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Results for " alli " 3,674 found 🔀 AI-powered Shuffle

Fast food, fries and science: Inside U-M's lab studying cravings

The experiment starts before anyone takes a bite. There's no drive-thru. No cashier calling the next order. No glowing sign announcing the restaurant is open.

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Jun 30 • 9:00 AM EDT • Science • news.umich.edu
Michigan Senate candidate Dr. Abdul El-Sayed responds to criticism calling his campaign ‘divisive’
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Jun 30 • 7:52 AM EDT • Politics • cnn.com
Why can’t college sports be fixed? Look at Michigan’s response to Dusty May leaving

Michigan’s president calling for reform without sacrificing “competitive advantage” is why college sports aren’t getting fixed.

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Jun 30 • 6:05 AM EDT • Sports • nytimes.com
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'Staying away from the middle will be hardest': Sachin Tendulkar's emotional message to Ben Stokes after retirement

Sachin Tendulkar led heartfelt tributes to Ben Stokes following his retirement from international cricket. Tendulkar lauded Stokes' fearless approach, match-winning ability, and inspirational leadership, calling him one of England's finest all-rounders and captains. Stokes, who bowed out after a Test series loss, expressed contentment with his decision, citing years of physical and mental demands as the primary reason for stepping away.

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Jun 30 • 3:38 AM EDT • Sports • sports.yahoo.com
England maternity commissioner role would be ‘fundamentally dangerous’, says campaigner

Founder of Maternity Safety Alliance says recommendation in Amos report will not solve wider cultural problems

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Jun 30 • 3:34 AM EDT • Health • theguardian.com
Community Rallies for West Hartford Resident, Business Owner Taken Into ICE Custody

Seyo Cecunjanin, who has lived in West Hartford since 1997 and is the owner of Portobello Restaurant on Park Road in West Hartford and The Laundry Room on the Ave on Farmington Avenue, also in West Hartford, was taken into custody in the parking lot of the Dunkin Donuts at 56 Park Road, just east of his restaurant, on Saturday, June 20.

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Jun 29 • 8:58 PM EDT • Business • ctnewsjunkie.com
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‘Grateful and humbled’

MARSHALL — Two individuals who played important roles in building the Marshall baseball program into one of the state’s best were honored Sunday evening with induction into the Marshall Baseball Hall of Fame. Steve Fleck and Blaine Schnaible became the 20th and 21st members of this select group during a pre-game ceremony prior to the […]

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Jun 29 • 8:00 PM EDT • Sports • marshallindependent.com
Xtalks Launches Life Sciences United (XLSU), a New Global Alliance for Nonprofit Life Science Organizations

Xtalks is pleased to announce the launch of Xtalks Life Sciences United (XLSU), a global alliance and collaborative network designed to bring together nonprofit organizations across the life sciences.

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Jun 29 • 5:03 PM EDT • Science • finance.yahoo.com
[8-K] ALLIANCE ENTERTAINMENT HOLDING CORP Reports Material Event

Alliance Entertainment Holding Corporation reports that majority stockholders delivered a written consent on June 24, 2026 approving a major charter change.

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Jun 29 • 4:46 PM EDT • Entertainment • stocktitan.net
West Hartford business owner detained by ICE, elected officials call for his release

A West Hartford business owner was taken into ICE custody last weekend outside a Dunkin’ location on Park Road, sparking a response from elected officials who are calling for his release.

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Jun 29 • 3:58 PM EDT • Business • wfsb.com
Lizzo slams 'Khia Asylum' meme for 'flopping' pop stars: 'Weapon that targets only women'

Lizzo slammed the 'Khia Asylum' meme often use for 'flopping' pop stars: 'A tool to bully artists,' she said, calling the title itself 'backhanded' for mocking a 'pillar in the Black community.'

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Jun 29 • 11:04 AM EDT • Entertainment • ew.com
The Anti-Data-Center Movement Is Reshaping Michigan Politics

Climate activist Will Lawrence cofounded the Sunrise Movement. Now, he has shifted his focus in his attempt to compete for a swing-district seat by calling for a data center moratorium.

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Jun 29 • 6:30 AM EDT • Politics • wired.com
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Apple accuses India of 'copy-pasting' rivals' claims in antitrust investigation

Apple has accused Indian antitrust investigators of "copy-pasting" its rivals' claims and failing to properly conduct its own investigation in concluding the U.S. tech giant breached competition laws, ​calling for the findings to be quashed, regulatory papers reviewed by Reuters showed.

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Jun 29 • 5:59 AM EDT • Business • reuters.com
iPhone 18e Won't Get ProMotion Display, Says Leaker

Apple's upcoming iPhone 18e will have the same display refresh rate as the existing iPhone 17e, according to a prominent Chinese leaker. Discussing Apple's product plans for 2027 in a Weibo post, Digital Chat Station claimed that the next generation of Apple's low-cost iPhone will feature the same 60Hz low-temperature polycrystalline silicon (LTPS) TFT panel as the current model.

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Jun 29 • 5:54 AM EDT • Technology • macrumors.com
Caldwell University Professors Join Nationwide "Phage Hunters" Science Alliance

Caldwell, NJ – Three professors of Caldwell University’s Department of Natural Sciences, Dr. Maria Agapito, Dr. Darryl Aucoin, and Dr. Hector Loyola Irizarry, attended the Howard Hughes Medical Institute (HHMI) […]

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Jun 28 • 11:01 PM EDT • Science • caldwell.edu
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Zohran Mamdani says he and allies he endorsed carry a ‘national message’

Mayor says progressive peers who swept primaries speak to Americans ‘coast to coast’ as moderates have reservations

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Jun 28 • 2:24 PM EDT • Politics • theguardian.com
On anniversary of disastrous debate, Biden rallies Democrats at a casino

President Joe Biden spent the second anniversary of his disastrous debate performance at a Maryland casino, giving the keynote speech at an annual fundraiser for Maryland Democrats.

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Jun 28 • 9:24 AM EDT • Politics • washingtonpost.com
Progressives look to Colorado as next test of a rising movement

Melat Kiros, a 29-year-old democratic socialist and lawyer, is challenging 15-term Rep. Diana DeGette for a solidly blue seat in Denver, where she and her allies hope voters are ready for change.

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Jun 28 • 6:30 AM EDT • Politics • cnn.com
Bullseye! Enormous 'bow and arrow' galaxy is unlike anything radio astronomers have ever seen — Space photo of the week

Astronomers and citizen scientists have discovered RAD-BAARG, a radio galaxy with a striking bow-and-arrow shape, offering a rare direct view of a galaxy falling into the environment of a galaxy cluster.

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Jun 28 • 6:00 AM EDT • Science • livescience.com
Airlines Are Installing New Luxury Seats, but No One Is Allowed to Sit in Them

Lie-flat seats in private pods face long waits for safety certifications, delaying debuts for carriers’ high-end offerings.

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Jun 28 • 5:30 AM EDT • Business • wsj.com
Juventus hold exploratory talks for Soule’s return

Matias Soulé is among the candidates to leave Roma in the coming days and be sacrificed on the altar of capital gains. The Argentine winger isn’t pushing to leave; on the contrary, he’s stalling....

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Jun 28 • 3:20 AM EDT • Sports • sports.yahoo.com
Two years after their last debate, Biden jabs at Trump: ‘What a loser’

As he rallied Maryland Democrats at a state party fundraiser Saturday night, former President Joe Biden decried the actions of the man who succeeded him in the White House, painting him as vain and corrupt.

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Jun 28 • 1:05 AM EDT • Politics • cnn.com
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Florence community rallies for local business owner diagnosed with brain tumor, here’s how you can help

The Florence community held a fundraising event for a local business owner who was diagnosed with a brain tumor for the second time.

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Jun 27 • 11:42 PM EDT • Business • wlbt.com
Report: Astros to Call Up RP Miguel Ullola

The Houston Astros are calling up pitching prospect Miguel Ullola, according to a report from Chandler Rome of The Athletic. Ullola, 24, is ranked as the Astros #11 prospect per MLB.com. Ullola was converted to a reliever this season in an effort to help him with his command issues and be someone the team could […]

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Jun 27 • 7:33 PM EDT • Sports • sports.yahoo.com
Game 84: Rockies at Twins

First Pitch: 6:10 pm CDTTV: Twins.TVRadio: TIBN / WCCO 830 / The Wolf 102.9 FM / Audacy One night after what many are already calling the dumbest game of all time, Target Field is playing host to the Battle of the Mikes. Mike check, one-two, one-two. Heh. Hilarious. For the Twins, it’s Mike Paredes, who has […]

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Jun 27 • 6:00 PM EDT • Sports • sports.yahoo.com
Carlisle Cathedral, University of Cumbria secure grant to explore science and faith connections in local farming landscapes - Lutheran Alliance for Faith, Science and Technology

Carlisle Cathedral and the University of Cumbria won a £9,850 grant to explore how science and faith connect in Cumbria's farming landscapes.

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Jun 27 • 3:19 PM EDT • Science • luthscitech.org
Scientists in Synagogues grant program to name finalists in July - Lutheran Alliance for Faith, Science and Technology

Sinai and Synapses has launched a $5,000 Scientists in Synagogues grant program promoting Judaism and science. Finalists will be named in July.

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Jun 27 • 2:59 PM EDT • Science • luthscitech.org
Brad Paisley: Data center project near Nashville Zoo is 'a monstrosity'

14-time Country Music Award winner Brad Paisley is calling on Nashville to prevent the construction of a data center near the city's zoo.

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Jun 27 • 2:39 PM EDT • Business • businessinsider.com
Los Alamos Faith and Science Forum launches 2026 Summer Series - Lutheran Alliance for Faith, Science and Technology

The Los Alamos Faith and Science Forum's 2026 summer season is on, offering weekly presentations on humanity’s most enduring scientific and spiritual questions.

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Jun 27 • 2:23 PM EDT • Science • luthscitech.org
The sky is not falling. Americans are getting healthier.

Despite declining obesity and heart disease rates, increasing cancer survival rates, and a record high life expectancy, politicians from both parties are pushing costly and ineffective policies to …

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Jun 27 • 2:00 PM EDT • Politics • thehill.com
Central NY farm in business for more than 80 years faces costly rebuild after fire

Community members and farmers have rallied to help the farm cleanup and rebuild after a fire destroyed its greenhouses.

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Jun 27 • 9:00 AM EDT • Business • syracuse.com
Colorado Politics Calendar June 29-July 5

CoPo’s weekly political calendar will help you find political and public-policy events throughout Colorado. It includes candidate and issue campaign events, public policy meetings, court hearings, state and local party conventions, assemblies, debates, rallies, parades, speaking engagements, traveling dignitary appearances, water meetings, book signings, county commission hearings, city council meetings and more. As a subscriber, […]

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Jun 27 • 7:09 AM EDT • Politics • coloradopolitics.com
In Trump’s America, two very different views of Christianity in politics emerge

Adherence to organized religion is falling in the United States, but defenders of the religious right are ascendant in positions of power in the Trump administration.

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Jun 27 • 6:30 AM EDT • Politics • cnn.com
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Why the CEO of AllianceBernstein says you should worry about an AI bubble

"Is it likely we have a meaningful correction? I think it is," AllianceBernstein's CEO told Business Insider in an interview.

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Jun 27 • 5:10 AM EDT • Business • businessinsider.com
Nigel Farage’s anti-WHO campaign moves to US with allies added to board

Relocation of Action on World Health raises questions over why Reform UK leader is involved in a US pressure group

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Jun 27 • 5:00 AM EDT • Health • theguardian.com
Nigel Farage’s anti-WHO campaign moves to US with allies added to board

Relocation of Action on World Health raises questions over why Reform UK leader is involved in a US pressure group

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Jun 27 • 5:00 AM EDT • Politics • theguardian.com
Rockies' Jake McCarthy: Tallies sixth homer

Rockies' Jake McCarthy: Tallies sixth homer

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Jun 27 • 2:39 AM EDT • Sports • cbssports.com
Peters, Bergman lead Michigan delegation in calling on Small Business Administration to approve disaster declaration

WASHINGTON, DC — U.S. Senator Gary Peters (D-MI), Ranking Member of the Homeland Security and Governmental Affairs Committee, led members of the Michigan Congressional Delegation in urging the Small Business Administration (SBA) to support Michigan Governor Gretchen Whitmer’s request for an administrative disaster declaration following the severe thunderstorms, tornadoes, high winds, large hail and torrential […]

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Jun 26 • 8:00 PM EDT • Business • thealpenanews.com
Politics Unusual: Co-chairs of NYC-DSA, Rep. Malliotakis

In this episode of Politics Unusual, FOX 5 NY's political reporter Morgan McKay sits down with the co-chairs of New York City's Democratic Socialists of America to discuss their success on primary night. Also, a conversation with Rep. Nicole Malliotakis about the rise of democratic socialism and the direction the Democratic Party could take in the coming years.

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Jun 26 • 6:28 PM EDT • Politics • fox5ny.com
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Are You Falling Into These 5 AI Traps? Here's How Smart Leaders Avoid Them.

Artificial intelligence is making founders fall into the same leadership traps. Here's how to make sure you avoid them.

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Jun 26 • 4:00 PM EDT • Business • entrepreneur.com
MSU Vet Tech program awarded $150k NIFA-USDA grant

Morehead State University's nationally ranked veterinary technology program was recently awarded significant financial support to help it maintain its place as the #1 program of its kind in Kentucky. The National Institute of Food and Agriculture (NIFA), part of the United States Department of Agriculture (USDA), awarded MSU's vet tech program a $150,000 NIFA-USDA grant for equipment to support small and large veterinary technology education and workforce competency at MSU. Learn more about veterinary technology programs at MSU by emailing Staton at a.staton@moreheadstate.edu or calling 606-783-2328. Find out more about MSU's veterinary technology program by calling 606-783-2662.

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Jun 26 • 1:39 PM EDT • Science • moreheadstate.edu
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Tanzania Bans Political Rallies, Bracing for Gen-Z Protests

Tanzania’s authorities banned political rallies and placed the country on high alert for youth-led protests against increased authoritarianism.

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Jun 26 • 9:33 AM EDT • Politics • bloomberg.com
Newsom urges a national 'billionaires' tax' while fighting one in California

California Gov. Gavin Newsom is calling for a national “billionaires' tax” and suggests the U.S. government should own a stake in AI companies.

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Jun 26 • 9:01 AM EDT • Politics • ksat.com
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‘The Hot Zone’ led me to work with Ebola patients. Now I have mixed feelings about the book

“The reality of Ebola is simultaneously less sensational and far more challenging than most people imagine,” writes Krutika Kuppalli.

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Jun 26 • 4:30 AM EDT • Health • statnews.com
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What we learned as Bryce Harper caps Phillies' shocking comeback trilogy

The Phillies erased another five-run deficit, rallied late again and reached the season’s halfway point with another reminder of how much has changed.

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Jun 25 • 9:50 PM EDT • Sports • nbcsportsphiladelphia.com
It's Xbox's turn (again), as console prices keep going up

Microsoft announced a price hike for the Xbox Series consoles today, the third in little over a year. Effective August 1, the Xbox Series S, which launched in 2020 for $300, will cost $500 in the U.S. The Xbox Series X, which launched in 2020 at $500, will go for $800. This follows a round of PlayStation 5 price increases from Sony this spring, and a slow-motion increase for Nintendo’s Switch 2, which will kick in in the U.S. in September. (Mind you, there were also eight video game industry price hikes in six months of 2025). The chart up top shows the sudden ascent of console prices over the past year, a sudden surge in an already unusual hardware generation. Prices had been flat for years, now “up” is the new “flat.” Game console prices used to go down across the length of a console generation, but not this time around. Microsoft’s explanation for the new price hike today: We hoped another price increase would not be necessary, and we have spent the last several months working with suppliers on options. Unfortunately, console storage and memory prices have increased by more than 2.5x and we expect another doubling by the fall of 2027. The entire consumer electronics industry is struggling with the current components crisis, but the effects are particularly hard on consoles. Unlike phones, computers, speakers, and other consumer devices, consoles are typically not sold at a profit, but instead for less than they cost to make. This is an issue well beyond game consoles. Apple announced price hikes on its computers and tablets today as well. Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Item 2: Brutal Bungie cuts Bungie laid off “most” of its Destiny development team and some developers who worked on Marathon, the newest game from the struggling Sony-owned studio. A WARN notice issued by Sony to Washington State, where Bungie is based, tallied cuts impacting 292 workers, effective next month. That’s strictly for Bungie/Sony jobs in Washington and wouldn’t account for any elsewhere. The video I clipped below shows the redacted list of Bungie cuts filed to Washington State officials. As you’ll see, I had to scroll for a while… In a note emailed to PlayStation workers and published online, PlayStation game studios chief Hermen Hulst offered the following explanation for these latest cuts at Bungie: This is painful news, especially for talented colleagues whose roles have been eliminated. This decision was made only after extensive discussion and careful consideration, and I want to provide some context on how we arrived here. Over the past several months, together with Bungie leadership, we reviewed the studio’s long-term direction, development priorities, resource needs, and role within our broader portfolio strategy. We explored multiple alternatives before concluding that a reduction was necessary to align the studio’s resources with its current priorities and long-term goals. In 2022, Sony bought Bungie for $3.7 billion. The studio’s marquee game, the multiplayer live service shooter Destiny 2 was losing popularity at the time. Its next game Marathon, released earlier this year, has been well-reviewed but had a slow start. Bungie is renowned for making great shooter games, and Destiny fans have mourned the wind-down of Destiny 2. They’ve also expressed bewilderment over reports that Destiny 3 is not, per Bloomberg, immediately in the cards.

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Jun 25 • 8:21 PM EDT • Technology • gamefile.news
Lionel Richie postpones concerts after falling ill during tour opener

Lionel Richie is pausing his return to the stage after abruptly falling ill during the opening of his new tour.

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Jun 25 • 7:37 PM EDT • Entertainment • centraloregondaily.com
Making Our Own Luck

We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.

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Jun 25 • 4:48 PM EDT • Science • goodscience.substack.com
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Trump’s politics of emergencies leaves GOP allies scrambling again

In upending plans to sign a bipartisan housing bill, the president illustrated one of his favored tactics: declaring a policy preference to be an emergency.

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Jun 25 • 1:43 PM EDT • Politics • washingtonpost.com
Poppi founder speaks about building a billion-dollar soda business

Allison Ellsworth, the founder of the viral soda brand Poppi, sits down with NBC News' Savannah Sellers to discuss how she turned a personal health issue into a billion-dollar cultural phenomenon.

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Jun 25 • 11:26 AM EDT • Business • nbcnews.com
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Supporters of KY’s Lee Specialty Clinic supporters want politics put aside to avert cuts

Over 100 people rallied in support of Lee Specialty Clinic in Frankfort Wednesday afternoon and testified on the importance of its services.

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Jun 25 • 6:58 AM EDT • Politics • kentucky.com
Ted Cruz’s not-so-secret White House dreams have gotten JD Vance’s attention and annoyed Trump allies

An ice cream social at a supporter’s house. A meet-and-greet with veterans. A roundtable with sheriffs. An evening rally at a sweltering barbecue joint and a winding photo line afterward.

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Jun 25 • 5:00 AM EDT • Politics • cnn.com
Rubio reassures Gulf allies as US-Iran talks advance

Tehran has already portrayed the deal as a victory

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Jun 25 • 2:32 AM EDT • Politics • euractiv.com
Alliance Orthopedics high school sports polls June update. Who are the winners?

That's a wrap on the spring season for Shore Conference high school sports. Let's go over the list of winners of polls sponsored by Alliance Orthopedics

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Jun 25 • 12:44 AM EDT • Sports • sports.yahoo.com
How architecture influences political activity

A new study in Ghana shows residents in semi-communal housing are more likely to vote, attend rallies, and take part in political campaigns, compared to people in more private forms of housing.

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Jun 25 • 12:00 AM EDT • Politics • news.mit.edu
NATO’s Leader Makes His Case to Trump for Preserving the Alliance

Using charts, Secretary General Mark Rutte appeared to defuse the president’s anger by showing that European countries were “equalizing” defense spending with the U.S.

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Jun 24 • 8:26 PM EDT • Politics • nytimes.com
South Korea juggles digital sovereignty and alliance politics

South Korea’s closest allies are increasingly challenging its control over digital platforms, data and technological infrastructure.

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Jun 24 • 8:00 PM EDT • Politics • eastasiaforum.org
My Music Row Story: Big Machine Records/Nashville Harbor Records & Entertainment’s Allison Jones

With over 35 years of experience in the music industry, Allison Jones serves as EVP of A&R at [...]

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Jun 24 • 4:36 PM EDT • Entertainment • musicrow.com
Rubio: US ‘completely aligned’ with Gulf allies on Iran
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Jun 24 • 3:59 PM EDT • Politics • aljazeera.com
Gas prices, health, quality of life drive push for more Coloradans to trade four wheels for two, even if safety is a worry

Bike to Work Day brings out the cyclists in Denver, but many already pedal to their jobs and back.

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Jun 24 • 2:25 PM EDT • Health • cpr.org
Online violence against women in politics: what shapes political party responses to technology-facilitated gender-based violence?

Political parties have a primary role to play in tackling online violence against women and gender diverse politicians. While the prevalence and impact of TFGBV, such as coordinated disinformation campaigns, deepfake image-based sexual abuse or trolling are well documented, many parties are still building their knowledge on how to respond effectively and have not put in place internal practices and policies that respond to the rapidly evolving, poorly regulated digital ecosystem. About the ReportIn order to promote and protect fair and democratic participation in politics, this ALIGN Report explores what political parties are doing in response to TFGBV and what factors shape their action. The findings, based on existing literature and interviews with gender and politics professionals, indicate there are three sets of factors which donors, civil society and practitioners should consider when designing action to support political parties to respond to TFGBV internally. These are: (1) gender norms; (2) socio-political environment; and (3) internal party factors.Key messagesUnequal gender norms are ubiquitous across politics, shaping expectations of leaders to be strong and assertive, and practices of political parties to uphold masculinist values and sustain cultures of silence. These often lead to weak response to TFGBV against women politicians.The socio-political context can incentivise or disincentivise action, depending on the salience of gender issues, which are increasingly weaponised. Electoral competitiveness, domestic laws (i.e. quota requirements), and even the political system or global normative frameworks influence political will to act.Internal party factors that shape responses will vary across countries and contexts, but include: structures to enforce codes of conduct, policies and reporting mechanisms on (TF)GBV, political ideology, extent of centralisation of leadership, and crucially the meaningful participation of women in decision-making positions, not least through internal women’s wings.Party responses can be seen as a spectrum, with actions falling between active discouragement to address TFGBV to commitment to transform unequal norms and practices within the party.About the ToolkitTogether with the report, this ALIGN toolkit offers gender professionals and others working on democratic strengthening a set of guiding questions and reflection prompts to identify which responses could be most effective and suitable in different contexts. These actions can complement other solutions to TFGBV, such as regulations promoting safety by design. The assessment spans a broad range of factors including: (1) different manifestations of gender norms, (2) the socio-political environment and (3) internal party structures.Key messagesPolitical parties are duty-bound to take action internally to respond to the significant threats posed to women members and candidates, including from their own party colleagues, affiliates and political peers.Existing party approaches to TFGBV can be assessed along a spectrum which ranges from active discouragement and passive acceptance to minimal response and transformative change.To generate effective and context-appropriate solutions to TFGBV, it is important to consider how gender norms shape leadership expectations and internal party practices, while also analysing the impact of the socio-political environment. While actions to support women to stay safe online are very common, codes of conduct and measures to strengthen women’s voice and power in the parties are proposed as most transformative solutions.

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Jun 24 • 2:08 PM EDT • Politics • odi.org
Oprah reveals Whitney Houston moment she begged audience not to share

Oprah Winfrey has revealed she "begged" audience members not to release photos of Whitney Houston falling off the stage at her show in 2009.

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Jun 24 • 11:04 AM EDT • Entertainment • centraloregondaily.com
Mamdani slate sweeps Democratic primaries in New York, ousts 2 incumbents from Congress

Top allies of New York Mayor Zohran Mamdani have defeated establishment-backed Democrats in New York's congressional primary elections.

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Jun 23 • 11:50 PM EDT • Politics • pbs.org
Maryland Primary Politics

After months of campaign rallies, ads, mailers, endorsements, debates, and yes, some political mudslinging; maryland voters are getting the final say on this primary Tuesday. Polls will be closing soon and we could be just hours away from getting a clear picture of who won, lost, and what it all means for the future of […]

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Jun 23 • 6:46 PM EDT • Politics • whur.com
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Trump touts falling oil prices, economy at Pennsylvania rally

The president spoke at a Mack Trucks factory in Macungie on Tuesday

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Jun 23 • 5:18 PM EDT • Politics • spectrumlocalnews.com
Trump touts falling oil prices, economy at Pennsylvania rally

The president spoke at a Mack Trucks factory in Macungie on Tuesday

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Jun 23 • 5:18 PM EDT • Politics • spectrumlocalnews.com
Trump touts falling oil prices, economy at Pennsylvania rally

The president spoke at a Mack Trucks factory in Macungie on Tuesday

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Jun 23 • 5:18 PM EDT • Politics • spectrumlocalnews.com
Netflix’s New #1 Show Is a Crime Thriller Everyone Can Finally Agree on

A new Netflix thriller has taken over the number 1 spot, knocking a usual chart-topper down the rankings. Viewers are calling it binge-worthy, twist-filled, and impossible to pause once you start. Find out more here.

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Jun 23 • 11:49 AM EDT • Entertainment • purewow.com
Watch the first-ever video of a newfound spider’s spring-loaded death trap

Scientists discovered that the Australian “ballista spider” uses a silk cone trap to catapult prey into its web, a feat of spider engineering never before observed.

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Jun 23 • 9:50 AM EDT • Science • cnn.com
Rockies rally for 3-2 win over Red Sox

Jake McCarthy hit a three-run triple down the left-field line in the ninth inning and the Colorado Rockies rallied to beat the Boston Red Sox 3-2.

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Jun 23 • 6:27 AM EDT • Sports • spectrumlocalnews.com
AI could breach government and business defenses in months, US and its intelligence partners warn

AI models capable of launching major cyberattacks that could overwhelm the defenses of governments and businesses are months – not years – away, an international alliance of intelligence agencies warned in a joint statement.

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Jun 23 • 2:21 AM EDT • Business • cnn.com
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Ranking SEC recruiting classes via average commit distance

The 2027 recruiting cycle is moving at warp speed this summer. Prospects are making their college decisions in droves amidst official visit season. Dominoes are falling and classes are being built. Looking at the SEC, many programs are in states that are littered with blue-chip talent. You’ll often see the top schools go nationwide in […]

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Jun 22 • 9:50 PM EDT • Sports • sports.yahoo.com
Listening for quantum oscillations in the Kondo insulator YbB12

Magnetic quantum oscillations have been unexpectedly observed in insulators, where freely moving charge carriers are not expected to exist. A joint study by researchers from Tokyo University of Science, The University of Tokyo, and Kobe University investigated this puzzling behavior in the Kondo insulator YbB12 using ultrasound. While no oscillations were detected in the insulating state, clear signals emerged after the material became metallic, offering new insight into unusual quantum behavior in next-generation materials.

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Jun 22 • 8:00 PM EDT • Science • eurekalert.org
Move over, Paul Dano: Quentin Tarantino will star in new film

Quentin Tarantino continues delaying his plan to retire from directing, opting instead to step in front of the camera for 'Tangled Up in Blue.' He will star alongside Kylie Minogue, Allison Williams, Jason Isaacs, Sofia Boutella, and Wu-Tang Clan rapper RZA.

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Jun 22 • 7:35 PM EDT • Entertainment • ew.com
Sacramento business groups form coalition to fight for reforms at City Hall

The alliance plans to lobby for fiscal reforms, speedier approvals for major projects and to set public safety as the city’s top priority.

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Jun 22 • 6:16 PM EDT • Business • sacbee.com
Romania’s Political Turmoil Deepens After PM Hopeful Loses Vote

Romania’s prime minister nominee failed to win parliamentary approval for his proposed cabinet, prolonging a political deadlock that risks stalling key reforms for crucial European Union recovery funding.

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Jun 22 • 4:31 PM EDT • Politics • bloomberg.com
Dodgers Promote 21-Year-Old Pitching Prospect to Double-A

The Los Angeles Dodgers are calling No. 8 prospect Christian Zazueta up to Double-A, per ESPN’s Kiley McDaniel. Zazueta is just 21 years old, and has shot up the Dodgers’ system since his arrival ahead of the 2024 season. The…

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Jun 22 • 2:08 PM EDT • Sports • sports.yahoo.com
Judge says Trump DOJ subpoenas of Tim Walz and other Democrats are unconstitutional

A federal judge on Monday blocked the Justice Department from forcing Minnesota Gov. Tim Walz and other officials to turn over records in its probe of Democratic resistance to the Trump administration’s immigration crackdown, calling the move retaliatory.

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Jun 22 • 1:38 PM EDT • Politics • cnn.com
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Federal judge halts Trump administration effort to subpoena Walz in immigration enforcement probe

A federal judge has blocked an attempt by the Trump administration to subpoena Minnesota Gov. Tim Walz and other state officials, calling it an effort to “harass and retaliate against them.”

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Jun 22 • 1:26 PM EDT • Politics • pbs.org
New-to-science spider builds trap that flings ants into the air

A spider living in the rainforests of Queensland, Australia, builds a snare trap reminiscent of a Roman-era ballista weapon that it uses to catapult green tree ants into a web 30 centimetres above

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Jun 22 • 11:00 AM EDT • Science • newscientist.com
Savannah Guthrie praises husband Mike Feldman in rare Father's Day post

"Today" show host Savannah Guthrie shone the Father's Day love light on her husband Mike Feldman, calling her supportive spouse of 12 years the family's "hero."

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Jun 22 • 9:51 AM EDT • Entertainment • centraloregondaily.com
SoHo Business Alliance sues Tampa over public records

The South Howard Business Alliance is suing the City of Tampa for failing to provide records requested under Florida's Public Records Law.

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Jun 22 • 9:48 AM EDT • Business • wmnf.org
Earth’s mantle may be hiding an ocean’s worth of water 410 miles down - Futura-Sciences

An estimated 4.4 billion years ago, a series of planetary collisions delivered the vast majority of Earth’s water budget to a world whose surface was still a bubbling, glowing ocean of molten rock. As this global magma ocean slowly cooled and crystallized over millions of years into the planet’s first...

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Jun 22 • 9:00 AM EDT • Science • futura-sciences.com
Halo: Campaign Evolved Main Menu Video Sparks Fan Debate Over Ring Detail

Over the weekend, Halo Studios released a 6-hour video of the Halo: Campaign Evolved main menu, which, as you’d expect, contains the iconic Halo music from the original game. But what you might not have expected is the debate the remake’s new Halo ring has sparked, and some fans calling it too detailed.

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Jun 22 • 8:48 AM EDT • Technology • ign.com
In Washington and Around the World, Alliances Are Rapidly Fraying | WSJ Politics Newsletter for June 22

Plus, more pool problems for Trump, and Jay Clayton remains in limbo over the post of director of national intelligence

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Jun 22 • 7:01 AM EDT • Politics • wsj.com
From Big Tex to Prague Castle, a Dallas business executive's first year as ambassador

With the Czech national team calling North Texas home during the World Cup, Nicholas Merrick is working to strengthen a relationship generations in the making.

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Jun 22 • 7:00 AM EDT • Business • yahoo.com
Scotland can 'go far' in World Cup

The Scots sit on one win and one defeat so far and face Brazil on Wednesday (23: BST). "If we just get that 10% more out of the group and that's all it is for me, I think we can go deep in this tournament," former Hearts, Motherwell and Rangers midfielder Halliday told the BBC's Scottish Football Podcast.

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Jun 22 • 5:32 AM EDT • Sports • sports.yahoo.com
Bob on Business: Rosedale retail? Texas Wesleyan names real estate firm to market spaces

Also, private equity gets wasted; acquisitions; Texas twister real estate deals; real estate group uses the force; and deals in Alliance.

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Jun 21 • 5:36 PM EDT • Business • fortworthreport.org
UK Parliament to debate whether to open inquiry into Israel lobby's 'influence' over UK politics

UK parliament is set to debate a petition calling for an inquiry into alleged Israeli influence in British politics after it passed the 100,000-signature threshold.

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Jun 21 • 5:17 PM EDT • Politics • jpost.com
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'Our hero': Savannah Guthrie celebrates husband in Father's Day post

"Today" show host Savannah Guthrie shone the Father's Day love light on her husband Mike Feldman, calling her supportive spouse of 12 years the family's "hero."

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Jun 21 • 3:55 PM EDT • Entertainment • centraloregondaily.com
Trump's Iran gamble divides GOP hawks and 'America First' conservatives over what victory looks like

Trump's Iran memorandum of understanding divides GOP as hawks like Cassidy and Cruz clash with allies over whether the deal surrenders leverage.

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Jun 21 • 11:39 AM EDT • Politics • foxnews.com
Man falls to death during Goose concert at Madison Square Garden

A 51-year-old man is dead after falling from an upper tier of Madison Square Garden into a lower section during Saturday's Goose concert.

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Jun 21 • 11:32 AM EDT • Entertainment • ew.com
Health fair to provide wellness advice, vaccinations

The Healthways Alliance Community Health Fair 2026 runs from 11 a.m. to 2 a.m. on Saturday and will also feature a special keynote focused on diabetes awareness, education, and healthier living.

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Jun 21 • 10:44 AM EDT • Health • wane.com
Sen. Cory Booker says people should be ‘very worried’ about Trump and Israel upending peace in the Middle East

The New Jersey Democrat criticized President Donald Trump and Israeli Prime Minister Benjamin Netanyahu, calling them both “criminal” leaders.

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Jun 21 • 10:41 AM EDT • Politics • nbcnews.com
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Week in politics: continued negotiations with Iran; G7 summit; Reflecting Pool issues

There continues to be uncertainty over negotiations. At the same time, the Trump administration continues to aggravate allies.

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Jun 21 • 8:06 AM EDT • Politics • npr.org
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SC governor’s race gets the headlines. But there’s still a Statehouse session to finish.

While South Carolina’s political class are focused on the elections, legislators in the statehouse still have an active session to finish before calling it quits on 2026. Here’s what’s left to accomplish.

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Jun 21 • 6:00 AM EDT • Politics • postandcourier.com
How Trump’s Fragile Agreement With Iran Is Shaping the Midterms

Democrats say the president started an economically painful war that resulted in nothing positive. Republicans are more divided, even as they show some signs of relief at falling gas prices.

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Jun 21 • 5:02 AM EDT • Politics • nytimes.com
Peterson didn’t hesitate in calling James the GOAT

Peterson didn’t hesitate in calling James the GOAT

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Jun 21 • 2:23 AM EDT • Sports • sports.yahoo.com
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Chris 'The Bear' Fallica's World Cup Best Bets Today

Chris "The Bear" Fallica delivers his daily best bets for the World Cup. Here's what he's backing on Match Day 11.

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Jun 20 • 3:20 PM EDT • Sports • foxsports.com
Jim Cramer Says Clover Health Was a Good Speculative Pick But Still Prefers UnitedHealth and CVS

Clover Health Investments, Corp. (NASDAQ:CLOV) was among the stocks on Jim Cramer’s radar on Mad Money, as he advised investors to care about where a stock is going, not where it has been. A caller referenced Cramer’s previous comment, calling it speculative, and noted that the company reported GAAP profitability in Q1 2026 and guided […]

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Jun 20 • 9:39 AM EDT • Health • finance.yahoo.com