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Disney’s Rita Ferro, Inde Navarrette and Melissa Barrera on Latina Powerhouse 100 List From ¡HOLA! Américas
Disney advertising chief Rita Ferro, “Obsession” star Inde Navarrette and actor Melissa Barrera are among the entertainment industry notables featured on the Latina Powerhouse 100 list published today...
Sunday Science talk to focus on aircraft safety
“Aircraft Design and Operation for Safety” is the title of the next Sunday Science talk presented by the Central Colorado Humanists at 10 a.m. Nov. 1 at A Church, 419
Rhode Island FC hires Lou DePaoli as president of business operations
DePaoli said he intends to prioritize making Centreville Bank Stadium, which currently operates about 50 dates annually, a year-round entertainment destination.
The PAW Patrol® unleash their superpowers in Nickelodeon and VStar Entertainment Group’s newest live stage show PAW Patrol™ Live! “A Mighty Adventure” at the Fox Theatre March 26 and 27
(DETROIT – October 26, 2026) – Nickelodeon and VStar Entertainment Group proudly present PAW Patrol™ Live! “A Mighty Adventure.” The latest live stage show takes fans on a super-powered adventure inspired by PAW Patrol:
Side expands presence in China, opens new studio and acquires art outsourcing provider Roboto Entertainment
Roboto Entertainment founder Andrea Cordella appointed global head of art and studio head for new Chengdu office
“Big Brother” winner Rick Devens’ wife announces breast cancer diagnosis: ‘Send good vibes and prayers’
“Rick won ‘Big Brother’ and then we came home and I got diagnosed with breast cancer.”
Mariska Hargitay reveals several interviews didn’t make it into “My Mom Jayne ”documentary
“I could have made so many films.”
“Big Brother” producers address whether more reality icons will be returning for season 29
Are familiar faces on the way next summer?
Dan Rather, Wavelength, Original Productions and Anchor Entertainment Partner to Make RATHER Documentary Free to Stream on YouTube Beginning Monday, October 26, in Support of Independent Journalism and Free Speech
Directed by Frank Marshall, RATHER explores the evolution of American journalism through the life and career of Dan Rather.
Intermountain Health wants women to prioritize mammograms with simplified online scheduling
Thanks to recent upgrades at Intermountain Health, it's easy for women to schedule an appointment for their annual screening mammogram.
Ventola Projects returns to IAAPA Expo Orlando with innovative solutions for entertainment venues
Ventola Projects is preparing to return to IAAPA Expo 2026 in Orlando, Florida, taking place from November 16–20 at the Orange County Convention Center. The company will be showcasing its latest VA…
JYP Entertainment Denies Stake Acquisition Rumors
JYP Entertainment Denies Stake Acquisition Rumors
“Breaking Bad” star RJ Mitte’s sister pays tribute to late brother: ‘I just lost my other half’
Lacianne Carriere shared photos and videos from her brother’s life on Instagram.
Progress being made on Prisma Health Performance Center in Greer
FOX Carolina's Scottie Hunter has the details.
Progress being made on Prisma Health Performance Center in Greer
FOX Carolina's Scottie Hunter has the details.
Progress being made on Prisma Health Performance Center in Greer
FOX Carolina's Scottie Hunter has the details.
Progress being made on Prisma Health Performance Center in Greer
FOX Carolina's Scottie Hunter has the details.
Progress being made on Prisma Health Performance Center in Greer
FOX Carolina's Scottie Hunter has the details.
Progress being made on Prisma Health Performance Center in Greer
FOX Carolina's Scottie Hunter has the details.
Progress being made on Prisma Health Performance Center in Greer
FOX Carolina's Scottie Hunter has the details.
Progress being made on Prisma Health Performance Center in Greer
FOX Carolina's Scottie Hunter has the details.
Progress being made on Prisma Health Performance Center in Greer
FOX Carolina's Scottie Hunter has the details.
Progress being made on Prisma Health Performance Center in Greer
FOX Carolina's Scottie Hunter has the details.
Food Safety Risk Assessment: How Scientists Evaluate Chemical and Microbial Hazards
Food safety risk assessment combines evidence about chemical toxicity and microbial hazards with dietary exposure estimates to evaluate potential health effects. Scientists account for combined exposures, susceptible populations, and uncertainty to guide monitoring, regulation, and preventive measures.
D. C. Circuit Review: Reviewed – Some unfinished business
The D. C. Circuit published two opinions last week in cases that were argued last term. Mennonite Church USA v. DHS, No. 25-5209, which was heard in February of this year, involved a challenge to the Trump Administration’s policy of pursuing immigration-enforcement operations at houses of worship. Prior to 2025, the federal government largely maintained […]
Eric Bauza, Emmy-winning“ Looney Tunes” voice actor behind Bugs Bunny, Daffy Duck, dies at 46
Jack Quaid, “Walking Dead” star Khary Payton, “Drag Race” queen Nina West, and more paid tribute to Bauza after his death.
Stifel cuts Flutter Entertainment stock price target on Brazil exit
Stifel cuts Flutter Entertainment stock price target on Brazil exit
Britain Politics
Britain's Secretary of State for Housing, Communities and Local Government Angela Rayner speaks during a "Rough Sleeping Summit" hosted by Britain's Prime Minister Andy Burnham at Downing Street in central
Britain Politics
Britain's Prime Minister Andy Burnham speaks as he hosts a "Rough Sleeping Summit" in Downing Street in central London, Monday, Oct. 26, 2026. (Carlos Jasso/Pool Photo via AP)
BRITAIN-POLITICS
Britain's Prime Minister Andy Burnham speaks as he hosts a "Rough Sleeping Summit" in Downing Street in central London, Monday, Oct. 26, 2026. (Carlos Jasso/Pool Photo via AP)
Slotland Entertainment unveils Día de los Muertos Ricos! Mega Matrix slot
Festive skeletons, colossal symbols and mystery prizes bring the Mexican Day of the Dead to life this Halloween season.
Kennesaw State researcher explores virtual reality to improve student engagement in STEM
A Kennesaw State University researcher is exploring how virtual reality can help students stay focused and engaged during science and engineering laboratory activities. Supported by a $198,486 grant from the National Science Foundation (NSF), the research aims to help learners maintain attention, improve motor skill, and enhance learning in immersive virtual laboratories. Sungchul Jung, an assistant professor of gaming in KSU's College of Computing and Software Engineering, is leading the two-year project.
Poetslife Entertainment presents "What God has put Together (The Stage Play)"
Acadiana's Local News Leader -- bringing Lafayette the latest news, weather, sports and entertainment
Macquarie Upgrades Inspired Entertainment to Outperform From Neutral, Price Target is $7
Inspired Entertainment has an average rating of buy and mean price target of $11.96, according to analysts polled by FactSet. ...
Manuel Neuer’s Bayern Munich return is still uncertain
FC Bayern is without its captain and a slew of players for the knockout fixture on Wednesday.
Modi Rosenfeld, Jackie Goldschneider to headline Jewish entertainment panel
JOIN Israel will bring together Jewish entertainment professionals on Nov. 12 to discuss identity, representation and stereotypes while raising funds for elderly Israelis in need.
Sony backed Soneium plans native token as it expands into entertainment IP
Sony backed Soneium announces plans for a native token alongside new entertainment IP investment products, K-pop royalties and blockchain licensing tools.
Israel's tech scene warms to crypto payments
From blockchain expertise to evolving regulations, Israel’s tech ecosystem is helping normalize crypto payments, including for online poker and digital entertainment.
Susquehanna lowers Madison Square Garden Entertainment price target on venue outlook
Susquehanna lowers Madison Square Garden Entertainment price target on venue outlook
Exclusive-US Political Candidates Tailor Messages for AI Models Used by Voters
By Mike Stone WASHINGTON, Oct 26 (Reuters) - US political candidates have been engineering their campaign messages to appeal to the AI chatbots that more voters have been using to answer questions about issues, and documents seen by Reuters have revealed some of their strategies. One Powerpoint ...
Health reports - The Daily Reporter
Hancock County Health Department inspects restaurants and public food establishments four times annually. The following inspections are based on information obtained from Retail Food Inspection reports and are routine inspections, unless otherwise noted. “R” denotes violations repeated from a previous inspection.
Live Nation Entertainment (LYV) Stock Trades Near Fair Value Following Its 121% Run
Live Nation Entertainment has rewarded long term holders, and the stock now trades around US$173.44, which puts its cash generation in sharp focus. With that kind of share price level, the question is whether the current market value can be backed up by the cash flows the business is expected to produce. Over the past 3 years the stock has returned 120.7%, so a lot of future cash flow strength is already being reflected in the price. The company leans heavily on converting concert promotion...
Singapore Airlines upgrades in-flight entertainment with next-gen KrisWorld
Singapore Airlines (SIA) is enhancing its in-flight entertainment experience with next-generation KrisWorld and high-speed connectivity, giving customers more c...
SML Center hosts production of Zombie Prom for the spooky season
As the Smith Mountain Lake Center is preparing to create a permanent home at Westlake Cinema, the theater has already become a well-used space for live performances with the newest
Wieden+Kennedy launches entertainment division to make movies and shows—with and without brands
W+K Entertainment will develop original projects, starting with a Bad Bunny film, and help clients break into Hollywood.
Oklahoma reports one of the nation’s lowest Medicaid payment error rates
The state Medicaid agency said in a press release that it is working to maintain this number with new fraud-prevention tools.
Yoonha Sues C9 Japanese yen Entertainment Over Unpaid Settlements
Yoonha Sues C9 Japanese yen Entertainment Over Unpaid Settlements Singer Terminates 14-Year Contract After Legal Dispute; Agency Awaits Court Ruling
Form 4 AMC Entertainment Holdings Inc: Carla C. Chavarria (SVP CHIEF HR OFFICER) For: 24 September
Form 4 AMC Entertainment Holdings Inc: Carla C. Chavarria (SVP CHIEF HR OFFICER) For: 24 September
Singer Chris Brown to be sentenced over bottle attack at a London nightclub
Grammy-winning singer Chris Brown is to be sentenced Monday over brawling at a London nightclub in 2003.
Singer Chris Brown to be sentenced over bottle attack at a London nightclub
Grammy-winning singer Chris Brown is to be sentenced Monday over brawling at a London nightclub in 2003 | WWL
Singer Chris Brown to be sentenced over bottle attack at a London nightclub
Grammy-winning singer Chris Brown is to be sentenced Monday over brawling at a London nightclub in 2003 | K-DAWN
2026 FLIBS Nightlife Strategy: High-Powered Networking to Uninhibited After-Hours Entertainment in Fort
OutboardListings.com explores corporate networking, waterfront social experiences and Fort Lauderdale nightlife during FLIBS 2026.
Psychology says children who carry the same toy from room to room may be seeking more than entertainment
it offers familiarity, comfort and a sense of security as they navigate an unfamiliar or overwhelming world.
Sleep in total darkness to maintain heart health, researchers say
WASHINGTON — Many a pop song has nudged us to turn the lights down low, but for cardiovascular health, the better choice is to keep them off entirely it seems,
Younha ends C9 Entertainment contract over unpaid earnings
Youngha's exclusive contract with C9 Entertainment was terminated on Sept. 14. The singer has also filed a lawsuit to recover her unpaid earnings and intends to resolve the remaining issues through legal proceedings.
Derrick Harriott shaped and preserved our music
Minister of Culture, Gender, Entertainment and Sport Olivia Grange has said that, with the death of Derrick Clifton Harriott, Jamaica, sadly, has lost another of the icons who helped to shape the trajectory and reach of the country’s musical genres. Derrick Harriott was a producer, singer, and record distributor who contributed to the development of the ska, rocksteady and reggae genres. He died Saturday morning. He was 87 years old.
‘End the blame game’ — Healthcare finance leaders launch a new affordability pledge
Finger-pointing is not stopping the erosion of financial sustainability of U.S. healthcare, according to the Healthcare Financial Management Association.
How to Manage Symptoms of Heart Failure
(Feature Impact) Americans are facing a growing health challenge, with 1 in 4 adults at risk of heart failure, according to the Heart Failure Society of America. Additionally, approximately 6.7 million U.S. adults who are 20 years old or older are currently living with heart failure, and that number is projected to reach 8.7 million by 2030. googletag.cmd.push(function() { googletag.display('JGFI_Article_300x250'); }); Managing heart failure is a significant expense to the U.S. healthcare system, costing the nation approximately $40 billion in 2020 and expected to increase to approximately $142 billion a year by 2050.If you (or a loved one) are living with the condition, consider these tips to help manage it.Adhere to the Treatment and Follow-Up PlanOngoing outpatient care is important when managing heart failure. Understand the treatment plan provided by your healthcare team, make diet and lifestyle changes, take medications as directed and keep recommended follow-up appointments.Pay attention to changes in symptoms and communicate with your healthcare provider if treatment does not seem to be working as expected. If their conditions are left unmanaged, patients can experience a range of heart-failure-related symptoms such as shortness of breath, fatigue, buildup of fluid and more.Understand Challenges with Diuretic TreatmentDiuretics help the body remove excess fluid and are commonly used to treat swelling, or edema, associated with heart failure. Your provider may try different diuretics, sometimes referred to as “water pills,” to manage your heart failure symptoms. However, intravenous (IV) diuretic therapy may be required for some patients if symptoms continue.Ask About Treatment Options Before IV Care Is NeededFor some adults, a healthcare provider may consider recommending an at-home, non-oral diuretic option prior to escalating to IV therapy.For example, ENBUMYST™ (bumetanide nasal spray) is a prescription diuretic used in adults to treat edema associated with congestive heart failure. It’s administered as a nasal spray for short-term use to manage excess fluid with the goal of transitioning to oral diuretic therapy when appropriate.Talk with your healthcare provider to learn more and visit enbumyst.com. Read the full Prescribing Information and Patient Information.Photo courtesy of Shutterstock googletag.cmd.push(function() { googletag.display('JGFI_Article2_300x250'); }); Important Safety InformationWhat is ENBUMYST?ENBUMYST is a prescription medicine used in adults to treat swelling caused by excess fluid in the body (edema) from congestive heart failure, liver disease, and kidney disease.What is the most important information I should know about ENBUMYST?ENBUMYST is a diuretic that helps your body remove fluid. Losing too much fluid can cause dehydration, low blood volume, and increase the risk of blood clots. Blood abnormalities may include decreased salts (electrolytes), and increased nitrogen, glucose and uric acid. The risk of these abnormalities is higher in elderly people, those using higher doses, or those who do not get enough electrolytes by mouth.You should not use ENBUMYST if you have severe electrolyte loss. Tell your healthcare provider if you experience unusual thirst; dizziness or lightheadedness; weakness or tiredness; fast heart rate; dry mouth or tongue; sudden pain; redness or swelling in your joints; pain, swelling, redness, or warmth in your leg; shortness of breath or fast breathing; high blood sugar; dark urine; pale, tight, cool or clammy skin; muscle cramps; confusion.Do not use ENBUMYST if you have low or no urine production or are allergic to bumetanide or to any of the ingredients in ENBUMYST.Before using ENBUMYST, tell your healthcare provider if you have low electrolytes, are on a low-salt diet, have diarrhea, diabetes, nasal problems such as a runny or stuffy nose or polyps, a history of nasal injury or surgery, are or plan to become pregnant, are or plan to breastfeed.Tell your healthcare provider about all the medicines you take, including prescriptions, over-the-counter medicines, vitamins, and herbal supplements.ENBUMYST may cause serious side effects, such as worsening kidney function and ringing in the ears or hearing loss.The most common side effects of ENBUMYST include dehydration, headache, muscle cramps, dizziness, low blood pressure, nausea, and abnormal brain functioning with certain liver problems.These are not all the possible side effects of ENBUMYST. Talk to your healthcare provider for more information.Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.US-ENBU-2600110 googletag.cmd.push(function() { googletag.display('JGFI_Article3_300x250'); });
Cardiologists reveal the healthiest drinks for your heart and 2 to avoid
Certain beverages add sugar, chemicals and stimulants. The liquid calories provide less satiety than food, leading to overindulgence and weight gain.
Kane primed to pip Yamal, Mbappe to Ballon d'Or glory
England captain Harry Kane is the favourite to win a wide open race to be crowned Ballon d'Or winner at a glitzy London ceremony on Monday, with Lamine Yamal and Kylian Mbappe also in the running to be named the world's best footballer.- 'I deserve it' - Yamal finished second to Paris Saint-Germain's Ousmane Dembele last year and the 19-year-old Barcelona superstar seems destined to be a Ballon d'Or winner one day.
What to Stream: ‘Minions & Monsters,’ Matthew Perry, Daddy Yankee and ‘The Gilded Age’
A docuseries about Matthew Perry and the latest “Minions” movie are some of the new television, films, music and games headed to a device near you. Also among the streaming offerings worth your time this week, as selected by The Associated Press’ entertainment journalists: Daddy Yankee's new album, the fourth season of “The Gilded Age”
Invest Newark drives business growth across the city
Invest Newark is helping drive business growth, retail development and job creation as New Jersey’s largest city attracts new investment.
Earnings to watch: Caesars Entertainment (CZR) reports Q3 results tomorrow
Hotel and casino entertainment company Caesars Entertainment (NASDAQ:CZR) will be reporting earnings this Tuesday after market close. Here’s what to expect. ...
Earnings to watch: Caesars Entertainment (CZR) reports Q3 results tomorrow
Hotel and casino entertainment company Caesars Entertainment NASDAQ:CZRwill be reporting earnings this Tuesday after market close. Here’s what to expect.Caesars Entertainment beat analysts’ revenue expectations last quarter, reporting revenues of $2.99 billion, up 3% year on year. It was a softer q…
Yoonha Leaves C9 Entertainment After 14-Year Unpaid Settlement Dispute
Yoonha Leaves C9 Entertainment After 14-Year Unpaid Settlement Dispute Singer Files Lawsuit Over Unpaid Funds, Continues Music Career Independently
Dominant Doncic scores 52 as Lakers beat Jazz
Luka Doncic scored a monster 52 points as the Los Angeles Lakers maintained their perfect start to life after LeBron James with a 132-123 defeat of the Utah Jazz.From there Doncic and Reaves were relentless, outscoring the entire Jazz offense in the final quarter between them, as the new-look Lakers moved to a perfect 3-0 start.
Helen Mirren bags Legend of Entertainment Award at Savannah Film Festival
Helen Mirren has been honoured as a Legend of Entertainment.
Supercomputer reveals first two billion years of ‘cosmic web’
The Center for Astrophysics’s simulation offers the most detailed look yet at the infancy of the universe after the Big Bang
6 stellar images of the early universe
The most detailed simulation of our universe’s first 2 billion years to date.
Preparing for what’s next: Nursing insights on Future Ready Healthcare
New 2026 survey findings reveal how nurses view workforce sustainability, AI adoption, and patient communication, offering practical insights into what it takes to build a future-ready healthcare organization.
Panera closes in Dillon, Underground Snowboards gets new owners and more business news
Panera Bread has closed its Dillon location less than four years after opening, adding to a growing list of national restaurant chains that have shuttered businesses in the area. The establishment at 257 Dillon Ridge...
50 Cent Trolls Rick Ross After His Son's Alleged Attack
The rapper and entertainment mogul joked that he plans to bail out the suspect who allegedly assaulted Ross' son, William Roberts III.
Dunwoody to discuss adding two entertainment districts
The Dunwoody City Council will discuss adding two new entertainment districts – Georgetown and Jett Ferry – at its meeting on Monday, Oct. 26.
Shia LaBeouf waged one-sided feud with Hilary Duff, says “Even Stevens” costar
Duff’s own Disney Channel series, “Lizzie McGuire,” was one of the Disney Channel’s defining hits of the 2000s.
Orlando Magic's Sean Sweeney Message to Paolo Banchero After Injury
As a grueling road trip looms, assistant coach Sean Sweeney challenges his squad to maintain their identity and intensity while navigating Paolo Banchero’s absence against elite competition.
Missile makers see multi-year deals as politics-proof
Executives at the military’s biggest suppliers say the Pentagon’s new multi-year munitions deals are the surest way to navigate an uncertain funding climate.
French and Italian Retailers Tally Losses Ahead of Holiday Season
Retailers in France and Italy face financial losses and security concerns as protests disrupt business ahead of the holiday shopping season.
Primark's Business Doesn't Make Sense
In a world where fast fashion giants like Shein, Zara, and H&M drop thousands of new styles every day — and rake in billions through e-commerce — Primark is doing the unthinkable: thriving with zero online shopping. So what gives?*Want to Know the 5 Trends Changing Modern Retail? Find Out Here:* 🔗 https://clickhubspot.com/d13ac2In this video, we take you inside Primark’s weirdly brilliant business model — a model that’s stuck in the past on purpose. From warehouse optimization and floor-ready freight shipments to why the pandemic didn’t push them online, we unpack how this low-cost retail giant has managed to defy digital norms… and make it work.This isn’t just about one brand. It’s a story about modern retail expectations — and what it actually takes to meet (or reject) them.Subscribe to The Hustle:🔗 https://clickhubspot.com/vu3lGet the 5-minute newsletter keeping 2M+ innovators in the loop🔗 https://clickhubspot.com/3klnAbout HubSpot: HubSpot is a customer platform that provides education, software, and support to help businesses grow better. The platform includes marketing, sales, service, commerce, operations, and website management products that start free and scale to meet our customers’ needs at any stage of growth. Today, thousands of customers around the world use HubSpot’s powerful and easy-to-use tools and apps to attract, engage, and delight customers.#TheHustle #HubSpot
Big Las Vegas show closures mark a transitional time for Strip entertainment
The culture of Las Vegas is inextricably linked to the artists and technicians behind the Strip’s vibrant live entertainment industry, so any time a show closes
Editorial: Company mergers are causing more harm to the entertainment industry than good
Two weeks ago, Paramount officially completed its $110 billion purchase of the historic Warner Bros.
Retailers in Paris React to Protests [PHOTOS]
Retailers Assess Cost of Lost Business After Second Round of Protests
Supercurrent enables the reading of quantum information without destroying it
One of the fundamental challenges of quantum computing is obtaining information from a quantum bit, or qubit. Unlike a conventional bit, which can be read repeatedly without altering its content, direct ...
Retire Your Old Fountain: The Alternative From Home Depot Perfect For Your Small Patio
The Teamson Solar Gray Stone Wall Fountain from Home Depot is a great fountain for small patios thanks to its compact size and solar powered design.
Queen of Halloween Heidi Klum teases costume with mysterious image
“What’s my costume?,” the model asked fans alongside a strange close-up photo.
‘I love spending time with them’: Lewis Hamilton opens up about Kim Kardashian’s kids
Lewis Hamilton and Kim Kardashian have been one of the most talked-about couples in sports and entertainment this year, but the seven-time Formula 1 world champion has rarely said much about the relat...
Scientists Develop a Clever New Way To Kill Cancer Cells From the Inside
Scientists have developed an experimental strategy that exploits a chemical byproduct of cancer cells to produce anticancer drugs directly inside them. Scientists in Japan have developed an experimental method that uses a chemical produced by cancer cells to manufacture anticancer drugs directly inside them. The approach relies on carbon monoxide, a toxic gas that certain
Unpatched Tailscale SSH Flaws Could Let a Hacked Device Reach Root on Other Servers
Unpatched Tailscale SSH flaws could let attackers gain root on permitted servers from a compromised device when port forwarding is enabled.
BCM hosting special Nov. 13 show for America 250
BRISTOL — In partnership with The Crooked Road: Virginia’s Heritage Music Trail, Mountain Empire Children’s Choral Academy, and Theatre Bristol, the Birthplace of Country Music Museum is bringing together an
Scientists Discover How Excess RNA Can Disrupt the Energy Supply Inside Cells
Scientists at Texas A&M University discovered that excess RNA can interfere with the machinery cells use to produce energy, even without triggering certain immune defenses. The findings reveal an unex...
China Star Entertainment (SEHK:326) Stock Looks Richly Priced As Its 8.6x Run Continues
China Star Entertainment has logged very strong multi year share gains, so the key issue now is whether the current price can be supported by the value of assets on its balance sheet. For anyone looking at the stock today, the immediate question is how that share price lines up against its book value. Over the past 3 years the stock has returned about 8.6x. This puts a lot of weight on whether the underlying equity in the business justifies this kind of move when you compare it with the...
Business People: Evereve names industry vet Sarah Clary to advise on creative
RETAIL Evereve, an Edina-based women’s fashion retailer, announced it has named Sarah Clary as advisory chief creative officer. Clary previously has led creative direction campaigns and brand strategy for Hill House Home, Veronica…
Is having urine the color of Mountain Dew normal?
A Trump administration doctor says neon yellow urine is normal because of diets consisting entirely of meat and fermented foods. Here’s what experts say
"It never was entertainment to us, ever. It was always something with a lot more importance and meaning." U2 reveal the unbroken promise that they made to one another as schoolboys in Ireland 50 years ago
"Music is not a matter of life and death, it’s something much more serious than that"
Packers Lose Defensive Captain Just Before Massive Showdown With Lions
Green Bay Packers defensive captain Zaire Franklin has been ruled out against the Detroit Lions, leaving Green Bay without both starting linebackers.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Seattle Mariners Rumors: Zach Neto Gaining Traction as Possible Target
The M's certainly have a need for what Neto can provide.
Three Days Grace in San Antonio: What to know
The Canadian rockers are bringing their Alienation Tour to town. Here are the details on tickets, parking and more.
Campbell County health and food inspections (10/16/26–10/22/26)
GILLETTE, Wyo. — The Consumer Health Services Division of the Wyoming Department of Agriculture conducts inspections of retail food establishments throughout Wyoming (where there is not a local health department that does inspections) to help ensure safety of Wyoming residents. Campbell County establishments are inspected at least once a year by the WDA. All of […]