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Two Women Arrested in Millcreek Township Illicit Massage Business Raid - The Institute to Address Commercial Sexual Exploitation
On June 16, law enforcement executed a search warrant on Magic Health Massage Spa in Millcreek Township in an ongoing effort targeting illicit massage businesses in Erie County. Law enforcement arrested two New York women who allegedly lived at the … Read more about Two Women Arrested in Millcreek Township Illicit Massage Business Raid »
Ecolab Closes CoolIT Acquisition and Expands AI Cooling Platform as Global High Tech Business Targets $4 Billion by 2030
ST. PAUL, Minn., July 02, 2026--Ecolab today announced the close of its acquisition of CoolIT Systems, a leader in direct liquid cooling for high‑density data centers. The transaction closed earlier than expected, and Ecolab welcomes the world-class CoolIT team to the company.
A new attack uses a BioShock-style puzzle to convince AI browsers they're not in the real world
Researchers from LayerX recently unveiled BioShocking, a new type of vulnerability designed to target AI-powered browsers capable of executing autonomous tasks on the open web. The security...
Rhode Island Marijuana Officials Ask Judge To Remove Block On Business Licenses Now That Rules Targeted By Lawsuit Have Changed
“We’re hopeful that once we get the go-ahead with the appropriate people that we can get the process moving again.” By Christopher Shea, Rhode Island Current Now that Rhode Island has eliminated the residency requirement for recreational pot shop owners, the state’s Cannabis Control Commission is asking a federal judge to undo the court order […]
Marshall Health Network first in West Virginia to offer histotripsy treatment for liver tumors
HUNTINGTON, W.Va. – Marshall Health Network–Cabell Huntington Hospital (CHH) is the first hospital in West Virginia to treat liver tumors using the Edison® Histotripsy System, giving patients access to an advanced treatment that targets tumors with focused sound waves instead of surgery, chemotherapy or radiation. The Edison Histotripsy System uses image-guided sonic beam therapy to precisely target […]
Securing America’s 250: Law enforcement faces shifting plans and World Cup demands
The day after the White House kicked off celebrations for America’s 250th birthday with a UFC fight on the South Lawn, FBI Director Kash Patel announced that law enforcement had thwarted a plot to attack the event using drones and snipers to target Trump and others.
M&A is ‘on fire’ as large-cap firms simplify, Citi U.K. CEO says
Citi U.K. CEO Tiina Lee said U.K. M&A is “on fire” as companies simplify and overseas buyers target British assets.
DeSantis announces plans to use new state law to target dozens of alleged terrorist groups
Florida Gov. Ron DeSantis designated more than 90 groups as terrorist organizations under a new state law, including CAIR, Muslim Brotherhood and Antifa.
Apple to launch 5 new iPhone models to gain market share amid memory crunch
Company raises production target for first foldable phone to about 10 million units
NC lawmakers send bills targeting gangs, mental health evaluations to Stein
The House of Representatives on Wednesday passed two bills targeting criminal suspects: one would change where they are evaluated for mental illness while the other would give prosecutors stronger tools to crack down on gang activity.
Ex-CIA Director John Brennan sues the Trump administration, demanding it preserve records of investigations into him
Former CIA Director John Brennan sued the Trump administration Wednesday, demanding a court order that would require officials to preserve records from investigations that he says are targeting him for “what amounts to phantom criminal conduct.”
Alabama target, top cornerback reportedly makes commitment decision
Top cornerback prospect Hayden Stepp has reportedly announced a commitment between Alabama, California, and Oregon.
Soros network targets deep-red Mississippi in bid to flip Senate seat
Scott Colom challenges Sen. Cindy Hyde-Smith in deep-red Mississippi and is backed by George Soros' top advisor and Sen. Elizabeth Warren.
Marketers pivot to TikTok, YouTube to target Gen Z shoppers
Top marketers are shifting their platform priorities to target Gen Z and Gen Alpha. They are using Pinterest, YouTube, AI tools, and other methods.
Primer: 2 elite Michigan Football recruiting targets ready to commit
Decision day is here for 2 of Michigan Football’s top targets, including 5-star CB Joshua Dobson. We have that and more in today’s Recruiting Roundup:
Lawmakers must put women’s health, dignity and lives ahead of politics
Each year since the fall of Roe, the Louisiana Legislature has advanced increasingly aggressive versions of the state's abortion ban, often under the guise of targeting bad actors.
Lawmakers must put women’s health, dignity and lives ahead of politics
Each year since the fall of Roe, the Louisiana Legislature has advanced increasingly aggressive versions of the state's abortion ban, often under the guise of targeting bad actors.
Around the Empire: Aaron Judge targeting August return
Yankees provide Judge return timetable; Fried throws first sim game; Cruz called up; Jazz clears concussion protocol
Richmond mental health agency operator charged in $49.6M Medicaid fraud scheme
The operator of a Richmond mental health agency faces federal charges after prosecutors say she ran a years-long Medicaid fraud scheme that targeted low-income and homeless Virginians.
Anthropic unveils drug discovery plans alongside Claude Science, an AI tool for drugmakers
At an event on Tuesday, the AI heavyweight said it plans to target "neglected" diseases.
With Claude Science, Anthropic Targets Another Application
Anthropic is targeting the science vertical with a new AI workbench.
Basecamp Research brings EDEN's antibiotic and vaccine design models to Claude Science
/PRNewswire/ -- Basecamp Research today announced that its antibiotic design and vaccine target prediction EDEN models are now available through Claude,...
Oracle E-Business Suite Payments flaw under attack (CVE-2026-46817)
Exploitation attempts targeting a vulnerability (CVE-2026-46817) in Oracle's E-Business Suite's Oracle Payments module have been spotted.
Teen pregnancy prevention cuts hit Wisconsin program connecting health providers and teens
Federal officials have cut off more than $2.4 million in federal funds for 2026-27 and 2027-28 targeting teen pregnancy prevention that would have gone to the Wisconsin health department, according to federal records. The funds would have gone to a variety of nonprofits and agencies in counties with the highest rates of pregnancy and sexually […]
China's Xiaomi, Oppo, Vivo cut 2026 smartphone targets again: sources
Rising costs and component shortages lead some brands to slash outlook by up to 30%
Trump demands gas stations lower pump prices immediately and renews push for $2.50 gasoline
President Trump demands gas station owners drop fuel prices immediately, targeting $2.50 a gallon and warning of consequences for price gouging.
Gallego spokesperson says Trump is ‘targeting’ the Democratic senator with DOJ investigation
A spokesperson for Sen. Ruben Gallego said Monday that President Donald Trump is “targeting” the Arizona Democrat with a Justice Department investigation into his campaign finances.
What to Expect: Commercial Mission to Boost NASA’s Swift
A mission to boost the orbit of NASA’s Swift observatory is targeted to launch no earlier than Tuesday, June 30, at 10:17 p.m. UTC+12 (6:17 a.m. EDT).
Socialists take fight west, target Colorado in latest bid to oust Democratic Party establishment
Democratic Socialists of America target Colorado primaries as DSA-backed Melat Kiros challenges Rep. Diana DeGette in Denver's 1st Congressional District.
A New Playbook: State-Driven Solutions for Resilient Health Data
Health equity depends on data equity: the representation of communities in the data used to identify disparities, target interventions, and hold systems accountable.
AI is rewriting the political competitive landscape
Artificial intelligence is rapidly becoming a central infrastructure layer in political campaigns, reshaping how elections are financed, contested and influenced, The New York Times reports. Campaigns and affiliated political groups are increasingly investing in AI-driven tools for voter targeting, message optimization and large-scale content generation, turning modern elections into capital-intensive, technology-enabled competition. This shift is […]
Thomas, Gorsuch target landmark ruling Trump says protects the 'fake news'
Clarence Thomas and Neil Gorsuch call for overruling New York Times v. Sullivan in their dissent over the CNN-Dershowitz defamation decision.
Target Seems To Be Artificially Increasing Prices On Pokémon TCG
Why let scalpers get all the extra cash?
Lizzo slams 'Khia Asylum' meme for 'flopping' pop stars: 'Weapon that targets only women'
Lizzo slammed the 'Khia Asylum' meme often use for 'flopping' pop stars: 'A tool to bully artists,' she said, calling the title itself 'backhanded' for mocking a 'pillar in the Black community.'
How a Brain Messenger Protein Drives Progression of Alzheimer’s Disease
In mice, a brain protein called Arc helps spread toxic molecules from sick brain cells to healthy ones. If therapies could be designed to target the spread, they could be a powerful tool to stop disease progression.
Apple Plans Wider Color Gamut for Future MacBook Pro, iMac, and iPad Pro
Apple plans to adopt OLED panels capable of displaying a much wider range of colors, according to a new report from research firm TrendForce. The new panels would cover 95% of the BT.2020 color standard, which describes a far broader spectrum of colors than the DCI-P3 standard Apple's screens currently target. In practice, that means deeper, more accurate reds, greens, and blues.
Liverpool transfer news: Bradley Barcola among alternative targets with PSG in talks to sign Yan Diomande
Liverpool target Yan Diomande has indicated his desire to join Paris Saint-Germain; PSG winger Bradley Barcola features highly among options Reds are considering as an alternative; Barcolas PSG future is uncertain due to frustrations about being overlooked for selection in big games
Grand Theft Auto VI Rumored to Offer 60 FPS Mode on PS5/Xbox Series X, But Maybe Not at Launch
One of the reasons Grand Theft Auto VI fans are eager to learn the currently missing details on PS5 Pro enhancements is that the most powerful console available on the market is expected to include a performance mode targeting 60 FPS. However, according to a credible source, there's a decent chance that even the base PlayStation 5 and Microsoft's roughly equivalent Xbox Series X will support 60 FPS in Rockstar's massively anticipated game. The rumor comes from the popular Polish gaming podcast Rock and Borys, which features Remigiusz "Rock" Maciaszek and Borys Nieśpielak. It is the latter who shared in […]
Warriors are reportedly targeting Anthony Davis to lure LeBron James
The Warriors reportedly have a very ambitious plan to try to land LeBron James in free agency.
What’s Open, What’s Closed: Big changes for a few businesses, while chains add Denton County locations
Harvest House and Flowergarden118 find new ownership. The Chestnut Tree Tearoom & Bistro and Fiesta Eats Hub close. Target, Bath & Body Works and Panda Express open new locations in
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Top Longhorns OL target moving up commitment date?
Texas recruiting has been red hot and it seems set to continue. Ismael Camara, five-star OL, might be moving his timeline and Texas is trending.
Then and Now: Brandenburg manages through global uncertainty
For James Brandenburg, president of U.S. operations for JVS Export, a family-owned textile manufacturer headquartered in India, the hardest part of his job isn’t selling home textiles to Walmart, Target...
Three Atlanta Hawks Center Trade Targets to Watch This Offseason
The Atlanta Hawks drafted two big men but may not be done at center. Here are three Hawks center trade targets to watch this offseason.
Democrats Wrestle With Race, Populism and Ideology in Clashes With Lawmakers of Color
WASHINGTON (AP) — After democratic socialist Claire Valdez defeated an establishment-backed candidate in New York's congressional primary last week, her elated supporters quickly turned their attention to a new target. “You're next!” they chanted when an image of House Democratic leader Hakeem ...
Maine targets three initiatives for initial use of federal rural health funds
The Mills administration says it's decided how it will spend nearly half of the $190 million it's received this year through the federal Rural Health Transformation Fund.
Bernstein Says Life Science Sector is Improving, Resumes Thermo Fisher Scientific (TMO) Coverage
Thermo Fisher Scientific Inc. (NYSE:TMO) is included among Billionaire Steven Cohen’s Top 11 Dividend Stock Picks. On June 26, Bernstein resumed coverage of Thermo Fisher Scientific Inc. (NYSE:TMO) with a Market Perform rating. It also set a $520 price target after the analyst returned from maternity leave. In a research note, the firm said “Many […]
Private Selection chicken breast product target of health alert
The U.S. Department of Agriculture wants people who may have purchased a variety of Private Selection raw boneless chicken breasts to check their freezers or refrigerators in case they still have them.
Private Selection chicken breast product target of health alert
The U.S. Department of Agriculture wants people who may have purchased a variety of Private Selection raw boneless chicken breasts to check their freezers or refrigerators in case they still have them.
Game 84: Rockies at Twins
First Pitch: 6:10 pm CDTTV: Twins.TVRadio: TIBN / WCCO 830 / The Wolf 102.9 FM / Audacy One night after what many are already calling the dumbest game of all time, Target Field is playing host to the Battle of the Mikes. Mike check, one-two, one-two. Heh. Hilarious. For the Twins, it’s Mike Paredes, who has […]
States seek to lower drug prices by targeting the companies that manage them for health plans
TOPEKA, Kan. — As consumers worry about medication costs, states are trying to lower drug prices by reining in big companies that oversee prescription coverage for health insurers. Some of those companies, called pharmacy benefit managers, also own pharmacies, and one of them, CVS, has spent millions of dollars fighting
Starz Entertainment (STRZ) Stock Sees Fair Value Lift After Q1 Analyst Target Increases
Price targets for Starz Entertainment have shifted as the analyst fair value estimate moved from US$19.38 to US$28.50, putting a higher reference point in focus for investors tracking the stock. Recent Street research has turned more constructive after the Q1 report, with several firms lifting price targets and updating models to reflect how they now view execution risks and valuation support. In the sections that follow, you will see how to interpret these changing targets and what they...
Is 10,000 Steps a Day Actually Based on Science? Here's What the Research Says
The 10,000 steps target came from a 1960s Japanese marketing campaign, not clinical research. Here's what the evidence actually supports about daily step counts, mortality risk, and what a realistic goal looks like for most people.
Caesars Entertainment (CZR) Expands In Maine Online Gaming, Is The Stock Already Fully Valued?
Caesars Entertainment expands digital footprint with Wabanaki Nations partnership Caesars Entertainment (CZR) is extending its partnership with three Wabanaki Nations to include online casino gaming in Maine, targeting a potential 2026 iGaming launch, subject to regulatory approvals. See our latest analysis for Caesars Entertainment. Caesars Entertainment shares have climbed over recent months, with a 90 day share price return of 16.79% and year to date gain of 28.14%. However, the 5 year...
Sky Sports: Everton are in the race to sign Serie A midfielder
Everton Transfer News: Mandela Keita Emerges as Midfield TargetEverton continue to search for midfield reinforcements this summer, with Sky Sports reporting that Parma’s Mandela Keita has emerged as...
Scientists discover what triggers belly fat as we age
Aging may trigger the appearance of specialized stem cells that supercharge the body's ability to create new belly fat. The discovery reveals a potential biological driver of middle-age weight gain and a promising target for future anti-obesity treatments.
US Army commander used drones, C4-packed robots to clear breach
A recent drill saw dozens of drones targeting enemy weapons, sensors, and positions before soldiers attempted to approach.
If a Lyme disease vaccine gets approved, how would it go over? We asked hunters
Drugmakers are working on a potential new shot to prevent the tick-borne illness. How might it fare in the era of vaccine skepticism?
States seek to lower drug prices by targeting the companies that manage them for health plans
Legislators across the U.S. are trying to lower prescription costs by reining in big companies that handle drug coverage for health insurers.
States seek to lower drug prices by targeting the companies that manage them for health plans
Legislators across the U.S. are trying to lower prescription costs by reining in big companies that handle drug coverage for health insurers.
Pete Buttigieg was briefly separated from his children after police say he was target of false report
Former Transportation Secretary Pete Buttigieg was the target of an anonymous report that police determined was false and that he says forced him to spend a night away from his four-year-old twins.
Roy Cooper brings 'Make Stuff Cost Less' tour to Asheville, targets health costs, tariffs
Former North Carolina Governor and U.S. Senate candidate Roy Cooper brought his "Make Stuff Cost Less" tour to Asheville on Friday.
Colonial Market owner closes south Minneapolis location due to sharp drop in business following Metro Surge
Colonial Market owner Daniel Hernandez has closed the chain’s south Minneapolis location, which he said never recovered after the store’s employees and customers were targeted during Operation Metro Surge.
JD Vance says Nixon’s Watergate scandal would be ‘12-hour news story’ today
Vice-president declares admiration for 37th president and claims Nixon and Trump targeted by ‘deep state’ forces
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Target rolls out new attendance tracking system for workers
Target's new point-based attendance tracking system rolls out in the coming months, the latest of several changes aimed at improving store operations.
5 states targeting Medicaid behavioral health enrollment amid fraud concerns
At least five states have taken steps in 2026 to restrict new Medicaid behavioral health provider enrollments as stakeholders seek to curb fraud, waste and abuse while strengthening oversight of high-risk services. The developments come as the Trump administration aims to crack down on healthcare fraud. On June 25, the Justice Department charged 455 people, […]
We're trimming a health-care stock into strength and raising our price target
It's been a remarkable turnaround for a name we started to buy a little too high and a little too fast when the Iran war broke out.
Walmart Business Targets the Invisible Work Slowing Small Business Down
Running a small business can take up a big chunk of its owner’s time. Even something as simple as ordering the breakroom snacks each month can add up, and
Imaging-related burdens may be keeping some from completing cancer screenings
Targeted interventions could help reduce pre-test anxiety, improve the physical screening experience, and address structural barriers in underserved settings.
Betts homers for No. 300, Ohtani dominates after early trouble
MINNEAPOLIS — For a brief moment Wednesday night at Target Field, Shohei Ohtani looked vulnerable.
Family towing business forced to start from scratch after theft
Thieves targeted a DeKalb County small business last Thursday, resulting in a devastating tow truck theft that impacts daily operations.
Pistons reportedly wanted Lakers star Austin Reaves, but missed out
A potential Detroit Pistons target in free agency is officially off of the board, as Austin Reaves has re-signed with the Lakers.
Top supplements Americans use are shifting from multivitamins to targeted health fixes
Dietary supplements are an excellent way to fill gaps in our nutritional requirements. From vitamins and macronutrients to gut-health probiotics, dietary supplements have helped people address deficiencies. ...
FSU computational scientist helps advance targeted drug-delivery systems using coding, modeling
A Florida State University computational scientist is paving the way for future medical breakthroughs by developing mathematical models and simulations to
Foldable iPhone 'Ultra' Set for Production in July Despite Hinge Issues
Apple's rumored foldable iPhone "Ultra" is expected to begin mass production at the end of July, according to a new report by The Elec. Although some recent reports suggested the book-style device could be delayed due to hinge-related issues, the Korean outlet's sources indicate that Apple is still targeting a September launch as planned.
Hollister’s First-Ever Target Collection Reveals a 3-Step Growth Strategy Any Business Can Copy
Hollister's first home collection is a move from closet share to lifestyle share, and a growth playbook any founder can borrow.
New York Giants' Newest Suggested Target Makes Zero Sense
The New York Giants should absolutely not pursue this player.
Dave And Buster's Entertainment (PLAY) Stock Sees Fair Value Cut After Q1 Analyst Revisions
The fair value estimate for Dave & Buster's Entertainment has been revised from US$18.88 to US$17.00, bringing the price target closer to updated assumptions on comparable sales and earnings. Analysts link this adjustment to a balance of cautious near term expectations after Q1 and ongoing optimism that longer term changes in the business could still support the story if execution improves. Read on to see how this evolving narrative might shape how you track Dave & Buster's Entertainment from...
Report: Pacers Targeting Guard in Second Round of NBA Draft
The Indiana Pacers are reportedly targeting an intriguing guard in the second round of the 2026 NBA Draft.
Buffalo Bills Should Still Target These 3 Playmakers for Josh Allen
Even with the NFL offseason coming close to an end, the Buffalo Bills should look to add one of these three playmakers for Josh Allen.
Gambo: Suns interested in Joshua Jefferson, Baba Miller and others
The Phoenix Suns have targeted a group of six players they would select in the second round of the 2026 NBA Draft, according to John Gambadoro.
Urban League targets business growth with new Ascension-St. James training cohort
The Urban League of Louisiana is expanding its entrepreneurial development efforts in Ascension and St. James parishes through a new cohort of its Scale Up! Louisiana program, designed to help established small businesses grow and become more profitable. Wednesday is the last day to sign up for the summer 2026 cohort, which will run from […]
Brooklyn coffee shop that targeted Jewish congressman faces DOJ probe after reported tax, health code issues
Poetica Coffee owner Parviz Mukhamadkulov donated to scandal-plagued candidate Graham Platner and reportedly faces tax debts and health code violations.
Uber lawsuit targets CEO, board over driver assault claims
Uber faces a lawsuit alleging CEO Dara Khosrowshahi and the board mishandled sexual assault claims.
AI’s money machine faces first real test in Manhattan primary
Industry spends millions to target candidate who supports greater regulation of the technology
BMO Lowers Expectations After Dave & Buster’s Entertainment, Inc. (PLAY)’s EBITDA Miss
Dave & Buster’s Entertainment, Inc. (NASDAQ:PLAY) is among the best low priced stocks to get rich in 2026. Andrew Strelzik, an analyst at BMO Capital, trimmed the price target on Dave & Buster’s Entertainment, Inc. (NASDAQ:PLAY) to $22 from $24 on June 16. As highlighted by the analyst, the company’s Q1 EBITDA missed consensus by […]
These 3 Kenvue brands target common skin problems through science
Neutrogena®, Aveeno® and Lubriderm® each offer science-backed solutions to common skin issues.
Quantum Computing Stocks Gain On Trump Executive Orders, 2028 Target
Quantum computing stocks rose after President Trump signed two executive orders aimed at strengthening the U.S. quantum computing ecosystem.
2026 NHL Draft: Defensemen targets for the Penguins
Piggybacking off the earlier look into the forwards that could make sense for the Penguins to consider with the 22nd pick in Friday’s NHL draft, let’s take a turn to the blueline. Be it coincidence or preference, Kyle Dubas has only drafted one defenseman in the first round since he became a general manager in […]
A potential Lakers center target is apparently off the table
A rim-running, defensive-minded center who has been linked to the Lakers just got traded to another team.
MOSH Co-Founded by Maria Shriver and Patrick Schwarzenegger
Go Behind the Brand with Maria Shriver, co-founder of MOSH.
Uber's stake in Lime's IPO shows potential payday, business strategy
Uber is Lime's largest shareholder with a 24% stake. The scooter company filed plans for an IPO, targeting a price of $24 to $26 per share.
Trump-backed housing overhaul targeting Wall Street investors clears Senate
The Senate advanced the 21st Century Road to Housing Act, a Trump-backed package aimed at preventing the U.S. from becoming a "nation of renters."
Fantasy baseball Week 14: Elly De La Cruz returns, Bobby Witt injury concerns grow, waiver targets emerge
Elly De La Cruz returns as Bobby Witt battles injury and Jac Caglianone stays hot
Breaking Business News: AbbVie To Acquire Apogee Therapeutics
AbbVie is set to acquire Apogee Therapeutics and its pipeline of multiple clinical-stage candidates in development across inflammatory and immunological diseases, including its lead asset, zumilokibart (APG777), a subcutaneous half-life extended monoclonal antibody targeting interleukin (IL)-13 in atopic dermatitis (AD). Under the terms of the transaction, AbbVie will acquire all outstanding shares of Apogee for $135.11 per share in cash. […]
How to stop scam texts from targeting aging parents
Learn how to protect elderly parents with dementia from scam texts by using iPhone Screen Time limits, carrier tools and payment restrictions.
“Criminal Approach to Politics”: Trump Ally Abelardo de la Espriella Wins Colombian Presidency
Right-wing Trump ally Abelardo de la Espriella has clinched a narrow victory in Sunday’s runoff presidential election in Colombia, defeating leftist Senator Iván Cepeda, an ally of current President Gustavo Petro. De la Espriella ran a fearmongering, “tough-on-crime” campaign, promising to build mega-prisons inspired by El Salvador’s authoritarian President Nayib Bukele, to bomb “narcoterrorist camps” and to abandon Petro’s peace efforts. His reported victory is also a win for U.S. President Donald Trump, whose administration is waging an intensifying “war on drugs” across Latin America, targeting left-wing leaders like Petro with false allegations and threats of military intervention. “De la Espriella clearly represents a criminal approach to politics: lying, propaganda, coordination and collusion with criminal narcotrafficking, restriction of rights, and money laundering,” says longtime Colombian activist Manuel Rozental. With his victory, says Rozental, “We expect to have military operations and a U.S. intervention within the country. We expect to have human rights abuses. We expect to have militarization. And it’s all for the extraction of resources and the link of drug trafficking to the U.S. government, U.S. interests and global mafia.”