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Apple’s big goal after foldable iPhone
The first critical step for new CEO John Ternus be to make AI an everyday reality on its devices
For these Midwest farmers, regenerative agriculture is about more than soil health. It's spiritual
The towering maple trees and native hazelnut bushes on Salvatierra Farms break up the surrounding corn and soybean fields that sprawl across southern Minnesota.
US Open predictions and expert picks for tournament's semifinal round
From tournament favorites and proven champions to dark horses, our experts give their takes on the men's and women's draws with semifinal predictions.
Trump’s $5K dividend proposal if Republicans win midterms draws mixed reactions
During the GOP convention, the president said all U.S. adults would receive $5,000 if Republicans maintain House and Senate control
Trump’s $5K dividend proposal if Republicans win midterms draws mixed reactions
During the GOP convention, the president said all U.S. adults would receive $5,000 if Republicans maintain House and Senate control
Trump’s $5K dividend proposal if Republicans win midterms draws mixed reactions
During the GOP convention, the president said all U.S. adults would receive $5,000 if Republicans maintain House and Senate control
Kings of Leon reveal a new more personal, acoustic songwriting direction with album 'O My Beloved'
Kings of Leon are returning with a new album, “O My Beloved,” which marks a sonic shift for the band. Frontman Caleb Followill broke his foot playing tag with his kids, leading to a creative...
Oakland is borrowing SF’s playbook to revive struggling downtown
While perceptions around public safety have begun to shift in Oakland, organizers say the city has yet to see the rebound in activity that is taking place across the Bay.
Supreme Court blocks Missouri’s attempt to use newly drawn Republican congressional map
Missouri Secretary of State Denny Hoskins had sought to use the new Republican map despite the Missouri Supreme Court saying that he is barred from doing so.
Amazon gives OpenAI's ad business a boost, letting its advertisers into ChatGPT
Amazon has been hesitant to open its sprawling webstore to external AI platforms.
FTC withdraws health app data breach notification policy
The Federal Trade Commission has rescinded a policy statement that previously extended federal data breach notification regulations to health and fitness apps. The commission cited the policy’s minimal benefit and its supersession by rulemaking as reasons for the withdrawal, aligning with a deregulatory agenda, following insights from cyberscoop. ...
Lautato nominated for 2026 Ballon d'Or
A special day for the football world, with one of the most prestigious and eagerly anticipated events on the annual calendar drawing closer: the Ballon d'Or is back, one of the most important individu...
Republicans try to defy history with convention in Dallas
President Donald Trump and party leaders believe that by talking about all the good things that have happened over the last two years, they can boost GOP energy nationwide.
Talarico unveils GOP support, including former Dallas elected leaders
A group of Republicans supporting James Talarico includes former Dallas Mayor Steve Bartlett, former U.S. Rep. Alan Steelman and former Tarrant County Judge Glen Whitley.
5 things Greg Abbott must do at GOP convention
Gov. Greg Abbott addresses the GOP midterm convention Thursday. Here are five things he must do.
Indigenous fisherwoman finds ‘lost’ spinach pipefish, not seen by science in 40 years
Founder’s Briefs: An occasional series where Mongabay founder Rhett Ayers Butler shares analysis, perspectives and story summaries. On the final day of a two-week expedition, where researchers were searching for a “lost” species along Papua New Guinea’s Sepik River, Helen Asu arrived with two small, greenish-brown fish. She had caught them while fishing for prawns […]
How September 11 Changed American Politics Forever
As the memory of the attacks faded, it was inevitable that counterterrorism measures would draw more scrutiny — and voter priorities would shift.
Ectopic pregnancy deaths have nearly doubled. It’s worse in states with abortion bans
The number of women who died after an ectopic pregnancy has spiked in recent years, a ProPublica analysis found. The mounting deaths in Centers for Disease Control and Prevention data have drawn little scrutiny or response.
Slanted Cartography: The Politics of Mapping
There is much in the nature of a map. The very drawing of a line signifies an assertion, an acceptance, or even a repudiation of power. Borders are
Messi sets up Inter Miami equalizer after early Lewandowski strike
Lionel Messi set up Casemiro's equalizer as Inter Miami earned a 1-1 draw against Chicago Fire despite Robert Lewandowski's early strike. Poland striker Lewandowski fired the hosts into a 10th-minute lead at Soldier Field as he volleyed in Andrew Gutman's cross from the left.
Corinthians seek draw at Estudiantes in the Libertadores 🎥
Corinthians drew with Estudiantes in the first leg of the Libertadores quarterfinals.Wednesday’s match (9) in La Plata got off to a bad start for Timão.Castro opened the scoring just three minutes ...
Samsung works to draw iPhone users to its foldables even as Apple enters the market
Samsung is drawing more iPhone users to its foldables as Apple’s rumored entry threatens to reshape the market.
Arkansas River users give health leaders an earful over a spill of 4 millions gallons of raw sewage
Politics or NFL? Trump’s Dallas rally conflicts with season opener
President Donald Trump’s Republican midterm convention in Dallas has competition Wednesday night: the NFL season opener.
Flower Mound bakery taunts Trump with viral cookies
Hive Bakery is selling cookies to mark the GOP midterm convention, which runs two nights in Dallas.
New AI health tools need ‘L-plates’, says UK review
Proposals following national consultation on health tech regulation call for live monitoring as AI moves deeper into patient care
Appeals court declines to block ruling in favor of Missouri’s gerrymandered map
The decision marked another salvo in Missouri’s chaotic redistricting saga that has drawn national attention.
Commanders stadium expo in DC draws local businesses seeking construction work
Local contractors and suppliers gathered at an expo in D.C. Wednesday to explore opportunities on the Commanders stadium construction project.
Flutter Entertainment (FLUT) Faces A Valuation Test As Prediction Markets Draw NFL Attention
Flutter Entertainment (NYSE:FLUT) is stepping into the new NFL season with a fresh source of attention, as prediction markets attract industry focus and are discussed as potential rivals to traditional sports betting volumes. That renewed interest in prediction markets is arriving at a fragile moment for Flutter Entertainment’s share price. The stock trades at US$100.70 after a 7 day share price return of 3.81% and a 30 day share price return of 6.29%. However, it sits well below earlier...
Malone targets EFL return after non-League spell
Former Crawley Town left-back Scott Malone is hoping to use a training camp for free-agent players to attract League Two interest.
Veterans' mental health challenges
For many veterans, coming home does not mean leaving the impact of military service behind. As we approach the 25th anniversary of 9/11, it is important to recognize the mental health struggles many veterans face—often without treatment. Rawle Andrews jr., executive director of the American Psychiatric Association Foundation, discusses this with Good Day Austin.
What are you going to watch tonight, football or politics?
The NFL's first game of the season and the Republican Party's first-ever midterm convention vie for viewership.
Japan’s China-facing military push tests labour, budget and political limits
Amid ambitious transformation driven by risk it could be drawn into a Taiwan conflict, Tokyo tackles tough obstacles at home, analysts say.
Peripheral vascular disease: Answers to common questions
“Peripheral vascular disease is something we can often prevent or slow down by addressing the risk factors early,”
Las Vegas Arts District business improvement district proposal draws opposition
A proposal to create a “business improvement district,” or BID, in the Las Vegas Arts District is dividing property and business owners in the neighborhood.
Houston Chamber Choir goes globe-trotting with season opening show
Saturday's performance will also feature the debut of the 36-member Houston Youth Chorus.
As science comes under attack at UN talks, climate movement splits over how to respond
A rift over how IPCC messages are produced and turned into policy is creating tensions in the world's most influential coalition of climate NGOs
Ted Cruz swears off Supreme Court spot, despite Donald Trump's asking
Despite a clear affinity for the Supreme Court, Cruz said he turned President Trump down three times already.
First on CNN: Routine blood testing may hold hidden clues to colorectal cancer before age 45
When you have your blood drawn in a routine doctor’s visit, some of the markers in your blood that get tested could hold unexpected clues to how likely you are to develop colorectal cancer at a young age, new research suggests.
DIA to open first Georgia O’Keeffe exhibit devoted to famed artist’s architectural paintings
The Detroit Institute of Arts expects the show will draw 125,000 or more visitors at $20-$30 per ticket.
Jon Krawczynski: "I've covered this league for almost …
Jon Krawczynski: "I've covered this league for almost …
Paul Finebaum rips Geno Auriemma on state of college sports
Auriemma made headlines last week for his belief that college sports are "dying."
Parkinson demands more from Wrexham after draw
Manager Phil Parkinson acknowledges Wrexham have room for improvement after they were held to a 1-1 draw at home by Burnley.
Seagulls must learn from slow start
It's been a busy start to the 2026-27 campaign for Brighton and Fabian Hurzeler must now begin to prepare for a packed schedule of domestic and European football. Although the Seagulls will wait until October for their Conference League league phase to start, Hurzeler's side has endured a flurry of mixed results in their opening five games of the season. After a bruising 4-3 loss at Stamford Bridge to transfer-foes Chelsea, Brighton were lucky to escape with a 1-1 draw at home to Leeds.
2004-05 deja-vu - Can Moyes inspire another fine finish?
Deadline day may have left Everton fans feeling disillusioned, but the side is four games into the season and remains unbeaten, nine goals scored, including two in added time to secure a point. After what was a chaotic close to the transfer window, even by the Toffees' own standards, the performance against Manchester United ironically saw the summer signings playing a key role in the fight. Jack Grealish and Hayden Hackney came on from the bench to turn the game on its head, Tyrique George scored to equalise before the visitors went back in front, and it was Ainsley Maitland-Niles with a stunning strike to secure the draw in the final few seconds.
Curiosity Blog, Sols 4995-5001: 5,000 (Martian) Days on Mars
Written by William Farrand, Senior Research Scientist, Space Science Institute
Slanted Cartography: The Politics of Mapping
There is much in the nature of a map. The very drawing of a line signifies an assertion, an acceptance, or even a repudiation of power. Borders are
Revolut takes aim at business banking with FTSE 250 companies
Fintech’s business division has a target of 1mn customers globally by 2027
Duke Football Draws Praise From Illinois Ahead of Saturday Showdown
A certain area of the Duke Blue Devils' game against Tulane caught the eye of Illinois head coach Bret Bielema
Gen Z conservative influencers bring campus debates to Valley colleges, drawing online audiences
At a table on the campus of Mesa Community College, microphones are on, cameras are rolling and students are lining up to debate everything from politics and religion to culture and public policy.
California’s next governor will face destabilizing surge in uninsured
Should Xavier Becerra cruise to victory in the California governor's race in November, as polling suggests, he will face what may be the steepest decline in health insurance coverage in a...
Making Sense of Phoenix Suns' Biggest Storyline This Season
As roster shifts trade elite shooting for raw athleticism, Phoenix faces a high-stakes gamble on Miles Bridges to elevate their ceiling amidst looming threats of early-season regression.
Alex Michelsen’s Mysterious Girlfriend Draws Attention at US Open
Alex Michelsen and his girlfriend, Caroline, continue to keep a low profile during his successful run at the 2026 US Open. The post Alex Michelsen’s Mysterious Girlfriend Draws Attention at US Open appeared first on HEAVY.
US Open results 2026: Quarterfinal scores and semifinal bracket updates
US Open results and bracket updates for the 2026 men’s and women’s draws.
Supreme Court rejects Missouri's push to use new Republican-drawn U.S. House map in November
Missouri's new districts were used in the August primaries, but the Missouri Supreme Court ruled in September that the state must revert to districts adopted after the last census.
Dueling Court Rulings Leave Missouri’s Congressional Races in Chaos
After losing in two courts and winning in another, Missouri officials said they planned to forge ahead with using a congressional map that was redrawn to benefit Republicans.
Supreme Court rejects Missouri Republicans’ request to use new congressional map
Republicans rushed to the high court after the Missouri Supreme Court ruled the state could not use the redrawn map, which was designed to eliminate one Democratic-held seat, this year.
US House bill requires criminal background checks on Hollywood sets
A House bill would require criminal background checks for Hollywood set workers who supervise or regularly interact with minors.
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Solomon Islands domestic political squabbles could frustrate diplomatic engagement
No confidence motion withdrawn, but experts say volatility could undermine PM Wale’s pivot to Canberra, Washington
AI for better food safety: How tech helps uncover emerging outbreaks
Food-safety expert Willette M. Crawford discusses AI's role in preventing outbreaks and calling for recalls. She said regulatory challenges remain.
Detroit’s iconic Hotel Yorba has a new owner whose plans are still in flux
The new owner said he had originally planned on an affordable housing conversion but has gone "back to the drawing board" after a meeting with nearby residents.
Why Lewis Dunk Is STILL Brighton's Most Underrated Player
The veteran skipper remains the common denominator in Brighton’s success, transforming raw defensive partners into stars while proving he is the timeless heartbeat of the Seagulls’ backline.
Growth in every postcode: good politics, dubious economics
The UK government would be better off backing clusters and widening access to opportunity
When is the Carabao Cup draw for the fourth round?
Everything you need to know as the competition continues
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Preparations begin for Champions League opener in Como
The Champions League is drawing closer, with preparations now underway at Cottaweg. The Red Bulls began work on Tuesday ahead of their opening game away to Como 1907. Thursday’s 21:00 CEST kick-off ...
Has Tencent Music Entertainment Group (NYSE:TME) Fallen Below Fair Value?
Tencent Music Entertainment Group has seen its share price fall sharply over the past year, yet both an intrinsic value estimate based on a Discounted Cash Flow (DCF) approach and traditional earnings multiples currently point to the stock trading below those valuation checks. The disconnect between a weak recent share performance and signals of potential undervaluation is drawing attention to what the current price really implies about the business. Over the past 12 months the stock has...
Sherri Shepherd to join Broadway's 'Aladdin' as the Genie, and she's 'beyond thrilled'
Sherri Shepherd plans to join the Broadway musical “Aladdin” as the Genie. The Daytime Emmy Award-winning talk show host will take on the role from Oct. 16 to Jan. 3. Shepherd says she’s...
Daniel Farke provides fitness update ahead of Chelsea clash
After a quick turnaround following the weekend’s Premier League draw at Brighton & Hove Albion, attentions now turn to the trip to Chelsea for Wednesday’s EFL Cup Round Three tie for Daniel Farke�...
Richard Pan running for Congress on decade-old fight with RFK Jr.
The pediatrician and former state senator has long battled with the U.S. Health and Human Services secretary over California’s vaccine laws.
City Foundry developer suggests entertainment may be the best use for The Armory
Steve Smith wants to get a conversation started about whether The Armory should be converted into office space or kept as an entertainment venue. And the CEO of New + Found says that can’t just be theoretical: Part of developer TerraWatt’s plan to build a data center at the Famous-Barr warehouse next door comes with […]
Man Utd fans group call for derby-day ticket protest
The 1958 Manchester United fans' group is organising a protest ahead of Sunday's derby clash with Manchester City in protest at the club's handing of its ticket touting crackdown. United identified numerous instances of what they felt was ticket touting and in July placed restrictions on a large number of accounts and demanded details for why single devices were being used for multiple accounts, amid a threat of them being withdrawn. The message also warned the fan their season ticket could be deactivated for a Premier League game if they didn't buy a ticket.
Trump's beef import plan draws criticism from Alabama organizations, politicians
The president's move, which he said aimed to reduce prices, drew rare rebukes from state organizations generally supportive of him.
Street Fighter 6 gets a new gameplay trailer for Arjun, a new Indian brawler with a love for Bollywood
Capcom has released a gameplay trailer for Arjun, a brand-new character coming to the fighting game on the 13th October as part of the season 4 character pass.
Seminole Roundup: Soccer Draws While Volleyball Hosts SEC Foe
Wrianna Hudson nets a late goal as soccer battles Rice, while volleyball preps for an Auburn clash and golf sensations Shawn Coultoff and Sophia Fullbrook ignite strong starts.
UK-US trade could suffer as a result of sanctions for illegal Israeli settlements, American ambassador warns
UK foreign secretary to reassert support for Palestinian rights and a two-state solution in move drawing criticism from US and Israel
The GOP was confident about keeping its Senate majority. Now the fight for control is wide open
Control of the U.S. Senate is up for grabs with less than two months until Election Day. Republicans appeared to have a firm grip on the majority at the start of the 2026 election cycle. But Democrats...
Small Farms Get Hands-on Focus at Farm Science Review
LONDON, Ohio — At a farm show also known for massive machinery and sprawling field demonstrations, some of the most useful lessons for small-scale farmers...
X-Men Reboot’s Wild 4-Movie Comparison Includes Batman V Superman
A leaked script review for Marvel Studios’ X-Men reboot draws comparisons to four wildly different films. The surprising mashup description hints at the tone and style audiences can expect from the MC...
Hansi Flick sent strong Jose Mourinho message by Barcelona
Don’t get drawn into the circus.
Trump calls for a Bombardier plane ban, drawing pushback from a GOP senator
The president ripped the Canadian aerospace company Monday amid a trade war with the country, but Sen. Jerry Moran, R-Kan., came to Bombardier’s defense.
Field of Dreams draws visitors and boosts Dyersville businesses
The Field of Dreams in Dyersville continues to attract tourists and drive business growth, with events like a music festival and a Major League Baseball game bringing more activity to the area.
Santikos celebrates 115 years of the movies in San Antonio
Now a national name, the chain is expanding even more.
Richmond County Fair draws its biggest crowd ever for 3 days of food, rides and tradition
Since 1980, Historic Richmond Town has proudly hosted the Richmond County Fair on every Labor Day weekend.
What Italian media thinks of the latest Kolo Muani performance
Randal Kolo Muani was again disappointing as he led the line for Juventus in their match against AC Milan, a game that the Old Lady failed to win.The match ended in a 1-1 draw, but the men in black an...
TV presenter Sarah Khalifa sentenced to death in Egypt on drug charges
Sarah Khalifa, an Egyptian TV presenter and lifestyle influencer, has been sentenced to death as part of a sprawling drug case.
Calmatters: Californias Healthcare Affordability Office Claims Power To Punish Overspending Hospitals
CalMatters
The science behind what makes McDonald's Diet Coke superior
Why McDonald's Diet Coke tastes better than anywhere else, from chilled syrup to filtration and those iconic wide straws.
"Be in the TV Business": ESPN’s Paul Finebaum Changes Stance and Publicly Sides With $91M Head Coach
Paul Finebaum watched Lane Kiffin shift from college football’s problem to its new draw after one night in Baton Rouge. LSU head coach had been the villain in the eligibility fight before the 2026 season began, but now that same story is being sold as must-watch TV now.
Arizona Land Play Bets on Data Centers and Entertainment to Draw Capital West
Arizona Land Consulting plans a $6 billion to $10 billion Tonopah development mixing data centers, film studios, and an amusement park west of Phoenix.
Cravings ‘like heroin withdrawal’: what happens when weight-loss drugs don’t work?
GLP-1 medications have been a gamechanger in the fight against obesity. But for a minority of patients, their impact is negligible. Why?
Key moments in the Lindsay Clancy case: the 911 call, mental health care, mistrial
The judge has declared a mistrial in the Lindsay Clancy murder trial. After seven days of deliberating, the jurors failed to reach a verdict on whether she was criminally responsible for killing her three young children at her Massachusetts home. Judge William Sullivan declared the mistrial Friday. That came after jurors sent a note saying that they were “unable to come to a unanimous decision and will not be able to." The emotionally charged case has sharply divided many Americans and generated intense interest for over a month. It’s drawn attention to issues around maternal mental health after childbirth.
National award recognizes Laredo Public Health workforce efforts
Two Laredo Public Health leaders received national recognition for their work developing the public health workforce and connecting students with career opportunities.
Benton Neighbor Days parade draws crowds despite early Septe...
Benton Neighbor Days parade drew crowds as floats, bands, vehicles and horses rolled through early September heat.
3 Trade Targets Atlanta Hawks Should Avoid at All Costs
The Atlanta Hawks could make a major trade, but Domantas Sabonis, Kevin Durant and Anthony Davis would each bring significant drawbacks.