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Studying human-robot interaction, CWRU researcher explores tech-enabled mental health support | CWRU Newsroom | Case Western Reserve University
Editor’s note: Jasmine Vo, the author of this story, is a student employee in the University Marketing and Communications department. She is a fourt...
Android 17 Beta 3 finally restores the single tap Wi-Fi toggle
Google has decided to restore the ability to enable and disable Wi-Fi connections with a single tap of the QS toggle in Android 17 Beta 3.
In spreading itself across five cities, Stranger than Heaven might not lean as heavily on one of Like A Dragon's key strengths as I expected
Stranger than Heaven takes place across five different years and five different Japanese cities, RGG Studio have revealed.
Saros has been made easier than Returnal due to player feedback, though creative director claims its still "a very challenging game"
According to Saros' creative director, the game has been made easier thanks to player complaints around Returnal not having auto saves or multiple save slots.
New Resident Evil Requiem patch adds highly-anticipated photo mode feature
The powers that be at Capcom have released an update for Resident Evil Requiem, which along with other fixes and such also adds photo mode.
More concussions equal worse brain health 5 years after college sports
New concussion study deviates from the norm; most research in this space examines people in their 50s or 60s — decades after sport participation. Instead, this U-M study looks at college athletes in their 20s, and researchers already see the impact of concussion, which enables early intervention.
Hades 2 will release on Xbox and PlayStation really soon
The wait is over. The spectacular Hades 2 - five stars, if you ask Eurogamer, which you should - is coming to Xbox and …
"Everything in the final version will definitely 100% be human made" - But Owlcat says gen-AI is being used during The Expanse: Osiris Reborn development
"We don't use it to create any assets that will be in the game," says Owlcat, developer of Mass Effecty game The Expanse: Osiris Reborn. But where is the line?
Nintendo Switch 2 digital games to cost less than physical versions in US
Platform holder says change "simply reflects the different costs associated with producing and distributing each format"
PhysioNet as a global platform for biomedical research
Nature Health - Twenty-five years after its first public repository was established, the PhysioNet resource for biomedical and clinical data has enabled tens of thousands of research papers....
Crimson Desert studio Pearl Abyss's share prices stabilize as sales top 3 million
Crimson Desert developer Pearl Abyss has seen its share price stabilize after confirming the new action-adventure game …
Fortnite developers say there will be a huge impact on development "for the rest of the year and likely beyond" following mass layoffs
Fortnite developers are still in shock following over 1,000 colleagues being laid off by Epic Games, and the game's immediate future might look dark.
Tomodachi Life: Living the Dream's "Welcome Version" demo is available now, and you can transfer your saves to the full game
Tomodachi Life: Living the Dream is almost here, and an eShop demo with save data transfer is now available for Nintendo Switch consoles.
NSF initiative aims to make every American worker, business and community AI-ready
The U.S. National Science Foundation announced a new funding opportunity as part of an effort to enable all Americans to understand, apply and create with artificial intelligence. The NSF TechAccess…
Pokémon Champions is releasing on Nintendo Switch consoles in early April, but its "free-to-start" package raises some questions about its pricing model
Pokémon Champions is finally arriving in April to Nintendo Switch consoles, but its "free-to-start" model seems limiting and confusing.
PlayStation Plus Essential headliner game for April leaks
One of the games expected to arrive along with April 2026's PS Plus Essential lineup has leaked ahead of schedule.
Crimson Desert's Pearl Abyss regains investor confidence as it continues to move beyond launch day woes
After a rocky start, Pearl Abyss and Crimson Desert are regaining some lost confidence from investors.
Sony closes first-party studio Dark Outlaw Games
Developer was founded by industry veteran Jason Blundell in March 2025
Crimson Desert sells another 1m, as Pearl Abyss pledges more fixes to address launch day struggles
Crimson Desert has sold another 1m copies since Friday.
Epic Games lays off over 1,000 employees following "downturn in Fortnite engagement"
CEO Tim Sweeney says cuts are necessary to "keep the company funded" and to put it "in a more stable place"
High on Life 2's Switch 2 release delayed "to better meet not only our high standards for gaming, but yours as well"
High on Life 2, the sequel to the crude and comedic FPS from Squanch Games, has had its Switch 2 release delayed by a couple of months.
Optical Vortex Phase Masks for the Detection of Habitable Worlds
A team of NASA researchers is developing new types of optical masks that could help enable the many orders of magnitude of starlight suppression needed for future space observatories to pick out very faint habitable exoplanets from the far brighter glare of their stellar hosts.
Switch 2 demand appears to be flagging as Nintendo reportedly lowers production
Nintendo's Switch 2 got off to a roaring start but demand has started to sag, particularly in the US. Where are the big games to reverse this?
Nintendo reportedly adjusting Switch 2 production after weak holiday sales
Sources say lower production volume is expected to continue in April
Mojang partners with Merlin Entertainments for the world's first Minecraft theme park, Minecraft World
Mojang has partnered with Merlin Entertainments to build the world's first Minecraft theme park in the UK.
Microsoft-backed startup raises $40 million for advanced chipmaking equipment tech
Lace, a Norway-headquartered chipmaking equipment startup which is backed by Microsoft, has raised $40 million in funding to further develop a technology that could enable significant advances in semiconductor design and manufacturing, the company said on Monday.
Microsoft-backed startup raises $40 million for advanced chipmaking equipment tech
Lace, a Norway-headquartered chipmaking equipment startup which is backed by Microsoft, has raised $40 million in funding to further develop a technology that could enable significant advances in semiconductor design and manufacturing, the company said on Monday. To make cutting-edge chips, manufacturers such as Taiwan Semiconductor Manufacturing Co and Intel employ a process called lithography that uses light to draw complex circuits that form the foundation of advanced artificial intelligence chips. Manufacturers use light-based lithography systems made by the Dutch company ASML - which dominates the market - as they race to shrink chip components and squeeze in more features to boost the computing horsepower on a limited area of silicon.
Microsoft announces Xbox Partner Preview for this week, with Ryu Ga Gotoku's Stranger Than Heaven finally making a showing
Microsoft has announced its next Xbox Partner Preview showcase will take place later this week, focused on third-party games from the likes of Sega and GSC.
Today's hefty Crimson Desert patch includes "beginning of improvements" to keyboard and mouse controls, plus much more
Pearl Abyss has detailed a rather chunky patch for Crimson Desert, after its launch last week was marred by multiple issues and AI controversies.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Crimson Desert admits it used generative AI for "early-stage iteration" and apologises AI images were not replaced before release
Crimson Desert developer Pearl Abyss has responded to claims its latest game used AI to generate images, admitting "2D …
Capcom celebrates Resident Evil's 30th anniversary by promising "even more wonderful experiences" are coming, but doesn't confirm when
Resident Evil series executive producer, Jun Takeuchi, has written to Resident Evil players across the world, thanking …
Illinois State, Wake Forest battle for NIT quarterfinal spot
Another prolific scoring performance by Juke Harris allowed Wake Forest to keep its season alive and the best game of Landon Wolf's career enabled Illinois State to continue playing.
Surprise! Minecraft Dungeons 2 is coming later this year
Surprise! Minecraft Dungeons 2 is coming to PC via Xbox and Steam, PS5, Nintendo Switch and Switch 2, and Xbox Series a…
iOS 26.4 will automatically turn on strict security feature for all iPhones
iOS 26.4 is the next big iPhone release, and Apple plans to enable a key security feature by default in the update: Stolen Device Protection.
More Subnautica 2 legal trouble brewing amid claims Krafton "intentionally leaked" May release without consulting reinstated CEO
Lawyers for Subnautica 2 studio's newly reinstated CEO are reportedly pushing for Krafton to be found in contempt of court after it "leaked" a May release.
Crimson Desert developers "doing our utmost" to respond to its various launch issues, as game still passes huge one-day sales milestone
Crimson Desert - the ambitious single player RPG spin-off from Pearl Abyss - has sold through 2m copies following its release.
Unknown Worlds co-founders' lawyers accuse Krafton of "intentionally leaking" Subnautica 2 release date
"Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community," say lawyers
After weeks of hype, Crimson Desert debuts to high player counts but "Mixed" Steam reviews, citing "disjointed graphics", lovable cats, "awful" UI and more
Pearl Abyss' single player RPG spin-off Crimson Desert released last night, and has had a rocky debut.
Aditya Kaddu
My goal is that my career path always enables me to create real, positive impact on others.
"I genuinely thought my controller wasn't working" - Crimson Desert players are getting so annoyed with its clunky controls they're asking for launch day refunds
Crimson Desert is out, and players are already having issues with the game's controls.
How Pauline Hanson’s One Nation is changing politics: Full Story newsroom edition
Guardian Australia’s Josephine Tovey speaks with Mike Ticher and Sarah Martin about why the electorate is flocking to Pauline Hanson, One Nation and the rightwing political movement, and what major parties can do to win voters back
Ubisoft announces layoffs and the cease of game development at Red Storm Entertainment
The studio will remain open, but 105 people are being laid off as part of Ubisoft's cost reduction programme
Valve has thrown a curveball at Counter Strike 2 with a massive reloading change, forcing players to shake off old habits
Valve has added a bold change to reloading in Counter Strike 2, which is shaking up old habits for players.
Nextdoor Promotes Tony Castellanos to Executive Vice President, People as AI-Driven People Strategy Becomes Core to Business Growth
SAN FRANCISCO, March 19, 2026--Nextdoor Holdings, Inc. (NYSE: NXDR), the essential neighborhood network, today announced the promotion of Tony Castellanos to Executive Vice President, People. Castellanos will lead Nextdoor's People organization — including talent acquisition, compensation, HR business partnering, and benefits — as the company deepens its investment in AI-enabled People operations and continues to scale its workforce strategy.
Pearl Abyss shares tumble after Crimson Desert fails to meet expectations
Pearl Abyss' shares dropped by nearly 30 percent after reviews for Crimson Desert went live last night.
Pikl Pioneers a New Category of Insurance-Enabled Business Models, Earning it 20% UK Short-Term Rental Market Share
Pikl, the company pioneering insurance-enabled business models that drive revenue whilst protecting against downside risk, today announced that it has achieved 20% market share in the UK short-term rental market – the first industry in which its insurance-enabled growth solutions have been delivered. The achievement comes just two years after Pikl launched its flagship flexible cancellation solution in 2024, which allows property management companies (PMCs) to offer guests the flexible booking o
Forum on harnessing Artificial Intelligence for health equity
Register to this forumOver the past decade, artificial intelligence (AI) has significantly evolved in complexity, performance, and utility. Its integration across a wide range of industrial sectors has accelerated, with healthcare emerging as one of the most transformative sectors. In this sector, AI has enabled high-impact applications – from enhancing the speed and accuracy of disease diagnosis and supporting clinical decision-making, to strengthening public health initiatives such as disease surveillance and workforce optimization. Moreover, AI holds immense potential to empower individuals, enabling them to take greater control of their personal health and well-being. Yet the central question remains: Who benefits, who is at risk, and do these innovations close or widen health inequities? While the potential of AI-enabled applications is substantial, many countries have approached their adoption with caution. This hesitancy stems from concerns about risks and benefits, including model bias, data breaches, privacy violations, and the erosion of professional skills due to over-reliance on AI. Additional barriers include inadequate data infrastructure and a lack of robust evidence on the most effective forms and interfaces of AI to enhance service delivery and system performance. Moreover, the rapid rise of Generative AI has introduced a heightened urgency for the development of comprehensive governance and ethical frameworks. The Asian Development Bank (ADB) Health Practice Team and Digital Sector, in collaboration with the World Health Organization (WHO) Regional Office for the Western Pacific, are convening the Forum on Harnessing AI for Health Equity on 25–26 March at ADB Headquarters. Senior health officials from 16 developing member countries (DMCs), alongside leading researchers, innovators, and policymakers from across Asia and the Pacific, will engage in discussions on how AI can be governed, financed, and scaled to deliver healthier lives for all. The forum is funded through the High-Level Technology Fund with support from the Government of Japan. Objectives The two-day forum aims to:Identify high-impact, evidence-based health AI use cases suitable for resource-constrained settings and map out a pipeline for potential supportIntroduce and validate the WHO's policy guidance on minimum necessary ecosystem for countries and institutions to self-assess readiness for AI adoptionObtain initial commitment from participating stakeholders to join a pilot regional initiative focused on data/model sharing for a priority health challengeEndorse a prioritized set of actionable policy recommendations focusing on governance, regulation, and sustainable financing necessary to scale high-impact health AI use cases in resource-constrained settings Target participants The forum will convene participants from 16 ADB DMCs including Bangladesh, Bhutan, Cambodia, Cook Islands, Fiji, Indonesia, Lao People's Democratic Republic, Mongolia, Nepal, Palau, Papua New Guinea, Philippines, Sri Lanka, Thailand, Uzbekistan, and Viet Nam. In addition, health system leaders and practitioners, private sector technologists, academic experts, representatives from civil society organizations, development partners, and philanthropic institutions engaged in AI for Health from Australia, the People’s Republic of China, Japan, Malaysia, New Zealand, Singapore, and the Republic of Korea will also be invited. SessionsDay 1 (25 March)Session 1: AI Use Cases for the Care Continuum: Improving Access and QualitySession 2: Adopting a risk-based approach for AI use case prioritizationSession 3: Establishing the Minimum Ecosystem for Implementation Risk ManagementSession 4: Future-Ready Health Workforce: Building Competency for Human-AI CollaborationDay 2 (26 March)Session 5: The Political Economy of AI in Health: Understanding Stakeholder Interests and their Impact on EquitySession 6: AI and Health Financing: Supporting Fair Coverage and ProtectionSession 7: AI Regulation and Oversight: Pathways for Different RealitiesSession 8: The Way Forward – Building Alliances and Regional Partnership How to registerThe forum will be held in a hybrid format. In-person attendance is by invitation only, while livestreaming of the forum will be available to the public. To register, please complete this form on or before 24 March 2026.Event organizers / partnersAsian Development Bank (ADB)WHO Regional Office for the Western Pacific High-Level Technology Fund (HLTF)ContactAkihito WatabeHealth Specialist, SD3-HSDawatabe@adb.org Jae Kyoun KimHealth Specialist, SD3-HSDjkkim@adb.org
New Cyberpunk TCG becomes the most-funded TCG game in Kickstarter history
The resource for people who make and sell games.
Nvidia CEO says critics are "completely wrong" about DLSS 5 technology
Following concerns that upscaling feature detracts from creative expression, Jensen Huang says it "doesn't change artistic control"
Intel Precompiled Shaders Accelerate Game Load Times By Up To 3x On Arc GPUs, Now Available & Supported In 13 Games
Intel Arc GPUs can finally enable Precompiled Shaders for faster loading times that are supported in 13 games at launch.
Intel enables precompiled shader selivery on Arc B-series and Core Ultra iGPUs in new driver, up to 3x faster loading times
Intel Arc gets Graphics Shader Distribution Service, 13 games supported at launch Today, Intel has rolled out its Graphics Shader Distribution Service in
Starfield finally lands PS5 release date, along with new story DLC and Free Lanes update which - among other things - adds a Milliewhale pet
After plenty of rumours and rumblings, Bethesda has today announced that Starfield is coming to PlayStation 5.
Bethesda promises Nvidia's controversial DLSS 5 AI filters will be "totally optional" for players
Bethesda is committed to "further adjusting the lighting and final effect" of Nvidia's DLSS 5 visuals on Starfield following the controversial AI-tech's reveal.
Krafton responds to Subnautica 2 legal ruling: "we are evaluating our options as we determine our path forward"
Krafton has issued a statement in response to a legal ruling yesterday, which pushed for CEO Ted Gill to be reinstated to the Subnautica 2 studio.
Bombshell judgment demands Krafton immediately reinstate ousted CEO and return his authority over Subnautica 2
In a bombshell ruling, a court has ordered Krafton to reinstate former Unknown World CEO Ted Gill, return control of th…
The Seven Deadly Sins: Origin is a free-to-play open world anime RPG with flying pigs and minecart levels
The latest RPG from Netmarble is a splashy fantasy anime confection, all Disney towers and fluttering windmills and jaunty sailboats and transforming pigs.
Judge orders Subnautica 2 bosses be handed back control of company after Krafton found guilty of "wrongfully usurping control"
A judge has ruled in favour of the Subnautica 2 developers fired by publisher Krafton.
Judge delivers bombshell order for Krafton to reinstate fired Subnautica 2 devs and CEO, putting $250m bonus package back on the table
A judge has ruled that fired Subnautica 2 leads including the former Unknown Worlds CEO must be reinstated, with their $250m bonus package extended.
EHR fragmentation offers an opportunity to enhance care coordination and experience
Harmonizing electronic health record platforms and their legacy data tames complexity and enables easier patient access to information and greater patient trust in the healthcare system, says NewYork-Presbyterian's EHR manager.
Resident Evil Requiem crosses 6 million copies sold, becoming the fastest-selling game in the survival horror series' history
Resident Evil Requiem has already sold 6 million copies and become the fastest-selling entry in the series' history, Capcom has announced.
Warner Bros Montréal reportedly hit with staff cuts
Former employees state that roles across multiple divisions were made redundant last Friday
Bethesda drops unusual tease that it'll have Starfield news for us "next week"
Bethesda has teased that we can expect new information about Starfield "next week".
Linux Finally Catches Up to Windows with a Game-Changing Performance Feature
For years, the Linux kernel’s scheduler has been world‑class at balancing loads, yet it missed a crucial, cache‑aware instinct. In modern multi‑core systems, that gap can turn into measurable latency, especially when threads bounce between cores that don’t share the same cache. A new upstream feature, often called Cache Aware Scheduling, is now set to change that equation. A cache‑savvy scheduler arrives At the heart of any OS, the scheduler decides which thread runs where and for how long. In modern CPUs, small private caches (L1 and L2) sit beside each core, while a larger Last Level Cache (LLC, typically L3) is shared among groups of cores. When a task migrates across LLC boundaries, its warm data may vanish from the cache, forcing slower trips to main memory. Cache Aware Scheduling keeps related tasks close to their shared LLC, reducing destructive migrations. By respecting cache topology, the kernel minimizes cold‑start penalties and preserves locality that many workloads desperately need. The result is less thrashing, fewer memory stalls, and more consistent throughput. "Keep tasks close to their data, and the system will keep performance close to its peak." Why this narrows the Windows gap Windows has long leaned on topology‑aware, cache‑sensitive heuristics, especially since the Windows 10 era. That advantage helped Microsoft handle hybrid designs with P‑cores and E‑cores, plus complex cluster and NUMA layouts. With cache awareness integrated upstream, Linux brings parity to this vital dimension, without sacrificing its trademark flexibility. The Linux approach remains deeply configurable, reflecting the ecosystem’s breadth across servers, desktops, and embedded devices. It layers atop existing NUMA‑balancing and energy‑aware logic, refining placement rather than reinventing the wheel. Crucially, it aligns scheduling with the hardware’s real shape, not just with abstract CPU counts. Real‑world gains and who benefits Early tests on Intel Sapphire Rapids platforms point to gains in the 30–45% range for select workloads. Those wins appear in cache‑sensitive tasks like in‑memory analytics, high‑thread compilation, and microservices with tight working‑sets. Games and latency‑bound engines can also feel steadier frame‑times, especially when threads share hot assets. The benefits extend to AMD’s 3D V‑Cache parts, where keeping threads near enlarged cache slices prevents needless misses. Hybrid x86 designs with performance and efficiency cores further profit when cache and core roles are scheduled in concert. Even handhelds running SteamOS can squeeze more out of limited power, translating cache locality into smoother play. Key advantages include: Lower end‑to‑end latency Fewer expensive misses to RAM Better multi‑socket and NUMA behavior Improved energy efficiency More predictable QoS under mixed loads Stronger scaling on dense servers Caveats, tuning, and rollout No scheduler change is purely free, and trade‑offs still exist. Favoring locality can reduce cross‑cluster balance if limits are set too tight. Likewise, fairness and utilization must remain healthy, especially under heterogeneous, bursty workloads. Linux’s implementation is designed to be measured and tunable, not a blunt instrument. It cooperates with energy‑aware scheduling for mobile efficiency, and with NUMA‑balancers on big iron. Expect architecture‑specific refinements as vendors surface richer topology hints and cache‑sharing maps. Upstream integration has begun, with broad distribution adoption likely over the next cycles. Many users will encounter the change through standard kernel updates in 2025–2026, depending on distro cadence. Server‑class kernels may enable or tune it sooner for targeted fleets where cache locality is money in the bank. How to think about performance impact Cache Aware Scheduling amplifies gains when your workload is both CPU‑bound and cache‑sensitive. Think tight inner loops, hot code paths, and datasets that fit snugly in shared LLC. It’s less dramatic for I/O‑bound services or memory‑hungry tasks that blow past cache capacity. Still, even modest locality improvements often translate into smoother tail‑latency, which is where user experience and SLAs typically break. Developers can further help by pinning related threads, batching work, and aligning data to reduce cross‑cluster chatter. The scheduler’s new awareness works best when applications expose good hints. The bottom line By understanding and honoring cache topology, Linux removes a subtle yet costly bottleneck. The kernel’s smarter placement keeps hot data hot and work near where it belongs. That narrows a long‑standing gap with Windows, while preserving the openness and tunability Linux champions. For gamers, creators, and operators, the payoff is practical: more consistent frames, faster builds, and snappier services. For the ecosystem, it’s another step toward hardware‑savvy scheduling that turns transistor complexity into real‑world speed. And for Linux itself, it’s a timely upgrade that matches today’s silicon with tomorrow’s expectations.
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