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Everton leading the race to sign Middlesbrough’s Hayden Hackney
Everton have emerged as frontrunners to sign Middlesbrough midfielder Hayden Hackney. The 23-year-old deep-lying playmaker enjoyed a superb 2025–26 campaign, scoring five goals and providing eight a...
Michigan coach Kyle Whittingham takes wild IndyCar ride
Michigan coach Kyle Whittingham enjoyed a high speed ride at the Detroit Grand Prix despite some rivalry ribbing.
Castleton moving sports to MASCAC
CASTLETON, Vt. (WCAX) - After nine years in the Little East, Castleton is moving the majority of its athletic programs to the Massachusetts State Collegiate Athletic Conference. 20 of the 26 Spartans sports programs will move ahead of the 2027-28 school year. Castleton previously played one football season in the MASCAC before joining the New Jersey Athletic Conference ahead of the 2025 season. The MASCAC currently includes seven state universities from Massachusetts. Castleton replaces the one private member, Anna Maria College, as it shut down permanently at the end of this school year. There are a few hurdles Castleton will have to figure out: while four of the six sports not joining the MASCAC don’t participate in a traditional collegiate conference, the tennis programs will likely need to find affiliate memberships to build schedules. And Castleton will have to schedule rival Norwich as part of its nonconference hockey slate...but athletic director Tim Barrett says it’s the right move for the Spartans, especially when it comes to football. “We’ve had ongoing conversations for the last couple of years regarding the possibilities within the MASCAC,” Barrett said. “Obviously, we had the one year relationship for football in the MASCAC, we enjoyed our time there, we felt at that point we were a natural fit for that conference. So we’re looking forward to it, we’re also looking forward to the next seasons within the Little East Conference, but I do think this was the right move at the right time.”
Yerba mate has lots of health benefits but Chinese may be drinking it wrong
Ancient South American fusion may reduce risks of Parkinson’s and is enjoyed by top footballers, but the indigenous drink should be shared.
Licensable picture: In this Feb. 24, 2004 photograph, Abilene Reporter-News entertainment writer Brien Murphy and KTXS sportscaster George Levesque
In this Feb. 24, 2004 photograph, Abilene Reporter-News entertainment writer Brien Murphy and KTXS sportscaster George Levesque discuss what they enjoyed and...
Azzi Fudd’s third-quarter takeover lifts the Wings past the Liberty
Fudd always enjoyed playing at Barclays Center when she was in college at UConn, so it was no surprise that she had the best game of her young pro career there.
Nottingham Forest v Bournemouth: Key stats and talking points
Bournemouth visit Nottingham Forest on Sunday knowing they are already assured of a first European adventure next season – but they need a number of results to go their way to land a place in the Champions League. It was Forest who enjoyed their own continental quest this year, with an impressive run to the Europa League semi-finals providing a welcome distraction to their domestic woes. Vitor Pereira took over from Sean Dyche in February and has steered the Tricky Trees to safety thanks in no small part to an eight-game unbeaten run that ended with a 3-2 defeat by Manchester United last week.
Bond breakout? Big effects of bad data. Immigration and thermostatic politics & dad-chat is coming for dad-books.
Thank you for opening your Chartbook email. Anna Airy, A Shell Forge at a National Projectile Factory, Hackney Marshes, London, 1918 Bond breakout - John Authers Across the developed markets, bond markets are staging a slow-motion car wreck. Looking at the drastic moves in the US, Japan, the UK and France, Barclays’ Ajay Rajadhyaksha commented: “Last week, long bonds broke. Not in one country. In all of them. Simultaneously. Four countries. Four different political systems. Four different central banks. But the same trade — “get me out of duration!”” Each country has its own contributing political problems, but the uniformity of the shift out of long-term bonds with high duration makes clear that something broader is afoot. For Rajadhyaksha, it is “simple and uncomfortable.” The developed world “has too much debt, too little fiscal discipline, and no political appetite for fixing either.” If there’s a trigger, it has been the Iran war and the resulting shock to oil supply. Source: Bloomberg G7 countries are now borrowing at rates that were enjoyed by EM in the early 2020s For contributing subscribers only. Subscribe Trade between China and Russia has grown in recent years For contributing subscribers only. Subscribe Big effects of bad data A decade ago nearly nine in ten Americans, when approached, agreed to fill out the Current Population Survey, which is administered to about 60,000 households each month and asks about, among other things, employment. Fewer than seven in ten do so now (see chart 1). For the Consumer Expenditure Survey, which tries to capture 3,700 households monthly, the response rate is down from 68% to 40%. … When the information becomes less reliable, investment decisions get more difficult to make. Some may be delayed, creating a potential drag on the economy. A new working paper by Nicholas Bloom of Stanford University, Erica Groshen, former head of the Bureau of Labour Statistics (BLS) now at Cornell University, and Duncan Hobbs and Michael Strain of the American Enterprise Institute, a think-tank, hazards an estimate. Preserving trust in “the integrity and quality of official statistics”, the authors claim, generates economic benefits of about $25 for every $1 spent on the BLS, the agency with an annual budget of $700m that is responsible for many of these data. To arrive at their conclusion the quartet analysed an ignoble episode in the BLS’s recent history. On August 1st 2025 Donald Trump sacked Erika McEntarfer, appointed as the agency’s commissioner by his predecessor, Joe Biden. The president alleged, without evidence, that the BLS’s steep downward revision to recent jobs numbers had been “RIGGED in order to make the Republicans, and ME, look bad”. In fact, it was the wanton dismissal that looked bad in the eyes of many observers. In the following seven days there was a 50% leap, relative to the week before, in the average value of the index of Economic Policy Uncertainty (EPU), which tracks the number of articles mentioning such uncertainty that are published daily in American newspapers. This was a discernible jump even when compared to the chaos caused by Mr Trump’s trade war in April 2025 and his real one in Iran in the past two months (see chart 2). Based on Mr Bloom’s earlier study with other colleagues of the EPU’s impact on business investment, industrial production and employment, the authors estimate that the jump reduced American GDP by over $100bn (0.3%) and non-farm payrolls by 168,000 (0.1%). Source: The Economist Immigration and thermostatic politics (Sarah O’Connor in the FT) A strange thing happened a year and a half ago. No sooner had Americans elected Donald Trump as president on an explicitly anti-immigration platform than US public opinion began to swing much more favourably towards immigration. … to political scientists who study “thermostatic” politics, this development is no surprise at all. Public opinion often moves against the prevailing party, especially if they are perceived to have gone “too far” in one direction. The phenomenon was first explored in the 1990s with reference to fiscal policy, but in recent years it has been particularly evident in the realm of immigration policy. While these swings in opinion polls can make it seem as if people don’t know their own minds, they can be a useful democratic check on governments by sending bright flashing warning lights when policies stray too far from the public’s comfort zone. The problem comes when politicians misinterpret those signals. When people tell pollsters they want less immigration, or think it is bad for the country overall (or the converse), they are often expressing an opinion about how things appear to be going in that moment relative to their preferences, rather than a deep shift in their underlying views. According to Alexander Kustov, a political scientist, most Americans’ views are quite stable and moderate: they support immigration that is controlled and in the national interest, and oppose flows that are disorderly or under-enforced. In the US, he argues the Trump administration over-interpreted dissatisfaction with high immigration under Joe Biden, and implemented policies that went too far for many voters. “People don’t necessarily change their idea about their ideal immigration policy, but they can react to what the government is currently doing,” he told me. “A lot of people are not happy with what the Trump administration are doing — right now we’re not talking about border enforcement, we’re talking about people not just getting harassed, but killed.” But similarly, he added, pro-immigration advocates would be making a mistake to interpret the recent, more favourable swing towards immigration as a deep-seated ideological shift in attitudes. The recent history of UK immigration policy offers another cautionary tale. After the 2016 Brexit referendum, public concern about immigration fell. This was partly because net migration statistics declined, but also because people felt a sense of catharsis and control, says Sunder Katwala, director of British Future, a think-tank. By 2019, the public ranked immigration as only the ninth biggest issue of concern, according to Ipsos polling. But when the Conservative government liberalised visa routes for students and care workers between 2019 and 2022, that helped net migration to surge. And so, too, did public concern. Today’s Labour government has implemented another sharply restrictive turn in immigration policy. As Kustov and researcher Caitlyn Yates argue, thermostatic public opinion should be a useful check on politicians. Instead it seems to have helped to magnify the pendulum swing in the UK. The government over-interprets and overreacts to a change in public opinion, which reacts in turn, prompting a sudden swing the other way. Source: Financial Times HEY READERS, THANK YOU for opening the Chartbook email. I hope it brightens your day. I enjoy putting out the newsletter, but tbh, what keeps this flow going is the generosity of those readers who clicked the subscription button. If you are persuaded to click, please consider the annual subscription of $50. It is both better value for you and a much better deal for me, as it involves only one credit card charge. Why feed the payments companies if we don’t have to. Subscribe Anna Airy, Shop for Machining 15-Inch Shells: Singer Manufacturing Company, Clydebank, Glasgow, 1918 Racing for a vaccine … we have been here before! The deadly Ebola outbreak in two African countries driven by a virus species with no vaccine has triggered an urgent search for a potential jab, in a test of troubled global efforts to avert threats posed by emerging diseases. A World Health Organization advisory group is due to would meet on Tuesday to recommend candidate jabs to prioritise for clinical trials, the global health body said. It will assess data including an analysis by the Coalition for Epidemic Preparedness Innovations (Cepi), which was set up after failures in the international response to a previous Ebola crisis. The latest Ebola outbreak in Democratic Republic of Congo and Uganda has infected hundreds of people and killed more than 80, health authorities say. Cepi’s reaction will be a crucial indicator of its progress towards its wider goal of producing vaccines for pandemic threats in just 100 days, despite steep cuts to international health funding. “If there was ever a time that we could show the world why Cepi is needed and show the world why the 100-day mission is needed, it’s now,” Nicole Lurie, the organisation’s executive director for preparedness and response, told the FT. “We’re happy to accept that responsibility, but obviously we need help from partners — particularly financial help in the long run.” DR Congo and Uganda would make the final decision on whether to press ahead with any vaccine candidates endorsed for clinical trials by the WHO experts, the global health body said. “Other ethical and community acceptability issues will be considered,” said the WHO, which declared the latest outbreak a public health emergency of international concern on Sunday. “This will be important to make sure that the trial, if it happens, will be adequately communicated to the population.” Lurie said Cepi had provided information from a survey of research teams and companies working on drugs that might be effective against the Bundibugyo virus behind the outbreak. The organisation hoped soon to announce partners in the quest for a jab, she added, although she declined to give a timescale for when one might be developed. Cepi’s Nicole Laurie said global health bodies were ‘getting some live-fire drills’ with hantavirus and the latest Ebola outbreak. The hunt for a vaccine should be helped by scientific advances including the use of artificial intelligence to find drugs active against viruses, Lurie said. Existing jabs against the Zaire Ebola virus responsible for many previous outbreaks might provide a basis for tackling the Bundibugyo species, she added. “We’ll see how far and how fast we can get,” Lurie said, adding that Cepi had done preliminary work recently on a possible jab for the rat-borne hantavirus responsible for a recent fatal outbreak on a cruise ship. “Both with hantavirus and now with Ebola, [we] are getting some live-fire drills.” Source: Michael Peel in the Financial Times Dad-chat is coming for dad-books. (By Pamela Paul and Jeffrey A. Trachtenberg in the WSJ) They were the go-to gifts for Father’s Day: a book about some little-known chapter of World War II, the sweeping narrative of a shipwreck, perhaps the latest presidential biography. These days, dad books are a dying breed. Nonfiction book sales have been in decline for the past four years, and are now the most challenged segment of the print book market. Publishers say certain types of books still fare well—including celebrity memoirs and religious titles. But in recent years, print sales in such categories as biography, current affairs and business and economics—what publishers refer to as “serious nonfiction” and which tend to resonate especially with men—have fallen considerably. Sales of nonfiction print titles were down nearly 8% through May 9 this year, and sales of books about politics and current affairs were down 19%, according to book tracker Circana BookScan. Publishing has long been subject to cyclical changes, with trends in format and genre taking over bookshelves in grand sweeps. (Remember the adult coloring-book craze? Or the stratospheric rise of romantasy?) But many in publishing believe the decline in serious nonfiction is more existential. “The trend couldn’t be clearer,” said Jonathan Karp, the former chief executive of Simon & Schuster and publisher of the new Simon Six imprint. “This is a sea change and people should wake up and realize we’re living in a new world.” One culprit for the shift: a new media diet for fans of more serious nonfiction. … Sixty-two percent of men and 54% of women consumed a podcast in the prior month, according to a recent survey by Edison Research at SSRS, up from 46% and 39%, respectively, in 2023. “When we have internal meetings to talk about this problem, it always comes around to podcasts,” said Jonathan Burnham, president and publisher of the Harper Group at HarperCollins Publishers. “The man who wants to read American history is now tuning into one of the many good podcasts about history that lends the quiet attention to a serious subject he’s looking for. It makes the idea of sitting down with a 700-page Ron Chernow book less appealing. You’ve scratched that itch.” Source: Wall Street Journal Remarkable report by Novara from the nationalist rally in London in mid May. Anna Airy, Leopard Moth and Plums, 1915 If you’ve scrolled this far, you know you want to click: Subscribe
Warhammer Skulls 2026 – All The News and Updates for XBOX
Warhammer Skulls returned today for its 10th anniversary – bringing news and updates on Warhammer games, plus discounts to be enjoyed across XBOX platforms.
House set to vote on American women’s history museum
The project enjoyed wide bipartisan support before Republicans amended it in March to ensure only females at birth could be honored.
I tried 17 Trader Joe's cheeses, ranked worst to best: Review
I tried all the Trader Joe's cheeses I could find and ranked them from worst to best. I enjoyed the creamy Toscano soaked in syrah and Bucheron.
Flower business proves "life-giving" for Lily of the Valley florist
Andrea Patten started arranging and selling bouquets as Lily of the Valley Floral just for fun. But just a few months into the venture, she’s selling bouquets at a local grocery store regularly and has done special orders for holidays and events. Patten told WTIP that she’s always enjoyed working with flowers, but never saw...
Community: Assumption High rodeo raises funds for FFA program
Rodeo fans enjoyed a weekend of fun, festivities and western entertainment at the 14th annual Assumption High School FFA Benefit Rodeo at the Assumption Parish Agriculture Complex April 24-25.
SIU holds inaugural Science Reception to recognize outstanding students and faculty
The College of Agricultural, Life, and Physical Sciences at Southern Illinois University Carbondale held its inaugural Science Reception at the Gower Translational Research Center on April 30. Around 200 attendees enjoyed the evening, which included a reception, happy hour and awards ceremony.
Medina business owner bound for France to compete in four-wheeler race
While local business owner Jessica Elioff has enjoyed four-wheelers most of her life, she didn’t start racing them until 2019. And after seven years of success competing stateside, Elioff will travel to France in August with a team of two other women to compete in the international endurance race, Pont-de-Vaux.
Local vendor speaks on Lilac Festival's business boost for their business
Rochester, N.Y. Vendors at the Lilac Festival enjoyed a business boost for the next several days.
Photos: 2026 Business 500 Reception, presented by Bayer & Science Delivers
On April 30, business leaders and honorees gathered in the Grand Hall at St. Louis Union Station for the St. Louis Business 500 Reception, presented by Bayer and Science Delivers. The evening celebrated the second edition of the Business 500 list, recognizing some of the metro area’s most influential, impactful, and innovative leaders. Guests enjoyed […]
Real Madrid contacted former legendary manager to replace Xabi Alonso
Alvaro Arbeloa was the selected candidate to replace Xabi Alonso as the head coach of Real Madrid after the Spanish Super Cup in January.However, the former youth team manager has not enjoyed the best...
Richwoods students dance the prom night away at Venue Chisca
Richwoods High School students and their dates enjoyed prom night Saturday at Venue Chisca in Peoria's Warehouse District.
Santa Fe County sheriff candidates divide on behavioral health solutions
Former police chief Paul Joye has advocated for an alternative response model in Santa Fe County; his opponents have expressed doubts.
Fine chandeliers are a specialty for New Orleans business | Home/Garden
Michael Melesurgo and Ricardo “Rico” Mencia purchased Classic Chandelier from the business’s founder, Peter Sather, in 2023, when he decided to retire. The business partners rebranded the company as Vintage Chandelier and relocated it to 455 Philip St. in the Irish Channel in December 2025.The company offers a variety of services including cleaning, moving, restoration, installation, pick-up, delivery and general maintenance of light fixtures, with a specialty in fine antique chandeliers.Additional specialties include the installation and restoration of mirrors and artwork, with pick-up and delivery included. googletag.cmd.push(function() { googletag.display('fixed-breakout-mobile-1'); }); googletag.cmd.push(function() { googletag.display('fixed-breakout-tablet-1'); }); “We mainly focus on older fixtures, but we have also worked on newer ones, especially with installation,” Melesurgo said. “We aim to be able to work on almost anything within reason. But chandeliers are the meat and potatoes of the business.” googletag.cmd.push(function() { googletag.display('fixed-sticky-rail-1'); }); googletag.cmd.push(function() { googletag.display('fixed-breakout-desktop-1'); }); The team at Vintage Chandelier has worked on some of the best-known chandeliers in New Orleans, at hotels including the Ritz-Carlton and the Hyatt Regency, the Milton H. Latter Memorial branch of the New Orleans Public Library and several prominent homes.Inside Out sat down with the duo to discuss the identification and care of fine chandeliers. googletag.cmd.push(function() { googletag.display('fixed-breakout-mobile-2'); }); googletag.cmd.push(function() { googletag.display('fixed-breakout-tablet-2'); }); What are some of the hallmarks of a fine chandelier?Melesurgo: Some of the finer points of elegant chandeliers are pristine crystal, clean craftsmanship, original pieces and parts and stamped pieces to ensure authenticity. Everything should be clean and working.How should you clean a fine chandelier?Melesurgo: The material in question determines the methodology for cleaning. Crystal chandeliers should be cleaned by hand, crystal by crystal, to ensure the best outcome, and to avoid deterioration of metal wiring typically used in connecting pieces together. Spraying cleaners can, over time, sit on the metal and end up rusting connections that compromise the connections. googletag.cmd.push(function() { googletag.display('fixed-breakout-mobile-3'); }); googletag.cmd.push(function() { googletag.display('fixed-breakout-tablet-3'); }); googletag.cmd.push(function() { googletag.display('fixed-sticky-rail-2'); }); googletag.cmd.push(function() { googletag.display('fixed-breakout-desktop-2'); }); What in your backgrounds led you to this business?Melesurgo: I have an electrical background. I started as an electrical apprentice in the local union (IBEW 130) in 2005. Then Katrina hit. I ended up going back to school and getting a degree in Hotel, Restaurant and Tourism and graduating in 2011. I started working for Peter (Sather) at Classic Chandelier & Mirror in 2012, which was supposed to only be temporary, but I ended up staying for a lot longer. I have always enjoyed working with my hands and being creative. This allows me to be creative and keep a lot of beautiful history alive. googletag.cmd.push(function() { googletag.display('fixed-breakout-mobile-4'); }); googletag.cmd.push(function() { googletag.display('fixed-breakout-tablet-4'); }); Rico, you worked as a draftsman alongside an engineer at YKM Consulting. googletag.cmd.push(function() { googletag.display('fixed-sticky-rail-3'); }); googletag.cmd.push(function() { googletag.display('fixed-breakout-desktop-3'); }); Mencia: The job was interesting, especially working on the Ochsner expansion, but staring at two monitors all day became unbearable. I went to work for Peter (Sather), which opened a new world to antiques and chandeliers that I find fascinating. Vintage Chandelier, 455 Philip St., (504) 309-8983, @vintagechandelier.504 on Instagram googletag.cmd.push(function() { googletag.display('fixed-sticky-rail-4'); });
Who was invited to dinner with King Charles: Justices, business leaders and Palm Beach friends
President Donald Trump and first lady Melania Trump hosted a white-tie dinner at the White House with King Charles III and Queen Camilla. Nearly 130 guests enjoyed Dover sole meunière and a beehive-shaped chocolate dessert on Tuesday night. The guest list included business leaders, tech CEOs and friends from Palm Beach, Florida. The six conservative justices on the Supreme Court also attended, despite Trump’s recent criticism over tariffs. Fox News stars and other conservative media figures were present, along with three of Trump’s children, his father-in-law, sports figures and lawmakers, including House and Senate leaders.
See where Kansas baseball ranks in USA TODAY Sports Coaches Poll
KU baseball enjoyed a rivalry sweep over the weekend against Kansas State. So, where does it rank in the top 25 of the USA TODAY Sports Coaches Poll?
Bounce into Summer with Party Hats Entertainment!
Evan leads Abby, Rachel, Cesar and Maurissa in an obstacle course and nerf gun fight to be enjoyed by kids and adults alike.
The Autograph Wedding Experience hosts expo at Hotel Paso del Norte
EL PASO, Texas (KVIA) -- The Autograph Wedding Experience held a wedding expo Sunday evening at Hotel Paso del Norte. The event featured fully designed wedding environments, giving attendees a chance to explore different styles and themes for their big day. Guests also enjoyed a runway show highlighting the latest in bridal fashion. In addition
Canada's Carney has enjoyed a long political honeymoon. Now comes the test
Global acclaim and domestic political gains have defined Mark Carney's first year as Canada's PM. He now faces pressure to deliver on his bold promises.
Iraq’s Communists Are Fighting Against Sectarian Politics
Although Iraq’s Communist Party has lost much of the support it enjoyed at its peak, it still has a real presence on the Iraqi political scene. Its general secretary Ra’id Fahmi tells Jacobin about the need to challenge Iraq’s sectarian power structure.
High Runner’s High: Marijuana and running in joint use across North Ashland
Running and cannabis use have several similarities. They both challenge a person’s lung capacity, they both generally result in an increased appetite, and they can both be enjoyed indoors or outside. Despite the overlap, the idea to participate in both simultaneously as a community is a relatively new concept. Chicago natives Anakaren Ramirez and Carlos...
STEM SHOWCASE AT YSU: Science concepts spawn real-world creations
YOUNGSTOWN — During her childhood, Meghan Crump enjoyed certain fast movements, though years later, her interest shifted to things that move quickly but are far smaller than her. “I was a very creative person in high school. I was a student who loved school,” Crump, a Youngstown State University senior and 2022 Austintown Fitch High […]
Prom 2026 photos. Rankin County special education students dance the night away
RCSD special education students enjoyed prom at Florence High School in Florence, MS, during Prom 2026.
Virginia Beach Oceanfront curfew raises concerns for local businesses
Visitors and locals alike enjoyed a picturesque morning at the Virginia Beach Oceanfront, hours before the temporary emergency curfew takes effect.
Kid investors are making money from the Pokémon card trading boom
Pokémon has enjoyed a resurgence in recent years, becoming the world's No. 1 toy property, but it's a long way from the game many adults remember.
Why some tech leaders are sounding the alarm about Colorado’s ‘deteriorating’ business climate
Colorado enjoyed a reputation of being business-friendly in recent decades. But some in the business community worry that too much regulation is hurting the state’s ability to attract new companies. And they’re asking the governor for help.
Chris Paul dances on Clippers' grave with meme after former team's play-in collapse vs. Warriors
Chris Paul enjoyed his former team's brutal loss on Wednesday.
Five players miss Arsenal’s training ahead of the Sporting game
Arsenal are set to face Sporting Club in the Champions League in a matter of hours, but concerns are growing over the potential absence of several key players. The Gunners have enjoyed an impressive s...
Fund science, downtown living expensive, protect America
I enjoyed reading the article about how Artemis II “captivated Americans young and old across political divides, bringing unity of wonder, hope and pride to a nation torn by partisan
How Audrey Hepburn impacted fashion, entertainment and even World War II
“The most important thing is to enjoy your life. To be happy. It’s all that matters,” Hepburn once said. If one is to follow her example, then a life of fashion, elegance, creativity, advocacy and kindness is a life to be enjoyed.
Manchester United vs Leeds – Match preview and team news
Manchester United host Leeds United on Monday night to conclude the Premier League action of the matchweek.The Red Devils have enjoyed a remarkable transformation under Michael Carrick since January. ...
China, Iran weaponized the global economy to beat the U.S. at its own game
Washington once enjoyed a near monopoly over this type of economic warfare, but now American consumers and companies are starting to feel the pain.
Another Big Night for Democrats: Tuesday’s Wisconsin and Georgia Results
Democrats enjoyed another double-digit victory in a Wisconsin state Supreme Court race; their win will expand the liberal majority on the body to 5-2. Meanwhile, Republicans held GA-14, although it made for another Democratic overperformance.
13th annual Tuck Entertainment Easter Egg Hunt brings joy - WNKY News 40 Television
FRANKLIN, Ky. – Hundreds of children and families gathered in Franklin, Kentucky for the 13th annual Easter Egg Hunt by Tuck Entertainment at Lincoln Park. Kids flooded the park and enjoyed the free family event. There were prize giveaways, free haircuts and so much more. However, the main goal was to share the reason for the season, and that’s their...
‘This is a recalibration’: Trump Cabinet worries no one is safe after Bondi and Noem firings
When President Donald Trump ousted his attorney general, Pam Bondi, it sent a clear message to his remaining Cabinet members: The job security they’ve enjoyed until now is no longer guaranteed.
LA Chargers help high school athletes learn lifesaving CPR
More than 250 high school student-athletes from across the Los Angeles Unified School District spent a day learning about heart health alongside Los Angeles Chargers players.Students learned hands-only CPR, met Chargers players Elijah Molden and RJ Mickens in UCLA Health Sports Performance Training, Powered by Exos, and enjoyed lunch on the patio at Huddle for Heart Health, held March 19 at The Bolt, the Chargers’ official practice facility in El Segundo. RJ Mickens, left, and Elijah Molden joined more than 250 LAUSD high school students at the Huddle for Heart Health event. (Photo courtesy of Joaquin Torre/Los Angeles Chargers) Along with learning CPR techniques, students practiced performance training on the LA Chargers practice field in El Segundo. (Photo courtesy of Joaquin Torre/Los Angeles Chargers) LA Chargers defensive back RJ Mickens visits with high school students at the Huddle for Heart Health event. (Photo courtesy of Joaquin Torre/Los Angeles Chargers) The event was presented by UCLA Health, the American Heart Association, the Los Angeles Chargers and LAUSD.Hands-only CPR is a lifesaving skill, said David Sato, MD, board president of the American Heart Association Los Angeles.“We save more lives when we work together,” said Dr. Sato. “This collaboration with UCLA Health and the Los Angeles Chargers to teach students how to perform hands-only CPR helps ensure more families in Los Angeles have someone ready to act in a cardiac emergency when seconds count.”Hands-only CPR is a lifesaving procedure for cardiac emergencies that doesn’t involve rescue breaths. It involves pressing hard and fast in the center of the chest of a teen or adult who has collapsed. Pressing can be done to the beat of the Bee Gee’s hit “Stayin' Alive, which, at 100 beats per minute, is the minimum rate at which to push during hands-only CPR, according to the American Heart Association. LA Chargers defensive back Elijah Molden, standing, helps high school students learn CPR skills. (Photo courtesy of Joaquin Torre/Los Angeles Chargers) Most cardiac arrests that don’t happen in the hospital happen at home, and hands-only CPR is as effective as CPR with breaths in the first minutes following a cardiac emergency.
Everything You Missed at Shop TODAY Stages 2026 Health & Wellness Summit
Guests enjoyed a day full of expert chats, pampering and, of course, plenty of free products.
Hands-on science program brings STEM to life at Mass. school
The school's 5th graders enjoyed a special science lesson by Preeti Mostello, an educator with the nonprofit Traveling Science Workshops from the Discovery Museum in Acton.
Play It Again Sports (Arkansas Sports University Inc.) - Talk Business & Politics
Cameron Campbell always enjoyed playing sports. His two favorite sports were basketball and baseball. When he got out of school, he wanted to do something where he was still involved...
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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