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Cubs Trade Of Edward Cabrera An Early Lose-Lose Deal
A high-stakes gamble for Edward Cabrera backfired in Chicago as the right-hander's metrics plummeted, leaving the North Siders searching for answers amidst a looming rotation crisis.
Politics Unplugged (Full Episode) Oct. 25, 2026
On this week's episode of Politics Unplugged, host Dennis Welch and a panel break down Arizona's election landscape one week out: pessimistic voter mood, suppressed independent turnout, lagging GOP enthusiasm, and Democrats gaining ground. They discuss Elon Musk's late spending in competitive House races and debate the impact of big money flooding the state. The show also covers a widely condemned Ohio attack ad by Vivek Ramaswamy that weaponizes a rival's childhood abuse—drawing praise from Trump and Vance but bipartisan outrage.
FL GOP Rep. Carlos Gimenez: I don’t want my children or grandchildren to face a nuclear Iran
Four Positives From Frustrating Start To New Orleans Pelicans Season
These are some of the biggest positives to take away from the first few games of the New Orleans Pelicans' season.
Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing
Peyton Manning is one of the greatest players, if not the greatest, to ever play for the Indianapolis Colts. The former quarterback is one of the most decorated players in American football history. He has won the Super Bowl two times, and is a five-time NFL Most Valuable Player. The Colts have not found the […] The post Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing appeared first on Gridiron Heroics.
Attackers kill nurse, severely injure health worker responding to Ebola case in eastern Congo
BUTEMBO, Congo (AP) — A nurse was killed and a health worker severely injured after being attacked while responding to an Ebola alert in Congo, according to the World Health
Innovative food processing technique boosts Nebraska companies, educational outreach
Leadership and strategic visioning by Mary-Grace Danao, research associate professor in the Department of Food Science and Technology and the Department of Biological Systems Engineering, has helped position the University of Nebraska–Lincoln at the forefront of high pressure processing-focused food safety research in partnership with private industry.
Gauging Global Access to Dermatology Care: Q&A With Esther E. Freeman, MD
Dermatologist and epidemiologist Esther E. Freeman discusses the Global Access to Skin Health Observatory Study and how its findings will hopefully help improve dermatology care worldwide.
Business is booming for Giacinta’s at the Bridge
BRIDGEPORT – Since welcoming Giacinta’s Gelato & Caffe to their new location in the multipurpose Bridge at Bridgeport Exempted Village School District, the place has been a go-to spot for students and community members looking for that morning pick-me-up. Owner Audrey Brahler made some time between morning rushes of buyers to talk about the success […]
Johnson & Johnson Deepens Hong Kong Commitment with Strategic Partnership to Accelerate Healthcare Innovation
Johnson & Johnson Deepens Hong Kong Commitment with Strategic Partnership to Accelerate Healthcare Innovation
Australian politicians pay tribute to wounded lawmaker
Australia's prime minister and fellow parliamentarians led sombre tributes Monday to "beacon of decency" and colleague Helen Haines, who remains in hospital after being struck by a car outside her off...
Ivica Zubac (left ankle sprain) will not return to …
Ivica Zubac (left ankle sprain) will not return to …
Trump invokes anti-Muslim rhetoric to attack El-Sayed at Port Huron rally
President Donald Trump has been telling crowds of supporters at rallies across the nation that they should vote in November as if he is on the ballot — a theme he invoked again in Michigan this weekend.
Thousands protest in Prague against public media funding reforms
Demonstrators allege Prime Minister Andrej Babis and his coalition's proposed reforms pose a threat to press freedom.
Elon Musk’s Grok Imagine Releases First Odyssey Episode With Wonder Studios
8 sources compared: Other (4), Western Mainstream (3), Latin American (1). Elon Musk’s Grok Imagine released the first episode of its AI-generated series “The Odyssey,” posting a seven-minute vid...
50 Cent Trolls Rick Ross After His Son's Alleged Attack
The rapper and entertainment mogul joked that he plans to bail out the suspect who allegedly assaulted Ross' son, William Roberts III.
Kyle Larson’s Championship Moment Comes at Talladega
Conquering his drafting-track demons, Larson surged from mid-pack chaos to secure a historic Hendrick 1-2 finish, building a massive points cushion that places the title within reach
Quinshon Judkins flirts with century mark in Week 7 return
Cleveland Browns running back Quinshon Judkins (ankle) rushed 17 times for 96 yards and two touchdowns in Week 7
6 stats from Barcelona 1-2 Real Madrid
A first away Clásico win in three years
“Odegaard was outstanding” but Merson was less complimentary about Gyökeres
Paul Merson has delivered contrasting verdicts on two Arsenal players following Saturday’s comfortable 2-0 victory over Everton, singling out Martin Ødegaard for praise while questioning Viktor Gy�...
Open Thread: Colorado Avalanche @ Nashville Predators (6:00 P.M. MDT)
Tonight is another Colorado Avalanche game day as they pay a visit to Nashville to face the Predators!
What’s going on with AJ Dybantsa’s ankle injury?
The Washington Wizards have started off playing well this season, and they’ve done so without the No. 1 overall pick. AJ Dybantsa hasn’t made his NBA debut yet as he deals with an ankle injury, and it looks like he’ll have to keep waiting after the latest update on his status, according to Brett Siegel of ClutchPoints. “AJ Dybantsa will remain […] The post What’s going on with AJ Dybantsa’s ankle injury? appeared first on ClutchPoints.
Try This If You Want To Stop Losing Your Roku Remote
Roku remotes have a way of disappearing just when you want to watch something. Before you pull the couch apart again, there's something worth trying.
Veteran Makers Market highlights importance of supporting veteran-owned businesses
The Veteran Makers Market spotlights veteran-owned businesses, encouraging shoppers to support those turning military skills into local success.
Raptors to miss Kawhi Leonard on Sunday night
The Raptors will be without a key piece of their lineup on Sunday night.
Matthew Stafford breaks Rams franchise record for touchdown passes
LAS VEGAS (AP) — Matthew Stafford added another milestone to his NFL career on Sunday, throwing his 155th touchdown pass for the Los Angeles Rams to break the franchise record.Stafford surpassed Roman Gabriel, who threw 154 TD passes for the Rams from 1962-72.
A new state on the way? More Illinois counties could vote to leave Chicago behind
More than 30 counties have already approved the non-binding measure to leave Illinois
Over 300 students learn science and technology at CCSD Family STEM Day
Over 300 students learned about science and technology industries at the Clark County School District Magnet Schools Family STEM Day on Saturday.STEM Day as he
Walnut Ridge business starts coat drive for community
The Farm Service Tire Center in Walnut Ridge is hosting its first-ever coat drive, running now through Dec. 21.
Ollie Gordon II surpasses 100-yard mark in Week 7
Dolphins RB Ollie Gordon II finishes with 103 rushing yards in Week 7 win
Nico Collins disappoints in Week 7 vs. Giants
Houston Texans wide receiver Nico Collins posted two receptions for six yards on five targets in Week 7
Peoria business leader accused of DUI in deadly UTV crash
A business executive well known in the local sport community has been arrested on drunk driving accusations for a crash that killed a woman late Saturday night in rural Peoria County.
Martin Short's Says His Countdown for Showbiz Sucess Was a Year With Social Work as Plan B
Orlando Magic's Sean Sweeney Message to Paolo Banchero After Injury
As a grueling road trip looms, assistant coach Sean Sweeney challenges his squad to maintain their identity and intensity while navigating Paolo Banchero’s absence against elite competition.
Oregon State gains ground in AP poll after bye week
The Beavers gained votes in the AP poll, but dropped in the coaches poll.
Clemson’s Loss to Virginia Tech Puts the Program in Flux
Clemson’s loss to Virginia Tech puts the program in flux heading into November. The Tigers now find themselves on the outside looking in on the ACC Championship race after being defeated 20-16 by the Hokies. Dabo Swinney’s team played well in many spots, especially in the third quarter. The complementary football Clemson displayed to start the …
T.J. Hockenson finds end zone in Week 7 vs. Colts
Minnesota Vikings tight end T.J. Hockenson posted four receptions for 35 yards and a touchdown on five targets in Week 7
U.S. measles cases more than double what they were last year as outbreak spreads
Pennsylvania is the worst hit state, with at least 1,338 cases of measles confirmed in 44 counties so far this year, according to the Pennsylvania Department of Health.
Brad Pitt's Underrated Sci-Fi Astronaut Movie Deserved Better At The Box Office
You likely missed this critically acclaimed Brad Pitt sci-fi thriller when it was in theaters, but it's a film that warrants a watch.
When will Myles Garrett return to the Rams?
Here's the latest on Myles Garrett as he continues recovering from early-season knee surgery.
Is the Big 12 a two-bid CFP league? + 2-loss SEC playoff hopes + Lincoln Riley’s future at USC
Cavs vs. Timberwolves: How to watch, odds, and injury report
The Cavs will welcome the surging Timberwolves to town.
Two Georgia Bulldogs ranked among college football's top-25 players
Two Georgia Bulldogs earned top-15 spots on ESPN's midseason top 25 college football player rankings.
Des Moines bishop says White House 'exploited' visit for politics
Bishop William Joensen was one of several invited to the White House for a private meeting they say is being used for "partisan political purposes."
The Politics of Heaven ~ The Imaginative Conservative
The key to understanding Thomas More’s generous dedication to the real but limited good he could do on earth is, as Frank Mitjans makes clear, that More’s constant contemplation of God was the source of his boundless care for the souls surrounding him. Thomas More’s Vocation, by Frank Mitjans
When will Jeremiyah Love return to the Cardinals?
Here's the latest on Jeremiyah Love's status for the rebuilding Cardinals.
Why is the U.S. accusing Canada of election interference?
the U.S. Embassy accused Canadian officials of meeting with Democratic lawmakers, urging the use of retaliatory levies to hit Republican states, and running anti-tariff political advertising.
NZ’s hidden chronic health burden is even bigger than we thought
New research reveals a major gap in how chronic illness is measured, with implications for planning and funding healthcare in New Zealand.
Editorial: Company mergers are causing more harm to the entertainment industry than good
Two weeks ago, Paramount officially completed its $110 billion purchase of the historic Warner Bros.
Halloween evolved as a Frankenstein of cultural celebrations
The holiday has origins in Celtic, Roman and Catholic festivals and feasts, and mixed with other traditions as it spread.
Ravens lose standout rookie to injury against Bengals
The Baltimore Ravens have lost a key rookie to injury, forcing another change up front against the Cincinnati Bengals.
Nets' Second-Year G Dëmin Bounces Back Against Cavaliers
The Brooklyn Nets got a much-better performance from second-year BYU product Egor Dëmin against the Cleveland Cavaliers. With Mikel Brown Jr. on a minutes restriction, Dëmin needs to play a big role.
“Business as usual” – PSG coach refuses to give his players an excuse after triple blow
PSG are missing some important players, but that’s not an excuse says manager Luis Enrique, who still expects the best.If you enjoy PSG Talk coverage and want to see more of it, add us as a preferre...
Nigeria widens hunt for possible Ebola cases
Nigeria has widened a hunt for potential Ebola cases, with an additional nine contacts traced, health authorities said Sunday.The initial 44 contacts were health care workers, while the additional nin...
The Future of IBD Treatment: 4 Promising Therapies to Know About
New treatments are in development for inflammatory bowel diseases like Crohn’s disease and ulcerative colitis. Find out what experts say you should know.
Texas makes big moves in both polls
The win over the Rebels vaulted the Longhorns in the AP Top 25 and Coaches Poll.
Ramaswamy built his political career in NH. It's faltering in Ohio.
Many New Englanders remember Ramaswamy from his mad-dash presidential campaign in New Hampshire. Will his political career survive a tumultuous run for Ohio governor?
Olympiacos May Attempt to Sign Genoa Midfield Maestro This Winter
Olympiacos are poised to reignite their pursuit of Morten Frendrup, testing Genoa's resolve after a rejected summer bid for the consistent Danish engine room specialist.
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine
Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria contracted Ebola.
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine
Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria cont...
Steelers stock report after Week 7 win over Saints
Stock up, stock down, after the Steelers Week 7 win in Paris over the New Orleans Saints.
COMMENTARY: Three reasons why Tennessee football imploded against South Carolina
Penalties, brain blips and a hangover conspire to doom Volunteers.
Projections for Cleveland Guardians’ Arbitration Eligible Players
The Cleveland Guardians have several key players arbitration-eligible this offseason.
Sunday Open Thread
There is no Jays news and I’ve got nothing to talk about, so lets have an open thread. We had the second great World Series game in a row last night. I like watching baseball (or any sport) when I have no rooting interest. After a season of caring about every Jays game, I like […]
Nico Williams publicly disavows his agent over Barcelona transfer claims
Barcelona’s long and drawn-out pursuit of Nico Williams has become one of the more familiar sagas of recent transfer windows.The Athletic Club winger ultimately opted to stay at San Mames, snubbing ...
'You Can See Everything' Surges With $19.5M at Box Office; 'Clayface' Takes No. 1
NEW YORK (AP) — DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s Elizabeth Holmes documentary “You Can See Everything,” which pulled in $19.5 million in its ...
Lady Gaga dancer reveals why he thinks she’ll succeed at motherhood
Lady Gaga’s backup dancer, who slid off stage mid-performance during last year’s Mayhem Ball world tour, is opening up about why he believes the singer will succeed at motherhood.
Steelers beat Saints to win first NFL game in Paris
The Pittsburgh Steelers defeated the New Orleans Saints 16-10 on Sunday to win the first-ever NFL regular season game in Paris. The low-scoring game had only one touchdown for each team.
This Switch 2 sequel accessory was a few millimeters away from being good
The right stick gets in the way.
Oregon fires offensive coordinator Drew Mehringer after team scored just 10 points in loss to Illinois
Saturday's loss marked the third straight game in which Oregon scored under 20 points.
Aaron Rodgers throws for 212 yards in Week 7
Steelers QB Aaron Rodgers sees multiple TD streak snapped in Week 7 win
😱Fans back Carrick: How the United players left
Today, Manchester United suffered another crushing defeat, losing 0-3 to Bournemouth at Old Trafford. There was plenty of talk during the week about the rift between the players and Michael Carrick, p...
Saints Lose Defensive Battle in Paris Against Steelers
A very winnable game that a better team would have won.
Orlando Science Center hosts Halloween party
Adults can enjoy an open bar, laser shows, and more at the Orlando Science Center's Halloween After Dark on October 31.
Lakers 1st-Round Draft Pick Floated as Trade Piece
The Los Angeles Lakers are off to a fast start. Could it be time to weigh trading away some young pieces to boost the rotation? The post Lakers 1st-Round Draft Pick Floated as Trade Piece appeared first on HEAVY.
Health care shakes up the Iowa election
If Democrats flip Congress, health care could find its way to the top of their 2027 agenda.
Opposition leader María Machado returns to Venezuela
Machado had left the country just a month before the US government seized Venezuelan President Nicolás Maduro.
Data center boom sparks massive power line fights hundreds of miles away
In Cat Kemmerling’s dream, she and her husband Rob are sitting in their pickup truck on a cliff on their West Virginia farm, overlooking the Shenandoah River. The truck is falling backwards over the edge, into the abyss below.
Is having urine the color of Mountain Dew normal?
A Trump administration doctor says neon yellow urine is normal because of diets consisting entirely of meat and fermented foods. Here’s what experts say
Americans have a grief problem we still call a mental health problem
OPINION — Americans have become much better at talking about mental health. We have learned words such as trauma, post-traumatic stress disorder, depression, anxiety, burnout, compassion fatigue and moral injury. That vocabulary matters.
Browns Week 7 inactives: Who's in, who's out?
The Browns are the healthiest they have been in some time as they take on the Titans in Week 7.
Republican responds to AI video in Fort Bend County political battle
Fort Bend County has seen plenty of controversy at its highest levels.
2 political experts question Chicago Mayor Brandon Johnson's tax proposals for 2027 budget
Liverpool 2, Brighton 0 – Match Recap: That Was Actually Fun
A look back at the key moments in Liverpool's great victory over Brighton in Premier League action.
Scientists Discover a Plant Compound That Could Help Stop Rheumatoid Arthritis Inflammation
Scientists have identified a plant compound that reduced joint swelling and inflammation in rats with experimental arthritis. The discovery offers a potential new direction for rheumatoid arthritis tr...
Obama and Trump wage one last battle for even more urgent stakes
Two decades ago, Barack Obama stormed battleground states rebuking a Republican president over a deeply unpopular war and an economy that was crushing working Americans.
Chivu: “The boys gave everything right to the end”
Cristian Chivu wasn't the only one who couldn't bear to watch Zielinski's decisive penalty. The Inter coach bent over on the touchline, looking away as the midfielder stepped up to take it. When the b...
How Braves should handle $42 million Jurickson Profar situation
This could be one solution for the Braves.
Packers Lose Defensive Captain Just Before Massive Showdown With Lions
Green Bay Packers defensive captain Zaire Franklin has been ruled out against the Detroit Lions, leaving Green Bay without both starting linebackers.
How Nathan Fielder's cringe-comedy career led him to Elizabeth Holmes
Spoiler alert! We're discussing the themes and structure of the Elizabeth Holmes documentary "You Can See Everything" and touching on a surprising aspect of its second half, so turn away if you want to go in completely cold.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.