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Kings' Veterans Praise Rookie Acuff After 33-Point Showing
The Sacramento Kings are yet to get a win, but Darius Acuff Jr. looks like the high-octane guard that the franchise so desperately needs. Coming off a 33-point outburst, how will Acuff play against the Memphis Grizzlies?
Texas opens as heavy favorite against Mississippi State
The Longhorns are three-score favorite as they welcome the Bulldogs to Austin.
MTSU named among Billboard's Top Music Business Schools for 12th year in a row
Middle Tennessee State University has been named a top music business school by Billboard for the 12th year in a row.MTSU's Department of Recording Industry mad
3 comments | Progressive Democrats are closely watching four Senate...
Progressive Democrats are closely watching four Senate races in the upcoming midterm elections. Our politics reporter Kellen Browning explains why.
Political cartoons for October 25
Sunday's political cartoons include increasing costs, the White House briefing room, and more
2 political experts question Chicago Mayor Brandon Johnson's tax proposals for 2027 budget
Game Time Thread: Juventus vs. Lecce
MATCH INFO When: Sunday, Oct. 25, 2026. Where: Stadio Via del Mare, Lecce, Italy. Official kickoff time: 6 p.m. local time in Italy and across Europe, 8 p.m. in the United Kingdom, 1 p.m. Eastern time, 12 p.m. Central time, 10 a.m. Pacific time. (Please note that the fall time change in Italy goes into effect on Sunday, […]
Packers Lose Defensive Captain Just Before Massive Showdown With Lions
Green Bay Packers defensive captain Zaire Franklin has been ruled out against the Detroit Lions, leaving Green Bay without both starting linebackers.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
During the hike, participants wore military short-shorts known as “silkies” as part of the event’s tradition to foster connection.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
Veterans, active military service members and community supporters recently gathered for a hike organized by a nonprofit dedicated to suicide prevention.
Jennifer Hawks explains why she should be California's State Treasurer
Jennifer Hawks, a candidate for California state treasurer, shared her qualifications and vision for the office in an interview on California Politics 360.
Timeline of the Capitol Annex project
Ashley Zavala looked back at the decade-long process of building the new offices for the governor and state lawmakers.
South Texas Health System (@stxhealthsystem)
1 likes, 1 comments - stxhealthsystem on October 25, 2026: "Exceptional Care Starts With You: Nurses play a vital role in every patient journey, providing the compassionate, skilled care that helps make South Texas Health System’s 12 facilities a trusted healthcare resource for communities across the Rio Grande Valley. If you're passionate about making a difference and delivering exceptional patient care, now is your opportunity to join the largest integrated healthcare network in the region. STHS is seeking dedicated and compassionate registered nurses to join its team at four acute care hospitals, a behavioral health hospital and seven freestanding emergency departments. Become part of a team committed to clinical excellence, collaboration and compassionate care. To view current openings and apply, visit the STHS careers page at the link in our bio.".
GO Health asks families to be lead-aware
BATAVIA — Area health departments are encouraging families to get the facts and get their children and homes tested for National Lead Poisoning Prevention Week.
Rep. Haley Stevens sidesteps whether she still supports El-Sayed, criticizes outreach to Black voters
Evaluating DJ Herz After Bouncing Back from Injury with Nationals
After making his first MLB appearance in nearly two years, what should the Washington Nationals expect from DJ Herz in his third season with the organization?
Aaron Rodgers throws 540th career touchdown, passing Peyton Manning on all-time list
Aaron Rodgers now sits third all-time in passing touchdowns.
Scientists Find Chronic Back Pain Activates a Brain Network Linked to Personal Identity
A new UC San Diego brain imaging study involving 114 adults suggests that chronic back pain flare-ups affect brain networks involved in self-reflection and personal memories. The findings may help exp...
Aaron Rodgers passes Peyton Manning on all-time touchdowns list
Aaron Rodgers surpasses Peyton Manning in all-time touchdown passes.
Babcock Singles Out Oiler After Ugly Loss To Maple Leafs.
Mike Babcock called out one player in particular after a 7 - 2 thrashing against the Leafs.
October 7 should have changed Israeli politics, yet we are voting for the same leaders
Israel deserves more than another election between yesterday’s failures. It deserves a new beginning.
Mavericks 'Very, Very Confident' in Rookie PG Behind Kyrie Irving
Spanish sensation Sergio de Larrea shined with 21 points against San Antonio, proving he can anchor the rotation while Dallas carefully manages Kyrie Irving’s heavy workload.
10 Thoughts From Watching Others Sweat It Out
Back during the very lean years of the Ray Goff era in Athens, a certain revered columnist for the Macon Telegraph joked in a weekly prediction column that Georgia would lose to “Open” during its upcoming bye week. Thankfully, those years have passed by, and the outlook for Georgia during open weeks for what is […]
Instacart Stock What Health Benefits Deal And $5 Million Settlement Mean
Instacart parent Maplebear has agreed to a US$5,000,000 settlement with U.S. authorities over past PERM hiring practices and has been selected by True Rx Health Strategists to power an employer funded healthy food benefit through Instacart Health Fresh Funds starting in 2027. The True Rx program positions Instacart within pharmacy benefit design and ties employer spend directly to clinically supervised food choices. The settlement adds compliance obligations, policy changes and monitoring...
After long, strange trip, Compass CEO nears launch of psilocybin pill
Compass Pathways is on the cusp of FDA approval for a proprietary version of psilocybin — the active drug in magic mushrooms.
Michigan's Jason Beck promised change, but numbers tell another story
Michigan football vowed to fix its perimeter run game or stop it, but the team continues to struggle on the edge.
Inside California Politics: State Senate candidate John Erickson
(Inside California Politics) — California’s top-two primary system often leads to same-party general election races, often between two Democrats, and this year is no exception. Two weeks ago on Inside...
31 'Brooklyn Nine-Nine' Memes That Would Win a Halloween Heist and Become the Ultimate Detective/Genius
These memes are noice!
Manchester United vs Bournemouth: Live updates from Old Trafford
Under-fire Manchester United manager Michael Carrick is under enormous pressure heading into today’s Premier League clash with Bournemouth on the back of a seven-game run without a win.The boss has ...
Nick Nurse: “Jaylen Brown is obviously very good. He …
Nick Nurse: “Jaylen Brown is obviously very good. He …
Maliek Collins agrees to terms on contract extension
Maliek Collins to remain in Cleveland for two additional years
Hints About Why Sabres Missed Connor Hellebuyck
The fact that the Buffalo Sabres missed out on Connor Hellebuyck could linger painfully for a while if the goalie play in Western New York doesn’t improve in a hurry. It’ll hurt all the more because the reports over the summer indicated that for at least a time, the Sabres were the frontrunners to pull […] The post Hints About Why Sabres Missed Connor Hellebuyck appeared first on HEAVY.
Former Coach Urges Vikings to Blow Up Kyler Murray Experiment; Trade for… Kirk Cousins?
Jon Gruden has an insane trade idea for the 5-0 Minnesota Vikings and involves a quarterback change that nobody would see coming...
Crystal Palace v Chelsea
Follow live text commentary, score updates and match stats from Crystal Palace vs Chelsea in the Women's Super League
Health board still paying for research despite criticism over patient benefit
Betsi Cadwaladr health board was due to pay Bangor University £110,686 for two researchers.
NFL Week 7 expert picks, score predictions: Packers at Lions
Green Bay Packers vs. Detroit Lions NFL Week 7 expert picks from the Pride of Detroit staff.
Saints vs. Steelers in Paris: Week 7 game chat
The Saints face the Steelers in this Week 7 matchup. Join us here for the game!
Argument over purchase turns physical; suspect pulls gun at South Side business
KABB Fox News 29 San Antonio provides local news, weather forecasts, traffic updates, investigations, notices of events and items of interest in the community, sports and entertainment programming for San Antonio and nearby towns and communities in South Central Texas, including Bandera, Boerne, Carrizo Springs, Castroville, Cibolo, Converse, Crystal City, Cuero, Del Rio, Devine, Eagle Pass, Floresville, Fredericksburg, Goliad, Helotes, Hondo, Kerrville, Live Oak, New Braunfels, Pearsall, Pleasanton, Poteet, Poth, Sabinal, San Marcos, Seguin, Schertz, Somerset, Universal City, Uvalde, Windcrest.
Argument over purchase turns physical; suspect pulls gun at South Side business
WOAI NBC News Channel 4 San Antonio provides local news, weather forecasts, traffic updates, investigations, and items of interest in the community, sports and entertainment programming for San Antonio and nearby towns and communities in South Central Texas, including Windcrest, Uvalde, Universal City, Somerset, Seguin, Schertz, San Marcos, Sabinal, Poth, Poteet, Pleasanton, Pearsall, New Braunfels, Live Oak, Kerrville, Hondo, Helotes, Goliad, Fredericksburg, Floresville, Eagle Pass, Devine, Del Rio, Cuero, Crystal City, Converse, Cibolo, Castroville, Carrizo Springs, Boerne, Bandera.
Appleton-area high school sports results for Saturday, Oct. 24
High school tennis, volleyball, soccer and cross-country teams were in action.
Colts vs. Vikings
Here is how the ColtsRoundtable staff sees the Week 7 matchup between the Indianapolis Colts and Minnesota Vikings unfolding.
Open Thread, Sunday, October 25: How we doing today, folks?
Your daily source for off topic chatter with the MMA Mania faithful.
How to build a police state
To understand where Trump is trying to take the US, we should look to the authoritarian playbook of his favorite ally: El Salvador’s Nayib Bukele
‘Wicker’ star Alexander Skarsgård says he’s ‘not very good with being earnest’
‘Wicker’ star Alexander Skarsgård says he’s ‘not very good with being earnest,’ which his latest role, as a sexy basket, required.
Adolph Reed on What It Will Take to Defeat Trumpism
Donald Trump’s popularity may be waning, but the political-economic conditions that gave rise to Trumpism remain, Adolph Reed argues. To defeat the Right, the Left needs to rebuild durable working-cla...
‘Dream big’: The Seattle-area kids and teens launching businesses
Some among the Seattle area's Generation Z and Alpha age groups are diving headfirst into entrepreneurship.
Browns QB Shedeur Sanders Pegged for Deadline Exit
The Browns are approaching a quarterback decision that could reshape their roster before the trade deadline. The post Browns QB Shedeur Sanders Pegged for Deadline Exit appeared first on HEAVY.
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race
President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day.
Steelers Get Good News on Rico Dowdle
Pittsburgh Steelers running back Rico Dowdle (knee) is active for Sunday’s game against the New Orleans Saints in Paris after […]
NVIDIA's open-source path tracer gets 20% faster with RTXPT 1.9
NVIDIA's open-source path tracer now supports up to 2 million lights, SHaRC caching by default and Windows ARM64, alongside multiple rendering optimizations.
Sources: Leeds hit by new hurdle in Nicolo Tresoldi race
Daniel Farke in a press conference with Leeds, with Paraag Marathe at Elland Road
Business Ins and Outs | Atlanta dessert shop, Provisions, Mexirican and donut shop opening
Business Ins and Outs | Atlanta dessert shop, Provisions, Mexirican and donut shop opening
Week 7 inactives for Saints
New Orleans declares seven players inactive versus Pittsburgh
What analysts are watching in the Texas Senate race, CBS News political experts weigh in
Utah Jazz Must Let Darryn Peterson Feel the Pressure
Shielding Utah’s prized rookie from high-stakes moments only stunts his growth. To secure their future, the Jazz must force Darryn Peterson to embrace the game-deciding pressure now.
Texas A&M Defense Folds Again As Alabama Exposes Aggies In Late Collapse
Texas A&M's defense surrendered 311 passing yards and two fourth-quarter touchdowns in a 31-20 loss to Alabama, raising more questions about Mike Elko's Aggies.
Patriots rooting guide for NFL Week 7
Rooting information, kickoff times, TV schedule and more for NFL Week 7.
Giants at Texans: How to watch, TV schedule, and more
Wanna watch a Texans game? We can help you with that.
Five new businesses coming to Hunt Valley Exchange, including Dunkin’ and indoor golf simulator
Five businesses are coming to Hunt Valley Exchange in northern Baltimore County, including a Dunkin’, indoor golf simulator studio, Indian restaurant and wine and spirits store.
Memorial Health dietitian highlights importance of blood sugar management
Zeff encourages people to schedule regular medical appointments and get their blood sugar tested, particularly those with a family history of diabetes.
South Texas Health System (@stxhealthsystem)
2 likes, 1 comments - stxhealthsystem on October 25, 2026: "One Last Chance to Think Pink: Breast cancer remains the most common cancer among women after skin cancer, making routine screenings and early detection more important than ever. Mammograms can help identify breast cancer before symptoms appear, when treatment options may be most effective. Last week, South Texas Health System McAllen celebrated breast health and preventive care with a special Mammo Monday event featuring the vibrant sounds of mariachi music at the hospital’s main entrance. The celebration reflected STHS' ongoing commitment to encouraging women to prioritize their health through regular screenings. Now, there’s one final Mammo Monday remaining! Join us at STHS ER Mission on October 26 from 8 a.m. to 5 p.m. for the last breast cancer event of 2026. During the event, attendees can: 🎀 Learn about breast cancer screening options 🎀 Schedule a mammogram appointment 🎀 Receive a complimentary goodie bag while supplies last To help make preventive care more accessible, South Texas Health System is also offering reduced self-pay rates* throughout October: • 2D Mammogram: $100 • 3D Mammogram: $155 • Bone Density Screening: $160 A screening today could make all the difference tomorrow. Make your health a priority and encourage the women you love to do the same. For breast health resources and information on the Think Pink campaign, visit the link in our bio. *If not already a covered benefit of your insurance.".
I'm a Dietitian, and This Is What I Tell People Who Drink Diet Soda Every Day
A registered dietitian explains what the research says about diet soda and artificial sweeteners, from weight and blood sugar to gut and heart health.
Women's FA Cup clash against Rotherham United postponed
Following a pitch inspection at the BD Community Stadium, this afternoon's First Round Women's FA Cup clash between Leeds United Women and Rotherham United Women has been postponed.An update on the re...
Sarkozy's son warns violent protests in France could worsen amid political unrest
Louis Sarkozy, son of former French President Nicolas Sarkozy, discusses violent unrest in France, the influence of far-left groups and the country’s immigration and economic challenges.
The top 25 modern golf courses in Canada, ranked
Our ranking of top modern Canadian courses returns, with Nos. 1 and 2 sitting side by side.
CBS News political experts weigh in on Texas Senate race halfway through early voting
The latest CBS News poll showed Talarico leading 51% to 49%, well within the margin for error.
New York Giants' Never-Ending Nightmare Might Get Even Worse
Things just keep getting worse for the New York Giants.
Marcos Leonardo Opens Up On A Difficult Start At Ajax
Following Ajax's win against Atalanta, Marcos Leonardo spoke about a difficult start at Ajax.
Paris Pressure: Saints Must Block Out the Chaos and Finish Their Business Against the Steelers
Franciscan Health, Tonn and Blank Plan Michigan City Medical Office Building at Former Marquette Mall
Franciscan Health, in partnership with Tonn and Blank Construction, is planning a medical office building on a portion of the former Marquette Mall property. Franciscan Health plans to operate a …
Turnovers continue to plague the Cavs in the fourth quarter
“There’s no excuses, but we are working on it,”
New York Giants activate Paulson Adebo; elevate Jalin Hyatt
The New York Giants have made a series of roster moves, including the activation of CB Paulson Adebo and the elevation of WR Jalin Hyatt.
Green Bay Packers vs. Detroit Lions: How to watch the NFL Week 7 game, channel, streaming info and more
Real Madrid boss Jose Mourinho sends DEFIANT Lamine Yamal message ahead of El Clasico
Real Madrid manager Jose Mourinho insists his side will not alter their tactical approach to deal with Barcelona sensation Lamine Yamal in Sunday's massive Liga fixture. The Portuguese coach dismissed his team's recent thrashings of Sevilla and RB Leipzig, declaring that previous form means nothing during El Clasico.
Colts Make Roster Moves Ahead of Sunday's Matchup
The Indianapolis Colts made roster moves ahead of Sunday's matchup against the Minnesota Vikings.
Apple CarPlay and Android Auto Make Your Phone Hot. Here’s How to Keep It Cool
Powering a car dashboard is more demanding on your handset than you might think. These tips will save battery life and help your phone chill out.
18 Once-Common Things That Quietly Vanished From Our Lives
"I texted one of those numbers on the TV to buy a ringtone back then. Good times. Then smartphones came around, and I've kept my phone on vibrate for over 13 years now."
This fifth-generation family business in rural Pa. is making 4,500 brooms for Salem
On Etsy, the Meckleys have made close to 20,000 sales.
UCLA’s perfect start has one glaring flaw it must fix soon
Bob Chesney has made UCLA the second-half darlings of college football, but the Bruins must address their slow starts if they hope to reach the playoff.
That Ramaswamy ad is repugnant. And it will eventually be seen as a gift to Trump
If Ramaswamy goes down, Trump will spin it that Democrats and the corrupt media misrepresented the ad and lied about Ramaswamy.
UCLA Health expansion raises costs and concerns
UCLA Health has fast expanded its number of hospitals and number of clinics in recent years. Critics say the expansion is raising healthcare costs and question why it hasn’t included lower-income neighborhoods.
UCLA Health expansion raises costs and concerns
UCLA Health has fast expanded its number of hospitals and number of clinics in recent years. Critics say the expansion is raising healthcare costs and question why it hasn’t included lower-income neighborhoods.
Nevada's Republican governor fights to survive Trump undertow
Joe Lombardo is no MAGA warrior, but his Democratic opponent ties him to the president at every opportunity. Lombardo hopes Nevada voters judge him on his performance, not Trump's.
As vote nears, Trump’s AI gamble fuels economic uncertainty
Some of the world’s leading financiers are sounding increasingly alarmed about an AI bubble.
Voters in 2 Democratic strongholds could ban transgender girls from girls school sports
Reliably Democratic Colorado and Washington have ballot measures that would bar transgender girls from some sports competitions
KIII 3 News
KIII 3NEWS is the ABC affiliate in Corpus Christi, Texas, operating to serve, inform and improve communities in the Coastal Bend. The station began broadcasting in South Texas on May 4, 1964. Today, KIII 3NEWS dominates one of the fastest-growing markets in Texas. The station’s service to the community and commitment to local news and weather coverage has consistently made it the Coastal Bend's news leader for decades.
Liverpool will trigger Ronald Araujo clause on one condition
Ronald Araujo’s loan spell at Liverpool could yet become permanent.Spanish outlet Marca reports that the Reds are willing to trigger the centre-back’s £47m purchase option should his current perf...
“We Have No Business up There” – Gattuso Insists Lazio Are Targeting 40 Points
Gennaro Gattuso urges Lazio to keep their feet on the ground and focus on modest objectives despite leading the Serie A table.Lazio Overcome Parma TestThe Biancocelesti raised their tally to 22 from a...
Swapping horses for ninja warriors: The Olympic sport undergoing massive change
Several Olympic sports have evolved over the years to keep up with an ever-changing landscape, but few have been as drastic as the Modern Pentathlon.
Warriors are calling it left knee soreness for Gui …
Warriors are calling it left knee soreness for Gui …
'Supercharging bras': The story behind Victoria's Secret's $6 billion business turnaround
Victoria's Secret is in the midst of a historic comeback, with sales surging and its stock on track to notch its best-ever year. What gives? https://bit.ly/4BhD84S
The boss whose twice-bust business appears to be back despite £3m debts
Andrew Woosnam took millions from his companies before leaving creditors including HMRC out of pocket