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FDA clears portable photon-counting CT scanner
The system is designed for point-of-care settings such as outpatient offices, sports medicine practices and urgent care clinics.
Nine Brody School of Medicine students match to ECU Health for residency training
Fourth-year medical students from the Brody School of Medicine learned where they will take on residency during Match Day.
Inside the DOCS Community Health Leadership Conference at the Miller School of Medicine
Medical students at the Miller School lead the DOCS Community Health Leadership Conference, showcasing student‑run projects.
MDMA Therapy in Australia Shows Results for PTSD Patients, but the Cost Is Limiting Access
The country’s experiment with psychedelic medicine has led to positive outcomes, psychiatrists say, but also highlights the limitations of the nascent field.
Insulin pills may soon replace daily injections
For over a century, scientists have chased the dream of insulin pills, but the digestive system kept destroying the drug before it could work—forcing millions of patients to rely on daily injections. Now, researchers at Kumamoto University have developed a clever workaround using a tiny peptide that helps insulin slip through the intestinal wall.
Expanded NICU offers families privacy, innovation
The NICU at Temple Health's new Women and Families Hospital offers twice the space and many more services than its predecessor.
Bridging science and music - College of Arts and Sciences
Graduate student Briana Nave studies music's use and interactions with modern scientific medicine in the early 20th century.
Inaugural Health Care by Food research award honors excellence in food is medicine science
DALLAS, March 23, 2026 — At a time when American dietary patterns are facing renewed attention, the American Heart Association has announced its inaugural Health Care by Food™ Most Impactful Food Is Medicine Research Award, honoring the year’s most...
Inaugural Health Care by Food research award honors excellence in food is medicine science
DALLAS, March 23, 2026 — At a time when American dietary patterns are facing renewed attention, the American Heart Association has announced its inaugural Health Care by Food™ Most Impactful Food Is Medicine Research Award, honoring the year’s most...
The AI push in health care is deepening medicine’s trust crisis
Health care’s adoption of AI should move at the speed of trust, not investment, writes Oni Blackstock.
Turning coal to medicines: Chinese scientists bring a 160-year-old dream to life
Study cracks a puzzle that has baffled scientists and will reshape modern medicine production as the world reels from a global oil shortage.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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RFK Jr. Touts Food as Medicine. He Often Overstates the Science, Experts Say.
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RFK Jr. makes food sound like a miracle drug. Researchers say he often overstates the science
In the Trump administration’s campaign to promote healthy eating, Robert F. Kennedy Jr. has not stopped at his slogan urging people to “eat real food” to prevent disease. In recent speeches and…
RFK Jr. Makes Food Sound Like a Miracle Drug. Researchers Say He Often Overstates the Science
In the Trump administration’s campaign to promote healthy eating, Robert F. Kennedy Jr. has not stopped at his slogan urging people to “eat real food” to prevent disease. In recent speeches and podcast appearances, the nation’s health secretary also has claimed that diet can “cure” schizophrenia and ...
RFK Jr. Makes Food Sound Like a Miracle Drug. Researchers Say He Often Overstates the Science
In the Trump administration’s campaign to promote healthy eating, Robert F. Kennedy Jr. has not stopped at his slogan urging people to “eat real food” to prevent disease. In recent speeches and podcast appearances, the nation’s health secretary also has claimed that diet can “cure” schizophrenia and ...
Women in Medicine and Science Research Day Highlights Achievements and Opportunities
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20th Annual Women in Medicine and Science Research Day
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Pursuing a passion for public health
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The scientist who warned that profit, not science, decides which drugs reach patients
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Women’s Health Research Advancing at UConn
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Alto Neuroscience Reports Full Year 2025 Financial Results and Recent Business Highlights
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How to recover after a workout
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Girls learn about medicine, meteorology and other STEM careers at CBS Colorado's Girls & Science 2nd Saturday event
Bill Cassidy faces another MAHA fight with his reelection on the line
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Girls learn about medicine, meteorology and other STEM careers at Girls & Science 2nd Saturday event
GSK and Amgen to add medicines to TrumpRx, Fox Business reports
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NYC Health + Hospitals Receives Six Sing for Hope Pianos Designed by Artists - NYC Health + Hospitals
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Connecticut Academy of Science and Engineering Elects Eight From YSM
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Around the MHS
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AHA podcast: Better Teams, Better Mental Health Care
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The Startup Trying a New Trick to Develop AI For Science Discovery
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This Harvard dropout took a company public before 30. Now he’s raising $205M to fix the business side of medicine
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Opinion: Colorado health care system should include food as medicine
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ETSU, Health Wagon team up for free medical services in SWVA
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Michigan Medicine resists significant cuts by Blue Cross Blue Shield of Michigan that would limit patient access
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Prime Medicine Reports Full Year 2025 Financial Results and Provides Business Updates
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The science of structures: FSU chemist synthesizes complex molecule with potential for medicine, pharmaceutical applications
A Florida State University chemist has developed a method to rapidly assemble significantly complex natural molecules with potential in biomedical
Iran’s Islamic Revolutionary Guard controls a sprawling business empire that dominates the economy
That empire includes core industrial sectors like oil and transportation as well as banking, telecommunications, agriculture, medicine, and real estate.
Conexeu Sciences Appoints Jean-Romain (JR) Falconnet as Head of Business Development & Licensing
Reno, Nevada--(Newsfile Corp. - March 2, 2026) - Conexeu Sciences Inc. ("Conexeu" or the "Company"), a biotechnology innovator redefining regenerative medicine through a next-generation extracellular matrix platform, is pleased to announce Jean-Romain (JR) Falconnet as Head of Business Development & Licensing.In his role at Conexeu, JR will lead business development, licensing strategy, and strategic partnerships—supporting the company's growth roadmap and expanding opportunities to bring...
Vanderbilt Health to Become Tennessee Titans’ Official Healthcare Provider
In addition to sports and event medicine services, the partnership brings two community leaders together for exciting new initiatives centered around the Monroe Carell Jr. Children’s Hospital at Vanderbilt and community youth sports.
Submission Period Now Open for the 2026 Eric and Wendy Schmidt Awards for Excellence in Science Communications; $640,000 To Be Awarded
Submissions are now being accepted for the 2026 Eric and Wendy Schmidt Awards for Excellence in Science Communications. The awards honor exceptional science communicators, science journalists, and research scientists who have developed creative, original work that addresses issues and advances in science, engineering, and medicine for the general public.
Defying all odds, doctor transforms adopted daughter's health using functional medicine
When a doctor was told there was no cure for his daughter's condition, he was motivated to transform not only her health, but the lives of thousands of others.
Sebastopol business Soft Medicine Sanctuary closes
Owners announced Saturday will be the business’ final day after the wellness collective said it had ousted its founding majority owner amid allegations of abuse and financial concerns.
Harnessing data science for health discovery and innovation in Africa (DS-I Africa)
Communications Medicine - Xiong et al. discuss the Data Science for Health Discovery and Innovation in Africa, a US-Africa partnership aiming to transform health via innovative data science....
Harnessing data science for health discovery and innovation in Africa (DS-I Africa)
Communications Medicine - Xiong et al. discuss the Data Science for Health Discovery and Innovation in Africa, a US-Africa partnership aiming to transform health via innovative data science....
March 2026
March’s issue focused on healthcare, with our list of the state’s top hospitals based on analysis of reports from both public and private agencies. We also featured a Q&A with Dr. Hershey Bell, founding dean of Methodist University School of Medicine, which welcomes its first cohort in July. Another feature was on a Triad nonprofit’s […]
European health agency recommends approving Moderna’s combined flu, COVID vaccine
The European Medicines Agency (EMA) announced Friday it has recommended Moderna’s combined mRNA COVID-19 and flu vaccine be granted market authorization in the European Union, marking the fir…
SGMC Health Welcomes 4 Family Medicine Residents
SGMC Health is welcoming four Family Medicine resident physicians who will join the health system as postgraduate year‑one (PGY‑1) residents
1,200 Emory interprofessional students team up to confront Atlanta’s health challenges | Emory University
First-year students from Emory’s schools of medicine, nursing and public health formed 115 cross-disciplinary teams that worked together to address health challenges facing Atlanta communities during IPE-ACTS Day 2026.
Scientists turn methane into medicine in stunning breakthrough
Scientists have unveiled a breakthrough way to turn natural gas—long burned as fuel—into valuable chemical building blocks for medicines and other high-demand products. By designing a clever iron-based catalyst powered by LED light, researchers managed to activate stubborn molecules like methane and transform them into complex compounds, even creating the hormone therapy drug dimestrol directly from methane for the first time.
Rams SVP of Sports Medicine and Performance Reggie Scott named Outstanding NFL Athletic Trainer of the Year by NFL Physicians Society
Reggie Scott, the Rams' Senior Vice President of Sports Medicine and Performance, was honored with the NFL Physicians Society's Fain-Cain Memorial Award for Outstanding Athletic NFL Trainer of the Year at organization's annual scientific meeting during th
Sebastopol business owner ousted after allegations of sexual assault, financial coercion surface
Jonathan Pinkston, an owner of Soft Medicine Sanctuary in Sebastopol, has been ousted from the business after allegations of assault and financial coercion.
Stony Brook Women’s Health Research Conference on March 25
The Renaissance School of Medicine will host the inaugural Stony Brook Women's Health Research Conference on Wednesday, March 25.
Medicine on the slopes: Caring for winter athletes
UNR Med’s Sports Medicine Fellowship trains physicians to treat winter sport injuries on the slopes and in clinics across Northern Nevada.
Casey Means, Critic of Mainstream Medicine, May Become Nation’s Top Doctor
Dr. Means, a wellness influencer and President Trump’s nominee for surgeon general, will appear before a Senate committee Wednesday.
UK HealthCare launches Food as Health initiative across Kentucky
UK HealthCare is expanding its Food as Health Alliance, a new initiative embedded within UK HealthCare that delivers “food is medicine” services to improve health outcomes for vulnerable populations across Kentucky.
New ranking highlights NIH’s impact on breakthrough science at Duke
Duke University School of Medicine received more than $514 million in research funding from the National Institutes of Health (NIH) in 2025, ranking 9th nationally among medical schools, according to new data from the Blue Ridge Institute for Medical Research
AbbVie to invest $380 million to expand US manufacturing in Illinois
AbbVie on Monday said it would invest $380 million to build two new active pharmaceutical ingredient manufacturing facilities at its Illinois campus, expanding its domestic production capacity for its neuroscience and obesity medicines.
Girding against Keytruda cliff, Merck splits oncology into standalone business unit
The patent cliff for Keytruda is fast approaching in the U.S. Now, as Merck & Co. | The patent cliff for Keytruda is fast approaching in the U.S. Now, as Merck & Co. increasingly looks to life after its oncology megablockbuster, the company is honing its focus on new and upcoming medicines by splitting its core pharmaceutical business in two.