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Oregon Already Getting Disrespected by ESPN After Week 1 Win
Oregon had a very strange opening game on Saturday against Boise State. I think some are forgetting that Boise State is one of the better teams in the country, and while Oregon could have and should have played better, there's a very good scenario in which Boise State is a playoff team. We have to remember that at the end of the day, especially with Oregon still winning this game, the defense stepped up when needed.
Viewpoint: Unlocking Europe’s wildfire data
Europe is already investing in the science, technology and infrastructure needed to understand, prevent and fight wildfires. Copernicus provides satellite-based Earth observation and environmental information, while the European Forest Fire Information System provides information on fire danger and forest fires across Europe. Weather and climate systems add forecasts of heat, drought, wind and humidity; historical fire databases show where fires have occurred; and researchers generate increasingly detailed knowledge about fuels, fire behaviour, forecasting, modelling and risk management. Meanwhile, new European research projects are adding digital twins and other tools to this growing ecosystem.However, these data do not necessarily sit together, nor are they necessarily described, structured or governed in ways that allow them to be used together. Much of the information is public, but some is commercially held. Some is sensitive. Some is subject to legal, security or operational restrictions. Even when data can be legally accessed, different systems may use different formats, terminology and rules.Europe therefore faces an unusual paradox: we have vast amounts of relevant information to respond to the wildfire challenge, but not the means to bring it together. For example, a wildfire researcher or emergency service might need to ask whether a particular combination of vegetation, drought, wind and topography has historically been associated with rapid fire spread. The relevant information may exist in several institutions, using different systems and subject to different conditions of access.The challenge is to conduct an authorised analysis that interacts with these sources, combines the results and respects the rules imposed by each data custodian.An important part of the answer can be found in the Fair principles, the idea that data should be findable, accessible, interoperable and reusable. Developed more than a decade ago, these principles have become a central reference point for modern data stewardship, making it easier for people and machines to find data, understand what it means and determine whether it can be reused.Readability by machines is essential, since AI systems will be key to meeting the data challenge. Bring analysis to the dataThe proposition is not to give an AI system unrestricted access to sensitive databases. Quite the opposite. The goal is to make it possible for approved algorithms to go to the data, rather than requiring sensitive data or large datasets to be copied to wherever the analysis happens.Imagine an analysis asking a series of questions of different data stations. At one station it might examine weather and climate data; at another, historical fire records; at another, experimental measurements of fire behaviour. The algorithm does not need to download everything. It can operate within the environment permitted by each data custodian and return only the results that the rules allow to leave.This is sometimes described as data visiting, and related approaches already exist in areas such as federated analysis and federated learning.Sensitive data should therefore not be treated as a free-for-all for machines. This requires appropriate governance at multiple levels. Access needs to be authenticated and authorised. The purpose of an analysis should be defined. The code or model being run should be controlled. Data custodians should be able to specify what can be queried and what results can leave their environment. Activities should be auditable and human oversight should remain where the consequences require it.In other words, the objective is not to trust AI with the data. It is to design systems in which AI never has more access than it needs.As open as possible, as closed as necessaryFair data should also not be confused with open data. Some wildfire data should be openly available. Other information may legitimately need to remain restricted because it concerns critical infrastructure, security, commercial interests, privacy or operational capabilities. The principle should be: as open as possible, as closed as necessary.The important point is that restricted data should not automatically become unusable data. If machines can discover what information exists, understand its meaning, establish where it came from and determine the conditions under which it can be used, authorised analyses can potentially be carried out without the underlying data ever leaving the environment in which it is protected.Restricted data can still be Fair and machine-actionable.This is also an important question of data sovereignty. European institutions should not have to surrender control of their data to a handful of technology platforms in order to benefit from AI. Nor does Europe need to start again by building one giant repository for every piece of wildfire information. The better approach is to connect what already exists.This is the principle behind emerging approaches such as Tryangle, developed through the Leiden Initiative for Fair and Equitable Science. Rather than creating another centralised data warehouse, the approach seeks to provide an interoperable layer through which approved algorithms can visit distributed data sources while respecting the rules of their custodians.In this way, a data station can remain where it is. Its custodians can retain control. Existing databases and applications do not have to be abandoned. What changes is their ability to communicate with other systems through common, machine-readable descriptions, access rules and interoperability mechanisms.But approaches like this need data that meets the Fair principles. Only then can an interoperable ecosystem safely begin to turn fragmented information into collective intelligence.Data infrastructure is wildfire infrastructureThe implications of this approach are entirely practical. Firefighters could gain better intelligence about local and evolving risks. Land managers could test prevention strategies using more comprehensive information about fuels, weather and past fires. Researchers could compare evidence across ecosystems without repeatedly moving huge datasets between institutions. Smaller regions and resource-constrained teams could access analytical capabilities without having to build large data infrastructures themselves.Europe is already investing heavily in satellites, databases, research programmes, forecasting systems and scientific expertise. The question is whether we will connect those investments well enough to turn them into actionable intelligence.That requires policymakers and funders to treat data infrastructure as seriously as physical infrastructure. Data generated or supported through European public funding should be Fair, verifiable and machine actionable by design, wherever legally and ethically possible.Related articlesData Corner: Europe’s burning need for wildfire mitigation researchClimate monitoring must remain a global enterprise, experts sayIn practice, that means funding not only the production of data, but also the infrastructure that makes data usable across systems: metadata, provenance, interoperability, access mechanisms and governance. Where data must remain restricted, we should ensure that it can still be securely discovered, verified and used for authorised analysis.Initiatives such as the European Open Science Cloud offer an existing framework through which these principles can be put into practice. What is needed now is to accelerate implementation and make them a standard part of how Europe funds and builds research and innovation systems.We do not need another generation of disconnected databases. The data is already there. The opportunity is to make it work together, securely, responsibly and quickly enough to help prevent the next fire, rather than simply document the last one.Jean-Claude Burgelman is professor emeritus at the Free University of Brussels (VUB) and editor-in-chief at Frontiers Policy Lab. For more than 20 years he held leading roles in research and innovation policy at the European Commission.
Tigers’ series win offers some encouraging glimpses of 2027
It’s too little, too late for the playoff chase in 2026, but the Detroit Tigers showed this week they’re still capable of playing clean baseball.
New wave of healthcare fraud enforcement
In past years, federal and state authorities typically initiated healthcare fraud investigations based on whistleblower complaints and audits. While that still occurs, the model is changing. Federal enforcement agencies are increasingly using sophisticated data analytics, artificial intelligence, and coordinated investigative efforts to identify potential fraud. The Department of Justice (DOJ),…
Madison council rejects Willy Street business relief proposal
The proposal was tied to businesses still dealing with the aftermath of the Ruiz shooting.
How 9/11 changed NYC Council Speaker Julie Menin's life and set her on a path to politics
Henry Winkler details rift with Tom Hanks over “Turner & Hooch” firing: ‘I am still working on my perspective’
“I guess at that time, being insecure, I talked too much,” the “Happy Days” star reflected.
Billy Joel addresses his health, tells fans not to worry: 'I'm still here'
Billy Joel shared an update about his health more than a year after being diagnosed with normal pressure hydrocephalus.
Luminis Health cyberattack delays cancer treatment and test results
The health system said it is still trying to determine which systems and how many patients are affected across its entire organization.
Newcastle still open to Hall sale
Lewis Hall could still leave Newcastle despite new contract, Yasin Ayari close to committing to Brighton but Kaoru Mitoma set for exit, and Chelsea to go back for Manu Kone in midfielder search.
Voters could move Congress to revisit H.R. 1 healthcare overhaul, Kaine and McClellan say
It would still be a long shot, he and U.S. Rep. Jennifer McClellan, D-Richmond, noted. But since H.R. 1 passed, every member of Congress has spent time in their districts hearing from their constituents, as voters name healthcare a chief concern.
Dodgers Still Weigh Two Very Different Paths for Sasaki’s Return
As a nagging right middle finger blister heals, the Los Angeles Dodgers must decide if Roki Sasaki serves the postseason run best as a high-intensity reliever or a stabilized rotation anchor.
Hollywood’s ‘new business model’ comes into view as Gen Z shows a moviegoing taste that combines ‘fast food and fine dining’
Theaters sold nearly 249 million fewer tickets than in 2019 but still set a $4.7 billion summer record. It’s not 2019 anymore.
Apple Reveals iPhone 18 Pro and iPhone 18 Pro Max Battery Capacities
Apple has confirmed the battery capacities for the iPhone 18 Pro and iPhone 18 Pro Max models that the company announced earlier today. Apple is required to publish energy labels on its iPhone product pages in the EU, and they reveal the official mAh battery capacities for the devices. Here are the battery capacities for the iPhone 18 Pro and iPhone 18 Pro Max models that still have a SIM card tray, according to Apple: iPhone 18 Pro: 4,056 mAh (+1.7% vs.
Read the Apple document explaining how new listening features still protect your privacy
Will you be using Audio Intelligence?
Longtime film academy chief executive Bruce Davis dies at 83
LOS ANGELES — Bruce Davis spent more than two decades as the motion picture academy's chief executive. Even when he retired in 2011, it was not because he didn't still
Saints’ Rookie Named ‘Future Hit’ Ahead of Week 1
The New Orleans Saints still have some questions to be answered at the wide receiver position.If Bryce Lance reaches his potential quickly, though, that could solve a lot of potential issues.And there appear to be at least some people around the league who are big believers in Lance.The Saints took Lance in the fourth round […] The post Saints’ Rookie Named ‘Future Hit’ Ahead of Week 1 appeared first on HEAVY.
NMSU FIRE Venture Fellow completes summer internship with El Paso health innovation startup
Grace Valentine Olagunju, a New Mexico State University graduate student and member of the 2026 Fourth Industrial Revolution Economy Venture Fellows cohort, has completed a summer internship with...
Pixel 11 Pro vs. iPhone 18 Pro: Which to Buy?
Apple shared its new hardware line-up for the end of 2026 today, revealing the iPhone 18 Pro, iPhone 18 Pro Max, iPhone Duo, new Apple Watch models, and some new AirPods. For those who missed the event and don’t want to re-watch, yet still want to see how the new iPhone 18 Pro compares to...
How to Watch Seahawks Games Without Cable in 2026
The defending champion Seattle Seahawks will be must-watch TV in 2026. Fortunately, even if you don’t have cable, you can still easily watch them.Your options will vary depending on what exactly you’re looking for, and whether games are in or out of your market, but no matter your situation or location, we have the full […] The post How to Watch Seahawks Games Without Cable in 2026 appeared first on HEAVY.
Shooting to the top with a new form factor? - Samsung Galaxy Z Fold8 review
Samsung Galaxy Z Fold8 review: How does Samsung’s new foldable smartphone perform in everyday life? We evaluate the display, performance, camera, battery, and usability, and reveal exactly who the Fold8 is for—as well as where this foldable flagship still has work to do.
Netflix orders new series based on Larry McMurtry’s ‘Lonesome Dove’
The book originally published in 1985.
The foldable iPhone Duo is Apple's boldest smartphone experiment yet
Apple has stuck to the long, rectangular iPhone shape since 2007. The new iPhone Duo foldable shows Apple is still willing to experiment.
Scientists Discover the Earliest Evidence of Drug Use in Really Old Teeth
A hunter-gatherer who lived in Indonesia as early as 25,000 years ago may have regularly sucked on betel nuts to release their psychoactive properties.
Skip iPhone Duo and Slap $300 Off Galaxy Z Fold 8
It might be iPhone Duo day, but Samsung still has two excellent new foldables it doesn’t want you to forget about. Both the Galaxy Z Fold 8 Ultra and Galaxy Z Fold 8 are discounted heavily with no trade-in required. Instead of being an iPhone Duo beta tester, you can go with the best foldables...
Gov. Andy Beshear says arrest of former Gov. Matt Bevin shows 'the rule of law still applies'
Americans prefer getting bitten by a mosquito or stubbing their toe than today’s politics
Respondents still prefer today’s politics over billionaires, telemarketers, health insurance companies, artificial intelligence, Elon Musk and root canals.
New CNN poll in Maine shows a razor-thin contest between Sen. Susan Collins and Troy Jackson
Detroit's Dylan Larkin 'wants to be' in Minnesota, insider says
With the season less than a month away, Dylan Larkin may still be focused on his exit from Detroit, with Minnesota as his preferred landing spot.
An onslaught of midterm polling is coming. Here’s how to sort through it
If read carefully, high-quality polls can still tell you a lot about how this year’s midterms are shaping up – and keeping a few simple questions in mind can help you sort through the overwhelming and sometimes overblown deluge of data.
N.C. population growth slowing but political impact still significant
While North Carolina’s population rose by 180,000 residents from 2023 to 2024, its growth rate diminished to 146,000 residents between 2024 and 2025.
How Social Media and AI Chatbots Are Reshaping Youth Mental Health, and What Congress Can Do About It
It’s hard to move legislation in Washington, DC right now. Congress seems deadlocked on even commonsense ideas. But there is one spot where we still see consistent bipartisan collaboration: youth mental health. That’s because the youth mental health challenge is vast. Nearly half of teenagers and two-thirds of young adults regularly experience mental health distress, yet only a small … Continued
Bruce Willis’ wife says he’s still ‘very present’ in health update amid dementia battle: ‘Learned to adapt’ (exclusive)
EW has an exclusive look inside Emma Heming Willis’ life with Willis, who still has “beautiful moments of joy and connection” amid “terrible” diagnosis.
Bruce Willis still ‘very present’ amid ‘terrible’ dementia diagnosis (exclusive)
Bruce Willis’ wife, Emma Heming Willis, has given a health update on the actor and how his family ‘learned to adapt’ amid his ‘terrible’ dementia diagnosis: ‘He’s very present.’
Lava-Covered Planets Are Defying a Key Rule of Planetary Science
Researchers developed a model showing how lava-covered planets close to their stars can hold onto their atmospheres, which could help guide the search for life beyond our solar system. Some planets orbit so close to their stars that intense radiation should strip away their atmospheres. Yet several of these scorching, lava-covered worlds still retain thick
Hoping customers would return after Operation Metro Surge, immigrant businesses are still waiting
These anecdotal reports match preliminary data from government and other researchers.
Can the Orioles help these players reach their maximum potential?
Baltimore’s roster has been filled with disappointments this season, but a group of young players still possess significant potential.
NFIB reports slight dip in small business optimism
Owners cite weaker sales, inflation and supply chain strains, while many still struggle to find qualified workers.
Scientists Who Study Sleep and Narcolepsy Win Prestigious Lasker Award
The two researchers have won a prestigious Lasker Award. Their findings laid the groundwork for a new drug that addresses the sleep disorder’s root cause.
Mental health survey finds Yampa Valley residents struggle with loneliness, substance use disorders
The Steamboat Springs City Council heard a sobering assessment of behavioral health in the Yampa Valley on Tuesday: Despite strong awareness of local resources and a reputation for community support, many residents still face loneliness,...
America Is In Pain. Flagler Health Is Transforming Clinics On The Front Lines
Hinge Health put MSK care on the digital-health map. Flagler's $50M Series B reflects a different bet: use AI to transform the specialty clinics where care still happens
Eberl reveals Bayern explored move for Barcola before Liverpool switch
Bayern Munich were linked with a move for Bradley Barcola in the past, when he was still playing for Paris Saint-Germain, but ultimately chose not to pursue their interest.In an interview with Sport B...
Jaguars CB Montaric Brown Predicted to Regress this Season
After a breakout campaign in 2025, one analyst is still not convinced that Montaric Brown is an above-average starting cornerback for Jacksonville.
Samsung 'advice' to Apple suggests it fears the build quality of the iPhone Duo
Samsung says it welcomes Apple’s entry into the foldable smartphone market, although the company appears to feel threatened by the...
FDNY unions to address 9/11 health concerns after NYC releases new air quality documents
14 of Science’s Biggest Mysteries We’re Still Trying to Figure Out
There’s a lot we know today that humanity didn’t know hundreds of years ago, and there will likely be a lot people will learn in the coming years that we can’t possibly know right now. Among these que...
Top Three Commanders to Target in Fantasy Football This Season
The Commanders have plenty of questions heading into Week 1, but there’s still fantasy value to be found in Washington. From Jayden Daniels to Terry McLaurin and Stefon Diggs, these three players could make a major impact for fantasy managers in 2026.
Why does early treatment matter for psychotic episodes?
Early treatment for psychosis can improve recovery and challenge the idea that mental illness means a lifetime of suffering.
Europeans struggle to imagine 'credible' future, study finds
New research identifies an 'imagination gap' as where political choices can still matter
Europeans struggle to imagine 'credible' future, finds study
New research identifies an 'imagination gap' as where political choices can still matter
Sphere Entertainment (SPHR) Expands 4D Wizard Of Oz As Valuation Hinges On Growth Story
New 4D effects spotlight Sphere Entertainment’s product ambitions Sphere Entertainment (SPHR) just rolled out an expanded 4D package for The Wizard of Oz at Sphere, adding animatronic Winged Monkeys, themed scents, Glinda Glitter, pyrotechnic fireworks, and scented apples from September 25, 2026. For investors watching Sphere Entertainment, the latest 4D upgrade lands after a choppy few months, with the share price down about 11% over 30 days but still showing strong momentum through a 51%...
Angel Reese Is Getting Way Too Good to Ignore
At some point, we have to stop calling Angel Reese a “future star.” She is already a star. Reese has taken her game to another level with the Atlanta Dream, averaging 16.1 points, 12.4 rebounds, 2.8 assists and 1.8 steals per game this season. And somehow, she still feels like one of the most underrated…
Lindsay Clancy and postpartum psychosis
The trial around Lindsay Clancy may be over for now, but it still leaves us with questions. On today’s episode, we talk to psychiatrists and patients to answer them: What is postpartum psychosis, exactly? Why don’t we know more about it? And what can you do if you are worried about a postpartum loved one?Interested in more stories on mental health? Email us your question at shortwave@npr.org.Support public media with NPR+ and enjoy perks for over 25 podcasts like this one. This show’s perks include sponsor-free listening. Learn more at plus.npr.org.
USI drops their second straight match at home
EVANSVILLE, Ind. (WEHT) — The University of Southern Indiana men’s soccer is still looking for their first win under new head coach Mads Kaiser after falling 2-1 to Bellarmine. The loss was their second straight at home after falling to IU Indy last week. The Knights got on the board first in the first half with […]
Royals postpone the inevitable, but the inevitable still came
The bullpen did bullpen things
Dan Lanning's Ducks still not ready for college football's primetime
Oregon struggled to find consistency against Boise State to open the season.
Pittsburgh Pirates Slim Playoff Hopes No Longer in Their Hands
The Pittsburgh Pirates' playoff hopes are technically still alive, but they'll need a lot of outside help to make it to the postseason.
Packers’ 3 biggest concerns entering 2026 season
The offensive line is chief among the potential issues for the Packers as they enter 2026, with the health status of Zach Bako-Bewele still uncertain.
New York braces for impact of retaliatory tariffs
As the issue becomes a flashpoint in the November midterm elections on one hand, the real day-to-day economic impact is playing out on the other.
Pirates Trying to Find This Balance With Konnor Griffin
The Pittsburgh Pirates need Konnor Griffin in the lineup, while also being mindful that he's still coming back from injury.
Ubisoft joins Xbox's disc-to-digital program, with more publishers to follow
Some outlets were highlighting Ubisoft's lack of involvement in Xbox's disc-to-digital program. Perhaps we should remind ourselves that it's still in Alpha testing.
Recent 49ers moves hint towards George Kittle return
The possibility of George Kittle playing in the San Francisco 49ers' Week 1 game against the Los Angeles Rams is still up in the air. But based on recent moves, the stars are aligning towards a potential return.
The 98 Biggest TV Show Flops, Bombs and Misses in the First Half of 2026
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) In July, I updated my look at how the “streaming bubble” popped since 2023, showing the decline in streaming TV shows over time. But after compiling and analyzing and writing about over one hundred TV show flops in the first half of 2026—I counted 99 “nominees” and there are even more honorable mentions—I couldn’t have told you that the number of shows is going down. When it comes to scripted, English-language TV shows, it feels like we have as many bombs as ever. I don’t keep a specific count, but some streamers probably had as many flops as they’ve ever had.1 That’s right, it’s time for part two of my analysis of the biggest flops, bombs and misses on streaming in the first half of 2026. Two weeks ago, I took a look at films. Today, TV shows. If you want to read the full methodology for how I assemble this list, you can find it at the bottom of this article. In short, this list is… ...scripted and unscripted TV shows,...from the nine major streamers,...in the US (using US-only ratings),...excluding true crime, kids and foreign-language shows,...that got no/poor ratings,...from Jan-2026 to the end of June-2026. Reminder: this article does not represent my personal opinion—many of these shows are great!—but I follow the data, and a miss is a miss and a bomb is a bomb. Also, price matters. If a TV show costs north of $100 million, it needs to get lots and lots of streaming viewership to justify that budget. As with past editions, I ordered this list by streamer, going from best (fewest flops) to worst (the most misses)—taking the size of the flops into consideration—and like the last edition, three or four streamers vied to take the win/loss of having the most flops. (But the actual winner is no surprise.) I try to avoid tooting my own horn too much, but seriously, in just under 5,000 words (including the methodology section) I provide a mostly comprehensive overview of the eight major streamers (Netflix, Disney+, Prime Video, Hulu, HBO Max, Peacock, Paramount+, and Apple TV) for the first half of the year, mentioning most of their hits and all their misses. It summarizes the entire first half of 2026! If you want to support this work, please subscribe. Subscribe Tubi Big Mood Boarders The Freak Brothers Twenty Twenty Six Honorable Mentions: Busted on Bodycam, Deestroying the Pitch, Destination World Cup 2026 I don’t think that Tubi spends all that much making or (mostly) licensing these original TV shows—Big Mood, Boarders and Twenty Twenty Six all come from the UK—but they’re not free and they didn’t chart anywhere. Winner: The Freak Brothers Have you even heard of this show? It’s an animated comedy...that’s on its third season! And Pete Davidson, Woody Harrelson, John Goodman and Tiffany Haddish all provide voice talent for it. Yes, animated shows don’t cost as much as live action shows, but cheap isn’t free! So a show with this level of talent needs to perform better. Disney+ Daredevil: Born Again Star Wars: Maul – Shadow Lord Honorable Mentions: Behind the Attraction, Donna Hay Coastal Celebrations, We Call It Imagineering Disney+ doesn’t make all that many original shows anymore. They had two flops, and one was animated. Their one not-a-miss show, Wonder Man, got just good enough viewership to not be considered a “miss”...but it’s since been cancelled. At this point, Disney has pivoted entirely away from making big budget TV shows for Disney+ to making...almost nothing for Disney+? Sure, Disney’s spending circa 2019-2022 was unsustainable, but now they’re pivoting too far in the other direction. At some point, Disney needs to stop shifting strategies so wildly. Really, Disney should have made fewer shows for Disney+ at launch and the shows they did make at that time needed to be made at more reasonable budgets. And they should adopt that strategy now. Winner: Daredevil: Born Again Daredevil, the Marvel Comics character, is on my personal Mount Rushmore of favorite superheroes, so it pains me to give him the win/loss today, but this show deserves it. I’ll repeat my hot take from last spring: “Based on his popularity, Daredevil should be in movies, and probably ones that cost a lot less than the MCU’s usual price tag. Disney/Bob Iger/Ike Perlmutter (who, based on reporting, made the decision) made a huge mistake selling TV shows to Netflix in the 2010s, thus limiting this character to the small screen. Daredevil could have anchored Marvel’s post-Infinity War plans, and if he did, the MCU would probably be in a better place than it is now.” HBO Max We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… What four streamers had the most misses... HBO’s strong start to 2026… The caveat to Peacock’s turnaround this year... Paramount+’s key man problem… What country isn’t delivering hits for Netflix or Hulu... The cavalcade of stars on a streamer where no one is watching their shows... Across nearly 5,000 words of analysis… And a lot more... ...please subscribe! We can only keep doing this great work with your support. If you’d like to read more about why you should subscribe, please read this article about the Streaming Ratings Report, why it matters, why you need it, and why we cover streaming ratings best.
STEAM Minute | The science behind developing and restoring film
While digital photography is the most common way to take pictures now, many people still use film photography for its unique look and nostalgic feel.
Severe Warning Issued Over Technique Putting Patrick Mahomes at Risk
The Kansas City Chiefs fans are still not completely certain whether Patrick Mahomes will be starting in the season’s opening Week 1 game. The team suffered heavily last season when the quarterback suffered an ACL injury that has kept him out for a long time. He has missed the entire offseason, including the preseason games. […] The post Severe Warning Issued Over Technique Putting Patrick Mahomes at Risk appeared first on Gridiron Heroics.
Browns news: Deshaun Watson a team captain for Week 1
The Cleveland Browns and head coach Todd Monken have opted to deploy captains on a week-to-week basis this year, rather than instill season-long captains. The team is young and still trying to figure things out, and Monken believes there are more leaders on the team than just five. Monken will name two offensive, two defensive, and one special […] The post Browns news: Deshaun Watson a team captain for Week 1 appeared first on ClutchPoints.
Faculty Focus: Chris Erickson, College of Business
Chris Erickson has spent 40 years at NMSU as an economics professor, researcher and mentor. Erickson, a professor in the Department of Economics, Applied Statistics and International Business in...
Report: Red Wings Still Without GM as Camp Nears
Detroit still has no general manager, and Shawn Horcoff took the NHL's GM call. #RedWings
Arsenal youngster in international tug-of-war
Ceadach O’Neill’s international future remains unresolved, with Northern Ireland and the Republic of Ireland both still possible options for the Arsenal youngster.Photo by Cameron Smith/Getty Imag...
Russell Peters opens up about race, politics and why he still needs comedy
Russell Peters talks race, prejudice, politics, and why making people laugh still matters.
Detroit’s iconic Hotel Yorba has a new owner whose plans are still in flux
The new owner said he had originally planned on an affordable housing conversion but has gone "back to the drawing board" after a meeting with nearby residents.
Why Lewis Dunk Is STILL Brighton's Most Underrated Player
The veteran skipper remains the common denominator in Brighton’s success, transforming raw defensive partners into stars while proving he is the timeless heartbeat of the Seagulls’ backline.
Scientists Are Still Trying To Understand How the Moon Formed
The Earth and the Moon have nearly identical isotopic compositions, and the Giant Impact Hypothesis strives to explain this. New research into the ancient impact shows how the temperature of both worlds, and how it affects the strength of the materials involved in the collision, shaped the outcome, including the isotopic compositions.
Youth with CF on approved treatment still face mental health issues
Youth with cystic fibrosis continue to experience mental and behavioral health concerns despite treatment with Trikafta, according to a study.
Valheim 1.0 Launches After 5 Years in Early Access
Valheim launched into Steam Early Access in February 2021 and quickly garnered attention, launching with over 500,000 peak concurrent players on Steam and still counting over 20,000 daily concurrent players at the time of writing. Now, over five years after the Early Access launch, the open-world...
Scotland defender Souttar may leave Rangers soon
John Souttar may yet leave Rangers in the short term, even though the transfer window has closed in Scotland. The Scotland defender, 29, is under contract until next summer. "I think he still can [make a contribution]," said Rangers manager Derek McInnes.
William Shatner reveals truth behind 'Star Trek' Tribbles scene, sliding doors
LOS ANGELES ― While still helming the U.S.S. Enterprise as rugged Captain James T.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
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Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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