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British politicians among international delegates barred from entering West Bank
Group was on visit to meet Palestinian children, farmers and civil leaders facing escalating violence from Israeli forces
El Agave Mexican Restaurant opens in former Casa del Rey
Mexican cuisine has returned to the building that for decades was Casa del Rey.
FF EAI Robotics Ecosystem (FFR) Completes Acquisition of FFAI Robotics Business, Establishing a Nasdaq-Listed Humanoid and Bionic Robotics Platform October Robot Sales Expected to Exceed 300 Units; Unveils FF OmniMind, a Unified AI Brain for All Robots
FF EAI Robotics Ecosystem Inc. (NASDAQ: FFR) ("FFR" or the "Company") a U.S.-based Embodied AI robotics company, today announced at the deal closing and its first Investor Day event in New York that it has completed its acquisition of the robotics business and related assets of Faraday Future Intelligent Electric Inc. (NASDAQ: FFAI) ("FFAI" or "Faraday Future") on October 23, 2026. The related business operations and assets have been transferred to FFR, and FFR has issued and delivered common sh
Tom Brady, Candice Swanepoel have been dating since June: report
Football hero Tom Brady and supermodel Candice Swanepoel have reportedly been dating since June. The pair have kept the relationship quiet by spending time together in Indian Creek, Fla., 30
Microsoft offers voluntary buyouts to 60,000 employees as tech giant reshapes its workforce
Microsoft's voluntary buyout covers about 60,000 eligible employees, more than a quarter of its global workforce, across multiple countries.
Cisco IQ Is the Engine. Partners Are the Business.
Cisco IQ Partner Support – Standard is now GA. Partners can now deliver Cisco IQ as their own managed service and unlock new recurring revenue.
Ballon d’Or chaos as Harry Kane, Lamine Yamal and Kylian Mbappe published as winners on website
The official Ballon d’Or website posted the articles before the ceremony and has since deleted them
Emberville Delays Early Access Launch at the Last Minute
Cygnus Cross, the development team behind the promising "Diablo meets Stardew Valley" game Emberville, has delayed their Early Access launch the day before it was supposed to happen. The new Early Access release date is January 7 ,2027. To soften the blow the team says that the content originally planned for its first major post-launch update will now be included in the January 7 Early Access release.
MTSU recognized by Billboard among top music business schools for 12th year in a row
Billboard magazine names MTSU in its unranked annual report.
Three Injured Washington Commanders Return to Practice
Defensive end Charles Omenihu is one of three players the Washington Commanders saw return to practice on Monday ahead of the week eight primetime meeting against the Philadelphia Eagles
Billy Corgan says 25-year age gap with wife was ‘an advantage’ because she wasn’t ‘wounded’ like older women
The couple met in 2012, when Corgan was 44 and Chloé Mendel was 19.
How Eaton’s (ETN) Data Center Business Complements Amphenol’s AI Infrastructure Opportunity
Burke Wealth Management, an investment management company, released its “Focused Growth Strategy” Q3 2026 investor letter. A copy of the letter can be downloaded here. The fund delivered strong results in the third quarter of 2026, benefiting from a sharp recovery in enterprise software and solid corporate earnings amid continued market volatility. The composite returned […]
Colton Dixon offers Christian response to Halloween with haunting new song ‘Bones’
Colton Dixon is putting a faith-filled spin on Halloween with his new single, Bones, using skeletons, graveyards and other spooky imagery to deliver a message about spiritual authority and God s
Manchester United Make Leipzig Captain David Raum A Top Target
The Red Devils are eyeing a cut-price move for the German international, leveraging a delicate contract standoff to bolster their backline against competition from Juventus and Barcelona.
Is Rayquaza Broken? Delta Reign Set Preview
Our new set Delta Reign is getting some hype because of the crazy new engine based around Mega Rayquaza ex. This deck is clearly good, and it's already
More women are dying from heart disease. New guidelines for doctors aim to change that.
Heart disease is the No. 1 killer of women in the U.S. — a threat that's projected to rise significantly over the next two decades. A new approach to care hopes to change that.
More women are dying from heart disease. New guidelines for doctors aim to change that.
Heart disease is the No. 1 killer of women in the U.S. — a threat that's projected to rise significantly over the next two decades. A new approach to care hopes to change that.
Review: The Whyte Sythe RS Delivers High-End Suspension at a Reasonable Price
A dependable option for steep, technical terrain.
Announcers Revealed for Steelers-Browns Game
CBS revealed that Kevin Harlan (play-by-play), Trent Green (color) and Melanie Collins (sideline) will be on the call for the […]
Snap counts: Secondary rotation leads to success vs. Packers
The Detroit Lions delivered an inspired secondary rotation to limit the Packers’ passing attack.
Who's In Charge? The Faces Of Serbia's Student-Backed Political Movement
The Students' List, a political grouping of 250 representatives that just won Serbia’s parliamentary elections, has deliberately avoided having a clear leader. While it remains uncertain who Serbia’s prime minister will be, here are some of the high-profile Serbians representing the movement.
Owners of Elvis Presley’s music sue Anthropic over un-permissioned AI use
The owners of Elvis Presley’s music are suing Anthropic for using the rock icon’s songs without permission to train AI models. Much has been made of the theft component inherent
📈 Monday data: The bottleneck isn’t intelligence
In the AI Investment Brief today: CapEx updates and lease commitment breakdowns Anthropic co-founder Jack Clark recently said in a speech at the IMF that the singularity has begun: For many years, researchers and science fiction authors have forecast a future in which AI systems drastically increase the pace of overall scientific and technical progress, making things move so quickly that it is hard for humans to keep up. They call this the singularity. I believe that this year we have gained convincing evidence that it has now begun. This follows Anthropic’s claim that in August, 26% of its AI R&D was led by Claude, with a human supervising its work. In October, OpenAI posted 719 math manuscripts1 made by its internal model. Math and coding are two fields where a research loop can close without leaving the desk. But can the loop close in the rest of science? Subscribe The loop is real The idea is not new. Mathematician Irving John Good, who had worked with Alan Turing at Bletchley Park, argued that a machine smarter than us “could design even better machines; there would then unquestionably be an ‘intelligence explosion,’ and the intelligence of man would be left far behind.” The Gödel machine, a self-improving computer that can rewrite its own code better than its prior, was first proposed in 2003. In 2025, researchers at Sakana AI and the University of British Columbia set out to show that this was possible. Their agents iteratively improved their own code through a feedback loop, resulting in gains of 30 pp on SWE-bench and more than 15 pp on Polyglot, testing coding skills beyond Python. The idea has since been tested in other labs. A Gemini-powered agent called AlphaEvolve found a faster matrix multiplication kernel used for training Gemini, speeding up the kernel by 23% and cutting Gemini’s training time by 1%. In China, MiniMax reported that its M2.7 model worked on improving its own agent’s harness, skills, sampling and memory. Over 100 rounds of rewriting led to a 30% gain, per its internal evaluations. In each case, what was being rewritten was not the model itself but everything around it. Is it better than human work? In September this year, in what seemed like a milestone, an AI-built agent proved as good at improving other AI agents as a human-built one. It did that in what appeared to be half the steps. But the result was inconclusive: the differences between runs were greater than the difference between the AI- and human-built agent results. Nonetheless, this is increasing the chatter around recursive self-improvement (RSI) in AI. Google’s Sundar Pichai said that “you have RSI loops along with AI researchers in various aspects of model development.” Sakana AI published a paper on RSI through multi-agent collaboration, finding that after two cycles its system scored 1.2–1.6x better per output token than the base model across four research benchmarks. Ramez Naam challenges that view. He splits AI self-improvement into five overlapping types. The first four describe how autonomous the AI is; so far, only types 1 and 2 have been observed. The fifth type describes accelerating returns, and he notes that greater autonomy doesn’t guarantee a takeoff scenario. Instead, each round of self-improvement would need to deliver at least as much as the last. The results from Sakana, AlphaEvolve and MiniMax above might look like type 3 or type 4 autonomy. But in each case, the AI wasn’t updating its own weights directly, only the ancillary parts — the harness, the memory. And where Claude leads its own R&D, for now a human still supervises.
Scientists Tested a Toad Venom Psychedelic on Treatment-Resistant Depression. Here's What Happened.
A clinical trial shows promising results, but many questions remain.
Cardiovascular Health in Girls and Women Compendium
Prevention and management of cardiovascular disease in women needs a new organizing framework. Cardiovascular disease remains the leading cause of death in women and accounts for 1 in 3 deaths, yet women’s cardiovascular care has been fragmented across specialties, life stages, and clinical guidelines, leaving female-specific risk under-recognized and inconsistently managed.
Side expands presence in China, opens new studio and acquires art outsourcing provider Roboto Entertainment
Roboto Entertainment founder Andrea Cordella appointed global head of art and studio head for new Chengdu office
Converting PSVs for Expedition Cruising Creates Compelling Business Model
Architect and yacht designer Stefano Pastrovich has developed a novel concept that he believes can create a compelling business model and entry for bo...
New zebrafish models could help test treatments for mental health conditions
A humble fish can experience features of mental health conditions such as schizophrenia and autism, raising the possibility that some of our most complex social behaviors may be more deeply encoded in ...
Daymark Health Oncology, Palliative Model Reduces Hospitalizations, Costs
An in-home and virtual supportive oncology care program by Daymark Health was associated with fewer hospital admissions and lower overall health care
Quantum Art Research Outlines More Efficient Quantum Approach to Wave Modeling
Insider Brief Quantum Art presented research on a quantum algorithm that uses known wave physics to simplify large-scale wave simulations, with potential
Some iPhone Duo Models Are Breaking. iFixit’s Teardown Might Explain Why
The repair company iFixit released its repairability rating for Apple’s very first foldable iPhone. It comes as users report a wave of cracked-screen issues.
Scientists Built a Virtual ‘Torture Chamber’ for AI. What It Revealed Is Deeply Unsettling.
Researchers searched for a signal of pain inside large language models—and they may have actually found one.
In brief: Orlando Bloom, Elijah Wood joining 'The Gentlemen'
Netflix is rounding up more gentlemen. Tudum announced Orlando Bloom, Elijah Wood and Ed Speelers are joining stars Theo James and Kaya Scodelario for the third season of The Gentlemen, which is currently filming in the U.K. and Morocco. Also added to the series cast are Dexter Fletcher, Robert Carlyle and Bugzy Malone, who appeared in the 2019 film that inspired the Netflix series. Daniel Ings, who played the drug-addled older brother Lord Frederick “Freddy” Horniman to James’ criminal mastermind Eddie Horiman, told HATC magazine he will not return for the third season. Netflix has not confirmed this …The action-adventure series Fallout has inspired a new reality show. Prime Video has revealed Fallout Shelter: The Experiment, an unscripted competition inspired by the post-apocalyptic drama series and the video game universe. The show “invites everyday participants to test their aptitude for the apocalypse in Vault-Tec's state-of-the-art bomb-proof vault shelters," according to Prime Video. Contestants will “go head to head in a series of high-octane drills, psychological dilemmas and morally challenging behavior trials.” The winner walks away with a $1 million prize. Fallout Shelter: The Experiment will begin streaming in January 2027 … TNCMS.AdManager.render({region: 'fixed-big-ad-top-asset', slot: 1, fold: "above"}); Bravo renewed a slate of its reality shows ahead of Bravo’s Fan Fest on Saturday. New York-based In the City has been greenlit for season 2, while Next Gen NYC is coming back for a third season. For viewers seeking a little Southern charm, The Next Gen universe will be expanding with a spinoff based in Atlanta, and Southern Hospitality is moving forward with a fifth season. Premiere dates have not yet been announced … Copyright © 2026, ABC Audio. All rights reserved. Thank you for reading kmaland.comAt KMA, we attempt to be accurate in our reporting. If you see a typo or mistake in a story, please contact us by emailing kmaradio@kmaland.com.
A Dead Salmon's Fake Brain Activity Still Haunts Science, and AI Tools Can Fall for the Same Trap
A dead salmon once showed fake brain activity on an fMRI scan. Now AI researchers say tools that explain AI models face the same statistical trap.
Inside Business 2026 Top Forty Under Forty: Davis Watson, Ferguson
Davis Watson is the national head of Waterworks Digital Delivery at Ferguson Enterprises.
Purdue and Accenture: A model for applied partnership
Artificial Intelligence is reshaping every industry. Find out how Purdue and Accenture are working together to prepare Indiana’s workforce and students in Purdue’s Mitch Daniels School of Business for an AI-powered future.
UN climate science body left in limbo without budget sign-off after deadlock
Stranglehold on funding for the IPCC follows push from fossil fuel-reliant nations to delay publication of global warming reports
Walmart taps startup General Medicine to expand Better Care Services
Walmart is teaming up with startup General Medicine to expand its Better Care Services, turning the digital healthcare platform into a more comprehensive healthcare marketplace. | Walmart is teaming up with startup General Medicine to expand its Better Care Services, turning the digital healthcare platform into a more comprehensive healthcare marketplace.
NASA Plans Faster, Cheaper Picks for Space Science Missions: What Changes
NASA says its new Competition Model 2.0 will cut the time to pick some science missions from 35 months to about 19.5 and make small missions a one-step process.
CleanYourTV 3.0 Lets You Remove Ads And Bloatware From Android And Google TVs, Now Supports 300 Models
CleanYourTV 3.0 enhances smart TV experience with ad-blocking, compatibility for 300 models, and an easy phone setup, gaining 37,000+ GitHub stars.
New Allied Health Concentration Fuses Healthcare Delivery with Emerging Technologies
The new Digital Health and Technology concentration gives UConn students firsthand experience with the tools transforming modern healthcare and build skills ...
Inside Business 2026 Top Forty Under 40: Julius Delbridge, CHKD Sports Performance Academy
Julius Delbridge is the fitness program supervisor at CHKD Sports Performance Academy.
Inside Business 2026 Top Forty Under 40: Julius Delbridge, CHKD Sports Performance Academy
Julius Delbridge is the fitness program supervisor at CHKD Sports Performance Academy.
Political consultant on the impact of Republicans' gerrymandering efforts
NPR's Leila Fadel speaks with political consultant Mike Madrid about how Republicans' gerrymandering efforts have backfired.
Dallas Cowboys vs. Philadelphia Eagles: How to watch Monday Night Football tonight, start time and where to stream
Exclusive-US Political Candidates Tailor Messages for AI Models Used by Voters
By Mike Stone WASHINGTON, Oct 26 (Reuters) - US political candidates have been engineering their campaign messages to appeal to the AI chatbots that more voters have been using to answer questions about issues, and documents seen by Reuters have revealed some of their strategies. One Powerpoint ...
Is Eli Stowers playing Monday? Latest Eagles injury update
Eli Stowers is listed as questionable against Dallas after a full practice week as the rookie tight end works back from a quadriceps injury
Is Saquon Barkley playing Monday? Latest Eagles injury update
Saquon Barkley is listed as questionable against Dallas after returning to full practice Saturday. Here’s the latest on his hamstring injury
Unlocking the mystery behind election polling
Political polling has been a staple of election season for hundreds of years. But recently, a lot of polls have missed the mark — widely. We take a look at how polling is done in Florida.
Groundbreaking Guidelines Released for Women’s Heart Health
The guidelines, which were authored by four major medical groups, are a framework for how hormonal changes up heart disease risk from puberty to after menopause.
Micro1 invests $1B to license data for AI model development
Micro1 is pledging $1 billion to gobble up more companies' internal data for licensing to AI model developers, part of a new wave for the tech.
New Orleans-based biotech company lured to SC as first for MUSC lab
The company name was deliberately chosen from West African lore: Obatala, the god who shaped the human body. And the New Orleans biotech firm is determined to see that their human-based research lab m...
What to know about the five phases of women’s and girls’ heart health
Several major medical organizations released coordinated guidelines for female heart health, spanning puberty to perimenopause.
Smithsonian scientists launch "Lumina" simulation to model early universe
Researchers introduce "Lumina," a massive cosmological radiation-hydrodynamics simulation designed to model the universe's first two billion years
Today’s Papers: Juventus claw back, Inter never give up
La Gazzetta dello SportKimi, here we go Another triumph, the World Championship will arrive on Sunday with a ninth-place finishAntonelli also dominates at the GP in Austin: His ninth victory. The tit...
Torquay's 'Prince of Plainmoor' Stubbs dies aged 85
Robin Stubbs - widely regarded as one of Torquay United's greatest-ever players - dies aged 85.
Pa., N.J. and Del. to kick off 2027 ACA health insurance open enrollment on Nov. 1 as health costs rise: What you should know
ACA customers may face higher premium prices for coverage next year, but insurance experts say most people still qualify for financial assistance.
Clune Construction: The discipline and adaptability behind our growth
Clune Construction scales nationally through innovation, employee ownership and consistent project delivery while preserving its culture.
Seahawks Jaxon Smith-Njigba Delivers Simple Message After Beating Chiefs
Seattle Seahawks wide receiver Jaxon Smith-Njigba had a simple message after his team beat the Kansas City Chiefs. The post Seahawks Jaxon Smith-Njigba Delivers Simple Message After Beating Chiefs appeared first on HEAVY.
Local shops welcome costumed crowds ahead of Halloween
The Volkswagen parking lot was delightfully frightful on a spooky Saturday. Kids of all ages had a chance to test run their Halloween costumes, collect
12 AI models were asked what they really think about humans — and almost all agreed on one uncomfortable truth
29 of 35 responses shared the same theme
‘Been a Problem for a Very, Very Long Time’ — Revisiting the Time Fox’s Pam Oliver Revealed the Health Battle That Impacts Her Sideline Reporting
NFL sideline reporter Pam Oliver has been a fixture in the business for more than 30 years, covering the league for Fox. At 65, she’s also one of the most experienced voices on the sidelines, most recently covering the San Francisco 49ers’ Week 7 matchup against the Atlanta Falcons.
Minsu Kim's stance on Rangers transfer revealed
Minsu Kim in action with Derek McInnes on sideline left inset
Aaron Gordon Praises David Adelman's New System
Aaron Gordon is the perfect piece for David Adelman's new system.
How Functional Foods Deliver Bioactive Compounds and Support Gut Health
Functional foods use delivery systems such as encapsulation, lipid carriers, and hydrogels to protect bioactive ingredients and control their release during digestion. These technologies may improve nutrient availability, but human studies are needed to establish their health benefits and long-term safety.
Marco Rubio’s Greek Panegyric / Celebration: Political Theory and Praxis
Prologue Translating the ideals of Greek history, politics, democracy, theater, athletics, the Delphi peace vision, philosophy, science, technology,
Women’s football’s Black British icons
Our writers pay tribute to the Black British women who have left indelible legacies on the sport
76ers veteran briefly raises alarm with injury scare vs. Pistons
The injury hits kept coming around the NBA on Sunday evening , but the Philadelphia 76ers seemingly avoided catastrophe with veteran guard Kentavious Caldwell-Pope. The veteran guard exited the game briefly , as per Adam Aaronson of The Philly Voice, with an apparent injury. While was initially tended to by team staff and accompanied back to the […] The post 76ers veteran briefly raises alarm with injury scare vs. Pistons appeared first on ClutchPoints.
Lula is declared winner of Brazil's election as Bolsonaro rejects results
Flavio Bolsonaro is refusing to concede defeat to incumbent President Luiz Inácio Lula da Silva, who bested him by nearly 4.4 million votes, following a chaotic delay in poll closing
Observations after shorthanded Sixers fall to 1st loss of season
The shorthanded Sixers fell to their first loss of the season on Sunday night.
Player grades: LeBron James returns, but Sixers fall to Pistons
LeBron James returns, but the Philadelphia 76ers fall to the Detroit Pistons at home on Sunday night.
Politics Unplugged (Full Episode) Oct. 25, 2026
On this week's episode of Politics Unplugged, host Dennis Welch and a panel break down Arizona's election landscape one week out: pessimistic voter mood, suppressed independent turnout, lagging GOP enthusiasm, and Democrats gaining ground. They discuss Elon Musk's late spending in competitive House races and debate the impact of big money flooding the state. The show also covers a widely condemned Ohio attack ad by Vivek Ramaswamy that weaponizes a rival's childhood abuse—drawing praise from Trump and Vance but bipartisan outrage.
Scientists discover Arctic sea ice loss could be far worse than predicted
Arctic winter sea ice could disappear much faster than scientists previously expected, according to new research using climate clues from 6,000 years ago. By comparing ancient ocean sediments with modern climate models, researchers found that future winter ice coverage may be roughly one million square kilometers smaller than earlier predictions suggested.
Women Appear to Experience Psychedelic Drugs More Intensely, And We Don't Know Why
Same dose, different experience.
How Obama and Trump Made their Cases in Dueling Midterm Speeches
At rallies this weekend, Mr. Obama and Mr. Trump delivered two starkly contrasting pitches, differing in style and substance.
“Odegaard was outstanding” but Merson was less complimentary about Gyökeres
Paul Merson has delivered contrasting verdicts on two Arsenal players following Saturday’s comfortable 2-0 victory over Everton, singling out Martin Ødegaard for praise while questioning Viktor Gy�...
Pistons' Ausar Thompson ruled out against Sixers
The Pistons will be without Ausar Thompson on Sunday night for their match against Philadelphia.
Lawmakers propose $11M fix to restore school sports and activities funding
by Katie Klingsporn, WyoFile Wyoming’s new school funding model added more than $250 million in state education funding, including for widely supported
How Pratt Proved Brewers Right in the World Series
Shrugging off an early error, rookie Cooper Pratt delivered a clutch game-winning hit, vindicating the Milwaukee Brewers long-term investment.
Primark's Business Doesn't Make Sense
In a world where fast fashion giants like Shein, Zara, and H&M drop thousands of new styles every day — and rake in billions through e-commerce — Primark is doing the unthinkable: thriving with zero online shopping. So what gives?*Want to Know the 5 Trends Changing Modern Retail? Find Out Here:* 🔗 https://clickhubspot.com/d13ac2In this video, we take you inside Primark’s weirdly brilliant business model — a model that’s stuck in the past on purpose. From warehouse optimization and floor-ready freight shipments to why the pandemic didn’t push them online, we unpack how this low-cost retail giant has managed to defy digital norms… and make it work.This isn’t just about one brand. It’s a story about modern retail expectations — and what it actually takes to meet (or reject) them.Subscribe to The Hustle:🔗 https://clickhubspot.com/vu3lGet the 5-minute newsletter keeping 2M+ innovators in the loop🔗 https://clickhubspot.com/3klnAbout HubSpot: HubSpot is a customer platform that provides education, software, and support to help businesses grow better. The platform includes marketing, sales, service, commerce, operations, and website management products that start free and scale to meet our customers’ needs at any stage of growth. Today, thousands of customers around the world use HubSpot’s powerful and easy-to-use tools and apps to attract, engage, and delight customers.#TheHustle #HubSpot
Queen of Halloween Heidi Klum teases costume with mysterious image
“What’s my costume?,” the model asked fans alongside a strange close-up photo.
‘There's a risk we do have a disconnect’: Business on Australian Labor
Chamber of Commerce CEO Andrew McKellar appears to suddenly be everywhere, all at once.
Unpatched Tailscale SSH Flaws Could Let a Hacked Device Reach Root on Other Servers
Unpatched Tailscale SSH flaws could let attackers gain root on permitted servers from a compromised device when port forwarding is enabled.
Health care shakes up the Iowa election
If Democrats flip Congress, health care could find its way to the top of their 2027 agenda.
Apollo: AI has delivered 'zero financial payoff' to corporate America
Only tech companies are seeing growth from the AI boom, Apollo Global Management said.
John Sununu is running on his family’s legacy in New Hampshire. His brother is staying on the sidelines
The campaign signs across New Hampshire read “Sununu” in block letters.
Game Time Thread: Juventus vs. Lecce
MATCH INFO When: Sunday, Oct. 25, 2026. Where: Stadio Via del Mare, Lecce, Italy. Official kickoff time: 6 p.m. local time in Italy and across Europe, 8 p.m. in the United Kingdom, 1 p.m. Eastern time, 12 p.m. Central time, 10 a.m. Pacific time. (Please note that the fall time change in Italy goes into effect on Sunday, […]
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
South Texas Health System (@stxhealthsystem)
1 likes, 1 comments - stxhealthsystem on October 25, 2026: "Exceptional Care Starts With You: Nurses play a vital role in every patient journey, providing the compassionate, skilled care that helps make South Texas Health System’s 12 facilities a trusted healthcare resource for communities across the Rio Grande Valley. If you're passionate about making a difference and delivering exceptional patient care, now is your opportunity to join the largest integrated healthcare network in the region. STHS is seeking dedicated and compassionate registered nurses to join its team at four acute care hospitals, a behavioral health hospital and seven freestanding emergency departments. Become part of a team committed to clinical excellence, collaboration and compassionate care. To view current openings and apply, visit the STHS careers page at the link in our bio.".
Laramie County health and food inspections (10/16/26–10/22/26)
CHEYENNE, Wyo. — The Cheyenne-Laramie County Health Department inspects restaurants, bars, convenience stores, delis, grocery stores, bed and breakfasts
Arch Manning has another viral moment with ESPN's Holly Rowe
The Texas quarterback was happy to see Rowe on the sidelines.
Preview
The Men's First Team are back in Serie A action, this time heading south to face Lecce in Puglia.The Serie A Matchday 8 clash is set to take place at the Stadio Via del Mare at 18:00 CET on Sunday, Oc...
Argument over purchase turns physical; suspect pulls gun at South Side business
KABB Fox News 29 San Antonio provides local news, weather forecasts, traffic updates, investigations, notices of events and items of interest in the community, sports and entertainment programming for San Antonio and nearby towns and communities in South Central Texas, including Bandera, Boerne, Carrizo Springs, Castroville, Cibolo, Converse, Crystal City, Cuero, Del Rio, Devine, Eagle Pass, Floresville, Fredericksburg, Goliad, Helotes, Hondo, Kerrville, Live Oak, New Braunfels, Pearsall, Pleasanton, Poteet, Poth, Sabinal, San Marcos, Seguin, Schertz, Somerset, Universal City, Uvalde, Windcrest.
Argument over purchase turns physical; suspect pulls gun at South Side business
WOAI NBC News Channel 4 San Antonio provides local news, weather forecasts, traffic updates, investigations, and items of interest in the community, sports and entertainment programming for San Antonio and nearby towns and communities in South Central Texas, including Windcrest, Uvalde, Universal City, Somerset, Seguin, Schertz, San Marcos, Sabinal, Poth, Poteet, Pleasanton, Pearsall, New Braunfels, Live Oak, Kerrville, Hondo, Helotes, Goliad, Fredericksburg, Floresville, Eagle Pass, Devine, Del Rio, Cuero, Crystal City, Converse, Cibolo, Castroville, Carrizo Springs, Boerne, Bandera.
Physician Mental Health and Health System Privacy: Why Doctors Avoid Their Own EHR
In most organizations the default access model was built for patient care, not for protecting colleagues. A nurse on another unit, a resident who rotated with them, a department administrator: any of them may technically be able to open the record, even when policy says they should not.
U of M fellowship aims to boost rural obstetrics training and keep labor and delivery units open
The partnership is launching the new, one-year family medicine obstetrics fellowship next summer to prepare family medicine physicians to provide advanced prenatal, maternity and newborn care in rural communities. The only other fellowship of this kind in Minnesota is at Essentia Health in Duluth.
Health Ministry announces national clinical trial of psychedelic substances for treatment of PTSD
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