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Rashid Shaheed leaves Week 7 with knee injury

Seattle Seahawks wide receiver Rashid Shaheed posted two receptions for just one yard on three targets in Week 7

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Oct 25 • 11:03 PM EDT • Sports • sports.yahoo.com
Shares fall in Asia after a decline on Wall Street, and oil prices fall more than 1%

Shares are mostly lower in Asia after a retreat on Wall Street, while oil prices have fallen more than 1%.

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Oct 25 • 10:44 PM EDT • Business • news4jax.com
Travis Kelce’s Physical Appearance Turns Heads Before Seahawks Game

Kansas City Chiefs star Travis Kelce made waves with his appearance in Seattle before Sunday's game against the Seahawks. The post Travis Kelce’s Physical Appearance Turns Heads Before Seahawks Game appeared first on HEAVY.

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Oct 25 • 10:31 PM EDT • Sports • sports.yahoo.com
Vikings Schedule MRI for Injured Running Back

The Minnesota Vikings stayed perfect on Sunday, but they may have to wait until Monday to learn the cost of the win.

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Oct 25 • 10:29 PM EDT • Sports • sports.yahoo.com
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Yoonha Leaves C9 Entertainment After 14-Year Unpaid Settlement Dispute

Yoonha Leaves C9 Entertainment After 14-Year Unpaid Settlement Dispute Singer Files Lawsuit Over Unpaid Funds, Continues Music Career Independently

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Oct 25 • 10:21 PM EDT • Entertainment • chosun.com
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Mass Effect's Commander Shepard Actors, Destiny Community Help #SaveMassEffect Petition Cross 200,000 Signatures

The #SaveMassEffect movement has picked up even more steam after videos from both Commander Shepard actors – and even posts from the Destiny community – helped its petition reach 200,000 signatures.

ign.com logo
Oct 25 • 10:03 PM EDT • Technology • ign.com
A Healthy Balance Between Rigor and Mental Health

Many students of Irvington High School typically start their own nonprofits, strive to have 4.0 GPAs and more extracurriculars than can be counted on the fingers. This is typically seen as the “key” to accomplishing an acceptance to a prestigious university, creating a rigorous and competitive environment where students tend to prioritize academic excellence over...

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Oct 25 • 9:59 PM EDT • Health • ihsvoice.com
Can the Public Sector Offset Road-Construction Losses?

Hennepin Avenue was a cautionary tale.

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Oct 25 • 9:46 PM EDT • Business • tcbmag.com
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Celtics’ Joe Mazzulla Addresses Growing Tatum-Brown Tension

For years, Boston Celtics fans have wondered whether Jayson Tatum and Jaylen Brown were friends off the basketball court. Following Brown’s recent comments to the media, it’s become clear that even if they were, that isn’t the case anymore.On Sunday, October 25, Celtics’ head coach Joe Mazzulla was asked about Brown’s recent comments regarding Tatum […] The post Celtics’ Joe Mazzulla Addresses Growing Tatum-Brown Tension appeared first on HEAVY.

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Oct 25 • 9:28 PM EDT • Sports • sports.yahoo.com
Dominant Doncic scores 52 as Lakers beat Jazz

Luka Doncic scored a monster 52 points as the Los Angeles Lakers maintained their perfect start to life after LeBron James with a 132-123 defeat of the Utah Jazz.From there Doncic and Reaves were relentless, outscoring the entire Jazz offense in the final quarter between them, as the new-look Lakers moved to a perfect 3-0 start.

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Oct 25 • 9:15 PM EDT • Sports • sports.yahoo.com
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Il Volo celebrates nearly 20 years of musical harmony

Longer than many marriages and most rock bands, the Italian singing trio Il Volo have been together for almost 20 years. They’ve gone from teenagers to 30-somethings while selling more

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Oct 25 • 9:00 PM EDT • Entertainment • floridaweekly.com
How a movement of students brought down Serbia's Vučić

In just under two years the students have succeeded in tearing up 14 years of political dominance under Aleksandar Vučić.

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Oct 25 • 8:31 PM EDT • Politics • yahoo.com
Serbia's student movement: How and why students brought down Vučić

In just under two years the students have succeeded in tearing up 14 years of political dominance under Aleksandar Vučić.

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Oct 25 • 8:31 PM EDT • Politics • bbc.com
JESPY Trivia Friendraiser

Put your trivia skills to the test for a great cause! Join JESPY for a fun-filled Trivia Night on Sunday, November 8, 2026, from 5–8 p.m. at Avenue Pub in Maplewood.Gather your friends, enjoy some...

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Oct 25 • 8:30 PM EDT • Entertainment • tapinto.net
Pokemon Pokopia datamine seemingly leaks full DLC 2 Pokemon lineup

Pokemon Pokopia datamines have revealed a whole bunch of new Pokemon that will most likely be added in the second wave of DLC.

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Oct 25 • 8:18 PM EDT • Technology • nintendoeverything.com
Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing

Peyton Manning is one of the greatest players, if not the greatest, to ever play for the Indianapolis Colts. The former quarterback is one of the most decorated players in American football history. He has won the Super Bowl two times, and is a five-time NFL Most Valuable Player. The Colts have not found the […] The post Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing appeared first on Gridiron Heroics.

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Oct 25 • 8:08 PM EDT • Sports • sports.yahoo.com
Chinese scientists discover “D-rex,” a giant fungus with roots stretching back 65 million years

Scientists have discovered a giant new fungus in China that grows up to 20 inches tall and weighs nearly five pounds, making it the largest known of its kind. Dubbed “D-rex,” its evolutionary lineage appears to have emerged shortly after the dinosaurs went extinct, raising intriguing questions about how that ancient catastrophe may have shaped its evolution.

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Oct 25 • 8:00 PM EDT • Science • sciencedaily.com
Tiny magnetic vortices could help computers work more like your brain

Scientists have filmed tiny magnetic vortices called skyrmions melting out of an organized lattice for the first time, revealing new ways to manipulate these unusual structures. The breakthrough could help make brain-like computers a reality, potentially enabling dramatically smaller and more energy-efficient technology.

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Oct 25 • 8:00 PM EDT • Science • sciencedaily.com
Autism study reveals neural circuit supporting flexible learning

Researchers have identified a brain circuit linked to the flexible formation of memories that may help explain some of the differences in learning associated with autism spectrum disorder.

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Oct 25 • 8:00 PM EDT • Science • science.anu.edu.au
Panera closes in Dillon, Underground Snowboards gets new owners and more business news

Panera Bread has closed its Dillon location less than four years after opening, adding to a growing list of national restaurant chains that have shuttered businesses in the area. The establishment at 257 Dillon Ridge...

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Oct 25 • 8:00 PM EDT • Business • summitdaily.com
Wizards rule out AJ Dybantsa for fourth-straight match

The NBA world will have to wait another night to see AJ Dybantsa's NBA debut.

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Oct 25 • 7:39 PM EDT • Sports • sports.yahoo.com
5 Pocket-Sized EDC for People Who Hate Carrying Bulky Multitools

A multitool can earn its place in your pocket, right up until its weight makes you leave it at home. Pliers, blades, drivers, and openers all need somewhere to go, and those stacked layers of steel add up. If your daily repairs mostly involve opening a package or tightening a loose screw, carrying the entire

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Oct 25 • 7:30 PM EDT • Technology • yankodesign.com
Teddy Roosevelt Erred on Neanderthals

Just recently, paleontologists have found Neanderthal wooden tools (62-40 kya) preserved in stone.

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Oct 25 • 7:28 PM EDT • Science • scienceandculture.com
7 Cars And Trucks That Have Some Of The Worst MPG Ratings Ever

Seven fuel-hungry vehicles, including the Ram TRX, Ferrari Enzo, Bugatti Veyron and Lamborghini LM002, return as little as 5 mpg.

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Oct 25 • 7:25 PM EDT • Technology • jalopnik.com
Vikings just proved why nobody wants to face Minnesota

The Minnesota Vikings have one real strength on their squad.

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Oct 25 • 7:15 PM EDT • Sports • sports.yahoo.com
Aaron Jones will have an MRI on his knee
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Oct 25 • 7:14 PM EDT • Sports • sports.yahoo.com
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Kids say ‘trick-or-treat’ at downtown businesses

SIOUX FALLS, S.D. (KELO) — Kids of all ages walked up and down Phillips Avenue Sunday afternoon dressed up in their Halloween costumes. Some of those costumes featured characters from movies …

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Oct 25 • 7:00 PM EDT • Business • keloland.com
What’s going on with AJ Dybantsa’s ankle injury?

The Washington Wizards have started off playing well this season, and they’ve done so without the No. 1 overall pick. AJ Dybantsa hasn’t made his NBA debut yet as he deals with an ankle injury, and it looks like he’ll have to keep waiting after the latest update on his status, according to Brett Siegel of ClutchPoints. “AJ Dybantsa will remain […] The post What’s going on with AJ Dybantsa’s ankle injury? appeared first on ClutchPoints.

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Oct 25 • 6:53 PM EDT • Sports • sports.yahoo.com
Early voting underway in Michigan

Early voting began Saturday, Oct. 24 in Michigan. County officials say the first day of early voting went well and more than half of mail-in ballots have already been returned.

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Oct 25 • 6:51 PM EDT • Politics • abc12.com
Try This If You Want To Stop Losing Your Roku Remote

Roku remotes have a way of disappearing just when you want to watch something. Before you pull the couch apart again, there's something worth trying.

tech.yahoo.com logo
Oct 25 • 6:47 PM EDT • Entertainment • tech.yahoo.com
Judges skeptical of Trump administration effort for force California to set aside mail ballots

A three-judge US Circuit Court of Appeals panel expressed significant skepticism Sunday over the Justice Department’s desire to inject itself into California’s midterm vote-counting process by forcing election officials to set aside the votes of suspected noncitizens who have been issued mail ballots.

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Oct 25 • 6:38 PM EDT • Politics • cnn.com
TMSM Weekly Recap: Star Wars Super Bowl, Cap Lifts Thor's Hammer, Halloweentown 5 and More

Missed anything? Here are the biggest Disney stories from October 18 to 24, from Star Wars Funday Football and Avengers: Doomsday to Halloweentown 5 and Gideon's new trading cards.

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Oct 25 • 6:24 PM EDT • Entertainment • themainstreetmouse.com
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A new state on the way? More Illinois counties could vote to leave Chicago behind

More than 30 counties have already approved the non-binding measure to leave Illinois

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Oct 25 • 6:06 PM EDT • Politics • yahoo.com
After testing all major mobile browsers, this one finally earned my default spot

Looking beyond Chrome paid off with the best browser experience

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Oct 25 • 6:00 PM EDT • Technology • androidpolice.com
Bengals Shut out in Disastrous First Half vs Ravens

The Cincinnati Bengals are off to a first half they’d like to forget. Cincy trails the Baltimore Ravens 13-0 in Baltimore.The story has been the Cincinnati Bengals’ defense which has been struggling against this Ravens offense.The Ravens got off to a hot start as Zay Flowers took a 48-yard pass to the house from backup […] The post Bengals Shut out in Disastrous First Half vs Ravens appeared first on HEAVY.

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Oct 25 • 5:33 PM EDT • Sports • sports.yahoo.com
Hinge damage suspected to be behind iPhone Duo screen cracks

The cause behind a repeating pattern in the way a very small amount of iPhone Duo screen cracks may have been discovered, with a failing element of the hinge believed to be causing the most damage.

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Oct 25 • 5:28 PM EDT • Technology • appleinsider.com
Oregon State gains ground in AP poll after bye week

The Beavers gained votes in the AP poll, but dropped in the coaches poll.

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Oct 25 • 5:19 PM EDT • Sports • sports.yahoo.com
Volkswagen Bet On Xpeng To Save Its China Business, But Buyers Aren't Showing Up

Volkswagen once dominated China’s automotive market, but the rise of domestic electric vehicle manufacturers has turned its fortunes upside down. Hoping to regain lost ground, the German automaker partnered with Chinese EV specialist Xpeng in ... Read more

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Oct 25 • 5:00 PM EDT • Business • finance.yahoo.com
Here's how Bengals' second half vs Ravens made NFL history

The Cincinnati Bengals became just the 10th team in NFL history to get shut out in the first half and then score 35 points or more in the second half.

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Oct 25 • 4:49 PM EDT • Sports • sports.yahoo.com
Here's how Bengals' second half vs Ravens made NFL history

The Cincinnati Bengals became just the 10th team in NFL history to get shut out in the first half and then score 35 points or more in the second half.

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Oct 25 • 4:49 PM EDT • Sports • sports.yahoo.com
New York Giants' Cam Skattebo Just Saved His Job

New York Giants running back Cam Skattebo saved his job against the Houston Texans.

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Oct 25 • 4:37 PM EDT • Sports • sports.yahoo.com
Ravens surrender 35 unanswered points in stunning loss to Bengals

Baltimore squandered a 13-0 halftime lead as Joe Burrow threw four touchdown passes and Cincinnati handed the Ravens a 35-13 defeat

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Oct 25 • 4:33 PM EDT • Sports • sports.yahoo.com
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Frisco Muslims vote in Texas midterms marked by anti-Islam rhetoric

Texas politicians have campaigned on banning Shariah this cycle. Muslim voters are encouraging their fellow believers to get involved in politics.

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Oct 25 • 4:02 PM EDT • Politics • dallasnews.com
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Bengals blank Ravens in second half, win 35-13
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Oct 25 • 4:01 PM EDT • Sports • sports.yahoo.com
Instant analysis after Bengals wake up, trounce Ravens

Quick notes and takeaways after the Bengals beat the Ravens in Week 7.

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Oct 25 • 3:57 PM EDT • Sports • sports.yahoo.com
Erick All leaves Week 7 game early

Bengals TE Erick All ruled out after suffering a knee injury in Week 7

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Oct 25 • 3:42 PM EDT • Sports • sports.yahoo.com
Barcelona host Real Madrid in anticipated Clásico clash

2026-10-25T20:12:58ZThere have been a few crunching tackles on both sides in the last few minutes and now the benches have taken exception as there is a little coming together in the center of the par...

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Oct 25 • 3:33 PM EDT • Sports • sports.yahoo.com
Rep. Carbajal Meets with Cottage Health’s Head Honchos in Santa Barbara as They Brace for ‘Big Beautiful Bill’ Impacts

Trump’s bill expected to leave close to 40,000 Central Coast residents without health coverage, another 37,000 with higher premiums, and a roughly $40 million initial impact on Cottage.

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Oct 25 • 3:30 PM EDT • Health • independent.com
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The Politics of Heaven ~ The Imaginative Conservative

The key to understanding Thomas More’s generous dedication to the real but limited good he could do on earth is, as Frank Mitjans makes clear, that More’s constant contemplation of God was the source of his boundless care for the souls surrounding him. Thomas More’s Vocation, by Frank Mitjans

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Oct 25 • 3:20 PM EDT • Politics • theimaginativeconservative.org
Cardinals vs. Broncos live updates, analysis, highlights, scoring

We have live updates of the Cardinals-Broncos game in Week 7. Keep up with pregame, in-game and postgame coverage.

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Oct 25 • 3:18 PM EDT • Sports • sports.yahoo.com
Ravens lose standout rookie to injury against Bengals

The Baltimore Ravens have lost a key rookie to injury, forcing another change up front against the Cincinnati Bengals.

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Oct 25 • 2:59 PM EDT • Sports • sports.yahoo.com
Week 7 inactives for Broncos

Broncos have declared seven players inactive for Week 7

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Oct 25 • 2:46 PM EDT • Sports • sports.yahoo.com
‘I love spending time with them’: Lewis Hamilton opens up about Kim Kardashian’s kids

Lewis Hamilton and Kim Kardashian have been one of the most talked-about couples in sports and entertainment this year, but the seven-time Formula 1 world champion has rarely said much about the relat...

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Oct 25 • 2:28 PM EDT • Entertainment • yahoo.com
‘There's a risk we do have a disconnect’: Business on Australian Labor

Chamber of Commerce CEO Andrew McKellar appears to suddenly be everywhere, all at once.

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Oct 25 • 2:15 PM EDT • Business • politico.com
Inside 26-year-old’s club for million-dollar Chattanooga business owners

At 2nd American Restaurant on Thursday night, around 85 entrepreneurs who have scaled their businesses to at least $1 million in annual revenue sat to a family-style meal of beef cheek roast, airline chicken and the restaurant's signature bowl of mashed potatoes.

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Oct 25 • 2:01 PM EDT • Business • timesfreepress.com
Navigating D1 pressure: how student-athletes balance their mental health

Mental health affects everyone, including athletes who have a really good way of hiding it. Research shows that mental health issues affect roughly 39-44% of Division I athletes. Behind game day, good game performance, and navigating life in college, D1 athletes are constantly trying to balance high expectations with their own well-being. It’s not...

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Oct 25 • 1:59 PM EDT • Health • nmsuroundup.com
Scientists Develop a Clever New Way To Kill Cancer Cells From the Inside

Scientists have developed an experimental strategy that exploits a chemical byproduct of cancer cells to produce anticancer drugs directly inside them. Scientists in Japan have developed an experimental method that uses a chemical produced by cancer cells to manufacture anticancer drugs directly inside them. The approach relies on carbon monoxide, a toxic gas that certain

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Oct 25 • 1:45 PM EDT • Science • scitechdaily.com
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine

Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria contracted Ebola.

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Oct 25 • 1:45 PM EDT • Health • seattletimes.com
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine

Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria cont...

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Oct 25 • 1:44 PM EDT • Health • abcnews.com
Knicks Have Clear Advantage Over Magic With Lopsided Injury Report

The New York Knicks look for their first win of the season.

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Oct 25 • 1:36 PM EDT • Sports • sports.yahoo.com
Chris Olave targeted 10 times in Week 7

New Orleans wide receiver Chris Olave went for six receptions for 56 yards on 10 targets in Week 7

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Oct 25 • 1:33 PM EDT • Sports • sports.yahoo.com
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Projections for Cleveland Guardians’ Arbitration Eligible Players

The Cleveland Guardians have several key players arbitration-eligible this offseason.

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Oct 25 • 1:30 PM EDT • Sports • sports.yahoo.com
Sunday Open Thread

There is no Jays news and I’ve got nothing to talk about, so lets have an open thread. We had the second great World Series game in a row last night. I like watching baseball (or any sport) when I have no rooting interest. After a season of caring about every Jays game, I like […]

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Oct 25 • 1:17 PM EDT • Sports • sports.yahoo.com
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How To Build A Cheap Home Server To Save Money On Subscriptions

You can turn an old laptop, a computer, or even a Raspberry Pi into a cheap media server, but it's best to run a Linux distribution for maximum compatibility.

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Oct 25 • 1:17 PM EDT • Technology • bgr.com
Broncos Place Linebacker, Running Back On Injured Reserve

The Denver Broncos have a fluid injury situation, with Tyler Badie and Jonah Elliss being placed on injured reserve.

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Oct 25 • 12:57 PM EDT • Sports • sports.yahoo.com
Saints Lose Defensive Battle in Paris Against Steelers

A very winnable game that a better team would have won.

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Oct 25 • 12:36 PM EDT • Sports • sports.yahoo.com
'Not a one-person job:' Bernardsville explores exit from Bernards Health Department

BERNARDSVILLE - Concerns about costs have led borough officials to consider cutting off decades-long services from the Bernards Township Health Department and switching to the Somerset County Health Department.

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Oct 25 • 12:27 PM EDT • Health • newjerseyhills.com
Bloomington business continues to blossom

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Oct 25 • 12:11 PM EDT • Business • insideindianabusiness.com
😐 Neutral (0%)
Week 7 inactives for Ravens

Baltimore declares five players inactive versus Cincinnati

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Oct 25 • 12:06 PM EDT • Sports • sports.yahoo.com
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The rise and fall of Route 66

Route 66 was one of America's most popular highways, driving business to small towns. But today, the road and its people have been largely forgotten.

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Oct 25 • 12:00 PM EDT • Business • businessinsider.com
Americans have a grief problem we still call a mental health problem

OPINION — Americans have become much better at talking about mental health. We have learned words such as trauma, post-traumatic stress disorder, depression, anxiety, burnout, compassion fatigue and moral injury. That vocabulary matters.

yourvalley.net logo
Oct 25 • 12:00 PM EDT • Health • yourvalley.net
Browns Week 7 inactives: Who's in, who's out?

The Browns are the healthiest they have been in some time as they take on the Titans in Week 7.

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Oct 25 • 11:59 AM EDT • Sports • sports.yahoo.com
Trick-or-treaters descend on Callow Avenue for Calloween

Photos from Charleston Business District's annual Calloween event on Saturday, Oct. 24. ·

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Oct 25 • 11:57 AM EDT • Business • kitsapsun.com
Connections: Law firms hire attorneys for NWA offices

Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...

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Oct 25 • 11:50 AM EDT • Politics • talkbusiness.net
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Connections: Law firms hire attorneys for NWA offices

Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...

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Oct 25 • 11:50 AM EDT • Business • talkbusiness.net
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Scientists Discover a Plant Compound That Could Help Stop Rheumatoid Arthritis Inflammation

Scientists have identified a plant compound that reduced joint swelling and inflammation in rats with experimental arthritis. The discovery offers a potential new direction for rheumatoid arthritis tr...

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Oct 25 • 11:49 AM EDT • Science • yahoo.com
Baylor reportedly fires head coach Dave Aranda, Joe Klanderman to serve as interim
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Oct 25 • 11:47 AM EDT • Sports • sports.yahoo.com
Chivu: “The boys gave everything right to the end”

Cristian Chivu wasn't the only one who couldn't bear to watch Zielinski's decisive penalty. The Inter coach bent over on the touchline, looking away as the midfielder stepped up to take it. When the b...

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Oct 25 • 11:45 AM EDT • Sports • sports.yahoo.com
Baltimore Ravens vs. Cleveland Bengals Week 6 game discussion

Join the discussion about the Ravens’ Week 7 matchup with the Bengals!

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Oct 25 • 11:45 AM EDT • Sports • sports.yahoo.com
How Braves should handle $42 million Jurickson Profar situation

This could be one solution for the Braves.

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Oct 25 • 11:36 AM EDT • Sports • sports.yahoo.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
California election officials frustrated, rattled by DOJ demand to sequester 'noncitizen' ballots

The administration has insisted that immigrants voting is a major problem nationwide, when in fact it is quite rare, as even its own investigations have shown.

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Oct 25 • 11:17 AM EDT • Politics • pbs.org
Robinson, Baker have tough talk about the offense

Robinson, Baker have tough talk about the offense

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Oct 25 • 11:15 AM EDT • Sports • sports.yahoo.com
Their friend died of cervical cancer in 2020. Now, they advocate for women’s health in N.S.

Following the death of their close friend from cervical cancer in 2020, two women in Nova Scotia were left wondering how things might have been different had she been diagnosed earlier. Six years later, they have raised over $4 million to improve technology and infrastructure for women's health.

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Oct 25 • 11:05 AM EDT • Health • cbc.ca
Seattle Mariners Rumors: Zach Neto Gaining Traction as Possible Target

The M's certainly have a need for what Neto can provide.

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Oct 25 • 11:00 AM EDT • Sports • sports.yahoo.com
Postpartum recovery window may play a critical role in maternal aging and long-term health

In many studies, it appears that women who have more children have a higher risk of heart disease and a shorter life span, but this effect is inconsistent across populations and no good explanation for ...

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Oct 25 • 11:00 AM EDT • Health • medicalxpress.com
GeForce Unlocked: Modders Boost RTX 20, RTX 30, and RTX 40 Compute Performance by Up to 2x

NVIDIA's GeForce RTX 30-series and RTX 40-series graphics cards are based on the same dies as their professional-grade GPUs. This means the compute potential of consumer-oriented RTX GPUs is restricted by NVIDIA's firmware stack, but modders have managed to unlock the instruction issuing rate...

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Oct 25 • 10:43 AM EDT • Technology • techpowerup.com
October 7 should have changed Israeli politics, yet we are voting for the same leaders

Israel deserves more than another election between yesterday’s failures. It deserves a new beginning.

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Oct 25 • 10:36 AM EDT • Politics • jpost.com
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Grading Iowa Football's Loss To Minnesota

This may have been Iowa's worst quarterback performance since the dreadful 2023 season.

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Oct 25 • 10:30 AM EDT • Sports • sports.yahoo.com
9 Cool Camping Features Built Into Oliver Travel Trailers (And 3 You Can Add Yourself)

The utility you can get with an Oliver Travel Trailer these days will surely enhance your next camping trip, but there is even more than meets the eye.

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Oct 25 • 10:30 AM EDT • Technology • slashgear.com
Mavericks 'Very, Very Confident' in Rookie PG Behind Kyrie Irving

Spanish sensation Sergio de Larrea shined with 21 points against San Antonio, proving he can anchor the rotation while Dallas carefully manages Kyrie Irving’s heavy workload.

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Oct 25 • 10:29 AM EDT • Sports • sports.yahoo.com
10 Thoughts From Watching Others Sweat It Out

Back during the very lean years of the Ray Goff era in Athens, a certain revered columnist for the Macon Telegraph joked in a weekly prediction column that Georgia would lose to “Open” during its upcoming bye week. Thankfully, those years have passed by, and the outlook for Georgia during open weeks for what is […]

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Oct 25 • 10:28 AM EDT • Sports • sports.yahoo.com
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Can social media bans protect young people’s mental health? Early research suggests that bans aren’t the answer

About 20 countries are looking to ban minors from social media. But bans have not always worked as planned. Here are some other ideas to make platforms safer for kids.

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Oct 25 • 10:01 AM EDT • Health • inquirer.com
17 Celebrity Transformations That Left Fans Doing A Double Take

From Avril Lavigne's “soft makeup era” to JoJo Siwa’s “clean girl” aesthetic, these wild celebrity transformations will leave you gagged.

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Oct 25 • 10:00 AM EDT • Entertainment • yahoo.com
Investment driving growth at NWS Crane

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Oct 25 • 9:53 AM EDT • Business • insideindianabusiness.com
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Fernandes dropped: Man United name team to face Bournemouth

Manchester United have named their team to face Bournemouth in the Premier League, with captain Bruno Fernandes dropped from the side.Fernandes has been named among the substitutes at Old Trafford, in...

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Oct 25 • 9:37 AM EDT • Sports • sports.yahoo.com
r/opensource just banned AI, non-English speakers and more

The opensource subreddit’s new rules against AI have sparked a revolt.

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Oct 25 • 9:25 AM EDT • Technology • theverge.com
Week 7 Early Games Open Thread

The only games I’m really keyed in on are the Steelers and Texans both losing to the NFC team and then decided which team between the Bengals and Ravens are the bigger threat to Denver’s future playoff seeding arrangement. Here are the games we have to watch today before the Denver Broncos take on the […]

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Oct 25 • 9:25 AM EDT • Sports • sports.yahoo.com
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Will there be VAR for Fleetwood Town vs Arsenal?

The EFL have confirmed the match official appointments for the upcoming round of League Cup fixtures, including Arsenal’s trip away to Fleetwood Town.Photo by George Wood/Getty ImagesThe EFL have co...

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Oct 25 • 9:05 AM EDT • Sports • sports.yahoo.com
Petition to "Save Mass Effect" reaches over 170k signatures as fans plan billboard outside EA HQ

The Mass Effect community is not going down without a fight

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Oct 25 • 9:00 AM EDT • Technology • windowscentral.com