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Andrews on 'special group', Schade's form and Chelsea

Brentford boss Keith Andrews has been speaking to the media before Friday's Premier League game against Chelsea at The Gtech Community Stadium (20:00 BST). Mathias Jensen, Nathan Collins, Sepp van den Berg and Josh DaSilva will miss the game but they are targeting a return after the international break, while there are no new injuries to report.

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Sep 17 • 10:00 AM EDT • Sports • sports.yahoo.com
Mercy Health launches plan to boost healthcare access in Clark, Champaign counties

Mercy Health – Springfield has launched a new three-year plan targeting four major drivers of local health in Clark and Champaign counties: healthcare access, chronic disease, health behaviors, and social conditions.

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Sep 17 • 5:30 AM EDT • Health • springfieldnewssun.com
Tennessee Secretary of State warns of bogus mail scam targeting newly formed businesses

Tennessee Secretary of State Tre Hargett is warning new business owners not to pay a bogus, overpriced fee to an entity calling itself the Business Resource Center.

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Sep 16 • 2:08 PM EDT • Business • actionnews5.com
Tennessee Secretary of State warns of bogus mail scam targeting newly formed businesses

Tennessee Secretary of State Tre Hargett is warning new business owners not to pay a bogus, overpriced fee to an entity calling itself the Business Resource Center.

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Sep 16 • 2:08 PM EDT • Business • wvlt.tv
Will ExxonMobil's Guyana & Permian Assets Power Its Upstream Business?

XOM is expanding low-cost production in Guyana and the Permian Basin, targeting 5.5 MMBoe/d of upstream output by 2030 as advantaged assets grow.

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Sep 16 • 11:06 AM EDT • Business • finance.yahoo.com
Tennessee secretary of state warns of mail scheme targeting new businesses

A new warning is out for business owners in Tennessee about suspicious mail hitting their mailboxes.

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Sep 16 • 10:53 AM EDT • Business • newschannel9.com
Tennessee secretary of state warns of mail scheme targeting new businesses

A new warning is out for business owners in Tennessee about suspicious mail hitting their mailboxes.

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Sep 16 • 10:53 AM EDT • Business • fox17.com
BTR nears transition to an independent airport authority

The Baton Rouge Metropolitan Airport is targeting the end of October to complete its transition from city-parish governance to a stand-alone airport authority. That’s according to Louis Hubbard I… Already an INSIDER? Sign in. Already an INSIDER? Sign in

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Sep 16 • 10:21 AM EDT • Business • businessreport.com
Globavend Expands from Digital to Live Entertainment with K-Pop Star OK TAECYEON’s Macau Fan Meeting, Targeting US$5.97 Billion Southeast Asian Market

Sold-out MAMAMOO Hong Kong concert supports Globavend’s horizontal expansion into live events; Southeast Asian live entertainment market projected to reach US$10 billion by 2034PERTH, Australia, Sept. 16, 2026 (GLOBE NEWSWIRE) -- via IBN -- Globavend Holdings Limited (NASDAQ: GVH) (“Globavend” or the “Company”), an emerging AI-powered digital entertainment company and e-commerce logistics provider, today announced the expansion of its digital entertainment platform into the live entertainment bu

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Sep 16 • 8:00 AM EDT • Entertainment • finance.yahoo.com
Ukrainian defence tech seeks new ways to scale up

Since Russia's full-scale invasion in February 2022, Ukraine's defence sector has expanded several-fold, becoming a significant source of military innovation, especially in unmanned systems, counter-drone technologies, electronic warfare and AI-driven combat systems. But finding the funds and personnel to scale up and to reach international markets remains a challenge.Spurred on by the demands of the front-line, Ukrainian defence companies say they can develop a minor component in a couple of weeks, or major hardware or software solutions within a year. This is several times faster than the usual development cycles in the sector. Tencore, founded in 2024, is now one of Ukraine’s largest providers of unmanned ground vehicles, well exceeding the production of NATO members in this category. Odd Systems, a Ukrainian combat cameras developer founded in 2023, launched its first thermal camera in 2024. Less than two years later, it is developing the fourth generation of the product, one that has evolved into a full vision system.According to Michael Singer, managing partner at Verne Capital, a venture capital fund supporting defence companies in Europe, this speed is down to the short feedback loop between the developer and the end user. “Ukrainian companies develop technologies in close interaction with soldiers and military units, test them under real combat conditions and rapidly incorporate feedback into the next generation of the product,” he says. “Sometimes we need to react to feedback and deploy an upgrade within hours,” says Polina Tymchenko, the spokesperson for Himera, which develops electronic warfare-resistant walkie-talkies. “It means that, as a company, you have to have a higher tolerance for risk, and also design your products in a way that fosters those quick changes.”Getting a product deployed by a combat command involves no paperwork other than a purchase order, says Perry Boyle, co-founder and chief executive of Mits Capital, a Ukrainian-US investment group focused on attracting capital for Ukraine's defence tech sector. “New weapons can be developed and deployed based largely on handshakes.”Nevertheless, the speed of development is largely subject to the level of funding, says Iryna Sukhomlyn, head of business development at RMachine, a developer of unmanned ground systems. “Financial support needs to start much earlier, particularly at technology readiness level 3-5, not only when most of the technological risk has already been removed,” she says.In 2025, Ukrainian defence tech companies attracted about $129 million in investment, with the true figure likely higher given the share of undisclosed security-sensitive deals, according to a report published by the Kyiv School of Economics. These investments were primarily concentrated in the AI and software segment, as they are considered a lower financial risk.Scaling production is a major barrierAccording to Iryna Supruniuk, business development director at Odd Systems, proving a defence product in Ukraine is not the end of the development process, but the beginning of a continuous evolution, since operational requirements change rapidly. “Continuous iteration remains our highest priority,” she says.It's also when production must scale up, which represents a major hurdle. “Scaling production requires capital, manufacturing capacity, components, certification, procurement access and reliable supply chains,” Singer says. Scale-up is also hampered by demographic pressures, especially a shortage of young specialists needed to expand engineering teams. Companies have reported struggling to replace specialists lost due to Russian attacks, mobilisation and emigration. In order to meet this scale-up challenge and finance arms production, begun allowing defence technologies to be exported, assuming it has an excess capacity. It has also announced the creation of ten defence and weapons export centres across Europe by the end of 2026.According to Singer, a technology that has demonstrated its value under real combat conditions has a fundamentally different credibility than a product that has only been tested in a laboratory or training environment. But combat validation alone doesn’t automatically create an international business. “Companies still need access to foreign defence ministries and procurement organisations, international certification, financing for production scale-up and, in many cases, local industrial partners,” he says.Already in 2026, the EU has signed several agreements with Ukraine that aim at joint defence technology development and production. These include allowing Ukraine to join the European Defence Fund, signing a financing agreement under the European Defence Industry Programme, and setting up the EU-Ukraine Drone Alliance.For Singer, it is important that European defence companies don’t just see their Ukrainian partners as technology suppliers, but rather as potential innovation partners. “Ukrainian companies bring speed, operational experience and an exceptional ability to iterate. European partners can provide industrial capacity, capital, established supply chains and access to European procurement markets.”Procurement possibilitiesWhen it comes to exports, the procurement and compliance processes involved require time, taking months or even years, and money. In other words, resources that small defence tech companies need if they are to improve and scale up their technologies. According to Sukhomlyn of RMachine, if the priority is to rapidly increase available defence capabilities, then the processes need to reflect that urgency. “If Europe wants defence innovation at wartime speed, its administrative processes also need to operate much closer to wartime speed,” she says, highlighting a need for support with certification, market access and mutual recognition of relevant testing. “Otherwise, we risk having excellent technology available but spending years making it administratively eligible to be purchased.”Related articlesRussia widens targeting of European research centresEU must support research managers in central and eastern Europe, says Visegrad fund headThis is a lesson Europe’s defence sector would do well to learn, Singer says. “Defence innovation needs to be organised around the speed and requirements of the end user, not around the speed of the bureaucracy.”Supruniuk says the European defence sector should rethink the balance between quality and quantity. “In many cases, a good-enough system available in thousands of units creates greater operational value than a perfect system available in dozens.”“For decades, everyone has been looking for that all-powerful, exquisite system that can protect everyone,” adds Tymchenko. “We see in crime that only scalable, dedicated, affordable solutions can actually defend democracies.”

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Sep 16 • 8:00 AM EDT • Science • sciencebusiness.net
EU membership bid gives boost to Moldova’s fledgling R&D landscape

Moldova’s push to join the EU is having the spillover effect of helping to improve the country’s R&D landscape, which in recent years has suffered from fragmentation, decreasing personnel and a lack of research infrastructure.The country became an EU candidate country in 2022, alongside Ukraine, and officially began accession negotiations in 2024. With a pro-EU government, Moldova has been actively carrying out reforms to align with EU standards. This has helped accelerate the development of R&D, said Igor Chiosa, acting head of the Research and Innovation Policy Directorate at Moldova’s Ministry of Education and Research. “Our R&D landscape is moving up, and we are more and more involved in the European Research Area,” he said. “The support we receive from the EU is very important, not only financially, but also because of incentives, consultation and capacity building.”The R&D landscape in the former Soviet republic is still relatively underdeveloped, despite attempts at improvement going back to a 2004 law on science and innovation and later reforms in 2017 and 2018. But the system remains in a “precarious situation” and “in the process of contraction,” according to an assessment carried out by the government for the current National Programme for Research and Innovation, which runs from 2024 to 2027. The analysis highlights in particular the declining number of researchers and PhDs, which has been continuously falling, as well as limited research funding. This is around 10 times lower than the EU average and “insufficient to maintain a level of research activity that supports higher education and meets the needs of the economy.” The mechanisms for allocating research funds are also described as inefficient, as well as the general fragmentation of the landscape, with research and innovation activities being carried out in 67 different places. The lack of strategic vision for research infrastructure is also noted. The strategy sets out to address these issues and is being fuelled by reforms linked to EU accession. Moldova now has a regulation on open science and gender equality. There is also a new support mechanism for technology transfer offices and a business-academia roadmap. In 2025, the country also became the first Eastern Partnership country to approve a Smart Specialisation strategy, which will coordinate its R&D efforts to focus on strengths, within a European context. “We’ve done a lot in terms of normative acts,” Chiosa said. Horizon Europe successMoldova is also seeing more success in the EU’s flagship R&D programme, Horizon Europe. The country has now won nearly €15 million in funding, already double the amount won under the previous programme, Horizon 2020, and more than the €10 million target set by the government. Chiosa said the priority has shifted now to winning more research-centred projects, rather than those related to support and capacity. Moldova is also targeting further involvement in large European projects. Last year, it joined the EuroHPC Joint Undertaking giving Moldovans access to Europe's supercomputing network. The country is also a member of Danubius-RI, a European research infrastructure focused on river and sea research. Despite these efforts, Moldova’s research capacity is still shackled by its limited R&D budget, which equates to 0.23% of its GDP. This is around half of what its neighbour Romania spends, which is the lowest in the EU. According to Chiosa, the research budget is increasing year-on-year, jumping by €6.34 million between 2024 and 2025. But this doesn’t show up when looking at it as a proportion of GDP. “Of course, it’s difficult,” he said. “That is why we are putting more emphasis on collaboration between business and academia, as well as participation in Horizon Europe, to try to diversify our sources of funding.”A World Bank loan of €30 million, plus a grant of €7.8 million, was agreed in 2025 to support the modernisation of Moldova’s universities. As part of this, a call was launched this year to provide universities grants of up to €900,000 to develop their research infrastructure. Moldova is also collaborating closely with Romania, with which it shares a common language, funding 100 joint projects in 2023 and 2024. This support has been instrumental. “They are helping with sharing their expertise, inviting us into consortia, and lots more,” Chiosa said. Looking forward, Moldova is eagerly anticipating joining the EU. “We are looking closely at what the EU is doing and will shape our future national programme in research innovation accordingly.”EU accession “blocked at a technical level”Moldova is aiming to join the EU by 2028, but despite its swift and eager efforts to meet the accession criteria, there remain obstacles outside of the country’s control. For a country to join the EU, it must have certain legislation in place and meet specific standards in various areas. This is categorised into six thematic clusters containing 33 chapters. Moldova and the EU have so far opened two of the clusters, numbers one and six. The first covers fundamental laws, such as the judiciary, security and financial legislation. The sixth covers external relations. The remaining four clusters are still unopened. This includes the third cluster, on competitiveness and growth, which contains the chapter on science and research.Related articlesQ&A: Albania’s ambition to become a ‘moderate innovator’Data corner: Horizon success rates are droppingThe European Commission has confirmed that these clusters are ready to be opened, with an official saying that the Commission is encouraging EU governments, who have the final say, to move forward on the matter. However, both clusters two and three remain blocked by the EU Council’s working party on enlargement and countries negotiating accession to the EU, a different official, representing the Council, confirmed.This working party is set to meet several times in the coming weeks, with a Council meeting scheduled for mid-October in which enlargement, and Moldova’s bid, will be discussed. But there is no certainty that these talks will lead to progress. According to the Council source, it is “completely impossible to foresee if and when the file will be unblocked,” citing the sensitivity of the matter. Moldova’s situation is particularly complicated. One factor is that it borders Ukraine and is increasingly embroiled in Russia’s war, with drone incursions occurring more often on its territory. Another is Transnistria, a Russian-backed breakaway state that lies within the territory of Moldova. It is unclear how the EU would be able to accept Moldova into the bloc while this situation remains unchanged. While there is no direct reason to delay opening cluster three with Moldova, as it covers matters unrelated to security, it could be that the EU is reluctant to speed through accession negotiations without first resolving broader, geopolitical issues.Chiosa is confident that, if and when the chapter on science and research is opened, Moldova will be able to finalise it quickly. It doesn’t require any legislative changes and is only a matter of proving certain standards, which Chiosa believes Moldova is well prepared to do. “We hope that chapter 25 on science and research will be one of the first chapters opened and closed,” he said.

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Sep 16 • 8:00 AM EDT • Science • sciencebusiness.net
Former OpenAI executive Fidji Simo joins Nscale board as company prepares for U.S. IPO

Fidji Simo joins Nscale's board as the London-based AI infrastructure company prepares for a U.S. IPO targeting up to $3 billion.

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Sep 16 • 7:39 AM EDT • Business • bizjournals.com
Rubio announces new visa restrictions targeting South African officials for ‘race-based discrimination’

US Secretary of State Marco Rubio announced a new policy to restrict visas from South African officials alleged to be involved in “race-based discrimination” and “uncompensated land seizures.”

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Sep 15 • 6:00 PM EDT • Politics • cnn.com
Scientists Resurrect 160-Million-Year-Old Molecules With Surprising Power Against Superbugs

Ancient mammalian antimicrobial peptides revealed stronger bacteria-killing activity in some cases, offering clues for designing future treatments against resistant infections. Some proteins that vanished millions of years ago may still have something to teach scientists about fighting modern infections. University of Oregon biologists have reconstructed antimicrobial molecules dating back as far as 160 million years,

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Sep 13 • 5:44 PM EDT • Science • scitechdaily.com
Trump demands Ukraine halt refinery strikes as diesel surges

President Donald Trump said he’d warned Ukrainian President Volodymyr Zelenskyy to stop targeting oil refineries in Russia amid strikes that have shut down diesel refining and helped drive prices for

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Sep 13 • 1:03 PM EDT • Entertainment • thederrick.com
Diablo 5 to Release in 2029 From Blizzard

"Diablo 5" is in development at Xbox's Blizzard Entertainment. The game is targeting a 2029 release date.

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Sep 12 • 2:23 PM EDT • Entertainment • variety.com
How burnt coconut helped discover new to science endemic species in Sri Lanka

COLOMBO — As dusk settled over the paddy fields at Puwakpitiya, a village on the northern edge of Knuckles Mountain Range locally known as Dumbara mountains in Central Sri Lanka, researchers began laying traps along the uneasy boundary between farmland and forest. They were targeting small terrestrial mammals moving through the landscape. On the ground, […]

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Sep 12 • 10:13 AM EDT • Science • news.mongabay.com
St. Louis aldermen pass sweeping business bills targeting data centers and food trucks
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Sep 11 • 7:00 PM EDT • Business • ksdk.com
Republicans made El-Sayed a top midterm target. The Democrat wants to talk about Michigan voters

Republicans are aggressively targeting Abdul El-Sayed, the Democratic Senate nominee from Michigan, as the face of the opposition.

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Sep 11 • 6:44 PM EDT • Politics • clickorlando.com
😐 Neutral (16%)
Republicans made El-Sayed a top midterm target. The Democrat wants to talk about Michigan voters

Republicans are aggressively targeting Abdul El-Sayed, the Democratic Senate nominee from Michigan, as the face of the opposition.

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Sep 11 • 6:44 PM EDT • Politics • news4jax.com
😐 Neutral (16%)
Posts touting mebendazole as cancer treatment go beyond the science

The anti-parasitic drug mebendazole has shown preclinical efficacy in targeting multiple cancers, but experts say social media posts calling it a "cure" go too far. Additional clinical trials in humans are necessary to prove when, at what dosage, and in which treatment combinations it could make an impact.

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Sep 11 • 5:09 PM EDT • Science • factcheck.afp.com
Posts touting mebendazole as cancer treatment go beyond the science

The anti-parasitic drug mebendazole has shown preclinical efficacy in targeting multiple cancers, but experts say social media posts calling it a "cure" go too far. Additional clinical trials in human...

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Sep 11 • 5:09 PM EDT • Science • yahoo.com
Senior House leader to talk about Republicans targeting ‘communism’ in midterms

Conference chairwoman Lisa McClain will focus on Democratic policies, including those on immigration.

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Sep 10 • 4:37 PM EDT • Politics • washingtonpost.com
Anthropic posted, then deleted, a $450,000 sales job aimed at Meta

Anthropic listed a sales job specifically targeting Meta, a major customer but also a rival in the AI race. It has since deleted the posting.

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Sep 9 • 7:22 PM EDT • Business • businessinsider.com
🙂 Positive (50%)
Private Equity’s Next Focus: Profitable Niche Businesses

After years of targeting industries like veterinary practices and plumbing companies, experts say private equity is focusing on more profitable niche businesses.

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Sep 9 • 2:50 PM EDT • Business • forbes.com
See rally for CA bills targeting corporate profits for immigrant detention
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Sep 8 • 9:23 PM EDT • Politics • sacbee.com
University of Chicago health care workers push for passage of RIFL Act targeting gun manufacturers
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Sep 8 • 5:49 PM EDT • Health • cbsnews.com
High-Signal Publisher
Hackers breach F5 BIG-IP APM devices to deploy Linux rootkit

A Linux rootkit targeting devices in F5 BIG-IP APM environments can intercept PHP file loading and inject a fileless web shell directly into memory, avoiding the need to write malicious code to disk.

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Sep 8 • 4:08 PM EDT • Technology • bleepingcomputer.com
Why a cannabis business is betting on dogs to reach FDA approval

Endovia is pursuing FDA veterinary approval for its cannabinoid drug targeting canine cancer and chronic pain in the companion-animal market.

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Sep 8 • 9:28 AM EDT • Business • mjbizdaily.com
How 2026 candidates are targeting health care "corruption"

They're accusing opponents of being in the pockets of drugmakers or health insurers.

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Sep 8 • 5:30 AM EDT • Health • axios.com
High-Signal Publisher
From TV to TikTok: Social media is reshaping political campaigns

Luke Bronin’s upset of John Larson highlights how Connecticut campaigns are using social media, short-form video and digital targeting to reach voters.

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Sep 7 • 4:00 AM EDT • Business • hartfordbusiness.com
From TV to TikTok: Social media is reshaping political campaigns

Luke Bronin’s upset of John Larson highlights how Connecticut campaigns are using social media, short-form video and digital targeting to reach voters.

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Sep 7 • 4:00 AM EDT • Politics • hartfordbusiness.com
One Million Moms warns parents against Disney's 'Coven Academy' targeting kids

Conservative advocacy group One Million Moms is warning parents about Disney s upcoming series Coven Academy, saying it pushes witchcraft on children and teenagers The PG-V series premieres Oct 1 on

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Sep 6 • 11:36 PM EDT • Entertainment • christianpost.com
Scientists find a weak spot in one of the deadliest brain cancers

Researchers may have found a new way to weaken glioblastoma’s defenses against treatment. Blocking a protein called SET prevented tumors from forming in preclinical models, while targeting related proteins made cancer cells more vulnerable to radiation. The strategy works by restoring activity of PP2A, an enzyme that glioblastoma cells appear to suppress. Human testing will be needed to determine whether the approach is safe and effective.

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Sep 5 • 8:00 PM EDT • Science • sciencedaily.com
Why the new Trump order to shoot wolves is both illegal and a dreadful precedent for endangered species

On September 4, Donald Trump issued an executive order targeting the Endangered Species Act (ESA) protections of gray wolves and Mexican gray wolves. In the Oval Office he stated to an Arizona ranc…

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Sep 5 • 4:54 PM EDT • Science • southernfriedscience.com
‘These are real people’: 9 Sacramento businesses targeted within days, 1 arrest made

(FOX40.COM) — Sacramento police arrested 46-year-old Darrell Buckner in connection to five out of nine recent burglaries targeting businesses in midtown and downtown Sacramento. “These …

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Sep 5 • 1:52 AM EDT • Business • fox40.com
Chaucer targets further global growth as business approaches $4 billion

Chaucer is targeting further growth through its overseas offices under a five-year strategy designed to build on its expansion from roughly $1 billion of insurance and reinsurance business ​in 2019-20 to about $3.7 billion to $3.8 billion today.

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Sep 4 • 3:19 AM EDT • Business • theinsurer.com
Health Brief: The remote monitoring squeeze

Plus: Health tech dealmaking spree is spilling into digital health, with buyers targeting virtual care, diagnostics, wearables and AI.

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Sep 3 • 6:48 PM EDT • Health • washingtonpost.com
Judge blocks new Trump bid against birthright citizenship

Maryland judge issues preliminary injunction blocking Trump’s executive order targeting what he termed ‘birth tourism’

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Sep 3 • 6:07 AM EDT • Politics • theguardian.com
Chevron expands Venezuela position, to invest $7 billion in next five years

Chevron said ‌on Wednesday it had agreed with Venezuela on updated ​terms for its joint ​ventures in the country ⁠and plans to invest ​more than $7 billion over ​the next five years, targeting production of about 600,000 bpd.

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Sep 2 • 6:20 AM EDT • Business • reuters.com
August Monthly Review: ChatGPT In Epic

Death, taxes, another frontier lab healthcare launch inspiring truly insane LinkedIn takes. As much as I want to stay away, I repeatedly am the crewman unplugging his ears whenever we pass these sirens. So it’s not the first and probably not the last time we dial up the typewriter rather than tie ourselves to the mast. The full blow-by-blow timeline: Health API Guy is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe The End of the Standalone PHR (Jan 8): ChatGPT Health arrives for consumers, at the time powered by b.well. I was bullish on the approach in that the best way for the PHR to finally solve distribution was to meet consumers were they already are (i.e. When Horizontal Meets Healthcare (Jan 9): OpenAI for Healthcare puts out the shingle for enterprises, with SharePoint ingestion standing in for the EHR integration the product actually needed. Another One: Anthropic’s Healthcare Debut (Jan 16): Claude's version, on HealthEx rails instead of b.well, with Agent Skills for FHIR development as the one true vertical-specific investment. ChatGPT for Clinicians: The Trap Sprung (Apr 24): OpenAI filled in the missing GTM middle with a free product for verified clinicians, effectively peeling the enterprise wrapper off ChatGPT for Healthcare and taking the PLG fight directly to OpenEvidence. OpenAI’s Second Attempt at Health (Jul 31): a relaunch of their patient specific app, now branded Health in ChatGPT, where the privacy partition came out, the connectors thinned, and b.well disappeared in favor of first-party FHIR work against a smaller network Beyond a Shingle So what was announced now? Today, we’re introducing a new electronic health record integration that brings authorized patient context from Epic into ChatGPT for Healthcare, along with the Healthcare Public Data plugin for direct, structured access to official healthcare datasets like PubMed, DailyMed, and CMS Coverage. Together, these capabilities bring ChatGPT closer to the systems and sources healthcare teams trust, while supporting the controls and compliance healthcare work requires. The core portfolio is unchanged from prior announcements we delineated and discussed (aside from the relaunch of patient-facing). Since trade publications still seem to be confusing them by using the wrong names: Enterprise sales motion: ChatGPT for Healthcare Protecting their core product / PLG: ChatGPT for Clinicians Consumer/patient-facing product: Health in ChatGPT So really, this is a feature release (specifically for ChatGPT for Healthcare when it comes to EHR integration). What’s cool about it, though, is that we are moving beyond just putting out a shingle. Everything in the January enterprise launch was horizontalizable: Horizontal tech companies thus generally start verticalization with their “putting out a shingle phase”. Telling the world you’re open for business as a horizontal tech company reliably attracts early inbound interest from buyers who are already trying to force-fit horizontal tools into domain-specific workflows and are eager for any signal that the vendor intends to support their use case more directly. Nothing was really vertical specific, which is exactly what you'd expect from the ultimate hypergrowth horizontal company dipping their toes into specific industries. But eventually you have to stop changing the sign on the door and start changing the product. Can you guess where the horizontal product was going to run out of road? This is the core dilemma writ large: verticalization requires differentiation, while scale economics of consumer and horizontal push toward unification. I’ve buried the lede so deep here it will be painful to some readers, but what should be shocking to no one is that my perspective is that EHR integration is the only path that meaningfully resolves this tension for ChatGPT for Healthcare. Integration with Microsoft Sharepoint is fine, but it is categorically insufficient for any product that hopes to influence clinical decision-making. SMART Money Well here we are, eight months later! Real vertical investment has begun, which surprised a few people. One friend in the industry messaged me: “Absolutely no way Epic gave ChatGPT API access.” Looking forensically at the announcements, the integration is notably read-only across appointment notes, laboratory results, medications, and specialist documentation. So while I’m not a betting man, I'd wager the house this is a SMART on FHIR launch: That sounds a lot like USCDI! The recommended path for the workflow they outline would be SMART on FHIR Their Health AI lead’s post is evocative of both standalone and EHR launch SMART, which another termed “ChartGPT” and “EHR Plugin” The implementation burden for SMART on FHIR is the lowest of the available integrative paths This is the team who literally did patient-facing SMART on FHIR with Epic last month Most importantly, if you’re a horizontal company, you generally still haven’t taken the full plunge and thus (overly) value reusability. SMART on FHIR is the logical compromise: healthcare-specific enough to matter, but standardized enough to reuse. Nobody Asked Judy Another friend asked “I thought they had to go to each health system, or did they go direct to Epic and now health systems opt in?” Given the trust paradigms in healthcare, this functionally cannot be Epic hoovering up all the data for OpenAI and shoving ChatGPT in their customers’ faces (or they would revolt). However, I do believe the aforementioned terrible coverage by TechCrunch and other outlets is probably responsible for that question, given the 325 million reference. When using FHIR as a business associate to an Epic customer, there is no EHR gatekeeping to speak of, as that isn’t how fhir.epic.com works: You register an app You pick your APIs You test against the sandbox APIs You list as “Ready for Production” Hospitals pick your app You test and go live with them Bluntly, nobody had to say yes or no in Verona (nor were they given the chance). Vendor Services (their next developer tier up that I doubt OpenAI is using quite yet in this initial release) certainly has contractual paperwork that some resent, but even there, the twin pressures of mounting antitrust and information blocking make outright gatekeeping increasingly fraught. My friend’s sentiment is, to me, representative of a broader industry neurosis, perhaps a sort of scar tissue of prior eras: people assume the gate is still there and never actually try the door. There are certainly other ways Epic (and any EHR) can put its thumb on the scale, but they are not so dumb as to stand in front of a federally mandated API and play bouncer at this exact moment in time. So I think they can and probably should go deeper, as this release is at best parity and at worst behind vertical-specific competition. OpenEvidence did a basic SMART launch with Sutter Health in February, allowing for more convenient evidence search by providers. They then add patient-context (the equivalent SMART on FHIR flow to what we see here) when Cedars-Sinai went enterprise-wide in May. UpToDate has four distinct applications across deeper workflows like patient engagement listed in Epic Showroom and announced a partnership with Epic to power Art at UGM Abridge and other ambient scribes have invested deeply into the deepest bidirectional clinical copilot workflow with integrations well beyond SMART on FHIR. In that light, the “Who is OpenAI primarily targeting here?” is clear. This release brings them into striking distance of OpenEvidence, but not the others quite yet. They are the only one of the three you can reach without building something truly Epic-specific. When will they go further? Competition is a great motivator to overcome the horizontal demons and start building things that can’t be reused: not across industries, not across EHRs, maybe not past the customer you built them for. That’s the price of actually verticalizing. The question is if and when OpenAI will be willing to pay it. Month in Review Here is the monthly review. As a reminder, this is a regular round-up of the month’s posts and other content to surface things you may have missed across regulation, litigation, interoperability, and beyond. AI assistance is used in these bullet summaries so I can focus on articles. Articles Published: None this month Video Content: The Information Exchange: Standards-based Thruple Edition (Aug 14): Back to school for us too, with Brad reporting in from the CMS Health Tech Ecosystem’s one year anniversary in DC. We get into the January CMS-0057 deadline, the fall rulemaking reading list, and why enrollment still keeps most apps off FHIR. The Information Exchange: Epic Dúnadan Edition (Aug 25): A UGM roundup with Ryan Brickner joining for the first time to check our takes against what the building actually thinks. Rangers, Ergo sitting on top of EHI, and a down-market lineup that needs some cuts. Regulatory: Stacked Deck, Bad Hand (Aug 05): ONC’s website refresh took the entire HIT Policy Committee record with it, so I rebuilt the archive and went looking for the regulatory capture story everyone assumes is buried in there. Stacking the deck and winning the hand turn out to be very different things. The Sixth Generation of Patient Access (Aug 19): A quick catalog of the five generations of patient access we’ve layered on since HIPAA, and the two candidates now competing to be the sixth. One is planned. The other is the market routing around the plan entirely. Court cases: Three Cases Walk Into a Docket (Aug 06): Two surprise settlements cleared the board in a single week, and then Judge Maddox dropped ninety-four pages on Vyne v. Henry Schein. The sleeper is a DMCA holding that makes direct-to-database a considerably riskier business model. Epic v. Health Gorilla: Into the MDL (Aug 10): Nine class actions are headed to Miami, and the Panel signaled it wants to bring the case that spawned them along too. That would leave Epic arguing the requests were obviously fraudulent in one courtroom and unknowable in the other. Amazon v. Perplexity: Agents Are Legalized! (Aug 11): The Ninth Circuit vacated the injunction against Comet, holding that the user is the one accessing the servers rather than the company that built the agent. A real win for agentic access, and a much narrower one than the headline suggests. Veeva v. Epic: Come At Me, Bro (Aug 26): Epic’s response brief wants the dismissal affirmed and, unusually, wants the opinion published as precedent. Buried in it is Epic’s own description of what its non-competes actually prohibit, which current and former employees should read closely. EHRs: The Contract Epic Would Never Sign Today (Aug 04): A 1999 SEC exhibit catches Epic licensing nearly its entire product line, Tapestry included, to the company that became TriZetto. The marketing services menu attached to it is the part that will make you blink. Forecast from Verona (Aug 07): The Epic Almanac makes one argument six different ways: the AI is only as good as the networks behind it. Emmie headlines, Art’s context stack is the most ambitious part, and Penny finally gets an autonomous coding date on the calendar. Works With Epic MyChart (Aug 17): Epic’s first new Showroom category since the death of Workshop certifies hardware instead of software, badge on the box and all. Made for iPhone, but for blood pressure cuffs, and rough news for anyone selling the RPM stack sitting in between. UGM Hot Takes 2026 (Aug 20): Everyone else covered the AI announcements, so I went after Savvy deleting the payment gateway, Rangers as Boost with the timer removed, and a down-market lineup with too many entries. Plus the Health Grid tidbits I cannot help myself on. MyChart Central Grows Up (Aug 24): Device data and Emmie turn Epic’s identity hub into a full consumer platform, which is both a logical answer to ChatGPT and a bit of a mistake. It also happens to be the best scraping target Epic has ever shipped. Industry Analysis: The Wrong Yardstick (Aug 12): Vertical software keeps getting judged against Superhuman and Notion, which is the wrong bar entirely. Your user is comparing your product to a whiteboard and forty phone calls before lunch. Primitives vs. Abstractions (Aug 27): Developers want building blocks, systems of record prefer to hand out business logic, and both sides have a real case. There’s no test from the outside that separates the engineering reason from the competitive one, which is why this keeps ending up in court. Cross-industry Comparisons: The Two Kinds of Platform Power (Aug 18): Attention power and record power are different problems that keep getting handed the same regulatory toolkit. Congress’s latest swing at Big Tech shows both what’s possible and where it falls apart. The Dogs of (Platform) War (Aug 21): A CourtListener alert turned up a property management fight with healthcare’s exact shape and none of the Cures Act. Shell prospects, ghost accounts, a notetaker bot that came back to haunt someone, and a lawyer arguing both sides of the same theory in two states. Fractals All the Way Down (Aug 31): Yardi dominates property management right up until you zoom into one segment, where AppFolio owns it outright and Yardi doesn’t appear at all. Where you draw the line around a B2B software market is about to decide an awful lot of cases. Other News: If Judy Had the Courage (Aug 13): A short eulogy for the era when software was allowed to look insane: WinAMP, bold colors, and everything the grey chatbot era has taken from us. External Media: Portland Monthly Health Tech Meetup: Erin O’Brien channeled my own feelings - maybe it’s just because it’s August and beautiful, but the monthly edition of the PDX Health community meetup was a ripper. Make sure to reach out if interested to join for the next one. STAT’s Coverage of Epic This Month: Brittany Trang of STAT did a fantastic job of breaking the FTC investigation that’s been lurking, as well as UGM related coverage, so I had to give her her wish of a meme. Fall Conferences: I’m pumped to be kicking off my fall conference season in NYC at Nabla Accelerate next month, which Chrissy provided the link to apply for. Here’s the rest of my schedule in case you want to meet up: Commonwell (Redwood Shores, CA): Oct 13-14 Open@Epic (Madison, WI): Oct 21-22 eHealthExchange (Austin, TX): Oct 27 Sequoia Project (Austin, TX): Oct 28-29 HLTH (Vegas): Nov 15-18 RSNA (Chicago): Nov 29-Dec 3 Posts I Liked: HTI-6 Should Unbundle API Certification: Josh Mandel makes the case that HTI-6 should split (g)(10) into separate authorization and data certifications, so a PACS or a genomics platform can certify only the role it actually performs. Imaging is the urgent example, but the structure solves a much bigger problem. On implementing ePrior Auth with Epic: Scott Rossignol’s field notes from a live ePrior Auth build on Epic, including the two app registrations nobody warns you about and the CPT mapping problem waiting at the end. CMS-0057 implementations are going to be such a beast. Healthcare point solutions are starting to look a lot like streaming services: Spencer Dorn runs the cable-to-streaming arc against health IT and lands squarely on the bundling half of the cycle. Bundling can be good! It can also be bad! Life is nuanced. Health API Guy is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe

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Sep 2 • 5:05 AM EDT • Health • healthapiguy.substack.com
Everton targeting Manchester United’s Joshua Zirkzee as Folarin Balogun alternative

Everton are targeting a late move for Manchester United striker Joshua Zirkzee (25), according to a report from L’Équipe. The Toffees have identified the Dutch forward as an alternative to Folarin ...

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Sep 1 • 4:25 PM EDT • Sports • sports.yahoo.com
Baptist Health warns patients of MyChart phishing scam

Baptist Health is warning patients about a widespread phishing scam targeting users of the MyChart medical portal.

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Sep 1 • 8:28 AM EDT • Health • wave3.com
Trump admin shuts down 270 driving schools in fraud crackdown

President Donald Trump's administration continued its nationwide campaign against fraud with new announcements targeting trucking fraud in Detroit.

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Aug 31 • 10:48 AM EDT • Business • foxbusiness.com
Trump’s deals in Africa could cut U.S. health aid by more than half, analysis shows

The planned reductions — targeting programs that combat the spread of deadly diseases — coincide with an administration push to make developing nations spend more.

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Aug 31 • 6:00 AM EDT • Health • washingtonpost.com
NASA’s Roman Space Telescope: Launch Updates

NASA's live online coverage of the launch of the agency's Nancy Grace Roman Space Telescope is underway. NASA and SpaceX are targeting 7:26 a.m. EDT Sunday for liftoff aboard a SpaceX Falcon Heavy rocket from Launch Complex 39A at NASA's Kennedy Space Center in Florida.

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Aug 30 • 6:00 AM EDT • Science • science.nasa.gov
Bengals should consider targeting 3 early NFL cuts

NFL teams have started making cuts and the Bengals might be interested in a few of them.

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Aug 30 • 5:31 AM EDT • Sports • sports.yahoo.com
Canada fights back in US trade war, targeting specific states

Canadian officials say they aim for 'political pressure' on US officials with retaliatory tariffs on imports.

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Aug 29 • 5:04 AM EDT • Politics • usatoday.com
The AI Backlash Is Transforming Into a Political Movement

A new group is targeting tech companies and the government with the climate movement’s playbook.

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Aug 28 • 11:17 AM EDT • Politics • theatlantic.com
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US Treasury imposes limits on Egyptian bank for doing business with Iran

Measures targeting UAE branches of Banque Misr are part of Trump administration’s efforts to isolate Tehran

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Aug 28 • 10:00 AM EDT • Business • ft.com
GTA 6 Targeting 30fps on PS5, Undecided on Performance Mode

Not surprising really

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Aug 27 • 7:30 PM EDT • Technology • pushsquare.com
Exclusive: Meta disrupts Iran-linked AI operation targeting politicians, journalists

Meta takes down Iranian influence operation that used AI

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Aug 27 • 1:00 PM EDT • Politics • axios.com
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Michigan Dem AG turns on El-Sayed over terror attack response, warns of mentality that 'bothers me a lot'

Dana Nessel says Abdul El-Sayed's response to the Temple Israel attack appeared to make excuses for domestic terrorism targeting Jewish worshippers.

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Aug 27 • 10:53 AM EDT • Politics • foxnews.com
Sword Health to acquire Headspace in all-cash deal

Virtual physical therapy platform Sword Health is planning to acquire digital mental health company Headspace in an all-cash deal, according to a regulatory filing from the latter. | The virtual physical therapy and mental health platforms are targeting a September close, per a regulatory filing. A price tag was not disclosed, but is being reported to land between $200 million and $300 million.

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Aug 26 • 12:28 PM EDT • Health • fiercehealthcare.com
Boston Scientific hit by cyberattack causing ‘disruptions’ to parts of its business

This year has seen a growing number of medtechs hit by cyberattacks, and now Boston Scientific has become the latest victim. In an SEC filing posted Aug. 26, the medtech giant said it had detected a “cybersecurity incident” the day before. The incident has affected certain parts of its information technology systems, something that “has resulted in a global disruption to the company’s operations.” The incident has hit not just its information systems but also its business applications, which “support aspects of the Company’s operations,” it said in the filing. This includes its ability to process and ship customer orders. Boston Scientific said it is working to restore the systems, but the timeline remains unknown. Related Baylor Genetics hit by cybersecurity attack targeting patient, staff information As the company investigates the incident, it remains unclear how significantly its business will be affected. “Accordingly, the Company has not yet determined whether the incident is reasonably likely to have a material impact.” The company’s shares were down 3.5% in premarket trading as the news broke. This adds another layer of pressure for the medtech, which last month revealed a new global restructuring program that starts this year and is slated to be completed by 2029. The company said at the time that it “does expect some headcount reductions to result from these restructuring activities,” but did not provide any numbers or specify areas where the cuts may be made. It added, however, that new jobs are also set to be “created in areas of growth.” It was also forced to cut its sales guidance in Q2, saying in late July that it now expects full-year 2026 organic revenue growth of 5% to 6%, down from its previous guidance of 6.5% to 8%. Boston Scientific is one of a growing number of life sciences companies, notably medtechs, that have been hit by cyberattacks this year. These include Abbott, iRhythm, Medtronic and Stryker, as well as Big Pharmas Amgen and Novo Nordisk.

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Aug 26 • 7:26 AM EDT • Business • fiercebiotech.com
Secret Service aware of Iranian video threat targeting Barron Trump, agency says

A video aired on Iranian state media depicts locations tied to Barron Trump and offers a suggested $10 million reward for his exact location.

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Aug 25 • 4:34 PM EDT • Politics • foxnews.com
Pritzker’s swagger stunt backfires as critics roast viral video: ‘Cringiest thing he’s ever posted’

Illinois Gov. JB Pritzker's black-and-white "aura-farming" video drew widespread mockery on social media, with critics targeting his weight and taxes.

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Aug 25 • 3:31 PM EDT • Politics • foxnews.com
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Outgoing House Democrat Al Green files another impeachment resolution targeting President Donald Trump

Democratic Rep. Al Green of Texas, who lost a Democratic primary runoff earlier this year, filed a new resolution targeting President Donald Trump for impeachment.

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Aug 25 • 9:15 AM EDT • Politics • foxnews.com
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Nikita Bier charges $15,000 for business advice on Intro

Nikita Bier, former X head of product, offers $15,000 business advice sessions on Intro, targeting venture-backed companies.

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Aug 25 • 7:51 AM EDT • Business • businessinsider.com
Health systems warn of coordinated phishing targeting Epic’s patient portal

It isn’t clear how many scammers are involved in the effort, but health systems across the country are warning their patients to ignore fake messages, many of which offer a “reward” in the form of a “MyChart Medicare Kit.”

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Aug 25 • 1:29 AM EDT • Health • healthexec.com
What Trump’s Supreme Court win means for mail ballots

The Supreme Court on Monday permitted President Donald Trump to move forward with a controversial executive order targeting mail ballots, but the decision will almost certainly not be the final word in whether the administration can actually implement its far-reaching plan.

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Aug 24 • 9:08 PM EDT • Politics • cnn.com
U.S. set for largest mass visa revocation in history targeting up to 200,000 foreigners, officials say

The Trump administration is preparing to revoke the visas of up to 200,000 foreigners who have applied for or are currently seeking asylum status in the United States.

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Aug 24 • 4:59 PM EDT • Politics • pbs.org
US aims for ‘economic asphyxiation’ of Iranian regime with new wave of secondary sanctions

Treasury Secretary Scott Bessent launches Operation Economic Outcast, targeting Iran's economy with secondary sanctions to cut off global trade revenue.

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Aug 24 • 2:22 PM EDT • Business • foxbusiness.com
CD Projekt Red is "targeting" a 2028 release date for The Witcher 4, per a new update from the developer

Move over, Songs of the Past - there's a new Witcher news byte in town.

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Aug 24 • 12:05 PM EDT • Technology • eurogamer.net
The Witcher 4 Confirmed for 2028 Release in Official CD Projekt Gamescom 2026 Announcement

The Witcher 4 is targeting a 2028 release window, CD Projekt has confirmed.

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Aug 24 • 11:33 AM EDT • Technology • ign.com
Democratic U.S. Rep. Hillary Scholten blasts Hasan Piker for targeting Moss

Rep. Hillary Scholten said Hasan Piker's rhetoric \

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Aug 24 • 11:20 AM EDT • Politics • detroitnews.com
Centralia Police warn businesses after gift card scam attempt

Centralia police are warning local businesses about a scam after officers were notified Saturday night of an incident targeting a business in town.Police said s

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Aug 23 • 4:23 PM EDT • Business • krcgtv.com
Co-Host of Side Dish, Headkrack with the latest in entertainment headlines

Scammers are targeting celebrity podcasts in a new elaborate ruse. Plus Cosmopolitan has a new trend with some funny candidates.

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Aug 20 • 11:18 AM EDT • Entertainment • fox5atlanta.com
NEWS: Pressley, Ramirez, McGovern Demand Answers of Trump Admin. on Persecution of Political Dissent, Targeting of Left-leaning Political Groups

“Defining political opposition as an existential threat does not make communities safer—it degrades civil liberties, expands state surveillance, enables violence...

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Aug 19 • 3:09 PM EDT • Politics • pressley.house.gov
Whistleblower alleges political pressure, lack of evidence in antisemitism probes targeting schools

The complaint alleges that the investigations into some of the nation’s most prestigious academic institutions were designed to strong-arm the schools into cutting deals for political purposes.

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Aug 18 • 6:48 PM EDT • Politics • nbcnews.com
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Whistleblower alleges political pressure, lack of evidence in antisemitism probes targeting schools

A whistleblower is alleging that a Trump administration task force created to combat antisemitism pushed for settlements with Ivy League universities. That's despite government investigations the...

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Aug 18 • 6:08 PM EDT • Politics • dallasnews.com
States accuse Meta of targeting children for Facebook, Instagram addiction: 'The young ones are the best ones'

Meta faces a landmark federal trial as 29 states accuse the social media giant of exploiting teen addiction on Facebook and Instagram for profit.

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Aug 18 • 1:59 PM EDT • Business • foxbusiness.com
Mr. Gatti’s Pizza targeting return to Lubbock with new Family Entertainment Center

Mr. Gatti’s Pizza is targeting Lubbock as a potential spot for one of its new Family Entertainment Center locations.

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Aug 18 • 10:13 AM EDT • Entertainment • kcbd.com
Mr. Gatti’s Pizza targeting return to Lubbock with new Family Entertainment Center

Mr. Gatti’s Pizza is targeting Lubbock as a potential spot for one of its new Family Entertainment Center locations.

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Aug 18 • 10:13 AM EDT • Entertainment • fox34.com
Whistleblower alleges political pressure, lack of evidence in antisemitism probes targeting schools

WASHINGTON (AP) — A Trump administration task force created to combat antisemitism pushed for settlements with Ivy League universities despite government investigations that were rushed and incomplete or that failed to establish legal violations by the schools, a former Justice Department lawyer ...

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Aug 18 • 9:03 AM EDT • Politics • wral.com
Black Legislative Caucus warns of potential lawsuit from governor's executive order

Members of the Indiana Black Legislative Caucus say Gov. Mike Braun overstepped his authority and risked a lawsuit when he issued an executive order last month targeting a state diversity program.

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Aug 18 • 5:00 AM EDT • Business • indianacapitalchronicle.com
Scientists reveal why walking gets so much harder with age

As we age, the body appears to sacrifice walking efficiency in exchange for stability. Older adults stiffen the ankle more with each step, which may help prevent falls but also forces the muscles to work harder while producing less forward motion. This leads to shorter strides, slower walking, and faster fatigue. Exercises targeting balance, coordination, and lower-leg strength could help preserve mobility.

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Aug 15 • 8:00 PM EDT • Science • sciencedaily.com
Israeli Strikes in Lebanon Kill 9, Health Officials Say

The Lebanese health ministry said several children were killed in a strike overnight, one of the deadliest attacks in months. Israel’s military said it was targeting Hezbollah infrastructure.

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Aug 15 • 7:00 AM EDT • Health • nytimes.com
Premier League: Why clubs are targeting EFL academy players

Premier League clubs are continuing to recruit young players from EFL and Scottish academies for their U21 and B-team squads.

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Aug 15 • 3:16 AM EDT • Sports • bbc.com
Scientists solve the mystery of a brain “switch” that can trigger weight loss in opposite ways

Scientists have uncovered why two seemingly opposite ways of targeting the same brain receptor can both promote weight loss. In mice, activating the GIP receptor in the brainstem reduced appetite, while blocking it in the hypothalamus removed a kind of “brake” on fullness signals. The discovery helps explain why very different obesity drugs can achieve similar results and suggests that carefully combining GIP-targeting treatments with GLP-1 drugs like those related to Wegovy and Ozempic could produce stronger effects.

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Aug 14 • 8:00 PM EDT • Science • sciencedaily.com
Son of former Mexican president challenges Trump after visa revoked

Andrés Manuel López Beltrán — son of former Mexican President Andrés Manuel López Obrador — said the U.S. has revoked his visa, accusing President Trump’s top diplomats of politically targeting him…

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Aug 14 • 3:16 PM EDT • Politics • thehill.com
If Apple sends you a push notification alerting you to a spyware attack, take it seriously

Apple now sends out push notifications to iPhone lock screens when the company identifies government spyware targeting someone's devices.

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Aug 13 • 5:50 PM EDT • Technology • techcrunch.com
Crimson Desert dev comments on status of Nintendo Switch 2 port, targeting first half of 2027

Pearl Abyss has commented again on the Nintendo Switch 2 port of Crimson Desert, providing the most encouraging update we’ve had thus far. In its latest earnings letter, the company said that it’s now “currently playable at a foundational level, and technical evaluations are underway to ensure performance optimization and compliance with our quality standards.” The other piece of important...

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Aug 11 • 6:40 PM EDT • Technology • nintendoeverything.com
Trump set to sign executive order targeting childhood vaccines

President Donald Trump will sign an executive order on Monday focused on childhood vaccines, according to White House press secretary Karoline Leavitt.

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Aug 10 • 2:19 PM EDT • Politics • cnn.com
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Johnson turns Democrats’ socialist civil war into new weapon for midterms

House Republicans launch "Contrast for America" website targeting DSA-linked Democrats, echoing the 1994 "Contract with America" midterm strategy.

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Aug 10 • 9:28 AM EDT • Politics • foxnews.com
AbCellera women’s health data top ‘most aggressive upside scenario,’ putting Astellas and Bayer on notice

AbCellera has reported phase 2 results “beyond even the most aggressive upside scenario” that its CEO dared to consider, boosting the biotech’s chances of challenging Astellas and Bayer for a women’s health market. The phase 2 clinical trial compared ABCL635, an antibody targeting NK3R, to placebo in patients with hot flashes caused by menopause. Investigators enrolled 92 postmenopausal women experiencing a mean of about 10 moderate or severe hot flashes per day. By Week 4, the number of moderate or severe hot flashes had fallen by a mean of 8.8 on ABCL635 and by 3.5 on placebo. That statistically significant, placebo-adjusted reduction of 5.3 hit the trial’s primary endpoint. The level of efficacy also cleared the bar set by existing drugs. While cross-trial comparisons can be misleading, AbCellera CEO Carl Hansen, Ph.D., had seen enough to start hyping the program. “We now view ABCL635 as a potential best-in-class non-hormonal therapy with strong differentiation against approved NK3R competitors across all important dimensions, including efficacy, safety, dosing and convenience,” Hansen said on a Monday morning conference call with investors to discuss the data. “We believe ABCL635 is now a highly de-risked program.” Last week, Hansen used AbCellera’s earnings call to set expectations for readout, with the CEO defining success as a clean safety profile and efficacy comparable to the two approved small molecules. The data vaulted over that bar. Astellas linked (PDF) one of the small molecules, Veozah, to placebo-adjusted reductions in hot flash frequency of 2.1 and 2.6 at Week 4 of its two phase 3 trials. Bayer reported (PDF) placebo-adjusted reductions of 3.04 and 3.29 at Week 4 of pivotal studies for its small molecule, Lynkuet. At 5.3, the placebo-adjusted reduction in AbCellera’s trial comfortably cleared the standard set by the incumbents. Veozah and Lynkuet came to market based on evidence of their ability to reduce the frequency and severity of hot flashes. AbCellera’s phase 2 study covered both endpoints, with the Canadian biotech reporting a mean reduction in severity of 1.4 points at Week 4 on ABCL635, compared to 0.3 points for placebo. Again, the placebo-adjusted result compares favorably to data on Veozah and Lynkuet. Analysts shared Hansen’s enthusiasm for the data. The phase 2 results “firmly validate ABCL635 as a potentially best-in-class treatment,” BMO Capital Markets analysts said in a note to investors Monday. ABCL635’s apparent efficacy edge “is likely attributable to the higher dosing/target engagement the asset is able to reach vs. the oral agents due to its wider therapeutic index,” the analysts added. The analysts, who model $2.3 billion in unadjusted peak sales for ABCL635, flagged the safety profile as another positive of the phase 2 readout. While Veozah carries a boxed warning for liver damage, nobody on ABCL635 in the phase 2 trial had elevated liver enzymes or bilirubin values. If replicated in phase 3, the lack of a liver signal could allow approval without the monitoring requirements imposed on Veozah. Investors appeared equally enthused, sending AbCellera's stock up 32% to $9.21 in premarket trading Monday from a Friday closing price of $6.93. Next, AbCellera will collect the Week 12 data and talk to its advisors about further development. The results open up “a wide variety of possibilities of how we might take this forward into phase 3 studies to truly maximize the value of the asset and make sure that ABCL635 is able to demonstrate its differentiation potential,” Sarah Noonberg, M.D., Ph.D., AbCellera’s chief medical officer, told investors.

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Aug 10 • 8:24 AM EDT • Health • fiercebiotech.com
Florida Is Betting That NIL Isn't Everything in Recruiting

Rejecting flashy million-dollar bidding wars and luxury penthouses, the Florida Gators are targeting prospects who prioritize professional development and long-term stability over the immediate lure of massive payouts.

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Aug 10 • 7:00 AM EDT • Sports • sports.yahoo.com
RFK Jr. slated to unveil plan targeting loophole that allows chemicals in food supply

The practice known as “generally recognized as safe” allows companies to self-certify the safety of certain food chemicals or substances without strict government oversight.

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Aug 10 • 6:00 AM EDT • Health • washingtonpost.com
Public health alert issued related to potential salmonella contamination recall

The U.S. Department of Agriculture’s Food Safety and Inspection Service (FSIS) has issued a public health alert, specifically targeting meat and poultry products that contain FDA-regulated jalapeños that could be

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Aug 9 • 12:00 PM EDT • Health • wfmj.com
Rouven Kasper details which markets Bayern Munich will be targeting

Bayern continues to look to expand its' profile.

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Aug 9 • 3:00 AM EDT • Sports • sports.yahoo.com
Protect College Sports Act stalls in overnight Senate showdown, vote pushed to September after chaotic evening

The Protect College Sports Act stalled Friday as senators filed amendments targeting conference realignment, women's sports, and NCAA liability.

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Aug 8 • 8:31 AM EDT • Sports • foxnews.com
Hawks' Asa Newell: Targeting larger role

Hawks' Asa Newell: Targeting larger role

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Aug 7 • 11:14 AM EDT • Sports • cbssports.com
Trump tries new tack against birthright citizenship after Supreme Court snub

President Donald Trump signed two executive orders targeting children born to foreign lobbyists and tourists. The orders are certain to face legal challenges.

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Aug 6 • 6:10 PM EDT • Politics • washingtonpost.com
New heart drug targeting inflammation falls short in clinical trial

The ZEUS trial fell short, but Novo Nordisk still has high hopes for HERMES and ARTEMIS.

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Aug 6 • 5:01 PM EDT • Business • cardiovascularbusiness.com
Sanofi suspends chronic lung disease phase 2 study, tied to ‘strategic business reasons’

Sanofi halted a phase 2 trial testing a monoclonal antibody, SAR445399, in non-cystic fibrosis bronchiectasis, Fierce Biotech has learned. The trial, which began only back in April, was a randomized, double-blind, placebo-controlled study to measure the reduction in mucus plug score following treatment with SAR445399 compared with placebo in adults aged 18 to 80 years with NCFB, a chronic lung disease. The trial was officially reported as halted on July 29, the day before Sanofi’s second-quarter earnings call. The decision to pause the trial was made “as part of a company-wide portfolio review for strategic business reasons,” and not due to safety concerns, a Sanofi spokesperson told Fierce. The move to pause the NCFB trial comes during a trying time for Sanofi following a year filled with a series of trial fails. In February, the French pharma ousted CEO Paul Hudson and appointed Merck KGaA leader Belén Garijo, M.D., Ph.D., to steer the ship. Since then, Garijo has been doing a deep dive on correcting the company’s strewn R&D and clinical strategies. On July 24, Sanofi scrapped amlitelimab for atopic dermatitis, despite its lore as being a potential $5 billion blockbuster. During its second-quarter report, the company abandoned two more assets, balinatunfib and itepekimab, following failed trial results in psoriasis and chronic obstructive pulmonary disease, respectively. SAR445399, only first revealed by Sanofi in 2023, is an anti-interleukin-1 receptor 3 monoclonal antibody developed to block the interleukin 1, 33, and 36 cytokine pathways. These pathways can be important in chronic immune-related dermatologic diseases, such as atopic dermatitis and hidradenitis suppurativa, as well as respiratory conditions, such as NCFB. Related Sanofi’s new CEO ‘looking deeply’ at late-stage pipeline as clinical clearout continues NCFB affects roughly half a million people in the U.S., with a global incidence of greater than one million cases. In August 2025, Insmed received FDA approval for Brinsupri, a DPP1 inhibitor targeting neutrophil activation, for treatment of NCFB in adults and kids ages 12 and older. The British biotech Infex Therapeutics showed promising NCFB phase 2a data using their monoclonal antibody, INFEX702, which acts by disabling Pseudomonas aeruginosa, a bacteria known to be a major pathogen of NCFB. Sanofi is currently running a separate phase 2 study testing SAR445399 as a potential treatment for the inflammatory skin condition hidradenitis suppurativa.

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Aug 5 • 2:50 PM EDT • Business • fiercebiotech.com
Here's Why Microsoft Is Encouraging Users to Stay Off Public Wifi Networks

A new hacking campaign is targeting wireless networks at hotels, conference centers, airports, and other hospitality venues in an attempt to steal credentials and compromise devices.

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Aug 5 • 1:30 PM EDT • Technology • lifehacker.com
House Democrats targeting 12 new GOP-held districts, including Lauren Boebert and NRCC Chair Richard Hudson's seats
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Aug 5 • 6:45 AM EDT • Politics • cbsnews.com
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In Texas, a political group bets $6 million on Latino voters coming back to Democrats

Somos PAC is planning an ad campaign targeting three South Texas House districts.

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Aug 3 • 4:11 PM EDT • Politics • baltimoresun.com
Microsoft warns hackers are targeting hotel Wi-Fi networks: What to know, how to protect yourself

Microsoft issued a warning travelers across the world, saying Russian hackers have targeted Wi-Fi networks at hotels, conference centers, and other hospitality venues.

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Aug 3 • 2:06 PM EDT • Technology • abcnews.com
Diamondbacks trade deadline interests

The Diamondbacks are targeting starting pitching depth and a left-handed bat to add to the lineup.

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Aug 3 • 1:37 PM EDT • Sports • arizonasports.com