SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " challenging " 525 found 🔀 AI-powered Shuffle
'Never complain, never explain': Buckingham Palace broke its own golden rule over Princess Diana claims
Buckingham Palace has taken the unusual step of challenging Earl Spencer's account of King Charles's reaction to Princess Diana's death.
The U.S. Chamber is Working Tirelessly to Defend the Trump Administration’s Deregulatory Initiatives, Preserving Benefits for American Business
The U.S. Chamber of Commerce Litigation Center is fighting on two fronts — defending Trump-era deregulation in court and challenging unlawful Biden-era regulations — to ensure pro-growth policies endure beyond political shifts.
iPhone 18 Pro vs. iPhone Duo Buyer's Guide: Which Should You Choose?
Apple's new iPhone lineup asks buyers a new and challenging question: Is a foldable display worth feature compromises? Alongside the iPhone 18 Pro and iPhone 18 Pro Max, which start at $1,199 and $1,299 respectively, there is now the iPhone Duo, Apple's first foldable iPhone, which starts at $1,999. All three are brand new, all three feature the same A20 Pro chip, and all three sit at the top end of Apple's lineup.
Veterans Put Military Skills to Work in Business: Entrepreneurs Share How Service Helped Shape Careers
Starting a new business can be challenging and intimidating. For military veterans who take the entrepreneurial leap, however, the training and experiences they gained in the service can provide valuable tools for success — along with some challenges of their own. Five local business owners shared their experiences transitioning from military service to entrepreneurship during
Trump is set to campaign in N.C. with his Senate nominee, Michael Whatley
Whatley, who was Trump’s pick for the Senate race, faces a challenging contest against Democratic former Gov. Roy Cooper.
Jaina Lee Ortiz breaks down the ‘weird and wacky’ ‘R.J. Decker’ season 2 premiere
Jaina Lee Ortiz is dropping major teases for ‘R.J. Decker’ season 2, from another love interest challenging her ‘slow burn’ dynamic with Scott Speedman’s R.J. to a shocking reveal around Victor Ochoa’s fate.
Scientists “truly astonished” by discovery that challenges Earth’s origin story
A new study suggests Earth formed almost entirely from material in the inner Solar System, challenging the idea that water-rich material from beyond Jupiter played a major role. If correct, Earth’s water may have been present much closer to the young Sun than scientists previously thought.
A machine learning system that identifies cancer cells based on how they scatter light
Cytology tests are widely used for cancer screening, but diagnosis can be challenging when tumor and non-tumor cells look very similar. Researchers from Japan developed a machine learning system that identifies tumor cells based on their white-light scattering spectra. The approach achieved high diagnostic accuracy for mesothelioma and showed potential for distinguishing several other tumor types, offering a promising approach for enhancing cytological diagnosis.
Warcraft 3 Is 'The Best Storytelling Medium Warcraft Has Had
'An MMO can be challenging in terms of building up and conveying a connection to characters'
One Couple’s Wedding Venue Struggle Exposes Maine’s Hostile Business Climate
Governmental hurdles in Vassalboro are proving just how challenging it can be for aspiring business owners in Maine.
Outcome of employment lawsuit could promote use of skimpy health plans
A long-running lawsuit challenging what it means to be an employee and therefore have access to work-based health plans is being closely watched by health policy analysts.
California, others challenge Trump effort to deny green cards over past use of public aid
California and others filed lawsuits Monday challenging new Trump administration rules for denying green cards to applicants who have relied on public assistance.
Business Leader Briefing with Senator Fischer: What Small Businesses Should Know About the Expanded Paid Leave Tax Credit – September 24 - Small Business & Entrepreneurship Council
11:00 AM ET September 24, 2026 Providing competitive benefits like paid family and medical leave can be challenging for small businesses, but a recently expanded federal tax credit could help make it more affordable. Join Public Private Strategies on September 24 at 11:00 AM ET for a virtual business leader briefing on the newly permanent […]
Working in retail in my 50s despite my college education; challenging
With decades of experience in the social-work field and a college degree, I didn't expect to be working a part-time retail job in my 50s to get by.
‘My invasive thoughts were harrowing’: Alanis Morissette shares candid insight into ‘out of control’ postpartum depression
The singer is very honest about the incredibly challenging experience she had with depression and 'activity' after each of her three children
Phoenix Suns 2026-27 Player Profile: Collin Gillespie
After a record-breaking shooting campaign, the sharpshooting guard aims for stardom by refining his drive-and-kick game while challenging for a spot in Phoenix’s star-studded starting rotation.
The politics and possibilities of ‘AI could kill us all’
I found myself fielding a lot of questions from folks who don’t usually talk much about AI this week. They were mostly along the lines of “do you think AI is going to kill us all?” or “how worried should I be about this human extinction stuff?” Motivating this wave of existential anxiety was the highly dramatic resignation of now-former Anthropic employee Jacob Coxon, who quit his job while publicly sharing his concerns about safety practices at the leading AI companies. More specifically, he declared that almost everyone at OpenAI and Anthropic, the leading AI labs, believes that there’s a decent chance the AI systems they’re producing could “kill us all” by the end of the decade, and the companies aren’t “acting responsibly.” Other AI safety researchers, including those still employed at Anthropic and OpenAI, all confirmed that yes, Coxon is correct, they’re all worried that their company’s products might prove fatal for the entire human race as well. Two more AI employees quit and joined the chorus. Now, the warning shot has been covered everywhere from the Wall Street Journal to Fox News to WIRED to the Guardian. I understand why all this sounds scary, but my response to those who have asked, has generally been: No, you don’t need to worry that AI will kill go rogue and kill us all. But that does not mean we shouldn’t worry, period. Far from it. The companies building AI products are now among the wealthiest and most powerful entities in the world. And they very much are building enormous engines of mass surveillance, extraction, and automation. They can and have allowed their AI systems to carry out felony hacks of other companies, provided the government with autonomously generated kill lists, and sold enterprise technology to firms around the world that is explicitly intended to replace jobs. But “AI” has done these things not because they have all-powerful minds of their own but, ultimately, because people have programmed, calibrated, and directed them to. In other words, it’s not AI we need to worry the most about. It’s the people and corporations working to profit from and gain power by deploying it. The technology is sophisticated, sure, and, especially in cybersecurity contexts, potentially disruptive to plenty of existing systems. But if we want to stop this predatory, profiteering, and extractive form of AI—and it’s worth noting that at this point, most people do—we absolutely can. A quick note/plea: I can only do all of this with the support of readers like you, so if you find value in independent, critical tech journalism and analysis, please consider becoming a paid subscriber. I want to keep as much of this un-paywalled as absolutely possible, and I need your support to do so. Many thanks to all who continue to chip in, it’s very much appreciated. Onward. Subscribe First, some context: AI industry folks like Coxon have been discussing the prospect that AI will destroy humanity for years. Even before the beginning of the AI boom, many working in the industry, from the executive staff to the rank and file researchers, have obsessed over ‘x-risk’, or the possibility that AI will become sentient or semi-sentient and move one way or another to exterminate humanity. This is ostensibly why Elon Musk bankrolled OpenAI in the first place, and is the grounds for his lawsuit alleging OpenAI betrayed its charter by abandoning its nonprofit status to become a commercial enterprise. Many AI engineers and startup founders have calculated their own personal p(doom), or the probability that the tech product they are working on will initiate an actual humanity-extinguishing apocalypse. 10-25% p(doom)s are pretty common. (I wrote about a long weekend I spent among these folks at one of their top conferences here, to give you an idea of their ideas and belief systems.) Sam Altman himself drove the narrative of the imminent rise of a super-powerful AI, or artificial general intelligence, to prominence by declaring that the technology he was building posed an existential risk to humanity. This idea is in other words baked into the DNA of modern AI companies and into the products they engineer. It’s also why the industry is routinely accused, by myself and others, of “doom marketing,” ie, using such proclamations and framings to impart the sheer power of the technology behind your product onto investors, partners, consumers, and the state. Some ambient understanding of this tendency may have helped prevent the press from repeating the claim every time one of the x-risk folks made it over the years, including when they quit their jobs at AI companies while doing so. Yet Coxon’s AI x-risk alarm has broken containment, as they say, and has exposed the idea to the mainstream media once again. This has happened, I think, for a number of reasons. First, when AI CEOs were going around saying AI might kill everyone in 2023, their companies were well-capitalized, but not nearly to the extent they are today. They were more easily dismissed as eccentric geeks of the sort that Silicon Valley is supposed to produce. Now, not only do their products have much greater market saturation, but people are more aware of a) the often unethical ways the executives and companies comport themselves b) the other adverse impacts of AI that have already arrived, and c) the physical cost of building these systems, particularly when it comes to data centers. Finally, toss in the constant stream of headlines in 2026 about AI models going rogue or potentially upending the world’s infrastructure. [ ](https://www.bloodinthemachine.com/p/with-the-backlash-to-data-centers) [ With the backlash to data centers, Flock and AI glasses, a mass opposition to big tech is underway. Silicon Valley is in denial. ](https://www.bloodinthemachine.com/p/with-the-backlash-to-data-centers) Brian Merchant · Aug 27 [ Read full story ](https://www.bloodinthemachine.com/p/with-the-backlash-to-data-centers) As a result, general sentiment was already overwhelmingly skeptical of AI and its overlords, so the table was pretty well set for someone to come along and say ‘just a reminder, the companies that are building the product that promises to take your job and leave a data center in your neighborhood also think that it might exterminate the human race’ and get a strong reaction from the media and the public. The question is: Should we understand this stuff as hype, strategically fanned to feed already swelling valuations? Is it doom marketing? Genuine cause for alarm that the infrastructure that undergirds modern life is facing a novel threat vector? Or reason to be sincerely worried that AI companies are amassing too much power, and that their products are genuinely dangerous? The answer, I’m afraid, is “yes.” Let me try to untangle all of this a bit, because arguments over how to navigate this moment are extremely heated right now, as they are essentially arguments over how to approach the politics of AI at a moment where there may be a unique opening for action. Those sympathetic to AI alignment concerns and x risk arguments—which increasingly includes a faction on the left who want to shut down AI over safety concerns—argue that people who dismiss AI as all hype have their heads in the sand. Meanwhile, critics of the x-risk narrative—which I might note includes a cadre of investors and tech folks on the right, too—argue that it is hype and can be used to further inflate valuations or for pursuing regulatory capture. The challenge is that many feel that dismissing AI as just hype or purely marketing also diminishes the urgency of taking on the AI industry as the novel and threat to labor, civil society, and the public sphere it is; others that by accepting the industry’s own terms, we imbue it with undue power and enable it. But let’s be clear: Declarations that AI is so powerful it might end the world are a kind of marketing, and anyone who says otherwise is just as off base as those who say that’s all that it is. If you don’t think that these sub-trillion dollar companies have higher-ups who noticed that when their founders talked about super-powerful dangerous AI they got spikes in media interest and phone calls from investors, or that those founders didn’t notice that themselves, and lean into certain narratives to advantage their products, then I don’t know what to tell you. Not all marketing is a Pepsi ad campaign with a celebrity spokesperson. Yet confronting the AI industry should certainly be considered an urgent project. Do I share the x-riskers’ fear that out-of-control, super-intelligent AI agents might end the world? I do not. I’ve read a good deal of AI extinction literature over the last couple of years and I have not come across a credible, step-by-step documentation of how exactly AI might move from self-recursively improving AI to killing every single human on the planet. Most of what I’ve read seems predicated on a sort of reverse Ian Malcolmian logic: Eventually, it becomes smart enough and AI, uh, finds a way (to exterminate humanity). Are the AI companies also overstating and dramatizing what their products can do? Yes, pretty much all the time. They’re in a knife fight for market share and are trying to win customers and government contracts before their investors come knocking. And yet. They have concentrated enormous amounts of compute, have extensive data collection and surveillance capacities, have inserted themselves into the state in numerous capacities, including military kill chains, and they are being run by egomaniacal billionaires who are rushing to monopolize an entire new market. The way I think about their most recent frightening-seeming exploits is not as a “swarm of rogue AI agents building a new civilization” or whatever, but as corporations with a hitherto-unimaginable amount of compute at their disposal recklessly experimenting with automation programs, completely unafraid of any repercussions because we have been unwilling or unable to impose any on them. So I think we should welcome any newfound imperative to hold them accountable. I also think that ultimately, the AI critics, Pause AI folks, leftists, doomers, effective altruists, and, honestly, most of the public, want a lot of the same things: legitimate checks and limits on AI companies’ power, actual transparency into what the companies are doing, and for more of AI to be under public control. (Ultimately, a lot of what animates the x-risk fears are rooted in just that: a fear of losing control.) How we move towards all this, exactly, is the question of the day, and while there’s much to be argued over in terms of building a viable political platform to challenge the AI industry’s power, I do want to cast a vote against one particular approach. Not to pick on Chris here, as there are a lot of folks out there proposing stuff like this, and the policy ideas actually stem from AI safety groups. But not only would this be challenging to land politically (I can already hear the ‘China will beat us to AGI’ calls) and all but unworkable in practice, this approach is a) far too limiting, b) fails to address the current harms caused by AI and c) would likely only wind up serving Anthropic and OpenAI; it’s what regulatory capture looks like in action. Full model transparency is the floor for what should be on offer here. If these companies believe their products will kill us, the very least we deserve is to know how. It’s in the public interest. I would also argue we might get a lot of the way to stopping any currently envisioned robot apocalypse simply by forcing AI companies to assume liability, and to submit to the full brunt of the law. If Sam Altman were liable to be charged with a felony for approving the hack on Hugging Face1, if Google was forced to pay defamation fines each time it published a false and injurious AI Overviews, these companies might suddenly find cause to restrain their models’ output, and we might hear less about rogue AI. We would need to introduce new frameworks and available tools for tracking automated lawbreaking, to be sure, but I’d wager that little would frighten the AI companies more than actually being held accountable for what their products enable. To that end, Illinois has passed an AI liability law, which the industry fought tooth and nail, and Florida is considering one. The next steps would be towards moving AI under public control; again, it’s only reasonable, since everyone, not just AI insiders, should get a say over how a technology whose developers say might kill us is developed and deployed. Dismantling the whole industrial project as currently structured should be on the table, too, pending democratic input. But that’s for another post. For now, suffice to say that while I won’t be losing any sleep about an AI-enabled extinction event, Mr. Coxon and co. have given us an opportunity to underscore the urgency of the clear and present damage AI companies are doing, the extreme power they wield and the extent to which they hold themselves unaccountable, and the abundance of political capital there is out there for taking them on. Subscribe 1 Purely speculative! I do not know if he did or not.
Moderna, 10x Genomics, Oscar Health, and Novavax Shares Are Soaring, What You Need To Know
A number of stocks jumped in the morning session after Morningstar reported that challenging macroeconomic conditions across broader equity markets drove a rotation into healthcare, lifting the sector index by approximately 7% quarter-to-date to reach a 5% valuation premium.
Moderna, 10x Genomics, Oscar Health, and Novavax Shares Are Soaring, What You Need To Know
What Happened? A number of stocks jumped in the morning session after Morningstar reported that challenging macroeconomic conditions across broader equity ma...
Hughes optimistic after challenging transfer window
Portsmouth sporting director Richard Hughes is "optimistic" about the squad he has helped to build following the completion of the transfer window.
Colorado doctors, dentists challenge state law on gender‑transition services in new federal lawsuit
A group of Christian doctors and dentists has filed a federal lawsuit challenging a Colorado law they say requires them to provide gender‑transition services that conflict with their religious and ethical beliefs. The lawsuit, filed by the Christian Medical and Dental Associations and Button Family Practice of Cañon City, alleges that certain portions of Colorado’s […]
Public Health Leaders and 161 Scholars File Amicus Brief Challenging CMS Medicaid Work Requirement Rule
Amici argue new federal rule could cause millions of people with serious health conditions to lose Medicaid coverage
Optum Health CEO pulls back curtain on turnaround
As UnitedHealth Group continues to chart its turnaround from a challenging 2025, the company's top brass is pulling back the curtain on those efforts at its healthcare services unit, Optum Health.< | As UnitedHealth Group continues to chart a turnaround from a challenging 2025, the company's top brass is pulling back the curtain on those efforts at its healthcare services unit, Optum Health.
Burgess Article on Joints Reflects Growing Recognition of Design
A journal committed to scientific materialism publishes an article explicitly challenging evolution and promoting design.
Titans Veteran Sends Meaningful Message to Teammates
Solomon Thomas rejects the rebuild narrative, challenging a revamped roster to embrace a win-now mentality and transform Tennessee’s culture after years of double-digit losses and coaching turnover.
The Lucas Museum's approach to curation courts controversy
The Lucas Museum of Narrative Art is challenging art-world hierarchies by placing commercial art, comics and pop culture works in conversation with pieces by Frida Kahlo, Mary Cassatt, Pablo Picasso, Vincent van Gogh and more.
‘Last Seen’ review: Apple TV mystery thriller gets lost down under
For a show that began as potentially darkly poetic or challenging, "Last Seen" (which premieres Wednesday on Apple TV) plays it far too safe, writes our reviewer.
Annapolis' Storm Brothers Ice Cream expands menu as City Dock construction hurts business
Owner Sveinn Storm said high rents and seasonal crowds have always made running a business downtown challenging, but the City Dock construction has added to the strain.
Can William Lawrence, a Progressive, Flip a Key Michigan House Seat?
William Lawrence, a progressive challenging a first-term Republican, is trying to rewrite the playbook for Democrats running in swing districts.
Justin Jefferson Gets Blunt Prediction Before Vikings-Packers Game
The 2025 NFL season was a challenging one for Minnesota Vikings wideout Justin Jefferson. Due to the quarterback play, Jefferson barely recorded over 1,000 receiving yards. The Vikings star recorded an 80.5 PFF grade along with 84 receptions on 140 targets, 1048 receiving yards, and one touchdown.Moreover, Jefferson registered 12.5 yards per reception, 5.2 yards […] The post Justin Jefferson Gets Blunt Prediction Before Vikings-Packers Game appeared first on HEAVY.
Political notes: Ivey co-chairs CBCF, Ausby to Appellate Court, another Haley honored
Rep. Glenn Ivey (D-4th) co-chairs the annual conference of the Congressional Black Caucus Foundation at a challenging time for the caucus, Simon Haley is honored at UMES and Kendra Young Ausby is elevated to an Appellate Court judgeship, in political notes.
I'm applying to entry-level jobs at 56 and can't get an interview
Jennifer Mannix, 56, changed careers after 30 years. Getting an entry-level interview has been challenging, and she thinks her age plays a role.
Prof Elizabeth Streicher unravels the science behind drug-resistant TB
Prof Elizabeth Streicher of the Division of Molecular Biology and Human Genetics delivered her inaugural lecture on Tuesday 1 September 2026. Her research focuses on the transmission and spread of Tuberculosis (TB). Knowing where TB transmission is happening can help to stop it from spreading. Prof Elizabeth Streicher of the Division of Molecular Biology and Human Genetics in the Faculty of Medicine and Health Sciences delivered her inaugural lecture on Tuesday 1 September 2026. The title of her lecture was Decoding tuberculosis: the evolution of technology, epidemiology and the Mycobacterium tuberculosis genome. Streicher explained to Corporate Communication and Marketing how molecular epidemiology (using genetic information to track how and why diseases spread through populations) has improved our understanding of where drug-resistant TB comes from, how it spreads and how drug resistance evolves within and between populations. Tell us more about your research and why you became interested in this specific field. Overall, our research group studies the genome (complete set of DNA instructions found in a cell) of Mycobacterium tuberculosis, the bacteria that cause tuberculosis (TB) disease. Various regions of the genome are interrogated to study different aspects of the disease. My main focus has been on the epidemiology of tuberculosis – how the bacteria’s genome changes over time and what this tells us about the transmission and spread of the disease. How would you describe the relevance of your work? If we understand how the bacteria that cause TB change and spread, it can assist in combating TB globally. How has molecular epidemiology helped improve our understanding of drug-resistant TB? Molecular epidemiology was very important in drug-resistant TB as it was originally believed that bacteria that become resistant to antibiotics would be less fit and not be able to transmit. But it was shown that they can transmit, and therefore have to be monitored to identify hotspots of transmission and outbreaks, etc. Can you tell us briefly about the spoligotyping technique and its advantages for studying drug-resistant TB? Spoligotyping (a molecular technique used to identify and track specific strains of TB bacteria) does not detect drug resistance, but since the technique is relatively quick to do, it can be very useful in real-time situations, e.g. to monitor outbreaks of drug resistance. Why are interrupting transmission chains and identifying genomic hotspots important for controlling the spread of TB? Knowing where TB transmission is happening can assist in allocating resources to those areas to stop future transmission and spread of TB. Higher education can be challenging. What keeps you motivated when things get tough? Students – how they are so passionate and dedicated to learning and contributing to research and society as a whole. What aspects of your work do you enjoy the most? Again, the students and colleagues! But also the fact that it is continuously changing and thereby we are learning and expanding our knowledge. In the end, I know that we contribute to a better society in our small way. Tell us something exciting about yourself that people would not expect. Even though I love hiking (day and multi-day hikes) and being outside, I really do not like camping! How do you spend your free time? I love hiking (wellbeing in nature) and like to watch most sports. ©Higher Education Media Services. Subscribe
Russell accepts title gap to Antonelli is difficult to overcome
George Russell admitted it is going to be “exceptionally challenging” to prevent Kimi Antonelli from beating him to the world championship after his rival produced a stunning fightback drive from 19th to win the Italian Grand Prix. Antonelli became the first Italian to triumph at Monza’s Temple of Speed since Ludovico Scarfiotti stormed to victory in 1966.
Patriots’ Josh McDaniels Has Strong Words for Seahawks’ Defense
The last defense the New England Patriots offensive coordinator, Josh McDaniels, faced was the Seattle Seahawks, with head coach Mike Macdonald running the show in Super Bowl LX. Now, the first defense McDaniels will see at the start of the 2026 season is the Seahawks.In the Super Bowl LX win, the Seahawks made life challenging […] The post Patriots’ Josh McDaniels Has Strong Words for Seahawks’ Defense appeared first on HEAVY.
When Distress Has No Name: Re-thinking Mental-Health in Pakistan
Sangji uses one woman's story to show that emotional distress in Pakistan is shaped by patriarchy, poverty, trauma, and history, challenging individualised psychiatric diagnoses while advocating culturally grounded, systemic understandings of mental health.
Lulli on Gasperini: “He gives me so much confidence.”
Emanuele Lulli spoke to Sky Sport before the match against Atalanta.“It’s definitely more challenging than the previous two, it tests our maturity, but we know we need to approach it with greater ...
Vikings rookie defender challenging veteran for key role
The Vikings may have a surprise Day 3 contributor who can step into the defensive backfield immediately.
Video: The C.D.C. Is Waging a Political Fight Over Measles Deaths
After Pennsylvania reported two measles deaths, the C.D.C. took the highly unusual step of challenging the state. Our reporter Apoorva Mandavilli explains how this tension between the Trump administration and states over health issues is creating confusion for Americans.
Manny Rutinel resigns from Colorado legislature to focus on congressional race
The Democrat running for a key congressional race — whose outcome could decide the balance of power in the U.S. House — on Friday resigned from the Colorado legislature. State Rep. Manny Rutinel is turning his attention to his campaign in Colorado’s 8th Congressional District, where he is challenging Republican U.S. Rep. Gabe Evans. The […]
Democrat Manny Rutinel resigns from state House to focus on competitive race in Colorado’s 8th Congressional District
Democratic Rep. Manny Rutinel resigned from the state legislature Friday to devote his full attention to his campaign in Colorado’s 8th Congressional District, where he is challenging Republican U.S. Rep. Gabe Evans. The open seat in House District 32 will be filled by a vacancy committee. The Adams County Democratic Party has not responded to […]
Trump’s tariff war with Canada adds uncertainty for Alaska businesses already grappling with higher prices
Trump’s trade fight with Canada could be especially challenging in Alaska, with the two sides sharing 1,500 border miles and positive economic ties, said the head of the Alaska International Business Center.
Michigan House candidate Katrina Manetta talks about healthcare access and affordability
Manetta is challenging Republican state Rep. Ron Robinson in the 58th District in the Nov. 3 election.
Feld Entertainment CEO on prioritizing innovation, challenging assumptions
To foster innovation, Feld Entertainment, under CEO Juliette Feld Grossman, prioritizes creating an environment that allows people to take risks and challenge assumptions.
Feld Entertainment CEO on prioritizing innovation, challenging assumptions
To foster innovation, Feld Entertainment, under CEO Juliette Feld Grossman, prioritizes creating an environment that allows people to take risks and challenge assumptions.
Federal judge dismisses DOJ lawsuit challenging California policy allowing biological males in girls’ sports
A federal judge dismissed the Department of Justice lawsuit against California over transgender athletes competing in girls' sports on procedural grounds.
Sony and Microsoft say they’re not obligated to pass U.S. tariff refunds to consumers, echoing Nintendo
Back in July, Sony executives told investors that the company expected to receive $508 million in refunds from the U.S. government, after tariffs that the PlayStation-maker paid were ruled mostly in 2025 were found to be illegal. “Most” of the refund would by recouped by Sony’s gaming division, its chief financial officer said. This week, Sony’s lawyers are arguing that the company is not legally obligated to pass those proceeds on to consumers who paid for recently price-hiked PlayStation consoles. That’s in the face of a lawsuit from gamers calling on them to do exactly that. “Paying fair market price for voluntarily purchased consumer goods is not a legally cognizable injury in fact,” the lawyers wrote in a legal motion filed on Monday, as they asked a judge in California’s Northern District to dismiss a potential class action lawsuit over the tariff refunds. Microsoft made a similar argument two weeks ahead of Sony’s lawyers, in a similar lawsuit brought by a gamer in federal court in Washington State. As Microsoft’s legal team put it on August 21, in their request for a dismissal of that lawsuit: “There is nothing unjust about Plaintiff purchasing an Xbox at an advertised price and getting exactly what he paid for—regardless of whatever theory he devised months later about Microsoft’s cost structure.” Both legal fights are set to go on for some time. How things got to this point U.S. tariffs impacting a wide range of imported goods, including game consoles, had kicked off in early 2025. In May 2025, Microsoft raised the price of its Xbox consoles, citing “market conditions and the rising cost of development.” They raised them again that September. In August of that year, Sony raised the price of PlayStation 5 consoles, citing “a challenging economic environment.” Sony later told investors that its tariff fees for the fall quarter were nearly $200 million. in February of this year, the U.S. Supreme Court ruled the 2025 tariffs illegal, prompting impacted companies to begin to request refunds. In turn, consumers began suing the likes of Sony and Microsoft to get what they said was their share. The gamers in the Microsoft and Sony lawsuits argue that the 2025 price hikes of PlayStation and Xbox consoles, which added $50 or more to their sticker price, were due to illegal tariffs and should now be returned to consumers. The Sony suit started in May, when a group of gamers sued in federal court in California, saying Sony Interactive Entertainment (PlayStation) would be unjustly enriching itself if it did not pass tariff refunds to its PS5 buyers. “Sony is poised to be paid twice for the same unlawful tariff burden: once by its customers (through elevated prices) and once by the U.S. government (through tariff refunds),” the gamers’ lawyers wrote at the time. They called for Sony to partially reimburse anyone who bought a PlayStation in the U.S. since August 1, 2025. The Microsoft suit, filed by gamer Trevor Hastings against the Xbox giant in July, made similar claims. The console makers push back In late July, Nintendo’s lawyers, facing a similar suit accusing them of double-dipping on tariffs and refunds, replied with arguments that previewed Microsoft’s and Sony’s: “Nintendo or one of its retailers set a price for each product, and consumers decided whether that price was worth paying,” they wrote. Sony has buttressed that Nintendo-style argument this week by saying that the gamers have failed to prove that tariffs were the reason for its August 2025 PS5 price hike. They call thatclaim “speculative and illogical.” Other factors, including “inflation, currency fluctuations, component costs, logistics, competitive dynamics, or demand,” could have played a role. (No, the Sony lawyers do not break down the costs and factors that officially triggered the price increases). Microsoft has also argued that there’s no proof in these lawsuits that tariffs drove all or some of the price increase, as it seeks to dismiss the tariff refund suit it’s facing: “Plaintiff provides no specific allegations that would establish any pricing differential attributable to tariffs or suggest any possibility that Microsoft applied then or could recreate now any dollar-for-dollar calculation of tariff-related pricing—any more than it could any other market factor that affects pricing.” To further skewer the gamer side’s argument in its case, Sony’s lawyers have pointed to what might be a surprising defense: yet another PlayStation 5 price hike from this past spring, after the tariffs were ruled illegal. “If the original price increase were attributable to tariffs, SIE [Sony Interactive Entertainment, aka PlayStation] would have had no reason to raise prices again after the Supreme Court invalidated the IEEPA tariffs.” … “If tariffs were the cause of the price increases, one would expect SIE to lower prices once the tariffs were eliminated—not raise them again. Instead, the timeline confirms that the pricing of PlayStation consoles includes a diverse and dynamic set of input costs.” Judges have not yet ruled on the arguments made by Sony, Microsoft or Nintendo. Last week, Panic, the company behind the small, yellow Playdate handheld said it would be passing its tariff refunds on to consumers. It is the only gaming hardware maker to have made such a pledge. Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Item 2: A reporter’s second Second Life Wagner James Au, who from 2003-2006 was paid by San Francisco-based tech company Linden Lab to be a full-time journalist embedded in their virtual world Second Life, is returning to the company. This time, he’ll be an editorial advisor and business development specialist, he tells Game File. The new role will involve trying to share the stories of people inhabiting Second Life’s ongoing online world with reporters and by extension the public. Au plans to continue to also chronicle some of that through his long-running blog New World Notes. I’ve known Au since the mid-2000s and featured him in a 2007 article for the Columbia Journalism Review about reporters like him opening up virtual news outlets within Second Life. As I wrote at the time: On April 22, 2003, writing as Hamlet Linden for the New World Notes blog on Second Life’s Web site, Au introduced himself. “For the next few months, Linden Lab has invited me to set aside my journalist cap, and instead, don the digital beanie of their in-house virtual correspondent.” He wasn’t paid to keep it positive. He wrote about builders and eccentrics, but then in August of that year, he reported on a tax revolt against Linden Lab (a complaint about the fees it charges users who build stuff) led by a resident whose avatar was a big cat. Second Life has always been less of a video game and more of a virtual world where people can live, hang out, make art, sell virtual items and flirt. Back in 2007, Au described touring it as “sort of like underwater lucid dreaming.” For the past two decades, Au has maintained New World Notes as an independent publication. But he said he’s been drawn back to Second Life and Linden Lab as a place to directly work. The virtual world has around 650,000 monthly active users, he said, “which is actually about what it was during the hype wave.” Au says he’s still finding rich stories in Second Life, the kind that keep him interested 20 years into the beat: “Over the last few months for instance, I wrote about an SL creator in Venezuela whose apartment was destroyed by the earthquakes, so the global SL community rallied to get him back on his feet,” he told me. “Then there’s the woman from a Middle Eastern country who explored her lesbian sexuality in SL, then earned enough from her virtual jewelry to escape her abusive family situation and country.” Au wants to beckon more reporters to give Second Life another look. He argues that it is often ahead of internet trends, noting, for example, an early backlash in the community against AI-made art. Now the platform is drawing curiosity from more of the user-generated content community who’ve grown up with the likes of Roblox, according to Au. “Second Life was too early during its hype wave in 2005-2010, but it now feels right for a new wave of interest,” he told me.
Vermont joins 22-state lawsuit challenging federal rule on transgender youth healthcare
Vermont is challenging a federal rule on transgender youth healthcare.
Dragons Dogma 2 Devs Says RPG Players Want Opposite Things
Balancing player expectations between the two regions proved challenging
State employees may see health insurance premium rise amid 'challenging' budget forecast
The two boards overseeing health insurance for state and public education employees Tuesday approved plans to ask the Legislature for more funding amid growing healthcare costs and expected difficulties with the state budget.
What Box Office Bomb Crushed Obsession on Streaming?
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) Before we get into this week’s issue, let me ask you for some suggestions. At the risk of coining too many names for too many things (hence my dictionary of terms...), I need a name for straight-to-streaming films that are too expensive to justify a straight-to-streaming release, but not big enough to justify a theatrical release. Like some of the films I highlighted in last week’s tally of the biggest film flops of 2026 so far: Hulu’s Mike & Nick & Nick & Alice, Pizza Movie or Never Change! They don’t feel like “made for TV movies” (think Hallmark and Lifetime movies, cheap Netflix romcoms, or Disney Channel Original movies, for example) but they don’t feel big enough for the big screen. They’re not “cinematic” enough, so to speak. As I wrote... “I still need a name for this middle zone of film that’s too expensive to go straight-to-streaming but too small to justify a theatrical release (with all the PR, distribution, marketing and whatnot costs that go along with it), the Goldilocks zone of streaming film death.” Friend of the newsletter Brandon Katz has suggested the “Bermuda Budget Triangle”, “The Platform Gap” and “The Distribution Deadzone”. I love that first one. I’d offer up the much wordier “The Streaming Budget Dead Zone” or “the Goldilocks Zone of streaming film death” but that last one isn’t accurate since, unlike Goldilocks’ porridge, these films are the opposite of “just right”. That’s the problem! Anyway, if you have any suggestions, let me know! On to today’s Streaming Ratings Report. As you can tell by today’s headline, things are going to be spicy! I’m looking at a box office bomb that did really, really well on streaming, somewhat challenging a few different narratives. And another Netflix series declined in its second season. All that, plus Wicked: For Good switching streamers, The Hawk continuing its strong run, _The Bear’_s finale season finally dropping off the charts, the WNBA posting a big viewership number, “shallow libraries”, a sitcom spinoff failing to launch, more big budget IP flopping on Paramount+, all the flops, bombs and misses, and a whole lot more. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of July 20th to July 26th, 2026. You can find a link to my terminology here.) Subscribe Film - The Latest Theatrical Success Story on Streaming In the latest edition of “Flops, Bombs and Misses of the First Half of 2026”, I made a crucial change: I started including theatrical films with the streaming misses. The streamers have collectively—including Netflix, but not to as big of an extent—stopped making a lot of straight-to-streaming films, and the ones they do make aren’t as expensive as in the heyday of the streaming bubble. After the following two films bombed in theaters, you’d guess that they’ll be included in my next collection of flops, bombs and misses six months from now: Masters of the Universe on Prime Video (only $64 million domestic box office) Mortal Kombat II on HBO Max ($79 million domestic) But you’d be wrong! Masters of the Universe, a reboot of the He-Man franchise, a toy from the 1980s, came to streaming on 22-July and did great! This long-gestating project—it’s been at every studio for years, and came close to getting a greenlight at Netflix—then finally came to theaters in June, and showed up on streaming less than two months later. (I don’t love this short theatrical window.) It surprisingly grabbed nearly 20 million hours on its debut: That means, wait for it, Masters of the Universe is currently the eighth biggest film on streaming through two weeks. My rough bar for “hit” is shows or films in the top 15%. Ergo…Masters of the Universe is a legit, streaming hit! (One quick caveat: if it falls out of the top ten next week, it will move to 13th overall, just on the edge of the top 15.) Of course, that’s the data for just 2026. Here’s how it stacks up to Prime Video’s theatrical films: That drop into its second week is typical for Amazon films, but also a worrying sign. I have a feeling interest in this film is front-loaded and we’ll see it drop off after this. As for Mortal Kombat II, in this case, the viewership numbers roughly match the theatrical outing, with only 4.1 million hours in its first week. Here’s how it stacks up to other HBO Max films: The best defense of this number is that, as a relatively violent rated-R film, Mortal Kombat II never had a good chance at breaking out. So now it’s time for a little big of “Entertainment Nuance Guy”: First, yeah, my headline is obviously facetious, since Masters of the Universe besting Obsession says more about horror as a genre than it does that film. Second, I read and listened to quite a few “nobody wanted this IP” takes about Masters of the Universe, and that’s not really true. At least enough people wanted it to power a 20 million+ hour debut! Third, both this film and Mortal Kombat II were considered “average” by viewers, but not great films, with a 6.4 and 6.3 respectively on IMDb. That’s just shy of the level needed to be a word-of-mouth hit. Fourth, in the olden days, strong word of mouth could transform a box office miss into a cable/DVD hit, like Austin Powers or The Shawshank Redemption. We haven’t seen a lot of examples of that on streaming, though. And there are far fewer ways to monetize the post-theatrical life of a film these days. Fifth, Prime Video has shown an ability to push their own titles well, likely because they control the Amazon Fire TV ecosystem. Add it all up, and here’s my nuanced take on Masters of the Universe: it was a box office bomb, but, shockingly, a streaming hit. Unfortunately, while being a theatrical hit saves your film financially, being a streaming hit does not. Both Masters of the Universe and Mortal Kombat II had big budgets and needed to make more money in theaters to justify them. So…Straight-to-Streaming or Theaters? We’ve hit a really fun point in the streaming calendar, since the films that came out in theaters in April, May, and June are now arriving on streaming. So the “Do theatrical releases help streaming performances?” question is gonna get a fresh round of updates nearly every week. No single week will answer the question, but we may get some insights. For example, so far in 2026, it looks like theatrical films are lasting longer on the weekly Nielsen film charts. Here’s a list of films that have made the charts in their fourth or fifth week of release, separated by “for kids” and “general entertainment”: It certainly seems like theatrical films are lasting just a pinch longer on the charts, with Project Hail Mary being the current five-week champion. One Battle After Another did well for HBO Max too, and even The Sheep Detectives made it four weeks. The only exception to this trend? Obsession, which only lasted two weeks on the charts. You might tempted to overreact to this news. Don’t. Obsession is a huge horror hit, but horror just doesn’t do as well on streaming. By the way, here’s the Google Trends for various theatrical and stremaing films: Plus, when it comes to Netflix in four months, Obsession may have another big boost. Quick Notes on Film Note that when I write, “the streamers have pulled back on straight-to-streaming films” that doesn’t mean “abandoned” because Netflix is gonna Netflix. On 24-July, they released 72 Hours, a Kevin Hart comedy. Along with Eddie Murphy, Mark Wahlberg, John Cena and Adam Sandler, Kevin Hart is a streaming film star now. Did this latest one work? Not really. It only garnered two weeks of 13.2 and 12.2 million hours on its debut, well below the 20-million-hour hit threshold. It also was poorly received critically—a 44 on Metacritic—and by customers—a 5.4 on IMDb on 21K IMDb reviews. We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… The latest Netflix true crime doc to pop on the charts… How The Bear finished its run… Netflix’s latest Western to return to streaming… What Paramount+ animated film flopped… And what sitcom also missed… All the flops, bombs and misses… And a whole lot more… ...please subscribe! We can only keep doing this great work with your support. Coming Soon! I’m behind by a week, so we’ve got two issues coming your way this week, including one in a couple of days or so, then we’ll be all caught up**.** Next issue, inspired by The Super Mario Galaxy Movie coming to Peacock, I’m going to take a look at the workhouse of streaming TV: kids films. Plus The Devil Wears Prada 2 continues theatrical films’ big run on streaming. All that, plus another surprise hit on Hulu, Lioness on CBS, and a whole lot more. Long term, LeBron James is filming his own “Last Dance”-style docu-series, surprising no one. But as I’ve been writing about a lot this summer, this genre is really overrated, so whoever ends up buying it (reportedly ESPN) really shouldn’t pay too much for it.
Florida Politics: Hope Florida, Nixon-Moody debate?
Florida Governor Ron DeSantis is set to host a forum with several huge names in the Florida Republican Party, such as Attorney General James Uthmeier and GOP Gubernatorial Candidate Byron Donalds. Meanwhile, Angie Nixon is throwing her hat into the ring, challenging U.S. Senator Ashley Moody to a public debate ahead of the general election. POLITICO Reporter and Florida Playbook author Kimberly Leonard joined FOX 35's Garrett Wymer live over Zoom to discuss what's new in Florida politics.
Night owls experience more mental health issues than early birds and take longer to recover from work
Balancing work and personal life is more challenging for evening types, or "night owls," than for morning types, or "early birds." Evening types have a harder time recovering from work and are more likely ...
Onimusha: Way of the Sword Review: Excellent Action With Some
Onimusha: Way of the Sword (PC) Review – 8/10: Onimusha: Way of the Sword is a challenging and complex action game, and a great start for this series return to
Boston Mayor Wu-aligned Super PAC spent $84K on challengers to senators she opposes
A Super PAC with ties to Wu has spent $84K+ supporting candidates challenging Nick Collins and William Brownsberger, two state senators she’s trying to knock off in Tuesday’s primary election.
This Appalachian memoir author is running as a Democratic contrast to JD Vance
Beth Macy is challenging Rep. Ben Cline in a bright-red Virginia district, hoping her own story and the stories she told about the region will win back rural and working-class White voters.
For The First Time In 25+ Years, GTA 6 Will Make Stealing Cars Hard
Committing grand theft auto in Grand Theft Auto 6 will be much more challenging and rewarding
GTA 6's driving and car-jacking will be "more challenging", Rockstar says, amid a seemingly big push for realism
Rockstar has apparently revamped the series' pick-up-and-play systems for something much more involved - but will it get in the way of the fun?
Senate hopeful’s ex-staffer shared KKK and Nazi imagery, adding to concerns about his associates
Rep. Mike Collins (R-Georgia) is challenging Sen. Jon Ossoff. The former staffer posted a swastika and shared an image of himself in what appear to be KKK robes.
Dick’s Sporting Goods’ Stock Sinks 16% Toward Worst Day In 3 Years—Here’s Why
The sports retailer cut its profit outlook amid a “challenging” market.
Although research on animal production and climate is growing, bringing science to the field remains challenging
A research group from the University of São Paulo analyzed over 1,600 articles and found that research increased by 9.5% annually between 1974 and 2025. The authors advocate for regionalized solutions and public policies to bridge the gap between evidence and implementation.
The science behind later school start times
As Pennsylvania districts consider later bells, Penn Medicine sleep and neuroscience experts explain why adolescent biology can make early school start times especially challenging.
Insider Provides the Latest on Alex DeBrincat’s Future With Detroit
This summer has been more challenging than expected for the Detroit Red Wings. Perhaps, this development should not be a surprise given the way their 2025-2026 campaign concluded. The team missed out on the postseason after holding a playoff position in the standings for every month until the last in April. This disappointing finish to […] The post Insider Provides the Latest on Alex DeBrincat’s Future With Detroit appeared first on HEAVY.
The Herd Builds Community and Connections for Business Grad Students
Starting a graduate business program at Cal State Fullerton’s College of Business and Economics can be both exciting and challenging. For students balancing coursework with careers, family responsibilities and other commitments, finding a community can make the transition to graduate school easier and more rewarding. At Cal State Fullerton, The Herd is working to create that community. […]
NYC business group sues over Mamdani’s city-owned supermarkets
Multicultural Business Coalition Chairman Frank Garcia discusses his group’s lawsuit challenging Zohran Mamdani’s NYC-owned supermarket proposal on ‘Varney & Co.’
Big Apple targeted in lawsuit over Mamdani's government grocery store plans
New York City is facing a lawsuit challenging Mayor Zohran Mamdani's plan to open multiple government-tied grocery stores that offer discounted items.
As Democrats Struggle in Some Western States, Independents See an Opening
From South Dakota to Alaska, independents are challenging incumbent Republicans and eschewing a Democratic label that Western voters find toxic.
What Is Chuwi, The Laptop Brand Challenging Apple?
The Chuwi brand views itself as a challenger to Apple in low-end laptops, but concerns about its processors and new competitors could affect its market.
I created a viral AI watermark remover after Anthropic's announcement
A tech entrepreneur developed an open-source project to remove AI watermarks, challenging Anthropic's watermark plan.
Triad Business Expo brings local business owners together to network, share ideas
Local business owners gathered at the Triad Business Expo in Winston-Salem to connect, learn and explore opportunities for growth amid a challenging yet innovative market.
A strange new quantum droplet can hold itself together
Two very different types of quantum particles may be able to form stable droplets that hold themselves together, challenging decades of conventional thinking. The prediction could soon be tested experimentally and may reveal an unexpectedly rich world of new quantum phases.
Constitutional Politics in Action – Part I: The Petitions for the Constitutional Review of the 16th and the 17th Amendments of the Hungarian Fundamental Law
The Fidesz-KDNP parliamentary group submitted petitions to the Constitutional Court in July 2026 challenging Hungary’s newly adopted Sixteenth and Seventeenth Amendments. The petitions demonstrate how constitutional doctrine can be strategically reconfigured when political actors move from exercising constitutional power to challenging its exercise by others. After losing control of constitutional power, Fidesz strategically reconfigures elements of domestic doctrine that had been used to resist its own autocratization.
Chicago apartment sales jump 91% as rent growth draws investor confidence
Sales are bouncing back from a slowdown in recent years, when interest rate hikes that began in mid-2022 made larger deals more challenging.
How Florida is challenging climate change in textbooks, while quietly updating its science standards
Publishers acceded to state requests watering down information on climate change’s impact, WUSF/Hechinger Report investigation finds. Now the state has turned to updating its science standards.
Bill Maher rips left-wing lawmaker for sacrificing liberal values to appease Muslim voters
Bill Maher slammed Melissa Chaudhry, a progressive Democrat challenging Rep. Adam Smith in Seattle, for omitting LGBT rights to appeal to Muslims.
Community feeling impact of SF's Broadway Tunnel closures as major seismic upgrade project underway
Drivers, residents and business owners are preparing for a potentially challenging Monday commute as a major construction project at San Francisco's Broadway Tunnel gets underway.
U.S. commander calls mental health a priority after he visits USS Lincoln
Days after reports emerged of burnout and poor conditions aboard the USS Abraham Lincoln, Adm. Brad Cooper acknowledged that long stretches at sea can be challenging but that some of the concerns raised were 'old news."
US commander says mental health a 'priority' on USS Lincoln
Adm Cooper acknowledges service at sea for long periods is "uniquely challenging", after visiting the warship.
Healing Thyself: Managing Moral Injury in Healthcare
One of the most challenging parts of working in medicine is maintaining your own emotional health. New research on moral distress and moral injury offers clues on how we can better support healthcare workers.
5 Businesses Tech Workers Could Start With Their Existing Skills
Tech workers are facing a challenging job market. Here are 5 business options to consider if you’re interested in making the shift from job hunting into entrepreneurship.
Musk’s headaches: meet China’s corporate matrix challenging his empire
From Tesla to SpaceX, Starlink and Neuralink, Chinese companies are giving – or trying to give – Elon Musk’s firms a run for their money.
‘Am I losing my mind?’: the science behind why psychedelic trips can feel like you’re going insane
Neuroscientist Michal Dubrovinsky studies challenging psychedelic experiences and the moment people fear they are losing control, while exploring how psilocybin may affect brain flexibility and movement learning
Health advocacy group sues AMA to make billing codes public
PatientRightsAdvocate.org is challenging the doctor’s association’s copyright of the current procedural terminology, or CPT, system. Use of the codes is required by law, and that means they should be freely available, per the suit.
Dem Senate nominee admits 'I take responsibility' after police report alleges he broke down door, punched man
Troy Jackson acknowledged a 1988 fight as the NRSC calls on Senate Democrats to condemn the Democrat nominee challenging Susan Collins in Maine.
Jet-powered drones make up as much as two-thirds of some Russian attacks
Russia's jet-powered drones are more challenging to intercept than their predecessors powered by propellers.
Cardiologists develop new anchoring technique for challenging TAVR cases
TAVR can be especially challenging in patients with PAR and an enlarged LVOT. Specialists in China have developed a new technique that could improve outcomes for some of these patients without introducing new risks.
‘We are professionals’: Coalition of Public Service and Health Care Unions Sue to Block New Department of Education Student Loan Rule That Will Hurt Patient Care and Worsen Staffing Crises
WASHINGTON – A coalition of unions representing hundreds of thousands of public service and health care workers filed a lawsuit this week challenging the Department of Education’s new RISE rule.
Proven behavioral health navigation at scale: Inside Tufts Medicine’s playbook
Behavioral health conditions affect roughly 30% of patients, and these patients remain among the costliest and most challenging to guide to appropriate
Democratic rebellion against older politicians reaches new battleground
Former Hartford Mayor Luke Bronin, 47, is challenging Rep. John Larson, who is 78 and running for his fifteenth term representing Connecticut's first district.
AbCellera women’s health data top ‘most aggressive upside scenario,’ putting Astellas and Bayer on notice
AbCellera has reported phase 2 results “beyond even the most aggressive upside scenario” that its CEO dared to consider, boosting the biotech’s chances of challenging Astellas and Bayer for a women’s health market. The phase 2 clinical trial compared ABCL635, an antibody targeting NK3R, to placebo in patients with hot flashes caused by menopause. Investigators enrolled 92 postmenopausal women experiencing a mean of about 10 moderate or severe hot flashes per day. By Week 4, the number of moderate or severe hot flashes had fallen by a mean of 8.8 on ABCL635 and by 3.5 on placebo. That statistically significant, placebo-adjusted reduction of 5.3 hit the trial’s primary endpoint. The level of efficacy also cleared the bar set by existing drugs. While cross-trial comparisons can be misleading, AbCellera CEO Carl Hansen, Ph.D., had seen enough to start hyping the program. “We now view ABCL635 as a potential best-in-class non-hormonal therapy with strong differentiation against approved NK3R competitors across all important dimensions, including efficacy, safety, dosing and convenience,” Hansen said on a Monday morning conference call with investors to discuss the data. “We believe ABCL635 is now a highly de-risked program.” Last week, Hansen used AbCellera’s earnings call to set expectations for readout, with the CEO defining success as a clean safety profile and efficacy comparable to the two approved small molecules. The data vaulted over that bar. Astellas linked (PDF) one of the small molecules, Veozah, to placebo-adjusted reductions in hot flash frequency of 2.1 and 2.6 at Week 4 of its two phase 3 trials. Bayer reported (PDF) placebo-adjusted reductions of 3.04 and 3.29 at Week 4 of pivotal studies for its small molecule, Lynkuet. At 5.3, the placebo-adjusted reduction in AbCellera’s trial comfortably cleared the standard set by the incumbents. Veozah and Lynkuet came to market based on evidence of their ability to reduce the frequency and severity of hot flashes. AbCellera’s phase 2 study covered both endpoints, with the Canadian biotech reporting a mean reduction in severity of 1.4 points at Week 4 on ABCL635, compared to 0.3 points for placebo. Again, the placebo-adjusted result compares favorably to data on Veozah and Lynkuet. Analysts shared Hansen’s enthusiasm for the data. The phase 2 results “firmly validate ABCL635 as a potentially best-in-class treatment,” BMO Capital Markets analysts said in a note to investors Monday. ABCL635’s apparent efficacy edge “is likely attributable to the higher dosing/target engagement the asset is able to reach vs. the oral agents due to its wider therapeutic index,” the analysts added. The analysts, who model $2.3 billion in unadjusted peak sales for ABCL635, flagged the safety profile as another positive of the phase 2 readout. While Veozah carries a boxed warning for liver damage, nobody on ABCL635 in the phase 2 trial had elevated liver enzymes or bilirubin values. If replicated in phase 3, the lack of a liver signal could allow approval without the monitoring requirements imposed on Veozah. Investors appeared equally enthused, sending AbCellera's stock up 32% to $9.21 in premarket trading Monday from a Friday closing price of $6.93. Next, AbCellera will collect the Week 12 data and talk to its advisors about further development. The results open up “a wide variety of possibilities of how we might take this forward into phase 3 studies to truly maximize the value of the asset and make sure that ABCL635 is able to demonstrate its differentiation potential,” Sarah Noonberg, M.D., Ph.D., AbCellera’s chief medical officer, told investors.
How Troy Jackson went from Maine logger to the Democratic nominee for Senate
Troy Jackson's path to politics started during his time as a logger in Maine's north woods. Now he's the Democrat challenging five-term Republican Susan Collins for a Senate seat that could determine control of the chamber in November.
Science on Tap: The Evolution of NEST
What does it take to prepare for the nation’s most challenging nuclear and radiological emergencies?Discover the answer with the Nuclear Emergency Support Team (NEST), the National Nuclear Security Administration’s elite emergency response unit composed of leading scientists and technical experts.Join Michael Peters, NEST Director and Deputy Director for the Office of Nuclear Incident Response, as he takes audiences on a journey through the history of nuclear response in the United States. Explore the pivotal moments that shaped NEST, learn how the organization has evolved to stay ahead of emerging threats, and gain insight into the innovative approaches that continue to strengthen national security today.Whether you're interested in science, history, technology, or emergency response, this presentation offers a unique perspective on one of the nation's most important missions.Event Details:Friday, September 4, 2026 | Doors Open at 5:30 pm | Presentation at 6:00 pmLocation: National Museum of Nuclear Science & HistoryAdmission: $12 per personRequirement: Must be 21+ to attend. An adult must accompany younger guests.
A Promising Heart Drug Fails, Challenging a Long-Held Theory of Disease
The drug targeted inflammation, and its shocking failure has experts questioning whether inflammation really does cause heart disease.
Group files lawsuit challenging mobile sports betting law
Subhead under Facebook & Twitter headlines.
Former Attorneys General, Business Associations, and Former Department of Labor Leaders Support Family Farm’s Supreme Court Case
ARLINGTON, Va.—In its fall term, the U.S. Supreme Court will consider a lawsuit challenging the constitutionality of the Department of Labor’s agency court system. New […]
I Was Told I'm 'Just a Mom With a Side Hustle.' Here's What Those Words Reveal About Modern Business and Motherhood.
Motherhood is reshaping leadership, challenging outdated biases and redefining what it means to build a successful company.
Trump administration sued for banning gender transition treatments in federal health plans
An arm of the Human Rights Campaign launched a class-action lawsuit on Monday challenging the Trump administration’s gender-affirming care coverage ban in federal workers’ health insurance plans.&n…
Nvidia's CUDA faces new threats from AI coding agents
Nvidia has long dominated because of its CUDA software. Now, AI-driven software is challenging this moat as startups and giants innovate.
Milestones: Virginia companies going the distance
While the first few years in business are notoriously challenging for entrepreneurs, even milestones that seem achievable are still relatively uncommon.
No time to retire: Why growing older does not have to mean slowing down
Growing older should not mean withdrawing from life. By protecting our health, challenging our minds, and staying connected, we can continue to grow, learn, and find purpose at any age.