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World Cup RO16: Paraguay vs France
Paraguay and France meet in a crucial round of 16 clash on Saturday with Didier Deschamps’ men looking to continue their goalscoring form and become the first team to score three or more goals in si...
"I Almost Left Sony Over That One" - Meet The Unreleased PlayStation Pad With A PS1 Inside
"Sony licensing couldn't get their act together about the royalty terms"
5 Small Business Ideas for Introverts
Prefer working solo? These small business ideas for introverts let you focus on creativity and deep work—and reduce meetings.
Colorado Politics Calendar July 6-12
CoPo’s weekly political calendar helps you find political and public policy events throughout Colorado. It includes candidate and issue campaign events, public policy meetings, court hearings, state and local party conventions, assemblies, debates, rallies, parades, speaking engagements, traveling dignitary appearances, water meetings, book signings, county commission hearings, city council meetings and more. As a subscriber, […]
World Cup Day 24 What to Watch: Kylian Mbappé, France in action; Canada, Morocco meet as Round of 16 kicks off
Gov. Wes Moore on ‘responsibility’ to show ‘patriotism is not political’
Gov. Wes Moore (D-Md.) joins Meet the Press NOW to preview his upcoming address on America’s 250th birthday as President Trump prepares to deliver his own remarks.
Meet Miss Washington USA Carisa Erickson, mom of 3 and mental health advocate
KOMO 4 TV provides news, sports, weather and local event coverage in the Seattle, Washington area including Bellevue, Redmond, Renton, Kent, Tacoma, Bremerton, SeaTac, Auburn, Mercer Island, Bothell, Shoreline, Lynnwood, Mill Creek and Everett.
Bernie Sanders says US is on the 'verge of a political revolution'
Meet Challenger, the legendary 35-year-old bald eagle making a special appearance to celebrate America's 250th anniversary in Washington, D.C., as military aircraft stage a thunderous dress rehearsal overhead.
Dodgers notes: Kyle Tucker, Dalton Rushing, Roki Sasaki
Outside of a measly one-run showing on Wednesday in Sacramento, the Dodgers offense has been rolling over their last six games. Against the San Diego Padres on Thursday, they overcame a six-run deficit while tying a season-high with 17 hits in a 12-7 victory, marking the second time over their last three meetings that the […]
Meet Melissa Rutland, the Republican running to flip HD 60 with a pledge that 'solutions aren't partisan'
The battle to replace Democrat Lindsay Cross is likely to be one of the toughest this cycle.
Richard Hughes has the perfect midfield signing for Liverpool
Liverpool's midfield is one of their main areas that needs to be revamped. Alexis Mac Allister and Ryan Gravenberch both failed to meet expectations last term with their inability to run one of their ...
From chasing titles to building businesses: Tennis legend Rafa Nadal on his next act
From chasing titles to building businesses, 22-time Grand Slam champion Rafa Nadal speaks to CNBC’s Tania Bryer about retiring from professional tennis, his new chapter as an entrepreneur, and measuring success without trophies.
Ron Perlman & Teri Polo Set For Archstone Entertainment Pic ‘Lies We Follow’
EXCLUSIVE: Hellboy actor Ron Perlman and Meet the Parents franchise actress Teri Polo are set to headline Aida Gevorgyan’s Lies We Follow which will be shooting in Los Angeles. In the pic, Jamie, a de...
Thousands need medical attention from ‘already overwhelmed’ Venezuelan healthcare system: Aid worker
Claudia Manresa, Venezuela Regional Manager at Project HOPE joins Meet the Press NOW to discuss the urgent humanitarian situation following last week’s twin earthquakes and the strain the disaster is putting on the country's already struggling systems.
Negotiations between Cherriots, business leaders paused after months of meetings
Talks between the Salem Area Mass Transit District and representatives from a coalition of six business and real estate groups, and citizens were halted last week, Cherriots said in a press release. The two groups formed a task force to find a compromise after a proposed payroll tax sparked frustration last year. To comment on this story, use the form at the end of the report.
Meet the Fort Worth Star-Telegram’s new entertainment reporter, Brayden Garcia
North Texas has a seen an explosion in film and television production over the last few years, and Brayden is here to report on it for Fort Worth.
Meet Meta's new vibe-coding app: Pocket
Pocket is a new app from Meta that lets you create and share interactive content, like mini games, with friends. It's powered by Meta's AI.
Meet Meta's new vibe-coding app: Pocket
Pocket is a new app from Meta that lets you create and share interactive content, like mini games, with friends. It's powered by Meta's AI.
Wolverhampton food and entertainment site plans to be discussed
Wolverhampton council’s cabinet will meet after £5.5m was set aside for the project this year.
Family business opens state's first solar-powered manufacturing facility
Meet the under-the-radar family business that today opens the state's first solar-powered manufacturing facility.
France Politics
France's President Emmanuel Macron chairs the fifth follow-up meeting on combating drug trafficking, at the Elysee presidential Palace in Paris, Thursday July 2, 2026. (Simon Wohlfahrt/Pool Photo via AP)
City Council Business Meeting on Tuesday, July 7, 2026, at 6:00 p.m.
The Palm Coast City Council meets regularly to discuss and vote on official City business. These meetings are open to the public, and Palm Coast residents are strongly encouraged to attend. An increase in public engagement helps to build a stronger sense of community, increase valuable discussions, and decrease division.
UToledo Health Pharmacy Residency Program Awarded Competitive National Grant
A $25,000 ASHP Foundation grant will grow UToledo's PGY1 Pharmacy Residency Program to seven residents, helping meet growing demand for pharmacist-led patient care.
Spain vs Austria – Match preview and team news
Spain and Austria meet in their Round of 32 fixture on Thursday at the Los Angeles Stadium.Spain are yet to concede a single goal at the World Cup and remains only one of two teams who kept a clean sh...
WHO, Member States discuss expanding South-East Asia Emergency Health Fund SEARHEF
With climate-related disasters, disease outbreaks and other health emergencies becoming more frequent and complex across South-East Asia, WHO and Member States today discussed measures to strengthen and expand the South-East Asia Regional Health Emergency Fund (SEARHEF) to ensure countries have rapid access to life-saving support when crises strike. "Health emergencies are becoming more frequent, more complex and more costly. Countries need rapid, flexible financing that can be mobilized immediately when lives are at risk. SEARHEF represents regional solidarity in action, enabling Member States to support one another when emergencies strike," said Dr Catharina Boehme, Officer-in-Charge WHO South-East Asia Region. She was addressing the Fifteenth Meeting of the Working Group on the Governance of SEARHEF.
British Business Bank bolsters board with four new directors
The British Business Bank has appointed four new non-executive directors across its boards, effective July 1, as chair Stephen Welton CBE is confirmed for a second three-year term
Politics complicate push for year-round E15, Iowa Farm Bureau president says
Questions loom over the status of E15 legislation in the U.S. Senate. “Mixed signals is very accurate.” Iowa Farm Bureau president Brent Johnson says he’s heard members of Congress say E15 can’t pass on its own, while others say it can. “So when you look at the makeup of the Senate, I do think we […]
Students Explore Science And Research At Fourth Annual Discovery Day
Local students joined Cincinnati Children’s Discovery Day to explore research labs, meet scientists, and learn about careers in science and medicine.
Business group shares parking plan concerns
Upcoming parking changes were the focus of a meeting between local business owners and representatives and city officials on Tuesday at the Marigold Bistro. Attendees asked questions and raised concerns about the plan, which takes effect today, July 1.
Tina Peters visits President Donald Trump in the White House
Since her release from prison, Tina Peters has reemerged on the political circuit — appearing over the weekend at the GOP Freedom Fest in Castle Rock and then visiting the White House on Monday to meet with President Donald Trump. In a post on Truth Social, Trump wrote that Peters “just came to the White […]
Sewerage and Water Board meet with Decatur businesses to answer questions about project completion
The floor was open for questions at Turtle Bay, where owners and employees pressed SWBNO about when the barricades will come down.
Not a rerun: This big name in American news is returning to television
Luke Russert, Tim Russert's son, is returning to TV. The format made his "Meet the Press" father famous. What
Atlanta Falcons Players Meet With Fans, Tour Zama During USO Visit
CAMP ZAMA, Japan - Members of the Atlanta Falcons spent time with Soldiers in Camp Zama’s Better Opportunities for Single Soldiers program, or BOSS, Jun...
Small Businesses Snagged $273 Billion In Federal Contracts, Even As Thousands Continue To Leave Contracting Base
Even as the government meets its goals in working with small businesses, a concerning trend appears to be accelerating.
Public Health steps up to meet community needs
Public Health continues to increase its presence in the community.
Strengthening Collaboration between Workforce, Health, and Human Services to Meet New Federal Requirements
Human Services Policy Advisors Institute | June 24th, 2026 H.R. 1, or “The One Big Beautiful Bill”, introduced significant changes to work requirements across major health and human services programs. including expanding the populations subject to SNAP time limits, reducing state/territory SNAP waiver flexibility, and creating new work requirements in Medicaid. These changes accelerate the […]
Argonne Open House 2026: Science comes to life for visitors
Argonne’s June 27 Open House welcomed more than 8,000 visitors for hands-on science, tours of major research facilities and opportunities to meet researchers across four themes: AI, energy, scientific tools and the universe.
Meet the 2026 NJBIZ Leading Women in Business
NJBIZ names more than 60 Leading Women in Business across industries, plus three Rising Stars, honoring New Jersey professionals.
Meet a PhD student selected for a national Science, Mathematics, and Research for Transformation Scholarship | CWRU Newsroom
Jenna Jaklich is nearly three years away from completing her PhD program in materials science and engineering at Case Western Reserve University, but...
Barcelona and Atletico Madrid meet over Julian Alvarez transfer
Barcelona’s pursuit of Julian Alvarez appears to be moving into a decisive phase, with fresh reports claiming that direct contact has already taken place between the Catalan club and Atletico Madrid...
Reporter: Walker Kessler will meet with Lakers
According to a reporter, the Lakers are one of the teams Walker Kessler will meet with once NBA free agency officially begins.
Ivory Coast vs Norway – Match preview and team news
Ivory Coast and Norway meet in the Round of 32 fixture on Tuesday at the Dallas Stadium after both teams secured second place in their respective group table.Ivory Coast vs Norway – Match preview an...
Rafael Nadal talks tennis prize money, his hotels, and what sports taught him about business
Rafael Nadal opened his fourth Zel hotel as he expands into hospitality, education and sports after retiring from tennis.
How the Chicago Bulls retooled their sponsorship business to meet CMO data demands
As sports sponsorship spending rises, CMOs are looking for hard evidence to justify their deals. Teams and franchise owners are responding, but there’s competition.
FDA panel on peptides will include experts who promote the unproven chemicals favored by RFK Jr.
The Food and Drug Administration is meeting next month to consider easing restrictions on several peptides, a group of unapproved drugs popular with followers of Robert F. Kennedy Jr.
Indy economic development leaders visiting Switzerland on trade trip
The trip will involve meetings with leaders in the life sciences, biotechnology and pharmaceuticals, medical technology, digital heath and advanced manufacturing sectors.
Faculty in Politics, Chemistry, Biology and English Appointed to Endowed Professorships | Pomona College in Claremont, California
Four faculty members have been awarded endowed professorship positions. The Pomona College Board of Trustees voted to support these appointments during their meeting in May.
When sushi meets schools in rural Colorado, everyone wins
NATHAN YIP FOUNDATION Greenwood Village By JOANNE DAVIDSON SPECIAL TO COLORADO POLITICS News: Sushi-lovers from Denver and beyond know that they’re in for a treat when the Nathan Yip Foundation hosts its annual Sushi Party. The rush to purchase tickets begins months in advance and when the big day arrives, the event space atop The Dome at AMG is filled to capacity. […]
LDI and American Healthcare
A news feature from the Pennsylvania Gazette reflects on LDI’s history and leaders, and how they are currently meeting the federal health policy moment.
Local government officials are discussing public business behind closed doors. Is that legal?
Transparency advocates say small group “check-ins” violate the spirit and purposes of North Carolina’s open meetings law.
The Latest: Trump says Iran wants a meeting. Tehran says nothing's scheduled
President Donald Trump says Iran requested a meeting that would happen Tuesday in Qatar, but Tehran says nothing's scheduled.
NEA Nuclear Science Committee advances strategic priorities for the future of nuclear research
The NEA Nuclear Science Committee met on 8-10 June 2026 to advance international collaboration, strengthen scientific expertise, and shape the future of nuclear science through innovation, data and AI.
Meet the worst L.A. free-agent signing ever
There have been a lot of bad free-agent signing in L.A. sports history, but this one rises, or sinks among all the others.
Former ‘Meet the Press’ Executive Producer Betsy Fischer Martin to Lead Harvard IOP | News
Former ‘Meet the Press’ Executive Producer Betsy Fischer Martin to Lead Harvard IOP | News | The Harvard Crimson
Rural Fosston moves forward in its quest to relinquish control of local hospital from Essentia Health
A northwestern Minnesota community is seeking to regain local control of its hospital, arguing Essentia Health has failed to meet local health care needs. A recent court ruling allows Fosston to take its case to arbitration.
Business Owner Questions Buffalo Council on Business Park
At their last regular meeting in June, the Buffalo City Council was asked by business owner Dustin Smith about the status of lots at the Buffalo Business Park, saying he may be interested in purchasing one. He explained further. Smith said he wanted to know what the city was planning for the business park because […]
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Meet the Bruins’ 2026 draft class
Don Sweeney and the Bruins added seven new players to the organization over the weekend in the 2026 NHL Draft.
Alan Ritchson's New Unusually Silent 'Motor City' Movie Described as 'John Wick Meets Reacher'
Alan Ritchson's latest movie is unusual because of its almost complete lack of dialogue.
Leo XIV’s second “business” consistory produced few headlines, but that’s by design
On Saturday, Pope Leo XIV brought an end to the second extraordinary consistory of his pontificate. The meeting of cardinals was not very exciting, which might have been the point.
Punk rock culture meets Portland’s love of soccer and women’s sports in Cherry Bombs FC’s first season
Portland’s new pre-professional women’s soccer team plays the last home game of the short season Sunday at Lents Park.
He’s no longer allergic to the sun, thanks to a clinical trial. Meet Louisiana's ‘vampire guy.’
“I was missing a lot,” Pierre Mouledoux said. “But I'm not missing out anymore.”
Delaware's Most Influential and Inspiring in small business for 2026
Meet eight Delawareans making the list for Delaware Online/The News Journal's Most Influential & Inspiring in small business for 2026.
Standing Committee recommends adoption of four new business items, discusses relationship of the Church of the Brethren and Eder Financial
The Standing Committee of district delegates to the Church of the Brethren Annual Conference held meetings from Thursday evening, June 25, through Saturday afternoon, June 27, in Fort Wayne, Ind. Annual Conference moderator Don Fitzkee presided, assisted by moderator-elect Dennis Beckner and Conference secretary David Shumate.
2026 World Cup: Colombia wins Group K thanks to Portugal draw as DR Congo also advances
We won't get a meeting between Messi and Ronaldo in the quarterfinals.
Soccer meets nature at Vancouver mountaintop watch party
The match between England and Panama was shown on a big screen atop Grouse Mountain, a 4,100-foot mountain that's part of the Pacific Ranges with a sweeping view of British Columbia. When Jude Bellingham scored England's breakthrough goal in the second half, the fans roared. Both Toronto and Vancouver are hosting matches during the tournament.
Fidelio: Classical music meets politics
Vitali Alekseenok is passionate about classical music and politics. He is actively involved in Ukraine, advocates for a free Belarus, and conducts Beethoven's opera of freedom, 'Fidelio,' at the Deutsche Oper am Rhein.
FISU reinforces its commitment to the World University Sports Movement
On the second day of the meeting, the Executive Committee focused on the upcoming Universiades and the future of the FISU Forum. After a first day concentrating on updating statutes and strategies for a simpler, more innovative and effective future, FISU’s Executive Committee focused on upcoming events on this second and last day of their […]
Colorado Politics Calendar June 29-July 5
CoPo’s weekly political calendar will help you find political and public-policy events throughout Colorado. It includes candidate and issue campaign events, public policy meetings, court hearings, state and local party conventions, assemblies, debates, rallies, parades, speaking engagements, traveling dignitary appearances, water meetings, book signings, county commission hearings, city council meetings and more. As a subscriber, […]
Meet a scientist tracking invasive reptiles, and even their parasites
An insider's look at Florida’s war on invaders: the giant snakes, egg-eating predators and parasites spreading through the Everglades.
Meet Troy Rohrbaugh and Doug Petno, who are vying for Jamie Dimon's job
Doug Petno and Troy Rohrbaugh are the frontrunners to succeed Jamie Dimon. Here's a guide to the men in line for one of Wall Street's top jobs.
NY restaurant inspections: Search health code violations by restaurant
Search New York restaurant inspection reports to see if your favorite local dining spots are meeting safety standards.
Democratic candidate challenging Rep. Lawler on her bid to ‘tear down political silos’
New York U.S. House candidate and combat veteran Cait Conley (D) joins Meet the Press NOW following her primary win. She faces incumbent Republican Rep. Mike Lawler in one of November’s most closely watched races as Democrats try to flip the House.
Meet ‘Pepper’ Baumer, The Man With Hot Sauce In His Blood
Hot sauce has been one of the hottest sectors of the food industry and third-generation owner ‘Pepper’ Baumer has built Crystal, his family’s century-old business, into a $50 million Southern staple.
Trustees hear Glencoe neighbors who blast possibility of street parking near business district
Facing opposition from residents living adjacent to the Village’s business district, the Glencoe Village Board has adopted the findings of a long-in-development parking study without three areas that multiple residents spoke against during a recent Village Board meeting. In a 5-0 vote, with Trustee Dudley Onderdonk abstaining, the Glencoe Village Board on Thursday, June 18, […]
Meet Lara Pires, Valedictorian at Community Academy of Science and Health
Meet Lara Pires, Valedictorian at Community Academy of Science and Health
Rock Creek Entertainment District under siege in new lawsuit
A citizens group has sued to block Norman's $1.1 billion Rock Creek Entertainment District, alleging constitutional and Open Meetings Act violations.
Trump Administration Shut Down Climate Website, Former NOAA Employees Have Just Brought It Back
In June 2025, Climate.gov was shut down by an executive order that implied it did not meet the current administration's standards. Climate scientists have just brought the data back.
Meet A Retriever—Manikanta Sirumalla, International Data Science Graduate Student And Entrepreneur - UMBC: University Of Maryland, Baltimore County
If you want help meeting a big new fitness goal, Manikanta Sirumalla may have the app for you. Manikanta came to UMBC from India as a graduate student
Texas Democrats meet for convention amid questions about party unity
Democrats see state Rep. James Talarico, D-Austin, as the best opportunity to flip the long-held Republican U.S. Senate seat and want to see how he will win over Black voters.
Council Explores AI, Quality Improvement and Patient Safety to Advance Community Health
The MHA Council on Health Access and Community Impact held its final meeting of the program year June 4 to examine emerging opportunities and challenges shaping healthcare delivery and advancing community health.
Warren Buffett Bought A Business For $1.7B ‘Over The Phone Without Ever Meeting The People There’ Using The ‘Most Valuable Skill’ He Learned
Buying a company for $1.7 billion without meeting management sounds like the kind of decision that would keep lawyers busy for months. Warren Buffett did it over the phone. Speaking at the University of Nebraska-Lincoln in 2003, Berkshire Hathaway Chair...
Meet the 'Queen of Magazine,' the retail adviser who's brought over dozen brands to the street
We caught up to Carly Ibach during a recent visit to scout out Magazine Street for another national retailer.
Meeting the dozen new inductees in the 2026 Louisiana Sports Hall of Fame class
New inductees for Louisiana Sports Hall of Fame honored at press conference
TravelTech Show, Business Travel Show Europe name 2026 innovation award winners
Arcube, ImpersonAlly, Acai and Nowadays were recognized in separate competitions for travel technology innovations spanning airline retailing, brand protection, contact center automation and meetings management.
Discussing progress in nuclear fuel and materials science
The NEA held the sixth annual week of collaborative meetings of the Working Party on Materials Science Issues in Nuclear Fuels and Structural Materials (WPFM) from 18-22 May 2026 at the NEA offices in Boulogne-Billancourt, France.
City council members request special meeting on planned Sports and Entertainment District
San Antonio Council Districts 1, 5 and 7 want a special meeting before Aug. 7 to guide public input on the Spurs arena’s $75M Community Benefits Agreement as the city considers a $489M Sports and Entertainment District.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Who is Anuk Karunaratne? Meet the Cardinals’ new President of Business Operations
The St. Louis Cardinals formally promoted Anuk Karunaratne to the role of President of Business Operations on Wednesday as the franchise unveiled changes to its organizational leadership structure.
PsychPlus Acquires Koa Health
Houston, Texas-based psychiatry practice PsychPlus has acquired Koa Health, a London-based digital therapeutic and B2B-focused digital mental health
PsychPlus Acquires Koa Health
Houston, Texas-based psychiatry practice PsychPlus has acquired Koa Health, a London-based digital therapeutic and B2B-focused digital mental health
Gov. Jeff Landry appoints two new members to LSU Board of Supervisors. Here’s what to know.
The new supervisors will take their oath of office at Friday’s board meeting.
North Carolina, Illinois basketball to meet at Bridgestone Arena
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Misericordia University Students Earn Top Honors at Pennsylvania Academy of Science's 101st Annual Meeting
Misericordia University students earned multiple prestigious awards while showcasing undergraduate research at the 101st Annual Meeting of the Pennsylvania Academy of Science (PAS), held this year on the Misericordia University campus—the first time the statewide scientific organization has hosted its annual conference at the university.
Mars Meets The Seven Sisters, In Astronomical Event You Won't See Again Until 2034
Mars meets the Pleiades this weekend, the subject of what may be humanity's oldest story.
Another look at carrots and eyesight; how to get more fiber; why mosquitoes bite some people and not others; plus other stories with Vanderbilt Health sources
AARP reporter Stacey Colino interviewed Milam Brantley, MD, Associate Professor of Ophthalmology and Visual Sciences, in 2020 for a story about whether eating carrots can improve vision. Sacramento Bee reporter Samantha Agate has now used Brantley’s comments in an AI-curated story created by content specialists on the same topic that has been picked up by MSN and others. Prevention magazine interviewed Heidi Silver, RD, PhD, Founding Director of the Vanderbilt Diet, Body Composition, and Human Metabolism Core, for a story about the importance of fiber and how people can get more of it in their diet. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Women’s Health (tick bites and alpha-gal syndrome); The Washington Post (tetanus); and Healthline (why mosquitoes prefer to bite some people and leave others alone). A visit to Monroe Carell Jr. Children’s Hospital at Vanderbilt by some Banana Ball baseball players was covered by The Tennessean and WZTV Fox 17 News, and The Tennessean’s story was also picked up by Yahoo! Sports. Clarksville Now published a story written by the Montgomery County Economic Development Team, whointerviewed Bradley Stancombe, MD, professor of Clinical Pediatrics, Vanderbilt Neonatology, about the new energy of Vanderbilt Clarksville Hospital and how the facility is recruiting physicians. Healio Allergy/Asthma group editorial director Richard Gawel interviewed Mark Rolfsen, MD, Clinical Fellow in the Division of Allergy, Pulmonary and Critical Care Medicine, for a story about his presentation at the American Thoracic Society meeting on metal health outcomes following ICU discharge. Nashville Scene reporter Hannah Herner interviewed James Crowe, MD, Director of the Vanderbilt Center for Antibody Therapeutics, for a story about his efforts to prepare for the next pandemic by isolating antibodies that can neutralize dangerous viruses. Medscape reporter Kathleen Doheny interviewed Neesha Choma, Associate Chief of Staff of Vanderbilt University Hospital, for a story about how hospitals can reduce readmissions.