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Results for " rat " 42,808 found 🔀 AI-powered Shuffle

Vikings register highest blitz rate of Next Gen Stats era, at 85.2 percent
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Oct 25 • 10:34 PM EDT • Sports • sports.yahoo.com
A Healthy Balance Between Rigor and Mental Health

Many students of Irvington High School typically start their own nonprofits, strive to have 4.0 GPAs and more extracurriculars than can be counted on the fingers. This is typically seen as the “key” to accomplishing an acceptance to a prestigious university, creating a rigorous and competitive environment where students tend to prioritize academic excellence over...

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Oct 25 • 9:59 PM EDT • Health • ihsvoice.com
Illustration shows "Cyberattack" text and PHP code

The word "Cyberattack" and PHP code are displayed on a screen in this illustration taken on October 22, 2026.

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Oct 25 • 9:48 PM EDT • Business • lufkindailynews.com
DeForest Buckner is "frustrated" with the Colts
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Oct 25 • 9:31 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-70%)
Il Volo celebrates nearly 20 years of musical harmony

Longer than many marriages and most rock bands, the Italian singing trio Il Volo have been together for almost 20 years. They’ve gone from teenagers to 30-somethings while selling more

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Oct 25 • 9:00 PM EDT • Entertainment • floridaweekly.com
IN GOOD HEALTH: Preparing for respiratory illness season

By Leanna Coy, FNP-BC As temperatures begin to cool and the holiday season gets underway with Halloween this month, it’s time to prepare for fall and winter respiratory illnesses. As we…

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Oct 25 • 8:45 PM EDT • Health • tillamookcountypioneer.net
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Arizona business opens doors for employees with criminal records

An Arizona-based luxury door manufacturer is prioritizing hiring formerly incarcerated individuals to help them successfully re-enter society.

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Oct 25 • 8:41 PM EDT • Business • fox10phoenix.com
Politics Unplugged (Full Episode) Oct. 25, 2026

On this week's episode of Politics Unplugged, host Dennis Welch and a panel break down Arizona's election landscape one week out: pessimistic voter mood, suppressed independent turnout, lagging GOP enthusiasm, and Democrats gaining ground. They discuss Elon Musk's late spending in competitive House races and debate the impact of big money flooding the state. The show also covers a widely condemned Ohio attack ad by Vivek Ramaswamy that weaponizes a rival's childhood abuse—drawing praise from Trump and Vance but bipartisan outrage.

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Oct 25 • 8:31 PM EDT • Politics • azfamily.com
APTOPIX Brazil Election

Supporters of President Luiz Inacio Lula da Silva celebrate after he won the presidential runoff in Rio de Janeiro, Sunday, Oct. 25, 2026. (AP Photo/Lucas Landau)

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Oct 25 • 8:28 PM EDT • Business • telegraphherald.com
Four Positives From Frustrating Start To New Orleans Pelicans Season

These are some of the biggest positives to take away from the first few games of the New Orleans Pelicans' season.

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Oct 25 • 8:20 PM EDT • Sports • sports.yahoo.com
Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing

Peyton Manning is one of the greatest players, if not the greatest, to ever play for the Indianapolis Colts. The former quarterback is one of the most decorated players in American football history. He has won the Super Bowl two times, and is a five-time NFL Most Valuable Player. The Colts have not found the […] The post Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing appeared first on Gridiron Heroics.

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Oct 25 • 8:08 PM EDT • Sports • sports.yahoo.com
Claude AI accessed publicly available Georgia voter data, Anthropic confirms

Officials said the AI bot accessed publicly available voter data through the state's data hub but did not access voter files or Georgia's voter registration system.

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Oct 25 • 8:00 PM EDT • Business • foxbusiness.com
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Innovative food processing technique boosts Nebraska companies, educational outreach

Leadership and strategic visioning by Mary-Grace Danao, research associate professor in the Department of Food Science and Technology and the Department of Biological Systems Engineering, has helped position the University of Nebraska–Lincoln at the forefront of high pressure processing-focused food safety research in partnership with private industry.

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Oct 25 • 8:00 PM EDT • Science • news.unl.edu
Decarbonizing Manufacturing Supply Chains: C-Suite Guide

Decarbonizing manufacturing supply chains guide for executives. Strategic insights on reducing carbon emissions while driving business growth.

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Oct 25 • 8:00 PM EDT • Business • weforum.org
Johnson & Johnson Deepens Hong Kong Commitment with Strategic Partnership to Accelerate Healthcare Innovation

Johnson & Johnson Deepens Hong Kong Commitment with Strategic Partnership to Accelerate Healthcare Innovation

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Oct 25 • 8:00 PM EDT • Health • biopharmaapac.com
Phantom Blade Zero review: dark wuxia martial arts masters with an apprentice's execution

S-Game's Unreal Engine 5 'kungfupunk' debut can't help but get tangled in frustrating design choices.

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Oct 25 • 8:00 PM EDT • Technology • creativebloq.com
Immediate Takeaways from Packers Frustrating Week 7 Loss in Detroit

The Green Bay Packers stood no chance of overcoming missed field goals, a stagnant ground game, and inexplicable officiating blunders.

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Oct 25 • 7:47 PM EDT • Sports • sports.yahoo.com
Thousands protest in Prague against public media funding reforms

Demonstrators allege Prime Minister Andrej Babis and his coalition's proposed reforms pose a threat to press freedom.

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Oct 25 • 7:29 PM EDT • Politics • aljazeera.com
7 Cars And Trucks That Have Some Of The Worst MPG Ratings Ever

Seven fuel-hungry vehicles, including the Ram TRX, Ferrari Enzo, Bugatti Veyron and Lamborghini LM002, return as little as 5 mpg.

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Oct 25 • 7:25 PM EDT • Technology • jalopnik.com
Elon Musk’s Grok Imagine Releases First Odyssey Episode With Wonder Studios

8 sources compared: Other (4), Western Mainstream (3), Latin American (1). Elon Musk’s Grok Imagine released the first episode of its AI-generated series “The Odyssey,” posting a seven-minute vid...

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Oct 25 • 7:23 PM EDT • Entertainment • newscord.org
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9th Circuit panel questions basis for feds' request to block 20,000 California ballots

Two judges questioned the Justice Department's lawyer about how the Trump administration's position squared with the law.

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Oct 25 • 6:54 PM EDT • Politics • latimes.com
Kids celebrate with big Halloween fun at University Health's Fall Fest!

Hundreds of children who were born prematurely or with special needs reunited Thursday night for University Health’s annual Halloween Fall Fest, turning a night that was only open to families into a celebration of

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Oct 25 • 6:53 PM EDT • Health • news4sanantonio.com
Families celebrate Halloween with a side of science at Nature Museum

The Peggy Notebaert Nature Museum invited families to its annual BOO-seum Bash Sunday, with animal encounters, hands-on activities and plenty of Halloween fun.

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Oct 25 • 6:42 PM EDT • Science • wgntv.com
Families celebrate Halloween with a side of science at Nature Museum
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Oct 25 • 6:42 PM EDT • Science • yahoo.com
Judges skeptical of Trump administration effort for force California to set aside mail ballots

A three-judge US Circuit Court of Appeals panel expressed significant skepticism Sunday over the Justice Department’s desire to inject itself into California’s midterm vote-counting process by forcing election officials to set aside the votes of suspected noncitizens who have been issued mail ballots.

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Oct 25 • 6:38 PM EDT • Politics • cnn.com
Pirates Should Re-Sign This Upcoming Free Agent

Gregory Soto could still be a solid piece in the Pittsburgh Pirates bullpen in 2027.

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Oct 25 • 6:20 PM EDT • Sports • sports.yahoo.com
Democrat Coumba Kebe wants to keep the politics out of the treasurer’s office

Political newcomer Coumba Kebe is the Democratic nominee for Indiana state treasurer. Kebe wants to keep the politics out of the office and build back trust with people.

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Oct 25 • 6:03 PM EDT • Politics • purdueexponent.org
Trump escalates rhetoric against El-Sayed as he tries to undermine Democrat in Michigan Senate race

The Republican president has been attacking El-Sayed's faith throughout the campaign and claiming his past statements and background show a sympathy for extremists.

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Oct 25 • 5:50 PM EDT • Politics • pbs.org
Novant Health hosting Hilton Head hiring event Oct. 28

Novant Health will host a healthcare hiring event Oct. 28 on Hilton Head Island for nursing, laboratory, pharmacy and other positions.

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Oct 25 • 5:22 PM EDT • Health • wtoc.com
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Why Democrats see a path to victory in Mississippi midterm election
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Oct 25 • 4:30 PM EDT • Politics • cnn.com
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New Sistersville General Hospital marks milestone with final beam signing

Memorial Health System celebrated a milestone for the new Sistersville General Hospital with a final beam signing ahead of its 2027 opening, marking progress on expanded rural health care.

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Oct 25 • 4:17 PM EDT • Health • wtap.com
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Brad Pitt's Underrated Sci-Fi Astronaut Movie Deserved Better At The Box Office

You likely missed this critically acclaimed Brad Pitt sci-fi thriller when it was in theaters, but it's a film that warrants a watch.

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Oct 25 • 4:17 PM EDT • Entertainment • yahoo.com
Alaska Democratic Senate candidate Mary Peltola and her family suffer minor injuries in car crash

Peltola required medical attention after the accident, which happened when another vehicle crashed into the one transporting Peltola and her family, the campaign said.

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Oct 25 • 4:11 PM EDT • Politics • pbs.org
How Pratt Proved Brewers Right in the World Series

Shrugging off an early error, rookie Cooper Pratt delivered a clutch game-winning hit, vindicating the Milwaukee Brewers long-term investment.

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Oct 25 • 4:00 PM EDT • Sports • sports.yahoo.com
Primark's Business Doesn't Make Sense

In a world where fast fashion giants like Shein, Zara, and H&M drop thousands of new styles every day — and rake in billions through e-commerce — Primark is doing the unthinkable: thriving with zero online shopping. So what gives?*Want to Know the 5 Trends Changing Modern Retail? Find Out Here:* 🔗 https://clickhubspot.com/d13ac2In this video, we take you inside Primark’s weirdly brilliant business model — a model that’s stuck in the past on purpose. From warehouse optimization and floor-ready freight shipments to why the pandemic didn’t push them online, we unpack how this low-cost retail giant has managed to defy digital norms… and make it work.This isn’t just about one brand. It’s a story about modern retail expectations — and what it actually takes to meet (or reject) them.Subscribe to The Hustle:🔗 https://clickhubspot.com/vu3lGet the 5-minute newsletter keeping 2M+ innovators in the loop🔗 https://clickhubspot.com/3klnAbout HubSpot: HubSpot is a customer platform that provides education, software, and support to help businesses grow better. The platform includes marketing, sales, service, commerce, operations, and website management products that start free and scale to meet our customers’ needs at any stage of growth. Today, thousands of customers around the world use HubSpot’s powerful and easy-to-use tools and apps to attract, engage, and delight customers.#TheHustle #HubSpot

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Oct 25 • 3:31 PM EDT • Business • finance.yahoo.com
Mid-Hudson Valley business calendar for the week of Oct. 26, 2026

Mid-Hudson Valley business calendar

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Oct 25 • 3:20 PM EDT • Business • dailyfreeman.com
Why is the U.S. accusing Canada of election interference?

the U.S. Embassy accused Canadian officials of meeting with Democratic lawmakers, urging the use of retaliatory levies to hit Republican states, and running anti-tariff political advertising.

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Oct 25 • 3:13 PM EDT • Politics • inquirer.com
Kaine, Randall tour county's new Crisis Receiving and Stabilization Center

The Loudoun County Crisis Receiving and Stabilization Center's first day of operations on Oct. 22 included a tour by Sen. Tim Kaine, D-Va., and county Board of Supervisors Phyllis J.

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Oct 25 • 3:00 PM EDT • Health • loudountimes.com
Halloween evolved as a Frankenstein of cultural celebrations

The holiday has origins in Celtic, Roman and Catholic festivals and feasts, and mixed with other traditions as it spread.

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Oct 25 • 3:00 PM EDT • Entertainment • theshorthorn.com
Who's running to be Oklahoma's next Commissioner of Labor?

Republican Kevin West, Libertarian Mike Hall and Democrat Kevin Dawson will face off in November to be the next Commissioner of Labor.

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Oct 25 • 2:46 PM EDT • Politics • kgou.org
Alaska Democratic Senate candidate Mary Peltola and her family suffer minor injuries in car crash

Alaska’s Democratic Senate candidate Mary Peltola and her family suffered minor injuries Saturday in a car crash while driving to a campaign stop, her campaign said.

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Oct 25 • 2:30 PM EDT • Politics • news4jax.com
Opening Odds: Separating the real from the fake

Mizzou returns to action this week, and we’ll learn more if they’re real or fake.

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Oct 25 • 2:23 PM EDT • Sports • sports.yahoo.com
The Future of IBD Treatment: 4 Promising Therapies to Know About

New treatments are in development for inflammatory bowel diseases like Crohn’s disease and ulcerative colitis. Find out what experts say you should know.

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Oct 25 • 2:21 PM EDT • Health • health.yahoo.com
Nintendo reveals why you don't actually fight Bowser in Super Mario Bros. 1

Nintendo’s Shigeru Miyamoto has shared some insight into why players don’t actually fight Bowser in the original Super Mario Bros. Miyamoto was present at a press conference at the end of the week to celebrate him becoming the first developer to win Japan’s Order of Culture award. During the event, he was asked to share behind-the-scenes stories about the making...

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Oct 25 • 2:15 PM EDT • Technology • nintendoeverything.com
MAPPED: The states Trump and top Democrats are targeting before Election Day

With Election Day less than two weeks away, Trump rallied in Florida, Georgia and Michigan as both parties deploy top surrogates to battlegrounds.

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Oct 25 • 2:15 PM EDT • Politics • foxnews.com
Windows 11 is apparently so bad that XBOX would rather cancel hardware than be forced to use the OS

A reported clash between Microsoft's XBOX and Windows teams suggests Windows 11's desktop may no longer be the foundation for Project Helix.

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Oct 25 • 2:14 PM EDT • Technology • windowscentral.com
Scientists Develop a Clever New Way To Kill Cancer Cells From the Inside

Scientists have developed an experimental strategy that exploits a chemical byproduct of cancer cells to produce anticancer drugs directly inside them. Scientists in Japan have developed an experimental method that uses a chemical produced by cancer cells to manufacture anticancer drugs directly inside them. The approach relies on carbon monoxide, a toxic gas that certain

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Oct 25 • 1:45 PM EDT • Science • scitechdaily.com
Projections for Cleveland Guardians’ Arbitration Eligible Players

The Cleveland Guardians have several key players arbitration-eligible this offseason.

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Oct 25 • 1:30 PM EDT • Sports • sports.yahoo.com
Elon Musk’s Grok Releases First AI-Generated “Odyssey” Episode

Months after Elon Musk promised that Grok Imagine would make an entirely AI “Odyssey” film, the tech mogul has partially followed through.

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Oct 25 • 1:22 PM EDT • Technology • variety.com
‘You Can See Everything’ surges with $19.5M at box office; ‘Clayface’ takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.

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Oct 25 • 1:17 PM EDT • Entertainment • seattletimes.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KCBS All News 106.9FM and 740AM

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Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KNSS Radio

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Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.

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Oct 25 • 1:16 PM EDT • Entertainment • clickorlando.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KMBZ

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Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.

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Oct 25 • 1:16 PM EDT • Entertainment • news4jax.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s...

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Oct 25 • 1:16 PM EDT • Entertainment • stamfordadvocate.com
'You Can See Everything' Surges With $19.5M at Box Office; 'Clayface' Takes No. 1

NEW YORK (AP) — DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s Elizabeth Holmes documentary “You Can See Everything,” which pulled in $19.5 million in its ...

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Oct 25 • 1:16 PM EDT • Entertainment • usnews.com
Hunter's Moon 2026: All About October's Full Moon And What To Expect Tonight

The title "Hunter's Moon" dates back generations, originating in the Northern Hemisphere because it typically follows the harvest season.

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Oct 25 • 1:09 PM EDT • Science • ndtv.com
How Argentina’s Folk Sounds Are Shaping a Generation’s Politics and National Pride

Milo J, Cazzu, and more stars are embracing music and traditions of the Argentine countryside, staving off pop homogenization and sharing their history with the world

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Oct 25 • 1:09 PM EDT • Politics • yahoo.com
Business People: Evereve names industry vet Sarah Clary to advise on creative

RETAIL Evereve, an Edina-based women’s fashion retailer, announced it has named Sarah Clary as advisory chief creative officer. Clary previously has led creative direction campaigns and brand strategy for Hill House Home, Veronica…

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Oct 25 • 1:01 PM EDT • Business • twincities.com
Blanche says Trump isn’t trying to meddle with Alaska election results by suing over Senate race

WASHINGTON (AP) — Attorney General Todd Blanche on Sunday defended the Trump administration's lawsuit to block certification of Alaska's Senate results if Repub

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Oct 25 • 12:51 PM EDT • Politics • wtop.com
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race

Attorney General Todd Blanche is defending the Trump administration’s lawsuit to block certification of Alaska's Senate results if incumbent Republican Dan Sullivan loses the race.

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Oct 25 • 12:49 PM EDT • Politics • news4jax.com
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race

Attorney General Todd Blanche is defending the Trump administration’s lawsuit to block certification of Alaska's Senate results if incumbent Republican Dan Sullivan loses the race.

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Oct 25 • 12:49 PM EDT • Politics • ksat.com
Police: Lancaster County health care worker assaulted

Incident occurred at WellSpan Hospital in Ephrata Borough, according to police.

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Oct 25 • 12:42 PM EDT • Health • wgal.com
Epic CEO Tim Sweeney lambasts “abhorrent” Steam AI Disclosure Policy claiming labels double as “political statement”

Epic Games CEO Tim Sweeney called Steam’s AI disclosure policy abhorrent, arguing that it exposes developers to backlash from anti-AI detractors. Valve has implemented and updated the policy since 2024, which states that AI-generated content, including artwork, text, music, and assets, excluding assistant tools, requires formal disclosure.

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Oct 25 • 12:31 PM EDT • Technology • notebookcheck.net
Health care shakes up the Iowa election

If Democrats flip Congress, health care could find its way to the top of their 2027 agenda.

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Oct 25 • 12:26 PM EDT • Health • politico.com
One Of Steven Spielberg's Biggest Box Office Flops Is An Underrated Disney Movie

Steven Spielberg is one of the most prolific directors to still be working, and he's known for absolutely stunning films, but not every movie can be a hit.

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Oct 25 • 12:17 PM EDT • Entertainment • yahoo.com
Kings' Veterans Praise Rookie Acuff After 33-Point Showing

The Sacramento Kings are yet to get a win, but Darius Acuff Jr. looks like the high-octane guard that the franchise so desperately needs. Coming off a 33-point outburst, how will Acuff play against the Memphis Grizzlies?

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Oct 25 • 12:13 PM EDT • Sports • sports.yahoo.com
Memorial Health celebrates staff with trunk-or-treat

Memorial Health went all out for its annual trunk-or-treat event, celebrating team members and their families.

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Oct 25 • 12:13 PM EDT • Health • kswo.com
😐 Neutral (9%)
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100%
Bloomington business continues to blossom

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Oct 25 • 12:11 PM EDT • Business • insideindianabusiness.com
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3 comments | Progressive Democrats are closely watching four Senate...

Progressive Democrats are closely watching four Senate races in the upcoming midterm elections. Our politics reporter Kellen Browning explains why.

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Oct 25 • 12:07 PM EDT • Politics • facebook.com
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Apollo: AI has delivered 'zero financial payoff' to corporate America

Only tech companies are seeing growth from the AI boom, Apollo Global Management said.

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Oct 25 • 12:02 PM EDT • Business • businessinsider.com
In West Maui, Democrat-turned-Republican defends House seat against Lahaina Strong organizer, local business advocate

Incumbent Rep. Elle Cochran, Green Party candidate Pā’ele Kiakona and Democratic nominee Sne Patel are battling to represent West Maui at a pivotal time in the fire recovery.

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Oct 25 • 12:01 PM EDT • Business • mauinow.com
Is having urine the color of Mountain Dew normal?

A Trump administration doctor says neon yellow urine is normal because of diets consisting entirely of meat and fermented foods. Here’s what experts say

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Oct 25 • 12:00 PM EDT • Health • health.yahoo.com
😐 Neutral (12%)
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57%
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In Texas Senate Race, Talarico Leans Into Growing Rivalry With Elon Musk

On the trail, James Talarico, the Democratic Senate nominee, has increasingly gone after Mr. Musk, a critic of his who has given big to a group aligned with the Republican candidate, Ken Paxton.

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Oct 25 • 11:53 AM EDT • Politics • nytimes.com
Scientists Discover a Plant Compound That Could Help Stop Rheumatoid Arthritis Inflammation

Scientists have identified a plant compound that reduced joint swelling and inflammation in rats with experimental arthritis. The discovery offers a potential new direction for rheumatoid arthritis tr...

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Oct 25 • 11:49 AM EDT • Science • yahoo.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
South Texas Health System (@stxhealthsystem)

1 likes, 1 comments - stxhealthsystem on October 25, 2026: "Exceptional Care Starts With You: Nurses play a vital role in every patient journey, providing the compassionate, skilled care that helps make South Texas Health System’s 12 facilities a trusted healthcare resource for communities across the Rio Grande Valley. If you're passionate about making a difference and delivering exceptional patient care, now is your opportunity to join the largest integrated healthcare network in the region. STHS is seeking dedicated and compassionate registered nurses to join its team at four acute care hospitals, a behavioral health hospital and seven freestanding emergency departments. Become part of a team committed to clinical excellence, collaboration and compassionate care. To view current openings and apply, visit the STHS careers page at the link in our bio.".

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Oct 25 • 11:18 AM EDT • Health • instagram.com
California election officials frustrated, rattled by DOJ demand to sequester 'noncitizen' ballots

The administration has insisted that immigrants voting is a major problem nationwide, when in fact it is quite rare, as even its own investigations have shown.

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Oct 25 • 11:17 AM EDT • Politics • pbs.org
Syria’s Democratic Transition: Building Institutions Alongside Political Competition

Syria’s post-Assad transition has revived debate over when to legalize political parties. Parties are essential to political competition,

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Oct 25 • 11:16 AM EDT • Politics • fairobserver.com
Mystery Ohio news site boosting Ramaswamy's Amy Acton ad tied to California GOP non-profit

As Ohio Republican gubernatorial candidate Vivek Ramaswamy came under fire for releasing an attack ad featuring his Democratic competitor Amy Acton's estranged mother, a mysterious news site was runni...

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Oct 25 • 11:08 AM EDT • Politics • yahoo.com
Stateliner Pride on Display: Phillipsburg Band and Alumni Unite at Halftime

Phillipsburg’s Stateliner band and alumni joined for a halftime performance celebrating school tradition, pride and community at Friday’s football game.

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Oct 25 • 11:00 AM EDT • Entertainment • tapinto.net
Rep. Haley Stevens sidesteps whether she still supports El-Sayed, criticizes outreach to Black voters
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Oct 25 • 10:59 AM EDT • Politics • cnn.com
AI-generated video heats up suburban Texas political clash

Fort Bend County has seen plenty of controversy at its highest levels.

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Oct 25 • 10:57 AM EDT • Politics • chron.com
Micron Just Revealed a New Business Strategy. That Change Makes It a Screaming Buy.

Micron is changing more toward contracts, rather than letting the open market dictate pricing.

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Oct 25 • 10:51 AM EDT • Business • finance.yahoo.com
‘What’s the crime?’: Bash presses Blanche over Alaska election lawsuit
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Oct 25 • 10:45 AM EDT • Politics • cnn.com
GeForce Unlocked: Modders Boost RTX 20, RTX 30, and RTX 40 Compute Performance by Up to 2x

NVIDIA's GeForce RTX 30-series and RTX 40-series graphics cards are based on the same dies as their professional-grade GPUs. This means the compute potential of consumer-oriented RTX GPUs is restricted by NVIDIA's firmware stack, but modders have managed to unlock the instruction issuing rate...

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Oct 25 • 10:43 AM EDT • Technology • techpowerup.com
Obama, in Midwest, assails 'cruelty' and indecency from Trump and his allies in the midterm campaign

Obama remains the Democratic Party’s best motivator nearly a decade after leaving the White House. And he's taking his star power on the road in the final days of the midterm elections, which will help determine the balance of power in American politics on Nov. 3.

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Oct 25 • 10:35 AM EDT • Politics • pbs.org
NC business co-owner kills man ‘acting irrationally’ outside Zumba class, police say

A man “acting irrationally” toward patrons of a Zumba fitness class was fatally shot when he turned his attention to an armed business co-owner at the scene, according to investigators in western North Carolina. The confrontation occ…

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Oct 25 • 10:20 AM EDT • Business • pilotonline.com
Instacart Stock What Health Benefits Deal And $5 Million Settlement Mean

Instacart parent Maplebear has agreed to a US$5,000,000 settlement with U.S. authorities over past PERM hiring practices and has been selected by True Rx Health Strategists to power an employer funded healthy food benefit through Instacart Health Fresh Funds starting in 2027. The True Rx program positions Instacart within pharmacy benefit design and ties employer spend directly to clinically supervised food choices. The settlement adds compliance obligations, policy changes and monitoring...

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Oct 25 • 10:08 AM EDT • Health • finance.yahoo.com
Inside California Politics: State Senate candidate John Erickson

(Inside California Politics) — California’s top-two primary system often leads to same-party general election races, often between two Democrats, and this year is no exception. Two weeks ago on Inside...

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Oct 25 • 10:00 AM EDT • Politics • yahoo.com
Culture House Wants to Turn Creator Connections Into Lasting Businesses

Culture House connects creators directly with investors and operators, helping turn cultural influence into sustainable businesses.

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Oct 25 • 10:00 AM EDT • Business • inc.com
Investment driving growth at NWS Crane

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Oct 25 • 9:53 AM EDT • Business • insideindianabusiness.com
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Jeffries: Democrats ‘on the verge of taking back control’ of the House
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Oct 25 • 9:48 AM EDT • Politics • cnn.com
Clemson HC Dabo Swinney Waving White Flag on Season

Following a humbling loss to Virginia Tech, Dabo Swinney is recalibrating expectations as the Tigers abandon playoff dreams and fight to salvage a disappointing, sub-par season.

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Oct 25 • 9:36 AM EDT • Sports • sports.yahoo.com
Physician Mental Health and Health System Privacy: Why Doctors Avoid Their Own EHR

In most organizations the default access model was built for patient care, not for protecting colleagues. A nurse on another unit, a resident who rotated with them, a department administrator: any of them may technically be able to open the record, even when policy says they should not.

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Oct 25 • 9:21 AM EDT • Health • medcitynews.com
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Business co-owner kills man ‘acting irrationally’ outside Zumba class, NC police say

The business co-owner was carrying a firearm, Spindale police say.

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Oct 25 • 9:12 AM EDT • Business • charlotteobserver.com
One Underrated Timberwolves Wing Gets High Praise From Chris Finch

Terrence Shannon Jr. is shaping up to be one of the Timberwolves' sneakiest threats.

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Oct 25 • 9:00 AM EDT • Sports • sports.yahoo.com
‘Dream big’: The Seattle-area kids and teens launching businesses

Some among the Seattle area's Generation Z and Alpha age groups are diving headfirst into entrepreneurship.

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Oct 25 • 9:00 AM EDT • Business • seattletimes.com
Trump campaigns in Michigan one day after Obama rallied against him

President Donald Trump will campaign for nominee Mike Rogers in Michigan, a day after former President Barack Obama criticized his administration in the state. Follow for live updates.

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Oct 25 • 8:30 AM EDT • Politics • cnn.com