to cartels in Mexico

An investigation by two NGOs indicates that some of the main breeders of fighting birds have operations in both countries and supply hundreds of thousands of specimens to criminal organizations each year

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Mar 28 • 12:00 AM EDT • Business • english.elpais.com
DHS shutdown drags on after House passes 'dead on arrival' bill

The House-passed bill is doomed in the Senate, which is on a scheduled recess.

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Mar 28 • 12:00 AM EDT • Politics • usatoday.com
Kansas Senate passes bill to create sports authority for future Chiefs stadium

The Kansas Senate passed a bill to create a sports authority, a board that would oversee a new stadium in Kansas City, Kansas, and a team headquarters in Olathe.

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Mar 27 • 10:41 PM EDT • Sports • kctv5.com
Cam Schlittler, Yankees dominate Giants for second straight shutout

Aaron Judge and Giancarlo Stanton provided the punch to back a pitching clinic by the Cove.

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Mar 27 • 7:31 PM EDT • Sports • sports.yahoo.com
Trump says 'Cuba is next' in speech touting U.S. military successes

President Donald Trump on Friday said "Cuba is next" during a speech at an investment forum in Miami during which he touted the successes of U.S. military action in Venezuela and Iran.

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Mar 27 • 7:23 PM EDT • Politics • detroitnews.com
WATCH: Johnson rejects Homeland Security funding bill passed by the Senate as a 'joke'
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Mar 27 • 4:08 PM EDT • Politics • pbs.org
Ashley Benson Signs With Strand Entertainment

EXCLUSIVE: Strand Entertainment has signed Ashley Benson, an actress and producer whose work spans studio features, independent film, and television, for management. Benson was most recently seen star...

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Mar 27 • 12:03 PM EDT • Entertainment • nz.news.yahoo.com
NFL Draft Injury Analysis: Caleb Tiernan, OT

Caleb Tiernan, OT medical report

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Mar 27 • 9:56 AM EDT • Sports • sports.yahoo.com
A Grip on Sports: As we prep for a weekend full of college hoops and searching for the next M's game, we had to take a little time to look back at a disappointing Opening Day

A GRIP ON SPORTS • Why do the Mariners do this to us so often?

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Mar 27 • 4:38 AM EDT • Sports • spokesman.com
New bill aims to keep professional sports teams in their home city

A new bill would make it more difficult for professional sports team owners to relocate their franchises by giving communities the right of first refusal.

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Mar 26 • 9:50 PM EDT • Sports • wafb.com
New bill aims to keep professional sports teams in their home city

A new bill would make it more difficult for professional sports team owners to relocate their franchises by giving communities the right of first refusal.

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Mar 26 • 9:50 PM EDT • Sports • localnewslive.com
Apple Discontinues Mac Pro Desktop in Favor of the Mac Studio

Apple Inc. on Thursday discontinued the Mac Pro desktop, its highest-end computer aimed at video editors, photographers and other advanced users.

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Mar 26 • 5:23 PM EDT • Technology • bloomberg.com
Frame Art & Design celebrates 30 years of business

Frame Art & Design is celebrating more than 30 years of expert framing and fine art services.

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Mar 26 • 6:30 AM EDT • Business • inputfortwayne.com
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Photos: Best images from Thunder's 119-109 loss to Celtics

The best photos from the Oklahoma City Thunder's 119-109 loss to the Boston Celtics.

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Mar 25 • 11:46 PM EDT • Sports • sports.yahoo.com
Trump envoy credits colorful rhetoric and vodka shots in helping him build bond with Belarus leader

President Donald Trump’s special envoy to Belarus recently revealed how he used vulgarity and vodka shots to help ingratiate himself with the country’s autocratic leader

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Mar 25 • 7:18 PM EDT • Politics • washingtonpost.com
Student-led business hooks customers across the country

Stay up to date with the latest news, stories, and achievements from the Susquehanna University community.

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Mar 25 • 3:49 PM EDT • Business • susqu.edu
Afeela EVs Really Are Vaporware. Sony, Honda Kill Entertainment-Focused Car

Sony's plans depended on technology from three upcoming Honda models. When Honda cancelled those EVs, Sony did 'not have a viable path forward' on Afeela.

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Mar 25 • 11:53 AM EDT • Entertainment • pcmag.com
New records in Trump documents case raise concerns over business conflict, US lawmaker says

Newly released records in the now-dismissed classified documents case against U.S. President Donald Trump raise fresh concerns over national security risks and potential private business motivations, the top ​Democrat on the House Judiciary Committee said.

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Mar 25 • 11:37 AM EDT • Business • reuters.com
Critically endangered hare spotted in surprising location for the first time in 40 years — but it was already dead

Scientists in China have announced the first confirmed sighting of the critically endangered Hainan hare in part of its native range in four decades, after spotting its completely flattened carcass on a roadside.

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Mar 25 • 10:38 AM EDT • Science • livescience.com
These 7 players will define the 2026 fantasy baseball season
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Mar 25 • 10:08 AM EDT • Sports • sports.yahoo.com
Spring sports heat up Tuesday night in the Heartland

The Cape Central Girls Soccer team played its home opener against St. Vincent, while the Notre Dame Boys Baseball team hosted Portageville on Tuesday.

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Mar 25 • 12:01 AM EDT • Sports • kfvs12.com
Scientists discover mirror of our solar system in 2 exoplanets forming around a star

Astronomers have spotted two planets forming around a distant infant star, offering a time capsule into see what the solar system looked like billions of years ago.

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Mar 24 • 5:00 PM EDT • Science • yahoo.com
Lavonte David retires after 14 seasons with Tampa Bay Buccaneers
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Mar 24 • 1:40 PM EDT • Sports • sports.yahoo.com
Standout safety reclassifies to 2027, recruitment picking up

One of the top safeties in the 2028 class has opted to reclassify to the 2027 class with his recruitment picking up steam.

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Mar 23 • 9:22 PM EDT • Sports • sports.yahoo.com
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The Monday Outlook: Project Hail Mary and the Science Behind Blockbuster Sci-Fi

Project Hail Mary is the latest sci-fi blockbuster to stretch the bounds of audience imagination and stir the curiosity of real scientists. But the science driving films like Project Hail Mary, Interstellar and The Martian isn’t all fictional: at UChicago, researchers exploring the cosmos and decoding the origins of life are making discoveries that would feel right at home on the big screen. This week's Monday Outlook features scientists from UChicago and Argonne National Laborat

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Mar 23 • 6:35 PM EDT • Science • newswise.com
10 Surprising Perimenopause Symptoms That Are More Common Than Hot Flashes, According to New Research

Think perimenopause is just about hot flashes? Check out these very common other menopause symptoms.

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Mar 23 • 8:00 AM EDT • Health • health.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Cuba Says Its Military Is Prepared as Trump’s Threats Multiply

A senior Cuban official said the country is preparing for a possible military assault as President Donald Trump increases economic pressure on the government in Havana and suggests it could be the next US target after Venezuela and Iran.

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Mar 22 • 9:00 AM EDT • Politics • bloomberg.com
A Grip on Sports: In a season when Gonzaga's defense was the driving force behind its success, the Zags couldn't get the one stop they needed

A GRIP ON SPORTS • After all the flotsam and jetsam is swept away, sometimes a college basketball game, an NCAA Tournament game, comes down to making one play. Saturday night in Portland, Texas did. And Gonzaga’s season once again fell short of its ultimate goal.

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Mar 22 • 3:16 AM EDT • Sports • spokesman.com
Arizona softball walks off ASU to even series

Arizona softball earned a walk-off win over ASU Saturday night, though not the kind the Wildcats may have been expecting through the first part of the game. Arizona jumped out to an 8-0 lead, then allowed the Sun Devils to claw all the way back before Regan Shockey delivered a walk-off single in the seventh […]

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Mar 22 • 1:10 AM EDT • Sports • sports.yahoo.com
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NCAA tournament takeaways, Day 2: Kentucky survives on buzzer-beater, Miami (Ohio) exits and Iowa State loses Joshua Jefferson
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Mar 21 • 1:01 AM EDT • Sports • sports.yahoo.com
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NVIDIA DLSS 5 Takes 2D Frame and Motion Vectors as Input

The public is still learning more about DLSS 5 technology, and NVIDIA is gradually revealing additional details. In a conversation between YouTuber Daniel Owen and NVIDIA's GeForce Evangelist Jacob Freeman, we discover that DLSS 5 essentially takes 2D frames and motion vectors as input, applying its...

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Mar 20 • 1:08 PM EDT • Technology • techpowerup.com
I've been a neuroscientist for 20 years. I keep my brain strong and healthy by avoiding 6 things

UCLA professor and neuroscientist Dr. Alex Korb shares the the habits he avoids to help strengthen his brain and manage his stress.

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Mar 20 • 12:00 PM EDT • Health • cnbc.com
Jefferson Health hit with $108 million verdict in Einstein birth injury case

The verdict is the biggest medical malpractice verdict in the city since a record-setting $183 million award against Penn Medicine three yeas ago in another birth-injury case.

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Mar 20 • 8:50 AM EDT • Health • inquirer.com
A Grip on Sports: The Zags survive a first-round rock fight in Portland, one that also caused contusions for those watching from home

A GRIP ON SPORTS • There was one thing I was certain of when I began writing this column almost 15 years ago. The day Chuck Norris died, I would share my story of the lone interaction I had with the “Walker, Texas Ranger” star. It has everything. High school football. A rickety press box. Family. Sports writing. But, alas, it may have to wait. Today is just not the day.

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Mar 20 • 4:49 AM EDT • Sports • spokesman.com
What’s March Without the Madness? Good for NCAA Business

March Madness is losing much of what made it mad.

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Mar 19 • 10:14 AM EDT • Business • bloomberg.com
Leading Chinese remote-sensing scientist Zhang Jinshui dies at 47

Beijing Normal professor led major R&D programmes and was instrumental in enhancing the country’s food security with satellite technologies.

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Mar 19 • 2:00 AM EDT • Science • scmp.com
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Jaylen Waddle trade shakes up Denver Broncos wide receiver room

What the Denver Broncos trade for Jaylen Waddle means to their wide receiver room.

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Mar 18 • 6:00 AM EDT • Sports • sports.yahoo.com
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Nebraska football commit invited to renown quarterback competition

Nebraska quarterback commit Trae Taylor earned an invitation to the Elite 11 Finals in Los Angeles following his play at the Dallas Regional.

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Mar 17 • 5:08 AM EDT • Sports • sports.yahoo.com
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Devils Rally Past Bruins in OT

It’s nights like these that make you wonder, what could have been. The New Jersey Devils certainly didn’t look like the hapless, directionless mess of a hockey team that spent the past three-plus months struggling to get out of its own way while plummeting to the darkest depths of the Eastern Conference standings. Well, maybe […]

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Mar 16 • 11:48 PM EDT • Sports • sports.yahoo.com
Buc-ee’s gets F rating from Better Business Bureau. Here’s why

The giant Texas convenience store, known for its brisket, beaver nugget snacks and clean gas station bathrooms, recently received an “F” rating at many of its...

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Mar 16 • 1:46 PM EDT • Business • dallasnews.com
How Healthy Is Corned Beef?

This St. Patrick's Day staple isn’t exactly good for you, but it still offers some nutritional benefits. Here’s what to know.

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Mar 16 • 8:00 AM EDT • Health • health.com
The New York Times

Gun-rights activists are a long-established force in Republican politics. But no candidate with a credible chance of reaching Congress has had a profile quite like Brandon Herrera, who has built a...

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Mar 16 • 7:00 AM EDT • Politics • facebook.com
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GN Store Nord to sell hearing business to Amplifon for $2.6 billion

GN Store ​Nord has ‌agreed to sell ​its Hearing ​business to Italy's ⁠Amplifon ​for 17 ​billion Danish crowns ($2.6 billion) ​on ​a cash-free and ‌debt-free ⁠basis, the Danish hearing aid ​maker ​said ⁠on Monday.

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Mar 16 • 4:10 AM EDT • Business • reuters.com
Inside MPTF's Star-Studded 'Night Before' Oscars Party — Including an Exclusive Performance and an Attention-Getting Photobooth

PEOPLE Editor-in-Chief and General Manager Charlotte Triggs takes you inside the A-list-packed party hosted by the Motion Picture & Television Fund. See all the stars mingling the night before the Academy Awards and get a look at the glam-bot booth in support of Novartis' "Your Attention, Please" campaign in support of breast cancer screenings.

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Mar 15 • 5:35 PM EDT • Entertainment • people.com
Suns lookahead. Phoenix continues six-game road trip against Celtics

Phoenix Suns are on a six-game road trip that began with a March 10 win over the Milwaukee Bucks.

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Mar 15 • 8:00 AM EDT • Sports • sports.yahoo.com
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Hundreds of students compete in Science Olympiad regional at Rock Valley College

Hundreds of middle school and high school students spent Saturday at Rock Valley College to put their science skills to the test during the annual Science Olympiad regional competition.

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Mar 14 • 10:27 PM EDT • Science • wifr.com
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NFL news, free agency updates: Titans reportedly keeping WR Calvin Ridley on restructured deal; QB Trey Lance signs with Chargers
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Mar 14 • 6:47 PM EDT • Sports • sports.yahoo.com
Browns Newest LB Used Crazy Analogy to Describe his Play

Quincy Williams opens up about his history with new Cleveland Browns DC Mike Rutenberg and how he fits in the team's aggressive defense

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Mar 14 • 2:41 PM EDT • Sports • sports.yahoo.com
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Broncos Country underwhelmed by Broncos free agency moves

Based on results of our FanDuel SB Nation Reacts survey earlier this week, it is pretty clear what Denver fans think of the team signing ONLY Broncos free agents. Not thrilled. At the time of the survey, the Broncos had re-signed Alex Palczewski, Adam Trautman, Alex Singleton, Nate Adkins, and Justin Strnad. Since then, they […]

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Mar 14 • 7:00 AM EDT • Sports • sports.yahoo.com
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Maple Leafs star Auston Matthews out for season after 'dirty' hit, Ducks' Radko Gudas gets 5-game suspension
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Mar 13 • 8:58 PM EDT • Sports • sports.yahoo.com
Fans gather for Dolly Parton's return post-health struggle

NBC News' Kathy Park stopped by Dollywood’s opening day — which marks Dolly Parton’s first public appearance since announcing health struggles last year. 18,000 people lined the walkways waiting to catch a glimpse of Dolly during the parade.

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Mar 13 • 5:51 PM EDT • Health • nbcnews.com
High-Signal Publisher
Direct-to-consumer health gets a jolt

DTC plays are being revitalized by investor demands for credible margins.

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Mar 13 • 4:34 PM EDT • Health • axios.com
High-Signal Publisher
Adams County Fair announces entertainment lineup with Hairball, Trace Adkins, Wyatt Flore

Hairball, Trace Adkins and Wyatt Flores headlining this season

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Mar 12 • 11:28 PM EDT • Entertainment • ksnblocal4.com
Google just gave Gemini the power to control apps on the Galaxy S26 — and it's pretty wild

The new feature lets Gemini order food, book rides, and navigate apps for you.

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Mar 12 • 5:19 PM EDT • Technology • androidcentral.com
Honda expects FY2025/26 loss of up to $4.3 bln from review of EV strategy

Honda Motor ​revised down ‌its earnings forecast ​to a ​loss of 420 ⁠billion ​yen to ​690 billion yen ($2.6 billion to $4.3 ​billion) ​in the financial year ‌ending ⁠this month due to ​reassessment ​of ⁠its electrification strategy, ​the ​company ⁠said on Thursday.

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Mar 12 • 2:46 AM EDT • Business • reuters.com
Free Agency Recap

Doug breaks down every meaningful reported free-agent signing from the first day of the new league year.

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Mar 12 • 2:26 AM EDT • Sports • sports.yahoo.com
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Best Bookkeeping Software for Small Business (2026): Sage Awarded for Streamlined Recordkeeping by Better Business Advice

Better Business Advice has recognized Sage in its 2026 assessment of the best bookkeeping software for small business, highlighting the platform's structured approach to digital recordkeeping, automation, and financial visibility.

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Mar 11 • 10:30 AM EDT • Business • finance.yahoo.com
Xbox hardware teased at GDC, just one week after PC/console hybrid Project Helix was first confirmed

Microsoft has posted a set of photos giving us a small teaser for some unspecified work-in-progress Xbox hardware.

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Mar 11 • 6:55 AM EDT • Technology • eurogamer.net
Cowboys interested still interested in Maxx Crosby after failed physical

There’s potential for Dallas to renege on the Rashan Gary trade up until tomorrow, the start of the new league year

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Mar 10 • 8:39 PM EDT • Sports • sports.yahoo.com
Pittsburgh Steelers, Michael Pittman trade details revealed

Trade terms emerge on the Steelers’ acquisition of Michael Pittman.

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Mar 10 • 12:20 PM EDT • Sports • sports.yahoo.com
‘Be Amazing’ business-supported fundraiser to be held Thursday

More than 50 businesses are participating the 9th ‘Dine out and Shop Around’ fundraiser for Be Amazing.

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Mar 10 • 11:15 AM EDT • Business • wsaw.com
Dear Abby: I’m sure friend is milking her health issue for fraudulent GoFundMe money. Should I report her?

She opened a new fundraising page with an untrue sob story about her cancer returning and being hospitalized about a week.

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Mar 10 • 3:04 AM EDT • Health • oregonlive.com
Initial Thoughts on the Vikings’ Free Agency Moves

The Minnesota Vikings were not big players in the first day of the ‘legal tampering period’ which has become essentially the first day of free agency as a torrent of deals are announced. The Vikings did make some big splashes in free agency last year, and the dead cap hits to clear those moves is […]

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Mar 9 • 10:22 PM EDT • Sports • sports.yahoo.com
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Ashley Judd Says 'Kiss the Girls' Uses Sexual Torture as Entertainment

Ashley Judd is calling out her own movie, 1997's 'Kiss the Girls,' for 'making entertainment out of sexual terror' and show male sexual violence.

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Mar 9 • 5:46 PM EDT • Entertainment • variety.com
NFL news, free agency updates: Steelers trade for Michael Pittman Jr.; Travis Etienne reportedly joining Saints, Kenneth Walker to sign with Chiefs; Dolphins sign Malik Willis
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Mar 9 • 2:10 PM EDT • Sports • sports.yahoo.com
Samsung promises 120 games will be playable via its glasses-free 3D monitor tech by the end of the year

Samsung just announced that 120 games will be playable via its Odyssey 3D Hub platform by the end of the year. This is the platform that allows for glasses-free 3D gaming on Odyssey monitors.

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Mar 9 • 2:01 PM EDT • Technology • engadget.com
Nintendo sues the Trump administration over 'unlawful' tariffs

Nintendo has filed suit over Donald Trump's 'unlawful' tariff measures against the U.S. government, from which it is demanding a 'refund with interest' on all additional duties paid.

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Mar 8 • 11:24 PM EDT • Entertainment • ew.com
Jennifer Runyon Corman, 'Charles in Charge' actress, dies at 65

Jennifer Runyon Corman, known for her role as Gwendolyn Pierce on the classic sitcom 'Charles in Charge,' as well as appearances in 'Ghostbusters' and 'Up The Creek,' has died at 65.

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Mar 8 • 11:05 PM EDT • Entertainment • ew.com
How America’s nursing shortage impacts health care

Demand for nurses expected to continue through 2038

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Mar 8 • 11:00 PM EDT • Health • deseret.com
2026 NFL Draft big board: Ohio State's Caleb Downs is No. 1 among top 50 prospects
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Mar 8 • 4:15 PM EDT • Sports • sports.yahoo.com
In a rough labor market, hiring in healthcare is a consistent bright spot

The proliferation of health provider and care worker jobs is supporting what little growth exists in the labor market right now.

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Mar 8 • 12:15 PM EDT • Health • finance.yahoo.com