SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " 54 " 34,112 found 🔀 AI-powered Shuffle
NFL Week 7 Sunday afternoon open thread
Join us at Buffalo Rumblings as we chat all things NFL Week 7 LIVE with like-minded folks in Bills Mafia
Oregon fires offensive coordinator Drew Mehringer after team scored just 10 points in loss to Illinois
Saturday's loss marked the third straight game in which Oregon scored under 20 points.
Broncos Place Linebacker, Running Back On Injured Reserve
The Denver Broncos have a fluid injury situation, with Tyler Badie and Jonah Elliss being placed on injured reserve.
Warren, Steelers stiff-arm Saints for 16-10 Paris win
Jaylen Warren had another big day and the Pittsburgh Steelers overcame some red-zone inefficiency to beat the New Orleans Saints.
Saints Lose Defensive Battle in Paris Against Steelers
A very winnable game that a better team would have won.
Orlando Science Center hosts Halloween party
Adults can enjoy an open bar, laser shows, and more at the Orlando Science Center's Halloween After Dark on October 31.
Warriors honor Bay Area sports reporter Michael Wagaman
After Michael Wagaman passed away in early August, Dallas Braden took time to tribute him during his call of the Athletics’ game on NBC Sports Bay Area and California. Wagaman had covered Bay Area sports teams since 1996, including for the Associated Press, and freelanced for NBC Sports Bay Area and California at the time…
Browns injury update: Is Denzel Ward playing against the Titans?
The Browns will enjoy the presence of their top cornerback in Week 7.
Lakers’ Injury Report Rules Out Two Players for Jazz Game
Is Walker Kessler available in his return to Utah?
Week 7 inactives for Ravens
Baltimore declares five players inactive versus Cincinnati
Browns Week 7 inactives: Who's in, who's out?
The Browns are the healthiest they have been in some time as they take on the Titans in Week 7.
Astros should stay away from these 2 free agent outfielders
Astros shouldn't be interested in these two outfielders.
Liverpool 2, Brighton 0 – Match Recap: That Was Actually Fun
A look back at the key moments in Liverpool's great victory over Brighton in Premier League action.
Obama and Trump wage one last battle for even more urgent stakes
Two decades ago, Barack Obama stormed battleground states rebuking a Republican president over a deeply unpopular war and an economy that was crushing working Americans.
Chivu: “The boys gave everything right to the end”
Cristian Chivu wasn't the only one who couldn't bear to watch Zielinski's decisive penalty. The Inter coach bent over on the touchline, looking away as the midfielder stepped up to take it. When the b...
Game Time Thread: Juventus vs. Lecce
MATCH INFO When: Sunday, Oct. 25, 2026. Where: Stadio Via del Mare, Lecce, Italy. Official kickoff time: 6 p.m. local time in Italy and across Europe, 8 p.m. in the United Kingdom, 1 p.m. Eastern time, 12 p.m. Central time, 10 a.m. Pacific time. (Please note that the fall time change in Italy goes into effect on Sunday, […]
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Texas Tech Leads 'Bad' Week 8 for Big 12 Unbeatens
The Red Raiders’ playoff dreams hit a wall in Cincinnati as sloppy play and missed opportunities ended their unbeaten run. The Big 12 race is now more open than ever after surprising finishes elsewhere.
Robinson, Baker have tough talk about the offense
Robinson, Baker have tough talk about the offense
Mystery Ohio news site boosting Ramaswamy's Amy Acton ad tied to California GOP non-profit
As Ohio Republican gubernatorial candidate Vivek Ramaswamy came under fire for releasing an attack ad featuring his Democratic competitor Amy Acton's estranged mother, a mysterious news site was runni...
Their friend died of cervical cancer in 2020. Now, they advocate for women’s health in N.S.
Following the death of their close friend from cervical cancer in 2020, two women in Nova Scotia were left wondering how things might have been different had she been diagnosed earlier. Six years later, they have raised over $4 million to improve technology and infrastructure for women's health.
Seattle Mariners Rumors: Zach Neto Gaining Traction as Possible Target
The M's certainly have a need for what Neto can provide.
Wrexham’s Summer Striker Decision Faces Fresh Scrutiny After Blackburn Defeat
Wrexham’s decision to back their current centre-forwards has become a renewed talking point after Saturday’s 2–0 defeat at Blackburn Rovers exposed the gap between attacking activity and a meaningful goal threat.
GO Health asks families to be lead-aware
BATAVIA — Area health departments are encouraging families to get the facts and get their children and homes tested for National Lead Poisoning Prevention Week.
Micron Just Revealed a New Business Strategy. That Change Makes It a Screaming Buy.
Micron is changing more toward contracts, rather than letting the open market dictate pricing.
Aaron Rodgers throws 540th career touchdown, passing Peyton Manning on all-time list
Aaron Rodgers now sits third all-time in passing touchdowns.
Scientists Find Chronic Back Pain Activates a Brain Network Linked to Personal Identity
A new UC San Diego brain imaging study involving 114 adults suggests that chronic back pain flare-ups affect brain networks involved in self-reflection and personal memories. The findings may help exp...
Grading Iowa Football's Loss To Minnesota
This may have been Iowa's worst quarterback performance since the dreadful 2023 season.
Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks
The Boston Celtics beat the New York Knicks 107-103 on Friday night at TD Garden. Jayson Tatum scored 36 points and closed the game with a run that sealed the win. The stat line told the obvious story.But after the game, the moment Tatum wanted to talk about was not one of his own. It […] The post Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks appeared first on HEAVY.
Some Thoughts About Ron Duguay
Dear, departed Ron Duguay was not anything like his playboy image.
Roots music fest fun in downtown Yadkinville
Click here to view this article from yadkinripple.com.
Can social media bans protect young people’s mental health? Early research suggests that bans aren’t the answer
About 20 countries are looking to ban minors from social media. But bans have not always worked as planned. Here are some other ideas to make platforms safer for kids.
Stop Chasing Views: How 87% of Creators Are Using AI to Build Real Businesses Beyond Social Media
87% of creators say AI is growing their business. Here's how creators trade social media algorithms for owned commerce and real enterprises.
31 'Brooklyn Nine-Nine' Memes That Would Win a Halloween Heist and Become the Ultimate Detective/Genius
These memes are noice!
Nuthatches are rude: Ornithological observations from a recliner
I don’t know what age you’re supposed to start sitting in a recliner and looking out the living room window at the bird feeder, but I sure do like doing
Nick Nurse: “Jaylen Brown is obviously very good. He …
Nick Nurse: “Jaylen Brown is obviously very good. He …
Evan Mobley on Jarrett Allen: “The team loves it. …
Evan Mobley on Jarrett Allen: “The team loves it. …
Fernandes dropped: Man United name team to face Bournemouth
Manchester United have named their team to face Bournemouth in the Premier League, with captain Bruno Fernandes dropped from the side.Fernandes has been named among the substitutes at Old Trafford, in...
NFL Week 7 expert picks, score predictions: Packers at Lions
Green Bay Packers vs. Detroit Lions NFL Week 7 expert picks from the Pride of Detroit staff.
We moved to an apartment in another country without seeing it in person
We moved to an apartment in the Netherlands without seeing it in person. As Americans, we've encountered lots of surprises and cultural differences.
Colts vs. Vikings
Here is how the ColtsRoundtable staff sees the Week 7 matchup between the Indianapolis Colts and Minnesota Vikings unfolding.
Indiana football should be better. It also could be worse
On one hand, Indiana hasn’t played its best football in weeks. On the other, neither has anyone else, really.
Calvert liquor store gets license transfer; other business fined
New management will be taking over a liquor store in Dunkirk sometime in November.
Iowa Football Was Never Truly A CFP-Caliber Team. The Loss To Minnesota Proved It
The Hawkeyes had plenty of momentum after the Washington game, but there's just too much inconsistency right now. Everything fell apart against Minnesota.
Arkansas basketball displays true toughness against Gonzaga
The big story of the win over Gonzaga: These Hogs play defense
Mark Allen 'completely overwhelmed' after opening up about mental health
The snooker player has given fresh hope that he may return to competition
Browns QB Shedeur Sanders Pegged for Deadline Exit
The Browns are approaching a quarterback decision that could reshape their roster before the trade deadline. The post Browns QB Shedeur Sanders Pegged for Deadline Exit appeared first on HEAVY.
AI in policing risks deepening discrimination, research warns
AI tools learn from biased records and may deepen discrimination against minorities without oversight, researchers say.
Sources: Leeds hit by new hurdle in Nicolo Tresoldi race
Daniel Farke in a press conference with Leeds, with Paraag Marathe at Elland Road
Business Ins and Outs | Atlanta dessert shop, Provisions, Mexirican and donut shop opening
Business Ins and Outs | Atlanta dessert shop, Provisions, Mexirican and donut shop opening
The top 25 classic golf courses in Canada, ranked
We rank the best courses built in Canada before 1960.
Seamus Power, Austin Smotherman Share Lead In Windy Bermuda Showdown
Seamus Power and Austin Smotherman share the Bermuda Championship lead at 16 under, with fierce winds and PGA Tour playing privileges adding drama to Sunday's finale.
Utah Jazz Must Let Darryn Peterson Feel the Pressure
Shielding Utah’s prized rookie from high-stakes moments only stunts his growth. To secure their future, the Jazz must force Darryn Peterson to embrace the game-deciding pressure now.
Texas A&M Defense Folds Again As Alabama Exposes Aggies In Late Collapse
Texas A&M's defense surrendered 311 passing yards and two fourth-quarter touchdowns in a 31-20 loss to Alabama, raising more questions about Mike Elko's Aggies.
The Health Benefits of Blueberries—and the Best Ways to Eat Them
Are blueberries good for you? Experts share the health benefits of these popular berries. Plus, discover what to look for when buying blueberries, the best way to store them, and how to use blueberries in your food and cooking.
Building bridges that lift us above hate
When Mohammed Al Samawi was growing up in Yemen, the son of a pair of middle-class doctors, teachers taught him that Jews and Christians were enemies destined for hell. “We were trained as children to hate,” he told an audience of some 450 at an antisemitism conference in Denver last week. Like many of his […]
What happened to the cast of ‘I Dream of Jeannie’? See the stars more than 55 years later
‘I Dream of Jeannie’ paired Barbara Eden’s genie with Larry Hagman’s astronaut for five seasons of magic. See what became of the cast more than 55 years after the final episode.
This Week in Purple: Around The World (Series)
Colorado Rockies news and links for Sunday, October 25th, 2026
Real Madrid rocked by Thibaut Courtois INJURY BLOW just hours before El Clasico showdown with Barcelona
Real Madrid have suffered a major setback ahead of their crucial Clasico showdown against Barcelona after goalkeeper Thibaut Courtois was ruled out through illness. His late withdrawal forces the club to rely on deputy Andriy Lunin for the vital Liga fixture at Camp Nou.
Sunday Night Football: How to watch the Kansas City Chiefs vs. Seattle Seahawks game tonight
Sarkozy's son warns violent protests in France could worsen amid political unrest
Louis Sarkozy, son of former French President Nicolas Sarkozy, discusses violent unrest in France, the influence of far-left groups and the country’s immigration and economic challenges.
The top 25 modern golf courses in Canada, ranked
Our ranking of top modern Canadian courses returns, with Nos. 1 and 2 sitting side by side.
CBS News political experts weigh in on Texas Senate race halfway through early voting
The latest CBS News poll showed Talarico leading 51% to 49%, well within the margin for error.
Paris Pressure: Saints Must Block Out the Chaos and Finish Their Business Against the Steelers
How to Watch: Arizona Cardinals vs. Denver Broncos
Everything you need to know about the Arizona Cardinals game against the Denver Broncos.
Los Angeles Rams vs. Las Vegas Raiders: How to watch the NFL Week 7 game, channel, streaming info and more
Cincinnati Bengals vs. Baltimore Ravens: How to watch today, start time, where to stream and more
How to watch Lions vs. Packers: TV, streaming, radio, more
TV, online streaming, announcer, and kickoff time information for Detroit Lions vs. Green Bay Packers.
Colts Make Roster Moves Ahead of Sunday's Matchup
The Indianapolis Colts made roster moves ahead of Sunday's matchup against the Minnesota Vikings.
YouTube Gold: Highlights From Louisville’s Trip To Kansas
Kansas lost Wednesday, but the Jayhawks are not exactly pushovers
18 Once-Common Things That Quietly Vanished From Our Lives
"I texted one of those numbers on the TV to buy a ringtone back then. Good times. Then smartphones came around, and I've kept my phone on vibrate for over 13 years now."
Are the Bills playing today? NFL Week 7 schedule, next game, AFC East standings
The Buffalo Bills and star QB Josh Allen are off to a terrific start to the 2026 NFL season. Here's what's on deck for the team in Week 7.
UCLA’s perfect start has one glaring flaw it must fix soon
Bob Chesney has made UCLA the second-half darlings of college football, but the Bruins must address their slow starts if they hope to reach the playoff.
The Political Upstarts That May Decide Israel’s Election
The upcoming Israeli election may be decided by two small parties that didn’t even exist a few months ago.
Why partisan politics may be changing people's accents
With the midterms fast approaching, communicating just the right message has been top of mind on all sides of the political aisle
Swapping horses for ninja warriors: The Olympic sport undergoing massive change
Several Olympic sports have evolved over the years to keep up with an ever-changing landscape, but few have been as drastic as the Modern Pentathlon.
Meet the New Orleans Halloween fanatics sparing no expense to delight or fright, ‘just because’
Come October, these otherwise average homes transform. Spiderwebs shroud the shrubbery. Candles flicker in the windows. Ghosts and ghouls haunt the front porch. These aren’t the kind of households to give out “chump candy.”
Juventus is limiting one of their best players
Kerim Alajbegovic was expected to receive considerably more playing time following Kenan Yildiz’s injury, which is set to keep the attacker out of action until the end of 2026. However, things have ...
Scientists Simulated Solar Explosions in The Lab – And May Have Solved One of The Sun's Biggest Mysteries
A fiery paradox.
What happened when humans encountered Gigantopithecus?
Gigantopithecus was the largest primate that ever lived. What would have happened when human ancestors encountered it?
GMA News
DOOMSDAY IS COMING! 🎬 LOOK: Marvel Entertainment drops a new trailer for the upcoming "Avengers: Doomsday" movie, featuring Chris Evans as Captain America, Chris Hemsworth as Thor, and a look at...
Dana White Praises Merab Dvalishvili After UFC 333
UFC president Dana White praised bantamweight fighter Merab Dvalishvili following his fight against Petr Yan at UFC 333.In the trilogy championship bout between Yan and Dvalishvili, the two long-time rivals went the full 25 minutes and put on an absolute show as they went back and forth for five rounds before Yan ultimately edged out […] The post Dana White Praises Merab Dvalishvili After UFC 333 appeared first on HEAVY.
Liverpool committing to Barcelona model, massive change for club
Liverpool are committing to the Barcelona model. It's a massive change for the club - but will it pay off?Liverpool have a transfer strategy under Jurgen Klopp and it was a wildly successful one. They...
😂 Mystery note? BVB match-winner explains bizarre moment
Did you catch the curious scene after the final whistle in the big clash between Borussia Dortmund and Eintracht Frankfurt? Match-winner Maxi Beier suddenly found himself holding a piece of paper shor...
Steven Gerrard praises Bayern Munich star Harry Kane
The greats of the English game recognize the greatness of the FC Bayern striker
Unwanted endorsement: Political ad causes uproar at Jerusalem's Lev Academic Center
Those who know the highly regarded college, which since 1969 has produced religious graduates with degrees in a variety of engineering fields and nursing, were likely surprised. Thousands of drivers a...
Building a rural business empire on the back of coffee beans
Lewie Graham runs a cafe, restaurant and coffee bean roasting business in Kirkcudbright.
Cowboys Standout in Second Half in Win Over Colorado
Oklahoma State's defense stifled Deion Sanders’ Buffaloes while the offense exploded for 37 unanswered points, turning a halftime deficit into a dominant Homecoming rout at Boone Pickens Stadium.
USC Legend Tells Lincoln Riley "It just Ain't Working Out" as He Calls for "Tough Decisions" at His Alma Mater
Lincoln Riley is running out of excuses, and USC is running out of patience. Just a week after showing promise against Penn State, the Trojans embarrassed themselves in a 24-7 loss to Wisconsin, exposing an offense that looked completely lost.
Where to watch Kansas vs. Duke basketball: Channel, live stream, time, TV schedule for men's exhibition game
It's a preseason matchup of blue bloods as Duke visits Kansas on Sunday. Here's when and where to tune in.
What business thinks of the politicians and parties
Business leaders are hard to impress this election. In the Herald's annual “Mood of the Boardroom” survey, they give poor or middling marks to almost the whole political class, including the two former business executives running the Government's economic policy, and several ratings are among the wo
These Milwaukee Brewers are two games from immortality in World Series
What gets fact-checked? How politics shapes the answer in four African countries
Many fact-checkers are moving away from declaring claims as true or false, and trying to help people judge information for themselves.