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Where Penn State ranks on ESPN’s updated Football Power Index

Penn State’s second straight loss saw the program fall off the US LBM Coaches Poll, and now the team is tumbling down the Football Power Index.

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Oct 6 • 6:06 AM EDT • Sports • sports.yahoo.com
Second high school football coach dies unexpectedly at same school

The 31-year-old died last month.

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Oct 6 • 6:02 AM EDT • Sports • sports.yahoo.com
From Secret Health Care Prices to Too Much Information

How a seven-year initiative to make health care pricing info more public has fallen short of expectations

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Oct 6 • 5:41 AM EDT • Health • ldi.upenn.edu
Tuesday ‘Dawg Bites Isn’t Anxious… Yet

Welcome to Tuesday, Bulldog fans! And it’s week 6… the halfway point of the regular season. At this juncture, I believe we all thought we’d know exactly where the 2026 Georgia team stood in the national conversation, because the team would have faced 2 lower division opponents, a rebuilding SEC team, an SEC team that […]

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Oct 6 • 5:30 AM EDT • Sports • sports.yahoo.com
NFL power rankings Week 5: No. 1 spot changes hands for third consecutive week
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Oct 6 • 5:11 AM EDT • Sports • sports.yahoo.com
In Race With U.S., China Struggles to Recruit Foreign A.I. Researchers

China’s booming artificial intelligence sector has given local researchers good reason to remain in the country, but it has yet to lure overseas scientists despite a government push.

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Oct 6 • 5:03 AM EDT • Science • nytimes.com
Ken Paxton’s secret weapon: Ted Cruz

Cruz is boosting Paxton with fundraising and advice as he mulls his own political future.

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Oct 6 • 4:45 AM EDT • Politics • yahoo.com
34+ Amazon Prime Day tech deals: Save over 50% on top products from Apple, Sony, Bose and more

Shop top-rated televisions, headphones, security cameras and more.

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Oct 6 • 3:45 AM EDT • Technology • nbcnews.com
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NFL suspends official Jeff Seeman for two games for swearing at Arizona Cardinals tight end Trey McBride

The NFL suspended two officials for separate incidents on Sunday, including Jeff Seeman after he was caught swearing at Arizonas Trey McBride; watch the second NFL London game of the season between the Jacksonville Jaguars and Philadelphia Eagles at 2.30pm Sunday, live on Sky Sports

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Oct 6 • 3:00 AM EDT • Sports • skysports.com
New WVU Bowl Projection Comes With a Fascinating Twist

The West Virginia Mountaineers have lost consecutive Big 12 games, but one new bowl projection gives fans an interesting reason to keep thinking about what could still be waiting at the end of the season. WVU fell to 3-2 following its 45-42 loss to Iowa State on Oct. 3. Rich Rodriguez’s team is now 0-2 in […] The post New WVU Bowl Projection Comes With a Fascinating Twist appeared first on HEAVY.

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Oct 6 • 12:33 AM EDT • Sports • sports.yahoo.com
Rubio begins three-nation NATO tour in Iceland, which is wary of Trump’s Arctic intentions

U.S. Secretary of State Marco Rubio has begun a three-nation tour of NATO allies with a stop in Iceland.

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Oct 6 • 12:04 AM EDT • Politics • seattletimes.com
Second October 'event' possible with new Macs as the focus

Apple already has an unannounced product reveal expected on October 13 and rumors suggest a second round of releases could occur by the end of the month.

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Oct 5 • 10:45 PM EDT • Technology • appleinsider.com
Zac Robinson’s Offense Fails Tampa Bay Once Again

It was the same story on a different day for the Tampa Bay Buccaneers. The Bucs fell to the Green Bay Packers 17-14 on Sunday, marking. the 10th consecutive one-score game the Bucs have played in, and they’ve lost eight of those games. Tampa Bay is now 0-4 for the first time since 2013, when …

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Oct 5 • 10:42 PM EDT • Sports • sports.yahoo.com
Valleywise Health becomes first Arizona hospital to implement LifeBubble NICU technology

The new technology designed to provide a gentler and more secure way to stabilize umbilical lines in premature and critically ill newborns.

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Oct 5 • 10:16 PM EDT • Health • aha.org
CREO Brings AI, Health, National Defense Into Focus for Cybersecurity Awareness Month

The Center of Excellence in Cybersecurity Research, Education and Outreach is marking Cybersecurity Awareness Month with a speaker series that runs through Oct. 29.

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Oct 5 • 9:55 PM EDT • Health • ncat.edu
Digital Science appoints Charlesworth as strategic sales partner of Altmetric and Dimensions in China’s scholarly publishing sector

AsiaNet 201874

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Oct 5 • 9:45 PM EDT • Science • english.kyodonews.net
Prince George’s County Council votes to advance billion-dollar entertainment venue project

The Sphere concert and entertainment venue planned for National Harbor is another step closer to reality after an vote Monday by the Prince George’s County Council, but unions looking to secure agreements on construction of the project have been left out.

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Oct 5 • 9:30 PM EDT • Entertainment • marylandmatters.org
Reds May Have Stumbled Into a Valuable Piece at the Trade Deadline

By flipping rental Nate Lowe for utility prospect Juan Brito, Cincinnati may have secured a versatile switch-hitter ready to spark the 2027 roster after a blistering debut.

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Oct 5 • 9:20 PM EDT • Sports • sports.yahoo.com
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CNN, MS NOW and Politico make final written effort to convince judge to maintain White House access

Lawyers for CNN, MS NOW and Politico said Monday that the White House had offered no new evidence to support their repeated claims that the news outlets’ reporting endangered national security.

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Oct 5 • 9:18 PM EDT • Politics • cnn.com
RFK Jr. moves to reveal health care costs

HHS Secretary Robert F. Kennedy Jr. announced a new initiative requiring the health care industry to publish clear pricing data for consumers.

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Oct 5 • 8:58 PM EDT • Health • fox10phoenix.com
Chicago Sports Fans Fall Bucket List: Must Do's in the Windy City

Learn what fall sports fan activities you must do when you visit the Windy City of Chicago from basketball to football and even baseball.

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Oct 5 • 8:53 PM EDT • Sports • choosechicago.com
Countries race to provide oral health care for all in 100-Day Sprint across Asia

Twenty Asian countries and areas across the WHO Western Pacific and South-East Asia regions vowed to strengthen essential oral health benefits as part of a “100-Day Sprint” initiative, during the 16th Asian Chief Dental Officers Meeting held from 27 to 29 September in Kota Kinabalu, Malaysia. The meeting marked the midpoint of the 100-day sprint bolstering support for countries to develop essential oral health benefit packages that can be integrated into national universal health coverage plans. Convened by the two WHO regional offices and the Malaysian Ministry of Health as the Secretariat, the meeting brought together national oral health leaders from 20 Asian countries, staff from all levels of WHO, WHO collaborating centres and other development partners. Participating countries and areas included: Bangladesh, Bhutan, Brunei Darussalam, Cambodia, China, Hong Kong (SAR) China, India, Indonesia, Japan, Lao People’s Democratic Republic, Malaysia, Maldives, Mongolia, Nepal, the Philippines, Singapore, Sri Lanka, Thailand, Timor-Leste and Viet Nam. Participants reviewed progress and refined proposals using the WHO Service Package Delivery and Implementation (SPDI) Platform. Countries conducted bottleneck analyses across four key areas: service delivery, workforce, access to essential medicines and health products, and health financing. They identified practical actions to address implementation challenges and refined proposed revisions to their national oral health benefit packages. “There is no health without oral health. Through the 100-Day Sprint, countries are advancing the implementation of the Western Pacific regional implementation plan on oral health and strengthening progress towards universal health coverage,” noted WHO Regional Director for the Western Pacific Dr Saia Ma'u Piukala. Participants identified bottlenecks and proposed workable solutions to strengthen access to essential oral health care through primary health care, sharing experiences and discussing how best to translate policy commitments into feasible and sustainable action at the country level. Malaysian Minister of Health Datuk Seri Dr Dzulkefly Ahmad highlighted the importance of prevention and primary health-care approaches to improve oral health: “Oral diseases can have lifelong consequences, yet many are preventable. By integrating essential oral health care into primary health care and promoting prevention in schools and communities, we can improve oral health across the life course.”The WHO team led by Dr Huong Tran, Director of the Division of Health Promotion, Disease Prevention and Control of the WHO Western Pacific Region and national oral health leads from over 20 Asian countries visited the SK Pekan Putatan School, Sabah for school oral health programme including flouride mouth rinsing. © WHO / V. ChaudharyDr Huong Tran, Director of the Division of Health Promotion, Disease Prevention and Control for the WHO Western Pacific Region, emphasized key collaborative roles WHO can play. “Oral diseases are the most common noncommunicable diseases, yet many can be prevented and treated through essential oral health services delivered at the primary health-care level,” she said. “By sharing experiences and using WHO tools such as the SPDI Platform, countries are accelerating progress towards universal health coverage for oral health.” “Integrating oral health into broader health services is essential for reducing inequities, expanding access and recognizing oral health as an integral component of overall health and well-being. The 100-Day Sprint provides an important opportunity to translate this commitment into practical action and ensure that quality oral health services reach all people, especially those most in need,” said Dr Suman Rijal, Director of the WHO South-East Asia regional Department of Healthier Populations and Noncommunicable Diseases. As host of the meeting, Malaysia showcased ongoing efforts to strengthen oral health care through primary health care and prevention-focused approaches, while providing a platform for countries across the two WHO regions to exchange experiences and accelerate progress towards universal health coverage for oral health. “WHO is encouraged by Malaysia's leadership in addressing the burden of oral diseases and advancing universal health coverage for oral health through practical, country-led action,” said Dr Rabi Abeyasinghe, WHO Representative to Malaysia, Brunei Darussalam and Singapore. Countries will continue to refine and figure costs for national oral health benefits during the remaining sessions of the 100 days. These efforts support implementation of the WHO Global strategy and action plan on oral health 2023–2030, while also helping to expand access to essential oral health services through stronger and more equitable health systems across the WHO Western Pacific and South-East Asia regions.______________For more information, or to arrange media interviews, contact: WHO Regional Office for the Western Pacific: wprocom@who.int WHO Regional Office for South-East Asia: SEMediaRelations@who.int

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Oct 5 • 8:00 PM EDT • Health • who.int
Pennsylvania passes 1,000 measles cases as PA health secretary says CDC is minimizing five measles associated deaths

Pennsylvania Health Secretary Dr. Debra Bogen visited a Pittsburgh pharmacy to raise awareness about respiratory illnesses, including COVID-19 and the flu, while addressing the state's rising measles cases.

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Oct 5 • 7:22 PM EDT • Health • wtae.com
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UW-led optoelectronic center receives second round of funding from the US National Science Foundation

A University of Washington-led center for optoelectronics — technologies that combine light and electronics — brings researchers from 14 universities across the U.S. together with the mission to develop new materials to transform information technology with light. Founded in 2021, NSF IMOD has received a second round of funding from the NSF to continue its work for the next five years.

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Oct 5 • 7:15 PM EDT • Science • newswise.com
Rightlessness after reform? Agrarian conflict and the politics of land in Indonesia

A review of Berenschot et al 2026

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Oct 5 • 7:13 PM EDT • Politics • newmandala.org
Retiring GOP Senator reveals his ‘WTF’ moments during the second Trump term
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Oct 5 • 7:02 PM EDT • Politics • cnn.com
😐 Neutral (0%)
Hadley man had an online business selling radioactive chemicals

Jacob D. Miller had an online business called "Collect the Periodic Table" that he ran out of his home in South Hadley, federal prosecutors said.

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Oct 5 • 6:58 PM EDT • Business • bostonglobe.com
Mike Elko Gives Update On Texas A&M Freshman Linebacker Injury

Mike Elko offered positive news on freshman linebacker Tamarion Watkins as Texas A&M prepares for a major SEC road test against No. 14 Missouri.

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Oct 5 • 6:28 PM EDT • Sports • sports.yahoo.com
CSUN Ranks in Billboard’s 2026 Top Music Business Schools

For the fifth consecutive year, CSUN has earned a place among the nation’s top music business programs.

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Oct 5 • 6:12 PM EDT • Business • newsroom.csun.edu
DHS buys 2 more detention centers in California for $950 million

WASHINGTON — The Department of Homeland Security has purchased two immigrant detention facilities in Adelanto for $950 million, according to the private prison corporation that sold them. The sale by

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Oct 5 • 5:32 PM EDT • Entertainment • thederrick.com
[8-K] KUSTOM ENTERTAINMENT, INC. Reports Material Event

KUSTOM ENTERTAINMENT, INC. (symbol: KUST) is the issuer of record for a Form 8-K filing submitted to the SEC.

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Oct 5 • 5:00 PM EDT • Entertainment • stocktitan.net
New fight over election of new leader of Brooklyn Democrats

This is the second attempt that allies of Bichotte Hermelyn have made to replace leadership.

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Oct 5 • 5:00 PM EDT • Politics • ny1.com
New fight over election of new leader of Brooklyn Democrats

This is the second attempt that allies of Bichotte Hermelyn have made to replace leadership.

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Oct 5 • 5:00 PM EDT • Politics • ny1.com
Viktor Gyokeres Extends Nations League Scoring Record With Romania Goal

Viktor Gyokeres has scored in a seventh consecutive Nations League game, extending the competition record he set for Sweden against Bosnia and Herzegovina.

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Oct 5 • 4:57 PM EDT • Sports • sports.yahoo.com
‘Please get vaccinated,’ state health secretary urges as new COVID-19 vaccines roll out

In the midst of a historic measles outbreak, state and local health officials crammed into the family-owned Hilltop Pharmacy in Allentown on Monday to...

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Oct 5 • 4:45 PM EDT • Health • post-gazette.com
Physicians Committee Applauds New Guidance on Animal Use From the National Cancer Institute

In August, the National Cancer Institute (NCI) at the National Institutes of Health (NIH) published new guidance on grant applications for studies involving animal experiments. This guidance requires researchers to justify their use of animals in the publicly available abstract section of applications and encourages them to use human-based methods.

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Oct 5 • 4:36 PM EDT • Science • pcrm.org
The Googlebook era is here: some first impressions of the hardware and a whole new OS

Today is the day. After months of tracking code commits, dissecting leaks, and getting that unforgettable first taste at Google’s media showcase in New York City, Googlebooks are officially landing...

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Oct 5 • 4:30 PM EDT • Technology • chromeunboxed.com
US says foreign financial institutions doing business with Iran may be sanctioned without notice

WASHINGTON, Oct 5 (Reuters) - The US Treasury Department said on Monday it was alerting foreign financial institutions that continue ‌to do business with Iran or its financial sector that they ‌may be sanctioned by Washington without advance notice. DETAILS: • "Foreign financial institutions continuing to transact with sanctioned ​Iranian financial institutions could be targeted at any time without advance notification and should take immediate action to terminate such activity and relationship

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Oct 5 • 4:29 PM EDT • Business • finance.yahoo.com
US says foreign financial institutions doing business with Iran may be sanctioned without notice

WASHINGTON, Oct 5 (Reuters) - The US Treasury Department said on Monday it was alerting foreign financial institutions that continue to do business with Iran or its financial sector that they may be sanctioned by Washington without advance notice.

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Oct 5 • 4:29 PM EDT • Business • kentucky.com
US says foreign financial institutions doing business with Iran may be sanctioned without notice

The US Treasury Department said on Monday ​it was alerting foreign financial institutions that continue to do business ‌with Iran or its financial sector that they may be sanctioned by Washington without advance notice.

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Oct 5 • 4:25 PM EDT • Business • reuters.com
Zach Bryan breaks Gillette Stadium record in ‘Free Palestine’ shirt

Country singer Zach Bryan broke Gillette Stadium’s all-time attendance record on the second consecutive night he wore a “Free Palestine” T-shirt to perform in Robert Kraft’s Massachusetts venue. “Tonight, Zach

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Oct 5 • 4:14 PM EDT • Entertainment • recorderonline.com
Ted Cruz Says JD Vance’s ‘Political Bomb-Throwing’ Shows He’s ‘Insecure’ Ahead of 2028 Election

While Vice President JD Vance might have been floated as a potential frontrunner for the Republican presidential nomination in the 2028 election, Senator Ted Cruz is doing his part to keep the party’s...

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Oct 5 • 4:10 PM EDT • Politics • yahoo.com
Absentee voting in Maine begins today

Secretary of State Shenna Bellows said that only ballots received by the close of polls on election day are counted, regardless of their postmark. Voters should mail them at least a week before election day.

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Oct 5 • 4:00 PM EDT • Politics • mainepublic.org
Broker consolidation shifts from dealmaking to integration

Years of rapid consolidation in the insurance brokerage sector are giving way to a greater focus on integrating acquired firms and on finding sources of organic growth in a softening market…

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Oct 5 • 3:47 PM EDT • Business • businessinsurance.com
Is This A Healthcare Economy?

This analysis examines recent jobs growth in health care and how it compares to the rest of the economy. Health care employment has grown faster than other sectors of the economy, with jobs in physician offices, hospitals, outpatient care centers, home health, and other settings increasing over the past year even as the rest of the job market plateaued.

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Oct 5 • 3:44 PM EDT • Health • kff.org
Why I Don’t Think Ride Or Die Should Have Been Cancelled (And What Company Should Save It...)

(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) So…I recently came across a Reddit thread, talking about films on streaming, wondering why there are no reliable sources out there for streaming ratings data. Sigh. Honestly, as annoyed as I am that so many still don’t realize that we have streaming ratings, I somewhat get it. Until now, there was such a long delay between when a show or film came to streaming and when we got its viewership data; I understand why people were confused. (But, as you know, this just changed.) Also, even back in the day, how many people knew how well films did on television? Luckily, as a reader, you’re in the know. Okay, on to this week’s issue. I want to take a look at Prime Video cancelling Ride or Die and whether I agree with that decision. Overall, we didn’t have any breakout hits (no TV shows landed over 20 million hours according to Nielsen) but we have a lot of steady performers on the streaming charts. Plus, we’ll look at where $50 million in missing box office dollars went. (Spoiler: straight-to-streaming.) All that, plus new episodes of The Secret Lives of Mormon Wives, Supergirl heads to streaming, a new YA show does well on Netflix, the viewership for the Daily Wire’s $50 million fantasy show, what TV show hit-maker can’t make streaming hits, CD sales, all the flops, bombs and misses, and a whole lot more. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of September 7th to September 13th, 2026. You can find a link to my terminology here.) Subscribe Television - Ride or Die Is a Hit…But It Got Cancelled? What The Data “Says” I hate the phrase “here’s what the data says”, even though sometimes I find myself using it. If data just told us everything, we data folks would be out of a job! Data is often messy, complicated and nuanced. When it comes to strategy, many of the best decisions can’t actually use “data”, since it’s vastly too complicated to model. Anyways, I’ve been singing the praises of Prime Video’s Ride Or Die this summer, a show that did very well for them. And yet…it got cancelled. Now, usually when a show gets cancelled, a bunch of websites say “a hit show got cancelled”... Here’s the thing, though: in this case, they’re right! The data “says” that this show was a hit. Specifically, out of 522 first seasons to make a week on the Nielsen charts since 2020, it’s the 75th biggest. On Amazon, Ride or Die is eighth out of 41 first seasons: That’s top 15th percentile all time, almost exactly, which is my definition of a “hit”! I mean, outside of Reacher, Amazon needed a hit this summer! (Admittedly, Off Campus did well for Amazon in the spring, but Ride or Die performed even better.) So what happened? Why did Amazon cancel one of their rare 2026 bright spots? Well, Deadline reported a reason—which I’ll get to—but I’d break it down into three relevant questions: What is a given streamer’s reasoning? Is that reasoning sound? Could the stated reason not be the real reason? According to Deadline, Amazon felt the show “over-indexed” in middle-aged women. (This was based on leaks from within Amazon.) The logic is this: Amazon already reaches this demographic because of unlimited two-day shipping bundled with Prime, so they don’t really need more shows like this. Now, it’s my job to ask if that’s a good reason, and I’ll be honest, in this case, I don’t think it is. Sure, this show may “over-index” in middle-aged women—I’ll just assume that’s the case here—but I think folks often oversell how important over-indexing actually is. When a show is a “hit”, it isn’t a bit bigger than its rivals; it’s usually multiples bigger. For example, Elle only made the charts for two weeks at 8.3 million hours each. So Ride or Die was 80% bigger in its first two weeks, and likely had a much stronger hold, with its terrific 13 million hours in week three. Ride or Die was nearly three times bigger than Sterling Point through three weeks too. And that means that _Elle, Sterling Point a_nd other Amazon YA shows need to not just over-index a little with younger women (assuming that’s who Amazon prefers over middle-aged women), but massively over-index. Otherwise, more people in that demo (and a bunch more besides) likely watched Ride or Die. (I’ll try to explore this concept more in a future article.) And don’t get me started on how Ride or Die did compared to a certain (very, very popular, possibly the world’s most popular) YouTuber’s reality show…which didn’t make the charts after its first week and likely cost much, much more than Ride or Die. All to say, Amazon-MGM Studios/Prime Video can tell reporters that this show didn’t reach the right audience, but that excuse feels weak to me. So this leads to the third question: could other reasons have come into play? Yes! Renewal or cancellation decisions rarely (I’m tempted to say “never”) boil down to one variable. At its simplest, it’s two things: budget versus viewership. But often factors like critical acclaim, ownership and, yes, personal opinion come into play. In this case, Amazon has a new executive running things, and this show isn’t owned by Amazon-MGM Studios (unlike Elle). And yes, it may not have indexed with the right target viewers, too. Likely all of those factors came into play.1 My guess is ownership ended up mattering most. Amazon doesn’t own Ride or Die. It’s actually produced by another major studio. Fortunately/allegedly, this show is being shopped around. I can think of one brand new CEO who should consider it for one of his two major streamers…especially if he wants to rebuild goodwill in Hollywood. His name is on this list of exec producers of Ride or Die… If David Ellison needs some goodwill—and he does—rescue this female-led show tomorrow and grab some good headlines for a day. The data justifies it. Quick Notes on TV We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… How The Secret Lives of Mormon Wives latest season did on Hulu, post-controversy... Whether Supergirl soared on HBO Max... Why the box office is losing money due to the streamers... The viewership for the Daily Wire’s $50 million fantasy show... Updates on The Gentlemen, Lanterns, Outer Banks, King of the Hill and more... What former hit-maker has three streaming flops in a row... Whether The Mandalorian and Grogu popped in week two... All the flops, bombs and misses... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support. If you want an idea of just how much content you’d get in a full issue, check out this older issue. Coming Soon! Oh man, we’re almost caught up! We just have two more issues, then the streaming Ratings Report will be coming out just two weeks after a TV show premieres! Next issue, I’ll be looking at the first two weeks of the NFL Thursday night games on streaming, a huge new spinoff, Reacher’s Neagly on Prime Video, and the latest edition of Monster: The Lizzie Borden Story on Netflix, the return of Slow Horses on Apple and MobLand (quietly one of their biggest shows) on Paramount+, and Dancing with the Stars on both ABC and Disney+. Plus I’ll take a look at animation for adults in 2026. The week after, a ton of movies are coming to streaming: Toy Story 5 on Disney+, Backrooms on HBO Max, Jackass: Best and Last on Paramount+ and The Breadwinner on Netflix, plus a Unabomber film on Netflix and a romcom on Prime Video. Woody Harrelson and Matthew McConaughey have a show on Apple, along with a game show inspired by Willy Wonka that everyone seems to hate. Long term, some crazy (but hopefully crazy like a fox) IP news. FX ordered a new Sons of Anarchy show from Charlie Hunnam, but it’s not about the biker gang. No, it features the show’s cast playing themselves in a new “meta-thriller”. Huh. And a lot of the cast is coming back. Next, Ryan Gosling is producing a Flintstones movie about a “grown-up Bamm-Bamm Rubble”. Also, huh. This one is in “early development” so we’ll see what happens. Both projects are based on IP, but also seem to have crazy takes on the IP, which I like.

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Oct 5 • 3:42 PM EDT • Entertainment • entertainment.substack.com
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Sen. Tillis says his vote for Hegseth was 'biggest regret of my career' in new book

Republican Sen. Thom Tillis says in a new book that his deciding vote to confirm Defense Secretary Pete Hegseth in January 2025 is the “biggest regret of my career” and that he also “should’ve stopped” Robert F. Kennedy Jr. from becoming Health and Human Services secretary in the early days of President Donald Trump’s second term.

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Oct 5 • 3:40 PM EDT • Politics • pbs.org
🙂 Positive (35%)
Chelsea Duo Nominated For 2026 Golden Boy Award

Two Chelsea stars headline the 2026 Golden Boy awards for a second consecutive season as the Blues hunt for a winner of the award for the first time.

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Oct 5 • 2:58 PM EDT • Sports • sports.yahoo.com
Dead star likely birthed a new planet, in astronomical first

A white dwarf probably created a rare ‘second-generation’ planet.

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Oct 5 • 2:43 PM EDT • Science • popsci.com
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Apple Releases Third iOS 27.2 Beta

Apple today seeded the third beta of an upcoming iOS 27.2 update to developers for testing purposes, with the update coming two weeks after Apple released the second iOS 27.2 beta. Apple also seeded a new iPadOS 27.2 beta. Registered developers can download the beta updates by opting in under Settings > General > Software Update and selecting the iOS 27 developer beta. iOS 27.2 includes Apple's redesigned Health app with new Insight and Longevity tabs.

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Oct 5 • 2:19 PM EDT • Technology • macrumors.com
Ted Cruz Says JD Vance Is ‘Feeling Insecure’ amid ‘Political Bomb-Throwing’ Ahead of 2028 GOP Primary

“In my experience, people engage in political bomb-throwing when they’re feeling insecure,” the Texas Republican said of the vice president over the weekend

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Oct 5 • 2:16 PM EDT • Politics • yahoo.com
'If You Can Keep It': Mental Health And Democracy

A veteran journalist covered the Jan. 6 attacks on the Capitol. That experience got her exploring the connection between stress, trauma, and our political choices.Our mental health might affect our politics. But our politics also definitely affect our mental health.In this edition of “If You Can Keep It,” we examine that intersection.Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.

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Oct 5 • 2:10 PM EDT • Health • npr.org
High-Signal Publisher
Health services may be missing the link between alcohol problems and eating disorders, study suggests

A review led by Bournemouth University researchers has highlighted the extent to which people seeking help for alcohol problems may also be struggling with a second, hidden problem with food and eating. ...

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Oct 5 • 2:00 PM EDT • Health • medicalxpress.com
Five Plays: NC State First Quarter

Louisville lost another football game on Saturday. They also lost another game that they should have won. Penalties had been a major issue for this team, but they replaced that issue with turnovers this time around. But the biggest issue remains, and that issue is blown coverages by the secondary. For the second straight week, […]

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Oct 5 • 1:59 PM EDT • Sports • sports.yahoo.com
Texas AG investigating second health insurer over delayed, denied care

The Texas attorney general's office has launched an investigation into UnitedHealth Group, citing reports of nursing home bribes and revoked coverage.

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Oct 5 • 1:25 PM EDT • Health • dallasnews.com
Senate clears bipartisan bills on aviation worker mental health

Sen. Tammy Duckworth says pilots and other workers need to be able “to take care of themselves without fearing for their job security.”

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Oct 5 • 12:55 PM EDT • Health • safetyandhealthmagazine.com
WindRose Health Network Discloses Data Breach Affecting 33K Individuals

Data breaches have been announced by WindRose Health Network and Advantage Home Health Care in Indiana, Camden-on-Gauley Medical Center in West Virginia, WindRose Health Network in Indiana has reported a data breach affecting more than 33,000 individuals. Data breaches have also been reported by Advantage Home Health Care in Indiana, Camden-on-Gauley Medical Center in West Virginia, and Lakes Region Visiting Nursing Association in New Hampshire.

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Oct 5 • 12:49 PM EDT • Health • hipaajournal.com
Top Iranian official admits dire state of the economy: Report

A top Iranian official reportedly admitted that Iran’s economy is in dire straits due to the war and the U.S. blockade of the country. Mohsen Rezaei, secretary of the Supreme National Security Council and former commander in chief of the Islamic Revolutionary Guard Corps, made the admission Saturday at a high-level government meeting focused on […]

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Oct 5 • 12:37 PM EDT • Politics • coloradopolitics.com
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US services sector activity slows in September; price pressures mount

US services sector activity slowed in September as supply chain strains and rising input prices signal persistent inflation risks into next year.

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Oct 5 • 12:33 PM EDT • Business • virginiabusiness.com
Nutritional countermeasures to spaceflight studied at URI

KINGSTON, R.I. – Oct. 5, 2026 – As humans spend longer periods of time in outer space and venture further from Earth, it’s increasingly important for scientists to learn how varied gravity levels affect muscle function and muscle loss, and how those effects can be counteracted or minimized. Theodoros Pavlidis, a second-year doctoral student who […]

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Oct 5 • 12:19 PM EDT • Health • uri.edu
RSU and USAO partner to create Accelerated Master's Program for computer science students

Rogers State University (RSU) and the University of Science & Arts of Oklahoma (USAO) have partnered together to create an Accelerated Master's Program for comp

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Oct 5 • 12:18 PM EDT • Science • ktul.com
RSU and USAO partner to create Accelerated Master's Program for computer science students

Rogers State University (RSU) and the University of Science & Arts of Oklahoma (USAO) have partnered together to create an Accelerated Master's Program for comp

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Oct 5 • 12:17 PM EDT • Science • fox23.com
ASU designs a statewide pipeline for Arizona's anesthesia workforce

Every surgery, C-section, trauma case and cancer operation in Arizona depends on a clinician administering anesthesia and keeping the patient safe while the surgeon works. The state needs more of these clinicians.As of September, the Arizona State Board of Nursing lists 1,759 certified registered nurse anesthetists, or CRNAs, in the state. In 2023, Arizona was short 732 nurse anesthetists, and the shortage is projected to reach 868 by 2033.

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Oct 5 • 12:04 PM EDT • Health • news.asu.edu
Secret Lair Heads South with Festival in a Box: Atlanta 2026 and Mystery Booster Commander Edition

Bolster your collection with Mystery Booster Commander Edition, a sweet new drop, and cool promos from Festival in a Box: Atlanta 2026!

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Oct 5 • 12:00 PM EDT • Technology • magic.wizards.com
Astronomers discover possible planet born from a dead star’s ashes

A second-generation planet might be orbiting a white dwarf, in an astronomy first, according to new research.

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Oct 5 • 11:58 AM EDT • Science • cnn.com
Former White House press secretary Karoline Leavitt lands her next gig as Fox News contributor

Leavitt follows Kayleigh McEnany, the former press secretary who joined Fox in 2021.

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Oct 5 • 11:33 AM EDT • Politics • pbs.org
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Former Trump press secretary Karoline Leavitt joins Fox News

Karoline Leavitt, the tenacious former Trump White House press secretary, is joining Fox News as a contributor. The network announced Monday that Leavitt, 29, known for her rapid-fire defense of

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Oct 5 • 11:24 AM EDT • Entertainment • thederrick.com
Former press secretary Karoline Leavitt lands her next gig: Fox News contributor

Former White House press secretary Karoline Leavitt is joining Fox News as an on-air contributor starting November 1.

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Oct 5 • 11:14 AM EDT • Politics • news5cleveland.com
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Todd Promenade returns on Saturday, Nov. 7

TODD — The Todd CommUnity Dance organizers are pleased to announce the second Todd Promenade event, featuring an afternoon of square dance calling, flatfoot dance, and playing music for dances

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Oct 5 • 11:00 AM EDT • Entertainment • ashepostandtimes.com
Karoline Leavitt joining Fox News as on-air contributor

Former White House press secretary Karoline Leavitt will become an on-air Fox News contributor next month, weeks after stepping down from her prior role to spend more time focusing on her family.

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Oct 5 • 10:45 AM EDT • Politics • cnn.com
Former Trump press secretary Karoline Leavitt joins Fox News

Leavitt joins a long line of former White House secretaries who have made the jump to TV news punditry.

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Oct 5 • 10:41 AM EDT • Entertainment • latimes.com
Soldiers wounded in Iranian drone strike say military medical system failed them

The attack on the second day of the U.S. war with Iran killed six troops and injured dozens

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Oct 5 • 10:34 AM EDT • Politics • spectrumlocalnews.com
Former press secretary Karoline Leavitt lands her next gig: Fox News contributor

Former White House press secretary Karoline Leavitt is joining Fox News as an on-air contributor starting Nov. 1.

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Oct 5 • 10:19 AM EDT • Politics • ksat.com
Former press secretary Karoline Leavitt lands her next gig: Fox News contributor

Former White House press secretary Karoline Leavitt is joining Fox News as an on-air contributor starting November 1 | WWJ Newsradio 950

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Oct 5 • 10:19 AM EDT • Politics • audacy.com
Senate Unanimously Passes the Health Care Cybersecurity and Resiliency Act

A bipartisan bill that seeks to improve healthcare cybersecurity and resilience has been unanimously passed by the U.S. Senate. The bill - The Health Care The U.S. Senate has voted unanimously to advance the Health Care Cybersecurity and Resiliency Act, which requires more robust cybersecurity measures for healthcare organizations and authorizes grants to help rural and under-resourced providers improve cybersecurity.

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Oct 5 • 10:06 AM EDT • Health • hipaajournal.com
US services sector activity slows in September; price pressures mount

US services sector activity slowed in September, with strong domestic demand stretching supply ‌chains and raising prices paid by businesses for inputs, indicating that inflation could remain high into next year.

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Oct 5 • 10:04 AM EDT • Business • reuters.com
Comcast Business 2026 Cybersecurity Threat Report: 79.3 Billion Events Show AI Pressurizing the Threat Landscape

Comcast Business has released its 2026 Cybersecurity Threat Report, an analysis of 79.3 billion cybersecurity events detected across its cybersecurity custom...

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Oct 5 • 10:00 AM EDT • Business • businesswire.com
Top Athletes: J|medical Brings Excellence in Sports Medicine to Allianz Stadium

On 2 and 3 October, Allianz Stadium hosted the second edition of “Top Athletes: Where Excellence Meets Evidence”, the International Congress promoted by J|medical, which brought together in Turi...

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Oct 5 • 9:56 AM EDT • Sports • sports.yahoo.com
Naples Comprehensive Health Names Danny Hogan Chief Financial Officer

October 5, 2026 – Naples Comprehensive Health (NCH) announced today that Danny Hogan has been named its next Chief Financial Officer. Hogan joined the organization on Oct. 5. Hogan brings extensive health care finance and operational leadership experience to NCH. He currently serves as Chief Financial Officer, Shared Services and Integrated Operations, at Bon Secours […]

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Oct 5 • 9:47 AM EDT • Health • southfloridahospitalnews.com
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ESPN predicts Auburn's remaining schedule after SEC loss to Tennessee

How did Auburn football's 2026 outlook change following its Week 5 loss to Tennessee?

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Oct 5 • 9:09 AM EDT • Sports • sports.yahoo.com
Is CBIZ (CBZ) Outperforming Other Business Services Stocks This Year?

Here is how CBIZ (CBZ) and GigaCloud Technology Inc. (GCT) have performed compared to their sector so far this year.

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Oct 5 • 9:00 AM EDT • Business • finance.yahoo.com
Watch live: RFK Jr., Trump officials unveil health care price transparency push

Health and Human Services Secretary Robert F. Kennedy Jr. and Centers for Medicare and Medicaid Services Administrator Dr. Mehmet Oz will announce new efforts Monday aimed at strengthening health c…

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Oct 5 • 8:55 AM EDT • Health • thehill.com
Eurozone business activity grows at fastest pace in 41 months in September

Private sector growth accelerates as demand improves, while input costs, selling prices rise at fastest rates since May | Anadolu

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Oct 5 • 8:53 AM EDT • Business • aa.com.tr
oasisVRX Expands to the Princeton Area With New Active Entertainment Virtual Reality Destination

/PRNewswire/ -- oasisVRX is expanding with the opening of its second location at Princeton North Shopping Center, 1225 Route 206 in Princeton, New Jersey....

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Oct 5 • 8:43 AM EDT • Entertainment • prnewswire.com
Digital Science appoints Charlesworth as strategic sales partner of Altmetric and Dimensions in China’s scholarly publishing sector

Digital Science has appointed Charlesworth as its strategic sales partner of Altmetric and Dimensions in China’s scholarly publishing sector. This collaboration aims to support the growing demand for research data and information across this rapidly developing market.

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Oct 5 • 8:30 AM EDT • Science • newswise.com
Eagles’ 14-Year NFL Veteran Gets Honest On ‘Overwhelming’ Start

Week 4 against the Los Angeles Rams served as the second game for Zach Ertz’s second stint with the Philadelphia Eagles. It was the first time Ertz donned Eagles green at home in South Philly in years. As expected, there was a lot of love shown to Ertz when he scooped up his first catch […] The post Eagles’ 14-Year NFL Veteran Gets Honest On ‘Overwhelming’ Start appeared first on HEAVY.

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Oct 5 • 8:15 AM EDT • Sports • sports.yahoo.com
Cambridge and London Life Sciences Showcase returns during JPM Healthcare Week 2027

o2h co-discovery has announced that the Cambridge × London Life Sciences Showcase will return for its second edition during J.P. Morgan Healthcare Week 2027 in San Francisco.

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Oct 5 • 8:06 AM EDT • Science • news-medical.net
Hunt Marketing Firm in Oxford Receives Accolade

For the third consecutive year, Hunt Marketing in Oxford has earned a place on the Inc. 5000 list of America’s fastest-growing private companies. Hunt ranked No. 4,009 on the 2026 list. “Being named to the Inc. 5000 list for a third time is meaningful because it validates the growth story we’re building,” said CEO and […]

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Oct 5 • 8:01 AM EDT • Business • deltabusinessjournal.com
Three Preseason Goals For Bulls' First Round Pick Dailyn Swain

To secure his place in Chicago’s future, the versatile rookie must rediscover his offensive aggression, leverage his elite defensive length, and prove he can impact winning beyond scoring.

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Oct 5 • 8:00 AM EDT • Sports • sports.yahoo.com
Collaborating with Canadian Scientists on Marine Carbon Dioxide Removal Research

I first met Dr. Helen Gurney-Smith in fall 2024, when Dr. Shannon Meseck and I drove just beyond the U.S.-Canada border to the St. Andrews Biological Station in New Brunswick. We went there to study larval sea scallop respiration when exposed to near-future temperature and pH. This past winter, Dr.

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Oct 5 • 8:00 AM EDT • Science • fisheries.noaa.gov
Democrats want to change the rules for recall elections. Voters get their say with Prop. 5

Democrats say the recall process has gotten out of hand and they want to drop the 'second question' to replace a politician.

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Oct 5 • 8:00 AM EDT • Politics • calmatters.org
Dan Campbell refuses to talk about Kelvin Sheppard’s job security

Detroit Lions coach Dan Campbell wouldn’t discuss DC Kelvin Sheppard’s job security after another defensive meltdown.

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Oct 5 • 7:30 AM EDT • Sports • sports.yahoo.com
Carlisle boss Elliot proud of squad after hard week

After a five-game winless streak, consecutive away wins have eased some of the pressure on Carlisle head coach Rob Elliot.

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Oct 5 • 7:19 AM EDT • Sports • sports.yahoo.com
Huntsville Honored As ‘Secret Sauce Community’ At Heartland Summit

What’s Huntsville’s “secret sauce?”

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Oct 5 • 7:15 AM EDT • Business • huntsvillebusinessjournal.com
Hurricanes Beat Flyers 3-2 In Overtime With Gostisbehere Heroics

The Carolina Hurricanes survived a scare in Philadelphia, using a former Flyer's power-play goal to secure a 3-2 overtime win.

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Oct 5 • 7:05 AM EDT • Sports • sports.yahoo.com
Physician Assistant Brandon Guth Earns Reid Health’s Advanced Practice Provider of the Year Award

Brandon Guth, PA-C, a physician assistant with Reid Medical Associates, is the second recipient of Reid Health’s Advanced Practice Provider (APP) of the Year Award for his commitment to clinical …

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Oct 5 • 7:00 AM EDT • Health • buildingindiana.com
Cybersecurity portal to fight bad guys open for business: NMFTA

The NMFTA has launched its threat portal, where targets of successful and unsuccessful cyberattacks can share their stories.

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Oct 5 • 7:00 AM EDT • Business • freightwaves.com
Jobs in health care. Jobs for women. The US labour market is segmenting. Chernobyl’s radiation and Lenin’s love of literature.

Thank you for opening your Chartbook email. Elmer Bischoff, Two Figures at the Seashore, 1957 The only really dynamic job-creator in the US economy is health care: The largest crunch has come in Federal government, which has shed 2.7 m jobs. Source: tchouvkov on Twitter Tech is struggling. [ Joey Politano 🏳️‍🌈@JosephPolitano The US tech sector continues bleeding jobs in official data released today—overall, employment decreased by 17k last month and is down 69k over the last year That's nearly as bad as the worst of the 2024 tech-cession, and much worse than the 2022 boom or even pre-2020 norms 12:42 PM · Oct 2, 2026 · 15.2K Views 15 Replies · 47 Reposts · 390 Likes ](https://x.com/JosephPolitano/status/2106001807847940232?s=20) The new jobs are all for women. [ Justin Wolfers@JustinWolfers I'm not sure who saw this coming, but so far nearly all the jobs created during the second Trump administration have gone to women. 1:09 PM · Oct 2, 2026 · 33K Views 70 Replies · 146 Reposts · 644 Likes ](https://x.com/JustinWolfers/status/2106008723533533601?s=20) Meanwhile, real wages are being eaten up by modest over-target inflation. [ Heather Long@byHeatherLong The financial pain is real: Wage growth fell to 3% (y/y) in September. That's the lowest in 5 years. Wage growth: 3% Inflation: ~3.4% Inflation has eaten up all wage gains for the average worker since April. Many people are having to make hard choices about what to buy and what … 1:24 PM · Oct 2, 2026 · 37K Views 24 Replies · 275 Reposts · 533 Likes ](https://x.com/byHeatherLong/status/2106012367712620728?s=20) HEY READERS, THANK YOU for opening the Chartbook email. I hope it brightens your day. I enjoy putting out the newsletter, but tbh, what keeps this flow going is the generosity of those readers who clicked the subscription button. If you are persuaded to click, please consider the annual subscription of $60. It is both better value for you and a much better deal for me, as it involves only one credit card charge. Why feed the payments companies if we don’t have to. Subscribe Elmer Bischoff, Bathers, 1960 Americans are disillusioned with higher ed. For contributing subscribers only. Subscribe Where the Chernobyl radiation went. h/t Simon Kuestenmacher aka simongerman600 How Lenin’s love of literature shaped the Russian Revolution - Tariq Ali This, then, was the intellectual atmosphere in which Lenin came of age. His father, a highly cultured conservative, was the chief inspector of schools in his region and much respected as an educationalist. At home, Shakespeare, Goethe and Pushkin, among others, were read aloud on Sunday afternoons. It was impossible for the Ulyanov family – “Lenin” was a pseudonym adopted to outwit the tsarist secret police – to escape high culture. At high school, Lenin fell in love with Latin. His headteacher had high hopes that he might become a philologist and Latin scholar. History willed otherwise, but Lenin’s passion for Latin, and taste for the classics, never left him. He read Virgil, Ovid, Horace and Juvenal in the original, as well as Roman senatorial orations. He devoured Goethe during his two decades in exile, reading and rereading Faust many times. Lenin put his knowledge of the classics to good use in the time leading up to the October revolution of 1917. In April of that year, he broke with Russian social-democratic orthodoxy and, in a set of radical theses, called for a socialist revolution in Russia. A number of his own close comrades denounced him. In a sharp riposte, Lenin quoted Mephistopheles from Goethe’s masterwork: “Theory, my friend, is grey, but green is the eternal tree of life.” Source: The Guardian Elmer Bischoff, The River, 1953 If you’ve scrolled this far, you know you want to click: Subscribe

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Oct 5 • 6:47 AM EDT • Health • adamtooze.substack.com
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth

Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine

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Oct 5 • 6:44 AM EDT • Science • goldrushcam.com
Ticket Information

The Club has received an allocation of 2285 tickets, including 12 wheelchair bays and a number of tickets for ambulant fans.The wheelchair section is located in the home section of the Red Bull Arena....

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Oct 5 • 6:35 AM EDT • Sports • sports.yahoo.com