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Watch: Emotion and politics merge in Tehran at funeral of former supreme leader
The BBC's chief international correspondent Lyse Doucet is in Tehran, where funeral events are taking place in honour of Iran's former leader, Ayatollah Ali Khamenei.
Dodgers notes: Shohei Ohtani, Freddie Freeman, Yoshinobu Yamamoto
The Dodgers are riding high during their final homestand of the first half, taking a commanding 3-0 series lead over the San Diego Padres after shutting them out 3-0 on Saturday. The latter game’s success was done without Shohei Ohtani in the lineup, as the two-way superstar was absent after striking out nine hitters in […]
$28.5M modernization project planned at San Juan High School
Demolition and construction are taking place this summer at San Juan High School as part of a science wing and campus-wide modernization project, San Juan Unified School District officials say...
MBB Summer Preview: Minnesota Golden Gophers
Howdy, y’all! We are back again with another summer basketball preview, and today we’re taking a look at the Minnesota Golden Gophers. Minnesota finished last season at 15-18 with an 8-12 conference record, good for 11th in the Big Ten in head coach Niko Medved’s first year. They’ll be going into the season without two […]
Sky Sports: Manchester United considering two midfield options
Manchester United Transfer Plans: Tchouameni, Alex Scott and Summerville Lead Summer ShortlistManchester United’s summer is taking shape, and the message is straightforward. Midfield comes first. Ac...
Change is afoot at Xbox's Arkane Studios and MachineGames — with Machine's co-founder taking over Arkane's operations
MachineGames Studio Director and co-founder Jerk Gustafsson is seemingly taking over leadership of Arkane from the latter's president, Leonard Bendel, who has resigned.
Health officials offer tick safety tips as summer outdoor season ramps up
Mesa County Public Health is reminding residents that while tick-borne illnesses are rare in the area, taking precautions during outdoor activities can help reduce risk this summer.
Mariners OF Julio Rodríguez goes on 7-day concussion injured list after taking throw to back of helmet
Long Reads for the Long Weekend
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) Happy Fourth of July weekend! As has been a tradition of mine going back to the beginning of the EntStrategyGuy website, I’m sharing my favorite long reads of the last year, like I did in 2019, 2020, 2021, 2024, and 2025. Let’s dive right in! Subscribe “Different Prices for the Same Ride: How Uber and Lyft Use AI to Get More Money Out of You“ by Derek Kravitz in Consumer Reports I don’t think surveillance pricing, like the kind described in this brilliant Consumer Reports article, is long for the world—it’s toxically unpopular—but we’ll see if either party takes on this issue. If I ran a political party focused on affordability, I would focus on a few pro-consumer and pro-market policies: Banning non-compete agreements. Ending surveillance pricing Eliminating junk fees (read more here...) Ensuring “right to repair” for consumer (and military!) products Capping excessive app store fees Stopping digital/algorithmic price-fixing tools. Preventing automatic subscription price increases. And more. If you want to fight inflation, there are a lot of great ways to do it quickly. Speaking of higher prices... “Secret Documents Show Pepsi and Walmart Colluded to Raise Food Prices Across the Economy“ by Matt Stoller in BIG Again, I think a political party should focus on lowering prices for consumers. And deals like this—Walmart making a deal/forcing Pepsi to offer the lowest prices at its stores and nowhere else—hypothetically lower prices at Walmart...but raise them everywhere else. “15 DUIs, still driving: California’s failure to take repeat drunk drivers off the road“ by Robert Lewis and Lauren Hepler in CalMatters CalMatters does terrific reporting in California, something the Golden State desperately needs more of, and this article is a great example of that. “PugLips: The next insanely popular thing you’ve never heard of…” by Simon Carless in Game Discover Co I thought that this parody article (and yes, it’s a parody, but I was definitely unsure at first) was hilarious and totally nailed how much tech/business journalism feels these days. Actually, three of my favorite articles this year were on hype in the video game industry, including Georg Zoller’s “The Video Game Industries Very Dark Night”—which I linked to recently and wrote a follow-up here—and Owen Mahoney’s “Derek Zoolander, Videogame Exec”. In particular, I like Mahoney’s focus on user experience as a guide to what trends will actually grab hold of customers. “The Matrix Lies“ by Evan Shapiro in Media War & Peace Evan Shapiro’s first person account of his experience with AI was hilarious. I think LLMs capabilities have significantly grown from last summer, and yet...my editor/researcher just had an abysmal experience using an LLM to do a quite basic task (which our LLM normally does each week) and the LLM made a mistake on every single data entry...along with seven different mistakes affecting twelve of the twenty or so entries, including mistakes that are explicitly spelled out in the prompt. That’s a brutal failure rate. Again, if you use AI/LLM for data collection, you need to take a lot of extra steps to verify and check the data. “Ghosts in the Balcony: A Cross-Country Trip to 58 Theaters Fighting to Survive“ by Matthew Frank in The Ankler I thought Matthew Frank’s pitch to head across America to visit theaters sounded insane aggressive at the time—at least it felt that way to someone a decade older than him; man, to be in your twenties again, am I right?—but I knew the result would be great. And it was, a terrific feature by a great young writer. Also, I loved Matthew’s recent article on who’s getting the precious few entry level jobs in Hollywood. (Hint: nepotism.) “Disney erased FiveThirtyEight“ and “Did Las Vegas get too greedy?” by Nate Silver in Silver Bulletin I love media history and analysis, and there’s no one better to get the history of FiveThirtyEight than from Nate Silver, who wrote about his personal experience in one of my favorite pieces from this year. I also loved Nate’s breakdown of what’s causing Vegas’ woes, but I’ll offer one criticism, summarized as “Might I suggest antitrust?” Many centrists/center-right/libertarian thinkers (Nate is self-described as the latter) often don’t consider consolidation or antitrust as factors in policy issues like housing, America’s military readiness, or, in this case, Las Vegas. Even if libertarians want to debunk antitrust/consolidation concerns, I’d love to read that debunking. In this case, Vegas is incredibly consolidated (though it also has been for a long time) and I’d have loved to read Nate at least contending with this factor, since he addresses almost every other potential factor for Vegas’ decline. “Why Microsoft’s Carbon Removal Pullback Is Such a Big Deal“ by Robinson Meyer in Heatmap News I’m a big supporter of carbon removal efforts, but this nascent industry faces a lot of headwinds, including this big move most recently. I think it’s clear that solar panels and batteries should be able to get the world to its carbon footprint goals, but effective carbon renewal remains necessary to prevent the worst impacts of global warming. “AI is killing the cheap smartphone“ by David Oks LLMs and AI will impact the world in ways we’re not ready for, and already, third world countries are seeing the prices of cheap cellphones skyrocket due to the cost of chips skyrocketing. This article by David Oks is a terrific breakdown. “100 Days of Madness: Netflix, Paramount, Warner and the Future of Hollywood“ by Wade Major at Hollywood Heretic Wade Major dove deep into Hollywood/streaming’s financials in this must read piece. Not that I agree with everything in this article (read my take on Warner Bros./Paramount here) but the analysis is top notch. I think many people discount how quality thinking, regardless of the argument/conclusion, will make you a better thinker. “Erased by the UFC: Frank Shamrock, The MMA GOAT of the 20th Century“ by Nate Wilcox in The MMA Draw Newsletter Growing up playing the UFC fighting game on the Dreamcast, Frank Shamrock was my favorite MMA fighter, and this history/tribute to him was great. Other Fun Reads “The Hardest Part Of History To Tell Is How It Felt“ by Craig Fehrman at Defector “Unmasking the Sea Star Killer“ by Craig Welch at bioGraphic “What Could Save the Industry? Fin-Syn“ by Richard Rushfield in The Ankler Alex Rollins Berg in Underexposed on movie bumpers, pillow shots, Disney trash cinema, cult films, and Casablanca. David H. Montgomery in YouGov’s The Surveyor on punctuation marks, condiments, dinosaurs, and comic strips and kids media. “How Medium finally pivoted its way to profitability“ and “Why the best journalists on YouTube are all former Vox employees“ by Simon Owens in Simon Owens’s Media Newsletter “It’s Not Just You, Netflix Shows Have Gotten Slightly Shorter: Here’s What the Data Says“ by Kasey Moore at What’s on Netflix “Numlock Awards: How Diane Warren became the biggest loser in Oscar history“ by Nathaniel Rakich and “Numlock Awards: The Oscar Bait era is over. The Oscar Chum era is here.” by Walt Hickey & Michael Domanico at Numlock Awards
Madonna Returns With Long-Awaited ‘Confessions II’
The much-anticipated release is the culmination of a months-long rollout that included a surprise Coachella performance, a pop-up show in Times Square and "taking over the Gayborhood" on Grindr.
The business of America: Dallas taught the nation to think bigger
The city's embrace of entrepreneurship, growth and risk-taking powered the rise of Sun Belt capitalism.
Timeline Emerges For LeBron James' Free Agency Decision
Even at the age of 41, LeBron James still has basketball fans around the world anxious to find out where he's heading next. Despite taking a step back at times during the 2025-26 season, James flexed his muscles during the postseason. He powered the Los Angeles Lakers to the second round, averaging ...
Taking the world’s temperature: WHO chief spotlights global health emergencies
The hantavirus global outbreak is officially over, Ebola outbreaks are growing in Africa and responders are helping recovery efforts in quake-hit Venezuela, the World Health Organization (WHO) chief said on Thursday, announcing updates on global health emergencies.
This Week in Sports Trivia: July 2, 2026
How closely were you following the sports news this week? Find out and test your knowledge by taking The Athletic's weekly quiz.
Steelers roster spotlight: Can Rico Dowdle make history in Pittsburgh?
As the Pittsburgh Steelers move closer to the 2026 season, we’re taking a closer look at every player on the roster, with RB Rico Dowdle up next.
The big picture: Astrophotography buffs share tips and tricks
There's a whole range of equipment for taking photos of the universe. Aldrich Astronomy Society members share tips for every sky buff, and budget.
OpenAI proposes 5% stake to Trump administration to ease Washington pressure: report
Trump said in June that the U.S. taking an ownership stake in AI giants would be "a beautiful thing" and make American public "partners in this revolution."
Soaring revenue at Mar-a-Lago shows how Trump’s business interests and politics intersect
As President Donald Trump’s wealth has soared since retaking office, a new financial disclosure shows his two premier Florida resorts have also delivered record-breaking surges in revenue.
Soaring revenue at Mar-a-Lago shows how Trump’s business interests and politics intersect
As President Donald Trump’s wealth has soared since retaking office, a new financial disclosure shows his two premier Florida resorts have also delivered record-breaking surges in revenue.
Democratic Socialist who ousted 15-term incumbent speaks to OutFront: ‘voters taking power into their own hands’
Vance and Rubio take different approaches as Iran tests their 2028 prospects
Vice President JD Vance and Secretary of State Marco Rubio appear to be staking out differing approaches to carrying out President Donald Trump’s national security agenda as the possible 2028 presidential rivals jostle for position in a divided Republican Party.
Illinois State undertaking major upgrades to science research and teaching capacity through new project
Illinois State is undertaking a major upgrade of its science research and teaching capacity through the construction of three new facilities.
Sports entertainment veteran homers with interactive gaming sports bar, baseball outing indoors
Serial entrepreneur Lance Windholz — who spiked a career in tech to build community around beach volleyball in Shawnee — is batting again; this time, taking a swing at sports entertainment and the resurgent popularity of baseball.
UNESCO convenes scientific community for global conference on science
UNESCO invites you to the Global Conference of the International Decade of Sciences for Sustainable Development taking place from 15 to 17 July 2026 at UNESCO Headquarters in Paris, with ministers
What older adults need to know before taking a GLP-1 medication to lose weight
Starting Wednesday, millions of Medicare-qualifying adults will have access to popular medications for weight loss at deep discounts through a temporary federal program called the Medicare GLP-1 Bridge.
Communism isn't taking over the US, despite what GOP says
The idea that some overhyped radical left is about to take over the nation is laughably false.
“Dutton Ranch” hires new boss for season 2 after moving on from creator
A "Justified" alum is taking over the "Yellowstone" spinoff series.
Supreme Court agrees to review ban on AR-style semi-automatic rifles in major Second Amendment case
The Supreme Court announced Tuesday that it will decide whether cities and states may ban people from owning AR-15 rifles and similar semiautomatic weapons, taking up a major Second Amendment dispute that it had previously declined to address.
College basketball returns to KeyBank Center this October with doubleheader
The first game of the day will see Daemen College take on St. John Fisher, followed by Saint Bonaventure taking on Penn State.
Aisha Chughtai taking mental health leave from Minneapolis City Council
Klick Health Acquires Oxford PharmaGenesis, Bringing Together Unsurpassed Scientific-to-Commercial Capabilities for Life Sciences Clients
Focused on taking life sciences companies into the future, Klick Health today announced its acquisition of Oxford PharmaGenesis, the market-leading HealthSci...
Global financial firms pivot to South Korea, cautious on China and India, survey shows
Global financial firms are pivoting expansion plans towards South Korea while taking a more measured approach to China and India, according to an industry survey.
Game 86: Twins at Astros
First Pitch (CT): 7:10 PMTV: Twins.TVRadio: TIBN/830 WCCO/102.9 The Wolf /Audacy AppKnow Yo’ Foe: Crawfish Boxes After taking a series from the Colorado Rockies, the Twins are heading to Houston to face the Astros. An up-and-down season has Astros in a similar spot as the Twins: just below .500 and fighting to cement themselves in […]
Peptides are the latest US health craze. But what exactly are they?
While peptides are taking the health and wellness category by storm for various use cases, what exactly are they? Leerink Partners senior research analyst Michael Cherny helps break down what a peptides are, how people are choosing them for personal health and recovery reasons, and who the biggest winners in consumer pharmaceuticals could be if their popularity continues to grow.
Minneapolis City Council member Aisha Chughtai taking mental health leave for a month
Minneapolis council member taking leave for mental health treatment, cites turmoil in city
Council Member Aisha Chughtai said the city’s various challenges in recent months have taken their toll on her.
Supreme Court to review the legality of mass voter purges in the weeks before an election
The Supreme Court will review the legality of mass voters purges in the final weeks before an election, as part of a larger case the justices are taking up examining the methods Arizona uses to keep non-citizens off the voter rolls.
DMC Sinai-Grace holds 2nd annual health fair with free screenings, food, entertainment
DMC Sinai-Grace Hospital is taking patient care beyond the hospital walls and into the heart of the Detroit community.
DMC Sinai-Grace holds 2nd annual health fair with free screenings, food, entertainment
DMC Sinai-Grace Hospital is taking patient care beyond the hospital walls and into the heart of the Detroit community.
Building Business: New hotel taking shape on Portland's Monument Square
Zachau Construction is transforming the former Fidelity Trust building into a 101-room luxury hotel, for Jim Brady’s Fathom Cos.
Projected World Cup round of 16 matchups, live bracket
With the round of 32 underway, the 2026 World Cup round of 16 bracket is taking shape with teams advancing through the knockout round.
A tale of two World Cup experiences: As Boston reaps economic benefits, Foxboro suffers
With the World Cup taking place in their backyard, Foxboro-area restaurateurs say they have been left in the dark and are not reaping the benefits from the economic boom seen in Boston.
People are taking allergy and heartburn pills for PMS. Could it work?
Can the mix really help with premenstrual woes? Theoretically, the link between histamine and hormones could explain why the trendy DIY treatment seems to help some women.
These Michigan businesses are finding a silver lining with tariffs
Resale and salvage retailers are taking advantage of a circular, domestic supply chain as shoppers shift to bargain-hunting and buying local.
Lyles to take charge of Ultimate Championship entertainment
Noah Lyles has been announced as an Ultimate Star for the World Athletics Ultimate Championship, taking place from September 11-13 in Budapest, Hungary.Lyles, the dominant US sprinter who has won consecutive 200m golds at the past four World Championships, is locked in to compete at the inaugural edition of the new global championship. Lyles has earned automatic qualification into both the 100m and 200m by virtue of his podium-topping performances in those disciplines at the Paris 2024 Olympic Games and the World Athletics Championships Tokyo 25, respectively.
My son suggested the scenic route and now, he talks more in the car
My 12-year-old son suggested taking the scenic route, and now, my family has better conversations in the car. We also appreciate where we live more.
Conor Sen: This demographic cliff is reshaping universities. Cities are next
An undergraduate enrollment shortfall at Syracuse University is the latest sign that long-forecast demographic pressures are taking their toll on large and well-known institutions, too. Syracuse laid blame on the
World Cup Round of 32: Knockout rounds begin with Canada taking on South Africa
Design and Early Implementation Outcomes of a Mobile Health-Enabled Social Support Intervention for Adults Living With HIV and Type 2 Diabetes in Uganda
Background: Adults living with HIV and type 2 diabetes experience complex treatment demands that affect medication-taking, clinic attendance, privacy, social support, and engagement with care. M...
USF marine labs race to rebuild after fire
The college is taking a major step in its recovery by fast-tracking the process of purchasing lab equipment.
Oklahoma City business taking donations to help Venezuela following multiple earthquakes
Venezuelan restaurant VeneBurgers is organizing donations to provide Venezuelans with necessary items.
Rangers Go for Series Win on Saturday Against Blue Jays
The Texas Rangers will go for a series win against the Toronto Blue Jays at Rogers Centre with Cal Quantrill taking the mound.
First Bend Block Party draws crowds to Central District
Live music, art, food and fun are taking over Bend’s Central District for the first Bend Block Party. Come down to Second Street near Open Space and check it out before 9 p.m. today!
DJ and presenter Trevor Nelson taking a break from work due to health issues
The Radio 2 presenter said he was now "concentrating on getting better".
‘Turf Tank’ robot elevates Oregon sports fields
The Oregon Youth Soccer Association is taking advantage of some new technology to keep its fields game day ready.
Serious statin side effects on muscles are extremely rare, new research confirms
Scientists created a new tool to help doctors predict a patient’s risk of severe muscle problems from taking a statin.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Ormond Beach businesses push drivers to slow down on Granada Boulevard
Downtown Ormond Beach businesses are taking matters into their own hands after drivers continue to ignore a reduced speed limit on Granada Boulevard — nearly a year after the change took effect.
Romeo Doubs' Exit Could Raise the Stakes for Jordan Love in Green Bay
Jordan Love and the Green Bay Packers are eyeing a bounce-back campaign in 2026. The Packers opened the 2025 season with a strong start, posting a 9-3-1 record through their first 13 games, before a flurry of injuries derailed Green Bay's Super Bowl hopes. Since taking over as Green Bay's starter under center, the Utah State product has shown flashes of a top-five signal-caller, though the team hasn't yet made it past the divisional round under his leadership.
Grand Theft Auto VI pre-orders open, but don’t expect a physical copy
The blockbuster launch is expected to dwarf the box office takings of the year’s biggest movies with one industry analyst predicting it could make $1bn within an hour
Top Weekly Entertainment Picks
With America’s 250th Anniversary approaching, there are many star-spangled activities taking place in South Jersey, including a fireworks spectacular in
TikTok and YouTube are reinventing sports viewership. Broadcasters are taking note
Leagues, teams and media networks are increasingly meeting younger fans on social media as platforms like TikTok, Roblox and YouTube capture most of their time.
Residents sue City of Norman, other entities over Rock Creek Entertainment District
NORMAN, Okla. (KFOR) — The City of Norman and other entities are named in a lawsuit concerning Norman’s Rock Creek Entertainment District. The group taking them to court, Oklahomans for Respo…
SF Supervisor Jackie Fielder to return after mental health leave; reflects on recovery in video post
San Francisco Supervisor Jackie Fielder will return to City Hall next week after taking a three-month leave of absence, saying she stepped away from the job because her mental health demanded it. "This leave, and even my whole adult life, has been an entire journey on mental health," Fielder said. "And I know I'm not the only one who struggles with it."
Athens approves grant program for downtown business improvements
City leaders are taking applications from owners seeking storefront and signage upgrades
SF supervisor Fielder to return to City Hall after mental health leave
(BCN) — San Francisco Supervisor Jackie Fielder will resume her duties next week after taking a three-month leave of absence due to mental health. “I’m coming clear-eyed and groun…
Film Independent Spirit Awards to Present Robert Redford Environmental Vision Award
The new award in the late actor's honor "celebrates environmental fiction film and television projects taking an entertainment-first approach"
Andy Burnham to get briefings on taking over as prime minister
Sir Keir Starmer is offering "access talks" with the civil service to Labour leadership candidates.
Regions Bank Announces New Leaders in Key Markets to Drive Business Growth and Customer Experience
Lisa Phillips to lead Consumer Banking in Georgia and the Carolinas; Mia Hubbard to serve as Retail Service Delivery Manager for the entire Regions branch network. Regions Bank on Tuesday announced two key leadership appointments that will drive continued business growth in vibrant Southeastern markets while also supporting consistent service enhancements at branches throughout the company’s 15-state retail banking footprint. Longtime Regions banker Mia Hubbard (top left) will serve as Retail Service Delivery Manager, and Lisa Phillips (lower, right) will succeed Hubbard as Consumer Banking Executive for Regions in Georgia and the Carolinas. Lisa Phillips will serve as Consumer Banking Executive for Georgia and the Carolinas, overseeing branch performance and growth in vital and fast-growing markets such as Atlanta, Charlotte, and additional cities across the three states. Phillips succeeds Mia Hubbard , who is taking on the role of leading Service Delivery across Regions’ entire
Taking Wing: Jake Bloss
Today’s subject is in kind of an unusual spot as regards his prospect status. Bloss actually debuted two years ago, and as he turns 25 today (Happy Birthday, Jake) he’s on the fringes of what’s typically considered prospect eligibility. He’s also coming back from Tommy John surgery, which has eaten up the last 14 months […]
New York's primary will test NYC mayor's political power
New York Mayor Zohran Mamdani faces the biggest test of his political power since taking office with Tuesday's congressional primaries. Voters will decide if they back candidates he endorsed.
Sail 250 puts spotlight on Baltimore's local businesses and community organizations
As Baltimore prepares to welcome ships from around the world for Sail 250, local veterans are taking part in the historic celebration.
“Voicemails for Isabelle ”writer-director Leah McKendrick reveals the true story that inspired the romcom
A stand-up comedy set, a long-distance separation from her sister, and morbid thoughts of death all poured into the film currently taking off on Netflix.
Siouxland Sports Academy’s new multi-sport facility taking shape in Sioux City
Walls are starting to come up at The Siouxland Sports Academy’s new site as construction continues.
McKenzie announces entertainment lineup for Sweet Tea Festival, August 20–23
The City of McKenzie is excited to announce the return of the Sweet Tea Festival, taking place August 20–23 in McKenzie, Tennessee.
Report: Dusty May leaving Michigan for NBA head coaching job
BREAKING: According to ESPN’s Adam Schefter, Michigan Basketball’s Dusty May is taking the head coach job with the Dallas Mavericks:
Asheville film event to spotlight mental health, raise funds for counseling services
Filmmakers from across the Carolinas will be taking stage in Asheville as a regional film event aims to spark conversation about mental health.
Work Visa Issues Leave Door County Businesses Short Staffed for Summer
Decline in international summer workers under Trump administration taking a toll.
Kansas City small businesses say World Cup is hurting sales. There's no bump like the city promised
Kansas City has welcomed thousands of visitors as the metro enters its second week of the World Cup. But as international crowds come in, many local shop owners feel they're taking a backseat. Some small businesses say the economic boost is not evenly distributed.
Dbrand Is Now Taking Orders for Its Steam Machine Companion Cube Case
Dbrand is now officially selling its Portal-themed Companion Cube case for Valve's yet unreleased Steam Machine.
New dads with paid paternity leave have better mental health than those who lack it, study finds
Around 1 in 10 fathers experience postpartum depression. Taking paid time off may help symptoms and strengthen family bonds.
Sunday night Appy League highlights and scores
TRI-CITIES, Tenn. (WJHL) – With the home teams sweeping the Friday night games, and the visitors taking every Saturday game, the Appalachian League saw several Father’s Day rubber matches on the diamond. Burlington Sock Puppets 7 vs. Johnson City Doughboys 8Danville Otterbots 11 vs. Greeneville Flyboys 2Kingsport Axmen 4 vs. Bluefield Ridge Runners 1Elizabethton River […]
Why the Vikings should pursue Brendan Sorsby in supplemental draft
Here's the case for the Minnesota Vikings taking Brendan Sorsby in the supplemental draft.
Mamdani looks to flex political muscle in key New York House primaries
New York City Mayor Zohran Mamdani (D) is looking to use his political power to reshape New York’s congressional delegation less than six months after taking office. The popular mayor has mad…
Yankees' Paul Goldschmidt: Taking seat Sunday
Yankees' Paul Goldschmidt: Taking seat Sunday
Keir Starmer Reflects on ‘Political Challenges’ as Pressure to Resign Mounts
An ally of Keir Starmer’s told the BBC on Sunday that Mr. Starmer was “taking the time to think through what the political realities are today compared to last week.”
Google's Gemini Partially Figures Out A Lengthy Linux Boot Time On Modern ASUS Laptop
Google Antigravity with the Gemini 3.5 Flash model helped a Linux user sort out a situation where his laptop was taking around 36 seconds to boot the kernel, which shouldn't be the case for the high-end laptop with AMD Ryzen 9 processor and 32GB of RAM
Fernando Mendoza getting more comfortable taking snaps under center
"It's a great offense. I really believe in coach Kubak's offense," Mendoza said.
Autopsy Of A Freshly Cooked 10Gbit SFP+ Network Adapter
With the advent of affordable 2.5 Gbit, 5 Gbit, and 10 Gbit consumer networking gear, more and more people are taking advantage of these higher networking speeds, with [This Does Not Compute] havin…
3 team NBA blockbuster trade involving Giannis Antetokounmpo gaining momentum
The Giannis Antetokounmpo trade rumors are heating up once again, and the latest reports suggest the race for the two-time MVP may be taking another dramatic turn. For weeks, speculation surrounding Antetokounmpo’s future has dominated NBA headlines off the court.…
A day in the life of GORUCK cofounder Emily McCarthy
Emily McCarthy, who founded GORUCK with her husband Jason McCarthy, spends her days biking with her kids to their school and taking rucking meetings.
Madison’s new Forge Sports Center gives growing futsal community a home
Friday’s event brought together soccer fans watching the World Cup and players taking part in futsal, a fast-paced indoor version of soccer played on a hard court.
Dodgers on Deck: Saturday, June 20 vs. Orioles
The Dodgers turn to their ace on Saturday night against the Baltimore Orioles, with Yoshinobu Yamamoto coming off two gems in a row. Yamamoto retired his final 22 batters faced to beat the Angels on June 6 at Dodger Stadium, then retired his first 23 in a row against the White Sox in Chicago, taking […]
Cal lands commitment from 4-star WR Zion White
From the Golden State to the Islands to the Sunshine State, back to the Islands and now back to the Golden State. It is a full circle moment for Mililani (Hawaii) receiver Zion White. White announced his commitment to Cal after taking an official visit to Berkeley. “Honestly, I had been thinking about it and […]
Taking supplements every day? You might be doing more harm than good
While many of us take supplements regularly, there are some risks people may not be aware of.
Sumter Men’s Health Fair aims to connect men with physical, mental, and social wellness resources
A free community health fair in Sumter is taking a holistic approach to men’s wellness by bringing physical health, mental health, and social well-being resources together in one place.
Diamondbacks Place Starting Pitcher on IL with Elbow Injury
The Diamondback's rotation is taking another hit, as Ryne Nelson becomes the latest starter to land on the injured list.
Yankees' Jazz Chisholm Jr. says he's never worn protective cup after taking foul ball to groin
MARCO Mobile Medicine Brings Care Closer to Home
For many families across Appalachia, a doctor’s appointment can mean taking time off work, arranging transportation, traveling winding mountain roads and spending hours on the road for a visit. It’s a challenge familiar to generations of West Virginians, particularly those living in rural communities where access to specialty care can be limited. Today, Marshall Health Network is helping change […]