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A night in the life of a scare actor at Dark Harbor in Long Beach
October unleashes a wave of spooky seasonal work for local actors, but all that creeping and crawling isn't easy.
Ex-OpenAI Science Chief Kevin Weil Raises $215M for Drug AI
Former OpenAI science head Kevin Weil launches Warp Sciences with $215 million to use AI and robotics for a critical stage of drug development.
Did a Milwaukee County health insurance contract lapse under David Crowley’s administration?
Yes. Crowley fired a top human resources official after the official admitted to the error.
‘Astronomical’ Arab turnout could reshape Israeli politics in key election
Netanyahu’s opponents consider unprecedented alliances to keep him out of power
Michigan’s new $82M unemployment system launches Nov. 9 after long development process
The new MiUI system will allow unemployed workers to file claims, certify for benefits, view payments and do other tasks through the platform.
Office of Mental Health to relax prior approval process for changing services
The changes will streamline the state’s review and approval process for more than a thousand mental health programs.
Analysis | Saddam’s Cheesecake Factory: Trump’s predecessors go after him in ways only they can
In today’s edition … Voters are changing their minds … You tell me about your first time voting … but first …
SML Center hosts production of Zombie Prom for the spooky season
As the Smith Mountain Lake Center is preparing to create a permanent home at Westlake Cinema, the theater has already become a well-used space for live performances with the newest
Many Medicare Patients Could Lose Access to Remote Monitoring Devices
A proposed federal rule could dramatically reduce access to remote patient monitoring programs for people on Medicare. The services aim to keep patients out of the hospital by giving them devices to monitor their health at home, but critics say there isn’t enough oversight.
Republicans are spending millions and still may not win districts drawn to favor them
Republicans redrew Congressional district lines to try to tilt the midterms in their favor. But now they are facing expensive and competitive races they had hoped to outmaneuver.
Republicans are spending millions and still may not win districts drawn to favor them
Republicans redrew Congressional district lines to try to tilt the midterms in their favor. But now they are facing expensive and competitive races they had hoped to outmaneuver.
Smithsonian scientists launch "Lumina" simulation to model early universe
Researchers introduce "Lumina," a massive cosmological radiation-hydrodynamics simulation designed to model the universe's first two billion years
Bipartisan bankruptcy bill will help struggling small businesses
It’s good for for creditors and landlords, too.
Pa., N.J. and Del. to kick off 2027 ACA health insurance open enrollment on Nov. 1 as health costs rise: What you should know
ACA customers may face higher premium prices for coverage next year, but insurance experts say most people still qualify for financial assistance.
Guest article: Health data is booming. Meaningful insights? Not so much
The growth of wearables means we're awash with data, but not necessarily great insight, says Cornucopian Capital managing partner Aryeh Ganz.
Better targeted actions needed to tackle unequal impacts of noise pollution for vulnerable groups
Noise pollution affects us all, but some populations like children, older adults and people with pre-existing health conditions may suffer more health wise due to excessive transport noise according to a European Environment Agency (EEA) briefing released today. The analysis recommends better targeted actions to protect vulnerable and disproportionately exposed populations.
Business News: Audemars Piguet Unveils 'The Watch Keepers' - A Digital Platform Offering Certified Pre-Owned Watches
The Le Brassus watchmaker will facilitate sales and auctions of brand-certified timepieces on a digital platform launching in Switzerland and Europe, with plans for expansion to other markets, including the U.S.
‘Been a Problem for a Very, Very Long Time’ — Revisiting the Time Fox’s Pam Oliver Revealed the Health Battle That Impacts Her Sideline Reporting
NFL sideline reporter Pam Oliver has been a fixture in the business for more than 30 years, covering the league for Fox. At 65, she’s also one of the most experienced voices on the sidelines, most recently covering the San Francisco 49ers’ Week 7 matchup against the Atlanta Falcons.
Cole Caufield’s Canadiens claim will surely divide fans across Canada
The Montreal Canadiens are having a fine start to the 2026-27 NHL season. Cole Caufield and his teammates are looking to return to the Stanley Cup Playoffs. In outdoor conditions on Sunday, Caufield was a big star for the Habs against the Winnipeg Jets. The Canadiens defeated the Jets 2-1 in the Heritage Classic at Princess Auto Stadium in […] The post Cole Caufield’s Canadiens claim will surely divide fans across Canada appeared first on ClutchPoints.
Fabarta Unveils Major Upgrade to Its AI for Science Platform, Named Among Inaugural "Hong Kong Top Talent Ecosystem Partners" Ahead of Hong Kong FinTech Week
PR Newswire | Powered by the upgraded RSI engine, the platform unifi
2026 FLIBS Nightlife Strategy: High-Powered Networking to Uninhibited After-Hours Entertainment in Fort
OutboardListings.com explores corporate networking, waterfront social experiences and Fort Lauderdale nightlife during FLIBS 2026.
SpaceX secures $40B in financing for GPUs as Elon Musk warns of AI cloud industry consolidation
SpaceX closed $40 billion in debt financing for GPU purchases as Elon Musk warns AI debt markets have shut off access for most companies.
14-year-old Ngozi Wright makes feature film début
At just 14 years old, Ngozi Muzik Wright adds another milestone to an impressive performing arts journey that began when she was barely old enough to speak. The gifted young Jamaican, whose commanding dub poetry performances have captivated audiences at home and throughout the diaspora, has stepped on to the big screen in her first full-length feature film, From A Yardie To A Yankee.
How to Manage Symptoms of Heart Failure
(Feature Impact) Americans are facing a growing health challenge, with 1 in 4 adults at risk of heart failure, according to the Heart Failure Society of America. Additionally, approximately 6.7 million U.S. adults who are 20 years old or older are currently living with heart failure, and that number is projected to reach 8.7 million by 2030. googletag.cmd.push(function() { googletag.display('JGFI_Article_300x250'); }); Managing heart failure is a significant expense to the U.S. healthcare system, costing the nation approximately $40 billion in 2020 and expected to increase to approximately $142 billion a year by 2050.If you (or a loved one) are living with the condition, consider these tips to help manage it.Adhere to the Treatment and Follow-Up PlanOngoing outpatient care is important when managing heart failure. Understand the treatment plan provided by your healthcare team, make diet and lifestyle changes, take medications as directed and keep recommended follow-up appointments.Pay attention to changes in symptoms and communicate with your healthcare provider if treatment does not seem to be working as expected. If their conditions are left unmanaged, patients can experience a range of heart-failure-related symptoms such as shortness of breath, fatigue, buildup of fluid and more.Understand Challenges with Diuretic TreatmentDiuretics help the body remove excess fluid and are commonly used to treat swelling, or edema, associated with heart failure. Your provider may try different diuretics, sometimes referred to as “water pills,” to manage your heart failure symptoms. However, intravenous (IV) diuretic therapy may be required for some patients if symptoms continue.Ask About Treatment Options Before IV Care Is NeededFor some adults, a healthcare provider may consider recommending an at-home, non-oral diuretic option prior to escalating to IV therapy.For example, ENBUMYST™ (bumetanide nasal spray) is a prescription diuretic used in adults to treat edema associated with congestive heart failure. It’s administered as a nasal spray for short-term use to manage excess fluid with the goal of transitioning to oral diuretic therapy when appropriate.Talk with your healthcare provider to learn more and visit enbumyst.com. Read the full Prescribing Information and Patient Information.Photo courtesy of Shutterstock googletag.cmd.push(function() { googletag.display('JGFI_Article2_300x250'); }); Important Safety InformationWhat is ENBUMYST?ENBUMYST is a prescription medicine used in adults to treat swelling caused by excess fluid in the body (edema) from congestive heart failure, liver disease, and kidney disease.What is the most important information I should know about ENBUMYST?ENBUMYST is a diuretic that helps your body remove fluid. Losing too much fluid can cause dehydration, low blood volume, and increase the risk of blood clots. Blood abnormalities may include decreased salts (electrolytes), and increased nitrogen, glucose and uric acid. The risk of these abnormalities is higher in elderly people, those using higher doses, or those who do not get enough electrolytes by mouth.You should not use ENBUMYST if you have severe electrolyte loss. Tell your healthcare provider if you experience unusual thirst; dizziness or lightheadedness; weakness or tiredness; fast heart rate; dry mouth or tongue; sudden pain; redness or swelling in your joints; pain, swelling, redness, or warmth in your leg; shortness of breath or fast breathing; high blood sugar; dark urine; pale, tight, cool or clammy skin; muscle cramps; confusion.Do not use ENBUMYST if you have low or no urine production or are allergic to bumetanide or to any of the ingredients in ENBUMYST.Before using ENBUMYST, tell your healthcare provider if you have low electrolytes, are on a low-salt diet, have diarrhea, diabetes, nasal problems such as a runny or stuffy nose or polyps, a history of nasal injury or surgery, are or plan to become pregnant, are or plan to breastfeed.Tell your healthcare provider about all the medicines you take, including prescriptions, over-the-counter medicines, vitamins, and herbal supplements.ENBUMYST may cause serious side effects, such as worsening kidney function and ringing in the ears or hearing loss.The most common side effects of ENBUMYST include dehydration, headache, muscle cramps, dizziness, low blood pressure, nausea, and abnormal brain functioning with certain liver problems.These are not all the possible side effects of ENBUMYST. Talk to your healthcare provider for more information.Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.US-ENBU-2600110 googletag.cmd.push(function() { googletag.display('JGFI_Article3_300x250'); });
E-Z Health helps seniors find relief with dedicated healthcare phone guides
Closing the technology gap, a Medicare-covered program is helping seniors find local resources and save money on essential services. FOX 10's Annalisa Pardo reports.
West Virginia Senate District 2 race pits political newcomers Heaney, Claypole
With West Virginia Sen. Charlie Clements deciding not to run again in this year’s election, two political newcomers are vying to take over the seat representing
China's Rise in Science as a Source of Strategic Power
China is on course to lead the world in research and development, a shift with direct consequences for technological competition and the balance of global power. That is the conclusion of a news feature by Xiaoying You in Nature, published on October 14, 2026. The scale of the change is striking. In 1978, researchers in […]
US has plans for major Iran strikes if Trump chooses
US forces in the Middle East are prepared to launch new, potentially major, military operations against Iran “within 96 hours of receiving” an order from President Donald Trump, according to two US officials.
Graphic Medicine: How Comics Are Transforming Healthcare
Graphic medicine pioneer Ian Williams highlights how comics can communicate medical experiences, build empathy, and offer perspectives beyond textbooks.
Who are the scariest Arizona Diamondbacks players in history?
PHOENIX — With Halloween around the corner, some of the Arizona Diamondbacks’ scariest figures aren’t in haunted houses, but on the diamond. Throughout their history, several players have struck fear into opponents through overpowering performances, intimidating appearances and unforgettable moments.
Community members speak out during tense mental health advisory board meeting
Community members impacted by the withdrawal of Kings View services shared concerns during a mental health advisory board meeting last week, saying the closure of a local mental health center had left gaps in care. Board members also navigated a number of other tense moments during the meeting.
How Do the Blazers Stop Luka Doncic?
Fresh off a 2-0 start, Portland faces a 52-point fireball in Los Angeles. To survive, the Blazers must stifle the high pick-and-roll while shielding their smaller guards.
How to talk politics with family: Minnesota debate coach shares tips
A University of Minnesota debate coach is sharing advice on navigating political disagreements ahead of Election Day. He explains winning the argument isn't necessarily the goal of a political debate.
How to talk politics with family: Minnesota debate coach shares tips
A University of Minnesota debate coach is sharing advice on navigating political disagreements ahead of Election Day. He explains winning the argument isn't necessarily the goal of a political debate.
Reimagining the future: Global experts gather in Beijing to rethink science museums in the age of AI
In today's AI era, where knowledge is easily accessible, the significance of science museums lie in invoking emotions, creating memorable experiences, and providing a space for reflection and meaningful dialogue, experts suggest.
Adventist Health provides hundreds of people with free health and food services
Adventist Health held its second annual free health clinic at the Templeton Hills Seventh-day Adventist Church.
Shares fall in Asia after a decline on Wall Street, and oil prices fall more than 1%
Shares are mostly lower in Asia after a retreat on Wall Street, while oil prices have fallen more than 1%.
'Serious allegations': Gov. Spanberger addresses Sen. Lucas charges for marijuana business
Nu Holdings (NU) Faces Political And Leadership Questions, Does It Look Fairly Valued?
Election shock and leadership change put Nu Holdings in focus Nu Holdings (NYSE:NU) is under fresh scrutiny after a Brazilian election result sparked a double digit overnight drop in the stock, just as the fintech disclosed a pending chief technology officer departure. Over the past month, Nu Holdings has seen an 11.55% share price return and a 4.12% gain over seven days, even though the year to date share price return is down 10.93% and the one year total shareholder return has declined...
Khaman Maluach Isn't Running From Massive Expectations With Suns
The current center situation in Phoenix raises the level of pressure that Maluach faces. He uses the outside noise as fuel to tangibly improve.
Stray gunfire hits business after early-morning shooting in the Tower District
A business in the Tower District was hit by stray gunfire on Sunday.Fresno Police officers responded to a reported shooting in the area of Fulton and Dennett a
Georgia lands son of music star in notable recruitment win
Georgia football secured a notable win during its bye week Sunday. And in the process, coach Kirby Smart and company win over fans of country star Luke Bryan. That’s because his son Bo Bryan is joining the 2027 recruiting class. The three-star quarterback chose the Bulldogs officially, becoming the newest College Football Recruiting win for […] The post Georgia lands son of music star in notable recruitment win appeared first on ClutchPoints.
🚨 Line-ups confirmed for América
América hosts Pachuca tonight at Estadio Banorte on Matchday 14 of the Apertura 2026, looking to secure top spot, while Tuzos will go all out to reach the playoffs despite their slim chances.América...
Arizona business opens doors for employees with criminal records
An Arizona-based luxury door manufacturer is prioritizing hiring formerly incarcerated individuals to help them successfully re-enter society.
Politics Unplugged (Full Episode) Oct. 25, 2026
On this week's episode of Politics Unplugged, host Dennis Welch and a panel break down Arizona's election landscape one week out: pessimistic voter mood, suppressed independent turnout, lagging GOP enthusiasm, and Democrats gaining ground. They discuss Elon Musk's late spending in competitive House races and debate the impact of big money flooding the state. The show also covers a widely condemned Ohio attack ad by Vivek Ramaswamy that weaponizes a rival's childhood abuse—drawing praise from Trump and Vance but bipartisan outrage.
He's competed in 21 Hyrox races around the world: 3 top host cities
Lau Wen Loong has been competing in Hyrox races for two years and feels super fit. "I never imagined I could be faster than my younger self."
Fresno police investigate shooting at Airbnb rental in Tower District
The Fresno Police Department is investigating a shooting that occurred early Sunday morning in a Tower District neighborhood.
Johnson County Focus on Youth Fund promotes access to children’s mental health resources
This is an installment of a series exploring youth mental health. The Daily Iowan has received a grant and is partnering with the Solutions Journalism Network to explore the topic. The Johnson County Focus on Youth Fund has been promoting access to children’s mental health resources by providing funding for families who can’t afford services....
Claude AI accessed publicly available Georgia voter data, Anthropic confirms
Officials said the AI bot accessed publicly available voter data through the state's data hub but did not access voter files or Georgia's voter registration system.
Tiny magnetic vortices could help computers work more like your brain
Scientists have filmed tiny magnetic vortices called skyrmions melting out of an organized lattice for the first time, revealing new ways to manipulate these unusual structures. The breakthrough could help make brain-like computers a reality, potentially enabling dramatically smaller and more energy-efficient technology.
Innovative food processing technique boosts Nebraska companies, educational outreach
Leadership and strategic visioning by Mary-Grace Danao, research associate professor in the Department of Food Science and Technology and the Department of Biological Systems Engineering, has helped position the University of Nebraska–Lincoln at the forefront of high pressure processing-focused food safety research in partnership with private industry.
UCLA Library's Data Science Center closed amid consolidation effort
UCLA Library dissolved its data consultation center and stopped offering data analysis services in August. The university consolidated the Data Science Center into UCLA Library’s research services unit as part of a broader effort to restructure the department, a UCLA Library spokesperson said in an emailed statement.
Gauging Global Access to Dermatology Care: Q&A With Esther E. Freeman, MD
Dermatologist and epidemiologist Esther E. Freeman discusses the Global Access to Skin Health Observatory Study and how its findings will hopefully help improve dermatology care worldwide.
Business is booming for Giacinta’s at the Bridge
BRIDGEPORT – Since welcoming Giacinta’s Gelato & Caffe to their new location in the multipurpose Bridge at Bridgeport Exempted Village School District, the place has been a go-to spot for students and community members looking for that morning pick-me-up. Owner Audrey Brahler made some time between morning rushes of buyers to talk about the success […]
Autism study reveals neural circuit supporting flexible learning
Researchers have identified a brain circuit linked to the flexible formation of memories that may help explain some of the differences in learning associated with autism spectrum disorder.
Phantom Blade Zero review: dark wuxia martial arts masters with an apprentice's execution
S-Game's Unreal Engine 5 'kungfupunk' debut can't help but get tangled in frustrating design choices.
Med Center Health Heroes Fest a huge success
Email newsletter signup Polls What is the biggest challenge facing Bowling Green? Vote Now View Results
Elon Musk’s Grok Imagine Releases First Odyssey Episode With Wonder Studios
8 sources compared: Other (4), Western Mainstream (3), Latin American (1). Elon Musk’s Grok Imagine released the first episode of its AI-generated series “The Odyssey,” posting a seven-minute vid...
Kyle Larson’s Championship Moment Comes at Talladega
Conquering his drafting-track demons, Larson surged from mid-pack chaos to secure a historic Hendrick 1-2 finish, building a massive points cushion that places the title within reach
Chiefs vs. Seahawks live updates, inactives, where to watch: Kenneth Walker III faces Seattle for first time since Super Bowl MVP run
Kids celebrate with big Halloween fun at University Health's Fall Fest!
Hundreds of children who were born prematurely or with special needs reunited Thursday night for University Health’s annual Halloween Fall Fest, turning a night that was only open to families into a celebration of
Judges skeptical of Trump administration effort for force California to set aside mail ballots
A three-judge US Circuit Court of Appeals panel expressed significant skepticism Sunday over the Justice Department’s desire to inject itself into California’s midterm vote-counting process by forcing election officials to set aside the votes of suspected noncitizens who have been issued mail ballots.
Veteran Makers Market highlights importance of supporting veteran-owned businesses
The Veteran Makers Market spotlights veteran-owned businesses, encouraging shoppers to support those turning military skills into local success.
Molina Healthcare awards $15,000 grant to expand tribal cultural wellness initiative
Over 300 students learn science and technology at CCSD Family STEM Day
Over 300 students learned about science and technology industries at the Clark County School District Magnet Schools Family STEM Day on Saturday.STEM Day as he
Martin Short's Says His Countdown for Showbiz Sucess Was a Year With Social Work as Plan B
Cooper Health launches new mobile addiction and recovery program
The program will focus on high-need areas in the city and respond elsewhere when called, helping to connect people to addiction support services. | KYW Newsradio
Health West Chubbuck expands hours, adds X-ray services and two new providers
CHUBBUCK — Health West has announced that it has expanded the services offered at Health West Chubbuck and that it has added two new providers to its staff as well
Everton’s five-game winning home run ended by Aston Villa
Everton’s five-match winning run at Goodison Park has come to an end with Aston Villa running out 3-2 winners on Merseyside this afternoon.Brian Sørensen enjoyed a successful return to his former c...
Is an Academy of Natural Sciences divorce coming?
Hearings for the museum are coming Monday. Will it make a difference?
Cleveland Browns rookie WR hits historic mark against Titans
KC Concepcion’s 129 receiving yards places him in the Top 10 for a single game by a rookie in franchise history.
6 Essential Gadgets For Learning To Play Guitar
We've picked out some of the best gadgets to support the process of learning to play the guitar, including for timing, ear training, and song practice.
Germaphobe primates want to avoid getting sick, too
Some monkeys become significantly more cautious about food sources that appear contaminated after experiencing deadly outbreaks of disease.
Merit Health announces Trunk or Treat for Thursday
merit: Join the fun at Merit Health River Region's annual Trunk or Treat on October 29. Dress up and enjoy festive activities!
‘Masterplan’: Too lightweight to make an impact
Pretty faces can’t overcome ho-hum plotting
Dodgers’ De Paula Faces Key Defensive Test
Josue De Paula impressed the Los Angeles Dodgers with his bat during his major-league debut. Can he do the same with his defense?
Asher Grunis steps down from leading Submarine Affair commission due to health concerns
Supreme Court President Isaac Amit appointed retired Supreme Court justice Zvi Zylbertal to replace Grunis and lead the commission on Sunday.
Santa Ynez Tribal Health Clinic to Salute Veterans with Free Dental Services at Annual 'Veterans Smile Day' Event
Credit: Courtesy SANTA YNEZ, CA – October 21, 2026 – The Santa Ynez Tribal Health Clinic (SYTHC) will salute veterans with free dental services at its
Nets' Second-Year G Dëmin Bounces Back Against Cavaliers
The Brooklyn Nets got a much-better performance from second-year BYU product Egor Dëmin against the Cleveland Cavaliers. With Mikel Brown Jr. on a minutes restriction, Dëmin needs to play a big role.
Trump on high gas prices: 'We're making a freaking fortune"
Americans, meanwhile, are paying record prices at the pump, according to AAA.
Scientists Discover How Excess RNA Can Disrupt the Energy Supply Inside Cells
Scientists at Texas A&M University discovered that excess RNA can interfere with the machinery cells use to produce energy, even without triggering certain immune defenses. The findings reveal an unex...
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s...
'You Can See Everything' Surges With $19.5M at Box Office; 'Clayface' Takes No. 1
NEW YORK (AP) — DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s Elizabeth Holmes documentary “You Can See Everything,” which pulled in $19.5 million in its ...
Senate rivals seek support from Alaska Native voters
The major candidates in Alaska’s U.S. Senate race are both casting themselves as strong voices on Alaska Native issues as they seek support from the key constituency ahead of the Nov. 3 election
The Making Of: Addams Family Values, Ocean Software's Attempt to Mix Hollywood & the Legend of Zelda
"Management didn't really understand development or the creative process"
This Switch 2 sequel accessory was a few millimeters away from being good
The right stick gets in the way.
Lakers 1st-Round Draft Pick Floated as Trade Piece
The Los Angeles Lakers are off to a fast start. Could it be time to weigh trading away some young pieces to boost the rotation? The post Lakers 1st-Round Draft Pick Floated as Trade Piece appeared first on HEAVY.
'Not a one-person job:' Bernardsville explores exit from Bernards Health Department
BERNARDSVILLE - Concerns about costs have led borough officials to consider cutting off decades-long services from the Bernards Township Health Department and switching to the Somerset County Health Department.
MTSU named among Billboard's Top Music Business Schools for 12th year in a row
Middle Tennessee State University has been named a top music business school by Billboard for the 12th year in a row.MTSU's Department of Recording Industry mad
3 comments | Progressive Democrats are closely watching four Senate...
Progressive Democrats are closely watching four Senate races in the upcoming midterm elections. Our politics reporter Kellen Browning explains why.
Connections: Law firms hire attorneys for NWA offices
Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...
Connections: Law firms hire attorneys for NWA offices
Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Timeline of the Capitol Annex project
Ashley Zavala looked back at the decade-long process of building the new offices for the governor and state lawmakers.
Apple Stores Reportedly Rolling Out New Anti-Theft System for iPhones
Bloomberg's Mark Gurman today reported that Apple is facing a growing problem where some people will buy iPhones or other products and either remove accessories from the box, open up the device and remove components, and/or remove the entire device, and then attempt to return the box hoping that the employee will not notice.
Wrexham’s Summer Striker Decision Faces Fresh Scrutiny After Blackburn Defeat
Wrexham’s decision to back their current centre-forwards has become a renewed talking point after Saturday’s 2–0 defeat at Blackburn Rovers exposed the gap between attacking activity and a meaningful goal threat.
MCHD: Several people treated at local emergency rooms for bat bites in Baldwin County
The Mobile County Health Department says the patients were bitten at different residences in Baldwin County.