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Group behind GTA 6 leaks threatens to release alleged full build of game including story mode
Warning reportedly states "Take-Two gets one way out: physical disks and a public apology"
AI Agents Are a Threat to Travel Businesses. Airbnb Could Still Be a Winner.
For the lodging platform’s stock to thrive in the age of bots, it has to turn repeat customers into loyal ones.
Nuclear war, malicious AI pose extinction risk by 2100 among 17 health threats: Lancet
A Lancet commission ranks 17 major threats to health through 2100, with nuclear war and malicious AI carrying real risk of human extinction.
Florida: Shane Beamer's Postgame Comments Should Bother Gators Players
After a demoralizing home loss, the South Carolina Gamecocks’ bold plan to silence The Swamp exposes a lack of grit that threatens to derail Jon Sumrall’s once-promising debut season.
Fire at Nevada, Missouri, tire business threatens nearby building
Firefighters are investigating a fire at David's Tire in Nevada, Missouri, after piles of shredded tires burned, sending thick black smoke into the sky.
Extreme heat threatens maternal health and newborn wellbeing worldwide
Extreme heat has led to a marked increase in the risks faced by pregnant women and their babies, according to a survey of 1,000 healthcare professionals in countries including Brazil, India and Zimbabwe.
US threatens to suspend intel sharing, weapons purchases if Ukraine continues Russia energy strikes, sources say
The Trump administration has warned Ukraine and allies in Europe that the US could suspend intelligence sharing and European purchases of US weapons for Ukraine if Kyiv does not halt its deep strikes on Russian energy facilities, two European officials told CNN.
Politics Unplugged (Full Episode) Oct. 11, 2026
On "Politics Unplugged," political editor Dennis Welch sits down with Republican gubernatorial candidate Andy Biggs for a wide-ranging interview weeks before election day. The conversation is dominated by Governor Katie Hobbs' multi-million-dollar ad campaign accusing Biggs of protecting Warren Jeffs' FLDS cult while he was Arizona Senate President. Biggs forcefully denies the allegations, defending his legislative record and accusing the interviewer of carrying Hobbs' water. He escalates further, claiming Hobbs' rhetoric has led to death threats and that she would be "thrilled" if he were physically harmed. The interview also covers his vote against honoring Capitol Police on January 6th, his call to Rusty Bowers about decertifying the 2020 election, and whether he'd certify results as governor in 2028. Hobbs' office responds with a statement denying the claims. The show closes with a teaser for a Hobbs interview the following week.
Trump could face a new threat in January: A Democratic Senate
Republicans predict that Democrats will not confirm Supreme Court and Cabinet nominees if they retake the Senate in the midterm elections.
America’s elected officials are living in fear
An investigation found that over a two-year period from 2024 to August of this year, thousands of violent threats inundated the lives of elected officials in unprecedented ways.
Thunder’s Quietest Preseason Development Solves Major Offseason Loss
Sharp-shooting guard Jared McCain is emerging as a dynamic perimeter threat, utilizing off-ball versatility and veteran poise to preserve the floor spacing lost during a transformative offseason.
Dual tropical storms hit both US coasts with floods and outages
More than 440,000 homes and businesses from Pennsylvania to Florida are without power and flood threats are rising at both ends of the country as the U.S. deals with a
'GTA 6' Leaker Posts Nude Lucia Video With Threats of Releasing Game Early
Amid threats against Rockstar, Cyberleek is promising GTA 6 fans nude Lucia gameplay in 4k if the leaker's meme coin reaches a market cap milestone
Group threatens to leak ‘full’ GTA 6 build if physical plans aren’t reversed
The ‘Cyberleek’ is threatening its biggest Grand Theft Auto 6 leak yet, if its demands aren’t met…
U.S. Department of Health and Human Services (HHS) Recommends Science-Based Thresholds to Target Dangerous Enhanced Kratom Products
Kratom products credit: CDPH DEA takes action based on updated recommendation from HHS October 11, 2026 - WASHINGTON - On Friday, the U.S. Department of Health and Human Services relesed the following: The U.S. Department of Health and Human Services (HHS) provided a new recommendation to the Drug Enforcement Administration (DEA) that establishes science-based thresholds for 7-hydroxymitragynine (7-OH) and mitragynine pseudoindoxyl (MGPI), potent opioid compounds associated with products marketed as kratom. The Department of Justice today announced that DEA issued new Notices of Intent reflecting HHS’ updated scientific analysis and recommendations, including a new Notice of Intent for 7-OH and MGPI incorporating HHS’ recommended concentration and ratio thresholds. Following a review of available scientific data and comments, HHS Assistant Secretary for Health Admiral Brian Christine, M.D., recommended that DEA use concentration or ratio-based thresholds to determine which products containing 7-OH and MGPI are subject to Schedule I control for purposes of temporary scheduling of these substances under the Controlled Substances Act. The recommendation is designed to target concentrated or chemically altered products while distinguishing them from natural botanical kratom products, which may contain trace amounts of 7-OH and MGPI. “We are drawing a clear line between natural kratom and dangerous, enhanced opioid products,” said HHS Secretary Robert F. Kennedy, Jr. “We listened to the public, followed the science, and developed a clear recommended threshold for temporary scheduling that targets concentrated 7-OH and MGPI without sweeping natural botanical kratom into Schedule I. The Trump Administration will continue taking decisive action against dangerous products that fuel addiction while making sure our policies are grounded in rigorous science.” Under the recommendation, 7-OH and MGPI would be controlled in Schedule I for purposes of temporary scheduling when either substance alone, or their combined amount when both are present: Exceeds 1 milligram per gram in solid powders, encapsulated material, or other solid forms, or exceeds 1 milligram per milliliter in liquid preparations; or When the mass of mitragynine present divided by the mass of 7-OH, or MGPI, or the combined amount of 7-OH and MGPI if both present, is less than 100. The ratio-based approach reflects the alkaloid composition of natural kratom products and provides a way to identify products intentionally enhanced or concentrated with 7-OH or MGPI. Available scientific data indicate that 7-OH occurs naturally in botanical kratom at relatively low or trace levels, while some evidence reviewed by FDA suggests MGPI may also occur at trace levels in some natural or kratom-derived products. FDA's scientific review found that 7-OH is substantially more potent than morphine in preclinical studies, with available data indicating approximately two to nine times greater potency depending on the study. FDA also identified evidence supporting a meaningful risk of opioid-like physical dependence and withdrawal from MGPI. “Our recommendation gives DEA a scientifically supportable framework to distinguish natural botanical kratom from products that have been concentrated or manipulated to deliver dangerous levels of potent opioid compounds,” said Assistant Secretary for Health Admiral Brian Christine, M.D. “This approach allows us to focus on the products that pose the greatest threat to public health.” In July 2025, following an FDA scientific and medical evaluation, HHS recommended that 7-OH above a specified threshold be placed in Schedule I of the Controlled Substances Act. In July 2026, DEA announced its intent to temporarily schedule 7-OH above a specified threshold, and HHS simultaneously sought public comment on the proposed threshold. DEA subsequently temporarily placed MGPI and two synthetic 7-OH derivatives, MGM-15 and MGM-16, in Schedule I. Since then, questions have emerged about how scheduling could affect natural botanical kratom products potentially containing trace amounts of MGPI. The new HHS recommendation responds to those concerns by providing DEA with a more precise threshold based on both the concentration of 7-OH and MGPI and their relationship to mitragynine, the predominant alkaloid in kratom. HHS and FDA will continue working with DEA to protect Americans from dangerous concentrated and synthetic opioid products while ensuring federal policy is grounded in the best available science. Source: HHS
Personal AI agents threaten companies profiting from consumer inertia
Personal AI agents are helping users lower bills and get refunds, exposing companies that rely on customers doing nothing.
Voters are connecting the dots — and it’s bad news for Republicans
Of all the dynamics threatening the GOP this year, the most menacing may be the connection voters are drawing between their economic frustrations and GOP policies.
Video: Living Under Threat of Political Violence
Our reporter Nick Corasaniti interviewed elected officials from across the political spectrum on what it’s like to live and work with threats of political violence.
International Business Machines (IBM) Unveils Real Time App Security Collaboration
International Business Machines (NYSE: IBM) announced a new collaboration with Zscaler and Red Hat to tighten application security for enterprise clients. The joint effort combines IBM and Red Hat software platforms with Zscaler threat intelligence to provide real-time protections at the application layer. The partners plan to coordinate vulnerability discovery, automated policy updates, and validated software remediation workflows for shared customers. This IBM, Zscaler and Red Hat security...
📊 Check out the updated Brasileirão table after Saturday's matches
Matchday 30 of the 2026 Brasileirão kicked off this Saturday (10) with two games.At São Januário, Vasco drew 0–0 with Remo and failed to pull away from the threat of the relegation zone.Later, at...
GTA 6 Leaker Claims to Have Full Build, Threatens to Release It Unless Take-Two Apologizes
The notorious leaker known as Cyberleek is now threatening to release what is claimed to be a playable build of GTA 6 ahead of the game's November 19 launch. According to a post on the leaker's own website, the build supposedly includes the full story mode, playable through to the end credits....
Florida HC Jon Sumrall Admits Gators Have Serious Problem Brewing
After a humiliating blowout at The Swamp, Jon Sumrall faces a crisis as recurring defensive lapses and stagnant quarterback play threaten to derail the Gators' once-promising season.
AI is among 17 potentially ‘catastrophic threats’ that researchers say require targeted action
More than a dozen “interconnected catastrophic threats” pose significant risk to global health and wellbeing through the remainder of the 21st century, researchers say – including the potential for extinction. But targeted action from world leaders can help avoid worst-case scenarios.
Global Experts Identify 17 “Catastrophic” Threats To Human Health This Century – Including 2 With “Extinction Potential”
The commission outlines a 75-year outlook for the threats, taking us the year 2100.
Nuclear war and malicious use of AI threaten end of humanity by 2100, says Lancet assessment
Newly established commission identifies 17 catastrophic threats to human health but says ‘realistic route to act’ on each exists
Satya Nadella: Companies should treat AI models like threats
Microsoft CEO Satya Nadella said companies should assume AI models are compromised and contain them from the start.
GTA 6 leaker CyberLeek is now reportedly threatening to release a full, playable build of the game
GTA 6 leaker CyberLeek has reportedly threatened to release a complete playable build, and wants Take-Two to release the game physically.
GTA 6 Leaker Threatens Rockstar With Doomsday Scenario If Meme Coin Hits $30 Million
Cyberleeks is back and asking for more money
Paraguay will not renounce friendship with Israel despite political costs, VP tells 'Post'
DIPLOMATIC AFFAIRS: In an exclusive interview, Paraguay's vice president pledged to preserve his country's alliance with Israel, and expand cooperation against Iranian threats.
Country music star’s song caught up in college football rivalry: ‘I got death threats’
The singer got a scary response to the hit song.
Ella Langley cancels show due to security threat: ‘Refuse to put anyone in harm’s way’
The singer shared the news just hours before she was slated to take the stage.
Child Psychiatrist: Screen Time Isn't Main Threat to Kids
Columbia's Jonathan Slater urges investment in children's mental health care, not screen limits
Minnesota Vikings Receive Surprising Update for New Orleans Saints Matchup
As Justin Jefferson returns to practice, a fresh hamstring injury to Jordan Addison threatens to derail Minnesota’s stagnant offense ahead of a critical clash with New Orleans.
Prospect funeral home owner accused of stalking, threatening former business partner
PROSPECT, Conn. (WTNH) — The owner of a funeral home in Prospect has been arrested following a state police investigation into his alleged harassment and stalking of a former business partner, acco…
CDFW News | Del Norte County Recreational Razor Clam Fishery Closes Due to Public Health Hazard
California Department of Fish and Wildlife (CDFW) Director Meghan Hertel has closed the recreational razor clam fishery in Del Norte County. This closure comes following a recommendation from state health agencies that determined consumption of razor clams in the area poses a significant threat to human health for domoic acid exposure.
The midterm spending bonanza is threatening democracy like never before.
New on "Stress Test": This cycle's shameless spree is bigger and more brazen than ever. Voters might finally be fed up.
Ruto versus experts: Questions as President mocks science on El Niño threat
Ruto questioned the shifting timelines for the heavy rains associated with the El Niño event.
Editorial: Chicago needs a data center strategy, not another performative stunt
Data centers raise legitimate concerns, but a yearlong moratorium threatens to leave Chicago behind in the AI economy. The city needs smart regulation, not political theater.
AI data centers impact public health. Here’s how to report the story
AI data centers consume vast amounts of power and release emissions. Learn how unpermitted generators and permit loopholes threaten public health.
How these census changes could threaten public health
The Trump administration wants to make three big changes to the U.S. Census, including eliminating questions about race, ethnicity, and sexual orientation and excluding anyone who is not a citizen or “lawful permanent resident."
As World Health Summit opens, IRC warns global health investment in fragile states is declining as disease outbreaks pose growing threat
As the World Health Summit begins, IRC warns that global health cuts are putting lives at risk in the world’s most fragile and conflict-affected states.
Duke's 40-point exhibition victory reveals unexpected new scoring threat
It was a good start, albeit an exhibition for the Blue Devils.
Injury Boost For Newcastle With Will Osula Back In Training
The Denmark international’s return bolsters Matthias Jaissle’s attacking depth, providing a physical, high-intensity threat just as a grueling fixture list across three major competitions looms large.
Ohtani Is One of Dodgers’ Biggest Weaknesses in NLCS
Despite a dominant postseason run, the Los Angeles Dodgers face a looming crisis as Shohei Ohtani’s historic slump threatens to derail their hopes to win another World Series.
Timberwolves' Jonathan Kuminga threatens to slap fan over NSFW nickname
Minnesota Timberwolves Jonathan Kuminga is going viral for the wrong reason. Kuminga threatened a fan for a nickname that he was called.
Flooding threatens supply chains
Flooding across Thailand is disrupting rice logistics and delaying planting for the November harvest, market participants told Platts, Hellenic Shipping News reported. High water levels and strong…
What the law says about armed officers at polling places
What does the law say about armed officials at the polls? That’s one of four questions that a legal scholar answers as Trump administration threats have piled up about voting
Haze not ‘a threat’ to Singapore F1 race, but entertainment could be curbed
Transboundary haze from Indonesian fires has pushed city state’s air quality to unhealthy levels, but track activity will not be affected.
Open science is compatible with research security, says Canada’s chief science advisor
Open science is “not incompatible” with research security and science leaders and policymakers should “demystify” the false dichotomy between the two, according to Mona Nemer, Canada’s chief science advisor. More than a decade ago, EU policymakers were promoting open science, open innovation and open collaboration across the world. It was a political movement that aimed to make scientific research, data, software, publications and methodologies transparent, accessible and reusable for everyone.But that rhetoric has changed over the past few years. After Russia invaded Ukraine in 2022 and Donald Trump came back to power in 2025, international partnerships have become more pragmatic. Countries are trying to implement protectionist policies and governments are increasingly worried about technology espionage. According to Nemer, science can remain open if the sector can come up with improved security protocols that would protect research data from undue manipulation by foreign actors. “If anybody can fiddle with the with the data, then [open science] is actually quite dangerous and quite useless,” she told Science|Business. Universities and research institutions are increasingly vulnerable to attempted espionage and other types of foreign interference. In September, the UK’s domestic counter-intelligence service MI5 issued a security warning against collaborations with the China General Technology Research Institute. And earlier this year, Germany’s Helmholtz Center for Information Security was criticised by federal research minister Dorothee Bär, who told a parliamentary hearing that “existing rules and systems” at the institute “were not suitable” for preventing leaks to China. According to Nemer, universities and research institutions should perhaps follow the example of the private sector, as companies have been able to safeguard their research while still publishing results. “I think that there is a level of research security hygiene that researchers and institutions need to just adopt,” she said. “You don't have to tell Sanofi or IBM how to safeguard their research, which they end up publishing anyway.”While certain areas of research will not be open for collaboration with certain partners, in other areas cooperation is necessary even with researchers based in adversarial countries. “I stress this because politics change,” she said. “Science and politics don't make for good fellows, and whether we like it or not, politics will influence certain things.”Researchers will play an important role in “protecting the integrity of science,” said Nemer. “I think that it's time that there's a commitment to a certain scientific compact, so that citizens don't think that science is actually an open door for espionage and for anti-nationalism.”New partnershipsNemer spoke with Science|Business on the margins of the Hamburg Science Summit on September 17, the day when Canadian Prime Minister Mark Carney called for increased cooperation with the EU, including in science and technology. Canada is looking to strengthen ties with partners in other corners of the world, after the Trump administration threatened to put tariffs on Canadian goods and services and even openly suggested Canada could become the 51st state. In parallel, the US government has indicated it wants to retreat from international science projects, including US collaboration with Europe’s CERN particle accelerator and other big science labs.Related articlesThe stats we need to better understand R&DCanada looks to deepen research and education links with the EUCan researchers trust that AI models won’t leak their ideas?Nemer said the US is still a science “powerhouse,” but Canada and Europe will have to work closely together on global challenges. “It’s important for both [sides], but I think it's also important for the rest of the world, because the cut in funding for development, in health, in regions like Africa and other places, have dramatic effects.” The Trump administration is also planning a review of the Nelson memo, a Biden-era document that mandated that results of federally funded research would be openly available. With that idea being called into question, Nemer said it could be “very disruptive” to scientific collaborations and could jeopardise research on climate change, the Arctic and global health. “When your collaborator suddenly tells you I'm not going to share the data with you as a researcher, if this happens, I think it's very worrisome,” she said. “I'm certainly hoping that a lot of the Canadian institutions, funders, researchers, have started looking at joining forces on databases and using more European research infrastructures,” Nemer added.
Concern after Europeans endorse US science agenda
Germany’s biggest research funder has said it is “concerned” after Berlin, plus several other European countries, endorsed a controversial US-led science policy statement. On October 4, the White House announced that 16 countries, including Germany, the UK, Italy, Greece, Bulgaria, Cyprus, Poland, Japan and South Korea had backed the Kyoto Vision for a Golden Age of Science.The document, agreed on the margins of the annual Science and Technology in Society forum in Kyoto, which gathers science ministers from across the world, appears uncontroversial at first sight. It’s a one-page statement, without any concrete measures, that touches on reducing administrative burden on scientists, experimenting with new funding models and the use of “super intelligence” in science, the Trump administration’s preferred term for artificial intelligence. However, what’s controversial is that much of the language in the Kyoto Vision reflects Science: A New Golden Age, a major policy document released by the White House in July.That document attracted criticism for deriding universities as “legacy institutions” and suggesting money be diverted to new research labs. In a speech in Kyoto on October 4, Michael Kratsios, director of the White House Office for Science and Technology Policy and the report’s author, said that the US was seeking to “diversify the ways that we support research to meet our best scientists where and when they do their best work.” The worry is that the Trump administration may be using genuine dysfunctions in academia as a pretext to defund and disempower universities, which US vice president JD Vance has labelled “the enemy.” Many in Europe also want more experimentation and reform of how science is organised and funded, and agree with criticisms of academia made by Science: A New Golden Age. But some also fear that if the US pushes for reform partially in bad faith, it could politicise and undermine the whole agenda. Washington is currently trying to change federal funding rules so that political appointees can block and cancel scientific grants. It has cut grants mid-project on topics related to diversity and other politically forbidden areas. And last year, it threatened to cut Harvard University’s federal funding unless it admitted a “critical mass” of new faculty and students to create campus “viewpoint diversity.” “Particularly concerned”Because of this wider US political context, the Kyoto Vision’s otherwise innocuous sounding statement that “we encourage experimentation with new institutional models for science that provide varying levels of autonomy, resources and direction” has caused consternation in Europe, particularly from some of Germany’s biggest science organisations. A spokesperson for the German Research Foundation (DFG), the country’s biggest funder, said that it would “closely monitor whether the current US administration uses the Kyoto Vision to restructure research funding to the detriment of research institutions such as universities and their autonomy.” The DFG was “particularly concerned” with the statement’s references to Science: A New Golden Age, they continued. A spokesperson for the German Rectors’ Conference, which represents the country’s universities, said that the reference to “new institutional models” raises “questions on the underlying understanding of academic freedom and autonomy.” Research funding must “guided first and foremost by scientific not political principles,” they went on. Dampen criticismEuropean endorsement of the Kyoto Vision might dampen domestic criticism of the Trump administration’s science policy, some in the US fear, by suggesting international support. “What we saw from Germany, Japan, the UK and other countries, is an impulse that the administration has exploited with our own science reform movement, a belief they can use dialogue to make things better,” said Cole Donovan, director of science policy at the campaigning group Stand Up for Science. “In practice, the administration has done the opposite.” Not a binding statementThere’s been so much concern in Germany that the country’s federal Ministry of Research, Technology and Space put out a statement defending its endorsement of the Kyoto Vision, which it has posted on its website. Related articlesIs metascience being co-opted?European researchers sound the alarm that Trump rule changes will hit cooperationThe US ‘golden age’ science strategy: what Europeans need to know The ministry said that it “should be regarded as a basis for discussion and does not constitute a binding statement.” Backing the statement gives Germany the chance to raise “issues and concerns” with the US during upcoming talks on science and technology scheduled for November. “Although these intentions appear, in principle, to be worthy of support, they will be scrutinised and examined more closely as the process continues,” the statement continues. Super intelligence?A ministry spokesperson confirmed to Science|Business that Germany had broadly endorsed the Kyoto Vision.However, they said Berlin had not agreed to final changes in the statement to refer to AI as super intelligence. In September, facing protests against data centres and polling that suggests US citizens are far more concerned than excited by the technology, Trump issued an executive order that attempts to rebrand AI as super intelligence, following polling on social media.The name change is to “reflect the transformative capabilities of these technologies and the limitless opportunities they create for the American people,” the order says. EU askedThe UK and Italian science ministries did not respond to a request for comment on their endorsement of the Kyoto Vision. Although most EU countries did not endorse the statement, it’s not clear which states the US asked. The White House Office for Science and Technology Policy did not return a request for comment. A European Commission official, speaking under condition of anonymity, said that the US had approached the EU, but too late for the EU to quiz all its member states on whether Brussels should endorse the statement.
Why Sebastian Maniscalco's SiriusXM radio is bad for comedy
SiriusXM replaced its Raw Comedy channel with Sebastian Maniscalco’s Comedy Radio last April. The change threatens a meaningful source of royalties and exposure for midlevel comics.
Trump surprised to hear about tropical storm threatening Gulf Coast
No on I-638: 'Witch hunt' of trans kids is a threat to all girls who play sports
Having grown up in rural Missouri, I’m all too familiar with the way some people exclude, bully and discriminate against people of different backgrounds, re ...
What Bruce Arians Thinks of Buccaneers' 0-4 Start
The Super Bowl-winning coach preaches patience amid a historic slump, but mounting injuries and a daunting October schedule threaten to derail Tampa Bay’s postseason hopes entirely.
What Bruce Arians Thinks of Buccaneers' 0-4 Start
The Super Bowl-winning coach preaches patience amid a historic slump, but mounting injuries and a daunting October schedule threaten to derail Tampa Bay’s postseason hopes entirely.
Dolly Parton's nephew accused of using 'no trespassing' sign, barbed wire to deter process server
Dolly Parton’s estate is alleging that Bryan Seaver, the singer’s nephew and former head of security, is avoiding being served in a lawsuit, which alleges he threatened and extorted her estate.
Duke Disrespected as Undefeated College Football Team; Upset Predicted
Despite a dominant ground game and an unblemished record, the Blue Devils remain overlooked by critics. Now, an impending clash with Georgia Tech threatens their bid for national respect.
Isaac Paredes Proved He's a Threat Behind Yordan Alvarez
The Astros infielder put together a strong 2026 campaign while hitting behind one of baseball's most dangerous bats.
Jimmy Kimmel threatens to call the FCC on Trump for suggesting Iran should bomb California
Jimmy Kimmel threatened to call the FCC on Donald Trump after the president suggested Iran bomb California during a midterm election rally.
Multinationals eye higher risk spending to combat multiple threats
More than two-thirds of multinational companies worldwide expect to increase risk management spending over the next 12 months, yet many doubt their ability to manage increasingly interconnected risks…
Critical funding gap threatens health response in Yemen
The World Health Organization (WHO) warned that significantly more resources are required to scale up its response in Yemen amid escalating conflict and rising needs.
Insurance leaders in Rochester highlight common business coverage gaps
Rochester insurance leaders discuss common business coverage gaps and emerging risks like cyber threats and AI to help companies protect evolving operations.
UM Health-West introduces new security measures
UM Health-West has expanded its safety measures with the help of a new wearable device used to alert the building to security threats. It’s called Canopy Protect, and hospital leaders say they’ve already seen safety improvements since implementing the device about two weeks ago.
IMF chief warns energy shock, public debt and AI boom threaten global growth
Kristalina Georgieva’s warning comes as Brent crude rises above $101 a barrel
Oil prices rise as storms and air strikes threaten supply
Oil prices rose on Wednesday as the market weighed supply constraints from a storm heading for US oil-producing regions and attacks by Yemen's Iran-backed Houthis on Saudi Arabia against increased supplies of Middle East crude.
River Market businesses, residents call for action on homelessness and parking concerns
The city says it recently cleared the largest homeless encampment in Kansas City history, located in the River Market, but some say they're continuing to see threatening behavior.
Kings Coach Christie Believes Sharp Will Become a Fan Favorite
Emanuel Sharp impressed Doug Christie with relentless hustle and grit, signaling a potential breakout as Sacramento’s next shutdown perimeter threat.
CDC: Monitoring Russian plague risk, "prepared" for any threat
The pneumonic plague is the most dangerous version of the plague.
The Jets should change their running back approach
Over the last couple of years, one thing that has frustrated me with the Jets’ approach to offense has been their insistence on using Breece Hall as a do it all back. Hall is a very talented player, but I think it’s clear that he isn’t a complete back. He is an explosive play threat […]
Private owner closes downtown East Lansing parking lot, upsetting businesses
Bob Metzger followed through on threats to close a large portion of a downtown East Lansing parking lot because of a thwarted high-rise development.
Ten Tips to Keep Your Business Cybersafe
Cybersecurity threats can put your business, data and customers at risk. These 10 practical steps can help strengthen your organization’s cyber-readiness.
Politics & Power: From cyberattacks to job losses, what AI means for security & livelihoods worldwide
Nick Allard, dean of the Jacksonville University College of Law, joins News4JAX anchor Bruce Hamilton on this week’s episode of “Politics & Power” to discuss the double-edged sword of AI as both threat and solution and what world leaders must do now.
HOMETOWN HEALTH: Pediatricians warn raw milk can increase risk of life threatening infections
The AAP says the risk is even greater for young children and pregnant women.
Matt LaFleur Puts Packers on Notice After Week 4 Turnovers
Following a sloppy victory over the Tampa Bay Buccaneers, the Green Bay Packers' head coach threatened to bench players who fumble the football.
Austin Simmons Headlines Missouri's Biggest Offensive Threats to Texas A&M
Austin Simmons leads a Missouri offense that has emerged as one of the SEC's biggest early surprises, but Texas A&M will have to account for three other playmakers as well.
Why India is getting serious about ending the Ukraine war
US tariff threats and drone strikes on an Indian-owned factory are pushing Delhi to shift from passive advocacy to active peacemaking.
Angels To Face Decision On Ill-Fitting First Baseman
Nolan Schanuel’s elite contact skills contrast sharply with a glaring lack of power, forcing the Halos to weigh his high-floor production against more traditional middle-of-the-order threats.
Offensive Line Looks Offensive: Spartans Rank Last in Sacks Allowed
From personnel shifts to coaching failures, a crumbling front wall has left the Spartans reeling as record-breaking sack numbers threaten to derail the Pat Fitzgerald era.
Comcast Business 2026 Cybersecurity Threat Report: 79.3 Billion Events Show AI Pressurizing the Threat Landscape
Comcast Business has released its 2026 Cybersecurity Threat Report, an analysis of 79.3 billion cybersecurity events detected across its cybersecurity custom...
Cybersecurity portal to fight bad guys open for business: NMFTA
The NMFTA has launched its threat portal, where targets of successful and unsuccessful cyberattacks can share their stories.
Sexual misconduct allegations threaten to topple veteran LA Democrat
LA Democrat Jimmy Gomez is facing a strong socialist challenger.
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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