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Anger Over Health Costs Clouds Midterms
Amid a campaign already focusing on affordability, anxious voters are unlikely to be assuaged by headlines about healthcare costs rising even more next year. And a lawsuit that could cut off access nationwide to the abortion pill mifepristone gets a hearing in federal court. Joanne Kenen of the Johns Hopkins Bloomberg School of Public Health and Politico Magazine, Sandhya Raman of Bloomberg Law, and Amanda Seitz of KFF Health News join KFF Health News’ Julie Rovner to discuss these stories and more. Also this week, Rovner also interviews Lauren Sausser, who wrote the latest KFF Health News “Bill of the Month.”
FSU industry leaders explore big picture of collegiate athletics at annual NIL summit
Florida State University brought together campus leaders Friday for a wide-ranging discussion on the future of Name, Image, and Likeness at the second
ESPN expanding Women’s Sports Sundays this fall
When Sunday Night Baseball moved from ESPN to NBC this year, it left a gap in ESPN’s lineup that had provided consistent Sunday-night programming for much of the year. In its place, the worldwide leader in sports unveiled a theme of Women’s Sports Sundays. And even though the calendar is shifting from summer to fall,…
Thousands seek support at Duke caregiver event as NC population ages
The Duke Health Caregiver Community Event helps connect caregivers to resources near them as the need for caregivers grows statewide. Attendees can speak with trained professionals to receive guidance on how to best navigate the many challenges that come with caregiving.
For these Midwest farmers, regenerative agriculture is about more than soil health. It's spiritual
The towering maple trees and native hazelnut bushes on Salvatierra Farms break up the surrounding corn and soybean fields that sprawl across southern Minnesota.
Apple Watch Series 12 Has Smaller Screens and Bigger Cases
The Apple Watch Series 12 pairs a smaller display with a wider case than Series 10 and Series 11, even though the pixel resolution hasn't changed, according to Apple's own tech specs. For the 46mm Series 12, Apple's tech specs page lists the display area at 1,196 sq mm, down 2% from 1,220 sq mm on Series 10 and Series 11. The 42mm size shows a similar 1.9% drop, from 989 sq mm to 970 sq mm.
Greater Jamaica Development Corp. opens applications for citywide minority- and women-owned business accelerator
A citywide entrepreneurial growth accelerator for established minority- and women-owned businesses has launched applications for its exclusive 12-week
Canada's major General Contractors unite to raise awareness about mental health problems and illnesses and prevent suicide across the construction industry
This September, during National Suicide Prevention Month, the Canadian Construction Safety Council (CCSC) is launching an industry-wide suicide prevention campaign Looking Out For Each Other to raise awareness, reduce stigma and help construction workers, supervisors and leaders recognize that mental health is essential to a safer industry.
Maryland Department of Health releases vaccine recommendations ahead of flu season
The Maryland Department of Health released its 2026-27 statewide vaccine schedules and recommendations for children and adults ahead of flu season.
Patriots get concerning injury update on star WR A.J. Brown
NFL insider Ian Rapoport revealed the latest update on Patriots wide receiver A.J. Brown's ankle injury.
I love the Huawei Watch GT 7 Pro's fresh design: it’s my favorite new fitness wearable
Huawei is on the offensive with its new band of stylish wearables.
Global library trends report on AI, open science, future of libraries
The Pulse of the Library 2026 report surveyed 1,800+ academic, national and public libraries globally on future of the library and trends including the pace of AI adoption
Wyoming becomes 50th state to join maternal care alliance
by Katie Klingsporn, WyoFile LARAMIE—When Wyoming recently joined the Alliance for Innovation on Maternal Health — a nationwide initiative to support best
Romeo Doubs vows to be better after disappointing Patriots debut
The wide receiver finished with zero catches against the Seahawks.
Martin Odegaard Praises Arsenal Fans After Naples Travel Chaos
Martin Odegaard thanked Arsenal's travelling fans after they helped make themselves heard in Naples despite widespread disruption to flights from the UK.
Republicans try to defy history with convention in Dallas
President Donald Trump and party leaders believe that by talking about all the good things that have happened over the last two years, they can boost GOP energy nationwide.
Memos expose secret industry push to kill California plastic laws
Leaked internal memos reveal how a packaging alliance drove a widespread lobbying and marketing campaign to dismantle California’s landmark plastic and recycling laws.
Pa. Republican lawmakers say proposed Department of Health regulations pose privacy concerns
Pennsylvania’s Department of Health is facing widespread pushback from Republican lawmakers who say the agency’s plan for how it would respond to future infectious disease outbreaks would give health officials
Carteret Health Care takes free screenings on the road with countywide stops
CARTERET COUNTY — Carteret Health Care is taking free health screenings on the road this month, with several stops planned across the county.No appointments are
Apple Announces macOS Golden Gate Release Date
Apple this week announced that macOS 27, also known as macOS Golden Gate, will be released to all users with a compatible Mac on Monday, September 14. iOS 27, iPadOS 27, watchOS 27, tvOS 27, and visionOS 27 will be released on the same day. macOS Golden Gate features Siri AI, design improvements, performance enhancements, and more. A developer beta has been available since June, while a public beta followed in July, and now the update will be widely released on September 14.
Students in Asia extend lead over a flagging US as AI reshapes education
High-school students across Asia are pulling ahead of their Western peers, an annual global assessment indicates, as artificial intelligence spurs a worldwide race for talent and reshapes how young people learn.
Patriots WR A.J. Brown leaves field with injury
Patriots wide receiver A.J. Brown limped off the field after suffering an injury in Wednesday's game against the Seahawks.
Around the Net In Media: Thunder Road, Lit Entertainment Founders Launch Media Firm
Basil Iwanyk, founder of Thunder Road Films, and partner Eria Lee are partnering with Lit Entertainment Group founder Adam Kolbrenner to launch TR/AK, a media company focused on creators and original stories. The new company will also pursue ambitious film and television projects that will reach global audiences. Thunder Road has grossed more than $4.4 billion worldwide with its films, and Lit Entertainment clients boast of writing projects that have generated more than $7 billion.
Phoenix firefighters hold department-wide mental health sessions
Every Phoenix firefighter is stepping away from the front lines this week for a one-on-one talk about mental health, trauma and suicide prevention.
Closing health workforce gaps for emergency response: the Western Pacific steps up
Over 100 health emergency experts from 56 institutions across 21 countries in the World Health Organization (WHO) Western Pacific Region who are part of the Global Outbreak Alert and Response Network (GOARN) concluded their annual regional partners’ meeting with a commitment to bridge gaps in emergency workforce capacities and advance regional emergency readiness and resilience.Co-hosted by WHO and the Korea Disease Control and Prevention Agency in the Republic of Korea, the two-day event aimed to strengthen the Region’s collective ability to detect, prepare for and respond to health emergencies.Partners mapped capacities and priority technical gaps across the Region — including cybersecurity and critical infrastructure resilience; water, sanitation and hygiene (WASH) and environmental health; biological emergencies, nuclear emergencies, and nuclear and radiological security.The result: a renewed commitment to close these gaps by working together through shared expertise and coordinated action. Advancing the Global Health Emergency CorpsReflective of regional solidarity and partnerships in action, GOARN – which is coordinated globally by WHO - enables a stronger, better-connected emergency health workforce that is ready to surge wherever and whenever requested by WHO Member States.This year alone, GOARN partners across the Western Pacific have supported nine experts on six missions - from measles outbreaks in Viet Nam to HIV outbreak response in Fiji - providing surge support in epidemiology, surveillance and clinical case management.Photo: Participants at the Global Alert and Response Network (GOARN) Partners Meeting 2026. Credit: KDCA/Shin Dong Myoung“GOARN partners across the Western Pacific and globally have repeatedly demonstrated the power of what we can do collectively, when we join forces, share expertise and build on each other’s strengths,” noted Dr Gina Samaan, WHO Regional Emergency Director for the Western Pacific, in her opening remarks at the gathering. “Let us continue to forge long-term partnerships grounded in mutual respect that will protect the Region for generations to come. We are smarter, faster and infinitely stronger when we work together,” she added.Reiterating Dr Samaan's call, Dr Seung-kwan Lim, Commissioner of the Korea Disease Control and Prevention Agency, emphasized the value of GOARN: “The Republic of Korea is pleased to stand alongside our regional partners in building an emergency workforce that is ready and resilient. GOARN turns national expertise into regional readiness - catalysing national strengths into collective resilience.”GOARN advances the Global Health Security Action Framework (GHEC) initiative by “convening, connecting and capacitating” regional leaders and surge workforce – “the three Cs”. Years of GOARN leadership and outbreak response training programmes have cultivated a deep bench of fit-for-purpose, seasoned outbreak response experts and forged an alumni network of emergency leaders worldwide. The Western Pacific network alone has now grown to 94 partner institutions across 19 countries. Photo: Participants at the Global Alert and Response Network (GOARN) Partners Meeting 2026. Credit: KDCA/Shin Dong Myoung Putting partnerships into practiceDuring the Regional Partners’ Meeting, health experts identified and catalogued the technical expertise currently available across the Western Pacific Region, so that the right skills could be better matched quickly to needs wherever emergencies occur.Three priority areas emerged for further strengthening:Cybersecurity and critical infrastructure resilience - protecting essential systems, including healthcare networks, from digital disruptions.Water, sanitation and hygiene (WASH) and environmental health - reflecting the ongoing nexus between climate change and health.Biological emergencies, nuclear emergencies, and nuclear and radiological security - requiring specialized technical capability that remains limited across many national response systems.Meeting participants reaffirmed their commitment to strengthening workforce capacities in the Region, with a particular focus on these three areas, and to working collectively to better prepare the Western Pacific for the next health emergency.Photo: Dr Gina Samaan, WHO Regional Emergency Director for the Western Pacific, delivers opening remarks at the Global Alert and Response Network (GOARN) Partners Meeting 2026. Credit: KDCA/Shin Dong Myoung“GOARN is truly turning preparedness into action - giving our Region the surge capacity it needs for fast, coordinated response when it matters most - and building more resilient health systems along the way,” said Dr Samaan. “As health emergencies mount in this age of permacrisis, emergency preparedness and response must be woven into the fabric of health. This is not an option, but an imperative as we seek to achieve health for all.”____ About GOARNThe Global Outbreak Alert and Response Network (GOARN), coordinated by the World Health Organization since 2000, strengthens global health security by advancing preparedness for and response to public health emergencies. The network brings together more than 390 institutions, including national public health agencies, technical organizations and nongovernmental partners, to support coordinated international action during outbreaks and other health emergencies. There are 94 GOARN partners in the Western Pacific Region (as of August 2026), accounting for approximately 25% of global partners. For more information and media interviews, please contact: WHO Western Pacific Communications: wprocom@who.intAra Johannes: johannesa@who.int
Does AFC Bournemouth’s Atmosphere "Problem" Raise a Bigger Question?
Despite the emphatic 4-0 win, Bournemouth’s underwhelming atmosphere against Lincoln was tangible, and as The Price of Football recently explored, the Cherries’ growing hospitality offering highlights a wider debate about matchday revenue, premium seating and what makes a stadium truly "valuable".
California, other states warn Supreme Court of 'chaos' if it lets USPS mail ballot rules stand
A federal judge has already halted the plan nationwide, but the Trump administration has asked the Supreme Court to revive it, arguing the federal government would be seriously harmed by voter fraud if it does not.
Motorola teases wide Razr Fold as its ‘next move’ in response to iPhone Duo debut
Apple’s iPhone Duo announcement has triggered a couple of companies, and it’s apparently warranted at least one teaser for even...
Read the Apple document explaining how new listening features still protect your privacy
Will you be using Audio Intelligence?
Saints’ Rookie Named ‘Future Hit’ Ahead of Week 1
The New Orleans Saints still have some questions to be answered at the wide receiver position.If Bryce Lance reaches his potential quickly, though, that could solve a lot of potential issues.And there appear to be at least some people around the league who are big believers in Lance.The Saints took Lance in the fourth round […] The post Saints’ Rookie Named ‘Future Hit’ Ahead of Week 1 appeared first on HEAVY.
MultiCare's statewide layoffs hit Yakima's North Star Lodge, business office
The leader of Tacoma-based MultiCare Health System told The News Tribune on Tuesday the not-for-profit network is cutting 138 positions.
MultiCare's statewide layoffs hit Yakima's NorthStar Lodge, business office
The leader of Tacoma-based MultiCare Health System told The News Tribune on Tuesday the not-for-profit network is cutting 138 positions.
Appeals court considers future of nationwide access to medication abortion
The issue of medication abortion was back before a New Orleans-based appeals court on Wednesday, in the latest iteration of a years-long legal effort to end the provision of abortion drugs via telehealth.
Parker Washington says contract talks with Jaguars "are continuing"
Jaguars wide receiver Parker Washington is hoping to take care of a little business before the regular season gets underway.
Ultimate Fall Arts & Entertainment Guide
A curated guide to the standout music, theater, art and cultural experiences shaping Grand Rapids this fall—from citywide celebrations to can’t-miss exhibitions.
W.Va. expands Medicaid school-based health services
The West Virginia Department of Human Services (DoHS) Bureau for Medical Services and the West Virginia Department of Education (WVDE) are partnering to expand school-based health services, giving more students statewide access to vital medical and mental healthcare.
WVU, state, healthcare partners get $2.4M to recruit, retain, expand medical profession statewide
Building on the foundational success of West Virginia’s premier talent attraction and retention programs, West Virginia University will use $2.4 million to help recruit and retain state-licensed healthcare professionals by standing up three new programs: Ascend WV Healthcare, First Ascent Healthcare, and a new pilot program that extends beyond the current 23-county Ascend WV and First Ascent network.
Allina Health doctors file 10-day strike notice
MPR News host Cathy Wurzer spoke with Dr. Saul Singh, bargaining team member for the Doctors Council SEIU, about the strike notice.
Saints Sign Former Unclaimed Broncos Player From 4 Free Agents
With the opener right around the corner, New Orleans brought a handful of former vets in for a look on Tuesday, quietly trying to shore up the depth chart behind Chris Olave.It’s no secret that New Orleans is leaning heavily on young receiving corps behind Olave, making a late-week workout session with the free wideout […] The post Saints Sign Former Unclaimed Broncos Player From 4 Free Agents appeared first on HEAVY.
Garrett Wilson: Jets Making Playoffs This Season 'Very Realistic'
New York Jets star wide receiver Garrett Wilson thinks making the playoffs this season is "very realistic."
WOW! Gives Businesses a Simple Way to Manage and Enhance Their Online Presence
/PRNewswire/ -- WideOpenWest, Inc. (WOW!), a leading provider of fiber-broadband internet services and advanced connectivity solutions, today announced the...
Local Business Owners Start New Chapter with Opening of New PostalAnnex Location in Concord, California
Annex Brands, Inc., one of the leading franchisors in the packing, shipping and office services industries, is excited to announce the opening of its newest PostalAnnex location in Concord, CA to new owners, Rebeccah and Konstantin Rybalsky. This new PostalAnnex is set to offer a wide range of essential shipping and office services to the local community, making it easier to provide more service to more people in more places.
AT&T Business and Amazon Leo form strategic partnership
AT&T Business and Amazon Leo have agreed to bring broadband services to AT&T Business customers nationwide, making AT&T is the first major U.S. telecom provider to offer converged connectivity solutions that include Amazon Leo’s low Earth orbit (LEO) satellite services. With the agreement, AT&T Business customers have multiple access connectivity options, which the company said […]
Montreal-Based Proteus Labs Partners with Avantis Education to Bring Immersive Virtual Science Labs to Classrooms Worldwide
Proteus Labs, a Montreal-based developer of immersive mixed reality science lab applications for K–12 education, today announced that its unique mixed reality science lab application has been selected to be part of Avantis Education's ClassVR Xcelerate headset and new EduverseSTEM platform, extending hands-on virtual science experiments to schools in 90 countries.
Dutch staffing industry rates outpace wider business services
Overall revenue in the temporary staffing sector climbed 5.8% compared with the same period last year.
Seminoles Surrender Back Breaking Play in 4th Quarter
FSU suffered a blow in the fourth quarter when SMU wideout Yannick Smith caught a 79 yard touchdown. Even though FSU responded, it was the biggest explosive play of the game, and the one that sticks out the most when you consider SMU had three plays of 50 yards or more, and eight plays of +15 yards.
Apple expected to unveil first folding phone, with new CEO Ternus in command
Apple is widely expected to unveil a pricey folding iPhone at a launch event on Wednesday at its Cupertino, California, headquarters.
This Founder Built a $220 Million Fitness Business. His Playbook Comes Down to 4 Decisions
Tony Hartl has grown Undefeated Tribe, his master franchise for Crunch Fitness, to 4,000 employees and systemwide revenues of $220 million. Here's how.
Did New Film Unit Just Shift AMC Stock’s Investment Narrative?
AMC Entertainment Holdings recently launched Leawood Films, a film distribution unit based in Los Angeles and Leawood, Kansas, aiming to bring more small and mid-sized movies into theatres worldwide while relying on fully financed projects to limit production risk. The new distributor uses AMC’s excess screen capacity and past concert-film marketing experience to secure theatrical placement for filmmakers who might otherwise struggle to find backing, while leaving most downstream revenue and...
🗞️ Today’s front pages, tension in Madrid, Betis delight...
The Champions League has thrown its doors wide open with a menu full of contrasts for Spanish football: Real Madrid’s emphatic yet hard-fought win, an epic and historic victory for Real Betis after ...
Perea Rejoins FGI Risk as Director of Business Development
FGI Worldwide, a provider of working capital financing and trade credit insurance solutions, readded Rick Perea to FGI Risk as director of business
Study Findings Conflict with Body of Science Linking Pesticides to Attention Deficits and Autism - Beyond Pesticides Daily News Blog
A recent study finds no connection between levels of urinary biomarkers of organophosphates and autism-related traits, conflicting with a wide body of research.
Hurricane Lowell forces bank closures across Kauai, parts of Oahu and Maui
All major Hawaii banks closed Kauai branches Tuesday as Hurricane Lowell brought high winds, heavy rain and widespread power outages to the islands.
COVID-19 infections rise across California as health officials urge vaccinations
California health officials are encouraging residents to stay up to date on COVID-19 vaccinations as infections increase statewide.
The trail of clues that our planet might be heating faster than we realised
A curious online row over this summer's heatwaves points to a wider - and worrying - shift in climate science.
The trail of clues that our planet might be heating faster than we realised
A curious online row over this summer's heatwaves points to a wider - and worrying - shift in climate science.
All North Carolina student IDs will have mental health resources printed on them as part of the Student Helpline Act
RALEIGH, N.C. (WNCN) — Today is 988 Day, a nationwide event dedicated to promoting mental health support and suicide prevention through the 988 Suicide & Crisis Lifeline, and now, in North Caro…
Apple wanted the iPhone Ultra to cost $1,999, new report says
But the RAM apocalypse intervened. Apple is holding its big annual iPhone launch event on September 9, and it's widely expected to unveil the iPhone Ultra...
Pritzker-backed PAC plans to bankroll anti-Trump candidates nationwide
The committee, called “Ready for the Fight” in reference to a line from Pritzker campaign speeches, launched today.
988: September 8 marks nationwide awareness campaign for mental health crisis lifeline
Georgians are being asked to tell a friend about 988 as part of a nationwide campaign marking September 8.
Supporting small business across North Dakota
ND SBDC State Director Tiffany Ford joins ‘North Dakota Today’ to discuss the organization’s statewide impact
The Galaxy Z Fold 8 is outselling Samsung's record-breaking Fold 7 by a wide margin
Samsung finally explained the engineering behind the gap.
Israel to mandate Iodine in table salt amid widespread deficiency
Studies have found widespread iodine deficiency in Israel, particularly among pregnant women and children. The condition can cause thyroid problems and, in severe cases, developmental and neurological damage
Environmentalist photographer kicks off A.D. White Professors-at-Large series
James Balog will discuss his work documenting the world-wide rapid retreat of glaciers on Sept. 17 as part of the visiting professors program.
Endometriosis can go undiagnosed for years. Here's what to know
Endometriosis afflicts 1 in 10 women worldwide, but diagnosing the painful disease is a challenge. New tests being used in other countries could help.
Republicans were confident about keeping the Senate. Now the battle is wide open
Republicans appeared to have a firm grip on the majority at the start of the 2026 election cycle. But Democrats are now competing in states that once seemed well beyond their reach.
Growth in every postcode: good politics, dubious economics
The UK government would be better off backing clusters and widening access to opportunity
SKY BLUE CINEMATIX - ENTERTAINMENT - BRAND INTEGRATION : Two Films. One Global Partnership.
Sky Blue Cinematix appointed exclusive worldwide brand-integration partner for two new features from Tested Films....
SKY BLUE CINEMATIX - ENTERTAINMENT - BRAND INTEGRATION : Two Films. One Global Partnership.
Sky Blue Cinematix appointed exclusive worldwide brand-integration partner for two new features from Tested Films.London, UK, Sept. 08, 2026 (GLOBE NEWSWIRE) -- Sky Blue Cinematix, the entertainment and brand-integration division of Sky Blue Media Group, today announced its appointment as the exclusive global brand-integration partner for two upcoming feature films from Tested Films: the action thriller Habeas Corpus and the neo-noir romantic mystery Blurred. Sky Blue Cinematix appointed exclusi
Aaron Rodgers praises Karl Ravech for ‘phenomenal’ ESPN tenure
Aaron Rodgers loves to hate on ESPN, and the Worldwide Leader may have given him a little more ammunition by parting ways with Karl Ravech. Rodgers was recently interviewed by Adam Schein on his SiriusXM Mad Dog Sports Radio show. At the end of the segment, Schein boldly gave Rodgers the open forum to share…
New-to-science Amazon frog stands out for its slow ‘lazy’ song
Scientists recently described a new species of a tiny brown frog found in the Amazonian floodplain forests of Ecuador and northwestern Brazil. It looks nearly identical to related species but its slow, widely spaced out call sets it apart, researchers note in a study. “I’ve had to get into arguments because people said the frog […]
Roundup: Energy employment / Small business confidence / Maritime woes
Jobs in transition: Energy sector employment fell about 1% nationwide and in Louisiana from 2024 to 2025, with Louisiana losing 1,131 jobs to reach roughly 160,000 workers. The decline was driven largely by automation, policy changes affecting renewable energy, and shifting economics, while traditional energy industries such as coal and nuclear saw job growth. Despite […]
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
How Is Hilton Worldwide's Stock Performance Compared to Other Leisure and Entertainment Stocks?
Hilton Worldwide has outperformed the Leisure and Entertainment industry over the past year, and analysts are cautiously optimistic about the stock’s prospects.
Black business conference urges unified statewide economic action
The Illinois State Black Chamber of Commerce will bring Black business owners, contractors, financial leaders, executives and civic organizations together
More than 1.6 million people die each year from secondhand smoke
The share of the population exposed to tobacco smoke is falling, but more than 2.7 billion people worldwide are still affected
Cutting Darius Slayton is a move the Giants might regret
With a lot of question marks at wide receiver, the Giants still rolled the dice by letting Slayton go.
Your personality may be more genetic than scientists realized
More than 1,200 genetic variants have been linked to the Big Five personality traits, and many of the same variants are also associated with health, longevity, careers, income, and everyday habits. The findings reveal a surprisingly wide genetic connection between personality and life outcomes while showing that environment still plays a powerful role.
Did California forget about its zero-emission school bus project?
“Considering the state’s requirement for all school buses to be zero-emission by 2035, more sustained statewide support is needed.”
Commanders draft national champion WR in latest 2027 mock draft
ESPN predicts the Washington Commanders will draft Indiana wide receiver Charlie Becker with the No. 10 overall pick in the 2027 NFL Draft.
Alabama Department of Mental Health highlights life-saving resources for Prevention, Recovery Months
This September, the Alabama Department of Mental Health and statewide partners are working to raise awareness, fight stigma, and share life-saving resources.
Alabama Department of Mental Health highlights life-saving resources for Prevention, Recovery Months
This September, the Alabama Department of Mental Health and statewide partners are working to raise awareness, fight stigma, and share life-saving resources.
Alabama Department of Mental Health highlights life-saving resources for Prevention, Recovery Months
This September, the Alabama Department of Mental Health and statewide partners are working to raise awareness, fight stigma, and share life-saving resources.
Alabama Department of Mental Health highlights life-saving resources for Prevention and Recovery Months
This September, the Alabama Department of Mental Health and statewide partners are working to raise awareness, fight stigma, and share life-saving resources.
Grand Theft Auto 6 worldwide unlock times revealed, and Xbox owners can seemingly still use the old New Zealand trick to play early
A lot of Xbox owners will be teleporting to New Zealand to play Grand Theft Auto 6 at the earliest possible moment.
Iowa high school football schedule Week 3: Every IHSAA game
See the statewide schedule of Iowa high school football games in Week 3 of the IHSAA season.
One of America's Most Widely Consumed Ingredients Linked to Metabolic Changes And Obesity
"It's not the oil itself ... It's what the fat turns into inside the body."
Colts' Shane Steichen Gives Alec Pierce Update for Week 1
Indianapolis Colts wide receiver Alec Pierce recently returned to practice following ankle surgery, but will he be ready for this Sunday against the Baltimore Ravens?
Medicare now covers CBD, but Congress wants to ban it
CBD use for medicinal purposes is not a fringe movement. It is a nationwide phenomenon of informed adults seeking more choice in health care.
Buffalo Bills WR Predicted to Have Career Year in 2026
The Buffalo Bills could see one of their young offensive weapons take a major step forward in 2026, with a bold prediction pointing toward a career year for Keon Coleman. The second-year wide receiver enters the season with an opportunity to establish himself as a more consistent and productive target in Buffalo’s passing attack. Coleman […] The post Buffalo Bills WR Predicted to Have Career Year in 2026 appeared first on Gridiron Heroics.
Apple to Make First Big Change to iPhones in Years
Fans of the company’s products widely believe it will unveil a folding smartphone at its annual launch event on Wednesday.
Why getting your hands dirty is good for you
Putting our hands in soil and touching grass, trees or moss provides a wide range of health benefits, for our skin and wider immune system.
Why getting your hands dirty is good for you
Putting our hands in soil and touching grass, trees or moss provides a wide range of health benefits, for our skin and wider immune system.
“It’s normal” Kessie breaks silence on snubbing Juventus for Atalanta
Franck Kessie was widely expected to move to Juventus this summer as a free agent, and he tried his best to make the transfer happen. The midfielder waited patiently for Juve to offload some players a...
Xiaomi’s wide foldable promises more power than Samsung’s
Xiaomi is the latest to hop on the wide fold bandwagon
What role for science in Swiss democracy and worldwide?
In Switzerland, people have more trust in science than in the police or government.
Second-Year Wide Receiver Next Man up For Washington Huskies
Chris Lawson will be a fixture with the Huskies due to the injury to sixth-year wideout Christian moss.
Ozempic and GLP-1 agonists: Science magazine analysis
Science magazine analyzes the widespread use of Ozempic and GLP-1 agonists, warning of the risk of increasing social inequalities and calling for WHO intervention.
New York Giants Cut Their Longest-Tenured Player Darius Slayton
In a surprise move on Monday, the New York Giants cut wide receiver Darius Slayton. Slayton was the longest-tenured Giant, […]
The GOP was confident about keeping its Senate majority. Now the fight for control is wide open
WASHINGTON (AP) — Republicans appeared to have a firm grip on the Senate heading into the final two years of President Donald Trump’s term. But with less than t