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Cavan Sullivan & Philadelphia Union face San Diego FC test
By Cal MeachemCavan Sullivan and the Philadelphia Union take their scorching form cross-country to face San Diego FC for Matchday 26's Sunday Night Soccer presented by Continental Tire clash.How to w...
Olivia and Tom Walton pledge $100M for national campaign to cut maternal deaths
Philanthropists Olivia and Tom Walton announced Thursday they’re giving $100 million toward a national effort to cut maternal deaths in half.
Soprano Brenda Rae flies in to replace Lauren Snouffer for Opera Philadelphia’s opening night
Brenda Rae has stepped in as the lead soprano in Mozart’s “Mitridate” at Opera Philadelphia's opening night.
Soprano Brenda Rae flies in to replace Lauren Snouffer for Opera Philadelphia's opening night
Brenda Rae has stepped in as the lead soprano in Mozart’s “Mitridate” at Opera Philadelphia's opening night | NewsRadio 1080 KRLD
Mission accomplished
After a 14-month construction mission, the “Apollo” landed at the Kelly Falls apartment complex this week with the completion of the Mark Stebbins Community Center, the culmination of a vision by the late Mark Stebbins, a long-time business leader and philanthropist.
Healthy Moms, Healthy Babies America pledges $100M to cut US maternal mortality rate in half
Healthy Moms, Healthy Babies America announced a $100 million pledge Thursday to make giving birth in the United States safer.
Skill games could be seized from Pa. businesses in October, state police warn
In June, the state Supreme Court ruled the gambling machines are unconstitutional. Lawmakers must regulate them by Oct. 13.
Sources: Olympiacos Snatch Imanol Alguacil from Under Bournemouth’s Noses
Olympiacos secured Imanol Alguacil's signature after outmanoeuvring Premier League suitors, including Bournemouth, Liverpool and Nottingham Forest, bringing a trophy-winning philosophy to Piraeus following his historic stint with Real Sociedad.
Meet a Health Hero Finalist: Rachel Rutter
The Phoenixville immigration attorney founded Project Libertad to help advocate for and provide all-encompassing support to youth asylum seekers.
Sage on Doucoure, team spirit and Ipswich
Crystal Palace boss Pierre Sage has been speaking to the media before Saturday's Premier League game against Ipswich Town at Selhurst Park (kick-off 15:00 BST). Midfielder Cheick Doucoure is in contention to be part of this weekend's squad. Sage also confirmed that Jean-Philippe Mateta remains unavailable to face Ipswich.
‘Not Here for Entertainment’ – 76ers Star Jaylen Brown Reveals a Different Kind of Legacy He Wants to Be Remembered By Once It’s All Over
Jaylen Brown‘s immediate goal right now is to become a two-time champion, and it has become more possible for him now that he is with the Philadelphia 76ers. Sixers fans rejoiced last July after they acquired one of the best players of the 2025-26 season without giving up that much. They received Brown in exchange [...]
Who made the cut for our 2026 Phillies All-Prospect team?
Teenage breakouts, power surges and strikeout arms lead this year’s selections.
Clement explains star man’s absence after Norwich City beat Birmingham
Philippe Clement says Norwich City left Mo Touré out of their squad for the 2-1 win over Birmingham to avoid risking another injury amid the Championship’s demanding schedule.Touré had been in imp...
NFL Week 1 television maps: Commanders vs. Eagles
If you're located in the red area of the map, you'll see the Washington Commanders and Philadelphia Eagles Week 1 matchup on your local FOX station.
Four Japanese scientists win prestigious U.S. Lasker Awards
One received the prize for his work on a sleep-regulating brain chemical, and a trio, for discovering an antibody therapy for hemophilia A patients.
Phillies' Kyle Schwarber Speaks Out After Crazy Win Over Astros
Philadelphia Phillies star Kyle Schwarber took some time to speak out after a wild win over the Houston Astros.
FC Cincinnati loses game, players, in disastrous loss
FC Cincinnati took a disastrous loss at Philadelphia Union
A.J. Brown leaves his Patriots debut with an ankle injury
A.J. Brown injured his right ankle in his New England Patriots debut Wednesday night against Seattle, and the standout receiver was questionable to return. Brown was hurt early in the third quarter on an incomplete pass from Drake Maye. The Patriots acquired Brown in an offseason trade with Philadelphia.
Wednesday practice report for Philadelphia
Philadelphia Eagles Week 1 practice report for Wednesday.
Chinese Distributor Hishow Adds ‘Josephine’, ‘Ah Girl’ & ‘Rec’ Franchise To We Love Cinema Release Slate
EXCLUSIVE: Beijing-based producer-distributor Hishow Entertainment is expanding its cinephile ‘We Love Cinema’ brand with a slate of new acquisitions including recent Sundance winner Josephine and Ah ...
76ers Reveal First Look at New Stadium
The 76ers and Flyers will have a new home soon. All the history is something many will remember.
Director of Philanthropy for Maui Health Foundation to speak at Rotary Club of Lahaina Sunset
The Rotary Club of Lahaina Sunset welcomes Leana Taylor, Director of Philanthropy for Maui Health Foundation on Tuesday, Sept. 15, 2026. The topic of her presentation will be “Food Is Medicine: Locally Grown, Physician Prescribed.”
'We could have scored more'
Norwich City boss Phillippe Clement speaks to BBC Radio Norfolk after the 2-1 win over Birmingham
'America's Nobel' prizes go to sleep and hemophilia researchers, and to Michael J. Fox for Parkinson's advocacy
The Lasker Foundation has announced the winners of its 2026 awards for basic medical research, clinical science and public service.
Before construction on Commanders stadium begins, roster of small business contractors needs to be filled
While the Commanders will be kicking off their first game of the season this weekend against the Philadelphia Eagles, the team behind the new stadium at the old RFK site is looking to fill out their rosters with subcontractors and small businesses.
Pedophile support chatroom addresses Jim Thornton ‘Wheel of Fortune’ firing
NEW YORK — The organizers of a pedophile support chatroom allegedly visited by former “Wheel of Fortune” announcer Jim Thornton has issued a statement in the wake of his firing.
16 Seattle-area author events happening this fall
From national book tours to conversations with local authors, take note of these upcoming bibliophile events in the Seattle area.
Preserving the Academy of Natural Sciences
Philadelphia's Academy of Natural Sciences is slatted to close at the end of the month. But can the the 200-year-old museum to be saved?
‘Birds Supporting Birds’ connects the Philadelphia Eagles with migrating seabirds
Football fans and avian enthusiasts can follow four great shearwaters named Phil, Franklin, Hoagie, and Liberty.
Vrancken has captured imagination of Hearts fans
There was a sense of inevitability about Hearts' late winner against Dundee on Sunday. Much of the credit for Hearts' recent form must go to Wouter Vrancken. The Belgian's style of play has captured the imagination of the Hearts support and, just as importantly, the players have fully embraced his football philosophy.
Diamondbacks release former Twins, Phillies .736 OPS outfielder
This comes as no surprise for the Diamondbacks.
76ers Sign Another Player To Exhibit 10 Contract
Philadelphia is doing everything to get there team ready for the season. Adding Dillion Jones could help with a lack of depth.
Eagles Receive Positive Playoff Prediction From ESPN
ESPN gave the Philadelphia Eagles a positive playoff prediction.
Walker, Smith, Varsho homers power Astros to 6-5 win over the Phillies
The Astros began the three-game series with a two-game lead on Texas atop the AL West.
Birthright launches Global Business Summit, connecting Diaspora donors, Israeli financial figures
Three-day gathering to take place in November, aimed at showing 'a different face of Israel' to group's funders — and maybe attracting new ones
Small Business Spotlight: Guitar shop aims to strike a chord
WHAT MADE YOU WANT TO OPEN STRING THEORY GUITARS INC.? ALLISON & LEE WILLIAMS: “We are lifelong musicians with a passion for playing. We love Wilmington and the live music scene here, and we wanted a way to be a part of the music community without having to start work at 9 p.m. We also want to be a destination for residents and musicians performing in and around the downtown area.” WHAT DOES YOUR BUSINESS PROVIDE, AND HOW DO YOU THINK IT HELPS CUSTOMERS? We love Wilmington and the live music scene here, and we wanted a way to be a part of the music community without having to start work at 9 p.m. We also want to be a destination for residents and musicians performing in and around the downtown areaTHE WILLIAMSES: “We’re a true basics-to-boutique destination. If you’re someone who’s just starting out, we can set you up with high-quality, brand-new equipment at a great entry-level price point. When you’re ready for your dream guitar, we can help you design and create a fully custom electric or acoustic guitar to your specifications. We have a broad selection of both guitars and amplifiers for players of every level. We also have a community board in the store to connect bands, students, instructors, repair technicians, and anyone providing a service to the local music community.” WHAT PAST EXPERIENCE DO YOU HAVE THAT LED YOU TO CREATE STRING THEORY GUITARS? THE WILLIAMSES: “Lee has played guitar for almost 40 years, from middle school band to gigging rock bands. Allison has a background in orchestra and musical theater, as well as retail management. We worked together as a husband-and-wife team in manufacturing for many years prior to moving to Wilmington. Having shopped in countless music stores over the years, we set up our shop with the goal of being welcoming and inviting. Our philosophy is ‘if it’s on display, it’s for play.’ No instrument or amplifier is out of reach in our store.” WHAT GOALS DO YOU HAVE FOR GROWTH? THE WILLIAMSES: “We would love to grow the bluegrass and folk instrument segment of our business. We carry banjos, mandolins, resonator guitars, ukuleles and related accessories. We’ve seen and heard plenty of talented bluegrass and folk musicians around Wilmington, and we look forward to expanding our selections to support this growing segment of the local music scene.” WHAT CHALLENGES ARE YOU FACING RIGHT NOW IN YOUR BUSINESS? THE WILLIAMSES: “Getting the word out about our brand and some of the unique brands we represent is a challenge for any new business. Online exposure through the Cargo District, Wilmington Downtown Inc. … and our online following is steadily growing. Our other challenge is the logistics of our streets. Our neighborhood is amazing, and you could spend the entire day walking around the Cargo District. As the District continues to grow, we’re seeing more pedestrian traffic, particularly in crossing 16th and 17th streets. We’ve seen some improvements in traffic calming, but the sooner we can improve safety with crosswalks and pedestrian signals, the more welcoming our neighborhood will be.”
Meet a Health Hero Finalist: Sharon Pervez-Khan
After her daughter Elora was diagnosed with an incurable, cancerous brain tumor, the Villanova mom made it her mission to accelerate research, funding, and life-saving treatment.
EverTrue Acquires Aidentified's Philanthropy Business, Securing Exclusive Data Rights to Advance AI-Powered Fundraising
/PRNewswire/ -- EverTrue, the philanthropy-first intelligence platform for fundraising teams, today announced an exclusive partnership with Aidentified, a data...
September 9 Playbook: “Trumpapalooza”
🏈 It’s a Football Wednesday. The NFL season starts tonight 🎶 Your Morning Pick Me Up. NFL on NBC Sunday Night Theme. Champions United PA Weather🌂 Bradford | Chance of Showers, 81🌤️ Mount Carmel | Partly Sunny, 82☀️ Ambler | Mostly Sunny, 87 PA Sports ⚾ Phillies (81-64, -4.0 GB, +3.5…
Dolly Parton remembered in new 28-page tribute comic book
The country music superstar, entrepreneur and philanthropist died Aug. 25
Phillies news: Aidan Miller, bullpen, expansion
C’mon man, this is how they’re gonna play?
Sept. 9 - Savannah Philharmonic Announces Upcoming Phil the Neighborhoods Series
September 9, 2026 - The Savannah Philharmonic will present their annual Phil the Neighborhoods fall series. This annual concert series brings residents and families together through music.
Parkinson demands more from Wrexham after draw
Manager Phil Parkinson acknowledges Wrexham have room for improvement after they were held to a 1-1 draw at home by Burnley.
Eagles' Tanner McKee Continues Being Top Trade Candidate
Philadelphia Eagles quarterback Tanner McKee continues to be named a top NFL trade candidate.
Ex-Philadelphia Phillies Player Cut Loose By New MLB Team
As the Philadelphia Phillies are currently taking on the Houston Astros in a new series this week, a piece of notable roster news dropped on a recent Phillies player. Phillies fans shouldn’t have forgotten by outfielder Max Kepler yet, as Kepler played his entire 2025 season with Philadelphia. Well, on Tuesday, Kepler was released by […] The post Ex-Philadelphia Phillies Player Cut Loose By New MLB Team appeared first on HEAVY.
Commanders’ Sonny Styles Gets Strong Prediction Before Eagles Game
The Washington Commanders will look to get off to a 1-0 start when they face the Philadelphia Eagles in Week 1 on Sept. 13. After missing the playoffs last season, the Commanders are looking for a bounce-back campaign.One of the young players the team will be counting on is linebacker Sonny Styles, whom they took […] The post Commanders’ Sonny Styles Gets Strong Prediction Before Eagles Game appeared first on HEAVY.
SMARTIES Philippines 2026 Finalists Revealed: Celebrating Hyper-Local Innovation and Business Impact
Marketing + Media Alliance (MMA) has officially announced the SMARTIES Philippines 2026 Finalists. This year's shortlist recognizes campaigns blending cultural insights with emerging technologies to navigate evolving consumer behaviors and deliver measurable business impact.
LeBron James is partnering with prediction platform Polymarket
PHILADELPHIA — Where LeBron James would choose to play the final years of his storied career was a fixture on prediction markets this summer. Now, James could benefit from the
Man sentenced after breaking child's fingers while working for health facility
A man is avoiding jail time after breaking a child's fingers in 2025 and not reporting the injuries while working for KidsPeace, officials said.
Hundreds protest plans to close Philly's Academy of Natural Sciences: "We're going to make our voices heard"
More than 200 registered nurses at Jefferson Health in Greater Philadelphia announce plans to unionize
Nurses at Jefferson Bucks Hospital, Einstein Center One and Jefferson Health Willowcrest plan to join PASNAP.
Marin dermatologist dances on edge of show business
Dr. David Laub, a practitioner in Mill Valley, satisfies dual interests in dance and philanthropy.
Why Brandon Marsh's slump will derail Phillies' NL East chances
The Philadelphia Phillies are looking to surpass the Atlanta Braves in the National League East standings. They will need players to step up over the next few weeks amid their pursuit of winning the division. Of course, Philadelphia is hoping its stars can lead the way. Starting pitching is a strength for this Phillies ball club. Zack Wheeler has […] The post Why Brandon Marsh's slump will derail Phillies' NL East chances appeared first on ClutchPoints.
Protesters rally against Academy of Natural Sciences closure
Protesters rallied outside the Academy of Natural Sciences Tuesday as the 198-year-old Philly museum prepares to close at the end of September.
Orchard Place names Haselhuhn vice president of advancement
Orchard Place has named Adam Haselhuhn its new vice president of advancement, effective Sept. 14. Haselhuhn has more than 14 years of experience in higher education and healthcare philanthropy, most recently serving in senior development leadership roles at the John Stoddard Cancer Center and UnityPoint Health – Des Moines Foundation. He previously served as director…
Flyers Confirm Major New Arena News
After nearly three decades of playing at the historic Spectrum in South Philadelphia, the Philadelphia Flyers and 76ers moved into Xfinity Mobile Arena (originally called CoreStates Center) in 1996.The upcoming campaign will the be 30th season that both teams call the venue home, but that won’t be the case much longer. Renderings have been released […] The post Flyers Confirm Major New Arena News appeared first on HEAVY.
Philz Coffee workers in California file to form union to negotiate new contract
The notice was delivered Tuesday
Game Awards Host Geoff Keighley And PlayStation Architect Mark Cerny Will Start Giving $2 Million To Young Game Designers Each Year
The Nova Games Foundation is a new philanthropic initiative aimed at supporting the next generation of game makers
At rally to save Academy of Natural Sciences museum, protesters urge Drexel to 'act like it's an emergency'
Local lawmakers and scientists outlined several options to preserve the museum, which is due to close Sept. 30.
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Florida business owner arrested after employees find hidden camera in bathroom: sheriff
NEW SMYRNA BEACH, Fla. (WFLA) — A Florida man was arrested on Monday after it was revealed that he hid a small camera inside an electrical outlet in the bathroom of his business. Donald Hemphill, 5…
Nurses throughout Jefferson Health System announce plan to unionize
More than 200 nurses throughout the Jefferson Health System plan to file to unionize, organizers said during an event on Tuesday.
Atlanta Braves Announce Pitcher News Before Rays Series
After splitting their four-game series with the Philadelphia Phillies, the Atlanta Braves remain 4.0 games up in the NL East. No off day for Atlanta, as they head home to face the AL East-leading Tampa Bay Rays in a new series this week. It’s another big litmus test for the Braves, as the series’ on […] The post Atlanta Braves Announce Pitcher News Before Rays Series appeared first on HEAVY.
Eagles Reporter Reveals How Philly Can Win NFC East Again
How can the Eagles win the NFC East again? A Philly reporter knows how.
Eagles legend Brandon Graham announces retirement after 16 seasons
Brandon Graham announced his retirement for a second time, ending a franchise-record 16-season career spent entirely with the Philadelphia Eagles
Rally held to keep Philadelphia's Academy of Natural Sciences museum open
Protesters held a rally Tuesday calling for officials to save the Academy of of Natural Sciences museum in Center City Philadelphia.
Hidden camera found in bathroom of Volusia County pet daycare business, owner arrested, deputies say
The owner of a pet daycare and boarding facility in Volusia County has been arrested after a hidden camera was found in the facility's bathroom, according to the Volusia County Sheriff's Office.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Projecting the Eagles’ starting defense against Washington in Week 1
Projecting Vic Fangio’s defensive starters for Philadelphia’s Week 1 matchup.
Dan Stevens and Gabriel Luna are the new killers on the block in season 2 of “Dexter: Resurrection” (exclusive)
Showrunner Clyde Phillips previews the emergence of the two new serial killers, as well as the shocking return of Krysten Ritter.
Florida IAM Members Focus on Political Mobilization at Fall Conference
The IAM's Florida State Council recently held its fall conference, bringing together union leaders and delegates to focus on political education, voter mobilization, and strengthening the voice of working families across the state. Led by President Mike Phillips, the conference emphasized the importance of supporting pro-labor candidates and increasing member participation in the political process.
First Renderings Of New Philadelphia Arena Inspired By The Spectrum
Planned 2030 opening includes an outdoor plaza and opportunities for an expanded restaurant experience at the South Philadelphia location
Bailey Stockton reflects on special touchdown from Aaron Philo
Bailey Stockton discussed reuniting with Aaron Philo, scoring in his Florida debut and the Gators' offensive potential entering Week 2.
Meet a Health Hero Finalist: Lyndsay Hoy
The Penn-affiliated anesthesiologist lives with a rare, progressive lung disease known as lymphangioleiomyomatosis (LAM). Here's how she's working to advance research and support others living with LAM.
September 8 Playbook: Fetterman Hits Back
🥱 Welcome Back. Hope you enjoyed your holiday weekend. 🎶 Your Morning Pick Me Up. Welcome Back. John Sebastian PA Weather☀️ Erie | Mostly Sunny, 77🌤️ State College | Partly Sunny, 81☀️ Allentown | Mostly Sunny, 81 PA Sports ⚾ Phillies (81-63, -4.0 GB, +4.5 GB WC) | Atlanta 1-0 |…
76ers, Flyers Unveil First Look at New Arena Designed to Shape the Future of Philadelphia Sports and Entertainment
Scheduled to open in 2030, the arena is designed to deliver a next-generation fan experience and amplify the energy of Philadelphia sports, concerts, live entertainment and community programming.
Arena for 76ers, Flyers marks 'new era for Philadelphia sports'
The 76ers and Flyers have unveiled renderings of their new fully privately funded arena in South Philadelphia, which is targeted to open before the WNBA season in 2030.
Arena for 76ers, Flyers to open in 2030, marks 'new era'
The 76ers and Flyers have unveiled renderings of their new fully privately funded arena in South Philadelphia, which is targeted to open before the WNBA season in 2030.
Orioles news: O’s snap six-game skid
The O’s pulled within three games of the Guardians with a series-opening win, but an uphill battle remains.
How Jalen Hurts showed he embraced Eagles' new offense
Jalen Hurts has embraced the Eagles’ new offense. Parks Frazier explains how he knew.
Minnesota business leaders are captivated by this philanthropy manual
Why a new book by Bush Foundation’s Jen Ford Reedy is resonating.
Projecting Eagles’ defensive depth chart entering Week 1
Projecting Philadelphia's defensive depth chart for Week 1.
CCRES Real Job Preview: Behavioral Health Industry Challenges
CCRES employees discuss the challenges of behavioral health careers and how teamwork helps students communicate and regulate emotions.
CSU biology professor delivers talk on extremophilic microorganisms, research advancements
Thomas Santangelo began the department of biology’s fall semester seminar series at Colorado State University strong, presenting the progressive research behind microorganisms in extreme environments and how those observations can inform future research about biological resilience and adaptation. Santangelo, a professor of biochemistry and molecular biology at CSU, was the main speaker of the “Surprises...
Phillies Handed Major Injury Update on Impact Left-Handed Pitcher
The Philadelphia Phillies could soon get Tanner Banks back into the fold as they got a positive injury update during the Braves series. The post Phillies Handed Major Injury Update on Impact Left-Handed Pitcher appeared first on HEAVY.
Cowboys Announce Injury Update That Could Impact Eagles Game
The Dallas Cowboys have suffered a major injury ahead of Week 1 of the 2026 NFL season. The Philadelphia Eagles are certainly taking notice of the situation. According to ESPN’s NFL insider Adam Schefter, the All-Pro left guard Tyler Smith suffered a thumb injury this offseason. As a result, the star lineman will undergo surgery. […] The post Cowboys Announce Injury Update That Could Impact Eagles Game appeared first on HEAVY.
Protesters push to stop Academy of Natural Sciences from closing museum
A protest is set to take place outside the Academy of Natural Sciences of Drexel University on Tuesday, Sept. 8, to stop the closure of the museum.
Eagles Projected to Have Worse Record in 2026 Than 2025
The Philadelphia Eagles are projected to have a worse record in 2026 than in 2025.
Atlanta Braves Announce Ha-Seong Kim Decision During Phillies Series
The Atlanta Braves have already, at the very least, split this four-game series with the Philadelphia Phillies. However, they can clinch the series victory Monday and take three of four games, which would extend their division lead over the Phillies to six games. Atlanta currently holds a five-game lead after Sunday’s comeback victory. Ahead of […] The post Atlanta Braves Announce Ha-Seong Kim Decision During Phillies Series appeared first on HEAVY.
Follow U-T business reporter in S. Korea as he navigates digital kiosks, gets a style makeover, finds a San Diego connection
Business reporter Phillip Molnar explores ties between South Korea and San Diego.
Howie Roseman explains why Eagles drafted Jihaad Campbell
Jihaad Campbell’s ability to cover, blitz and rush made him valuable to the Eagles
How the Eagles could divide carries behind RB Saquon Barkley
How the Eagles could divide carries behind Saquon Barkley with Tank Bigsby and Will Shipley offering different skill sets