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Defender turns striker and scores in Bayern win
Bayern Munich beat Freiburg 3-1 away from home to reclaim top spot in the Bundesliga on Sunday (25).Dayot Upamecano was one of the standout performers, scoring the opener with a move in which he playe...
Nigeria widens hunt for possible Ebola cases
Nigeria has widened a hunt for potential Ebola cases, with an additional nine contacts traced, health authorities said Sunday.The initial 44 contacts were health care workers, while the additional nin...
Ramaswamy built his political career in NH. It's faltering in Ohio.
Many New Englanders remember Ramaswamy from his mad-dash presidential campaign in New Hampshire. Will his political career survive a tumultuous run for Ohio governor?
Board of Deputies of British Jews declares Greens to be racist party
The Jewish body's vote comes in response to the Green Party passing a "Zionism is racism" policy motion.
Made in Tarrant: Family turns sports card hobby into baseball stadium business
Rebecca Gallagher and her family opened their business in Choctaw Stadium in Arlington a few weeks ago. They hope it can grow into a place for community.
Made in Tarrant: Family turns sports card hobby into baseball stadium business
Rebecca Gallagher and her family opened their business in Choctaw Stadium in Arlington a few weeks ago. They hope it can grow into a place for community.
Blanche defends DOJ lawsuit blocking Alaska Senate results if Republican loses
Attorney General Todd Blanche defended the Justice Department's suit over Alaska's Senate race in an interview on CNN.
Knicks Have Clear Advantage Over Magic With Lopsided Injury Report
The New York Knicks look for their first win of the season.
Projections for Cleveland Guardians’ Arbitration Eligible Players
The Cleveland Guardians have several key players arbitration-eligible this offseason.
Scientists Discover How Excess RNA Can Disrupt the Energy Supply Inside Cells
Scientists at Texas A&M University discovered that excess RNA can interfere with the machinery cells use to produce energy, even without triggering certain immune defenses. The findings reveal an unex...
Nico Williams publicly disavows his agent over Barcelona transfer claims
Barcelona’s long and drawn-out pursuit of Nico Williams has become one of the more familiar sagas of recent transfer windows.The Athletic Club winger ultimately opted to stay at San Mames, snubbing ...
Carrick ‘not expecting’ Man United crisis talks despite Bournemouth defeat
Michael Carrick said he is ‘not expecting’ imminent talks about his future despite Manchester United’s latest defeat.Carrick’s position as head coach looks under threat after Manchester United...
Oregon fires offensive coordinator Drew Mehringer after team scored just 10 points in loss to Illinois
Saturday's loss marked the third straight game in which Oregon scored under 20 points.
Broncos Place Linebacker, Running Back On Injured Reserve
The Denver Broncos have a fluid injury situation, with Tyler Badie and Jonah Elliss being placed on injured reserve.
😱Fans back Carrick: How the United players left
Today, Manchester United suffered another crushing defeat, losing 0-3 to Bournemouth at Old Trafford. There was plenty of talk during the week about the rift between the players and Michael Carrick, p...
Police: Lancaster County health care worker assaulted
Incident occurred at WellSpan Hospital in Ephrata Borough, according to police.
Orlando Science Center hosts Halloween party
Adults can enjoy an open bar, laser shows, and more at the Orlando Science Center's Halloween After Dark on October 31.
Opposition leader María Machado returns to Venezuela
Machado had left the country just a month before the US government seized Venezuelan President Nicolás Maduro.
Kansas at Duke: Exhibition OGT
Kansas basketball hopes to follow the football team with a win today. Yeah, this game doesn’t count, but any time you’re playing Duke you want to win. Plus, this exhibition game is a big enough deal that ESPN is broadcasting it live (probably because they know everyone else will be watching football. I’m probably going […]
Buccaneers vs. Panthers Week 7 inactives: Baker Mayfield returns
The Tampa Bay Buccaneers are set to take on the Carolina Panthers Sunday afternoon in a crucial NFC South matchup at Bank of America Stadium in Charlotte. Tampa Bay received some encouraging news ahead of kickoff as quarterback Baker Mayfield is officially active and will start after missing the previous three games with a dislocated […]
Baltimore Ravens vs. Cleveland Bengals Week 6 game discussion
Join the discussion about the Ravens’ Week 7 matchup with the Bengals!
Game Time Thread: Juventus vs. Lecce
MATCH INFO When: Sunday, Oct. 25, 2026. Where: Stadio Via del Mare, Lecce, Italy. Official kickoff time: 6 p.m. local time in Italy and across Europe, 8 p.m. in the United Kingdom, 1 p.m. Eastern time, 12 p.m. Central time, 10 a.m. Pacific time. (Please note that the fall time change in Italy goes into effect on Sunday, […]
How Braves should handle $42 million Jurickson Profar situation
This could be one solution for the Braves.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
During the hike, participants wore military short-shorts known as “silkies” as part of the event’s tradition to foster connection.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
Veterans, active military service members and community supporters recently gathered for a hike organized by a nonprofit dedicated to suicide prevention.
Who can buy California's voter rolls and why?
Chris Micheli, an adjunct professor at McGeorge School of Law and longtime lobbyist, explained who is able to buy the voter rolls and why in an interview on California Politics 360.
Mystery Ohio news site boosting Ramaswamy's Amy Acton ad tied to California GOP non-profit
As Ohio Republican gubernatorial candidate Vivek Ramaswamy came under fire for releasing an attack ad featuring his Democratic competitor Amy Acton's estranged mother, a mysterious news site was runni...
Modders Unlock GeForce RTX 20, 30 And 40 GPUs For Up To 2X Compute Gains
The compute barrierbbetween NVIDIA RTX Pro GPUs and NVIDIA GeForce GPUs has finally been breached.
Aaron Rodgers throws 540th career touchdown, passing Peyton Manning on all-time list
Aaron Rodgers now sits third all-time in passing touchdowns.
Scientists Find Chronic Back Pain Activates a Brain Network Linked to Personal Identity
A new UC San Diego brain imaging study involving 114 adults suggests that chronic back pain flare-ups affect brain networks involved in self-reflection and personal memories. The findings may help exp...
Aaron Rodgers passes Peyton Manning on all-time touchdowns list
Aaron Rodgers surpasses Peyton Manning in all-time touchdown passes.
Babcock Singles Out Oiler After Ugly Loss To Maple Leafs.
Mike Babcock called out one player in particular after a 7 - 2 thrashing against the Leafs.
Mavericks 'Very, Very Confident' in Rookie PG Behind Kyrie Irving
Spanish sensation Sergio de Larrea shined with 21 points against San Antonio, proving he can anchor the rotation while Dallas carefully manages Kyrie Irving’s heavy workload.
10 Thoughts From Watching Others Sweat It Out
Back during the very lean years of the Ray Goff era in Athens, a certain revered columnist for the Macon Telegraph joked in a weekly prediction column that Georgia would lose to “Open” during its upcoming bye week. Thankfully, those years have passed by, and the outlook for Georgia during open weeks for what is […]
NFL Trade Deadline Could Dramatically Change The AFC South Landscape
With top stars from the Titans, Colts, and Jaguars hitting the trade block, Houston’s rivals could strip their rosters of veteran talent to fuel a mid-season rebuild.
Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks
The Boston Celtics beat the New York Knicks 107-103 on Friday night at TD Garden. Jayson Tatum scored 36 points and closed the game with a run that sealed the win. The stat line told the obvious story.But after the game, the moment Tatum wanted to talk about was not one of his own. It […] The post Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks appeared first on HEAVY.
Oprah on the Health Metric We Should All Be Tracking
“These facts are a wakeup call for all of us to get serious about our heart health.”
Instacart Stock What Health Benefits Deal And $5 Million Settlement Mean
Instacart parent Maplebear has agreed to a US$5,000,000 settlement with U.S. authorities over past PERM hiring practices and has been selected by True Rx Health Strategists to power an employer funded healthy food benefit through Instacart Health Fresh Funds starting in 2027. The True Rx program positions Instacart within pharmacy benefit design and ties employer spend directly to clinically supervised food choices. The settlement adds compliance obligations, policy changes and monitoring...
Can social media bans protect young people’s mental health? Early research suggests that bans aren’t the answer
About 20 countries are looking to ban minors from social media. But bans have not always worked as planned. Here are some other ideas to make platforms safer for kids.
Silicon Valley software engineer pay ranked against other US cities
Bay Area software engineers retain a 53% pay premium after adjusting for local prices, Levels.fyi found. Taxes aren't included.
Nuthatches are rude: Ornithological observations from a recliner
I don’t know what age you’re supposed to start sitting in a recliner and looking out the living room window at the bird feeder, but I sure do like doing
Nick Nurse: “Jaylen Brown is obviously very good. He …
Nick Nurse: “Jaylen Brown is obviously very good. He …
Khaman Maluach: “It’s different. Draymond Green is …
Khaman Maluach: “It’s different. Draymond Green is …
"Jakucionis, he's family. He's an incredible player," …
"Jakucionis, he's family. He's an incredible player," …
Maliek Collins agrees to terms on contract extension
Maliek Collins to remain in Cleveland for two additional years
Hints About Why Sabres Missed Connor Hellebuyck
The fact that the Buffalo Sabres missed out on Connor Hellebuyck could linger painfully for a while if the goalie play in Western New York doesn’t improve in a hurry. It’ll hurt all the more because the reports over the summer indicated that for at least a time, the Sabres were the frontrunners to pull […] The post Hints About Why Sabres Missed Connor Hellebuyck appeared first on HEAVY.
Crystal Palace v Chelsea
Follow live text commentary, score updates and match stats from Crystal Palace vs Chelsea in the Women's Super League
Health board still paying for research despite criticism over patient benefit
Betsi Cadwaladr health board was due to pay Bangor University £110,686 for two researchers.
Health board still paying for research with 'unclear' patient benefit
Betsi Cadwaladr health board was due to pay Bangor University £110,686 for two researchers.
NFL Week 7 expert picks, score predictions: Packers at Lions
Green Bay Packers vs. Detroit Lions NFL Week 7 expert picks from the Pride of Detroit staff.
Argument over purchase turns physical; suspect pulls gun at South Side business
KABB Fox News 29 San Antonio provides local news, weather forecasts, traffic updates, investigations, notices of events and items of interest in the community, sports and entertainment programming for San Antonio and nearby towns and communities in South Central Texas, including Bandera, Boerne, Carrizo Springs, Castroville, Cibolo, Converse, Crystal City, Cuero, Del Rio, Devine, Eagle Pass, Floresville, Fredericksburg, Goliad, Helotes, Hondo, Kerrville, Live Oak, New Braunfels, Pearsall, Pleasanton, Poteet, Poth, Sabinal, San Marcos, Seguin, Schertz, Somerset, Universal City, Uvalde, Windcrest.
Appleton-area high school sports results for Saturday, Oct. 24
High school tennis, volleyball, soccer and cross-country teams were in action.
Indiana football should be better. It also could be worse
On one hand, Indiana hasn’t played its best football in weeks. On the other, neither has anyone else, really.
Full injury report for Sunday's Clippers vs. Thunder matchup
Full injury report for Sunday's LA Clippers vs. Oklahoma City Thunder matchup.
Guardians Middle Infielder is a Prime Trade Candidate
The Cleveland Guardians, fresh off an ALCS appearance, will be facing several tough decisions next season regarding their lineup. The 85-win team won their division and looks poised to repeat next year, but they face an enviable dilemma. What do they do with their influx of top, young talent, and how do they find them …
Birmingham City v Charlton Athletic
Follow live text commentary, score updates and match stats from Birmingham City vs Charlton Athletic in the Women's Super League
Mark Allen 'completely overwhelmed' after opening up about mental health
The snooker player has given fresh hope that he may return to competition
Pat Surtain II unlikely to play
Pat Surtain has good chance to suit up in Week 8 due to ankle injury
After win over Ole Miss, Texas QB Arch Manning says that he 'kind of likes being disregarded'
McMillan backs Coombes after groin grab allegation
Munster head coach Clayton McMillan backs Gavin Coombes after the back row alleged he had been grabbed in the groin in Saturday's defeat by Leinster.
She voted for Trump every time. Then came cancer and the bills
Cindy Banda faces mounting medical bills after battling breast cancer. Despite the single mother's positive outlook, the financial strain combined with the high cost of living is overwhelming. And it's
AI in policing risks deepening discrimination, research warns
AI tools learn from biased records and may deepen discrimination against minorities without oversight, researchers say.
Week 7 inactives for Saints
New Orleans declares seven players inactive versus Pittsburgh
Arsenal squad & fixtures for the 2026 Messi Cup
The 2026 Messi Cup kicks off on Sunday, with Arsenal’s squad and fixture list for the tournament now confirmed.Photo by Elsa/Getty ImagesThe Arsenal u16s will take part in the Messi Cup this year, w...
Bill Belichick speaks on loss to Syracuse
What Bill Belichick said after UNC football lost to Syracuse.
The top 25 classic golf courses in Canada, ranked
We rank the best courses built in Canada before 1960.
Interest rates unlikely to reach 4.75% by next summer, say City economists
Experts say Bank of England unlikely to increase rates by full percentage point – and could lower them by end of 2027
The Health Benefits of Blueberries—and the Best Ways to Eat Them
Are blueberries good for you? Experts share the health benefits of these popular berries. Plus, discover what to look for when buying blueberries, the best way to store them, and how to use blueberries in your food and cooking.
Game status update for Browns CB Denzel Ward against Titans
Cleveland gets an update on the status of their top cornerback.
Svilar eyes return from injury vs Manchester United
Gian Piero Gasperini can hope for a return to goal for his regular starter before the new international break. According to Riccardo Trevisani on Radio Manà Manà Sport Roma, Mile Svilar could recove...
South Texas Health System (@stxhealthsystem)
2 likes, 1 comments - stxhealthsystem on October 25, 2026: "One Last Chance to Think Pink: Breast cancer remains the most common cancer among women after skin cancer, making routine screenings and early detection more important than ever. Mammograms can help identify breast cancer before symptoms appear, when treatment options may be most effective. Last week, South Texas Health System McAllen celebrated breast health and preventive care with a special Mammo Monday event featuring the vibrant sounds of mariachi music at the hospital’s main entrance. The celebration reflected STHS' ongoing commitment to encouraging women to prioritize their health through regular screenings. Now, there’s one final Mammo Monday remaining! Join us at STHS ER Mission on October 26 from 8 a.m. to 5 p.m. for the last breast cancer event of 2026. During the event, attendees can: 🎀 Learn about breast cancer screening options 🎀 Schedule a mammogram appointment 🎀 Receive a complimentary goodie bag while supplies last To help make preventive care more accessible, South Texas Health System is also offering reduced self-pay rates* throughout October: • 2D Mammogram: $100 • 3D Mammogram: $155 • Bone Density Screening: $160 A screening today could make all the difference tomorrow. Make your health a priority and encourage the women you love to do the same. For breast health resources and information on the Think Pink campaign, visit the link in our bio. *If not already a covered benefit of your insurance.".
I'm a Dietitian, and This Is What I Tell People Who Drink Diet Soda Every Day
A registered dietitian explains what the research says about diet soda and artificial sweeteners, from weight and blood sugar to gut and heart health.
2 reasons Colts can upset Vikings in Week 7 matchup
Former NFL coach Jon Gruden predicts the Colts will upset the undefeated Vikings, with ESPN analyst Seth Walder also backing Indianapolis.
WSL: Crystal Palace host Chelsea in first of five games
Follow live coverage of Crystal Palace host Chelsea in the first of five Women's Super League games on Sunday.
College football scores yesterday: Results of top 25, notable games
More ranked teams lost to unranked foes in Week 8. Here are the scores from top 25, other notable matchups that took place in Week 8.
Former Minecraft lead, Xbox veteran and COO Helen Chiang "fired" for "policy violations"
A new report suggests that Helen Chiang, recently appointed as Xbox Chief Operations Officer, was terminated for "policy violations," although there's no word on exactly what.
College football rankings after Week 8: Updated Coaches Poll, AP Top 25 for SEC
Here's where SEC teams were ranked in the latest US LBM Coaches Poll and AP Top 25 after Week 8:
Updated SEC football conference standings following Week 8 upsets
The SEC's Week 8 slate produced a number of notable results. Here is how those results impacted the conference standings entering Week 9.
The top 25 modern golf courses in Canada, ranked
Our ranking of top modern Canadian courses returns, with Nos. 1 and 2 sitting side by side.
Health Experts Reveal The 1 Thing They Wish Their Older Patients Would Do
Here are a few small ways to do yourself some major favors, from pros like cardiologists and nutritionists.
Woman Is Quoted $2K to Put Up a Flex Wall in N.Y.C. Apartment, So She Uses Plastic Building Blocks Instead (Exclusive)
“I really grew to love my little castle,” Alliyah Barre tells PEOPLE
How to Watch: Arizona Cardinals vs. Denver Broncos
Everything you need to know about the Arizona Cardinals game against the Denver Broncos.
New York Giants activate Paulson Adebo; elevate Jalin Hyatt
The New York Giants have made a series of roster moves, including the activation of CB Paulson Adebo and the elevation of WR Jalin Hyatt.
Is it rude to keep the airplane window shades open?
In this Sunday edition of Business Insider Today, we're breaking down the flight etiquette debate that's dividing the internet.
Why Mikel Arteta is right about Max Dowman
Mikel Arteta has faced some pushback on his recent comments about Max Dowman, but the Arsenal manager was right to suggest that what the 16-year-old is doing is unique.Photo by Julian Finney/Getty Ima...
Colts Make Roster Moves Ahead of Sunday's Matchup
The Indianapolis Colts made roster moves ahead of Sunday's matchup against the Minnesota Vikings.
Udinese vs AC Milan – Match preview and team news
AC Milan will aim to get inside the top four of the Serie A league table by securing all three points when they meet Udinese on Sunday away from home in their next match.Udinese vs AC Milan – Match...
Madison Ballet makes 'Jekyll & Hyde' a psychological thriller
The ballet's world premiere of 'Jekyll & Hyde' runs Oct. 30-Nov. 1 in the Starlight Theatre at MYArts, with more dancing than grisly murder.
Islanders Gameday News: Starting in Dallas; Hellebuyck moves next door
The Islanders have touched down in Dallas for a Sunday night encounter, where Pete DeBoer will be the story as he faces his most recent former team. The Stars are in their 1980s Capitals era (or more generously, 1980s Flyers), perennially fielding really good teams but finding different reasons and divine interventions to prevent their […]
As vote nears, Trump’s AI gamble fuels economic uncertainty
Some of the world’s leading financiers are sounding increasingly alarmed about an AI bubble.
Gov. Meyer announces the inclusion of the Verizon BEAD Project
Governor Matt Meyer announced the addition of the Verizon Broadband Equity, Access, and Deployment (BEAD) project to the JobsFirst Accelerator program.
“I’m not making this game about the officials so …
“I’m not making this game about the officials so …
Norman Powell: "I feel like this is another …
Norman Powell: "I feel like this is another …