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US soccer legend Landon Donovan opens up on mental health struggles, redefining success
American soccer legend Landon Donovan opened up about mental health struggles and reconfiguring what success meant to him. He releases "Landon: A Memoir" this week.
Eye of Terror – New rules for Defilers, Mutilators, and Kravek Morne
See the new datasheets now.
Oil prices rise after Trump issues ultimatum and Iran threatens to close the Strait of Hormuz indefinitely
Oil prices rose Sunday after President Donald Trump threatened to “obliterate” Iran’s power plants if the Strait of Hormuz is not reopened by Monday evening.
Phillies pitcher Daniel Robert stable after second medical emergency in six months
Daniel Robert suffered a cardiac event Sunday — the second in six months — but was stable after his defibrillator activated
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
California sheriff seizes 650,000 ballots in defiance of state officials over election count dispute
Riverside County Sheriff Chad Bianco seized over 650,000 ballots to probe alleged excess votes in California's Proposition 50 special election.
Chivas hold off Monterrey’s comeback to get another win
Chivas defeated Monterrey by a 3-0 score in match defined by the last play of the match.
'Heartbreaking' - fighter pay debate laid bare at UFC London
The debate around fighter pay reemerges at UFC London amid some career-defining performances on the undercard.
Dad’s Donuts, a popular Colorado Springs donut business, announces indefinite closure
Dad’s Donuts, a popular Colorado Springs donut business, announced their indefinite closure Saturday.
'They most definitely misled me' | Macon business owner frustrated after Bibb leaders deny alcohol license
'They most definitely misled me' | Macon business owner frustrated after Bibb leaders deny alcohol license
Microsoft is ending the Windows Update nightmare — and letting you pause them indefinitely
Pause updates “for as long as you need.”
Why Wall Street is scouting college sports stars
Banks have realised the potential from tapping in to tomorrow’s elite - and by definition wealthy - athletes
Unilever Has $40 Billion in Tasty M&A Options
Options have value. And it’s become clear this week that Fernando Fernandez has more than one when it comes to setting a new course for Unilever Plc’s food business, owner of Hellmann’s mayo and Knorr stock cubes. How the consumer giant’s still relatively new chief executive officer plays his hand will likely define his tenure.
Trump faces legacy-defining dilemmas in Iran
The question is no longer whether President Donald Trump has lost control of the narrative of his new war in Iran. It’s whether he’s lost control of the war itself.
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Temple Health Appoints Robert A. Winn, MD, as Cancer Center Director for Fox Chase Cancer Center
Temple Health today announced the appointment of Robert A. Winn, MD, as the next Cancer Center Director for Fox Chase Cancer Center, marking a defining moment that will shape the future of one of the nation’s leading National Cancer Institute-designated Comprehensive Cancer Centers.
Be counted among the Capital Region’s top private companies
Each year, Business Report ranks the Top 100 Private Companies in the Capital Region — one of our most anticipated and widely read features. It’s the definitive look at the companies driving growth, investment and job creation across our market. If your company is privately held and headquartered in the Capital Region, we want to […]
3M to create a leading fire and safety business; acquires Madison Fire & Rescue and combines with Scott Safety
/PRNewswire/ -- 3M (NYSE: MMM) announced today that it has entered into a definitive agreement to acquire Madison Fire & Rescue, in partnership with Bain...
Snowmass considers defining new ‘business district’ for Draw Site, among other updates
Snowmass Town Council might consider a new business district after it was proposed Monday as a way to include small businesses in funding and priority housing for the Draw Site housing project.
8 things you need to do in the first 90 days of launching your consulting business
The early days of an entrepreneurial endeavor will define how the business is received as well as its trajectory.
NASCAR driver Daniel Dye suspended for David Malukas comments
The Kaulig Racing driver will be suspended indefinitely for the second time in the last four years for comments he made about an IndyCar driver.
Allina Health to join Sutter Health in $26B proposed merger
Sutter Health and Minneapolis-based Allina Health unveiled plans to join and form a 39-hospital, $26 billion revenue nonprofit health system. | The cross-regional proposed deal would create a 39-hospital nonprofit system and is expected to close before the end of the year, pending a definitive agreement and regulatory approvals.
Mastercard to Acquire BVNK to Connect On-Chain Payments and Fiat Rails
Mastercard today announced a definitive agreement to acquire BVNK, a leader in stablecoin infrastructure.
Samsung finally responds to complaints about the Galaxy S26 Ultra's headline feature, but the explanation ...
The feature is definitely not as perfect as you would expect.
Chelsea vs PSG – Match preview and team news
Chelsea welcome Paris Saint-Germain to Stamford Bridge tonight, needing a miracle to overturn a daunting three-goal deficit against the Champions League holders.The Blues arrive following a bruising 5...
Plagued by early deficits, Wild turn page to meet Blackhawks
A three-game winless streak has done little to compromise the Minnesota Wild's solid playoff positioning.
UEFA Champions League expert predictions, picks: Can Chelsea, Manchester City or Tottenham stage a comeback?
Elsewhere in the round of 16, Liverpool have a one-goal deficit to overturn, while Arsenal and Newcastle are tied with Leverkusen and Barcelona 1-1
Sports gambling was supposed to create new revenue. Instead it's damaging college scholarships
Tennessee's sports gambling tax revenue exceeds $100 million but the state's Lottery-funded scholarship program faces an $80 million deficit.
Chinese scientists create clock so precise it could redefine second
Optical clock measures time using light emitted by electrons transitioning between energy levels
Africa’s Business Aviation Rebirth
Africa's business aviation sector has lived under the weight of a stubborn global stereotype: a continent defined by ageing aircraft, fragmented regulation and limited economic prosperity.
Paula Doress-Worters, Who Redefined Women’s Health, Dies at 87
Paula Doress-Worters, the mother and activist who opened the door to once-taboo conversations about women’s health in America, has died at 87. Paula was a member of the Boston Women’s Health Book Collective, a group of young women who got together to assemble the groundbreaking manual later known as “Our Bodies, Ourselves,” that dove-into subjects like sexuality, birth control, abortion and post-partum depression. Sunday TODAY’s Willie Geist remembers a life well lived.
Jodi's Journal: Business anniversary meets AI arrival
As we mark nine years in business, we thank you so much for supporting us! In today's column, Jodi details the theme that appears ready to define the next nine years.
Marjorie Taylor Greene Was Never Fringe
The Georgia congresswoman is out of office. Her conspiracies continue to define her party.
Politics: Iowa nonpartisan group predicts bigger budget shortfall than expected
Iowa will likely operate on a near-$1.3 billion budget deficit over the next fiscal year, according to the latest report from state officials.
Penguins overcome another multigoal deficit to win in Utah
SALT LAKE CITY — For almost 35 minutes Saturday, it was shaping up to be a very bad night for the Penguins. The Islanders and Blue Jackets both won,...
Two weeks of war: Inside Trump’s risky decision to attack Iran—and the scramble to contain the fallout
Two weeks in, the Trump administration is no closer to settling on a defined strategy for finishing a conflict that has grown only more complicated and unwieldy by the day, according to interviews with more than a half-dozen people familiar with the internal deliberations.
A 'defining moment' as Health and Human Services budget fails in the senate
The Health and Human Services maintenance budget failed to pass the senate, making it the first budget bill of the session to be sent back to the committee. One
Country singer Colter Wall cancels tour, admits he is ‘mentally unwell’
Country singer Colter Wall cancels his remaining 2026 tour dates and is taking an indefinite break from live performances to focus on his mental health and well-being.
Country music star cancels tour and goes on indefinite hiatus: ‘I am mentally unwell’
The 30-year-old made the announcement on social media.
Torrent Come From Behind To Beat First Place Boston
The last place Seattle Torrent beat the first place Boston Fleet erasing a pair of deficits to snap a four game losing streak.
UCF basketball takeaways: March Madness bid secured with Cincinnati win?
The UCF Knights erased an eight-point deficit with just over two minutes to play and beat Cincinnati in overtime Wednesday.
'Montana Plan' to prohibit corporate spending in politics green lit for signature gathering
After constitutional measure was found legally deficient, group submitted statutory initiative instead
In Texas, Democrats discover the power of the ‘nice guy’ candidate
In a political era defined by nasty personal insults and a race to emulate the worst elements of Trump’s broken character, the Democrats performing best are doing so by focusing on the values that …
Hornets rally for 103-101 victory over the Trail Blazers
Brandon Miller had 21 points and eight rebounds, LaMelo Ball had 12 of his 14 points in the fourth quarter and the Charlotte Hornets overcame a 19-point deficit to beat the Portland Trail Blazers 103-101 on Tuesday night. Kon Knueppel added 15 points and five rebounds for the Hornets, who got back to . at 33-33.
Barzal scores OT winner to cap rally, and Islanders edge Blues 4-3
Mathew Barzal scored in overtime to cap the New York Islanders' rally from a three-goal deficit for a 4-3 win over the St. Louis Blues on Tuesday night. In addition to his goal at 2:11 of the extra period, Barzal had two assists. Calum Ritchie had a goal and an assist and Jean-Gabriel Pageau and Bo Horvat also scored for the Islanders.
These Paralympians are redefining how Para athletes are portrayed. Here's how.
Increasing visibility for Para athletes is central to Culxtured’s mission. The collective also works to redefine how Para athletes are portrayed.
Testing Apple's 2026 16-inch MacBook Pro, M5 Max, and its new "performance" cores
M5 Pro Max's "performance" CPU cores definitely aren't just rebranded E-cores.
EY Consumer Beverage Survey: New consumer research finds health-led choices, generational changes and digital discovery are redefining beverage expectations
The EY organization today released findings from its Consumer Beverage Survey, uncovering three major forces – health, digital engagement and generation shifts – that are reshaping beverage choice and consumption behavior. The study, based on a survey of more than 2,500 consumers across the US and Brazil, explores how these evolving preferences are redefining what people expect from beverages today, and what they will demand tomorrow.
Women’s sports are ‘at risk’ due to growing deficits. Here’s how the University of Utah plans to solve the problem.
Facing mounting deficits, the U. believes private equity is the best way to ensure the future of women’s sports at the university.
Controlled Thermal Resources and Plum Acquisition Corp. IV Announce Definitive Business Combination Agreement to Advance U.S. Critical Minerals and Energy
As one of America’s largest and most advanced geothermal power and critical minerals projects, the transaction is expected to enable Controlled Thermal Resources to advance its Hell’s Kitchen Project and commence Stage 1 construction.Transaction values Controlled Thermal Resources at a pro forma enterprise value of approximately $4.7 billion. IMPERIAL, Calif., March 09, 2026 (GLOBE NEWSWIRE) -- Controlled Thermal Resources Holdings Inc. (“CTR” or the “Company”), an emerging leader in U.S. critic
Universal Health Services, Inc. to Acquire Talkspace, Inc.
/PRNewswire/ -- Universal Health Services, Inc. (NYSE: UHS) announced today that it has entered into a definitive agreement to acquire Talkspace, Inc. (NASDAQ:...
Universal Health Services, Inc. to Acquire Talkspace, Inc.
Universal Health Services, Inc. (NYSE: UHS) announced today that it has entered into a definitive agreement to acquire Talkspace, Inc. (NASDAQ: TALK) for $5.25 per share. The enterprise value for the transaction is approximately $835 million, which UHS intends to finance with borrowings pursuant to its existing revolving credit facility.
'It's a very unique biological specimen': The scientists using menstrual blood to diagnose diseases
From diagnosing endometriosis and cervical cancer to diabetes, vitamin D deficiency, and pollution exposure, here's what menstrual blood can reveal about your health.
A wartime presidency defined by Trump’s unique political style
President Trump is recasting the role of wartime leader in his image, breaking from generations of practice as he attacks his domestic enemies and revels in memes.
Is Sphere Entertainment (SPHR) Quietly Redefining Its Business Model With the Las Vegas Sphere?
In recent months, Sphere Entertainment’s Las Vegas Sphere venue has seen strong consumer demand for its immersive “The Wizard of Oz” production, alongside expanding concert residencies and original films that are increasing venue utilization. This operational momentum is also encouraging discussions for additional Sphere venues in the U.S. and overseas, while attracting greater institutional interest such as Citigroup’s sizeable stake increase. With this backdrop of “Wizard of Oz”-driven...
Is Sphere Entertainment (SPHR) Quietly Redefining Its Business Model With the Las Vegas Sphere?
In recent months, Sphere Entertainment’s Las Vegas Sphere venue has seen strong consumer demand for its immersive “The Wizard of Oz” production, alongside expanding concert residencies and original films that are increasing venue utilization. This operational momentum is also encouraging discussions for additional Sphere venues in the U.S. and overseas, while attracting greater institutional interest such as Citigroup’s sizeable stake increase. With this backdrop of “Wizard of Oz”-driven...
From the publisher: Business leaders are channeling CSR values into innovative models
Across the state, companies are redefining what success looks like. Profit remains essential. Growth matters. But more leaders are asking a broader question, What impact are we having on our employees, our communities and the environment we all share?
10 Modern Video Games That Redefined or Created Their Genres
These are the video games that changed the way we play. Literally.
Public school teacher redefines success as she homeschools her kids
As a former public school teacher, I was surprised by what homeschooling my own kids taught me about learning beyond grades and test scores.
Raven-Symoné collapses in hysterics after learning lyrics she's being quizzed on are from her own song
Raven-Symoné collapsed in hysterics after learning that the lyrics she was being quizzed on in a game on her podcast were from her own song: 'This is definitely somebody white.'
After week of war and political upheaval, Trump remains defiant as ever
In the last week, Trump has instigated or been forced to navigate a stunning cascade of political threats, but has remained defiant, sounding more unbothered than embattled.
Maxx Crosby's heavy heart farewell by Raiders teammates: "Legend!! Leader!!”
Maxx Crosby confirmed the blockbuster deal with a definitive Instagram farewell.
California whiz kid’s science experiment draws FBI probe: ‘Surprising situation’
“This is definitely a surprising situation,” he said. “I don’t think anybody expects to have the federal authorities knock on their door.”
30 years and 1,000 games later, Beth Mowins and Debbie Antonelli define women's basketball
It started with a game at Penn State in 1996. Now, ESPN's Debbie Antonelli and Beth Mowins have been calling women's college basketball for 30 years.
Carbon emissions now more than double the planetary boundary, analysis finds
Earth is not infinite. Pollution beyond certain levels threatens the climate and ecosystems. To prevent this, scientists have proposed planetary boundaries, defining the safe operating limits of the Earth ...
Community Health Systems Announces Definitive Agreement to Sell Four Arkansas Hospitals to Freeman Health System
Community Health Systems, Inc. (NYSE: CYH) announced today that a subsidiary of the Company has signed a definitive agreement to sell substantially all of th...
Letter: Moore and Ristow demand higher travel and entertainment budgets to attend conferences | Los Gatan
At Los Gatos’ annual priority-setting session, Mayor Moore and Vice Mayor Ristow demanded higher travel and entertainment budgets to fund boondoggle conferences while the Town Manager forecasts upcoming multimillion-dollar operating deficits with no relief in sight. It’s another example of failed Council fiscal leadership, which could cause painful service and staff reductions. Moore and Ristow […]
What’s the Best Month for Sports?
Our definitive ranking of the best months to be a sports fan, from the highs of April (NBA playoffs! The Masters!) to the lows of August (baseball’s snooziest stretch).
‘Rooster’ review: Stellar Steve Carell ensures HBO comedy makes the grade
The new HBO comedy, premiering March 8, plays like the TV equivalent of a beach read: sturdy, often silly, yet still most defined by how it plays it safe.
"We don't want to mislead players" - Control Resonant devs confirm Jesse Faden won't be playable, there's no parry, and it's definitely not a Soulslike
Remedy recently shared more details on its upcoming sequel, Control Resonant.
Tesla robotaxis: 5 numbers, stats that will define the EV-maker's business
New research from Bank of America says robotaxis now account for more than half the company's valuation.
Expanding Access to Small Business Financing
Forward Financing is redefining small business financing, helping owners unlock capital while supporting a more inclusive economy.
Redefining Gold: Joy, Alignment, And Winning In Business
What does it really mean to win gold? Shelley Zalis redefines success, where joy, alignment, and values matter as much as results in business and leadership.
Civility, Federalism, and the Future of American Politics
In a week that could easily have been defined by division, the penultimate session of the 2026 NGA Winter Meeting offered something increasingly rare in American public life: two politicians, from opposite ends of the political spectrum speaking candidly about friendship, shared purpose, and the urgent need to rebuild trust in democratic institutions. Moderated by Laura Collins, Director of the […]
From Alec Pierce to Tyreek Hill: Ranking the wide receivers who could define 2026 NFL free agency
George Pickens, the projected top free agent WR, received the franchise tag.
Experts warn new graduate student loan limits could hurt health care pipeline
The U.S. Department of Education is weighing public feedback on a narrowed definition of who is considered a \
Homologous recombination deficiency and hemizygosity drive resistance in breast cancer
Nature - Germline and somatic interactions define actionable genomic patterns driving acquired therapy resistance in breast cancer.
Super Puff Politics: The Hidden Divide Behind the Brands We Wear
One writer reflects on the fashion trends that become identity-defining on our small campus.
Proactiv Entertainment
New branding and redefined values strengthen the company's global position in the live entertainment industry
Jim Hanson: Those who say the Iran mission is undefined are just 'playing politics'
Former U.S. Army Special Forces Jim Hanson dissects the purpose of the Iranian conflict on 'Jesse Watters Primetime.'
UT Health East Texas Upgrades Life-Saving Capabilities with New LIFEPAK 35 Monitors and LUCAS CPR Devices
Tyler, Texas (February 27, 2026) — UT Health East Texas EMS is proud to announce the addition of new LIFEPAK 35 cardiac monitor/defibrillators and LUCAS Chest Compression System devices to its frontline ambulances, further strengthening the department’s commitment to delivering advanced, high-quality care to the community. The LIFEPAK 35 represents the latest generation of cardiac […]
Alysa Liu's Advice to Parents Whose Kids Want to Quit Sports: EXCLUSIVE
"Trying new things will definitely give you a different outcome."
Conexeu Sciences Appoints Jean-Romain (JR) Falconnet as Head of Business Development & Licensing
Reno, Nevada--(Newsfile Corp. - March 2, 2026) - Conexeu Sciences Inc. ("Conexeu" or the "Company"), a biotechnology innovator redefining regenerative medicine through a next-generation extracellular matrix platform, is pleased to announce Jean-Romain (JR) Falconnet as Head of Business Development & Licensing.In his role at Conexeu, JR will lead business development, licensing strategy, and strategic partnerships—supporting the company's growth roadmap and expanding opportunities to bring...
URI Political Science Professor Skip Mark discusses the definition and measurement of atrocities
Professor Mark recently published a peice in The Conversation titled, “Atrocities take place in democratic nations as well as autocratic ones – our database has logged them all.” The engaging and accessible story discusses how to define, measure, track, and address atrocities around the world and in the US. Link to the story: https://theconversation.com/atrocities-take-place-in-democratic-nations-as-well-as-autocratic-ones-our-database-has-logged-them-all-272879
Neogen Announces Sale of Genomics Business to Zoetis
LANSING, Mich., March 02, 2026--Neogen Corporation (NASDAQ: NEOG), an innovative leader in food safety solutions, announced today it has entered into a definitive agreement to sell its global genomics business to Zoetis Inc. ("Zoetis"), the world’s leading animal health company, for $160 million, subject to customary closing adjustments. The planned divestiture, which had been previously announced, was part of the company’s portfolio review strategy to simplify the business and focus on core str
Turnover in East Texas politics may jeopardize regional sway at the Legislature
Some advocates for the region worry freshmen lawmakers will start deal-making at a deficit, while other voters see a chance for new blood.
For the first time, light mimics a Nobel Prize quantum effect
Scientists have pulled off a feat long considered out of reach: getting light to mimic the famous quantum Hall effect. In their experiment, photons drift sideways in perfectly defined, quantized steps—just like electrons do in powerful magnetic fields. Because these steps depend only on nature’s fundamental constants, they could become a new gold standard for ultra-precise measurements. The discovery also hints at tougher, more reliable quantum photonic technologies.
Xbox gets over 35 new games next week
A whopping 36 new games, including Marathon, Planet of Lana II, and Legacy of Kain: Defiance Remastered, launch for Xbox next week.
Birmingham residents urged to not let politics define it
The city has been compared to both a "cesspit" and a "powerhouse" during a heated council debate.
The Deeper Politics of the Washington Square Snowball Fight
There is definitely tension between Mayor Zohran Mamdani and his police department. Will it break out into the open?
Delray Beach sets new decibel limits for its entertainment district
Delray Beach is updating its noise ordinance to set defined decibel limits for businesses and vehicles, in areas along Atlantic Avenue.
Streaking Reed Sheppard leads Rockets into matchup with Heat
The Houston Rockets were on the verge of completing a stunning rally from a 19-point deficit against the Orlando Magic on Thursday but needed one final push to get over the hump.
1 Nutrient Is 'Out of Balance' In People With Anxiety. These Foods May Help
The brains of people with anxiety show an unusually large deficit in an “underconsumed and underappreciated” essential nutrient. Certain foods can deliver more of it.
Porsche responds after Resident Evil fans claim Leon will definitely destroy his Porsche in Resident Evil Requiem
Porsche’s Resident Evil Requiem collaboration has taken a turn, after fans reacted to the reveal trailer by joking that Leon S. Kennedy would destroy the Cayenne Turbo GT before the game even ends.
Did Germany's Merz pull off business balancing act in China?
Despite the cordial outcome of Chancellor Merz's business trip to Germany's largest trading partner and primary economic rival, a massive trade deficit and Chinese overcapacity remain key concerns.
iRacing Development Update: February 2026
Hello iRacers, The first few months of the year are an incredible time to be a motorsport fan. With real-world series deep into preseason testing or waving their first green flags, we get that first look at the new cars, technologies, and regulations that will define the season. As sim racers, we’re shaking off the … Read the Rest »
I Just Realized Why I Recognize 'Paradise' Star Sarah Shahi and I Can’t Believe I Almost Missed It
If you’ve been watching 'Paradise' and wondering why one cast member looks so familiar, you’re not alone. Here’s where you’ve definitely seen the actress before.