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If Not AOC, Then Who?

What do we do if Alexandria Ocasio-Cortez decides not to run for president in 2028? It makes sense that many leftists are currently focused on calling on her to take the plunge. But the absence of a Plan B, or even much discussion about one, is worrisome. The US Left can’t afford to sit out the 2028 Democratic primary. Doing so in 2024 was a disaster: our abstention self-marginalized anti-billionaire politics from the national conversation and thereby gave space for Harris to pivot to the “center” (i.e. the policy preferences of corporate donors, establishment hacks, and AIPAC). Abstaining again in 2028 would be especially counterproductive since democratic socialists now have so much wind in our sails after our big electoral wins in NYC and across the country. It’s time to deepen our momentum, organization, and profile — not to retreat to the margins during America’s single most important political battle. Even more urgently, keeping Trump’s heir out of the White House may depend on whether leftists and the party’s unprecedentedly disenchanted base can force the Democrats in 2028 to take meaningful steps towards a very angry electorate and away from the corporate-consultant blob that has helped get us into this mess. If AOC (or Abdul El-Sayed) decides to run, we should enthusiastically go all in — DSA, fighting unions, progressive organizations, anybody who wants to see a better country and world. But, as far as I can tell from the outside, there’s a real chance that she doesn’t run. And we can’t just wait and see where she lands before discussing alternatives, since AOC’s decision might not come for quite a while, giving us little time to scramble at the last minute for an alternative. So we should start working now on getting a Plan B into motion, and recruiting a good candidate for the role. Here’s one idea. A Worker Candidate — Healthcare Not Warfare 2028 Run a union worker Leftists don’t need to always run experienced, well-known socialist politicians for high-profile contests. Lula, the current president of Brazil, began his political career as a metalworker militant who ran for governor of São Paulo in 1982. Especially in an era of institutional distrust, it’s possible to lean hard into making a virtue out of a working-class comrade’s distance from traditional politics. Experience abroad shows this clearly. Rachel Kéké — an immigrant hotel housekeeper — ran as the candidate of the leftist La France Insoumise for the National Assembly in 2022, defeating a former minister in the Macron government. The Belgian Workers’ Party in 2024 won its first Flemish seat in the European Parliament by running Rudi Kennes, a three-decade veteran of the Opel Antwerp auto factory. And the South Korean left in 2024 elected auto factory militant Yoon Jong-oh to the National Assembly. If a tiny French Trotskyist organization could make such a big splash in 2002 and 2007 by running a well-spoken postal worker cadre for office — the LCR’s Olivier Besancenot received about 1.5 million first-round votes — it’s not far-fetched to expect that a much larger organization like DSA, together with a broader coalition of the willing, could run this playbook to much greater effect. This is especially the case now that almost everything DSA does immediately becomes a national news story. We don’t need someone famous. We just need a charismatic, well-vetted comrade who works in a relatable working-class occupation — e.g. a nurse, or a worker in auto or construction, or at Amazon. Ideally, they have a compelling personal story or have been part of a significant strike or organizing campaign, but even those criteria don’t necessarily have to be deal-breakers. The main lesson of the Graham Platner fiasco isn’t that we should never run outsiders for office (the momentum he generated proves the exact opposite), but that they need proper vetting and roots in democratic membership organizations like DSA or a union. In any case, there are plenty of ways to signal working-class authenticity without resorting to Platner’s or Fetterman’s performative macho white dude affect. Better to have someone of any gender or race who is actually working class, with firm socialist politics, who can speak from experience about the day-to-day realities of trying to make it in America. There are surely at least a dozen such worker leaders in our movement nationwide; we just need to sit down and convince one that their personal sacrifice for the greater good (i.e. running for president) will be worth it. If we don’t have a frontrunner with a clear path to victory like AOC (or El-Sayed, were he to win Michigan), it’s better to embrace someone whose decision to run in itself tells an important story about US politics: workers have been iced out of our political system and are now fighting hard to break back in. The novelty factor, in itself, would generate press. And it would help democratic socialists signal to the American public that our movement’s defining characteristic is that we represent workers vs. bosses, not that we’re “the furthest left” force in American politics — a framework that suggests we’re extremists and that helps our opponents isolate us from non-college-educated voters by highlighting extremely minoritarian (and misguided) stances included in DSA’s platform like prison abolition. We don’t get many opportunities to speak to tens of millions of Americans; we need to use these opportunities to broaden our appeal beyond those already in our orbit. Run to polarize the 2028 primary and general election around “Medicare for All” and “End All Aid to Israel” Why should democratic socialists use our scarce time and volunteer energy to run in a race we’re unlikely to win? Running in the 2028 primary will not only recruit us scores of members (imagine having a DSA member intervening in eleven nationally televised primary debates!), but — more importantly — it has the potential to be a decisive leap forward towards an America that finally starts meeting the needs of working people instead of HMO and AIPAC billionaire donors. Polarizing litmus tests are good, actually — as long as they’re fought for around popular demands in a thoughtful and strategic way. Democratic socialists have an opportunity and responsibility to make the 2028 primary about two of the most widely and deeply felt issues of our moment: domestically, America’s unaffordable, family-breaking private healthcare system; internationally, America’s bankrolling of the genocidal Israeli government. A candidacy relentlessly demanding Medicare for All and No Aid to Israel would pose a sharp question to the American public, the Democratic Party, and other 2028 contenders: Why can’t working-class Americans afford their healthcare bills at the same time that our government is spending at least $3.8 billion yearly to fund an Israeli regime eager to keep dragging us and the world into more forever wars? Our candidate can agitate around a clear message: I’m running to give voice to all those working-class Americans who are struggling to get by. No matter what state you live in, who you voted for in 2024, or your background, it’s just plain common sense that we should make healthcare more affordable instead of spending billions to enable the Israeli government’s crimes against humanity. Every American who agrees with me when I say ‘Medicare for All — Not a Dime for Israel’ should make their voice heard through our campaign. Racking up a high number of votes for this agenda is a crucial way to show the Democratic Party and the country as a whole that we can’t keep supporting a life-destroying status quo in our healthcare system and in the Middle East. If we want to defeat Trump’s handpicked crony this coming November, we need to speak to ordinary people’s frustrations with the status quo — we can’t keep running the same tired establishment playbook and expecting a different result. For those highly engaged voters (or skeptical media pundits) who raise concerns about wasting votes, the candidate can take the time to explain why this isn’t the case: It's true I'm a long shot. But Zohran showed anything can happen — and voting for me is a pragmatic decision, not a wasted vote. In a heavily divided primary with a large number of candidates and a very discredited establishment, my campaign and the democratic socialist movement I’m part of are positioned to be the balance of power if we can get a large enough number of voters to loudly demand Healthcare Not Warfare. Since there’s a high chance no candidate will get to 50% in the 2028 primaries, the Democrats could very well be heading towards a brokered convention, where a disciplined, principled current committed to breaking from corporate donors can play an outsized role in making sure whoever ends up with the nomination raises the banner of single-payer healthcare and cutting aid to Israel. How exactly could running this sort of primary campaign be translated into actual leverage? The candidate replies: I’m aiming to win the nomination, but if I don’t achieve that goal, my delegates and I will pledge our support in the primary only for a candidate who agrees in the general election to call for ending US aid to Israel and establishing Medicare for All at home. These are both winning planks for November against the Republicans, and the only reason I can see that other candidates haven’t yet raised these is that they’re still more scared of the donor class than they are of the people. That needs to change. If Democratic leaders want young people, workers, and those sick of the status quo to show up in big numbers this November, they need to meet us halfway. In this way, whether or not we win the nomination, democratic socialists could still play a decisive role in 2028. The approach outlined here is similar to what radical left parties periodically do in parliamentary democracies like Denmark or Sweden when they find themselves as a junior partner electorally: they dictate to center-left allies what their terms would be for enabling, from the outside, the formation of a new government. Running a Healthcare Not Warfare candidate will make it significantly more likely that the 2028 Democratic candidate stands with ordinary people instead of donors on these two pivotal planks — a shift that will, in turn, make it easier to achieve the existentially important task of defeating MAGA’s heir in November. Look at how much popular traction the Uncommitted movement got with a similar strategy in 2024 with so little on-the-ground organization — surely we can go much further with a working-class candidate, a much bigger DSA, and a Democratic Party base that has turned against Israel, billionaires, and the hacks in the party who prop them up. Objections and Responses There are quite a few objections to this proposal, many of which are very reasonable. Let me briefly address each here. Socialists shouldn’t waste their scarce time and resources on a candidate unlikely to win. This is a good rule in general, but there are important exceptions, and presidential elections are the main one. There’s no other political contest that gets anything like this level of attention and engagement in the US, so if you want to be a serious force in nationwide politics, you basically can’t afford not to have a candidate. Far from being an overall drain on our resources, running a dynamic 2028 campaign would likely result in a major net increase in members and capacity. In that spirit, the very pragmatic Milwaukee sewer socialists — who mostly ran to win at home in Wisconsin — supported Eugene Debs’s propagandistic presidential campaigns, which they correctly saw as a crucial means of recruiting to the Socialist Party. And now that the (post-1972) Democratic Party gives more weight to voters than party operatives in determining its presidential nomination, it’s become feasible to run as a socialist in primaries without risking a split in the vote against the Republicans in November. We should just support Ro Khanna, who also supports M4A and ending aid to Israel. I like Ro Khanna and would enthusiastically vote and canvass for him for president were he to get the nomination. But there’s a real chance that Khanna’s bid for office doesn’t catch on; he lacks the grassroots organizational apparatus of DSA, and, because he’s not really of the Left or labor (despite his current very good positions), he’s unlikely to generate the type of buy-in and enthusiasm that a DSA candidate would. Moreover, Khanna would be running as an individual, not as someone emerging from and building an organized movement — his campaign would not likely focus on building sustained power from below, nor would it likely polarize the 2028 primary around M4A and Israel aid. Also, and not inconsequentially, the poor electoral results for Tom Steyer and Saikat Chakrabarti this spring suggest that there’s perhaps not much of a popular appetite in the Democrats’ base to support multi-millionaire class traitors. Much better, then, to run a democratic socialist worker. If by Super Tuesday it’s clear that our campaign has captured the main left lane in the primary, Khanna should drop out and endorse us; conversely, if he’s managed to capture this lane, DSA could at that point transform its Healthcare Not Warfare campaign into an independent campaign to elect Ro Khanna focused on winning (and holding him accountable to) those two critical planks. An openness to consolidating an anti-corporate candidate by Super Tuesday is a necessary component of the strategy I’m proposing, because otherwise we risk splitting the primary votes (per DNC rules, you need at least 15% to get any delegates to convention). We should convince Shawn Fain or Sara Nelson to run for president instead. I agree it’d be great if either ran for president, but my impression is that there’s basically no chance that will happen in 2028, because both are firmly focused on their union leadership duties (and, in the case of Fain, beating back a federal witch-hunt). This plan could have DSA end up endorsing a non-socialist, non-DSAer for president. That’s against our principles. It’s a myth, and bad politics, that socialists can’t ever support candidates who aren’t members of their organization and/or who don’t call themselves socialists. Bernie, after all, was not a DSAer. And socialists abroad regularly make tactical decisions about if and when supporting a non-socialist candidate makes sense from the standpoint of promoting working-class interests, defending democracy, and building a socialist current in the process. If your “principles” prevent you and DSA from helping achieve the momentous stride forward of having a Democratic candidate in 2028 run on Medicare for All and ending aid to Israel, those “principles” are not very good. In fact, they actively undermine the causes they’re aiming to support. We shouldn’t confuse principles (working-class independence) with tactics (the best way to advance this in a given context). In my recent article in Catalyst on Milwaukee sewer socialism (I’ve uploaded the full text here), I have a section showing how similarly rigid rules about endorsements had to be eventually discarded in the old Socialist Party nationwide after WWI because they tended to lead socialists towards a sectarian abstention from broader anti-corporate electoral insurgencies beyond their party’s control. For what it’s worth, Lenin’s current under Tsarism frequently backed bourgeois candidates in the second round of elections and Lenin himself advocated that British Communists support Labour Party candidates; for his part, Kautsky in 1912 defended the German Social Democracy’s electoral pact with the Progressives in the runoffs. If our predecessors could be that tactically flexible in an era before the limits of their underlying strategic assumptions about intransigent class politics in capitalist democracies were made clear, then there’s no need to insist on being more tactically rigid today, after a century’s worth of accumulated experience. As long as you maintain your own political profile and organization while engaging in broader coalitional efforts, there’s zero inherent contradiction with the principle of political independence. More specifically: DSA and allied organizations should enthusiastically back Michigan’s Abdul El-Sayed if AOC declines to run and he throws his hat in the presidential ring. (I have no idea whether he’s even considering this path, but there’ll surely be chatter about it if he wins his Senate race this November.) Though he doesn’t call himself a socialist, El-Sayed is a principled Berniecrat, a consistent fighter for Palestine, and would have a clear path to victory. Using the “s” word is far less important than whether a campaign fights for the interests of working people at home and abroad — and whether actively participating in it can grow the organized working class and the Left. And the same holds true if a less anti-corporate candidate were, under pressure, to adopt our two Healthcare Not Warfare planks. Why focus only on M4A and ending US aid to Israel? There are so many other important issues to fight for! Obviously there are many pivotal issues beyond healthcare and Israel, and our candidate — and especially our organizations involved in the campaign — should be prepared to speak on all of these. But one of the crucial lessons of the Zohran campaign is that you have to relentlessly stay on message if you want to cut through the noise. CNN and Fox News will want to talk about DSA’s views on Venezuela and abolishing the police; we need to polarize the debate on the widely and deeply felt issues that are most favorable for growing the Left, isolating our opponents, and winning urgently needed changes. One recent poll found 63% of Americans support M4A, even after respondents were told it would raise taxes and eliminate most private insurance. Another found that 74% of Democrats opposed “providing additional economic and military support to Israel.” And focusing on two demands sets the campaign up to be able to leverage its mandate to make clear demands upon other candidates (which we can’t do if we run with a laundry list of demands). Talking about a Plan B is a distraction from the more urgent work of building a groundswell of calls on AOC to run. It’s good for DSAers, fightback unionists, and progressive organizations to try to convince AOC to run. This proposal is meant as an addendum to pushes to get AOC to run and to line DSA up for that eventuality, not as a substitute for those efforts. But I’m worried that, like in 2024, we might eventually find ourselves with no time to find a viable alternative unless we start now. DSA, with its abundant deliberative processes, moves slowly. The approach you’re suggesting seems risky. If a DSA candidate runs but doesn’t receive a lot of votes, it’ll undercut our current national momentum. This is a reasonable worry. All big initiatives always carry risks, and the path I’m advocating is certainly not free of these. That said, if a Healthcare Not Warfare campaign doesn’t catch on like we envisioned, it’s a pretty simple pivot in March 2028 to explain that in the future we really need our standard-bearers like AOC, or our growing bench of national electeds, to step up in presidential primaries. Moreover, it’s worth noting that the risk of my Plan B proposal is on the whole significantly less than the risk entailed by an AOC run. We should all back her if she runs, since she’d fire up the base, provide huge openings for organizing, have a real shot at defeating a Republican (especially given MAGA’s unpopularity), be a great standard-bearer for our issues, particularly M4A and ending aid to Israel, and be less willing than mainstream candidates to capitulate to any anti-democratic machinations from Trump and co. But it’s also true that AOC could lose, which would be a devastating setback to the country and the Left. Or she could win and find herself unable to pass much, if any, of her (and our) program, a demoralizing prospect. So if we’re willing to take these risks with AOC (and we should), it follows that we should be able to take lower-level risks if she doesn’t throw her hat in the ring. What’s Your Plan B? The US Left is facing its biggest opening for growth and influence since the 1930s. Initiatives that would have been impossible a few months ago are now potentially feasible. A President AOC is now easier to imagine, but if she ultimately assesses that the risks aren’t worth the potential reward in 2028, we can’t be left flat-footed. So even if you’re not convinced by the specifics of my Plan B, I hope you can at least agree that it’d be a disaster for us not to have one — and not to start getting a Plan B into motion. Hopefully other organizers and political currents will put forward their responses and alternative ideas ASAP. The stakes are too high to just wait and see. More As always, please share this article widely. This newsletter depends on all you lovely people to get the word out. Thank you! I uploaded the full text of my Catalyst article on Milwaukee sewer socialism here (it’s updated and 3x as long as the version published earlier on this substack). If you haven’t yet, please make sure to subscribe to Catalyst here; I read every issue front to back, highly recommend. 🌹🎵 Ivan Lins (arranged by Arthur Verocai) — “General da Banda” 🌹🎵

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May 31 • 10:39 AM EDT • Technology • thenextweb.com

108 top economists predicted 'devastation' — Argentina's Milei continues to prove them wrong

Three years into Milei's presidency, Argentina's economy has been transformed. Economists who predicted failure now see a playbook other nations could follow.

May 31 • 9:59 AM EDT • Business • foxbusiness.com

Space Force’s commercial gatekeeper offers a playbook for startups seeking defense business

Space Force’s commercial gatekeeper offers a playbook for startups seeking defense business Space Force’s commercial gatekeeper offers a playbook for startups seeking defense business

May 29 • 10:53 AM EDT • Business • spacenews.com

This year’s World Cup is testing the public health playbook

Although rare diseases like Ebola are concerning, experts say that most public health preparation for the World Cup has been focused on familiar issues – but ramped up to match the scale of the event.

May 27 • 6:00 AM EDT • Health • cnn.com

His Business Was Burning Cash and Nearly Closed in the First 6 Months — Here's the Counterintuitive Strategy That Turned Everything Around

His restaurant almost didn't make it. Now he's passing down the playbook that turned it around.

May 26 • 1:30 PM EDT • Business • entrepreneur.com

Will Howard is 'wired' the right way, and the Steelers believe it's been showing at OTAs

By now, Will Howard should be accustomed to learning a new playbook. After all, Mike McCarthy’s offense is his fourth in four years. But according...

May 25 • 4:00 AM EDT • Sports • post-gazette.com

As wildlife races poleward, scientists warn the old conservation playbook is breaking down

The changes are not happening in a simple, uniform pattern.

May 21 • 6:20 PM EDT • Science • yahoo.com

LA mayor's race: AI videos supporting Spencer Pratt shake up political playbook

AI-generated videos depicting L.A. mayoral candidate Spencer Pratt as a superhero and his rival Karen Bass as a villain are gaining traction online.

May 19 • 1:21 AM EDT • Politics • abc7.com

Sen. Bennet: Trump is running a ‘tyrant’s playbook’

May 18 • 9:38 PM EDT • Politics • cnn.com

Volpe Brings Style to the Bronx

With the New York Yankees & Anthony Volpe, Charles Tyrwhitt is bringing its decades-long playbook to one of sports’ biggest stages.

May 18 • 12:11 AM EDT • Sports • sports.yahoo.com

Sway a crowd, wear a martyr’s crown: how one NSW politician went from scandal to political success – and wrote a playbook still used today

At the turn of last century, an ambitious young solicitor caused a scandal in a high-profile murder case. Years later he was a political leader in a new nation. How did he do it?

May 17 • 11:00 AM EDT • Politics • theguardian.com

With Possible Raúl Castro Indictment, U.S. Eyes Venezuela Playbook

Amid stepped-up surveillance flights, a visit of the C.I.A. director and an energy embargo, the White House is trying to increase pressure on Cuba.

May 15 • 4:53 PM EDT • Politics • nytimes.com

Hantavirus outbreak tests post-COVID health communications playbook

A rodent-borne virus with a scary name. A mid-ocean cruise ship in quarantine. Several people dead and more falling sick.

May 15 • 2:02 AM EDT • Health • reuters.com

California governor frontrunner Xavier Becerra's playbook: Never say you're sorry

While other California governor candidates apologize for past mistakes, Democratic frontrunner Xavier Becerra has a different strategy: dodge and dismiss.

May 14 • 8:00 AM EDT • Politics • calmatters.org

Red Foxes’ Hudson Valley Entertainment Playbook

When the maples blaze and a cool breeze rolls off the Hudson, Poughkeepsie slips into its best season—festival weather, sweater weather, show-going weather. Marist College Red Foxes call this river city home, and the campus hum becomes a perfect launchpad for music and theater all over the Mid-Hudson region. From ornate 19th-century opera houses to big-sky amphitheaters that echo into the hills, autumn here is tailor-made for set lists and standing ovations. Consider this your locally tuned guide: a mix of chart shapers, roots revivalists, and Broadway juggernauts—plus the nearby halls that turn a crisp evening into a memory.

May 13 • 11:13 AM EDT • Entertainment • goredfoxes.com

FDA's New Playbook: Lots of Media Announcements but Not Much Rulemaking

WASHINGTON (AP) — In one of his first major announcements as health secretary, Robert F. Kennedy Jr. called a news conference to unveil a plan to “phase out” synthetic food dyes. Food and Drug Administration Commissioner Marty Makary opened the event by saying his agency was “removing all ...

May 7 • 9:06 AM EDT • Health • usnews.com

Opinion: Chicago companies offer a playbook for implementing place-based investments

On the South and West Sides of Chicago, place-based investments are bringing jobs, training and capital closer to home and advancing the city’s economy

May 6 • 9:30 AM EDT • Business • chicagobusiness.com

Wall Street opens up its partnership playbook for AI

Finance giants are teaming up with OpenAI and Anthropic to help them spin up consulting arms. It's a classic strategy Wall Street has deployed before.

May 5 • 9:28 AM EDT • Business • businessinsider.com

How an Alleged Child Predator Remade the Southern Baptist Convention in His Image

Paul Pressler helped ally evangelicals with the Republican Party. Many are still using his playbook.

May 4 • 7:00 AM EDT • Politics • texasmonthly.com

Global Health & WASH: May 2026 Funding Opportunities (14 new opportunities!)

The May update for Global Health & WASH brings new calls that cluster around three distinct shifts: LMIC research leadership moving from funder encouragement into a hard eligibility constraint, pharmaceutical and corporate-linked funders running structurally independent education and use-inspired research portfolios at substantial scale, and AI adoption shifting decisively from speculative tool to operational capability across health and WASH systems alike. In LMIC Research Leadership as Eligibility, Not Encouragement, Wellcome anchors the dominant signal of the month with three separate major calls that all require or strongly center LMIC leadership in their basic eligibility architecture. Wellcome’s ESIC Hubs (£1.5-£1.9M per hub over 3-5 years) explicitly requires an LMIC-based lead applicant, treating Global South leadership as a design constraint rather than a participation goal. Wellcome’s Infectious Disease Clinical Trial Development Award funds transdisciplinary teams whose lead must be a mid-career or established researcher based at an organization in Africa, South Asia, or Southeast Asia. Wellcome’s larger Infectious Disease Clinical Trial Award (£1M-£8M for optimizing licensed interventions) requires the administering organization to be in eligible LMIC regions and at least 50% of applicants based there. Around Wellcome, the same pattern shows up at smaller scale and across funders: CHINNOVA channels $1M into West and Central African research institutions for climate-health work; IBRO’s Neuroscience Training Grants explicitly tier ceilings by region of residence with Africa receiving the highest amount ($5,000); IHME’s GBD Emerging Researcher Award reserves at least one of its two annual awards for an LMIC researcher; Sidaction’s HIV Cure call funds research teams across France, the Netherlands, and eligible African countries with a minimum two-country collaboration requirement. Taken together, these calls signal a meaningful shift in how research equity is being operationalized — not as encouragement language at the bottom of a call, but as a structural feature of who can lead, where the work must be administered, and what proportion of the team must be regionally rooted. In Pharma-Funded Independent Medical Education and Use-Inspired Research, the lineup this month is unusually deep. Pfizer alone runs four parallel calls under independent education and quality improvement frameworks: a Migraine and Women’s Health RFP (200K x 2-year, $500K pool), Migraine IME ($200K, $1M pool), JAK Inhibitor evidence-based education ($100K), and Maternal Vaccination HCP Education in Saudi Arabia ($75K), plus a separate Pediatric Pneumococcal Surveillance research call in Saudi Arabia ($400K per project). Novo Nordisk Foundation runs four parallel calls of its own at substantial scale: Infectious Diseases Catalyst Grants (DKK 60M pool, up to DKK 7M collaborative), Non-Diabetic Endocrinology Collaborative Grants (DKK 53M pool, DKK 5-10M per project), Pioneer Innovator Grant Health (DKK 1.1M), and Distinguished Innovator Grant Health (DKK 6.8M). LEO Foundation deploys DKK 2-4M per project for dermatology research excellence. Pfizer’s framing across calls deliberately separates the funding from product promotion, emphasizing measurable practice-relevant change and structural distance between scientific outputs and commercial activity. Novo Nordisk’s “use-inspired” hard filter pushes researchers toward a credible translation pathway from mechanism to deployable tool. The pattern: industry-aligned funders are running structurally independent portfolios at meaningful $ that fund implementation evidence, not promotion. In AI as Operational Capability, Not Speculation, several calls this month explicitly treat AI adoption as a near-term operational question with real evidence and governance requirements, rather than a speculative trend to be watched. Wellcome’s ESIC Hubs frames AI as “the accelerator” for evidence synthesis, asking hubs to translate technical innovation into adoption-ready workflows that can match real-world policy timelines. UNICEF Venture Fund’s new Climate Tech for Children’s Health call funds for-profit startups deploying AI, machine learning, and blockchain in low-resource environments, with a strict requirement that solutions must already have a working prototype with promising pilot results. The Water Research Foundation has launched two simultaneous AI calls treating reproducibility, cybersecurity guardrails, and human-in-the-loop deployments as core design constraints rather than nice-to-haves: one on GenAI and Agentic AI in water utilities ($200K), one on alternatives to water shutoffs that explicitly screens for implementation economics evidence. Nordic Innovation’s quantum technology call (NOK 4.5M) extends the same logic into life science and healthcare, demanding consortium-stage projects mature enough to test with real users. TEF-Health offers €300K in subsidized testing infrastructure for European healthcare AI and robotics SMEs. The pattern: funders are converting AI pilots into playbooks, requiring transfer evidence and risk controls before AI can move from experimentation to sector-wide operational practice. For LMIC-based researchers in infectious disease or evidence synthesis, the three Wellcome calls together represent the deepest concentration of LMIC-led research capital in recent memory — pair the Infectious Disease Clinical Trial Development Award (£200K, deadline May 19) as a strategic pipeline feeder into the larger Infectious Disease Clinical Trial Award (£1-£8M, deadline June 2), since the development award functions explicitly as a track into the larger trial scheme. For Nordic researchers, the four Novo Nordisk Foundation calls plus LEO Foundation and Nordic Innovation Quantum represent ~$30M in regional research capital this cycle, all with deadlines clustered in May-August. For WASH practitioners, the three Water Research Foundation calls together (each up to $200K) are a cluster worth reading across — one on AI deployment, one on shutoff alternatives, one rewarding applied innovation — and the strongest applicants will articulate how their work bridges utility operations to policy-relevant evidence. For US-based clinical researchers and educators, the four Pfizer calls plus the APF Portfolio’s 80+ programs form an unusually accessible recurring pipeline; APF’s prohibition on indirect costs is a meaningful structural feature for early-career applicants whose institutions might otherwise absorb significant overhead. Snapshot of New Opportunities Total Estimated Funding Pool: $100 Million+ USD The grants are organized into three categories: Open Calls: Current grant and opportunities with a deadline. Grants are listed by closing date. 39 open opportunities- 14 new! Rolling Applications: current grant and opportunities with rolling applications (but it’s still best to submit as early as possible). 14 rolling opportunities- 1 new opportunity! Long term planning: Grants that have closed their current rounds, but are expected to open new windows. 4 long term opportunities! A quick tip for returning readers: if you want to jump straight to the newest additions, use CTRL F to search for “New!” and navigate quickly to the latest funding opportunities This post is for paid subscribers. This helps support the time and effort it takes to curate and organize these opportunities. Subscribe To keep this accessible to everyone who needs it, we’re happy to offer pay what you can rates. You can find more details here. Open Calls: Migraine Competitive Grant Program: Migraine and Women’s Health (Quality Improvement and/or Research RFP), Pfizer.*Closing soon!* Pfizer, in collaboration with the American Headache Society, is seeking independent quality improvement and research projects that close persistent gaps in migraine care for women across the United States. The funding logic centers on measurable, practice-relevant change: proposals should generate actionable evidence, tools, or system improvements that can be shared and used widely, not just within a single site. Priority areas span menstrual migraine and screening in women’s health settings, the role of hormonal fluctuations across the lifespan, sex-specific risk factors, comorbidities and quality-of-life burden, and disparities in outcomes by race, ethnicity, and socioeconomic status. The call is structured as a two-step competitive process with an initial Letter of Intent, with the strongest concepts expected to translate scientific insight into implementable improvements in diagnosis, management, and equity. Geographies: United States. Who can apply: U.S.-based organizations (not individuals), including professional schools, healthcare institutions, professional organizations, and other entities focused on healthcare improvement. Funding amount: Up to USD $200,000 total over 2 years; total pool USD $500,000. Targeted Sectors / SDGs: Health; Focus areas: migraine, women’s health, quality improvement, clinical research, menstrual migraine, health disparities. Deadline: LOI: May 5, 2026; Full proposal (by invitation): August 28, 2026. Learn more and apply here. This RFP rewards “shareable impact”: the most competitive submissions will pair rigorous methods with a clear plan for system uptake and dissemination beyond the originating institution. ReSSARC: Strengthening the Health Sector and Food Security in the Central African Republic (AID 013381/01/0) Call for Proposals, Italian Agency for Development Cooperation (AICS). *Closing soon!* AICS is seeking a limited set of high-capacity humanitarian partners to deliver an integrated package that stabilizes essential health services while reducing acute malnutrition and strengthening food security resilience in priority areas of the Central African Republic. The funder’s logic is explicitly nexus-based: proposals should meet urgent, life-saving needs while reinforcing local systems, coordination mechanisms, and community-level capacity so results persist beyond the emergency window. AICS emphasizes inclusion and protection outcomes, expecting gender-sensitive design and explicit measures for groups facing compounded vulnerability, including women, children under five, internally displaced people, and people with disabilities. The call also signals a localization pathway, encouraging stronger collaboration with national NGOs and balanced partnerships, alongside clear coordination with existing cluster and humanitarian actors to minimize duplication and improve coverage. Geographies: Central African Republic (Bangui, Ombella-Mpoko, Ouham, Ouham-Pende, Lim-Pende, Lobaye). Who can apply: Non-profit organizations registered with AICS, plus eligible non-profits without an office in Italy that have a pre-existing collaboration agreement with an AICS-listed organization. Funding amount: Total pool EUR €1,800,000; max EUR €800,000 (single applicant) or EUR €1,000,000 (ATS). Targeted Sectors / SDGs: Health; Focus areas: malnutrition prevention and treatment, maternal and child health, community health services, food security and resilience, localization partnerships Deadline: May 5, 2026. Learn more and apply here. This call is structured to reward partners who can link frontline service delivery to system durability and localization, not just short-term coverage gains. Contracts for Innovation in drug and alcohol addiction healthcare, Innovate UK. *Closing soon!* Innovate UK, on behalf of the Office for Life Sciences Addiction Healthcare Goals program, is procuring R&D to accelerate innovations that can improve treatment outcomes, strengthen recovery, and reduce harm and deaths linked to drug and alcohol addiction. The competition is positioned as a market-facing readiness push: selected projects are expected to advance solutions toward later-stage validation, generate evidence of user acceptability and UK market fit, and map credible routes through regulatory and certification requirements. Innovate UK signals a preference for innovations that can be field-tested in relevant UK settings and progressed to TRL 6 or 7, with practical plans for commercialization after contract completion. This structure favors applicants that can execute most work in-house, co-develop with service providers and people with lived experience, and translate technical progress into deployable tools for addiction healthcare delivery. Geographies: United Kingdom. Who can apply: Single organizations of any size (including EU, EEA, or international) leading delivery, with most work and key deliverables carried out in the UK; subcontractors for specialist skills only. Funding amount: GBP £200,000–1.5 million per project (inclusive of VAT); Total pool: GBP £20 million (across two strands). Targeted Sectors / SDGs: Health; Focus areas: Mental Health, Health Systems Strengthening, Research & Development, Technology Access. Deadline: May 6, 2026 (11:00am). Learn more and apply here. This call uses procurement to pull near-market addiction innovations toward operational proof and adoption pathways in UK services.

May 4 • 3:59 AM EDT • Health • impactfunding.substack.com

Branch Basics, A Homegrown Small Business, Shares Its Target Playbook

Branch Basics, the clean home care brand, spent over a decade building a loyal online following. Then landed on Target shelves last year and sold out of product. Here's how.

Apr 28 • 2:12 PM EDT • Business • forbes.com

Anta: The Chinese sports brand taking on Nike and Adidas

Now one of the biggest sportswear firms, Anta's rise follows a playbook adopted by many Chinese giants.

Apr 26 • 6:24 PM EDT • Sports • bbc.com

John Ternus could borrow from Microsoft’s playbook to reinvigorate Apple

Microsoft recently announced something rather interesting – a voluntary employee buyout. In short, if your age and tenure at the...

Apr 26 • 1:28 PM EDT • Technology • 9to5mac.com

The AI Playbook That Built an $80M 1-Person Business (You're 1 Prompt Away and Don't Know It)

If I lost everything tomorrow and had to rebuild to seven figures in 12 months using only AI, I wouldn't guess — I'd reverse-engineer the people who already did it.

Apr 24 • 8:00 PM EDT • Business • entrepreneur.com

Trump brings his nonsense about mail-in ballots to Republicans’ Virginia defeat

President Donald Trump has lied for years that elections Republicans lost fair and square were “rigged” by mail-in ballots. On Wednesday, he brought his familiar playbook to the aftermath of the Virginia redistricting referendum Republicans lost on Tuesday.

Apr 22 • 7:35 PM EDT • Politics • cnn.com

Virginia follows California, approves ballot measure to redistrict mid-decade

It’s been less than six months since California voters approved a new congressional map that could enable Democrats to flip as many as five House seats now held by Republicans. Now, Virginia is following the same playbook.

Apr 22 • 6:28 PM EDT • Politics • spectrumlocalnews.com

70% of people believe at least one divisive health claim. Science needs a new playbook

Edelman’s 2026 Trust Barometer finds doubts about health recommendations are far from fringe — they're mainstream, global, and span education levels.

Apr 22 • 5:30 AM EDT • Science • fortune.com

70% of people believe at least one divisive health claim. Science needs a new playbook

Edelman’s 2026 Trust Barometer finds doubts about health recommendations are far from fringe — they're mainstream, global, and span education levels.

Apr 22 • 5:30 AM EDT • Health • fortune.com

Cleveland’s workplace evolution: Why the old office playbook no longer works

Cleveland companies rethink office strategy to balance cost and employee experience, using flexible space and focusing on cognitive wellness.

Apr 20 • 5:00 AM EDT • Business • crainscleveland.com

House Democrats attempt anti-corruption message to gain traction against Trump

Days after Hungarian Prime Minister Viktor Orbán was ousted by an opposition campaign with an anti-corruption message, Democrats want to try the same playbook against President Donald Trump before the midterm elections.

Apr 15 • 7:22 PM EDT • Politics • pbs.org

Valvoline reveals its FIFA World Cup marketing playbook

Valvoline, an official FIFA World Cup 26 "supporter," is preparing to launch its largest-ever marketing push.

Apr 15 • 7:30 AM EDT • Business • businessinsider.com

Merlin Entertainments: Liability Management Playbook for the Senior Notes

Discover the Merlin Entertainments Liability Management Playbook and understand refinancing options, covenant flexibility, and structural risks facing the senior notes.

Apr 15 • 6:57 AM EDT • Entertainment • know.creditsights.com

Trump and MAGA Embraced Orban. Now, They’re Worried by His Loss in Hungary’s Election.

Viktor Orban, the Hungarian prime minister, and his right-wing playbook were embraced by parts of the American right. Now some are worried by his defeat.

Apr 13 • 8:56 PM EDT • Politics • nytimes.com

A Shot to Lose Weight, Then a Pill to Keep It Off

America has a new GLP-1 playbook.

Apr 11 • 7:30 AM EDT • Health • theatlantic.com

Sports Playbook for Business: Leading with Speed, Clarity, and Purpose

Novo Nordisks Aleksandar Ciric writes that leaders can apply sports principles such as speed of action, clarity, and responsiveness to be successful in life sciences.

Apr 10 • 1:49 AM EDT • Business • lifescienceleader.com

Age-Friendly Kansas: Three-Year Action Plan

Age-Friendly Kansas Three-Year Action Plan: Promoting connection, reducing isolation and integrating healthy aging across sectors through practical strategies developed with state and national partners.

Apr 9 • 7:39 AM EDT • Health • khi.org

LA business groups unite behind Bass and switch up their playbook

For the first time, the city’s fragmented business interests are coordinating their political efforts.

Apr 7 • 9:00 AM EDT • Business • politico.com

Health Law Navigator: The Compliance Department vs. The Machines: A Playbook for Using AI

In 2026, health care facilities are under relentless pressure to use AI. From diagnostic algorithms that outperform radiologists to predictive

Apr 6 • 12:58 PM EDT • Health • spencerfane.com

Legendary sports agent Leigh Steinberg joins 'GMFB' to discuss his new book

Legendary sports agent Leigh Steinberg wakes up with "GMFB" to discuss his new book "The Comeback - A Playbook for Turning Life's Setbacks Into Victories" and the 30th anniversary of "Jerry Maguire" film.

Apr 6 • 10:17 AM EDT • Sports • nfl.com

McKinsey's new AI leadership playbook: flatten teams and move faster

McKinsey and other consulting firms are using AI to streamline management structures — what some call The Great Flattening.

Apr 3 • 5:04 AM EDT • Business • businessinsider.com

How to Get a Tariff Refund

Thousands of businesses have a shot at getting some money back from the US government—but there will be a playbook.

Apr 2 • 7:00 AM EDT • Business • bloomberg.com

The Authoritarian Playbook: The sexual politics of meat under Trump

Feminist scholar Carol Adams argues that the oppression of women and animals is inextricably linked. She asks: What can meat eating tell us about Western authoritarians?

Apr 1 • 7:12 AM EDT • Politics • kalw.org

Want to renew healthy eating habits? Greek monks have a spring playbook

Across Greece and in Orthodox communities around the world, a centuries-old Lenten fast offers a modern lesson in diet and discipline.

Apr 1 • 1:07 AM EDT • Health • seattletimes.com

Schumer had a plan to win back the Senate, but some Democrats aren't on board

Democrats are fighting over whether the party's traditional playbook still works in a country that elected Donald Trump for a second time — and whether leaders like Schumer should remain in charge.

Mar 31 • 4:42 PM EDT • Politics • pbs.org

The Gold IRA Playbook: Everything to Know About Investing in Gold for Retirement

Learn how gold IRAs work, who should open one, how they're priced, and how to find a company you can trust.

Mar 31 • 1:24 PM EDT • Business • businessinsider.com

Inc. Names Interactive Entertainment Group Inc. to 2026 List of the Fastest-Growing Private Companies in the Northeast for the Fourth Time

/PRNewswire-PRWeb/ -- Inc., the leading media brand and playbook for entrepreneurs and business leaders shaping the future, today announced that Interactive...

Mar 31 • 7:00 AM EDT • Entertainment • prweb.com

DNC launches voter registration blitz, new playbook as Dems eye more Florida gains

Party leaders say the initiative is designed to rebuild Democratic infrastructure after years of voter registration losses and a widening GOP advantage.

Mar 30 • 4:30 AM EDT • Politics • floridapolitics.com

Edinburg Chamber Announces Business Conference Featuring Emmitt Smith

Texas Border Business By Roberto Hugo González / Texas Border Business The Edinburg Chamber of Commerce announced that former professional football player Emmitt Smith will serve as the keynote speaker for its upcoming business conference, “The Business Playbook,” scheduled for April 23, 2026, in Edinburg, Texas. The announcement was made during a press conference held […]

Mar 27 • 11:28 AM EDT • Business • texasborderbusiness.com

The Business of Bull Riding: CEO Sean Gleason Opens Up His PBR Playbook

Under Gleason, the Cowtown-based Professional Bull Riders has evolved into a made-for-TV, multibillion-dollar sports property.

Mar 23 • 8:00 PM EDT • Business • dmagazine.com