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Why So Many Social Science Claims Are False
One of the most urgent questions facing society today is the potential impact of AI on education and labor markets. So it’s no surprise that two scientists attempted to provide
Spain's housing crisis bursts into the spotlight at snap election
Spain's snap election will revolve around an issue which has topped voters' list of concerns for three years straight but, until a fortnight ago, failed to dominate the political debate: housing.
Kyle Pitts tallies season-high 47 yards receiving
Kyle Pitts surpassed his season-to-date totals in both receptions and yards against the Saints on Monday night.
DAI acquires 31 home health and hospice agencies from HCA in 'unique opportunity'
Faith-based not-for-profit organization Deaconess Associations Incorporated (DAI) has finalized the acquisition of 31 home health and hospice agencies across eight states from HCA Healthcare.
The Best October Prime Day Apple Deals on AirPods, MacBooks, and More
Many Apple’s products are pricier than ever, but we’ve found some decent Prime Day deals on AirTags, AirPods, Apple Watches, and more.
Carson Daly returning for huge “TRL” reunion special with surprises in store — and it’s not for MTV (exclusive)
EW has exclusively learned that Daly will return to reunite with major “TRL” personalities and music stars in the original Times Square studio.
Carson Daly returning for ‘TRL’ reunion special — but it’s not on MTV (exclusive)
Carson Daly will return for a ‘TRL’ reunion special recorded at the MTV Times Square studio where ‘Total Request Live’ used to air. Major surprises are in store for the Roku special.
Champion Homes grows via another acquisition
Troy-based Champion Homes has acquired an Alabama-based manufactured housing company with nine retail locations around the south.
DHS buys 2 more detention centers in California for $950 million
WASHINGTON — The Department of Homeland Security has purchased two immigrant detention facilities in Adelanto for $950 million, according to the private prison corporation that sold them. The sale by
Olivia Dean song lifted from Bill Withers hit, complaint alleges
A complaint recently filed in California alleges that Grammy winner Olivia Dean's song 'I've Seen It' lifts from Bill Withers' lasting hit 'Just The Two of Us.'
Chargers' Omarion Hampton numbers may shock you after four weeks
These Chargers running back Omarion Hampton's stats may surprise you over the first four weeks of the season.
Legends Radio spotlights JB Berkow’s lifelong art passion
JB Berkow is the founder of Benzaiten Center for Creative Arts in Lake Worth Beach. LEGENDS RADIO / COURTESY PHOTO This week's Legends Radio Local Artist Spotlight shines on accomplished artist and passionate advocate for the arts, JB Berkow. For more than five decades, JB Berkow has dedicated her life not only to creating art but also to making sure art has a place to thrive. Her work has been exhibited throughout the country in galleries, museums, and universities, and is held in permanent collections, including the Vatican’s Contemporary Art Collection in Italy, Boston University, and Palm Beach International Airport. Her passion for supporting other artists began early. At age 26, Berkow founded Touchstone Gallery in Washington, D.C., which became a highly successful cooperative gallery. She later brought that same entrepreneurial spirit to South Florida, founding Frenchman’s Art Gallery and Studios in Juno Beach in 1995. She opened Rosetta Stone Fine Art Gallery in 2003. In 2015, JB took her commitment to arts education even further by founding the nonprofit Benzaiten Center for Creative Arts. The 15,000-square-foot facility in Lake Worth Beach is home to Florida’s largest publicly accessible glassblowing hot shop and offers instruction in glassblowing, fusing, flameworking, and glass casting. The center also provides free classes to approximately 1,000 underserved children and young adults with disabilities each year. Its “Fragments Reimagined” art therapy program for veterans with PTSD recently received a $100,000 Impact 100 grant. In addition to her work as an artist and advocate, Berkow has authored four books, including Shades of Love and What They Didn’t Teach You in Art School. For JB, art has always been about more than creating something beautiful. It’s about opening doors, inspiring others, and making creativity an important part of life.That is why JB Berkow is in this week’s Legends Radio Local Artist Spotlight.
MSSM to Host Public STEM Night
The Maine School of Science and Mathematics in Limestone is hosting a STEM Discovery Night tonight.
UK author and politician Jeffrey Archer dies aged 86
Jeffrey Archer, the best-selling British novelist and former politician who was jailed for lying in a high-profile libel case, has died aged 86, his publisher HarperCollins said on Monday.
Tony Gilroy on leaving the politics of 'Andor' behind for his 9-composer music drama 'Behemoth!'
Tony Gilroy’s “Behemoth!” premiered over the weekend as the centerpiece of the New York Film Festival. Gilroy’s first film since the Star Wars series “Andor” concluded its acclaimed two-season run,
NYC Health + Hospitals/Queens Hosts Community Health Fair as Centerpiece of Hispanic Heritage Month Celebrations
NYC Health + Hospitals/Queens hosted a comprehensive Community Health Fair on September 30, serving as the primary event in the hospital’s month-long
Trump’s midterm messaging undercuts GOP candidates
Many Republican candidates have found themselves in surprisingly competitive races
Trump’s midterm messaging undercuts GOP candidates
Many Republican candidates have found themselves in surprisingly competitive races
El-Sayed explains what he means by getting the money out of politics
Michigan Democratic Senate nominee Abdul El-Sayed details his Medicare for All plan while advocating for politicians to not take money from big corporations on ‘The Story.
Your Brain Under Anesthesia Behaves Surprisingly Like a Worm's, Scientists Discover
A shared experience of oblivion.
Chip City closes all locations amid economic challenges
Chip City, a New York City-based gourmet cookie chain, has closed all 22 remaining locations nationwide due to tough consumer spending and evolving preferences.
Mass. business confidence rises in September but remains pessimistic
Massachusetts business confidence rose modestly in September after a sharp decline in August.
Enterprise Veteran to Mentor Oregon Consulting Group
Oregon Executive MBA alumnus Todd Grigsby, MBA ’00, has joined the University of Oregon as Professor of Practice and faculty director of the student-run Oregon Consulting Group (OCG) at the Lundquist College of Business.
Yes on Prop 2: How We Can Get Money Out of Michigan Politics!
This November, Michiganders can vote yes on Prop 2 and get corporate spending — including by the data center industry — out of our politics.
Is It Smart To Buy Science Applications International Corporation (NASDAQ:SAIC) Before It Goes Ex-Dividend?
Regular readers will know that we love our dividends at Simply Wall St, which is why it's exciting to see Science...
Andoni Iraola pushed closer to finally signing Mohamed Salah's successor
Mohamed Salah exiting Liverpool was one of the biggest stories to emerge from Anfield this summer.His fallings out with Arne Slot eventually became too much and, even though he had a year left on his ...
Supreme Court weighs local governments' climate lawsuits against oil, gas firms
Key justices appeared wary about the potential sweep of litigation, but torn over the complex legal interplay of federal and state laws raised by the case
Supreme Court weighs local governments' climate lawsuits against oil, gas firms
Key justices appeared wary about the potential sweep of litigation, but torn over the complex legal interplay of federal and state laws raised by the case
NBA Scout Calls Jalen Duren an Overpaid Role Player
An anonymous NBA scout had a blunt verdict on what Detroit just paid Jalen Duren. #Pistons
Apple Releases Third iOS 27.2 Beta
Apple today seeded the third beta of an upcoming iOS 27.2 update to developers for testing purposes, with the update coming two weeks after Apple released the second iOS 27.2 beta. Apple also seeded a new iPadOS 27.2 beta. Registered developers can download the beta updates by opting in under Settings > General > Software Update and selecting the iOS 27 developer beta. iOS 27.2 includes Apple's redesigned Health app with new Insight and Longevity tabs.
Mundelein resident chosen as finalist in Advocate Health Has Talent competition
Mundelein resident Gerardo Ocampo was driving his wife and child home from the airport when he received a call from his supervisor at Advocate Condell Medical Center.
G-Shock's Most Expensive Watch Ever Gets a Way More Affordable Everyday Edition
While sharing the same inspiration and iconic square case, this new edition costs over 99 percent less, making it far more accessible.
Pokémon GO Halloween 2026: Part One
Pokémon GO’s Halloween 2026 Part One event runs from October 27 at 10:00 a.m. to November 1 at 10:00 a.m. local time, bringing three new costume Pokémon: Pikachu wearing a hat and capelet, Zubat wearing a top hat, and Sinistea wearing a bow! Expect spooky wild encounters, costume raids, and trick-or-treat surprises that can reward […]
Senate clears bipartisan bills on aviation worker mental health
Sen. Tammy Duckworth says pilots and other workers need to be able “to take care of themselves without fearing for their job security.”
Steelers Sign Super Bowl Champion Cornerback
The Pittsburgh Steelers are signing veteran cornerback Sean Murphy-Bunting off the Tampa Bay Buccaneers’ practice squad, according to NFL insider […]
Top Iranian official admits dire state of the economy: Report
A top Iranian official reportedly admitted that Iran’s economy is in dire straits due to the war and the U.S. blockade of the country. Mohsen Rezaei, secretary of the Supreme National Security Council and former commander in chief of the Islamic Revolutionary Guard Corps, made the admission Saturday at a high-level government meeting focused on […]
Lewis Ginter Botanical Garden cancels health coverage for striking employees
Striking employees of the Lewis Ginter Botanical Garden are being removed from the nonprofit's healthcare plan, according to a letter from the garden. Lewis Ginter wrote to CBS 6: "The law does not require employers to continue paying wages or unaccrued benefits to striking workers who are not actively
The upcoming D&D interpretation of World of Warcraft sounds great, but don't expect it to work like the MMO does
World of Warcraft is being given the Dungeons & Dragons treatment in a massive new book. But D&D: WoW works quite differently to the MMO.
Angels To Face Decision On Ill-Fitting First Baseman
Nolan Schanuel’s elite contact skills contrast sharply with a glaring lack of power, forcing the Halos to weigh his high-floor production against more traditional middle-of-the-order threats.
Dungeons and Dragons: World of Warcraft – Everything You Need to Know
Dungeons and Dragons: World of Warcraft was announced way back in July, as the first Universes Beyond release for the storied tabletop RPG. And just like the MMO it's based on, D&D: World of Warcraft is absolutely massive.
Mary McNamara: As David Ellison names his new empire Skydance, the message is clear: He owns Hollywood
LOS ANGELES — What a surprise. David Ellison has decided to name the Frankenstudio media company created by the merger of Paramount Skydance and Warner Bros. Discovery simply Skydance. And
Behind the Seams | Wildwood
Go behind the scenes at LAIKA Studios for an up-close look at the extraordinary costumes of ‘Wildwood,’ the studio’s most intricately designed stop-motion film yet. Nearly 20 years after ‘Coraline,’ LAIKA’s artists and designers reveal how every tiny stitch, button and layer of fabric is handcrafted and engineered to help bring its puppets to life, combining costume design, fabrication and animation at an astonishing scale.
Caring for students a priority at Health Center
A primary purpose of the Campbell University Health Center is caring for students, serving as an important resource in regard… More on this post
Small Businesses Skip the Cross-Border Plumbing Big Companies Can’t Escape
Conventional wisdom says large corporations should dominate cross-border payments. They have global banks, treasury teams, negotiated FX rates,
Spurs employ three-guard lineup during Silver & Black Scrimmage
De'Aaron Fox, Stephon Castle and Dylan Harper played together in what coach Mitch Johnson called "on-the-job training."
Florida earns 'F' grade from CBS Sports after Missouri beatdown
Unsurprisingly, Florida football earned a failing grade from CBS Sports for its performance against the Missouri Tigers on the road in Week 5.
Misericordia University to Host Healthcare Symposium with Presenting Sponsor Geisinger
Misericordia University’s College of Health Sciences and Education, with Geisinger as Presenting Sponsor, will host the 2026 Healthcare Symposium, “Connected Care: Aligning Education, Innovation & Community Health,” on Friday, Oct. 23, from 8 a.m. to 5 p.m. in Lemmond Theater on the University’s Dallas campus.
Lawrence brothers take on missing ’90s stars in graphic novel, ‘The Lawrence Brothers Detective Agency’
Joey Lawrence and his brothers, Matthew and Andrew, take on missing ’90s stars and nostalgia prisons in the new graphic novel, ‘The Lawrence Brothers Detective Agency.’
Can we harness the brain's deep-cleaning system to prevent Alzheimer's?
The glymphatic system is the brain's recently discovered network for flushing out toxins. Now, we're uncovering surprising ways to boost it to protect brain health
DHS buys three detention centers in California for $950 million
The GEO Group, a Florida-based private prison corporation, announced Monday that it had sold the detention facilities, including the Adelanto ICE Processing Center, totaling 2,644 Beds.
DAI Closes HCA Hospice, Home Health Transaction
Deaconess Associations Incorporated (DAI) has closed its acquisition of 31 home health and hospice agencies from HCA Healthcare (NYSE: HCA).
Weaner Pig Breakeven at $22.46, Up $12.25 From Last Week
When you consider that today’s purchased weaner would be sold in March 2027 using April 2027 futures, the weaner breakeven was $22.46, up $12.25 for the week, and $0.57 below the average cash price for the week of $23.03.
Seedy K’s Pigskin Palaver: House of Cards & Much Mo’
Ah yes, October; the pigskin campaign is morphing more fully developed. And, fully enveloping. This week, there’s a football game on every single night. Not just the more traditional Thursday, Friday, Saturday, Sunday, Monday. Because Draft Kings and Fan Duel and The World Wide Leader need content, we get Southern Miss and Troy on Tuesday, […]
Nobody remembers your EBITDA at your funeral
David Mammano highlights the importance of balancing profit with purpose in business to build companies that employees, customers, and communities value.
Science Corp. Announces Long-Term (36 Months) Results of PRIMA BCI Clinical Trial Showing Durable Vision Restoration in Blind Patients Suffering from Geographic Atrophy
Science Corporation, the neural engineering and brain-computer interface (BCI) company, today announced long-term (36 months) followup data from its pivotal ...
More than a prescription: Removing barriers so patients can get back to living
See how integrated specialty pharmacy support helped one patient overcome treatment barriers and get back to the moments that matter most.
Lexology Index Recognizes Five Hecker Fink Partners in 2026 Business Crime Defence Guide
Hecker Fink Partners Shawn Crowley, Jenna Dabbs, Mike Ferrara, Sean Hecker, and Amy Jeffress have been recognized in the Lexology Index guide for Business Crime Defence. The 2026 guide honors leading lawyers worldwide who “stand out among peers for their exceptional work representing companies, corporate officers, and individuals in criminal litigation arising from their business activities.”
Tech billionaires are spending millions to reshape California’s Legislature
Tech billionaires funding PACs have enjoyed recent growth in personal and corporate wealth and are spending it to handpick the Legislature.
Galaxy S27 Ultra colors leak, and Samsung could be breaking up with purple
Leaked Galaxy S27 Ultra colors suggest Samsung is retiring Deep Purple for another, surprising shade of color.
Earth Shifted Quickly On Its Axis Four Times In Last 320 Million Years, Including When Dinosaurs Reigned
Frankly, it’s surprising the dinosaurs didn’t get dizzy.
Kingdom Hearts I-III for Switch 2 should've been a slam dunk, but some games need more work
The inconsistent port quality and issues hold some of these KH games back on Switch 2. Square Enix should've done more.
Two More Games Revealed For Xbox Game Pass In 2026, Including A Surprise Shadow Drop
It's coming home
Phillies news: Bryce Harper, Bryson Stott, Kyle Schwarber
I’d like to see Munetaka Murakami hit another home run tonight
Integral Ad Science to Provide Brand Safety and Suitability Measurement in ChatGPT Ads
NEW YORK, October 05, 2026--As artificial intelligence rapidly reshapes digital advertising, marketers face a critical new challenge: ensuring brand safety and suitability within dynamic, generative AI-native environments. Without independent verification, advertising in conversational channels risks creating a blind spot for enterprise brands seeking reliable media quality standards.
The 2026 Lookout List: Health and Wellness
Are you feeling centered? This is a place where we value having aligned chakras, purposeful movement, a good gym to frequent and a good dispensary to drop into (for those that partake). For our Health and Wellness category of the Lookout List, we asked you for the best spots to drop into for yoga, mindful moments, health food and more.
After success in Ascension with steel plant, Iberville Parish proposes its own industrial zone
Proposed industrial area would abut the RiverPlex MegaPark in Ascension, which has drawn billions in investment and pollution concerns
WISeSat.Space Completes Business Combination and Begins Nasdaq Trading
WISeSat.Space has completed its business combination with Columbus Acquisition Corp. and started trading on Nasdaq as SAIQ.
Jobs in health care. Jobs for women. The US labour market is segmenting. Chernobyl’s radiation and Lenin’s love of literature.
Thank you for opening your Chartbook email. Elmer Bischoff, Two Figures at the Seashore, 1957 The only really dynamic job-creator in the US economy is health care: The largest crunch has come in Federal government, which has shed 2.7 m jobs. Source: tchouvkov on Twitter Tech is struggling. [ Joey Politano 🏳️🌈@JosephPolitano The US tech sector continues bleeding jobs in official data released today—overall, employment decreased by 17k last month and is down 69k over the last year That's nearly as bad as the worst of the 2024 tech-cession, and much worse than the 2022 boom or even pre-2020 norms 12:42 PM · Oct 2, 2026 · 15.2K Views 15 Replies · 47 Reposts · 390 Likes ](https://x.com/JosephPolitano/status/2106001807847940232?s=20) The new jobs are all for women. [ Justin Wolfers@JustinWolfers I'm not sure who saw this coming, but so far nearly all the jobs created during the second Trump administration have gone to women. 1:09 PM · Oct 2, 2026 · 33K Views 70 Replies · 146 Reposts · 644 Likes ](https://x.com/JustinWolfers/status/2106008723533533601?s=20) Meanwhile, real wages are being eaten up by modest over-target inflation. [ Heather Long@byHeatherLong The financial pain is real: Wage growth fell to 3% (y/y) in September. That's the lowest in 5 years. Wage growth: 3% Inflation: ~3.4% Inflation has eaten up all wage gains for the average worker since April. Many people are having to make hard choices about what to buy and what … 1:24 PM · Oct 2, 2026 · 37K Views 24 Replies · 275 Reposts · 533 Likes ](https://x.com/byHeatherLong/status/2106012367712620728?s=20) HEY READERS, THANK YOU for opening the Chartbook email. I hope it brightens your day. I enjoy putting out the newsletter, but tbh, what keeps this flow going is the generosity of those readers who clicked the subscription button. If you are persuaded to click, please consider the annual subscription of $60. It is both better value for you and a much better deal for me, as it involves only one credit card charge. Why feed the payments companies if we don’t have to. Subscribe Elmer Bischoff, Bathers, 1960 Americans are disillusioned with higher ed. For contributing subscribers only. Subscribe Where the Chernobyl radiation went. h/t Simon Kuestenmacher aka simongerman600 How Lenin’s love of literature shaped the Russian Revolution - Tariq Ali This, then, was the intellectual atmosphere in which Lenin came of age. His father, a highly cultured conservative, was the chief inspector of schools in his region and much respected as an educationalist. At home, Shakespeare, Goethe and Pushkin, among others, were read aloud on Sunday afternoons. It was impossible for the Ulyanov family – “Lenin” was a pseudonym adopted to outwit the tsarist secret police – to escape high culture. At high school, Lenin fell in love with Latin. His headteacher had high hopes that he might become a philologist and Latin scholar. History willed otherwise, but Lenin’s passion for Latin, and taste for the classics, never left him. He read Virgil, Ovid, Horace and Juvenal in the original, as well as Roman senatorial orations. He devoured Goethe during his two decades in exile, reading and rereading Faust many times. Lenin put his knowledge of the classics to good use in the time leading up to the October revolution of 1917. In April of that year, he broke with Russian social-democratic orthodoxy and, in a set of radical theses, called for a socialist revolution in Russia. A number of his own close comrades denounced him. In a sharp riposte, Lenin quoted Mephistopheles from Goethe’s masterwork: “Theory, my friend, is grey, but green is the eternal tree of life.” Source: The Guardian Elmer Bischoff, The River, 1953 If you’ve scrolled this far, you know you want to click: Subscribe
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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