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Pioneer of China NewCo model sued in US over trade secret misuse, double-dealing
A legal feud unfolding in New York is putting a spotlight on the work of a business development veteran who is credited for pioneering one of biopharma’s hottest dealmaking mechanism: the China “NewCo” model. In a lawsuit originally filed in New York state court and recently moved to federal court, China’s Lepu Medical Technology has alleged that biopharma business development consultant Su Zhang, who was hired to help shop its GLP-1 weight-loss candidates to Western partners, engaged in corporate double-dealing and trade secret leaks. According to the complaint, while acting as Lepu’s primary dealmaking liaison for a group of obesity and metabolic disease drug candidates, Zhang was secretly double-dipping as the acting chief business officer for a direct competitor, BrightGene Pharmaceutical. “She never adequately disclosed the role, never sought Lepu’s consent, and never proposed any safeguard,” Lepu alleged in its complaint, which was filed in July after Zhang’s consulting firm, CoDevCo, sought certain transaction-based success fees from its angry customer through an arbitration process in Singapore. Lepu, the parent company of Lepu Biopharma, has asked Zhang to pay back its $500,000 retainer and disgorge all benefits she received during the alleged breaches of fiduciary duty, plus other damages and relief. The company has also requested the court grant injunctions to protect Lepu’s trade secrets. The ill-fated partnership officially kicked off in December 2024, when Lepu tapped CoDevCo as its “exclusive business development mechanism” to identify collaborators for the company’s drug candidates. According to Lepu’s complaint, Zhang personally negotiated and signed the agreement as managing director for CoDevCo, which used her home address. Before the Lepu deal, Zhang made a name following a short stint as the global head of business development for Hengrui Pharmaceuticals. It was during her tenure that Hengrui signed a landmark deal granting exclusive rights for a portfolio of GLP-1 assets to Hercules, which was at that time newly established by a group of private equity and venture capital firms. In addition to the regular upfront and milestone payments, Hengrui also gained an equity stake in Hercules, which later became Kailera Therapeutics. The Hengrui-Hercules deal opened a new paradigm, where a Chinese biopharma company spins off certain early-stage assets to investors for further development through the creation of a new company abroad. The “NewCo” model quickly came into vogue as it allows Western investors to access high-potential assets originating from China at an early stage while giving the Chinese licensors an opportunity to reap long-term benefits through equity stakes in the new firms. The NewCo model proved its value when Kailera staged a record-breaking $625 million IPO on Nasdaq this April, merely two years into the Hengrui deal. Related Kailera CEO 'knew we were in a good spot' before obesity biotech's record-breaking $625M IPO On her LinkedIn page, Zhang described her work at Hengrui as “[b]uilding team and capability from the ground up,” forming NewCo and major pharma partnerships worth billions of dollars. Lepu clearly wanted that kind of track record to help boost its own cardiometabolic portfolio, which includes a range of assets for obesity, Type 2 diabetes, fatty liver disease and muscle preservation during weight loss treatment. “Lepu’s pipeline is very valuable, but only if Lepu could secure the right international partner to expand into the overseas market during the available commercial window,” the company argued in its complaint. The Chinese biotech said it had little knowledge of U.S. laws, customs or business practices in the business development field, and therefore “needed to rely entirely” on the expertise of Zhang and her team as the firm’s first engagement of a U.S.-based BD consultant. “Zhang’s dominating influence on the business development strategy is further evidenced by the fact that she personally controlled the business-development communications on behalf of Lepu with potential partners,” Lepu said in its complaint. After entering the deal, Zhang introduced Lepu to her four associates. According to Lepu’s version of events, all of them were allegedly employed at different time points to perform similar jobs at other Chinese companies that Lepu described as its competitors, while having access to Lepu’s confidential information. As such, Lepu described Zhang’s team as “a roster of individuals whose primary professional loyalty, by virtue of their concurrent full-time employment, ran to Lepu’s competitors.” As well as the specific examples set out in the case, a look at Lepu’s deals over the period suggests Zhang may have been involved in at least one transaction. During their partnership, Lepu, through its subsidiary Shanghai Minwei Biotechnology, also out-licensed its GLP-1/GIP/FGF21 agonist MWN105 to a NewCo called Sidera Bio in the fall of 2025. The deal included an upfront and near-term payment of $35 million, up to $1.01 billion in milestones, and a 9.99% stake in the Danish startup. It seems likely that Zhang facilitated the Minwei deal given that Lepu is on record as having used CoDevCo as its “exclusive business development mechanism.” The big shock for Lepu came in the form of a news article on June 25, 2025. The article, reporting on phase 2 data for BrightGene’s GLP-1/GIP receptor agonist BGM0504, identified Zhang as acting chief business officer of the Lepu rival. Blindsided by her association with BrightGene, Lepu confronted Zhang in July 2025. “Lepu was given assurances that there was nothing to be concerned about and told that Zhang would explain the matter to Lepu,” Lepu alleged in its complaint. “Zhang never did.” Lepu claimed that Zhang had the motive and opportunity to steer potential prospective partners toward BrightGene or other competitors. Later, in February 2026, one of Zhang’s associates joined BrightGene as the vice president for global business development, according to the complaint. Around the same time, Lepu sent written demand letters asking Zhang to account for her BrightGene role, identify what confidential data were shared with the rival firm, and provide any conflict-of-interest or firewall policies during the engagement. According to Lepu, neither CoDevCo nor Zhang answered the questions in their responses. Related Novo vs. KBP: How a $1.3B deal turned into a fraud accusation and an international legal fight In a motion to dismiss filed with the U.S. District Court in the Eastern District of New York on Sept. 4, Zhang’s legal team argued that Lepu’s agreement was signed with CoDevCo, and that an employee of the contractor does not owe fiduciary duties to the client. In its complaint, Lepu said: “That CoDevCo was the contracting entity does not insulate Zhang from personal liability for duties she personally undertook and personally breached.” Taking the argument one step further, the defending party argued that the consulting agreement “does not create a fiduciary relationship even between CoDevCo and Lepu; instead, it identifies CoDevCo as an independent contractor retained to market Lepu’s business to potential western partners.” Although CoDevCo was Lepu’s exclusive business-development contractor, there were no terms stipulating that the consulting firm should serve only Lepu, Zhang’s lawyer noted. As to Lepu’s claims that Zhang misappropriated trade secrets, the defendant argued that Lepu authorized the use of the information so Zhang’s team could perform their service per the agreement. In a rebuttal filed on Sept. 11, Lepu’s lawyer set out why they believe the Chinese biotech satisfied New York law’s misappropriation definition by alleging that the defendant used a trade secret “in breach of a duty or through improper means.” As an alternative to dismissing the suit, the defendant suggested the action should be stayed pending outcomes from the arbitration of a separate case in Singapore. While NewCo pioneer Zhang is defending her business arrangements, momentum behind the NewCo trend has continued unabated into 2026. Through August, Chinese biotech assets have spurred 15 NewCo deals this year, according to local trade publication PharmaDJ.
Matthew Golden tallies first regular-season TD
Matthew Golden saw a game-high 12 targets, which led to 100 yards on five receptions and his first regular-season touchdown in the NFL.
Armacost honored among Prairie Business’ 2026 Leaders & Legacies
UND president recognized at reception celebrating seven regional leaders for their leadership, community impact and vision
ENTERTAINMENT: ‘Barbie and Friends’ come to ESSE Museum; Laman library hosts wrestling
ESSE Museum & Store opens “Barbie and Friends” with a 5-8 p.m. Thursday opening reception that offers the opportunity to “meet two real live Barbies in person,” according to a news release.
DeVonta Smith stands two catches from Eagles franchise history
DeVonta Smith needs two receptions against Chicago to become the fastest player in Eagles history to reach 400 career catches
Situation Report No.11: Earthquakes in Venezuela 2026 (M7.2 and M7.5)
Nearly three months after the 24 June 2026 earthquakes in Venezuela, the response has moved into early recovery while sustaining essential emergency operations. Efforts now center on maintaining continuity of care across mental health, sexual and reproductive health, maternal and neonatal care, NCDs, and rehabilitation, alongside restoring affected facilities, supporting transitional camps, and strengthening Health Cluster coordination as Emergency Medical Teams and international partners withdraw. Health system recovery is advancing, with 16 ASICs and 356 health facilities assessed (61% operational) and rehabilitation progressing under CERF, CFE and US funding, while fluctuating electricity, medication refrigeration and emergency-generator gaps continue to challenge the safe continuity of essential health services. Public health surveillance and prevention remain active, with 47,145 cumulative vaccine doses administered and 556 health professionals trained, while intensified surveillance in La Guaira and Miranda and mounting environmental risks from tropical rains and heatwaves continue to require sustained vector-control and water/sanitation action. Contraception remains the most consistent unmet need across assessed shelters, particularly among adolescents and young women, while mental health needs continue to rise across the transitional camps amid limited supplies and specialized personnel. PAHO/WHO continues to support the response with critically needed medical supplies and medicines, having shipped 46.6 metric tons to Venezuela to date, benefiting 72 actors and reaching 117,714 people with treatment through PAHO and partner donations, while sustained technical and logistical support to the Ministry of Popular Power for Health (MPPS) has strengthened the national supply chain and ensured the continuity of health services through the coordination, reception, and mobilization of international donations of essential medical products.
Trey McBride reaches end zone in Week 2
Cardinals TE Trey McBride leads team in receptions and receiving yards in Week 2
Spain on alert over potential new migrant crossing into Ceuta
Albares said Rabat was 'receptive' to tackling online calls for young Moroccans to cross into Ceuta
Holiday Event & Entertaining Guide 2026
As Orange County’s business calendar turns toward the holidays, where you gather says as much as what you serve. OCBJ’s Holiday Event & Entertaining Guide profiles the venues and culinary destinations setting the standard for the season, from client receptions to team celebrations to entertaining at home. This year’s lineup spans the county’s most distinguished […]
Four grabs for Malik Washington
Malik Washington led the Dolphins with four receptions against the 49ers in Week 2, turning those catches into 43 yards in the loss.
Eighty-three yards for Rashee Rice in prime time
Rashee Rice racked up 83 yards on four receptions during KC's Week 2 win over the Colts.
Nothing from Keenan Allen on SNF
Keenan Allen was targeted five times on Sunday night but finished with just one reception.
Chiefs grab 33-30 win in overtime thriller
KANSAS CITY, Mo. (KSNT) — Victory is secured in an overtime thriller. Patrick Mahomes finished the night 32-for-47 with 382 yards and three touchdowns. Kenneth Walker III picked up his second-straight game with over 100 yards for the Chiefs, with 117 yards on 24 carries. Travis Kelce had nine receptions for 101 yards and a […]
Tre Tucker hits triple digits with TD
Las Vegas Raiders wide receiver Tre Tucker racked up five receptions for 119 yards and a touchdown on seven targets in Week 2
Ashton Jeanty totals 63 scrimmage yards
Las Vegas Raiders running back Ashton Jeanty ran 21 times for just 48 yards in Week 2, while adding four receptions for 15 yards on seven targets.
Jake Ferguson scores pair of touchdowns
Dallas Cowboys tight end Jake Ferguson posted four receptions for 43 yards and two touchdowns on four targets in Week 2
George Pickens secures six receptions
Dallas Cowboys wide receiver George Pickens posted six receptions for 40 yards on eight targets in Week 2
CeeDee Lamb crushes Washington again
Dallas Cowboys wide receiver CeeDee Lamb registered eight receptions for 153 yards and two touchdowns on nine targets in Week 2
Stefon Diggs catches TDs from two different QBs
Washington Commanders wide receiver Stefon Diggs posted five receptions for 47 yards and two touchdowns on six targets in Week 2
Terry McLaurin good for 50 receiving yards
Washington Commanders wide receiver Terry McLaurin registered two receptions for a team-best 50 yards in Week 2
Just two catches for Tucker Kraft
Green Bay Packers tight end Tucker Kraft posted two receptions for 15 yards on three targets in Week 2
Matthew Golden leads team with 58 yards
Green Bay Packers wide receiver Matthew Golden posted four receptions for a team-high 58 yards on six targets in Week 2
MarShawn Lloyd scores TD in Week 2
Green Bay Packers running back MarShawn Lloyd rushed six times for just 20 yards in Week 2, while adding two receptions for six yards and a touchdown
Harold Fannin Jr. totals five receptions
Cleveland Browns tight end Harold Fannin Jr. had five receptions for 54 yards on six targets in Week 2
Denzel Boston records another long TD
Cleveland Browns wide receiver Denzel Boston finished with five receptions for a game-high 95 yards and a 55-yard touchdown in Week 2
Rashod Bateman productive in Week 2
Ravens WR Rashod Bateman posts team highs in receptions and receiving yards in Week 2
Rome Odunze secures four receptions
Chicago Bears wide receiver Rome Odunze posted three receptions for 43 yards on four targets in Week 2.
Five receptions for Devaughn Vele
Saints WR Devaughn Vele productive with five catches and 64 yards
T.J. Hockenson totals three receptions
Minnesota Vikings tight end T.J. Hockenson ended up with three receptions for 29 yards in Week 2
GOP Rep. Salazar says she spoke with Trump and he is ‘very receptive’ to her warning about Hispanic voters
GOP Rep. Maria Elvira Salazar Sunday said that President Donald Trump was “very receptive” to her warning that Hispanic voters feel “betrayed” by his immigration agenda ahead of the midterm elections.
Justin Jefferson’s next catch will be historic one for Vikings
Justin Jefferson can make Minnesota Vikings history Sunday against the Chicago Bears, needing just one catch to surpass Hall of Famer Randy Moss for second-most receptions in franchise history.
Flora’s all-around day leads Iowa State over Bowling Green
For the first time in school history, Iowa State returned a kickoff and a punt for a touchdown. Jaylen Raynor threw for 133 yards and one touchdown to true freshman Jamal Polite Jr. and Iowa State defeated Bowling Green 55-7 on Saturday. Cam Pettaway, a Bowling Green transfer, had three receptions for 47 yards and […]
TST Best Bets: September 19, 2026
Lane Kiffin’s return to Oxford was always going to be loud. After leaving Ole Miss for LSU last season, he’ll walk back into Vaught-Hemingway Stadium on Saturday as the coach of one of the Rebels’ biggest rivals. With both teams ranked in the top 10, there’s plenty at stake beyond the reception Kiffin gets.Earlier in the day, No. 16 SMU visits No. 23 Louisville in a ranked ACC matchup. The Mustangs have opened 2-0, while the Cardinals have a chance to make an early statement at home after a 1-1
Commanders' Terry McLaurin reacts to lack of Week 1 targets
Washington Commanders top receiver Terry McLaurin says there are "other ways you can affect the game" after having only two receptions in the opener.
It’s not personal: US Supreme Court justices focus on law, not politics
Justice Amy Coney Barrett told a UVA audience justices get along even in disagreement, but the job can be lonely.
Survey: Gen Z most receptive to political yard signs
UPrinting reports Gen Z is more responsive to political yard signs than older generations, with 22% influenced by them, despite fearing political discussions.
Supreme Court pushes back against Trump and GOP ahead of the midterm elections
The Supreme Court’s recent rulings on mail-in ballots and redistricting foreshadow a frosty reception to further attempts to change the rules before the election, experts said.
Meteor Pulse Launches Hiiiilo, an AI WhatsApp Receptionist
Kuala Lumpur agency Meteor Pulse has launched Hiiiilo, an AI-powered WhatsApp receptionist that answers, books and suggests add-ons for Malaysia...
Courtland Sutton limited to two catches
Denver Broncos wide receiver Courtland Sutton posted two receptions for just 11 yards on five targets in Week 1
Matthew Golden amasses 95 yards in loss
Matthew Golden was targeted a game-high 12 times, turning that into 95 yards on six receptions.
Six receptions in return for Malik Nabers
Back in action for the first time in almost a year, Malik Nabers caught six passes for 69 yards on Sunday Night Football.
Darren Waller makes two catches in Carolina debut
Darren Waller debuted for Carolina, making two receptions in Week 1
Travis Etienne Jr. racks up seven receptions
Travis Etienne Jr. debuts with 46 rushing yards, seven catches
Carnell Tate finishes with 38 yards in debut
Titans WR Carnell Tate posts four receptions and 38 yards against Jets
Business the focus at reimagined State of Surf City at Pier Plaza
A business and city department showcase, business leadership panel and VIP reception highlighted Thursday night's event in Huntington Beach.
Scientists Think Flipping a Single Switch in Your Body Could Slow Down Aging
Aging is a complicated puzzle, but one of its biggest pieces might be a receptor that fails to clear away damaged, senescent cells.
The iPhone Duo enters China’s crowded foldable market — and faces a price test
Chinese netizens focused on the price of Apple’s iPhone Duo, as cheaper Xiaomi and Huawei foldables raise value comparisons and muddle the foldable's reception.
Scientists find a bone-building switch that could fight osteoporosis
An experimental compound called AP503 significantly strengthened bones in mice by activating GPR133, a receptor that boosts bone formation while slowing bone loss. Because the same treatment has also been linked to stronger muscles, researchers see intriguing potential for combating age-related decline and osteoporosis.
Scientists engineer ready-to-use cancer-fighting T cells for solid tumors
T-cell receptor, or TCR, therapy is a cancer treatment that genetically reprograms immune cells, called T cells, to hunt down cancer with precision. It's similar to another treatment, CAR T-cell therapy, ...
Justin Jefferson Gets Blunt Prediction Before Vikings-Packers Game
The 2025 NFL season was a challenging one for Minnesota Vikings wideout Justin Jefferson. Due to the quarterback play, Jefferson barely recorded over 1,000 receiving yards. The Vikings star recorded an 80.5 PFF grade along with 84 receptions on 140 targets, 1048 receiving yards, and one touchdown.Moreover, Jefferson registered 12.5 yards per reception, 5.2 yards […] The post Justin Jefferson Gets Blunt Prediction Before Vikings-Packers Game appeared first on HEAVY.
Topeka-native Tre Richardson shines in Louisville debut
LOUISVILLE (KSNT) — An impressive debut on the national stage. Topeka-native and Highland Park alum Tre Richardson made his debut for the Cardinals on Sunday night when No. 24 Louisville took on No. 9 Ole Miss in the Music City Kickoff. Richardson picked up four receptions and 83 receiving yards and 30 rushing yards, with […]
"We truly feel this demo will dispel any kinds of uncertainty or concerns that people may have had" - Final Fantasy Resonance Director & Producer on the audience's positive reception after finally being able to play it
Director Hiroto Furuya and Producer Keisuke Nakashima spoke with us the day after the Final Fantasy Resonance demo came out, so we got to chat about their relief at finally being able to release something that people can play for themselves.
Art & Science Combine in Digital Art Exhibition in Portland in October
Unlikely Universes is an exhibition of Ann Tracy's digital works on canvas, metal and paper; the show opens with an artist's reception from 5:00 to 8:00
Cass Tech (MI) touchdown reception named USA TODAY Sports Play of the Week
The touchdown connection was one of many touchdowns Cass Tech scored in its season-opener.
ENTERTAINMENT: Watercolor exhibition opens at LR Visitor Center; Festival Ballet sets season
Watercolors by Laura Remmel Powers go on display with a 6-7:30 p.m. reception Tuesday at the Little Rock Visitor Information Center.
FDA approves tirzepatide for reducing cardiovascular risk in adults with type 2 diabetes
The popular drug, sold by Eli Lilly and Company under the brand name Mounjaro, has been at the center of many cardiology trials over the years. It is now the first dual GIP and GLP-1 hormone receptor agonist approved by the FDA for this indication.
Apple Reportedly Lays Off 60 Vision Products Group Employees
Apple "has just laid off an entire team dedicated to VR development," reports AppleInsider, citing its own source. Apple is said to have laid off at least 60 employees from its Apple Vision Group. Bloomberg's Mark Gurman previously reported that the Vision Pro team was disbanded and its members redistributed across other projects, following the October 2025 refresh of the Vision Pro and the headset's weak reception.
Community Invited To Opening Reception For New Environmental Stewardship Exhibit At Bradbury Science Museum Aug. 25
A new exhibit on the Lab’s environmental stewardship opens Aug. 25 at the Bradbury Science Museum, 1450 Central Ave. in downtown Los Alamos. Photo Courtesy LANL LANL NEWS RELEASE Beginning Aug. 25,…
Review reveals how nicotine damages blood vessels and heart health
A review published today in Nature Reviews Cardiology provides the most detailed picture yet of how nicotine damages the cardiovascular system – tracing the biological chain of events from the moment nicotine binds to receptors in blood vessel walls through to the atherosclerotic plaque rupture that triggers heart attacks and strokes.
Scientists solve the mystery of a brain “switch” that can trigger weight loss in opposite ways
Scientists have uncovered why two seemingly opposite ways of targeting the same brain receptor can both promote weight loss. In mice, activating the GIP receptor in the brainstem reduced appetite, while blocking it in the hypothalamus removed a kind of “brake” on fullness signals. The discovery helps explain why very different obesity drugs can achieve similar results and suggests that carefully combining GIP-targeting treatments with GLP-1 drugs like those related to Wegovy and Ozempic could produce stronger effects.
Ozempic may have revealed the brain’s hidden “craving center”
Ozempic-like drugs appear to weaken more than hunger—they may also reduce cravings for alcohol and other addictive substances. Scientists are increasingly tracing this effect to the lateral septum, a brain region that helps connect memories and surroundings with rewarding experiences. Packed with GLP-1 receptors, it may act as a crucial control point between thinking about a reward and feeling compelled to pursue it. The discovery could open new approaches to treating addiction as well as obesity.
NFL's best WR reveals two cornerbacks that are his kryptonite
Since the moment he stepped on an NFL field out of LSU in 2021, Ja'Marr Chase has been one of the best wide receivers in the league. The 81 receptions, 1,455 yards and 13 touchdowns he put up in his rookie season would be a career year for more than a few top-tier wide receivers. He has never had ...
Former NCCU Director of Athletics Dr. Wicker McCree Named Women Leaders in Sports Nike Lifetime Achievement Honoree
Durham, N.C. - Former North Carolina Central Director of Athletics Dr. Ingrid Wicker McCree, who retired from NC Central after 30 years of service as a coach and administrator in 2021, was announced as a Nike Lifetime Achievement Award honoree by Women Leaders in Sports on Tuesday.
Sanofi suspends chronic lung disease phase 2 study, tied to ‘strategic business reasons’
Sanofi halted a phase 2 trial testing a monoclonal antibody, SAR445399, in non-cystic fibrosis bronchiectasis, Fierce Biotech has learned. The trial, which began only back in April, was a randomized, double-blind, placebo-controlled study to measure the reduction in mucus plug score following treatment with SAR445399 compared with placebo in adults aged 18 to 80 years with NCFB, a chronic lung disease. The trial was officially reported as halted on July 29, the day before Sanofi’s second-quarter earnings call. The decision to pause the trial was made “as part of a company-wide portfolio review for strategic business reasons,” and not due to safety concerns, a Sanofi spokesperson told Fierce. The move to pause the NCFB trial comes during a trying time for Sanofi following a year filled with a series of trial fails. In February, the French pharma ousted CEO Paul Hudson and appointed Merck KGaA leader Belén Garijo, M.D., Ph.D., to steer the ship. Since then, Garijo has been doing a deep dive on correcting the company’s strewn R&D and clinical strategies. On July 24, Sanofi scrapped amlitelimab for atopic dermatitis, despite its lore as being a potential $5 billion blockbuster. During its second-quarter report, the company abandoned two more assets, balinatunfib and itepekimab, following failed trial results in psoriasis and chronic obstructive pulmonary disease, respectively. SAR445399, only first revealed by Sanofi in 2023, is an anti-interleukin-1 receptor 3 monoclonal antibody developed to block the interleukin 1, 33, and 36 cytokine pathways. These pathways can be important in chronic immune-related dermatologic diseases, such as atopic dermatitis and hidradenitis suppurativa, as well as respiratory conditions, such as NCFB. Related Sanofi’s new CEO ‘looking deeply’ at late-stage pipeline as clinical clearout continues NCFB affects roughly half a million people in the U.S., with a global incidence of greater than one million cases. In August 2025, Insmed received FDA approval for Brinsupri, a DPP1 inhibitor targeting neutrophil activation, for treatment of NCFB in adults and kids ages 12 and older. The British biotech Infex Therapeutics showed promising NCFB phase 2a data using their monoclonal antibody, INFEX702, which acts by disabling Pseudomonas aeruginosa, a bacteria known to be a major pathogen of NCFB. Sanofi is currently running a separate phase 2 study testing SAR445399 as a potential treatment for the inflammatory skin condition hidradenitis suppurativa.
The Beauty Of Settled Science
Commenters convinced me I made a subtle mis-step in my framing of Psychology Research Is Mostly Fine. My framing emphasized that social priming studies had failed to replicate, but that many other subfields of psychology hadn’t. This naturally led commenters to point to failed replications in other subfields. Although none of these were as bad as social priming, few or none were entirely problem-free. Instead of emphasizing the difference between social priming and other subfields, I should have emphasized the difference between settled science and novel research. Here are some of my favorite psychology findings: The brain is sculpted by reinforcement learning, and a key driver of this learning is a prediction-error-based algorithm located in the nucleus accumbens and implemented through dopamine. Psychedelic drugs exert their effects through 5-HT2A receptors, pointing to a role for these receptors in some sort of construct like the balance between priors and new evidence. Certain cognitive functions are localized to certain brain areas (for example, impulse control to the frontal lobes; linguistic structure to Broca’s area, linguistic meaning to Wernicke’s area. But injure one of these areas, or render a certain function useless (eg a blind person having no more use for their visual cortex), and these mappings can gradually shift - suggesting that neurons are general-purpose compute whose specialization is a contingent fact about convenience and efficiency rather than a necessity. Most personality traits and general capabilities are about 50% genetic and 50% random, with little role for family environment or childhood history, with a few notable exceptions like partisan preference. Recent research complicates this story, but the further you go from this basic picture, the gnarlier the chains of indirect causation you require. Neurons fire together in “brain waves”, whose exact frequency corresponds with the character of consciousness; These divide neurons into natural subpopulations and linked graphs. The gamma rhythm corresponds surprisingly well to items in conscious awareness. GABA receptors seem to be involved in something like relaxation. By hitting different GABA receptors in different ways, you can modulate the exact type of relaxation you produce. Hitting GABA-A directly is too powerful and can cause dangerous levels of sedation, but allosteric modulation of GABA is an incredibly fruitful strategy that underlies drugs from benzos to barbituates to alcohol. If you know your GABA-A subunits, you can target specific subtypes of relaxation; for example, Ambien hits GABA-A1 and induces sleep. Memory divides somewhat fuzzily into bins of immediate-sensory, short-term, and long-term, with separate retrieval and storage functions, and separate systems for declarative vs. procedural learning. These can be harmed selectively, usually by hippocampal injury, so that some patients can remember their life stories but not form new long-term memories, or learn new skills like bike-riding but not new facts. The exact substrate of memory is unclear but seems to involve new synaptic connections between neurons in at least some way. The ability of modern psychology and psychiatry to treat mental illness is real but limited. SSRIs work for half or slightly fewer than half of patients; antipsychotics work with extreme side effects; benzodiazpines work but produce addiction and tolerance in many (not all) people. Most supplements are stuck in Poor Quality Study Replication Crisis Hell, but melatonin and l-theanine stand out as especially promising. Psychotherapy works with moderate effect size, but (with a few exceptions) seems to be more about the relationship with the provider than the details of the therapy itself. Mental hospitalization can sometimes defuse immediate crises but work less well than mental hospitals would like, with some studies showing overall negative effects. Schizophrenia is mostly genetic, but risk also increases with prenatal infection (especially rubella) and obstetric complications; there is suggestive evidence for roles of social stress and drug use (with psychedelics and marijuana making things worse, and nicotine if anything making things better). Bipolar and schizophrenia are so closely linked on a pathophysiological level that it seems like they might be the same disease; on the clinical level, they do seem to follow two separate courses/prognoses but can sometimes surprise clinicians by eg someone who seemed condemned to permanent schizophrenia unexpectedly recovering. The brain’s native reinforcement learning algorithms cash out in the phenomena of classical and operant conditioning; different reinforcement schedules reinforce at different levels, which can be exploited by bad actors to make especially compelling products (eg slot machines). None of these are immune to doubt. A few are speculative; one or two are genuinely unorthodox. But they’re all a step above one p = 0.049 paper that might not replicate. If they get overturned, they’ll be overturned by the same sort of genuine scientific shift that replaced Ptolemy with Copernicus or Lamarck with Darwin, not some sort of sordid discovery about someone entering random numbers into a spreadsheet. In 2008, Eliezer Yudkowsky wrote about The Beauty Of Settled Science: If you only care about scientific issues that are controversial, you will end up with a head stuffed full of garbage. The media thinks that only the cutting edge of science is worth reporting on. How often do you see headlines like “General Relativity still governing planetary orbits” or “Phlogiston theory remains false”? So, by the time anything is solid science, it is no longer a breaking headline. “Newsworthy” science is often based on the thinnest of evidence and wrong half the time—if it were not on the uttermost fringes of the scientific frontier, it would not be breaking news. Scientific controversies are problems so difficult that even people who’ve spent years mastering the field can still fool themselves. That’s what makes for the heated arguments that attract all the media attention. Worse, if you aren’t in the field and part of the game, controversies aren’t even fun. Don’t be embarrassed to read elementary science textbooks, either. If you want to pretend to be sophisticated, go find a play to sneer at. If you just want to have fun, remember that simplicity is at the core of scientific beauty [...] A steady diet of science news is bad for you: You are what you eat, and if you eat only science reporting on fluid situations, without a solid textbook now and then, your brain will turn to liquid. Psychology isn’t centrally the new paper in Annals Of Recently-Breaking News saying that an n=5 study showing that large portion sizes increase support for terrorism. Psychology is centrally ideas like brain waves, GABA receptors, reinforcement learning, twin studies, and connectionism. People who think differently are worrying too much about BREAKING NEWS!!!, and should stop. The key distinction isn’t “recent research in social psychology” vs. “recent research in cognitive/bio/behavioral psychology”, as my essay last week unfortunately implied. It’s recent research in general vs. the deposit of settled science, battle-tested hypotheses, and carefully-earmarked speculation. And part of the reason social priming in particular was such a disaster was that it defied that heuristic, building itself up over hundreds of studies until it approached or even entered the pantheon of settled science - before collapsing (5-HTTLPR was also sort of like this). This isn’t a claim that settled science is always right - Freud was “settled science” for a long time - just that there’s an intuitive distinction between the level of credence you should have in the existence of power posing vs. the existence of Broca’s Area. (I compounded this error by calling the last post “Psychology Research Is Mostly Fine”, which suggested I was talking about the new research rather than the settled science. I actually meant to distinguish between research-psychology-the-field vs. clinical-psychology-aka-therapy, but this framing unintentionally pushed against the point I wanted to make) Some commenters on the previous article understood this point, but challenged its weight. It’s very cool, they said, to know how many neurons are in which brain lobe, but the main way that Psychology affected their lives was through bad clickbait studies used to buttress dumb policies; some p = 0.049 study says that exposure to microaggressions makes minorities’ brains shrivel into raisins, and now their company has to implement punitive DEI or be sued for hazardous work conditions. I won’t dispute this as an accurate description of how the sausage gets made, but it’s worth examining the trains of thought that connect this observation to a campaign against psychology in general: The dumb woke psychology was wrong and bad, and I don’t have good heuristics for distinguishing dumb woke psychology from other psychology, so I’m going to assume it’s all wrong and bad. The dumb woke psychology was wrong and bad; it seems useful to punish/discredit psychology as a whole to assist my campaign against it, so for propaganda purposes I will try to discredit psychology as a whole. To people in the first camp, my response is: come on, your heuristics aren’t that bad. “Microaggressions makes minorities’ brains shrivel up like raisins” is in the woke category; “the hippocampal theta rhythm seems to be associated with both memory and pathfinding, suggesting an unexpected yet surprisingly compelling relationship between the two” is in the not-woke category, don’t play dumb here. To people in the second camp, my response is: deliberately exaggerated propaganda campaigns are bad and this is a confession, not an excuse. Inability to view science through anything but a political lens was what got us into this problem; doubling down on it is a temporary solution but a recipe for permanent disaster. If you pronounce entire fields of science to be acceptable collateral damage in your campaign against bad political actors, you will alienate not just scientists but patients, clinicians, and general lovers of truth. Instead, you can say the thing you mean - that woke partisans shouldn’t try to occupy and exploit the otherwise-noble science of psychology for their own political gain - and wage the same campaign with a halo rather than a comic-book-villain goatee. From the font of oracular wisdom that is Weird Sun Twitter: [ Vessel Of Spirit@VesselOfSpirit i love you all conditionally but i love the good part of you unconditionally. even if it becomes a very small part 2:11 AM · Jan 22, 2015 1 Reply · 5 Reposts · 29 Likes ](https://x.com/VesselOfSpirit/status/558084551772471298) This is how I feel about psychology1, too, but with a touch more optimism. The good part of psychology is enormous, a hoard of endless treasures. You just have to look past the headlines! 1 To play devil’s advocate - should one always be so magnamious? Astrology? Phrenology? These seem different in that their entire orientation was flawed from the start; they didn’t simply fail to find the correct constellation-personality connections, the whole project of searching for connections between constellations and personality was doomed from the start. More difficult might be asking the same question about education research, which is notoriously bad. I don’t know enough about education research to know if there’s some settled science of correct and enlightening results lurking in the background beyond the day-to-day froth of poorly-conducted and politically-motivated studies. I think if it’s 90% bad, 10% good, it’s correct to call it bad as a compact way of communicating a useful truth; I think psychology is better than that, but admit it’s a tough judgment call.
Graduate School of Management to host annual Welcome Reception, August 25
Students, alumni, faculty and staff are invited to celebrate the start of a new academic year.
Northern Kentucky Magazine to induct four into 8th Annual NKY Business Hall of Fame
Staff report Northern Kentucky Magazine will present its 8th Annual NKY Business Hall of Fame celebration on August 12, 10:30 a.m.-1:30 p.m. at Receptions in Erlanger. The new inductees are…
S&T honors Dennis and Janet Jaggi for transforming business education
Dennis and Janet Jaggi pose on July 30 with family members by the sign bearing their name in S&T’s Engineering Management Building with the whole family on July 30 in front of their sign in Engineering Management during the reception in their honor. From left: daughter-in-law Christie Jaggi, son Greg Jaggi, Dennis, grandson Nicholas Jaggi,...Continue Reading S&T honors Dennis and Janet Jaggi for transforming business education
$4 Million Commitment Will Help UT Health Sciences Expand Health Hubs to Bring Preventive Care to More Communities Across Tennessee
Community and healthcare leaders, friends and partners of UT Health Sciences gathered to celebrate UnitedHealth Group’s announcement of a $4 million commitment to expand the neighborhood health hub model developed at the university from five to 13 across the state by the end of 2027.
Splatoon Raiders' User Scores Are Off To A Splashing Start On Metacritic
Nintendo's fresh take receives a glowing reception
Good Office Design Is Good Business
And this suburban Boston project proves it.
Business briefs: Braun honors five Hoosiers at Black Expo
Gov. Mike Braun recently recognized five Hoosiers at the Governor’s Reception at the Indiana Black Expo Summer Celebration.
Why aren’t health insurers rushing to cover GLP-1 prescriptions for beneficial weight loss?
In theory, GLP-1 receptor agonist drugs like semaglutide and tirzepatide should save a lot of money for the health insurers that pay for them. As it turns out, the lived reality is not keeping pace with the idealistic expectation.
Sports and politics: No longer strange bedfellows
Sports has always billed itself as above petty indifferences, something that brings people together on the sanctity of the playing field. FIFA, the guardian of the soccer World Cup pledges to ensure accessibility to everyone, promising that each athlete will receive a reception that is “safe, welc...
Coffee may help the body fight stress and aging through a hidden cellular switch
Scientists may have uncovered one reason coffee is repeatedly associated with healthier aging and lower disease risk. Compounds in coffee appear to activate NR4A1, a receptor that helps protect cells from stress, inflammation, and damage. These protective effects disappeared when the receptor was removed, strengthening the connection. Surprisingly, plant-based compounds such as caffeic acid seemed far more active than caffeine itself.
Coffee may help the body fight stress and aging through a hidden cellular switch
Scientists may have uncovered one reason coffee is repeatedly associated with healthier aging and lower disease risk. Compounds in coffee appear to activate NR4A1, a receptor that helps protect cells from stress, inflammation, and damage. These protective effects disappeared when the receptor was removed, strengthening the connection. Surprisingly, plant-based compounds such as caffeic acid seemed far more active than caffeine itself.
Scientists finally solved how a common gut bacterium triggers colon cancer
Researchers solved a long-standing mystery behind how a bacterial toxin associated with colorectal cancer damages the colon. The toxin first binds to a receptor called claudin-4, giving it access to attack the cells' protective barrier. After identifying this weak point, the team designed a decoy protein that successfully blocked the toxin in mice. The discovery could pave the way for new therapies to prevent inflammation and colon tumors.
Death of Console Discs Pushes Gamers to PC
The reception of PlayStation's recent decision to stop producing physical games media in early 2028 has been heard far and wide across the internet, with fans even going as far as to start the "Don't Kill the Disc" petition on Change.org. More recently, a survey on Push Square, a publication that...
GLP-1 drugs linked to long-term benefits for PAD patients
PAD patients treated with GLP-1 receptor agonists lived longer, stayed out of the hospital more and experienced fewer amputations than those given metformin.
Meet the Preceptors Shaping the Future of Nursing
At the center of our health system’s mission is a commitment to the next generation of healthcare leaders. As the country’s largest municipal health system, we are proud to invest...
Warm here, cold there reception greets go-live of ‘Make Hospital Food Healthier’
HHS reiterates: Consistent with the Code of Federal Regulations and CMS guidance, hospitals “should provide inpatient meals that align with the federal government’s Dietary Guidelines for Americans.”
Turkey's Erdogan hosts NATO summit as political rival Imamoglu defends himself in court
ISTANBUL (AP) — As Turkish President Recep Tayyip Erdogan hosted NATO leaders in Ankara on Wednesday, his main political rival defended himself against corruption charges in court.
This 12-year-old created an AI receptionist to help small businesses
Mana Jampala is a Gen Alpha founder who is already building enterprise tools using ChatGPT and Claude Code.
WATCH: Trump arrives at NATO summit in Turkey, with ceremonial welcome from Erdogan
President Donald Trump arrived in Turkey on Tuesday to attend a NATO summit and was welcomed at a ceremony by Turkish leader Recep Tayyip Erdoğan shortly after.
Escape the Backrooms just got a surprise Nintendo Switch 2 release
After a huge reception on PC, Escape the Backrooms has come to Nintendo Switch 2 out of nowhere - here's the full rundown.
Türkiye’s Foreign Policy Success Is Reshaping Politics at Home
The most significant political consequence of Türkiye’s handling of the 2026 Iran war may not be what it achieved abroad, but how it continues to reshape politics at home. President Recep Tayyip Erdogan emerged from the crisis with enhanced regional standing after Ankara helped facilitate de-escalation efforts while maintaining relations across competing camps. At a time when the Middle East… Continue reading Türkiye’s Foreign Policy Success Is Reshaping Politics at Home
FSU Health nurse practitioner arrested on drug fraud, falsifying medical records charges
A Tallahassee-based nurse practitioner is accused of obtaining prescription medications by prescribing them to her receptionists for her to pick up.
Trump's ties to Erdogan sold him on this year's NATO summit. Turkey may win big in other ways
U.S. President Donald Trump has berated and belittled many of the European leaders expected to attend next week’s NATO summit in Turkey but has only praise for its host, Turkish President Recep Tayyip Erdogan
Trinity Health System School of Medical Laboratory Science celebrates 2026 graduates
STEUBENVILLE — The Trinity Health System School of Medical Laboratory Science graduated its seventh class, comprised of Aliyah Pattie and Audrey Poole. The graduation ceremony was held in the chapel at Trinity Medical Center West, followed by a reception in the Sullivan Room. Trinity’s Medical Laboratory Science program spans 11 months and is designed for […]
I fly the American flag because no political faction owns patriotism
'As a former Superior Court judge, I swore to support and defend the constitutions of the United States and California against all enemies, foreign and domestic. That is a precept all should embrace and celebrate, flag or no flag,' writes an L.A. Times reader.
ArtBeat: Spotlight on the local arts events and entertainment
Here’s a closer look at what you can expect from the area’s events: July 3 First Friday Reception: The Downtown Art Market Gallery in Knoxville invites the community to its First Friday Reception from 5:30 to 9:00 p.m. July’s featured artist is Lynnda Tennpenny, who will showcase a collection of mixed-media artwork. Admission is free, […]
Can GLP-1 medications improve health in people with Type 2 diabetes and PAD?
Research Highlights: GLP-1RA (glucagon-like peptide-1 receptor agonist) medications, which are prescribed to treat Type 2 diabetes and to help with weight loss, were found to reduce the number of deaths, amputations and hospitalizations among people...
South Coast Business & Technology Awards help fund opportunities
SANTA BARBARA, Calif. (KEYT) The networking reception and the South Coast Business & Technology Awards at the Hilton Santa Barbara Beachfront Resort
Roundup: Oil shock / AI receptionists / Warsh’s style
‘Baked-in’ damage: Even though the Strait of Hormuz has reopened in principle, analysts say the economic damage from the earlier disruption is already largely “baked in,” since supply chains, inventories and energy markets have already adjusted to shortages and higher costs. Oil prices have eased from their peak, but inflation pressures are expected to persist […]
Your Business Should Hire an AI Receptionist. Here’s How Quickly They Can Pay for Themselves
AI receptionists can catch missed bookings, answer questions, and free up employees to focus on customers.
Patriots seeing growth from second-year wide receivers
Kyle Williams and Efton Chism each ended minicamp with touchdown receptions.
Turkey's Erdogan Is Running Out of Tricks
"The latest maneuvers of President Recep Tayyip Erdogan of Turkey signal that he has no plans to quietly exit the political stage," writes Ian Bremmer.
Equip Exposition dials up fun with three nights of epic entertainment
The 2026 entertainment line-up features three nights of back-to-back concerts, receptions, and parties, including a new Thursday evening block party at Louisville’s Paristown Point.
Equip Expo adds new Paristown block party to its 2026 entertainment lineup
Entertainment includes a Welcome Reception at Churchill Downs, a Fourth Street Live concert with The Crashers and a new Paristown Block Party.