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Results for " ira " 6,595 found 🔀 AI-powered Shuffle

Republican Senate Candidates Avoid Tariffs and Iran War at Trump’s Convention

Four battleground Senate nominees who spoke sidestepped a pair of issues that have posed political challenges, focusing instead on Mr. Trump’s tax law and other topics.

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Sep 9 • 11:36 PM EDT • Politics • nytimes.com
Clutch hits remain buried treasure for White Sox

Chicago wastes two bases-loaded opportunities in a 4-2 loss and drops the series to the Pirates

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Sep 9 • 11:26 PM EDT • Sports • sports.yahoo.com
Oil-bubble research could lead to technological breakthroughs

Binghamton University assistant professor collaborates with Georgia Tech for a $590,000 National Science Foundation grant.

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Sep 9 • 8:00 PM EDT • Science • binghamton.edu
Viral storm video at Milford Farmers' Market prompts community support for impacted businesses
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Sep 9 • 7:17 PM EDT • Business • cbsnews.com
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Flower Mound bakery taunts Trump with viral cookies

Hive Bakery is selling cookies to mark the GOP midterm convention, which runs two nights in Dallas.

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Sep 9 • 7:09 PM EDT • Politics • dallasnews.com
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Andoni Iraola dismisses injury worries over Bradley Barcola

Barcola went off against Atletico on the hour holding his left calf.

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Sep 9 • 6:30 PM EDT • Sports • sports.yahoo.com
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Thieves return stolen item to Fed Hill business after viral social media video

Angeli's Pizzeria posted on social media giving the people responsible for taking their computer system 72 hours to return it

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Sep 9 • 6:14 PM EDT • Business • wbaltv.com
WATCH: Trump says oil prices will come down after midterm elections

President Donald Trump, in an exchange with reporters before traveling to Dallas for the midterm Republican convention, added that he believes Iran will finally relent after the pivotal elections are held in the U.S.

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Sep 9 • 6:08 PM EDT • Politics • pbs.org
iPhone 18 Pro is eSIM-Only in These Countries

Apple has been phasing out the SIM card tray on iPhones, with the latest models relying solely on eSIM technology in select countries. According to Apple, the iPhone 18 Pro and iPhone 18 Pro Max support eSIMs only in these countries and regions: Bahrain Canada Guam Japan Kuwait Mexico Oman Qatar Saudi Arabia United Arab Emirates United States U.S. Virgin Islands iPhone 17 Pro models are eSIM-only in the same countries, so there is no change this year.

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Sep 9 • 5:52 PM EDT • Technology • macrumors.com
NFL Expert Points Rams’ Major Concern Before 2026 Season

The Los Angeles Rams enter the 2026 NFL season with legitimate Super Bowl aspirations, but one weakness could threaten their chances of reaching that goal. The team’s offensive tackle situation has emerged as a major concern, particularly because protecting Matthew Stafford will be essential if Los Angeles wants to make another deep postseason run. The […] The post NFL Expert Points Rams’ Major Concern Before 2026 Season appeared first on Gridiron Heroics.

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Sep 9 • 5:24 PM EDT • Sports • sports.yahoo.com
New Intermountain Health Flight & Ambulance Services base

New Intermountain Health Flight & Ambulance Services base at Intermountain Health St. George Regional Hospital will save response time and enhance patient care

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Sep 9 • 4:48 PM EDT • Health • news.intermountainhealth.org
LIV Golf’s Bankruptcy Road Is Unlike Its Predecessors

The troubled golf entity is looking elsewhere across sports for inspiration.

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Sep 9 • 4:15 PM EDT • Sports • sports.yahoo.com
Sporting CP vs. Galatasaray Live Today: Lineups, How & Where to Watch on TV, Streaming

Sporting CP hosts Galatasaray at the Estádio José Alvalade this Wednesday, Sept. 9, on Matchday 1 of the 2026-27 UEFA Champions League league phase. The Portuguese side is coming off a 2-0 victory over Nacional in its most recent Primeira Liga match. After five matchdays, they sit second in the table with four wins and […] The post Sporting CP vs. Galatasaray Live Today: Lineups, How & Where to Watch on TV, Streaming appeared first on HEAVY.

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Sep 9 • 3:30 PM EDT • Sports • sports.yahoo.com
With AI memes, Trump promotes mythical version of himself as challenges stack up ahead of midterms

In the real world, President Donald Trump is struggling to stop inflation, rout the Iranian government and restore American manufacturing with tariffs. It's a different story in the fantastical vision that he shares with supporters on social media.

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Sep 9 • 3:26 PM EDT • Politics • pbs.org
Valheim 1.0's Steam player count soars to a huge 5-year high, but it's not enough to beat the viral survival game's early access peak

Valheim 1.0 is kickstarting a massive resurgence in the survival game's Steam player count, years after becoming a viral phenomenon.

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Sep 9 • 2:45 PM EDT • Technology • eurogamer.net
Spiraea genome reveals how Rosaceae evolved a key defense hormone

A chromosome-level genome of Chinese spiraea reveals how the rose family conserved and remodeled a major route for producing salicylic acid, a hormone central to plant immunity and environmental stress responses.

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Sep 9 • 1:30 PM EDT • Science • eurekalert.org
Christian singer-songwriter to perform in Hershey: Here’s how to get tickets

The “God of Miracles” singer-songwriter will be at the Giant Center in Hershey in April.

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Sep 9 • 1:20 PM EDT • Entertainment • pennlive.com
DHS: Salvadoran TPS holders ‘retain protection’ despite expiration

Earlier this year, the Trump administration announced it is ending TPS for Salvadorans effective Wednesday

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Sep 9 • 11:56 AM EDT • Politics • spectrumlocalnews.com
Many viral DIY home science experiments don't work, but tjos Alka Seltzer lava lamp does
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Sep 9 • 11:40 AM EDT • Science • cbsnews.com
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Former DINK: My lifestyle changed less than I expected after baby

I feared motherhood came with an expiration date for freedom. Then I had my son and realized my life didn't need to change as much as I had expected.

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Sep 9 • 10:35 AM EDT • Business • businessinsider.com
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FiRa Consortium Appoints Sunil Jogi as President

BEAVERTON, Ore.--(BUSINESS WIRE)--Sep 9, 2026--

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Sep 9 • 8:03 AM EDT • Business • rutlandherald.com
A new strategy enables precise fabrication of nanoporous carbon structures

Nanoporous carbon materials have attracted significant interest for applications in lightweight structural materials, microdevices, and bio-integrated systems due to their low density, chemical stability, electrical conductivity, and tunable mechanical properties. However, existing fabrication approaches often struggle to simultaneously achieve precise patterning, controllable porosity, and desirable mechanical performance. A research team led by Professor Min Qiu at Westlake University has developed a new fabrication strategy, termed Mix-ice lithography (Mix-IL), that enables direct construction of nanoporous carbon structures with tunable pore architectures and complex geometries. The study has been published in Science Bulletin.

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Sep 9 • 8:00 AM EDT • Science • eurekalert.org
Beyond Bottlenecks: The Strategic Future of Mexico Healthcare

Mexico must tackle COFEPRIS delays, USMCA uncertainty, and long payment cycles to build a competitive healthcare industry, writes Deyanira Chiñas.

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Sep 9 • 8:00 AM EDT • Health • mexicobusiness.news
Entertainment District Around Akins Ford Arena Starts to Take Shape

Selling or leasing county-owned property around Akins Ford Arena has always been part of the plan for funding its construction, and the Athens-Clarke County Commission took another step toward that goal last week. The county is putting a parcel known as the Kelley Diversified tract on Willow Street up for sale. The old City of Athens bought the land and built a warehouse in 1970, and for a time it was used for vocational training. The unified government declared it surplus in 2007, but bids came in well below expectations, so it was never sold. However, since then the area between downtown and the North Oconee River has been built up, so the property could be more desirable to developers […]

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Sep 9 • 12:11 AM EDT • Entertainment • flagpole.com
NiteShyft Announces October Launch of AI Business Operating Platform for Small Companies

NiteShyft will open its AI business operating platform to the public in October 2026, following private testing in which AI agents completed more than 2,000 business tasks at a median speed 736 times faster than benchmark estimates, according to company records.Dubai, United Arab Emirates--(Newsfile Corp. - September 8, 2026) - NiteShyft today announced that its business operating platform will open to the public in October 2026, following a private testing period in which the platform executed.

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Sep 8 • 11:12 PM EDT • Business • finance.yahoo.com
Trump’s Ability to Channel Voter Concerns Is Tested as Republicans Gather in Dallas

As Republicans face down tough midterm elections, President Trump has appeared out of step with the party on Iran, the economy and other issues.

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Sep 8 • 9:59 PM EDT • Politics • nytimes.com
Pittsburgh Pirates Slim Playoff Hopes No Longer in Their Hands

The Pittsburgh Pirates' playoff hopes are technically still alive, but they'll need a lot of outside help to make it to the postseason.

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Sep 8 • 8:58 PM EDT • Sports • sports.yahoo.com
A very special milestone for Serhou Guirassy

“I’m very, very happy to have played 100 matches for Dortmund. I didn’t know that at all,” said the 30-year-old striker, who joined BVB from VfB Stuttgart in the summer of 2024. One hundred co...

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Sep 8 • 8:40 PM EDT • Sports • sports.yahoo.com
A Very Special Milestone for Serhou Guirassy

“I’m very, very happy to have played a hundred games for Dortmund - I didn’t even realize that,” said the 30-year-old forward, who joined BVB from VfB Stuttgart in the summer of 2024. 100 comp...

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Sep 8 • 8:30 PM EDT • Sports • sports.yahoo.com
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Oil jumps $1 in early trade after Iran launches missiles at Jordan

Oil prices jumped for the fourth straight session, gaining more than $1 in early trade on Wednesday after Iran launched ​fresh attacks on U.S. military assets in the Gulf ‌as the war between Washington and Tehran continued to spill out across the region.

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Sep 8 • 8:23 PM EDT • Business • reuters.com
Pirates Trying to Find This Balance With Konnor Griffin

The Pittsburgh Pirates need Konnor Griffin in the lineup, while also being mindful that he's still coming back from injury.

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Sep 8 • 8:00 PM EDT • Sports • sports.yahoo.com
18 Sports Commentary – the first day of the school year

ELMIRA, N.Y. (WETM) – It’s time for another special 18 Sport Commentary. On this edition, we discuss the very first day of school in the New York region of The Southern Tier. The first day of school symbolizes much more than just being the first day to go back to the classroom. It’s symbolic of […]

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Sep 8 • 7:09 PM EDT • Sports • sports.yahoo.com
18 Sports Plays of the Week

ELMIRA, N.Y. (WETM) – It’s time for the next edition of the 18 Sports Plays of the Week. (Video Courtesy: Rochester Aquinas and Wellsboro Hornets Hudl, Chris Wilcox) The 18 Sports team showcases the top plays from the past week in the Twin Tiers. Top honors this week include 5 major moments on the high school […]

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Sep 8 • 6:35 PM EDT • Sports • sports.yahoo.com
MAC Challenges Michigan Win, Big Ten Fires Back

The Big Ten has responded after the MAC accused its replay crew of failing to follow proper protocol during Michigan’s miracle win over Western Michigan.

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Sep 8 • 5:58 PM EDT • Sports • sports.yahoo.com
Is Davion Mitchell the Miami Heat's Biggest X-Factor?

Gabe Vincent highlights Davion Mitchell’s offensive impact, but Pelle Larsson could prove even more vital to the Miami Heat's championship aspirations.

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Sep 8 • 5:00 PM EDT • Sports • sports.yahoo.com
US targets multiple Iranian tankers near Kharg Island

The US targeted multiple Iranian tankers near Kharg Island in the Strait of Hormuz on Tuesday, according to two US officials.

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Sep 8 • 4:45 PM EDT • Politics • cnn.com
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Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future

The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.

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Sep 8 • 3:12 PM EDT • Technology • gamefile.news
OpenAI's big math breakthrough claim sparks drama

The math community is heated over questions about credit and AI training data after a mathematician's allegations against OpenAI went viral.

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Sep 8 • 3:00 PM EDT • Business • businessinsider.com
Why Don’t Diamondbacks Streak?

Inspiration. I very much enjoyed Jim McLennan’s The Arizona Diamondbacks Have Not Gone Streaking. I learned that the Diamondbacks have not won 7 consecutive games since 7 September 2017 (a very long time). And I tip my hat to JWinMesa for his comment to that article. A summary is that as measured by Total Streak […]

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Sep 8 • 2:00 PM EDT • Sports • sports.yahoo.com
🚨Confirmed XIs: Dortmund host Villarreal in their European opener

The 2026/27 UEFA Champions League kicks off in style at the mystical Signal Iduna Park. Borussia Dortmund come in as favorites, backed by three straight wins and Serhou Guirassy’s firepower up front...

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Sep 8 • 1:55 PM EDT • Sports • sports.yahoo.com
US issues sweeping sanctions against Iranian airlines, foreign businesses

The Trump administration on Tuesday announced new sanctions against all of Iran’s airlines and nearly a dozen foreign companies doing business with Iran’s Mahan Air, which had earlier been sanction…

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Sep 8 • 1:50 PM EDT • Business • thehill.com
Trump honors 9/11 first responders — and plugs his political priorities

President Donald Trump on Tuesday honored the heroes of the September 11, 2001, terror attacks — but couldn’t resist mentioning the Iran war and communism.

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Sep 8 • 1:48 PM EDT • Politics • cnn.com
Pirates’ historic slump signals better days ahead

Pittsburgh’s offense dropped from first to worst in second half of 2026

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Sep 8 • 1:30 PM EDT • Sports • sports.yahoo.com
Future Leader: Haven Banks, Director of Marketing & Outreach, MiraSol Health

Haven Banks, Director of Marketing & Outreach at MiraSol Health, has been named to the Future Leaders Awards Class of 2026 by Hospice News. To become

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Sep 8 • 1:08 PM EDT • Health • hospicenews.com
Tuesday Morning Politics: State of Iran War; Home Stretch to Midterms

Jonathan Lemire, co-host of Morning Joe on MS NOW, writer for MS NOW and staff writer for The Atlantic, talks about the latest developments in national politics.

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Sep 8 • 12:56 PM EDT • Politics • wnyc.org
SSO to open season with guest conductor

The Southwest Symphony Orchestra (SSO) will present its first concert this season “Inspiration” on Sunday, Sept. 27, at 4 p.m., at Mother McAuley High School, 3737 W. 99th St.

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Sep 8 • 12:39 PM EDT • Entertainment • beverlyreview.net
Meta Removes Iran-Linked Network That Faked American Personas to Sway US Political Debate

The Combat Antisemitism Movement (CAM) welcomes Meta’s recent removal of an Iranian regime-linked network that disguised its origins while seeking to influence American political discourse. Meta disclosed the takedown on Aug. 27 in its H2 2026 Adversarial Threat Report. The network consisted of four Facebook accounts and 31 Instagram accounts linked to actors based in […]

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Sep 8 • 12:04 PM EDT • Politics • combatantisemitism.org
US targets Iran’s airline industry as part of pressure campaign

The Trump administration took sweeping actions against Iran’s airline industry on Tuesday as part of its pressure campaign on Tehran.

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Sep 8 • 12:01 PM EDT • Politics • cnn.com
Names in the News 9-8-26

Appointments and promotions at Constellation Hotels, Emirates, Virgin Atlantic and Hilton

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Sep 8 • 11:23 AM EDT • Business • businesstravelexecutive.com
Norman Gelman, Longtime Montgomery County Political Activist, Dies at 97

Norman Ira Gelman, a longtime Montgomery County political activist, policy analyst, writer and Jewish community leader who spent decades involved in public affairs in the Washington area, died July 20.

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Sep 8 • 10:51 AM EDT • Politics • washingtonjewishweek.com
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD

With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.

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Sep 8 • 10:50 AM EDT • Science • fiercebiotech.com
‘Destiny’ Has Inspired A 10-Year Plan For ‘ARC Raiders’

ARC Raiders has a 10-year content plan and is looking to the 12-year-old, recently killed Destiny franchise for inspiration.

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Sep 8 • 9:37 AM EDT • Technology • forbes.com
California’s political hopefuls remain silent on state’s job losses, unemployment

Dan Walters Commentary: The aspirants for those positions are making all sorts of promises to win voters’ approval. But few, if any, have mentioned a slow-motion menace affecting a fundamental

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Sep 8 • 9:30 AM EDT • Politics • santamariatimes.com
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Elvira joins “R.L. Stine’s Pumpkinhead 2” as mysterious witch — See the first look (exclusive)

The Mistress of the Dark, a.k.a. Cassandra Peterson, will play a character named...Cassandra.

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Sep 8 • 9:00 AM EDT • Entertainment • yahoo.com
Elvira joins ‘R.L. Stine’s Pumpkinhead 2’ as mysterious witch: See the exclusive first look

Elvira joins ‘R.L. Stine’s Pumpkinhead 2’. See the exclusive first look at the Mistress of the Dark as a mysterious witch.

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Sep 8 • 9:00 AM EDT • Entertainment • ew.com
Former Pentagon official analyzes Strait of Hormuz oil threats

Former Pentagon official Brent Sadler discusses rising geopolitical risks including Iran's threats in the Strait of Hormuz, U.S. envoys pushing for Russia-Ukraine peace negotiations and the new Russia-North Korea road bridge.

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Sep 8 • 8:56 AM EDT • Business • foxbusiness.com
Bengals Tuesday Trenches: It begins with Pirates

So it begins.

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Sep 8 • 7:00 AM EDT • Sports • sports.yahoo.com
Huawei heads to trial in US over its business dealings in Iran

Eight years after U.S. prosecutors secretly charged China's Huawei Technologies with defrauding HSBC and other banks over its business with Iran, the case ‌is finally heading for trial.

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Sep 8 • 6:01 AM EDT • Business • reuters.com
Huawei Heads to Trial in US Over Its Business Dealings in Iran

By Karen Freifeld NEW YORK, Sept 8 (Reuters) - Eight years after U.S. prosecutors secretly charged China's ⁠Huawei ⁠Technologies with defrauding HSBC and other banks over ⁠its business with Iran, the case is finally heading for trial. Huawei also faces charges for conspiring to steal trade secrets ...

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Sep 8 • 6:01 AM EDT • Business • usnews.com
Filipe Luís confirms Monaco’s continued Erik Lira pursuit

AS Monaco manager Filipe Luís has said that he will “continue to want Erik Lira in every transfer window”. It comes after the Principality club missed out on the Mexico international this summer....

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Sep 8 • 6:00 AM EDT • Sports • sports.yahoo.com
Alonso thought 'outside the box' against Arsenal

BBC Radio 5 Live's Monday Night Club team have been discussing Chelsea boss Xabi Alonso's "brave" and "fascinating" approach to defending Arsenal's corners. The Spaniard suffered his first defeat as Blues manager on Sunday, as Mikel Arteta's side came from behind to earn a 2-1 win at Emirates Stadium. On Sunday, Chelsea employed a tactic of leaving four players upfield for defensive corners, going man for man in the penalty area.

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Sep 8 • 4:25 AM EDT • Sports • sports.yahoo.com
Exciting forward closing in on Liverpool as major deal agreed

An exciting forward is closing in joining Liverpool's first-team very soon. One thing Andoni Iraola has a shortage of is adequate options at senior level in the no.9 position.With the injury of Hugo E...

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Sep 8 • 3:40 AM EDT • Sports • sports.yahoo.com
Liverpool make Alisson Becker new contract decision after 'talks'

Alisson in action for Liverpool, with Andoni Iraola in a circular inset

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Sep 8 • 3:38 AM EDT • Sports • sports.yahoo.com
Europe has plans for cancer and heart disease – lung health is still waiting

Getting respiratory care right could help patients, ease hospital pressure and cut emissions all at once – but Europe still lacks a plan to make it happen

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Sep 8 • 3:30 AM EDT • Health • euractiv.com
Pereira expects UFC rematch with Gane to happen

UFC star Alex Pereira insists the fight that makes the most sense for him is a rematch against Ciryl Gane.

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Sep 8 • 3:22 AM EDT • Sports • sports.yahoo.com
Reds want long-term Hughes replacement

With Richard Hughes' move to Al-Hilal now confirmed, Liverpool are seeking a new sporting director for the fifth time since 2022. Hughes joined Liverpool in the summer of 2024 and oversaw the appointments of Arne Slot then Andoni Iraola. Mike Gordon, the president of Fenway Sports Group (FSG), is overseeing the process of finding Hughes' replacement, with Liverpool keen to make a swift appointment.

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Sep 8 • 2:54 AM EDT • Sports • sports.yahoo.com
Oil price approaches $100 a barrel after attacks on Saudi oil facilities

Saudi authorities said operations at some energy facilities have been attacked ‌by Yemen’s Iran-aligned Houthis

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Sep 8 • 2:33 AM EDT • Business • theguardian.com
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30 years after her death, Gilda embodies Argentina’s enduring faith in folk saints

Thirty years after Argentine cumbia star Gilda died in a tour bus crash, the beloved singer has become something more to many fans: a miracle-working folk saint.

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Sep 8 • 12:27 AM EDT • Entertainment • seattletimes.com
Military and intelligence officials discuss smaller presence in the Middle East as US looks for another post-9/11 strategy

In offices across the military and in the intelligence community, there have been recent quiet discussions about cutting the number of people and facilities typically stationed in the Middle East if the Trump administration succeeds in ending the Iran conflict, six sources say.

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Sep 8 • 12:01 AM EDT • Politics • cnn.com
Lane Kiffin’s Leaked Halftime Speech to LSU Players Goes Viral

The Lane Kiffin era in Baton Rouge began Saturday night when the LSU Tigers faced the Clemson Tigers in primetime.LSU turned the ball over on its very first possession, which led to a Clemson field goal to open the scoring. However, it was all LSU from that point on.Kiffin’s Viral Halftime SpeechLSU entered halftime with […] The post Lane Kiffin’s Leaked Halftime Speech to LSU Players Goes Viral appeared first on HEAVY.

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Sep 7 • 11:59 PM EDT • Sports • sports.yahoo.com
Duke professor Dan Ariely seeks political office in Israel with Pirate Party

After having an article retracted due to allegations of research fraud, Dan Ariely is taking his efforts elsewhere: Israel. He is running on the Pirate Party slate in the Israeli legislative elections Oct. 27.

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Sep 7 • 11:29 PM EDT • Politics • dukechronicle.com
Pat Fitzgerald Creates New MSU Award After Viral Moment

Pat Fitzgerald found a new way to recognize toughness at Michigan State. He also found one nobody is likely to forget. Fitzgerald introduced a weekly Spartan Warrior honor Monday, with offensive tackle Robert Wright Jr. becoming the first recipient after…

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Sep 7 • 9:36 PM EDT • Sports • sports.yahoo.com
Oil rises as risks of prolonged Mideast conflict heighten supply worries

Oil prices extended ‌gains on Tuesday as risks of a prolonged conflict in the Middle East grew after Iran threatened to retaliate against any new U.S. attacks on its assets, heightening worries over supply disruption.

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Sep 7 • 8:50 PM EDT • Business • reuters.com
Pirates’ Oneil Cruz Hasn’t Skipped a Beat Since Injury

Oneil Cruz has been one of the Pittsburgh Pirates' best hitters since coming off the injured list.

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Sep 7 • 8:41 PM EDT • Sports • sports.yahoo.com
New indoor family entertainment center in Mt. Juliet opens for Labor Day weekend

Good Clean Fun! Family Entertainment Center features arcade games, a pirate themed blacklight mini-golf course, a 7D ride and more. It held its grand opening Saturday.

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Sep 7 • 8:41 PM EDT • Entertainment • newschannel5.com
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Alex Pereira Calls for Ciryl Gane UFC Rematch

UFC superstar Alex Pereira is calling for a rematch against interim UFC heavyweight champion Ciryl Gane for his next fight.Gane defeated Pereira via second-round TKO in the co-main event of UFC Freedom 250 in June to capture the interim heavyweight title.However, the fight was not without controversy, as Gane landed several strikes to the back […] The post Alex Pereira Calls for Ciryl Gane UFC Rematch appeared first on HEAVY.

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Sep 7 • 8:09 PM EDT • Sports • sports.yahoo.com
Michigan QB Depth Chart: Who is Bryce Underwood’s Backup?

Michigan Wolverines quarterback Bryce Underwood pulled off a miracle Saturday night against Western Michigan. Fans know the story by now. Underwood threw a Hail Mary pass out of bounds that seemed to give WMU the upset win, only for the officials to put one second back on the clock. The next pass was on target […] The post Michigan QB Depth Chart: Who is Bryce Underwood’s Backup? appeared first on HEAVY.

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Sep 7 • 8:02 PM EDT • Sports • sports.yahoo.com
The war on Iran’s energy infrastructure creates rising political risk

When Israel targeted Tehran’s oil storage facilities in the initial days of the war launched on Feb. 28, black smoke blanketed the capital and plunged parts of the city into darkness. Roughly ten days later, strikes hit natural gas facilities at the giant South Pars field, key oil refineries, major steel plants, and petrochemical complexes, impacting thousands of workers. These attacks on vital energy and industrial assets revealed a critical dimension of the conflict: compounding an already acute domestic energy...

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Sep 7 • 8:00 PM EDT • Politics • amwaj.media
Health experts track early rise in respiratory illnesses ahead of fall and winter

Labor Day may mark the unofficial end of summer, but respiratory viruses are already making the rounds as doctors look ahead to the fall and winter virus season.

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Sep 7 • 7:39 PM EDT • Health • fox13memphis.com
Naomi Osaka’s Fight With Coach Goes Viral During US Open

Japanese tennis star Naomi Osaka's on-court disagreement with her coach, Tomasz Wiktorowski, catches fans' attention during the 2026 US Open. The post Naomi Osaka’s Fight With Coach Goes Viral During US Open appeared first on HEAVY.

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Sep 7 • 7:00 PM EDT • Sports • sports.yahoo.com
Ahoy, Knesset: Israel’s Pirate Party sets sail with Dan Ariely on its slate

The veteran fringe party filed a 25-person list for the October election, with the behavioral economist and best-selling author taking the No. 3 spot.

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Sep 7 • 6:26 PM EDT • Politics • jpost.com
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Researchers identify new therapeutic target for salt-sensitive hypertension

The researchers discovered that a signaling pathway called AP-1 complex links dietary sodium to immune-driven salt-sensitive hypertension.

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Sep 7 • 3:23 PM EDT • Health • news.vumc.org
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Analysis: Who Are Liverpool's 26/27 UEFA Champions League Opponents?

The Reds will play eight games in the league stages of the Champions League, and this is what you need to know about all the teams Andoni Iraola's side is set to face.

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Sep 7 • 2:57 PM EDT • Sports • sports.yahoo.com
Rise of the far right: can Farage get a boost from AfD’s win in Germany?

Pippa Crerar and Kiran Stacey discuss the rise of the far-right in Germany and how it might affect the UK

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Sep 7 • 2:26 PM EDT • Politics • theguardian.com
Two years after its rocky launch, Civilization 7's first paid expansion Earthrise is on its way - but first comes the atomic age

As the legendary Civilization series celebrates its 35th anniversary, developer Firaxis has unveiled a host of new updates coming to Civilization 7.

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Sep 7 • 1:31 PM EDT • Technology • eurogamer.net
Why scientists are looking to provoke disagreement among AI brain models

When people wanted to create better artificial intelligence, they looked to the brain for inspiration. Now the tables are turning, and researchers are using AI models to better understand the brain. But ...

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Sep 7 • 1:20 PM EDT • Science • medicalxpress.com
Chaney: Mississippians deserve more affordable health insurance options

Over the past year, more than 200,000 Mississippians have left the Affordable Care Act marketplace as the cost of coverage has increased due to the expiration

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Sep 7 • 12:30 PM EDT • Health • supertalk.fm
5 Races to Watch This Fall for Answers to the Biggest Midterm Questions

From Iowa to Michigan to Texas, key contests will offer clues about voters’ views of President Trump, progressive ideas, the war with Iran and more.

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Sep 7 • 12:03 PM EDT • Politics • nytimes.com
Orlando Magic's Biggest X-Factor Next Season

Jalen Suggs holds the key to Orlando's championship aspirations. Success hinges on his ability to anchor a physical defense while recapturing the elite shooting stroke that vanished.

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Sep 7 • 12:00 PM EDT • Sports • sports.yahoo.com
Kurdish Political Prisoner Warisheh Moradi Expresses Solidarity with Grieving Sanandaj Families

Warisheh Moradi, a Kurdish political prisoner held in Evin Prison, expressed her condolences to the families of the victims of the Sanan ...

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Sep 7 • 11:40 AM EDT • Politics • iranwire.com
Fuel prices at record Labor Day high in U.S.

Prices shot up after the U.S. and Israel attacked Iran in February and have not settled down since

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Sep 7 • 11:17 AM EDT • Politics • spectrumlocalnews.com
Washington Nationals Tie MLB Blown Save Record

The Washington Nationals will now look to pull off a miracle over the final 17 regular season games to not own the MLB's blown save record

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Sep 7 • 10:24 AM EDT • Sports • sports.yahoo.com
📸 The weekend’s viral images 🍿

An excess of eccentricities. A look back at the most bewildering and captivating moments from this football weekend.Stratospheric goal in Scottish fourth divisionGriezmann dripping with sweatASSE-MHSC...

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Sep 7 • 9:26 AM EDT • Sports • sports.yahoo.com
Domestic demand drives business sentiment turnaround in South Korea

The overall outlook surpassed the baseline of 100 for the first time since before the US-Iran conflict.

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Sep 7 • 8:24 AM EDT • Business • staffingindustry.com
Could Trump’s Iran trade war threaten Spain’s saffron-infused paella?

US threats to punish Iran’s trade partners could disrupt Spain’s saffron supply, pressuring paella chefs and exporters.

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Sep 7 • 8:00 AM EDT • Business • aljazeera.com
Security Forces Dismantle Terrorist Cells Southeast of Iran

TEHRAN (Tasnim) – Iran’s Intelligence Ministry announced the dismantling of three operational cells affiliated with terrorist Takfiri groups in southeastern Iran, with nine terrorists arrested and three others killed in clashes with security forces.

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Sep 7 • 7:00 AM EDT • Politics • tasnimnews.ir
Iran Dismisses Push to Refer Nuclear File to UNSC

TEHRAN (Tasnim) – Iran’s Foreign Ministry spokesman condemned US and Israeli attempts to pressure the UN nuclear chief and pave the way for referring Iran’s nuclear file to the UN Security Council, warning that Tehran will take necessary measures in response to any such move.

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Sep 7 • 6:34 AM EDT • Politics • tasnimnews.ir
Sid Meier's Civilization VII adds Arc of Tomorrow update and Earthrise expansion

At PAX West, in celebration of the franchise’s 35th anniversary, 2K and Firaxis Games announced new updates for Sid Meier's Civilization VII.

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Sep 7 • 5:37 AM EDT • Technology • gamesbeat.com
The copper peptide trend has gone from creams to injections

Copper peptides are one of the biggest viral trends on social media. People are smearing the electric blue tincture on their face, and even injecting it under the skin. The compound is supposed to deliver flawless and firm skin, promote wound healing and other anti-aging effects. So what's the evidence behind GHK-Cu? NPR's Will Stone reports.

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Sep 7 • 4:43 AM EDT • Science • upr.org
Political Prisoner Kamal Jafari Yazdi Calls for Immediate Peaceful Transfer of Power in Iran

In an open statement addressing deepening economic collapse, escalating public outrage, and the regime’s desperate manoeuvres to retain ...

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Sep 7 • 3:25 AM EDT • Politics • iranwire.com