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Newsmakers: Colliers promotes Reilly
This week’s Newsmakers includes a Colliers promotion, a new CMC neurosurgeon, four hires at LMR and new trustees at Franklin Pierce University.
Theatrical Is Alive: YTD Domestic B.O. Surges Past $8 Billion, Two Months Sooner Than 2025
The motion picture studios can easily sing that 42nd Street song “We’re in the Money” as the U.S. and Canada box office clicked past the $8 billion mark on Friday. Why is this a big deal? Because in p...
Michael B. Jordan Wears Fear of God at CultureCon 2026
The Oscar-winning actor was honored with the Legacy in Motion award at the New York event.
Fayetteville architect appointed to Achieve Community Alliance board
Fayetteville-based Washington Regional and Dallas Real Estate Services were among companies and organizations in Northwest Arkansas to recently announce new hires, promotions and awards. NEW HIRES Healthcare Cody Jones Fayetteville...
Pat Fitzgerald Sends Emotional Message to Michigan State Fans
Pat Fitzgerald delivered an emotional message to Michigan State fans following the Spartans' fourth straight loss, asking Spartan Nation to keep believing.
Apple A20 outclasses Android rivals in our review: iPhone's lead is impressive
New iPhone 18 Pro reviewed! Our review shows what the flagship can do: a 2nm A20 Pro processor, 12 GB of RAM and a 6.3" ProMotion OLED display. Find out all about the camera upgrade (48 MP with a variable aperture), the long-lasting 4,056 mAh battery and faster 45-watt charging
Attorney returns to firm where his career began; high school's CFO hired by Archdiocese
Take a look at some of the recent promotions and new hires announced at south Louisiana businesses.
Knicks' Towns opens up about grief for World Mental Health Day
Karl-Anthony Towns shared his emotional journey following the death of his mother six years ago to mark World Mental Health Day on Saturday.
Silent Hill, Gravity Rush director's Bokeh Game Studio is reportedly casting for a new horror game
Bokeh Game Studio, from Silent Hill director Keiichiro Toyama, is reportedly casting motion capture performers for a new, untitled horror game.
According to Science, People Who Use Emojis in Texts Have Higher Emotional Intelligence
You probably do it without thinking. A thumbs-up after confirming dinner plans, a laughing face to soften a sarcastic remark, a heart slipped into a goodnight message. Emojis have become so woven into the way we text that most of us never stop to wonder what those tiny icons actually say about us. But researchers...
Stop trying to hack your feelings. Mental health takes work
After decades of studying and teaching emotional intelligence, one lesson keeps returning: We do not fix feelings. We learn how to work with them.
French astronaut recounts 'astonishing' emotions after return to Earth
French astronaut Sophie Adenot has returned back to earth full of "emotion" after spending eight months in space – breaking the record for the longest uninterrupted orbital stay by a European astronaut.…
Contest-Winning Microscope Thrown Out for Using Generative AI
Ning Xu's winning entry to Nikon Instruments' Small World in Motion competition was ineligible due to AI, a spokesperson for the contest told Gizmodo.
Winning Nikon Small World in Motion video disqualified for AI use
New winner is Nguyen Nam Nhat of Vietnam for video of a roundworm and single-celled Dileptus.
Nikon microscopic video competition winner disqualified for using generative AI
Nikon says it’s revisiting its competition rules after the original winner’s video was too good to be true.
Prize-winning image which sparked backlash was AI-generated, Nikon rules
The camera-maker says it is now re-evaluating the rules and procedures of its Small World in Motion contest.
Employee development shouldn’t stop at promotion
A promotion is only the beginning. For businesses competing to retain top talent, advancing employees into leadership roles can be a powerful investment, but a new title doesn’t automatically make someone an effective manager. As Business Report writes in its Best Places to Work issue, training, mentorship and ongoing support can help newly promoted employees […]
Zack Polanski faces greatest crisis of his leadership so far
The Green leader faces pressure over his response to a party motion declaring Zionism a form of racism, as well as his by-election loss.
Video: Opinion | How TikTok Warps Our Politics
What are the political consequences of the era of video? TikTok is overwhelming our world with emotional appeals that print media can’t capture, according to the Times of London columnist James Marriott, and it’s making us more mystical, tribal and autocratic.
Linkin Park documentary 'Unshatter' tracks band's emotional return to recording, touring
Linkin Park is revealing the uncertainty, grief and creative risk behind its return in the new documentary “Linkin Park: Unshatter.”
Linkin Park documentary 'Unshatter' tracks band's emotional return to recording, touring
Linkin Park is revealing the uncertainty, grief and creative risk behind its return in the new documentary “Linkin Park: Unshatter.” The film captures the band as it grappled with what
Linkin Park documentary 'Unshatter' tracks band's emotional return to recording, touring
Linkin Park is revealing the uncertainty, grief and creative risk behind its return in the new documentary “Linkin Park: Unshatter.” | WBBM Newsradio 780 AM & 105.9 FM
Linkin Park documentary 'Unshatter' tracks band's emotional return to recording, touring
Linkin Park is revealing the uncertainty, grief and creative risk behind its return in the new documentary “Linkin Park: Unshatter.” | KCBS All News 106.9FM and 740AM
Linkin Park documentary 'Unshatter' tracks band's emotional return to recording, touring
Linkin Park is revealing the uncertainty, grief and creative risk behind its return in the new documentary “Linkin Park: Unshatter.” | KMBZ
Linkin Park documentary 'Unshatter' tracks band's emotional return to recording, touring
Linkin Park is revealing the uncertainty, grief and creative risk behind its return in the new documentary “Linkin Park: Unshatter.” | WWL
Memphis People in Business for Oct. 8, 2026
A look at promotions, hirings, movers and newsmakers in the Memphis area business scene
Desmond Bane Gets Emotional About First Return to Memphis
Desmond Bane said returning to Memphis as an opponent made him nervous as he reflected on what the city and Grizzlies still mean to him.
PhoneBot gives old smartphones a new job on two legs
Smartphones combine cameras, motion sensors and powerful processors in devices that fit inside a pocket. These features could also make them useful components for robots, reducing the need to buy and ...
Whitesides Cosponsors Motion Picture, Television, Entertainment Act
Rep. George Whitesides (CA-27) hzs announced his cosponsorship of the bipartisan, bicameral Motion Picture, Television and Entertainment Revitalization Act
Heart Attack Recovery Isn't Just Physical. Your Mental Health Matters, too
A heart attack or heart disease diagnosis can affect more than a person's physical health. Depression, anxiety and other emotional challenges are common following a cardiac event, making mental health an important part of the recovery process. In recognition of National Depression Screening Day, Dr. Amar Doshi discusses the connection between heart health and emotional well-being, explains why psychological distress is common after a cardiac event and shares strategies to support both mental and physical recovery.
Getting health advice online? A study suggests you may be getting a sales pitch
Pew Research Center found 38% of health influencer posts promoted products, services or subscriptions, with promotions appearing in about two-thirds of posts about supplements and over-the-counter medications.
Jingjing Liu
Jingjing Liu’s promotion expands upon his previous responsibilities as vice president and corporate secretary of Henniges Automotive.
We have to take emotion out of Saints derby
Pompey midfielder Ebou Adams says there is a fine line between becoming the hero or the villain against Southampton.
"What's the point of this if you're not feeling something?" Star Wars: Galactic Racer devs share the secret to bottling the incredible game feel of Burnout
The Star Wars: Galactic Racer developers at Fuse Games talk board games, emotions, and looking up "verisimilitude".
New iPad Mini Rumored to Have 60Hz OLED Display Ahead of Launch
Ahead of the expected imminent launch of the new iPad mini 8, word out of Asia suggests that the device will feature a 60Hz OLED display rather than a ProMotion 120Hz display. The information comes courtesy of a hit-and-miss tipster running the account "yeux1122" on the Korean Naver blog. "There have been mentions of 120Hz in some overseas reports, but the domestic production quantity has already been confirmed to be LTPS at 60Hz," the tipster wrote. "That's it".
Entertainment
Playhouse at McConnellstown is seeking Huntingdon County food and beverage establishments to partner in its 2026 “Toast the Show: Themed Libations and Local Bites” promotion, which invites local businesses to
The New York Times
Chris Gallant, a Democrat running to represent Long Island, was revealed last month to have appeared in revealing promotional photos for a fetish brand. He has leaned in with the slogan “Make...
Boston Scientific promotes Fitzgerald to COO, reorganizes business segments
Alongside Fitzgerald’s promotion, Boston Scientific will establish three reportable business segments.
PlayStation Store Sale “Player’s Choice” Live on October 7
Sony has a new PlayStation Store sale live now, and it's called the "Player's Choice" promotion. In total it has 4955 items included, though this includes a game's different editions,…
Cam Heyward defends Steelers sideline yelling in Browns loss
Cameron Heyward addresses heated arguments during Pittsburgh's loss to Cleveland, explaining why emotional exchanges are vital for accountability.
Ciara Miller fights back tears when reacting to ‘DWTS’ elimination: ‘Just sad’
Ciara Miller couldn’t help but feel all the emotions when speaking out about her ‘Dancing With the Stars’ elimination for the first time.
Toby Emmerich Joins FilmNation Entertainment's Infrared As Consultant
Former Warner Bros Motion Picture Chief Toby Emmerich is boarding FilmNation Entertainment's Infrared as a consultant.
What Do Health and Wellness Influencers Post About?
Just over half of health and wellness content on social media focuses on healthy living, while about a third discusses medical topics. And 38% of posts have a product or service promotion.
Kakao Entertainment strikes K-pop partnership with Warner’s Atlantic Music Group to develop artists ‘from the
The two companies will work together on global strategy, music production, distribution, marketing, and promotion for K-pop artists.
Can a robot become a real companion? Science is testing the limits
A robot does not need to feel emotions for a person to become emotionally attached to it. That is one of the clearest lessons emerging from research on social robots. People can name them, talk to the...
$496,892 grant to expand student well-being initiatives
St. Bonaventure University has been awarded a grant to strengthen mental health promotion, substance use prevention and pathways to care for students.
‘Crystal Ball’ – Sports Media Analyst Predicts Fox Will Lose Greg Olsen, Prompting a Drew Brees Promotion and ESPN Star Getting Poached
With the NFL season well underway, it appears the broadcasting world could see a couple of shakeups. With Tony Romo’s exit from CBS, attention is also turning to other player-turned analysts, including Greg Olsen’s situation at Fox, which is expected to create a ripple effect in sports broadcasting.
I need advice on being a better Tampa Bay sports fan
New quarterback, same problems as Bucs lose to Packers to fall to 0-4 | Oct. 5 Trying to be betterDear Tampa Bay fans, I need advice from people who understand the joy and occasional emotional damage of Tampa Bay sports.
Lionel Messi ends Argentina career with goal and two assists against Benin on emotional night
Lionel Messi finishes his international career with 208 senior caps, the most of any player in the teams history, with his 126 goals for Argentina also a record; On an emotional night against Benin, Messi also created the first two goals, before getting on the scoresheet himself
🥐 Unstoppable Spain, farewell to Leo: Wednesday’s 5️⃣ stories
The football action on October 7 brought qualification for Spain's senior and Under-21 teams, Leo Messi's emotional farewell to Argentina, controversy surrounding Cristiano Ronaldo, and the battle for...
Kakao Entertainment partners with Atlantic Music Group to expand K-pop globally
The companies will collaborate on global strategy, production, distribution and promotion for K-pop artists.
REP LIEU JOINS REP. FRIEDMAN, LOS ANGELES DELEGATION, AND ENTERTAINMENT UNION IN PUSH FOR NATIONAL FILM TAX CREDIT
GLENDALE, CA – Today, October 6, 2026, Congressman Ted Lieu (D-Los Angeles County) joined U.S. Congresswoman Laura Friedman (D-Los Angeles County), Members of the Los Angeles congressional delegation, and the major unions representing film and television workers at the Alex Theatre in a new push for the Motion Picture, Television, and Entertainment Revitalization Act.
Trump Does Not Plan to Reimburse Taxpayers for Promotional Ads
A day after the president said his super PAC would pay for the ads, which had drawn bipartisan backlash, officials said that he meant moving forward. A new taxpayer-funded ad aired Tuesday.
First minister to face no-confidence vote over Drumcree row
The motion comes amid a major political row over a planned Orange Order march in Portadown.
Lee Health Announces Executive Leadership Promotions - Florida Hospital News and Healthcare Report
Oct. 6, 2026 — Lee Health is proud to announce several executive leadership promotions that will help guide the health system as it continues to expand access to high-quality care […]
😭 Farewell Leo: the emotional video bidding Messi goodbye
Today, Leo Messi will bid his grand farewell to the Argentina national team at the Monumental stadium against Benin.With the occasion bringing Argentina to a standstill, the AFA has shared a video tha...
NASA’s Webb Captures Commotion From Nebula’s Stellar Jets
A cauldron of cosmic creation is being revealed in a new image from NASA’s James Webb Space Telescope. Webb has unveiled numerous stars formerly hidden by
Holy Cross Health Offers $100 Mammograms During Breast Cancer Awareness Month - Florida Hospital News and Healthcare Report
Uninsured patients qualify for the promotional rate, available from October 1 to 31. October 5, 2026 – During Breast Cancer Awareness Month, Holy Cross Health is offering screening mammograms and […]
Caitlin Clark sends emotional message after missing Fever exit interviews
Caitlin Clark wasn’t with the Fever for Saturday’s exit interviews, but there was a meaningful reason behind her absence.
DITP Promotes Thailand's Entertainment Industry on the Global Stage with "Thai Night Busan 2026& ...
BUSAN, SOUTH KOREA - Media OutReach Newswire - 6 October 2026 - The Department of International Trade Promotion (DITP), Ministry of Commerce, has announced its readiness to bring Thai companies in the film and content industry to the Asian Contents & Film Market (ACFM) 2026, a major marketplace
Trump says he will stop using taxpayer funds for self-promoting ads after backlash
President claims commercials were ‘positive promotion for our Great USA’ but says he will now cover their cost
Countries race to provide oral health care for all in 100-Day Sprint across Asia
Twenty Asian countries and areas across the WHO Western Pacific and South-East Asia regions vowed to strengthen essential oral health benefits as part of a “100-Day Sprint” initiative, during the 16th Asian Chief Dental Officers Meeting held from 27 to 29 September in Kota Kinabalu, Malaysia. The meeting marked the midpoint of the 100-day sprint bolstering support for countries to develop essential oral health benefit packages that can be integrated into national universal health coverage plans. Convened by the two WHO regional offices and the Malaysian Ministry of Health as the Secretariat, the meeting brought together national oral health leaders from 20 Asian countries, staff from all levels of WHO, WHO collaborating centres and other development partners. Participating countries and areas included: Bangladesh, Bhutan, Brunei Darussalam, Cambodia, China, Hong Kong (SAR) China, India, Indonesia, Japan, Lao People’s Democratic Republic, Malaysia, Maldives, Mongolia, Nepal, the Philippines, Singapore, Sri Lanka, Thailand, Timor-Leste and Viet Nam. Participants reviewed progress and refined proposals using the WHO Service Package Delivery and Implementation (SPDI) Platform. Countries conducted bottleneck analyses across four key areas: service delivery, workforce, access to essential medicines and health products, and health financing. They identified practical actions to address implementation challenges and refined proposed revisions to their national oral health benefit packages. “There is no health without oral health. Through the 100-Day Sprint, countries are advancing the implementation of the Western Pacific regional implementation plan on oral health and strengthening progress towards universal health coverage,” noted WHO Regional Director for the Western Pacific Dr Saia Ma'u Piukala. Participants identified bottlenecks and proposed workable solutions to strengthen access to essential oral health care through primary health care, sharing experiences and discussing how best to translate policy commitments into feasible and sustainable action at the country level. Malaysian Minister of Health Datuk Seri Dr Dzulkefly Ahmad highlighted the importance of prevention and primary health-care approaches to improve oral health: “Oral diseases can have lifelong consequences, yet many are preventable. By integrating essential oral health care into primary health care and promoting prevention in schools and communities, we can improve oral health across the life course.”The WHO team led by Dr Huong Tran, Director of the Division of Health Promotion, Disease Prevention and Control of the WHO Western Pacific Region and national oral health leads from over 20 Asian countries visited the SK Pekan Putatan School, Sabah for school oral health programme including flouride mouth rinsing. © WHO / V. ChaudharyDr Huong Tran, Director of the Division of Health Promotion, Disease Prevention and Control for the WHO Western Pacific Region, emphasized key collaborative roles WHO can play. “Oral diseases are the most common noncommunicable diseases, yet many can be prevented and treated through essential oral health services delivered at the primary health-care level,” she said. “By sharing experiences and using WHO tools such as the SPDI Platform, countries are accelerating progress towards universal health coverage for oral health.” “Integrating oral health into broader health services is essential for reducing inequities, expanding access and recognizing oral health as an integral component of overall health and well-being. The 100-Day Sprint provides an important opportunity to translate this commitment into practical action and ensure that quality oral health services reach all people, especially those most in need,” said Dr Suman Rijal, Director of the WHO South-East Asia regional Department of Healthier Populations and Noncommunicable Diseases. As host of the meeting, Malaysia showcased ongoing efforts to strengthen oral health care through primary health care and prevention-focused approaches, while providing a platform for countries across the two WHO regions to exchange experiences and accelerate progress towards universal health coverage for oral health. “WHO is encouraged by Malaysia's leadership in addressing the burden of oral diseases and advancing universal health coverage for oral health through practical, country-led action,” said Dr Rabi Abeyasinghe, WHO Representative to Malaysia, Brunei Darussalam and Singapore. Countries will continue to refine and figure costs for national oral health benefits during the remaining sessions of the 100 days. These efforts support implementation of the WHO Global strategy and action plan on oral health 2023–2030, while also helping to expand access to essential oral health services through stronger and more equitable health systems across the WHO Western Pacific and South-East Asia regions.______________For more information, or to arrange media interviews, contact: WHO Regional Office for the Western Pacific: wprocom@who.int WHO Regional Office for South-East Asia: SEMediaRelations@who.int
Trump says he will pay for campaign-style ads himself after backlash over taxpayer-funded effort
President Donald Trump said Monday he will no longer use taxpayer money to fund a series of promotional television ads, announcing that he will instead pay for them with funds raised for MAGA, Inc., the pro-Trump super PAC.
Japan's entertainment robots diversify with AI, offer comfort
The range of home entertainment robots is becoming increasingly diverse in Japan, with some providing emotional comfort like pets, and others serving as fashion accessories due to their cute appearance. The growing use of artificial intelligence is also helping to expand the market, widely seen as having taken off with…
Green party of England and Wales facing ostracism over ‘Zionism is racism’ vote
European Green party says motion goes against its policy, with German Green co-leader calling it ‘intolerable and unacceptable’
iPhone 13 Pro vs. iPhone 18 Pro Buyer's Guide: Is It Worth Upgrading?
Apple released the iPhone 18 Pro and iPhone 18 Pro Max in September 2026, five years after the iPhone 13 Pro and iPhone 13 Pro Max. The 2021 models introduced ProMotion displays, macro photography, a 3x Telephoto camera, and substantially longer battery life than their predecessors. They remain capable phones and support iOS 27, but owners now have five generations of upgrades to consider.
Behind the Seams | Wildwood
Go behind the scenes at LAIKA Studios for an up-close look at the extraordinary costumes of ‘Wildwood,’ the studio’s most intricately designed stop-motion film yet. Nearly 20 years after ‘Coraline,’ LAIKA’s artists and designers reveal how every tiny stitch, button and layer of fabric is handcrafted and engineered to help bring its puppets to life, combining costume design, fabrication and animation at an astonishing scale.
Stephen King and Peter Straub’s Other Worlds Than These Will Break Your Heart
‘The Talisman’ finale is an emotional adventure story, resurrecting old friends, forgotten memories, and vanished worlds.
Patrick Mahomes shares an emotional message for an injured teammate
During his press conference, Kansas City Chiefs quarterback Patrick Mahomes shared an emotional message for injured WR Tyquan Thornton | @EdEastonJr
Scientists uncover recurrent patterns within chaotic quantum behavior
Many complex quantum systems rapidly lose the recognizable patterns of their initial states as their components interact. To describe patterns of regular and chaotic motion in specific systems, physicists ...
Jagex responds to use of generative AI in RuneScape trailer made by "trusted external partner"
Developer removes promotional material as it investigates situation, says it highlights "an issue with our own processes which we must address"
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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Countries race to provide oral health care for all in 100-Day Sprint across Asia
Twenty Asian countries and areas across the WHO Western Pacific and South-East Asia regions vowed to strengthen essential oral health benefits as part of a “100-Day Sprint” initiative, during the 16th Asian Chief Dental Officers Meeting held from 27 to 29 September in Kota Kinabalu, Malaysia. The meeting marked the midpoint of the 100-day sprint bolstering support for countries to develop essential oral health benefit packages that can be integrated into national universal health coverage plans. Convened by the two WHO regional offices and the Malaysian Ministry of Health as the Secretariat, the meeting brought together national oral health leaders from 20 Asian countries, staff from all levels of WHO, WHO collaborating centres and other development partners. Participating countries and areas included: Bangladesh, Bhutan, Brunei Darussalam, Cambodia, China, Hong Kong (SAR) China, India, Indonesia, Japan, Lao People’s Democratic Republic, Malaysia, Maldives, Mongolia, Nepal, the Philippines, Singapore, Sri Lanka, Thailand, Timor-Leste and Viet Nam. Participants reviewed progress and refined proposals using the WHO Service Package Delivery and Implementation (SPDI) Platform. Countries conducted bottleneck analyses across four key areas: service delivery, workforce, access to essential medicines and health products, and health financing. They identified practical actions to address implementation challenges and refined proposed revisions to their national oral health benefit packages. “There is no health without oral health. Through the 100-Day Sprint, countries are advancing the implementation of the Western Pacific regional implementation plan on oral health and strengthening progress towards universal health coverage,” noted WHO Regional Director for the Western Pacific Dr Saia Ma'u Piukala. Participants identified bottlenecks and proposed workable solutions to strengthen access to essential oral health care through primary health care, sharing experiences and discussing how best to translate policy commitments into feasible and sustainable action at the country level. Malaysian Minister of Health Datuk Seri Dr Dzulkefly Ahmad highlighted the importance of prevention and primary health-care approaches to improve oral health: “Oral diseases can have lifelong consequences, yet many are preventable. By integrating essential oral health care into primary health care and promoting prevention in schools and communities, we can improve oral health across the life course.”The WHO team led by Dr Huong Tran, Director of the Division of Health Promotion, Disease Prevention and Control of the WHO Western Pacific Region and national oral health leads from over 20 Asian countries visited the SK Pekan Putatan School, Sabah for school oral health programme including flouride mouth rinsing. © WHO / V. ChaudharyDr Huong Tran, Director of the Division of Health Promotion, Disease Prevention and Control for the WHO Western Pacific Region, emphasized key collaborative roles WHO can play. “Oral diseases are the most common noncommunicable diseases, yet many can be prevented and treated through essential oral health services delivered at the primary health-care level,” she said. “By sharing experiences and using WHO tools such as the SPDI Platform, countries are accelerating progress towards universal health coverage for oral health.” “Integrating oral health into broader health services is essential for reducing inequities, expanding access and recognizing oral health as an integral component of overall health and well-being. The 100-Day Sprint provides an important opportunity to translate this commitment into practical action and ensure that quality oral health services reach all people, especially those most in need,” said Dr Suman Rijal, Director of the WHO South-East Asia regional Department of Healthier Populations and Noncommunicable Diseases. As host of the meeting, Malaysia showcased ongoing efforts to strengthen oral health care through primary health care and prevention-focused approaches, while providing a platform for countries across the two WHO regions to exchange experiences and accelerate progress towards universal health coverage for oral health. “WHO is encouraged by Malaysia's leadership in addressing the burden of oral diseases and advancing universal health coverage for oral health through practical, country-led action,” said Dr Rabi Abeyasinghe, WHO Representative to Malaysia, Brunei Darussalam and Singapore. Countries will continue to refine and figure costs for national oral health benefits during the remaining sessions of the 100 days. These efforts support implementation of the WHO Global strategy and action plan on oral health 2023–2030, while also helping to expand access to essential oral health services through stronger and more equitable health systems across the WHO Western Pacific and South-East Asia regions.______________For more information, or to arrange media interviews, contact: WHO Regional Office for the Western Pacific: wprocom@who.int WHO Regional Office for South-East Asia: SEMediaRelations@who.int
Asked Jalen Duren what his main emotion is: "I would …
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