SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " cardi " 1,790 found π AI-powered Shuffle
Red Sox eager to build momentum in finale vs. Cards
Brayan Bello will take the mound on Sunday afternoon against the St. Louis Cardinals as the Boston Red Sox try to win their second consecutive series and first one on the road this season.
3 diet tweaks heart health nutrition scientist made to prevent disease
How quickly and when you eat could affect your metabolic and cardiovascular health, professor Sarah Berry said.
2026 NFL draft preview: Linebacker prospects and the Arizona Cardinals
Jess Root and Seth Cox talk about linebacker prospects to know for the Arizona Cardinals in the 2026 NFL draft.
Where to Watch Boston Red Sox vs St. Louis Cardinals Live Stream, TV Channel for Saturday, April 11, 2026
The Red Sox and Cardinals continue their series in St. Louis on Saturday.
2026 NFL mock draft 8.1: Cardinals surprise with their picks (yes, plural), while Giants take a weapon at No. 5
FSU softball falls to Stanford on walk-off grand slam
The Stanford Cardinal beat the FSU with a walk-off grand slam to snap their 25-game winning streak.
Microplastics in our bodies: What health experts are starting to see
Join leading medical experts, including cardiologists and public health researchers, for a timely conversation on the emerging science around microplastics and the human body.
2026 NFL mock draft 8.1: Cardinals surprise with their picks (yes, plural), while Giants take a weapon at No. 5
SVS quality initiative gathers data to improve vascular care
More than 7,000 physicians from a wide variety of healthcare specialties are already participating in the project.
Missouri sports betting is now live: See the best sports betting apps to snag over $3,000 in launch promos
Missouri sports betting is now live, and the top Missouri sportsbooks are offering Missouri sports betting promos
Rasoul: Medicare for All is good for business
One of the most overlooked points in the argument for a federal single-payer health insurance system is how great it would be for business. A single-payer system would not only give businesses a huβ¦
The lifesaving catch that changed everything
Javon Brumsey's lifesaving catch saw him take on heart surgery and recover with the ECU Health Cardiovascular and Pulmonary Rehab program.
Cardio vs. Strength: Cardiologist on Which Is Better for Heart Health
In TODAY.com's Expert Tip of the Day, a cardiologist weighs in on the best type of exercise routine for heart health and heart disease prevention.
2026 NFL draft: Top 12 of Top 100 prospects
NFL.com's Eric Edholm updated his top 100 prospects. Here are the top 12.
New gene therapy may help protect the hearts of patients with Friedreich's ataxia
A majority of deaths from Friedreich's ataxia are associated with heart complications. A new treatment years in the making could provide some much-needed relief.
Orioles-Cardinals Trade Brings Relief To An Injured O's Bullpen
The Baltimore Orioles added bullpen depth on Tuesday by acquiring left-hander Nick Raquet from the St. Louis Cardinals in exchange for infielder/outfielder Brayden Smith. According to the Orioles X account, Raquet has not yet reported to the team; Raquet was designated for assignment by the Cardinals on Sunday. On Monday, the Orioles placed left-hander Dietrich Enns on the 15-day injured list with a left foot infection and called up right-hander Brandon Young to start Monday against the Chicago White Sox.
NFL mock draft: Arizona Cardinals take Rueben Bain 3rd overall
Sam Monson dropped his mock draft on his podcast. See who the Arizona Cardinals' pick is at third overall.
Fan dies after cardiac arrest at German Bundesliga soccer game
A long-time Eintracht Frankfurt supporter died in hospital, aged 87, hours after suffering a cardiac arrest in the stadium during a German Bundesliga game, the club said Tuesday. The stadium fell silent as paramedics worked to revive the man, who hasn't been named, during the second half of Frankfurt's 2-2 draw with Cologne on Sunday. In October, another fan died after falling ill while entering the stadium at a German Cup game between Leipzig and Energie Cottbus.
2026 NFL draft: Arizona Cardinals, Garrett Nussmeier matched
SI.com's Justin Melo matched a developmental prospect with every NFL team. The Cardinals' match is a QB.
A night of two national titles for U-M, as scientists and basketball players both triumph
On the same night that the U-M men's basketball team triumphed in the NCAA tournament, U-M cardiovascular researchers won a national tournament of science
Arizona cardiology practice paying $3.85M to resolve lawsuit after data breach
The 2023 incident potentially gave an attacker access to the names, addresses and Social Security numbers of thousands of heart patients.
Business owner: Donβt look now, but Roanoke is quietly becoming Virginiaβs Music City
Roanoke did not set out to become a music city in the way larger markets brand themselves. It got here the old-fashioned way. One room at a time. One crowd at a time. One show at a time.
Longtime supervisor sues Cardinal Health over age and gender bias
The complaints that allegedly led to his firing included saying "good morning"
Jordan Walker Crushes Grand Slam, But Tigers Outslug Cardinals 11-6
Saturdayβs game began with Dustin May on the mound for the Cardinals and Jack Flaherty for the Tigers, but neither was sharp and the game ended up being a slugfest including a grand slam from Jordan Walker, but the Tigers would rock Dustin May and the Cardinals bullpen and win 11-6 after being called an [β¦]
Young Adults With High Blood Pressure Face Higher Risk of Heart, Kidney Disease
Recent research suggests that adults ages 30 to 40 with high blood pressure may face a higher risk of cardiovascular and kidney disease later in life. These findings highlight the importance of maintaining a healthy blood pressure at a younger age.
Missouri sports betting market officially launched: $5,000 in sportsbook sign-up bonuses, promos in April
Missourians can now place sports bets with mobile sportsbooks and get Missouri sports betting offers for the Missouri betting launch
Springfield deli had mold growing in pizza sauce: Health department
Springfield-Greene County Health Department inspectors found mold growing in pizza sauce at a deli, which was corrected by discarding the sauce.
Migration can influence cardiovascular risk profiles, study shows
A new study shows that migration from Mexico to the United States can influence cardiovascular risk profiles. The study's findings are important for clinicians who serve immigrant populations and who ...
Iterative Health, US Heart & Vascular Partner to Advance Community-Based Cardiovascular Research
April 2, 2026 β Iterative Health and US Heart & Vascular (USHV) have announced a strategic partnership to advance research through community-based innovation in cardiovascular care. "Clinical research is one of the most powerful ways we expand access, improve patient outcomes, and shape the future of cardiovascular care," said Robbie Allen, chief executive officer of US Heart & Vascular. "By partnering with Iterative Health, we are strengthening our ability to bring innovative therapies directly into the communities we serve. This collaboration ensures our physicians and patients have access to leading-edge trials while allowing US Heart & Vascular to remain focused on delivering exceptional, physician-led care." Under the agreement, USHV research sites will join Iterative Healthβs global site network, which now spans over 100 sites across three continents. The companies share a commitment to advancing clinical research as a driver of care innovation, and this collaboration represents a major milestone for both organizations, strengthening USHV's leadership in community-based cardiovascular research and expanding Iterative Health's multispecialty focus beyond GI, hepatology, and obesity into cardiology. USHV clinical research sites will gain access to Iterative Health's centralized operational backbone, providing end-to-end support across clinical research operations, services, business development, technology innovation, and corporate functions. The strategic partnership reduces operational complexity and unlocks growth potential for USHV research sites while enabling all USHV physicians to expand access to cutting-edge therapies to the thousands of patients they serve annually. "Innovation in cardiovascular medicine shouldn't be limited to a few academic centers," said Thomas Waggoner, DO, MD, RPVI, FACC, FSCAI, FSVM, RPVI, Structural Cardiologist and Medical Director for Clinical Research at Pima Heart & Vascular, and USHV Physician Champion for Clinical Research. "By expanding community-based research across USHV, we're ensuring more patients have access to clinical trials and breakthrough therapies close to home, where trusted relationships with their physicians already exist." This alliance reinforces Iterative Health's standing as the definitive research partner across specialized therapeutic areas, now spanning GI, hepatology, obesity, and cardiovascular care. Trusted by many of the nation's leading provider organizations and biopharma sponsors, Iterative Health's global site network delivers industry-leading trial performance, accelerating life-changing therapies to market at scale. "Entering cardiology through our strategic partnership with US Heart & Vascular is a defining moment for Iterative Health and reflects the strength of our site-serving model," said Jonathan Ng, founder and CEO of Iterative Health. "Together, we are ensuring that thousands of patients have access to the newest available therapies, and that sponsors have a credible, high-performing partner to accelerate cardiovascular trial success." For more information, visit www.iterative.health and https://usheartandvascular.com/.
Cardinals shortstop Masyn Winn 'OK' after single-car accident
Winn was hospitalized but suffered no serious injuries
2026 NFL seven-round mock draft: Steelers, Jets, Cardinals among teams targeting QBs as 11 come off the board
From the No. 1 overall pick to Mr. Irrelevant, here's how every team builds its 2026 class.
Panoramic Health and West Coast Kidney Institute Launch Concord Cardio-Renal Research Institute to Advance Clinical Trials in Cardio-Renal-Metabolic Disease
/PRNewswire/ -- Panoramic Science, the clinical research division of Panoramic Health, and West Coast Kidney Institute today announced the launch of the...
LA Chargers help high school athletes learn lifesaving CPR
More than 250 high school student-athletes from across the Los Angeles Unified School District spent a day learning about heart health alongside Los Angeles Chargers players.Students learned hands-only CPR, met Chargers players Elijah Molden and RJ Mickens in UCLA Health Sports Performance Training, Powered by Exos, and enjoyed lunch on the patio at Huddle for Heart Health, held March 19 at The Bolt, the Chargersβ official practice facility in El Segundo. RJ Mickens, left, and Elijah Molden joined more than 250 LAUSD high school students at the Huddle for Heart Health event. (Photo courtesy of Joaquin Torre/Los Angeles Chargers) Along with learning CPR techniques, students practiced performance training on the LA Chargers practice field in El Segundo. (Photo courtesy of Joaquin Torre/Los Angeles Chargers) LA Chargers defensive back RJ Mickens visits with high school students at the Huddle for Heart Health event. (Photo courtesy of Joaquin Torre/Los Angeles Chargers) The event was presented by UCLA Health, the American Heart Association, the Los Angeles Chargers and LAUSD.Hands-only CPR is a lifesaving skill, said David Sato, MD, board president of the American Heart Association Los Angeles.βWe save more lives when we work together,β said Dr. Sato. βThis collaboration with UCLA Health and the Los Angeles Chargers to teach students how to perform hands-only CPR helps ensure more families in Los Angeles have someone ready to act in a cardiac emergency when seconds count.βHands-only CPR is a lifesaving procedure for cardiac emergencies that doesnβt involve rescue breaths. It involves pressing hard and fast in the center of the chest of a teen or adult who has collapsed. Pressing can be done to the beat of the Bee Geeβs hit βStayin' Alive, which, at 100 beats per minute, is the minimum rate at which to push during hands-only CPR, according to the American Heart Association. LA Chargers defensive back Elijah Molden, standing, helps high school students learn CPR skills. (Photo courtesy of Joaquin Torre/Los Angeles Chargers) Most cardiac arrests that donβt happen in the hospital happen at home, and hands-only CPR is as effective as CPR with breaths in the first minutes following a cardiac emergency.
Cardiologist Reveals Favorite Exercise Class For Workout Variety
In TODAY.com's Expert Tip of the Day, a cardiologist reveals how she unexpectedly discovered a "really intense workout" and why a variety of workouts boosts longevity.
Parkinson hails Wrexham Women's Adran Premier success
Wrexham men's first team manager Phil Parkinson has congratulated the Women's team on clinching the Adran Premier title for the first time. Jenny Sugarman's side beat defending champions Cardiff City 4-1 at the Stok Cae Ras last Sunday, with Parkinson among the spectators. Wrexham, who will represent Wales in the Champions League, will receive the Adran Premier trophy when they face Swansea City in their final game on Sunday.
Digital heart twins can guide a lifesaving procedure
The "digital twins" helped doctors spot good targets for heart ablation in 10 patients. Months later, all of them are free of sustained faulty rhythms.
US Cardiologists Have Just Published New Guidelines For Managing Cholesterol
How to detect it and lower it.
Cardinal Health expands Actinium-225 production capacity to support growing demand for novel cancer therapies
/PRNewswire/ -- Cardinal Health (NYSE:CAH) today announced a significant expansion of its Actinium-225 (Ac-225) production capabilities at the company's Center...
Danville business owners say theyβre still waiting for traffic boost from casino
Part of Danvilleβs goal in bringing in Caesars Virginia was to capitalize on increased visitation by sending out-of-towners to other parts of the city. Some business owners have seen this happen, aβ¦
Larry Fitzgerald investing in new professional flag football league
Former Cardinals receiver Larry Fitzgerald is among the many past and present NFL players backing a new, yet-to-be-named professional flag football league.
NFL approves small changes to officiating in 2026
The league is preparing for the possibility of replacement officials in 2026.
Cardiovascular health in pregnancy according to Lifeβs Essential 8 score
npj Cardiovascular Health - Cardiovascular health in pregnancy according to Lifeβs Essential 8 score
Cardi B and Steph Curry earn Webby Award nominations, along with Sydney Sweeney's bathwater
f s e media-and-entertainment-industry software podcasts sports technology language celebrity politics internet business entertainment | KMBZ
St. Tammany Health System opens new cardiology center
The new Cardiology Center at St. Tammany Health System was dedicated March 25 during a ribbon-cutting ceremony attended by health system leadership, members of the medical community and local officials.
Cardi B and Steph Curry earn Webby Award nominations, along with Sydney Sweeney's bathwater
f s e media-and-entertainment-industry software podcasts sports technology language celebrity politics internet business entertainment | KNX News 97.1 FM
UK HealthCare announces new director of Gill Heart & Vascular Institute
After an intensive national search and selection process, UK HealthCare leadership announced that Vedant Gupta, M.D., has been selected as the director of the Gill Heart & Vascular Institute and leader of the cardiovascular health service line.
Arizona Cardinals NFL draft needs: Defensive line
A look at where the draft priority should be for the defensive line positions, based on roster needs.
Cardinal Health recognized by industry peers for leadership in supplier transparency and resiliency
Recognition from Healthcare Industry Resilience Collaborative (HIRC) based on healthcare providersβ nominations. Our Global Medical Products and Distribution (GMPD) business was presented with...
Following 9 key steps for a lifetime of eating well can support heart health
Statement Highlights: Sustaining lifelong healthy eating patterns may reduce the risk of cardiovascular disease and other chronic health issues, according to the latest updated dietary guidance offered in a new scientific statement from the American...
Cardi B and Steph Curry earn Webby Award nominations, along with Sydney Sweeney's bathwater
This yearβs Webby Award nominations highlight the internetβs wildest hits, from celebrity campaigns to strange viral products.
Boone Health sues cardiology group; coverage change to affect over 20K patients
Boone Health filed a lawsuit against Missouri Heart Center, alleging the cardiology group is trying to open a new clinic in Columbia.
Helen H. Hobbs, M.D., honored for innovation in cardiovascular science
Helen H. Hobbs, M.D., Professor in the Eugene McDermott Center for Human Growth and Development and of Internal Medicine and Molecular Genetics at UT Southwestern Medical Center, has been named the recipient of the 2026 Valentin Fuster Award for Innovation in Science by the American College of Cardiology (ACC).
Cardiac Electrophysiology Expertise Now Offered at UAMS Health Family Medical Center in Fort Smith
LITTLE ROCK β The University of Arkansas for Medical Sciences (UAMS) Health Heart Center now offers comprehensive cardiology services at the UAMS Health Family Medical Center in Fort Smith. The services are provided by cardiologists Subodh R. Devabhaktuni, M.D., Risheek Kaul, M.D., and Paul Mounsey, M.D., Ph.D. Cardiology servicesβ¦
The tragedy of Adam Ankers β and why his family want football to learn from his death
Nobody knew Adam Ankers had a genetic heart condition. Two years after his death, it has to be hoped that his legacy is to make sport safer
Private equity is eying Asiaβs healthcare funding gap as countries get wealthier and older
βAsia has more diabetes, cancer and cardiovascular patients than anywhere else in the world,β Abrar Mir, co-founder of Quadria Capital, says.
Sleeping 11 minutes longer each night shows surprising health benefit, study finds
New research finds that small daily habits, including 11 more minutes of sleep and extra vegetables, are linked to a 10% lower cardiovascular risk.
NFL mock draft: Another 7-round Arizona Cardinals simulation
In this seven-round simulation, the Cardinals make one trade and land players to fill many needs.
βPractice-changingβ interventional cardiology research grabs ACC.26 spotlight
The second day of the American College of Cardiologyβs annual conference started with a series of highly anticipated interventional cardiology trials.
Rural students get hands-on heart science experience
Jefferson County teacher Jasmine Change-Jones launched the 'Heart of Science' lab, giving rural students hands-on learning about cardiovascular health.
With the Cardinals Intent on Protecting the Health of Ivan Herrera, the Club Could Notch A Statistical Oddity Early in the Season
Game Discussion for St. Louis Cardinals vs Tampa Bay Rays
After a rousing come from behind Opening Day victory, the St. Louis Cardinals will attempt to maintain their perfect 2026 record with a Saturday afternoon game versus the Tampa Bay Rays. According to MLB.com, Michael McGreevy will make the start for the Cardinals while Joe Boyle will take the mound for the Rays. Hereβs the [β¦]
What time is Michigan vs Louisville in Sweet 16 today? Start time, location, TV Channel
Everything you need to know to tune into No. 2 Michigan Wolverines vs 3 Louisville Cardinals including start time and streaming options for the Sweet 16
A nutrition scientist shared 3 food swaps for heart-healthy meals
Professor Sarah Berry, a nutrition scientist who specializes in cardiovascular disease, said getting the basics right can go a long way toward supporting our heart health.
2026 NFL draft preview: Quarterback prospects and the Arizona Cardinals
Jess Root and Seth Cox talk quarterbacks in the NFL draft in their first position preview for the 2026 draft.
Missouri sports betting market officially launched: $5,000 in sportsbook sign-up bonuses, promos right now
Missourians can now place sports bets with mobile sportsbooks and get Missouri sports betting offers for the Missouri betting launch
Rays squander Opening Day lead, fall to Cardinals
The Opening Day contest was tied at 1-1 in the sixth inning before the teams combined for the 14 runs.
Cardinals Hosting Inaugural Women's Flag Football Championship Presented By Dignity Health
Top West Coast collegiate teams compete for GSAC Title
Photos: Pro Football Cares Sports Emergency Response Training at Raiders HQ
A Pro Football Cares Sports Emergency Response Training was held at Raiders HQ where athletic trainers and coaches were able to participate in a series of simulations on football equipment removal, cardiac arrest and exertional heat stroke.
Cardiologist's 3 Favorite High-Protein Foods to Boost Heart Health
In TODAY.com's Expert Tip of the Day, a cardiologist shares her favorite foods to add more healthy protein to her diet in a heart-healthy way.
Cardinal Health (CAH) Emerged as a Key Contributor on Pharmaceutical Strength and Margin Expansion
Renaissance Investment Management, an investment management company, released its Q4 2025 βLarge Cap Growth Strategyβ investor letter. A copy of the letter can be downloaded here. The strategy faced a difficult fourth quarter of 2025, underperforming both the S&P 500, which gained 2.7%, and the Russell 1000 Growth Index as market leadership remained concentrated in [β¦]
Cone Health Cardiologist Named 2026 RISE Health Care Hero
Dr. Kardie Tobb wins National Award
Former Cardinals players & coaches in the UFL
Keeping the dream alive
Stopping GLP-1 drugs like Ozempic erodes heart health benefits quickly, new study finds
Stopping GLP-1 drugs like Ozempic quickly erodes heart protection, with two years off the medication raising cardiovascular risk by 22%, a new study finds.
Jack Gibbens reflects on βbittersweetβ decision to leave Patriots
Gibbens signed a two-year deal with the Cardinals in free agency.
Cardinal Health Appoints Patricia A. Hemingway Hall as Board Chair
/PRNewswire/ -- Cardinal Health (NYSE: CAH) today announced that its Board of Directors has appointed Patricia A. Hemingway Hall to succeed Gregory B. Kenny as...
Full 7-round Arizona Cardinals mock draft simulation
We have a new 7-round mock draft for the Arizona Cardinals.
Phillies pitcher Daniel Robert stable after second medical emergency in six months
Daniel Robert suffered a cardiac event Sunday β the second in six months β but was stable after his defibrillator activated
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinksβthe process known as involutionβwith progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) donβt capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, Iβm going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. Thereβs a lot to this algorithmic development, so I wonβt go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bedβs 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSLβs holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any βmagicβ pixel, and occlusion sensitivity, demonstrating the modelβs performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smokerβs paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months weβve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or βinflammaging,β from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus glandβs production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesnβt have impact on the thymus in aged rodent models. In contrast, The liverβs hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of Ξ²-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: βThe proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.β Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor ΞΊB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that weβd be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. Weβve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldnβt have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But itβs not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesnβt clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As Iβve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patientβs immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: βI also wanted to say that your Substack on βWhy We Need an Immunomeβ was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.β Just having an assessment of a personβs immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a personβs specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a personβs risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through oneβs life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please donβt hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributedβthey have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Arizona Cardinals GM perhaps gave hint about Michael Wilson's future
We compare what Monti Ossenfort said this offseason about Michael Wilson with what he said about Trey McBride last year.
Early Menopause Linked to 40% Higher Risk of Cardiovascular Disease
Women who go through natural menopause before age 40 face a 40% higher lifetime risk of coronary heart disease. Black women are three times as likely to experience early menopause as white women.
Arizona Cardinals sign former Titans OL Uli Udoh
The Cardinals signed a fourth free agent offensive lineman with positional versatility and starting experience.
Researcher: Addressing runaway college sports spending in Virginia
This whole college sports enterprise is business development that is being financed by student subsidies, and frequently ever higher student loan debt. As a society, do we do this for any other foβ¦
Get an Lp(a) test β and 3 other things you must do now for heart health
Iβm a cardiologist. Here are the most important new guidelines that younger people need to know about when it comes to their heart health.
Cycle Nova: Villanova students unite to honor a legacy and advance heart health
Villanova, Pa., March 17, 2026 β Beat for Good, Villanova Universityβs studentβrun organization dedicated to supporting individuals and families affected by cardiovascular disease, hosted its inaugural cycling fundraiser, Cycle Nova, on Saturday, March...
Roanokeβs Berglund Center was built for the entertainment landscape of 1971. That world doesnβt exist today.
The lack of big shows or big games is not a failure of management or marketing, itβs simply a fundamental change in the entertainment market. Roanoke needs to keep that in mind as it contemplates aβ¦
Two rules changes proposed ahead of league meeting
The Steelers have a solid rule change proposal for the annual league meeting. The Browns have a questionable one.
Cardinals Nab Key Patriots LB, Signs Two-Year Contract
The Arizona Cardinals have signed New England Patriots free agent linebacker Jack Gibbens to a two-year contract.
New obesity statistics highlight importance of preventive cardiology
Cardiovascular health is much worse in some parts of the United States than others. Cardiologists in those high-risk areas can make a world of difference by embracing preventive cardiology and working to treat patients before it is too late.
Arizona cardiology group pays $4.75M over unnecessary care allegations
Tri-City Cardiology, a Phoenix-area physician group, has agreed to pay millions to resolve allegations of unnecessary care.
Young men and heart health
The study revealed that men start developing cardiovascular disease years earlier than women, with cardiac risk differences beginning as early as their mid-30s.
Earlier Cholesterol Testing Can Reduce Heart Attacks and Strokes, New Guideline Says
Eleven medical organizations advised changes to preventive cardiac care that it says could markedly reduce heart attacks and strokes.
Kyler Murray joins Vikings, whom 2-time Pro Bowl QB grew up rooting for, following release by Cardinals
Kyler Murray lands with Vikings on one-year deal after Cardinals release former No. 1 pick
The two-time Pro Bowler gets a clean slate in Minnesota.
Cardinals NFL mock draft picks include Francis Mauigoa, David Bailey
2026 NFL Draft projections after NFL free agency for Arizona Cardinals include four different names. Who will the team take with No. 3 overall pick?
This Free Tool Can Predict 30-Year Heart Disease Risk for Younger Adults
In TODAY.com's Expert Tip of the Day, cardiologists advise trying an online calculator that lets younger people find out their 30-year heart disease risk.
Kyler Murray weighing Vikings, backup spots
While Kyler Murray is expected to visit the Minnesota Vikings, the reported favorites for his services, the QB's camp is also weighing backup options.
Health Rounds: Death from dementia on the rise among people with type 2 diabetes
March 11 (Reuters) - In people with type 2 diabetes in the world's richest countries, deaths from cardiovascular disease are declining while mortality from dementia is on the rise, a large analysis ha...