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Business briefs: New businesses coming to NKY - Marshalls, Fruit Land, Penn Station
Staff report Marshalls to open in Cold Spring Pointe Marshalls, one of the nation’s leading off-price retailers with over 1,200 stores currently operating in 48 states, D.C., and Puerto Rico, will open at Cold Spring Pointe on April 9. Shoppers in Cold Spring will find an amazing selection of high-quality merchandise across fashion, accessories, shoes,...
Maxence Lacroix ‘dreams’ about playing at the 2026 World Cup
His first selection for the French national team has barely sunk in, yet Maxence Lacroix (25) is already looking ahead to his future with Les Bleus. With, of course, the World Cup firmly in his sights...
These U.S. States Plan to Offer iPhone's Driver's License Feature
In select U.S. states, residents can add their driver's license or state ID to the Apple Wallet app on the iPhone and Apple Watch, and then use it to display proof of identity or age at select airports and businesses, and in select apps. The feature is currently available in 13 U.S. states and Puerto Rico, and it is expected to launch in at least seven more in the future. To set up the feature, open the Wallet app and tap on the plus sign in the top-right corner.
Malik Willis briefed on Jaylen Waddle trade before it happened
Earlier this month, the Miami Dolphins shocked their fan base by trading one of the team’s most beloved and dynamic stars — wide receiver Jaylen Waddle. The former first round pick was packaged with a fourth round pick and sent to the Denver Broncos in exchange for 2026 first, third and fourth round selections. While […]
NASA Selects Intuitive Machines to Deliver Artemis Science, Tech to Moon
NASA has awarded Intuitive Machines of Houston, $180.4 million to deliver NASA-funded science and technology to the lunar surface as part of the agency’s CLPS
SAVE plan: Millions of student-loan borrowers resume payments in fall
After eliminating the SAVE student-loan repayment plan, Trump's Education Department is now advising borrowers to select a new plan and start paying.
NASA Names Scientists to Support Lunar South Pole Science
NASA has selected 10 participating scientists to help shape a science plan for astronauts to complete on the lunar surface under the Artemis program –
Eagles face early-round pressure to address two glaring needs
Two of Eagles' top draft needs must be addressed sooner in the selection meeting rather than later.
Your stereotypes about Gen Z aren’t just inaccurate. They’re hurting your business
Welcome to Fast Company Daily, our daily newsletter on LinkedIn, featuring a free article selected each day by our editors as well as a roundup of great advice on careers, hiring, innovation, and technology. Visit fastcompany.
Public health alert issued for raw beef, pork. See affected products.
A public health alert was issued for select Blackwing raw beef and pork products on March 25 because they were not federally inspected.
How to Break America’s Great Scientific Stagnation
President Trump’s selection of Jim O’Neill to head the National Science Foundation could open the next great chapter of discovery.
2025 American Association for the Advancement of Science (AAAS) Fellow
Department Chair, Professor Alexander Spokoyny has been selected as a 2025 Fellow of the American Association for the Advancement of Science (AAAS) in recognition of his distinguished contributions in main group and organometallic chemistry and academic community engagement and leadership. AAAS is the world’s largest general-scientific society and publisher of the journal Science. Spokoyny is among the 449 scientists, engineers, and innovators spanning 24 scientific disciplines who are being recognized for their scientifically and socially distinguished achievements. Four of the new fellows are UCLA faculty members. The new Fellows will be celebrated in Washington, D.C., in late May 2026. Read more about the new AAAS Fellows here. AAAS Fellows in the UCLA Department of Chemistry & Biochemistry are Professors Kendall Houk (1988), Paul Weiss (1999), Richard Kaner (2000), David Eisenberg and Todd Yeates (2001), Juli Feigon (2002), Miguel Garcia-Garibay and Steven Clarke (2007), Heather Maynard, Carla Koehler, Xiangfeng Duan and Neil Garg (2018), Paula Diaconescu and Thomas Mason (2019), Joseph Loo (2021), and Yi Tang (2022). Penny Jennings, UCLA Department of Chemistry & Biochemistry, penjen@g.ucla.edu.
Henry’s handball, last-lap drama, Stanley Cup chaos: unjust moments in sport that could have been overturned
Following the result of the AFCON final being reversed, our writers have selected incidents where similar could have happened
All-League Greyhounds in winter sports named | Healdsburg Tribune | Local News Healdsburg, California
“What’s impactful about these selections is that they are decided on by all of the peer head coaches in the girls league. Each girl is talked about; some advocated for stat by stat, others in a speech-like cadence. These girls selected are getting head nods from all these other coaches. It’s a special recognition.”
Derek Sant’Angelo named fellow of the American Association for the Adv
This highly selective honor is in recognition of the VCU professor’s career-long contributions to the field of T cell immunology.
tvOS 26.4 Adds These New Features to Your Apple TV
Apple this week released tvOS 26.4, and the software update includes a handful of new features and changes for the Apple TV. tvOS 26.4 is compatible with all Apple TV 4K and Apple TV HD models released since 2015. To update your Apple TV, open the Settings app on the device, navigate to System → Software Updates, and select Update Software. Below, we have recapped what is new in tvOS 26.4.
The Institute for Underground Science at SURF Announces 2026 Davis-Bahcall Scholars
The Institute for Underground Science at Sanford Underground Research Facility (SURF) has announced the selected the 2026 cohort of Davis-Bahcall Scholars.
Dallas Mavericks beef up staff as arena plans progress
Mavericks CEO Rick Welts has said the team prefers to have an arena and entertainment district site selected by July 1.
High school students pitch business ideas during competition at Lincoln Financial Field
The group of students was selected from over 30 submissions.
Business Titan Awarded Student Employee Scholarship
Business administration student Trisha Tran Truong was selected as the fall 2025 recipient of the Auxiliary Services Student Employee Scholarship, which recognizes a student employee who demonstrates academic dedication, leadership and a strong commitment to serving the campus community. Truong has been a member of the campus dining team since 2022, working at the on-campus […]
Seahawks Survey: What will John Schneider do with pick 32?
Trade or stick and pick? What will the Seahawks do with their first-round selection?
The 2026 Cohort Of Schmidt Science Fellows Is Announced
The 2026 cohort of Schmidt Science Fellows has been selected. The 32 fellows are recent PhDs who’ve been nominated as some of the world's leading early-career scientists.
Joe Flacco returning to Bengals: 41-year-old QB set for 19th NFL season in 2026
Flacco is coming off his first Pro Bowl selection.
Joe Flacco reportedly agrees to return to Bengals
Flacco went 1-5 in his starts with the Bengals and earned a Pro Bowl selection.
In Oklahoma, Alan Armstrong Will Fill Markwayne Mullin’s Senate Seat
Gov. Kevin Stitt selected Mr. Armstrong, a fellow Republican and an energy executive, to play a caretaker role in the seat until the next election.
12 Life Science Startups Named to SLAS Europe 2026 Innovation Showcase Program
SLAS has named the 12 companies selected to participate in its Innovation AveNEW program at the SLAS Europe 2026 Conference and Exhibition.
Brown Named College Sports Communicators Academic All-District
Guard Malea Brown of the Longwood women's basketball team has been named to the 2025-26 Academic All-District® NCAA Division I women's basketball team as selected by the College Sports Communicators, the organization announced Tuesday.
Steven Corcelli named William K. Warren Foundation Dean of the College of Science
Steven A. Corcelli, professor of chemistry and biochemistry at the University of Notre Dame, has been appointed the William K. Warren Foundation Dean of the College of Science by University President Rev. Robert A. Dowd, C.S.C., effective April 1. Corcelli, who has served as interim science dean since July, was selected through a comprehensive national search launched after his predecessor, Santiago Schnell, was appointed as Dartmouth’s provost.
Helping seniors thrive through connection
ETSU is one of three universities nationwide selected to develop senior nutrition programs.
Six Panthers selected to College Sports Communicators Basketball Academic All-District Teams
CEDAR FALLS, Iowa --- Six members of the UNI men's and women's basketball teams were recognized by College Sports Communicators (CSC) with Academic All-Distr...
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
Who experts predict 49ers will select with first-round pick in 2026 NFL Draft
Here's who writers and experts around the country believe the San Francisco 49ers will select in the first round of the 2026 NFL Draft.
Alabama High School Sports Hall of Fame inducts 12 coaches, administrators in Class of 2026
Inductees selected from slate of 60 nominees.
Mexico's Karim Lopez reportedly declares for the 2026 NBA Draft
Lopez could become the first player of Mexican descent selected in the first round.
Prisco's 2026 NFL mock draft 1.0: Four of top five picks on defensive side, Browns select QB
Teams at top of the draft opt for pass rush over offense.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Breaking down Bills’ selections in latest NFL mock drafts
According to the latest NFL mock drafts, the Bills could go wide receiver, linebacker, safety, or defensive linemen at pick 26.
Eagles Predicted to Make Perfect Selection in 2026 NFL Draft
The Philadelphia Eagles have had a nice offseason and that should only continue in the NFL Draft.
Report: Panthers agree to terms with local free-agent LB
The Panthers are reportedly signing an Anderson, S.C. native and former All-Sun Belt selection.
How the NCAA tries to ensure game integrity amid a sports betting boom and the latest point-shaving scandal
Two months before Selection Sunday, a widespread college basketball game-fixing scandal was revealed. How can the NCAA stop it from happening again?
How did these flowers evolve to survive a megadrought?
A multi-year megadrought in the Western U.S. has claimed untold populations of wild plants. Amid the conditions, some have survived. Scientists have produced a stunningly complete picture about how populations of one particular flower – the scarlet monkeyflower – made it through. In a new study published in the journal Science, a team of scientists spent decades studying and sampling select populations of scarlet monkeyflowers in California and Oregon. Through genetic sequencing, the team discovered that the populations that did best went through genetic changes in a short time period. This is known as rapid evolution. The team found that three of the populations that recovered the BEST adapted their stomata to open less, so they could conserve more water. Stomata act like a plant’s pores, managing gas exchange and water loss. This allowed the scarlet monkeyflowers to hunker down in the drought and survive. Interested in more stories about rapid evolution? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.Listen to Short Wave on Spotify and Apple Podcasts.This episode was produced by Jeffrey Pierre, Rachel Carlson and Hannah Chinn. It was edited by Christopher Intagliata and Rebecca Ramirez. Aru Nair checked the facts. The audio engineers were Becky Brown and Robert Rodriguez.
US Health Department official signals progress on selecting new CDC head
The top CDC job has been filled by acting directors since Trump fired then-director Susan Monarez last August, after she objected to Kennedy's proposed vaccine policy changes.
Ranking LeBron James's 10 most unbreakable records: All-NBA selections, playoff points and more
James is about to become the new all-time leader in games played
2026 NFL mock draft: Every team makes a pick -- even those without a first-rounder
Five teams won't be on the clock on Day 1, but we've still projected their first selection.
Intel reportedly limits first Core 200HX Plus shipments to select laptop makers
Core Ultra 200HX Plus gaming laptops arrive first on Lenovo Legion and Razer Blade systems Intel’s new Core Ultra 200HX Plus laptop processors are not
March Madness bracket picks: Cinderellas, upsets, Final Four predictions and more for the NCAA men's and women's tournaments
Foxborough Select Board unanimously approves entertainment license for FIFA World Cup
The Foxborough Select Board unanimously approved an entertainment license for the FIFA World Cup matches at Gillette Stadium.
Scientists Use AI And Simulated Natural Selection To Evolve Real-World Robots
“These are the first robots to set foot outdoors after evolving inside of a computer,” said one of the researchers.
Sara Hamideh Named 2026 NAS Frontiers of Science Fellow
SoMAs associate professor Sara Hamideh has been selected as a 2026 Frontiers of Science Fellow by the National Academy of Sciences.
From the sports desk: Let the ‘Madness’ begin
On Selection Sunday, Duke, UConn take top seeds in men’s and women’s brackets.
Thompson Scholars Program preparing future pre-health professionals for early success at UTC
The University of Tennessee at Chattanooga is offering incoming and transfer students an opportunity to strengthen their math and chemistry skills before the fall semester begins through the Thompson Scholars Program, a selective summer bridge experience designed for students pursuing professional health care careers.
UCLA was snubbed by women's NCAA tournament selection committee
The UCLA women's basketball team drew the toughest NCAA tournament regional field after getting passed over for the No. 1 overall seed.
Women's March Madness bracket 2026: Updates, NCAA Tournament schedule and dates
Here's everything to know about the 2026 women's NCAA Tournament as the bracket is unveiled on Selection Sunday.
Selection Sunday 2026: Live updates on March Madness, bracketology for men's NCAA tournament as Duke, Arizona, Michigan, Florida secure No. 1 seeds
2026 Selection Sunday Live Updates: Men's, Women's NCAA Tournament Brackets
Selection Sunday unfolds tonight, with the men's tournament bracket revealed first, followed by the women's. Follow along with us!
Women's NCAA Tournament Selection Sunday live updates: Bracket unveiled today
The countdown to women's March Madness begins on Selection Sunday. UConn, UCLA, South Carolina and Texas appear to be locks for No. 1 seeds.
Men’s March Madness Selection Sunday Live Updates: Seeds, Matchups and Analysis
March Madness is finally upon as the selection committee will name the 68 teams competing in the NCAA tournament. Follow along with SI.
Final Bracketology: CBS Sports projection sees Iowa State reclaim No. 2 seed, SMU stays in the field of 68
Here is the final CBS Sports Bracketology projection ahead of the 2026 NCAA Tournament selection show
Akheem Mesidor to Seahawks at No. 32 in CBS Sports mock draft
The Seahawks select Miami defensive lineman Akheem Mesidor with the No. 32 overall pick in CBS Sports’ latest three-round mock draft.
Men’s College Basketball Bracketology for Selection Sunday Morning 2026
The only real drama left is the Atlantic 10’s bid total and how that will affect the Cut Line picture.
How to watch Selection Sunday for the NCAA bracket release
Indiana enters Selection Sunday firmly on the wrong side of the bubble. Here’s how and when to watch the selection show.
How to watch Selection Sunday for the NCAA bracket release
Selection Sunday has arrived. Here are all the details.
2026 NCAA Tournament bracket expert picks: No. 1 seeds predicted before Selection Sunday show
Michigan has a lot on the line Sunday vs. Purdue in the Big Ten Championship
Final 68-team bracketology for 2026 Women’s NCAA Tournament
The Ivy League title was decided and the top 16 seeds have been revealed. Hours before Selection Sunday, we have a clearer picture of the field of 68.
Your Selection Sunday Viewing Guide: March 15, 2026
We have NINE more automatic bids to hand out before we get to the bracket reveals tonight!
2026 NFL mock draft: Broncos add massive defensive lineman
The Broncos select a massive defensive lineman in this 2026 NFL mock draft.
Linux Finally Catches Up to Windows with a Game-Changing Performance Feature
For years, the Linux kernel’s scheduler has been world‑class at balancing loads, yet it missed a crucial, cache‑aware instinct. In modern multi‑core systems, that gap can turn into measurable latency, especially when threads bounce between cores that don’t share the same cache. A new upstream feature, often called Cache Aware Scheduling, is now set to change that equation. A cache‑savvy scheduler arrives At the heart of any OS, the scheduler decides which thread runs where and for how long. In modern CPUs, small private caches (L1 and L2) sit beside each core, while a larger Last Level Cache (LLC, typically L3) is shared among groups of cores. When a task migrates across LLC boundaries, its warm data may vanish from the cache, forcing slower trips to main memory. Cache Aware Scheduling keeps related tasks close to their shared LLC, reducing destructive migrations. By respecting cache topology, the kernel minimizes cold‑start penalties and preserves locality that many workloads desperately need. The result is less thrashing, fewer memory stalls, and more consistent throughput. "Keep tasks close to their data, and the system will keep performance close to its peak." Why this narrows the Windows gap Windows has long leaned on topology‑aware, cache‑sensitive heuristics, especially since the Windows 10 era. That advantage helped Microsoft handle hybrid designs with P‑cores and E‑cores, plus complex cluster and NUMA layouts. With cache awareness integrated upstream, Linux brings parity to this vital dimension, without sacrificing its trademark flexibility. The Linux approach remains deeply configurable, reflecting the ecosystem’s breadth across servers, desktops, and embedded devices. It layers atop existing NUMA‑balancing and energy‑aware logic, refining placement rather than reinventing the wheel. Crucially, it aligns scheduling with the hardware’s real shape, not just with abstract CPU counts. Real‑world gains and who benefits Early tests on Intel Sapphire Rapids platforms point to gains in the 30–45% range for select workloads. Those wins appear in cache‑sensitive tasks like in‑memory analytics, high‑thread compilation, and microservices with tight working‑sets. Games and latency‑bound engines can also feel steadier frame‑times, especially when threads share hot assets. The benefits extend to AMD’s 3D V‑Cache parts, where keeping threads near enlarged cache slices prevents needless misses. Hybrid x86 designs with performance and efficiency cores further profit when cache and core roles are scheduled in concert. Even handhelds running SteamOS can squeeze more out of limited power, translating cache locality into smoother play. Key advantages include: Lower end‑to‑end latency Fewer expensive misses to RAM Better multi‑socket and NUMA behavior Improved energy efficiency More predictable QoS under mixed loads Stronger scaling on dense servers Caveats, tuning, and rollout No scheduler change is purely free, and trade‑offs still exist. Favoring locality can reduce cross‑cluster balance if limits are set too tight. Likewise, fairness and utilization must remain healthy, especially under heterogeneous, bursty workloads. Linux’s implementation is designed to be measured and tunable, not a blunt instrument. It cooperates with energy‑aware scheduling for mobile efficiency, and with NUMA‑balancers on big iron. Expect architecture‑specific refinements as vendors surface richer topology hints and cache‑sharing maps. Upstream integration has begun, with broad distribution adoption likely over the next cycles. Many users will encounter the change through standard kernel updates in 2025–2026, depending on distro cadence. Server‑class kernels may enable or tune it sooner for targeted fleets where cache locality is money in the bank. How to think about performance impact Cache Aware Scheduling amplifies gains when your workload is both CPU‑bound and cache‑sensitive. Think tight inner loops, hot code paths, and datasets that fit snugly in shared LLC. It’s less dramatic for I/O‑bound services or memory‑hungry tasks that blow past cache capacity. Still, even modest locality improvements often translate into smoother tail‑latency, which is where user experience and SLAs typically break. Developers can further help by pinning related threads, batching work, and aligning data to reduce cross‑cluster chatter. The scheduler’s new awareness works best when applications expose good hints. The bottom line By understanding and honoring cache topology, Linux removes a subtle yet costly bottleneck. The kernel’s smarter placement keeps hot data hot and work near where it belongs. That narrows a long‑standing gap with Windows, while preserving the openness and tunability Linux champions. For gamers, creators, and operators, the payoff is practical: more consistent frames, faster builds, and snappier services. For the ecosystem, it’s another step toward hardware‑savvy scheduling that turns transistor complexity into real‑world speed. And for Linux itself, it’s a timely upgrade that matches today’s silicon with tomorrow’s expectations.
A nasty Windows 11 bug is causing the C drive to become inaccessible in select devices, says Microsoft
There is a custom fix, but it's probably best to wait.
Apple Kicks Off 50th Anniversary With Surprise Alicia Keys Concert in New York
Apple mysteriously shut down its Grand Central Terminal store in New York City today, and it turns out it was for an impromptu Alicia Keys concert to celebrate Apple's upcoming 50th anniversary. Apple quietly invited select YouTubers and members of the media (including MacRumors) to the store location, but kept the performer secret until Alicia Keys took the stage.
Derek Schaeffer selected as a 2026 Frontiers of Science Fellow
The assistant professor was one of 80 early-career U.S. researchers honored by the National Academy of Sciences program.
Sabrina Ramonov Launches “Women Build AI,” a Selective Free Community for Founders and Small Business Builders
Blotato founder Sabrina Ramonov launches Women Build AI, a selective free community focused on practical AI
Samsung lists apps that work directly via satellite on Galaxy phones
Samsung has started listing apps that work directly via a satellite connection on compatible Galaxy phones in select countries and markets.
March Madness 2026 live updates: Bracketology, bubble watch, predictions for NCAA Tournament field of 68
With Selection Sunday just a few days away, here's the latest as the NCAA Tournament's field of 68 is built
Bracketology: Race for NCAA Tournament's top seeds enters final stretch before Selection Sunday
Duke, Arizona and UConn begin conference tournament play with the NCAA Tournament's No. 1 seeds still at stake. Here's how the bracket's top line could unfold before Selection Sunday.
Horizon League, City of Noblesville, Hamilton County Sports Authority and REV Entertainment Announce The Arena at Innovation Mile as the Future Site of Basketball Championships
NOBLESVILLE, IND. (March 12, 2026) – The Horizon League Council has selected The Arena at Innovation Mile (AIM) in Noblesville, Ind. as host of the second rounds, semifinals and championships of the 2027-2031 Horizon League Men’s and Women’s Basketball Championships, the League office announced in conjunction with its new partners on Thursday. ?The 2027 Championships will tip off on campuses with teams advancing to AIM to compete in the final three rounds: Second Round (Sunday, March 7) Semifinals (Monday, March 8) Championships (Tuesday, March 9)
Rice Business launches Moody Business Scholars Program to accelerate undergraduate career pathways
Rice’s Virani Undergraduate School of Business is introducing the Moody Business Scholars Program, a highly selective, cohort-based undergraduate experience designed to prepare high-achieving business students for high-profile careers in competitive industries.
'Rangers can sell Fernandez for £40m'
Scotland caps nearing comebacks, St Mirren select stand-in boss for Rangers' visit and Hibs injuries latest.
Horizon League, City of Noblesville, Hamilton County Sports Authority and REV Entertainment Announce The Arena at Innovation Mile as the Future Site of Basketball Championships
NOBLESVILLE, IND. (March 12, 2026) – The Horizon League Council has selected The Arena at Innovation Mile (AIM) in Noblesville, Ind. as host of the second rounds, semifinals and championships of the 2027-2031 Horizon League Men's and Women's Basketball Championships, the League office announced in conjunction with its new partners on Thursday.
Acuff Named 1st Team All-America by The Sporting News
Arkansas freshman Darius Acuff was selected first team All-America by The Sporting News, it was announced today.
USA TODAY Sports Network 2026 All-ACC men's basketball awards, player of the year
Cameron Boozer and Duke basketball took home major honors in the USA TODAY Sports Network's All-ACC awards. Check out the full selections.
USA TODAY Sports Network 2026 All-ACC men's basketball awards, player of the year
Cameron Boozer and Duke basketball took home major honors in the USA TODAY Sports Network's All-ACC awards. Check out the full selections.
Broncos' finalized order of picks in 2026 NFL draft
The league has announced the finalized order of picks in the 2026 NFL draft. The Broncos currently hold nine selections.
Trotter's Trends: Cardiac Kemba, reincarnated; limping into Selection Sunday and the rim-defense script
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AJ Rose Carpets & Flooring Selected for TD Small Business Takeover at TD Garden During March 10 Bruins Game
Four Decades of Local Service Meets one of Boston's Biggest Stages
Trump 'disappointed' by the selection of Mojtaba Khamenei in Iran
The U.S. sanctioned Mojtaba Khamenei for representing his father to advance his \
LSA needs to scrap its natural science requirement
To meet LSA’s natural science requirement, most students select two of these courses and exert the minimum effort needed to acquire an A — which could be a problem because most feel they’re learning next to nothing. LSA’s natural science course requirement forces students to take classes they lack interest in and fails to achieve any meaningful development of natural science skills or knowledge. It should be scrapped.
Trade Your Smartphone for an ’80s-Style Digital Watch
These retro selections may have some new tricks, but they keep things comparatively simple.
Variety and Gold House to Spotlight Asian Pacific Creatives in Entertainment With Third Annual 8 Up Next List
Variety will publish its third 8 Asian Pacifics Up Next in Entertainment list on May 6. Once again, Variety will work with a team at Gold House to select the eight Asian Pacifics making an impact acro...
Electronic Arts is laying off workers at the Battlefield 6 studios
"We’ve made select changes within our Battlefield organization to better align our teams around what matters most to our community"
USA TODAY Sports Network 2026 All-SEC men's basketball awards, player of the year
Darius Acuff Jr. and the Florida Gators took home major honors in the USA TODAY Sports Network's All-SEC awards. Check out the full selections.
Andexler Honored for Commitment to Science Advocacy
Northern Michigan University master's candidate Noah Andexler is one of 20 graduate students nationwide selected to receive the Ecological Society of America's (ESA) 2026 Katherine S. McCarter Graduate Student Policy Award for their demonstrated commitment to science advocacy. This prestigious program is designed to bridge the gap between rigorous ecological research and impactful environmental policy.
Spectrum Business Scores Connectivity Hat Trick With Tampa Bay Lightning
Tampa Bay Lightning ownership team Vinik Sports Group has selected Spectrum Business for connectivity solutions that create an exceptional guest experience.
Marubeni Chosen for the 2026 Health & Productivity Stock Selection (Fifth Selection over Four Consecutive Years), and Certified as a “White 500” Company for the Ninth Consecutive Year
Marubeni Corporation
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2026 iMac Rumored to Come in New Colors
Apple's upcoming 2026 iMac will be available in a refreshed selection of colors, Bloomberg's Mark Gurman reports. In today's "Power On" newsletter, Gurman said that the next iMac will feature a new selection of colors. This could be the first true refresh of the device's color options in five years. The iMac redesign introduced in 2021 uses a distinctive two-tone color design, where the color appears differently on the front and back of the machine.
March Madness bubble watch: Stock up, down heading into conference tournaments
With Selection Sunday a week away, teams on the bubble are running out of time to impress the NCAA tournament selection committee.
Spring Training: Honor Health opens lot for fans
For some Spring Training fans, their parking selection could be a game changer for some Valley students, as Honor Health opens its lot, in the name of a good cause. FOX 10's Megan Spector has more.
14 Leaders Selected for Third Cohort of Nonprofit News Business Certificate at the Newmark J-School - Newmark J-School
The Nonprofit News Business Certificate welcomes its third cohort of 14 leaders.
Houston Texans legend J.J. Watt selected for Houston Sports Hall of Fame Class of 2026
The former Texans superstar was chosen as the first member of the Houston Sports Hall of Fame Class of 2026.