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Politics could endanger Mississippi’s disaster response in jeopary- Mississippi Today
If FEMA disappears, as the Trump administration has proposed, what happens to your community, especially in Mississippi, after the next disaster, watchdog asks?
Green Mountain Care Board cuts proposed 2027 health insurance increases
Health insurance rates are still going up, but the Green Mountain Care Board has significantly lowered the amount of the increases
CMS announces QualTech event focusing on innovative technology to improve health outcomes
The Centers for Medicare & Medicaid Services yesterday announced the launch of QualTech, a new event created to identify innovative technology that improves health outcomes. CMS is seeking participants from U.S-based teams, academic institutions, nonprofit organizations, private sector companies, industry associations and other stakeholders to propose technology solutions in advance of the event.
Doctors Worry Grant Changes Will Derail Biomedical Science
Proposed OMB grant review changes could shift science funding from peer-reviewed to subject to political whims, impacting drug development and patient care.
300 years of mummies found in ancient Egyptian tomb
At least 20 people and one dog reside in the Theban Necropolis chamber.
WHO/UNICEF report highlights gaps in health facility sanitation
Despite notable gains since 2015, only four in ten facilities meet basic sanitation standards and fewer than six in ten achieve basic environmental cleaning standards such patient rooms and wards, operating theatres, examination and treatment areas, toilets and sanitation facilities, leaving patients and health workers exposed to preventable health risks.
Oregon congresswoman proposes program to support first responder mental health
Salinas’ bipartisan proposal is similar to a 2017 law that provided funding for mental health programs for law enforcement.
UTEP president to propose Texas science foundation
EL PASO, Texas (KTSM) — The University of Texas at El Paso announced that its President, Heather Wilson, will testify to the Texas House of Representatives, proposing new state support for research co...
UTEP president to propose Texas science foundation
EL PASO, Texas (KTSM) — The University of Texas at El Paso announced that its President, Heather Wilson, will testify to the Texas House of Representatives, proposing new state support for research…
Meta heads to trial over alleged social media addiction, risks to children
Attorneys general from California, Colorado, Kentucky and New Jersey allege Meta misled the public about the risks its platforms pose to children.
Apple Seeds Sixth iOS 27 and iPadOS 27 Betas to Developers
Apple today seeded the sixth betas of iOS 27 and iPadOS 27 to developers for testing purposes, with the update coming one week after Apple released the fifth betas. Registered developers can download the betas from the Settings app on the iPhone or iPad by going to the General section and selecting Software Update. iOS 27 introduces Apple's smarter version of Siri, Siri AI.
Profit or purpose? Wrong question
David Mammano explores how Rochester businesses combine profit and purpose to create community impact and sustainable growth.
Mark Cuban and Other Founders Wade Into Wealth Tax Debate
Some entrepreneurs, including Mark Cuban, are publicly worried about the potential fallout from California’s proposal to impose a special billionaire tax.
Burcum: At a packed forum, Faribault charts a course for rural health care
Regarding the proposed Allina-Sutter merger, residents want specifics on their hospital’s future ― not talk of synergies and efficiencies, Jill Burcum writes.
AMC Entertainment Holdings (AMC) Proposes Governance Changes, Is The Rebound Already Priced In?
Governance changes put AMC Entertainment Holdings (AMC) in focus AMC Entertainment Holdings (AMC) has put corporate governance firmly on the agenda, asking shareholders to vote on declassifying its board, expanding stockholder rights, and loosening limits on director numbers at the September 24, 2026 annual meeting. See our latest analysis for AMC Entertainment Holdings. The governance proposals arrive after a sharp rebound in AMC Entertainment Holdings’ share price, with a 30 day share price...
8 Famous Science-Fiction Writers and Actors Who Served
Before creating some of science fiction’s greatest stories, these 8 writers and actors served in the U.S. military.
Willerby Hill mental health unit could replace ageing Hull sites
NHS says a purpose-built facility at Willerby Hill will offer a "modern, therapeutic environment".
Scientists led by UCLA found that permanently shaded parts of pits on the Moon stay near a constant 17°C while the exposed surface swings between 127°C and −173°C — meaning humanity's first permanent lunar address may be underground.
LRO thermal data and UCLA-led modelling show why permanent shade in certain lunar pits can remain near 17°C, while cave habitability still depends on access, structure, air and power.
Health expert breaks down impact of daylight saving bill
Physician Dr. Robert Lahita joins 'Fox Report' to discuss the proposed daylight saving time legislation, addressing the possible health impacts if passed.
California could soon limit social media for kids
California lawmakers are moving forward with proposed laws that address the harmful effects of social media on children, including restrictions on addictive features and the ability for parents and children to sue platforms for damages.
Michael Smolens: Powerlink déjà vu on environment, energy and politics
Another proposed high-voltage transmission line through the desert is hotly disputed, much like one built years ago, but there are differences.
Column: Kyle Larson is My Race Car Hero
Kyle Larson Is the Reason I Keep Going I can’t sleep. I’m sitting here after one of the most ridiculous nights I have ever witnessed in motorsports, and I genuinely don’t know how I’m supposed to go to bed. Because tonight wasn’t just another Kyle Larson performance. It reminded me why I fell in love…
Mark Cuban tells Ro Khanna 'you don't understand business,' threatens investment shift over billionaire tax
Mark Cuban warned Rep. Ro Khanna that California's proposed billionaire tax could drive startup founders out of the state, vowing to avoid investing there.
Europe's heatwaves expose insurance gap as business losses mount
For more than a century, cafes in the Italian city of Padua have welcomed customers for an early evening drink, or aperitivo, encouraging them to sit outside and socialise before dinner.
Are You Really ‘Maxxing’ Your Health? What to Know About 4 Viral Health Hacks
“Maxxing” trends are growing in popularity on social media, but experts say these health hacks, which promote optimizing nutrition, sleep, and fertility, may be ineffective or even pose health risks.
Davies: Board must go
>Continued from front board fit for purpose. The economy and the game in Wales is suffering. It is time now for people to voice their opinions, ex-players, regions, and the clubs and the fans most importantly and say change is needed. “It is up to us to force the changes otherwise this is not going […] The post Davies: Board must go appeared first on The Rugby Paper.
Researchers Find That Waist Size Is a Powerful Indicator of Health Risks
Measuring waist size may be one of the simplest and most effective ways to detect obesity-related health risks, according to a study by Rutgers Health researchers. The study, published in JAMA Network Open, found that combining body mass index (BMI) with waist circumference, or using waist circumference alone, performed as well as a newly proposed obesity definition that incorporates multiple body measurements.
These early career scientists left Boulder’s NCAR. Here’s what they’re doing now
“I suppose I was one of many people who was wondering if I would have this job and this fellowship for much longer, and if there would be a job after,” former NCAR researcher Austin Harris said.
These early career scientists left Boulder’s NCAR. Here’s what they’re doing now
“I suppose I was one of many people who was wondering if I would have this job and this fellowship for much longer, and if there would be a job after,” former NCAR researcher Austin Harris said.
AMC Entertainment Holdings (AMC) Puts Board Declassification And Shareholder Rights To A Vote
AMC Entertainment Holdings (NYSE:AMC) outlines proposed corporate governance changes ahead of its upcoming annual shareholder meeting. The company seeks to declassify its board of directors so all directors stand for election more frequently. Proposals include expanded shareholder rights to act by written consent and to call special meetings. Investors are weighing how the reforms could affect board accountability and shareholder influence at AMC. For readers watching AMC and looking for...
Convention Center hotel hits a roadblock: 'I'll vote against it,' Senate president says
"I'm adamantly opposed to putting anything related to Omni on next week's agenda," Senate President Cameron Henry said. "I will be there, and if it's on the agenda, I will vote against it. The financing isn't in place, and we don't have a deal that's good for the state. I've been talking to the Omni folks, but we need to keep talking to find something that works."
Federal Court Rejects Trump-Vance Administration’s Unlawful Restrictions on Health and Housing Grants
Providence, R.I. — A federal judge today rejected the sweeping and unlawful restrictions the Trump-Vance administration imposed on federal grants administered by the U.S. Departments of Health and…
Google Health Update Lets You Get Rid of the Coach
Google Health was supposed to deliver us into the future of health and fitness tracking. With a refreshed app, Apple Health syncing, and a bundle of other new features, including a Google Health...
EPA sued for approving semiconductor chemicals that may pose health risks
Environmental and community groups sued the Trump administration on Friday over its approval of two chemicals for use in semiconductors despite posing health risks. The Environmental Protection Age…
Life on Earth may have begun twice. A Science Advances study found that bacteria and archaea inherited one ancient genetic code but independently evolved the machinery needed to become free-living cells — leading the researchers to describe it as “one origin of the genetic code, but two origins of life.
The study proposes one inherited genetic system but two independent completions of cellular metabolism, not two unrelated acts of abiogenesis.
My husband is LL Cool J. I wanted a purpose of my own.
Simone I. Smith says building a jewelry company with LL Cool J's support helped her create an identity beyond marriage and motherhood.
Shavon Revel Jr. Made Bold Claim After Cowboys-Rams Practice
The Dallas Cowboys and Los Angeles Rams had a joint practice that gave the teams a chance to face different competition for the first time.That might have exposed something within the Cowboys that might become public knowledge. First, George Pickens and CeeDee Lamb are as good as many believe.One other thing, though, is how good […] The post Shavon Revel Jr. Made Bold Claim After Cowboys-Rams Practice appeared first on HEAVY.
HHS seeks comments on collection of customer feedback for national health information exchange network
The Department of Health and Human Services Aug. 14 released a request for comments through the Office of the National Coordinator for Health IT on a proposed three-year generic clearance to collect routine customer feedback on service delivery and performance related to the Trusted Exchange Framework and Common Agreement.
Former NFL Lineman Jared Odrick Finding 'New Purpose' In Racing
NFL lineman-turned-driver Jared Odrick has found new meaning in life after trading in his cleats for cars.
Aesto Health Data Security Incident Affects Multiple Healthcare Provider Clients
A data breach at Aesto Health, a Birmingham, Alabama-based healthcare technology company, has affected several of its healthcare provider clients. Aesto A security incident at the Alabama healthcare technology company Aesto Health has affected at least 27 of its healthcare provider clients and exposed the protected health information of hundreds of thousands of patients.
Opinion | These A.I. Policies Will Hurt Our Business. We Should Do Them Anyway.
The risks posed by A.I. are too great to forgo any regulation, even for those who stand to gain tremendously from the technology’s rise.
Brazil Explores Retaliatory Options Against New US Tariffs
Brazilian President Luiz Inacio Lula da Silva had previously pledged to invoke the Reciprocity Law if Washington imposed the new duties.
The cruelty of turning Jewish children’s pain into political theater (Opinion)
Parents are justifiably frustrated that it took this long for the Boulder Valley School District to address antisemitism in schools. But Superintendent Anderson has acknowledged the problem and proposed concrete action. The district now has…
Rock Creek Entertainment District is not 'no risk'
Nearly two years ago, Norman was told the proposed University of Oklahoma entertainment district and basketball arena tax TIF represented “no new taxes,” “no risk to the public,” and “no
Kentucky health officials report confirmed measles case, suspect outbreak after additional unconfirmed case reports
The Kentucky Department of Public Health announced Thursday that a case of measles with a high number of community exposers was confirmed in Christian County.
'Fill that gap': Large indoor/outdoor sports pavilion proposed along State St.
A new indoor-outdoor sports venue could come to Highway 44 in Eagle. PSP Holdings has proposed to build the Premier Sports Pavilion on a 6.3-acre site along State St. near Horseshoe Bend Rd., to the east of the St. Luke’s Eagle Medical Plaza. “PSP has identified a market in the rapidly growing communities of Eagle, […]
Trump’s Kennedy Center Board Votes to Put His Name Back on the Building
The proposed inscription tests Judge Christopher Cooper's ruling that only Congress can rename the national memorial.
BREAKING: Netflix to shut down two more game studios
Netflix is sticking with video games but once again reducing the number of studios it owns making games. The streaming giant is closing Los Angeles-based Night School studio, which it acquired in 2021 and plans to close Helsinki-based Moonloot, which was founded in 2022. Just six weeks ago, Night School had released Unhinged, a novel 30-minute first-person horror game, streamable on TVs to Netflix users. The game was hailed by Netflix co-CEO Greg Peters in a call with investors. Six weeks later, Night School is closing. Prior to its Netflix tenure, Night School had developed the award-winning supernatural thriller Oxenfree. A second Oxenfree game followed after the purchase, as well as a mobile game designed to tie in to an episode of the Netflix show Black Mirror. Netflix attributed the studio closures to a prioritization around kids gaming, party games, story-driven fare and games with mainstream hooks, such as a recently released FIFA game. “We see an opportunity to be more focused in our execution, so we are making organizational changes to the business to match those priorities,” a Netflix spokesperson told Game File. Netflix is also cutting jobs from its internal games team. A rep declined to say how many jobs were being lost by these cutbacks. “We are incredibly grateful to the talented colleagues we’re saying goodbye to today. We thank them for all their contributions to Netflix, and wish them the best,” the rep said. Netflix started releasing video games, initially on mobile as a free bonus to subscribers, in 2021. By 2023, Mike Verdu, then the head of Netflix’s game operations, was telling me that the company was committed to growing carefully, as it offered more games and built up internal game studios. At the time, it hadn’t made any gaming job cuts. Since then, Netflix has altered its approach. In 2024, it shut down Team Blue, a start-up studio led by ex-Call of Duty and Halo developers that was exploring making a high-end first-person game for the service. Last October, Netflix shut down another studio, Boss Fight, shortly after Peters praised the team’s Squid Game game to investors. (One of Boss Fight’s main developers now works on the Netflix FIFA game for outside studio Delphi.) And in December, Netflix sold cozy game studio Spry Fox back to its founders. Amid all of this, Netflix has shifted from emphasizing mobile games to offering games through TVs and PCs, via streamed connections, with phones used as controllers. That’s how Night School’s Unhinged worked, along with games such as Boggle and Party Crashers that have collectively helped the Netflix game controller app chart well on mobile app stores. The studio cuts leave Netflix with a central gaming team that works with external developers, and a dedicated first party studio in, Helsinki-based Next Games, which produced many of the company’s couch-centric party games. The move away from having a roster of internal game studios aligns with Netflix’s own approach to shows and movies, which are largely produced externally. The company owns few TV/film production studios of its own. The gaming industry overall is seeing large holders of multiple studios cut back, with Sony, Ubisoft, Embracer, Microsoft and other giants closing or selling off studios. Cuts in California-based studios, where costs often run relatively high, have been particularly acute. Netflix has faced skepticism about its gaming plans for years. The moves today are likely to fuel them, and the company has few upcoming projects to counter the narrative. Among the few hinted, acclaimed independent studio Don’t Nod said last year it was working on a game tied to a major Netflix franchise.
Proposed data center at Battey Business Complex terminated
A proposed data center at the Battey Business Complex on North Division Street is dead according to Rome-Floyd County Development Authority Board Chair Jimmy Byars after Atlas Development ended it's
States Lack Uniform Rules for AI Health Liability
CRS report reveals state law gaps in AI health liability. Discover how early lawsuits expose the need for uniform frameworks. Read the analysis.
AI needs science’s search history
“Actually, that’s where the gold is,” said Alasdair Russell, my graduate school friend who leads a pre-clinical genome editing group at Cambridge. He was talking about the winding road of science that is omitted from published papers. “When you’re discussing how to do the experiment, and why this way is better than another way, and what does the data really mean? I know what it shows, but what does it mean?” At RAAIS 2026, he described how his group has begun logging the twisting path of discovery as it happens, recording the verbal and written exchanges that normally disappear. Ideas become nodes in a living graph: they branch when a meeting produces two plausible experiments, merge when separate lines of evidence converge, and go dark when someone quietly stops pursuing them. In his implementation, one agent scores novelty, while another tries to learn “how scientists think and how they navigate through a complex world of data,” so that high-potential nodes can trigger deeper investigation. As frontier AI labs deploy agents toward scientific discovery, giving AI authentic scientific taste remains a trillion-dollar dilemma. The bottleneck is that the record we have kept for centuries of science might be insufficient to get us there. The experiments that never make the paper Peter Medawar, 1960 Nobel laureate and “father of transplantation,” asked in 1963 whether the scientific paper was a fraud, and answered yes: the form of the paper misrepresents the thinking that produced it. Sixty years on, the diagnosis is unchanged. A paper presents a clean progression from hypothesis to result to conclusion. Lost along the way are the unconventional theories, the abandoned or unaffordable methods, and the underwhelming and inconclusive data. It reads like a browser history with every dead end deleted: the ten open tabs, the four rephrased queries, the wrong turn down a subforum. All scrubbed, leaving one clean path from question to answer as the canonical path. What has changed since then is that the discarded material is now worth something. No high-impact journal wants these artifacts, but raw trial and error is the most likely source of the training data required to develop scientific intuition, or what researchers call taste. Earlier attempts to capture the discards were motivated by scientific integrity. The Journal of Negative Results in Biomedicine launched in 2002 to publish rigorous studies that disputed established models or exposed ineffective treatments. Its archive preserved negative conclusions after they had become papers, rather than the live alternatives and arguments that produced them. BioMed Central closed it in 2017, saying the mission had been served now that other journals publish null results. A less generous reading is that in fifteen years it published around 200 papers because almost nobody wants to read a negative result, let alone write one up when it will not count toward academic tenure. AI models are different. Even an uninteresting negative result can be useful, provided it is labeled. Earlier this year, Anthropic put a version of this to the test. The company pulled 129 decision points from real Claude Code sessions between January and March 2026, showed models the work up to a human detour, and asked what should happen next. Claude Mythos Preview beat the human choice 64% of the time, while Opus 4.5 managed 51%. The comparison was tilted toward the models because Anthropic deliberately chose moments where the human decision had room for improvement. On 127 further scenarios where the human action was already strong, the models improved on it only about 20% of the time. The study was possible because Anthropic’s researchers work inside a tool that logs by default. The reasoning, detours and outcome are produced in the same working environment. Biology has no equivalent. Its reasoning happens in hallways, at benches, in Slack threads and on whiteboards, while the outcome arrives weeks later somewhere else. The record has to emerge from the work itself. Ask scientists to reconstruct it afterwards and we’ll create another polished account. Subscribe A log is not a label Before any of this becomes training data, a negative result has to say what failed. The first paper published in the Journal of Negative Results in Biomedicine examined 234 negative studies across five leading medical journals. Only 30% discussed statistical power, and half clearly defined a primary outcome. Tell a model an experiment failed, without telling it whether the assay was underpowered, a reagent had degraded, or the hypothesis was simply wrong, and it will learn noise with confidence. Decision histories have a second missing label too. When a lab considers five experiments and runs one, only the chosen branch returns an outcome. The other four are experimental counterfactuals. Researchers call this the selective labels problem: the data reveal results only for the actions someone chose to take. Such a record can teach a model to imitate a lab’s taste, but it cannot establish that the taste was good. It also smuggles local constraints into general lessons. A lab that never ran cryo-EM because it did not own a microscope teaches a model that cryo-EM is rarely the right call. Alasdair’s nodes preserve the candidate set, which is the necessary first step. To be useful, each decision record needs six fields: The evidence available at that moment, and nothing that arrived later. The candidates considered, including the ones dismissed in a sentence. For each candidate: the expected result, the confidence attached to it, and the cost in time and money. The route chosen, and the reason. What happened next. How the evidence changed the scientist’s view. These must be timestamped before the outcome, because hindsight turns uncertainty into inevitability. Disagreement also has to survive. Averaging three scientists into one clean rationale reproduces exactly the information loss we are trying to fix. But there is an obvious failure mode here. Once decisions are logged and scored, people log for the record post-facto. Anyone who has watched an electronic lab notebook fill up with retrospective tidying knows how quickly a research tool becomes a compliance exercise. A record that costs a scientist ten minutes of honest reflection per decision is worth far more than one that costs an hour of performance. A publication initiative called Registered Reports offers a useful starting point. Here, researchers submit their rationale, methods and analysis plan for peer review before the data exist, and the journal commits in principle to publish if they follow the approved plan. Nature has now expanded the format across every field it covers. This approach to paper writing timestamps intent before the outcome, but it freezes one plan. A useful search history must also preserve how the plan changed, which alternatives were rejected, when, and on what evidence. Subscribe Run the runner-up Autonomous labs show what happens when decisions and outcomes are connected in a loop. Liverpool’s mobile robotic chemist ran 688 experiments over eight days in a ten-variable formulation space. A batched Bayesian search used each result to choose the next experiments and found photocatalyst mixtures six times more active than the starting formulations. Every completed experiment changed what the system did next. The robot optimized within a goal and search space that humans had already chosen. It did not decide which scientific question mattered. So what this work demonstrates is narrower, but still useful: a search history pays off when the options return standardized outcomes quickly. Open-ended biology is harder because branches can take weeks and the discarded alternatives may never be run. Some exploration therefore has to be bought. Where two branches are plausible and the stakes justify the cost, a lab should sometimes run the runner-up. Otherwise the record captures what today’s scientists usually chose and stays silent on what they systematically overlooked. A funder could ring-fence a small fraction of a grant for the branch not taken, provided that the decision record and the outcome are both deposited. That costs money, but so does having every lab rediscover the same abandoned path. Test whether taste transfers When it comes time to evaluate if our new AI system exhibits taste, the comparison should run across laboratories and fields. At selected decision points in a live research campaign, we should freeze the six fields: the evidence, the candidates, expected results, confidence, costs and the choice made. Experts then rank the options before the outcomes are known, and those outcomes are checked independently later. We could give models one of two diets - papers alone, or papers plus decision histories - and ask them to rank the next experiment on unfamiliar projects. Then, we score information gained per dollar and week, calibration, and how quickly weak branches are abandoned. If histories improve choices only inside the lab that produced them, they amount to useful organizational memory. If they improve choices on unfamiliar problems elsewhere, Alasdair’s group will have captured something science has never managed to write down: a transferable record of taste. Until that happens, a scientific search history is a promising record, not yet a training set.
Proposed changes to NSF proposals
Share your feedback about concerning, proposed, updated changes to National Science Foundation funding guidance. The comment period will close on Aug. 24, 2026, at 11:59 p.m. ET.
New York State Department of Financial Services Introduces Guidance and Proposed Regulation to Strengthen New York’s Surprise Medical Bill Resolution Process
New York State Department of Financial Services (DFS) Acting Superintendent Kaitlin Asrow today issued new guidance to health insurers, health care providers, and independent dispute resolution (“IDR”) entities implementing improvements to the IDR process signed into law by Governor Hochul as a part of her Fiscal Year 2026-2027 (FY27) Budget.
Pennsylvania weighs mental-health focus in health and PE standards
A proposed state update could add mental-health awareness, healthy relationships and help-seeking skills to health and PE instruction.
How could Trump's proposed changes to childhood vaccine policies impact public health?
Ask a Scientist: How Do We Track the Trump Administration’s Attacks on Science?
Introducing a multi-purpose tool for documenting AND fighting attacks on science that affect our health and safety.
Trump's vaccine plan would require millions of individual shots last used decades ago
WASHINGTON (AP) — Public health experts have been quick to condemn an executive order from President Donald Trump aimed at upending childhood vaccinations in the U.S., but the biggest obstacles may be the unprecedented financial and logistical challenges it would impose on parents, health provide...
David Ellison is best argument to block Paramount-Warner Bros. deal
Paramount Skydance Chief Executive David Ellison faces an antitrust lawsuit over his proposed purchase of Warner Bros. Discovery. He recently threatened to move Paramount out of California if the suit is not settled.
Summerville council to revisit proposed downtown entertainment district
SUMMERVILLE, S.C. (WCBD) – Summerville Town Council is expected to take up a proposed outdoor entertainment district during its meeting Thursday evening. Council members are scheduled to hold…
Summerville council to revisit proposed downtown entertainment district
SUMMERVILLE, S.C. (WCBD) – Summerville Town Council is expected to take up a proposed outdoor entertainment district during its meeting Thursday evening. Council members are scheduled to hold a second...
Head Start changes could eliminate important child health and safety standards in Ohio, nationally
Child advocates in Ohio and nationally have said proposed changes to the federal early childhood education program Head Start would be “devastating” and eliminate important health and safety standards for children.
Jackson proposes plan to revitalize Georgia’s historic Black business districts
Legislative leaders indicate Dunleavy’s Alaska LNG bill is doomed as business groups pan it
The governor proposed a 2% corporate income tax on oil and gas companies that currently pay no state income tax, though the gas line project itself would be exempt.
Unearthed interview exposes Dem senator's past support for reparations: 'There is a debt unpaid'
Jon Ossoff said in 2019 he would support reparations legislation, calling slavery a "debt unpaid." His resurfaced comments now raise questions.
Asia-Pacific parliamentarians urge bolder action for universal health coverage, climate resilience and responsible AI
Parliamentarians representing 16 countries from across the Asia-Pacific region concluded the Ninth Meeting of the Asia-Pacific Parliamentarian Forum on Global Health (APPFGH) today, reaffirming their key role in advancing universal health coverage (UHC) amid the risks and opportunities posed by AI and climate change. In adopting the Phnom Penh Communiqué, parliamentarians urged fellow legislators regionwide to strengthen sustainable financing for UHC to widen access to health for all, including the most vulnerable populations; promote responsible governance of AI amid ethical concerns over this fast-evolving technology; and build climate-resilient health systems to anticipate and respond to mounting pressures ranging from rising sea levels in coastal areas to air pollution and other environmental degradation.The National Assembly of Cambodia, with support from Cambodia’s Ministry of Health and the World Health Organization (WHO), hosted the Forum in Phnom Penh from 11 to 13 August 2026 – the first time the Forum has convened in a Mekong country.Parliamentarians urge action to close gaps in accessIn the Communiqué, parliamentarians recognized that at-risk and marginalized groups are the ones most severely affected by gaps in access to health services. These groups include people living in poverty, women and children, persons with disabilities, older people, migrants, refugees, and those in rural, remote or island communities. The Communiqué urges fellow parliamentarians and policy-makers to advocate for laws and policies that support sustainable financing to protect people from financial hardship, with a focus on primary health care, prevention and equity. "The Communiqué is a call to action. It sets out ambitious, concrete measures that deliver meaningful impact on the ground. We are all accountable for advancing universal health coverage and translating our commitments into tangible results. Cambodia is fully committed to advancing UHC, including the promotion of ‘healthy people, prosperous country’ campaign,” said Samdech Maha Rathsapheathika Thipadei Khuon Sudary, President of the National Assembly of the Kingdom of Cambodia.His Excellency Professor Chheang Ra, Minister of Health of the Kingdom of Cambodia, highlighted the need for collaboration beyond the health sector. “Universal health coverage cannot be achieved by the Ministry of Health alone. It requires support, particularly from parliamentarians, across political, legislative, financial, social protection, education, infrastructure, and environmental domains. While each country follows its own path, one factor is universally critical for success: strong governance and leadership. We all believe in this principle, and in our respective political roles, we remain committed to strengthening these key success factors to ensure that no one is left behind.”Promoting responsible AI adoption Parliamentarians acknowledged that, while AI has already demonstrated its ability to improve access to health services and support delivery, careful and ethical governance is necessary to safeguard quality, safety, privacy and public trust. This underscores the importance of parliamentarians in promoting legal and regulatory frameworks addressing liability, records ownership and data governance, while embracing innovation that protects ethical practice.“Without strong governance, safeguards for privacy and data security, sustainable financing, and attention to those most at risk of exclusion, new technologies may widen existing gaps instead of closing them. This is why parliamentarians matter. We pass laws. We approve budgets. We scrutinize government action. We represent communities. We can ask whether health services are reaching rural, remote, ageing, poor, and marginalized populations. We can ask whether innovation is being guided by equity, evidence, and ethics,” said Hon. Man Hee Lee, President of the Asia-Pacific Parliamentarian Forum on Global Health.Building climate-resilient health systemsParliamentarians also reiterated that the climate crisis is a direct threat to people’s health and to achieving UHC more broadly, deepening the same gaps in access already faced by at-risk and marginalized communities. They recognized the need for WHO Member States to ensure sufficient national appropriations and oversight, and for parliamentarians to raise awareness in their constituencies and mobilize local action in building climate-resilient and sustainable health systems.“Universal health coverage, climate change and AI cannot be addressed in isolation. The same communities struggling to access health services today are often the ones most exposed to climate shocks, and most in need of the opportunities AI can offer if this technology is governed responsibly,” said Dr Saia Ma’u Piukala, WHO Regional Director for the Western Pacific. “Having served previously in this Forum myself as a parliamentarian from Tonga, I recognize how the Phnom Penh Communiqué reflects the shared resolve of legislators across the Asia-Pacific region: the laws parliamentarians pass and the budgets they approve help ensure this progress reaches the people who need it most.”As the Forum drew to a close, delegates reflected on what they would carry back to their own parliaments and constituencies.“I wish to share three points here worth carrying home from Phnom Penh: we need to invest in primary health care as the foundation of coverage; we need to remove the barriers that keep people from care, whether financial, geographic or social; and we need to build systems that are inclusive by design, protecting those most at risk of being left behind,” added Hon. Ouch Borith, First Vice-President of the Senate of the Kingdom of Cambodia.###Notes for editors:The Asia-Pacific Parliamentarian Forum on Global Health (APPFGH) is a platform for parliamentarians to exchange ideas, build political will, strengthen capacity and foster collaboration towards sustainable health action. This was the ninth meeting of the APPFGH, with the theme “Universal Health Coverage in the era of Climate Change and Artificial Intelligence”. Target 3.8 of the Sustainable Development Goals calls on countries to achieve universal health coverage, including financial risk protection, access to quality essential health services, and access to safe, effective, quality and affordable essential medicines and vaccines for all. In the Western Pacific, UHC service coverage index (SDG 3.8.1) rose from 63 in 2000 to 81 in 2023 (figures include Indonesia), and roughly one in four people in the Western Pacific have experienced financial hardship (SDG 3.8.2). Progress towards UHC in the Asia-Pacific region remains uneven, with hundreds of millions of people still lacking access to essential health services or facing financial hardship due to health-related expenses. Strengthening the role of parliaments – through legislation, financing and oversight – is central to closing this gap and accelerating progress towards UHC across the region.Parliamentarians participating in APPFGH in Cambodia this week include: Hon. Pehin Dato Adanan YUSOF, Brunei Darussalam; Hon. Rosmawatty ABDUL MUMIN, Brunei Darussalam; Hon. LORK Kheng, Kingdom of Cambodia; Hon. YOS Phanita, Kingdom of Cambodia; Hon. KHOUN Khundy, Kingdom of Cambodia; Hon. HENG Halim, Kingdom of Cambodia; Hon. KHOENG Noupheap, Kingdom of Cambodia; Hon. SENG Nhak, Kingdom of Cambodia; Hon. LY Sukry, Kingdom of Cambodia; Hon. NHOEURN Raden, Kingdom of Cambodia; Hon. Dr Ratu Atonio LALABALAVU, Republic of Fiji; Hon. Vijay NATH, Republic of Fiji; Hon. Man Hee LEE, Republic of Korea; Hon. Dr Jiho CHA, Republic of Korea; Hon. Jonghun BAEK, Republic of Korea; Hon. Youngsuk SEO, Republic of Korea; Hon. Dr Phayvanh KEOPASEUTH, Lao People’s Democratic Republic; Hon. Suhaizan Bin KAIAT, Malaysia; Hon. Dr Perpetua KONMAN, Federated States of Micronesia; Hon. Ganmaa DAVAASAMBUU, Mongolia; Hon. Charmaine SCOTTY, Republic of Naoero; Hon. Vincent Ambance KUMURA, Papua New Guinea; Hon. Dr Edwin CRUZADO, Republic of the Philippines; Hon. AUUAPAAU Mulipola Aloitafua Mulipola, Samoa; Hon. ASIATA TAVUI Tafu Salevao, Samoa; Hon. Dr Alani Petelo TANGITAU, Tonga; Hon. Paul PAOLO, Republic of Vanuatu; Hon. Franklyn Ezra WILLIAM, Republic of Vanuatu.For more information, contact: WHO Regional Office for the Western Pacific: wprocom@who.int National Assembly of the Kingdom of Cambodia (International Relations Department): ir.nacambodia@gmail.com
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AbCellera has reported phase 2 results “beyond even the most aggressive upside scenario” that its CEO dared to consider, boosting the biotech’s chances of challenging Astellas and Bayer for a women’s health market. The phase 2 clinical trial compared ABCL635, an antibody targeting NK3R, to placebo in patients with hot flashes caused by menopause. Investigators enrolled 92 postmenopausal women experiencing a mean of about 10 moderate or severe hot flashes per day. By Week 4, the number of moderate or severe hot flashes had fallen by a mean of 8.8 on ABCL635 and by 3.5 on placebo. That statistically significant, placebo-adjusted reduction of 5.3 hit the trial’s primary endpoint. The level of efficacy also cleared the bar set by existing drugs. While cross-trial comparisons can be misleading, AbCellera CEO Carl Hansen, Ph.D., had seen enough to start hyping the program. “We now view ABCL635 as a potential best-in-class non-hormonal therapy with strong differentiation against approved NK3R competitors across all important dimensions, including efficacy, safety, dosing and convenience,” Hansen said on a Monday morning conference call with investors to discuss the data. “We believe ABCL635 is now a highly de-risked program.” Last week, Hansen used AbCellera’s earnings call to set expectations for readout, with the CEO defining success as a clean safety profile and efficacy comparable to the two approved small molecules. The data vaulted over that bar. Astellas linked (PDF) one of the small molecules, Veozah, to placebo-adjusted reductions in hot flash frequency of 2.1 and 2.6 at Week 4 of its two phase 3 trials. Bayer reported (PDF) placebo-adjusted reductions of 3.04 and 3.29 at Week 4 of pivotal studies for its small molecule, Lynkuet. At 5.3, the placebo-adjusted reduction in AbCellera’s trial comfortably cleared the standard set by the incumbents. Veozah and Lynkuet came to market based on evidence of their ability to reduce the frequency and severity of hot flashes. AbCellera’s phase 2 study covered both endpoints, with the Canadian biotech reporting a mean reduction in severity of 1.4 points at Week 4 on ABCL635, compared to 0.3 points for placebo. Again, the placebo-adjusted result compares favorably to data on Veozah and Lynkuet. Analysts shared Hansen’s enthusiasm for the data. The phase 2 results “firmly validate ABCL635 as a potentially best-in-class treatment,” BMO Capital Markets analysts said in a note to investors Monday. ABCL635’s apparent efficacy edge “is likely attributable to the higher dosing/target engagement the asset is able to reach vs. the oral agents due to its wider therapeutic index,” the analysts added. The analysts, who model $2.3 billion in unadjusted peak sales for ABCL635, flagged the safety profile as another positive of the phase 2 readout. While Veozah carries a boxed warning for liver damage, nobody on ABCL635 in the phase 2 trial had elevated liver enzymes or bilirubin values. If replicated in phase 3, the lack of a liver signal could allow approval without the monitoring requirements imposed on Veozah. Investors appeared equally enthused, sending AbCellera's stock up 32% to $9.21 in premarket trading Monday from a Friday closing price of $6.93. Next, AbCellera will collect the Week 12 data and talk to its advisors about further development. The results open up “a wide variety of possibilities of how we might take this forward into phase 3 studies to truly maximize the value of the asset and make sure that ABCL635 is able to demonstrate its differentiation potential,” Sarah Noonberg, M.D., Ph.D., AbCellera’s chief medical officer, told investors.
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I burned out and quit my career. It led me to a new way of thinking.
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