SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " bar " 7,117 found 🔀 AI-powered Shuffle
An Unknown Trick to Identifying High-Probability Fantasy DST Bargains
Is there a new way to identify a high-probability fantasy DST bargain? Yes there is, and here's how.
Mid-Coast Energy Systems Celebrates 50 Years of Business
Many drivers on Route 1 in Damariscotta recognize the large white renovated barn as they drive toward Wiscasset. The building is home to Mid-Coast Energy Systems, which is celebrating its 50th anniversary this year.
How geopolitical rifts cut scientific collaboration
Researchers have measured how worsening geopolitical relations hobble scientific collaboration, at last quantifying the impact of rifts between governments on cooperation between labs. Over the last decade, a tenser world has thrown up new barriers to cross-border science. Collaboration between the US and China has dimmed as the two countries have sunk into an ever-deeper rivalry. Links between Russia and Europe have collapsed following Moscow’s full-scale invasion of Ukraine. But while a concern, the magnitude of the damage is less than might be expected. For all the geopolitical turmoil of the last decade, international scientific collaborations are near a record high. “Some part of the story is positive,” said Shreyas Gadgin Matha, a social scientist at Harvard University and an author of the new study. “Research collaborations are largely resilient.” Matha and colleagues looked at data on cross-border research papers and patents in the period 2000-23, and analysed how they were impacted by countries’ political relations, as measured by how often states voted together in the United Nations. They found that when states drift apart at the UN by the median difference in votes between all countries, joint scientific papers decline by 3.1% over the next three-year period. To put that in context, over the last decade, the US and China have diverged by around a third of that difference in votes every three years. In other words, on average, it takes quite a significant diplomatic rift even to trigger a small single-digit percentage drop in joint papers. “In the short term, even something like a 3% reduction [in joint papers] is, in some ways, not that big of a number,” said Matha. Research remains more international than ever, according to an analysis extending to 2023 released by the Organisation for Economic Cooperation and Development (OECD) in 2025. We’re still living in an era of unprecedented scientific globalisation, the analysis says, with 27% of papers in OECD countries written across borders. In 1970, just 2% of articles had authors from different countries. Longer-term damage?However, this trend towards increasing international collaboration “has lost momentum and might be partly breaking down,” the OECD analysis says, largely due to a fall in the intensity of US-China joint papers since 2018. Matha and his colleagues stressed they are not complacent about the global science system. For now, “it's pretty resilient,” said co-author Muhammed Yildirim, director of academic research at Harvard’s Growth Lab. But if links are weakened, through the denial of study visas, for example, then this could have a much longer-term effect, cascading through generations of scientists, he added. Related articlesChina becomes Russia’s biggest collaborator after war decimates science ties with the west US scientists prefer German to Chinese collaborators, study finds Horizon Europe is now truly global. But what comes next? Another finding of the study, Burning bridges or bridging divides: Geopolitics and collaboration in research and innovation, is that trust appears easier to destroy than create.The hit to scientific collaboration when countries drift apart is around three times as big as the growth in joint papers when they move closer, the paper finds. “It's far easier to break these ties than to mend them, and that that also perhaps has some larger policy lesson,” said Matha.PatentsThe results around patents were less clear cut. Some methods of analysis found a statistically significant link between a diplomatic rift and a drop in co-patenting, but others did not. According to Yildirim, patents with cross-border inventors are often developed by multinational companies, which may have invested heavily in global R&D facilities, so are less likely to change how they operate simply due to a change in the geopolitical weather. “That's why we might not be seeing the effect immediately in technology,” he said.By contrast, researchers might be more sensitive to geopolitics, because visa policies can quickly affect who meets who at academic conferences, he went on. International collaboration on patents is much lower than for academic articles, the study shows. It peaked at around 10% in 2010, and has since fallen back to around 8%. This could be because China dramatically ramped up domestic patents in the 2010s, said Yildirim, squeezing the international share.
How geopolitical rifts cut scientific collaboration
Researchers have measured how worsening geopolitical relations hobble scientific collaboration, at last quantifying the impact of rifts between governments on cooperation between labs. Over the last decade, a tenser world has thrown up new barriers to cross-border science. Collaboration between the US and China has dimmed as the two countries have sunk into an ever-deeper rivalry. Links between Russia and Europe have collapsed following Moscow’s full-scale invasion of Ukraine. But while a concern, the magnitude of the damage is less than might be expected. For all the geopolitical turmoil of the last decade, international scientific collaborations are near a record high. “Some part of the story is positive,” said Shreyas Gadgin Matha, a social scientist at Harvard University and an author of the new study. “Research collaborations are largely resilient.” Matha and colleagues looked at data on cross-border research papers and patents in the period 2000-23, and analysed how they were impacted by countries’ political relations, as measured by how often states voted together in the United Nations. They found that when states drift apart at the UN by the median difference in votes between all countries, joint scientific papers decline by 3.1% over the next three-year period. To put that in context, over the last decade, the US and China have diverged by around a third of that difference in votes every three years. In other words, on average, it takes quite a significant diplomatic rift even to trigger a small single-digit percentage drop in joint papers. “In the short term, even something like a 3% reduction [in joint papers] is, in some ways, not that big of a number,” said Matha. Research remains more international than ever, according to an analysis extending to 2023 released by the Organisation for Economic Cooperation and Development (OECD) in 2025. We’re still living in an era of unprecedented scientific globalisation, the analysis says, with 27% of papers in OECD countries written across borders. In 1970, just 2% of articles had authors from different countries. Longer-term damage?However, this trend towards increasing international collaboration “has lost momentum and might be partly breaking down,” the OECD analysis says, largely due to a fall in the intensity of US-China joint papers since 2018. Matha and his colleagues stressed they are not complacent about the global science system. For now, “it's pretty resilient,” said co-author Muhammed Yildirim, director of academic research at Harvard’s Growth Lab. But if links are weakened, through the denial of study visas, for example, then this could have a much longer-term effect, cascading through generations of scientists, he added. Related articlesChina becomes Russia’s biggest collaborator after war decimates science ties with the west US scientists prefer German to Chinese collaborators, study finds Horizon Europe is now truly global. But what comes next? Another finding of the study, Burning bridges or bridging divides: Geopolitics and collaboration in research and innovation, is that trust appears easier to destroy than create.The hit to scientific collaboration when countries drift apart is around three times as big as the growth in joint papers when they move closer, the paper finds. “It's far easier to break these ties than to mend them, and that that also perhaps has some larger policy lesson,” said Matha.PatentsThe results around patents were less clear cut. Some methods of analysis found a statistically significant link between a diplomatic rift and a drop in co-patenting, but others did not. According to Yildirim, patents with cross-border inventors are often developed by multinational companies, which may have invested heavily in global R&D facilities, so are less likely to change how they operate simply due to a change in the geopolitical weather. “That's why we might not be seeing the effect immediately in technology,” he said.By contrast, researchers might be more sensitive to geopolitics, because visa policies can quickly affect who meets who at academic conferences, he went on. International collaboration on patents is much lower than for academic articles, the study shows. It peaked at around 10% in 2010, and has since fallen back to around 8%. This could be because China dramatically ramped up domestic patents in the 2010s, said Yildirim, squeezing the international share.
Como 1907: The Italian Club That Barely Feels Italian Anymore
When Como 1907 walk out for their first-ever Champions League match against RB Leipzig on Thursday, they’ll do so as a club that has rewritten its identity almost completely. Founded in 1907 on the shores of one of Italy’s most famous lakes, the team now fields a squad so international that many Italians complain it […] The post Como 1907: The Italian Club That Barely Feels Italian Anymore appeared first on HEAVY.
Talarico unveils GOP support, including former Dallas elected leaders
A group of Republicans supporting James Talarico includes former Dallas Mayor Steve Bartlett, former U.S. Rep. Alan Steelman and former Tarrant County Judge Glen Whitley.
California judge suspends license for salvage inspection business
A California judge has suspended the license of a Los Angeles-based automotive dealer after a Bureau of Automotive Repair (BAR) investigation found the business performed fraudulent vehicle safety …
Farke explains why defender was forced off against Chelsea
Daniel Farke defended his decision to rotate his Leeds side after they surrendered a two-goal lead in a 6-3 Carabao Cup defeat to Chelsea – and eased injury worries over defender Melvin Bard.Leeds l...
Oil Above $100 Puts US Politics and Saudi Security Under Pressure
Oil prices climbed back above $100 a barrel […]
Is San Antonio's gut health boom backed by science or hype?
From kefir bars to a lupus breakthrough, San Antonio is having a gut health moment. Scientists explain what's evidence-based and what's not.
Is San Antonio's gut health boom backed by science or hype?
From kefir bars to a lupus breakthrough, San Antonio is having a gut health moment. Scientists explain what's evidence-based and what's not.
First win a 'release' as re-build continues
Manager Adam Murray says Barrow felt a "release of frustration" rather than celebration after their first win of the National League season.
‘Bigger than any team’: Legendary hockey broadcaster Barry Melrose dies at 70
Barry Melrose, a hockey player-turned-coach who led the Los Angeles Kings to the 1993 Stanley Cup Final before going on to a long career in broadcasting the sport, has died
Want to buy an iconic piece of Wichita? This bar with 1935 roots is for sale.
Sabrina Parker, the longtime owner of Merle’s Place at 440 N. Seneca, wants to sell the business and its 1935 building.
Barça coach Flick: Yamal deserves the Ballon d'Or
Barcelona coach Hansi Flick believes his star winger Lamine Yamal is the clear favourite to win the Ballon d'Or as the planet's best male footballer. The ceremony is on October 26 in London where the Spain World Cup winner will be up against the likes of Harry Kane, Lionel Messi, Rodri and Kylian Mbappé.
Barca's Rodri apologises over Valencia 'weak' comments
Barcelona midfielder Rodri says he has apologised to the entire Valencia squad after television cameras appeared to catch him describing the La Liga strugglers as "very weak".
‘Horrible Game From Drake (Maye), Disgusting’ — Barstool Sports’ Dave Portnoy Rips Patriots QB After Meek Week 1 Loss to Seahawks
The New England Patriots opened the season with a result that has quickly turned optimism into frustration. A promising 10-0 start against the Seattle Seahawks on Wednesday night disappeared as the Patriots struggled to finish drives and protect their lead against a team that lost its quarterback on the opening drive.
To protect science in the AI era, train researchers better
Universities must guide on how distrust is manufactured and how misconduct operates, says Baraa Khuder
Cosm aims to dazzle Detroit sports fans with tech and comfort
The main attraction in downtown Detroit's Cadillac Square is an 87-foot-diameter LED Dome with plush seating, a gametime menu and multiple bars.
Sydney Sweeney strips down for provocative new ad campaign
The “Euphoria” actress bares it all to promote Novig, a sports prediction market.
Is Six Flags Entertainment (FUN) A Bargain On Its New Flex Pay Launch?
Six Flags Entertainment (FUN) just rolled out Flex Pay by Upgrade, a buy now pay later style option for online purchases from $49, including Season Passes and other qualifying products. For investors watching Six Flags Entertainment, the latest product moves are coming against a tougher backdrop, with the share price down 41.4% over the past 90 days and the 1 year total shareholder return declining 34.0%. This points to fading momentum and a market that is pricing in higher risk, even as...
Legendary ESPN hockey analyst Barry Melrose passes away at 70
The hockey world has been dealt a tragic blow as iconic ESPN hockey analyst Barry Melrose has passed away. ESPN made the announcement on Wednesday evening. Melrose spent a lifetime in hockey as a player, coach, and television analyst. He played over 300 games in the NHL as a defenseman in the 1970s and 1980s.…
Florida Coach Disappointed With Defensive Performance in Week 1
Despite a blowout victory, Florida HC Jon Sumrall blasted his unit’s low football IQ and lack of pace, warning of total embarrassment unless the Gators sharpen their defensive standards.
New Orleans’ French Quarter gets its first-ever marijuana dispensary. ‘I’m speechless.’
A cannabis dispensary opens on Bourbon Street, marking the first medical dispensary in the French Quarter. NOLA Cannabis Co. offers free telehealth consultations with a fast turnaround, a flower bar, cannabis education and more.
New AI health tools need ‘L-plates’, says UK review
Proposals following national consultation on health tech regulation call for live monitoring as AI moves deeper into patient care
Andoni Iraola dismisses injury worries over Bradley Barcola
Barcola went off against Atletico on the hour holding his left calf.
Chelsea 6-3 Leeds: Morgan Rogers-inspired Blues net SIX second-half goals in breathless comeback win
Report and free match highlights from the Carabao Cup third round tie between Chelsea and Leeds at Stamford Bridge; Blues net six second-half goals with Cole Palmer, Danny Welbeck, Pedro Neto and Valentin Barco on target
MedStar Health Offers New Nonsurgical Weight-Loss Procedure
/PRNewswire/ -- For the first time at MedStar Health, patients struggling with obesity who may not want, or may not qualify for traditional bariatric surgery,...
Bill Barnwell Picks Lions to Go Worst to First
Bill Barnwell picks the Lions to win the NFC North and the Vikings to miss the playoffs. #Lions
I flew business class on a budget flight—and it was better than some legacy airlines
A firsthand look at JetBlue's new Boston-to-Barcelona flight, from lie-flat seats to food, service, and what's actually worth it.
Barcelona star issues public apology to Valencia
Barcelona star Rodri has on Wednesday sent a public apology message the way of all associated with La Liga rivals Valencia.This of course comes after the summer arrival in Catalunya’s capital sparke...
Blizzard Entertainment Workers Ratify First Contracts
The deals require management to bargain over the use of AI in the workplace and enshrine layoff protections at the Microsoft-owned company.
Santa Barbara Chamber Players Opens With Shostakovich, Mozart
Cellist Jakub Omsky will be a soloist at Santa Barbara Chamber Players concert. (Bob Houchens photo) The Santa Barbara Chamber Players will open its 2026
Arrest made after quadruple shooting at sports bar
Memphis police arrested a man accused in a shooting at a sports bar last month.
📸 Barcola's unbelievable miss 😱
Old demons.This Wednesday evening, Liverpool begin their 2026-2027 Champions League campaign with a heavyweight clash against Atlético de Madrid. Making his very first start since his huge summer tra...
Kathy Griffin jokes Barron Trump sends her notes pleading, ‘Don’t kill my daddy’
Kathy Griffin looks back on her Donald Trump photo scandal, joking to EW that Barron Trump sends her notes saying, ‘Don’t kill my daddy.’
UF Health Jacksonville mobile health unit targets barriers to healthcare
UF Health Jacksonville expects its mobile health unit will provide blood pressure, cholesterol and diabetes screenings and preventative services.
60 Posts in 10 Hours: How Trump’s Social Media Reflects His Version of Reality
With an assist from A.I., President Trump offers a window into how he wants to be seen — and, critics say, a barometer of his mental state.
Boston Dynamics spinoff looks to build robots for entertainment
Dynamic Creatures is building theme park robots on Chinese hardware. Europe's own social robotics champion was sold to a Shenzhen buyer last year.
💎 Lamine Yamal, Champions League's third-youngest free-kick scorer
Lamine Yamal makes it 4-0 for Barcelona against Feyenoord with his first direct free-kick goal in the Champions League. The stat is confirmed by MisterChip: at 19 years and 58 days old, the winger bec...
🤝 Van Persie heritage continues in the Champions League
Despite Feyenoord's struggles in Barcelona this evening, one special moment added a shine to the event. The Dutch side trailed the LaLiga giants 3-0 heading into the final stages at the Camp Nou on a ...
Apple Unveils A20 Pro as First 2nm Smartphone Chip
Apple today revealed the A20 Pro chip in the iPhone 18 Pro and iPhone 18 Pro Max, built on a brand new architecture using 2nm process technology. Apple described the A20 Pro as "an exceptional chip that sets a new bar for mobile computing". The chip has a 6-core CPU design with two new super cores that Apple says are up to 20% faster, calling them "desktop class" and "the fastest in any smartphone," alongside four new efficiency cores.
RWJBarnabas Health Opens New Food Farmacy at Monmouth Medical Center
RWJBarnabas Health and Monmouth Medical Center (MMC) today celebrated the grand opening of the system’s sixth Food Farmacy to provide patients with nutritious foods and individualized nutrition counseling from registered dietitians to support long-term health and well-being.
Serco appoints second CEO in 12 months
Barbara Supplee will become CEO of Serco North America on Sept. 28, succeeding Michael LaRouche, who served less than a year.
A Medicare policy designed to encourage certain business arrangements produced unexpected results
The exclusion bar can be for the rest of your lifetime or for several years, but it effectively halts your ability to participate," said Alice Harris.
Allina Health doctors file 10-day strike notice
MPR News host Cathy Wurzer spoke with Dr. Saul Singh, bargaining team member for the Doctors Council SEIU, about the strike notice.
Barcelona vs Feyenoord, Champions League: TV & Streaming, Live Thread
Join us for the first Barcelona European adventure of the season!
Your Holiday Shopping Season Playbook: What to Do Now - Small Business & Entrepreneurship Council
By Barbara Weltman – The National Retail Federation (NRF) says the holiday shopping season runs from November 1 through December 31. Last year, an NRF survey found that 42% of consumers planned to begin holiday shopping before November. Will this year be different? And what will consumers on average spend? Last year, sales were strong, surpassing the prior […]
Blizzard Workers Ratify Union Contract With Microsoft
Blizzard's many disparate unions are also being condensed into three groups for ease of future bargaining
New ownership announced at troubled football club
A club spokesperson says they are excited to embark on a new chapter.
Southern Maryland nonprofit fills financial gaps for mental health resources
Over the last 25 years, Jennifer Voorhaar of Charlotte Hall has seen how financial barriers can prevent people from prioritizing their mental health.
Oil rises past $100 a barrel after latest wave of Middle East attacks
The average price for a gallon of regular gasoline ticked up 7 cents overnight to hit $4.22, according to AAA
2une In Previews: LASM's 41st annual gala brings live entertainment, open bars, new art to Baton Rouge
2une In Previews: LASM's 41st annual gala brings live entertainment, open bars, new art to Baton Rouge
Sportsman’s Alliance of Maine endorses Collins for U.S. Senate
The endorsement for Collins comes as the campaigns barrel toward the Nov. 3 election in one of the most highly anticipated Senate races in the country.
Eberl reveals Bayern explored move for Barcola before Liverpool switch
Bayern Munich were linked with a move for Bradley Barcola in the past, when he was still playing for Paris Saint-Germain, but ultimately chose not to pursue their interest.In an interview with Sport B...
Jaguars reporter highlights potential concern for 2026 season
With the Jacksonville Jaguars about to embark on the 2026 NFL season, what is the biggest concern surrounding this year's team?
This week in Santa Cruz County business: Paystand branches into AI agents; court hearing for former Scotts Valley executive; Barilla snaps up Goodles
In this week's survey of local business, Jessica M. Pasko reports on the rollout of a new AI tool for Santa Cruz-based fintech company Paystand, notes a court date for a former executive of Scotts Valley's Ambient Photonics and runs down other numbers, names and dates to know.
Becky G expands her block in new album ‘Baraja Bendita’
LOS ANGELES — This past February, Becky G was decked in a tiger-print Roberto Cavalli coat, preening for photos on the streets of Milan: a 13-hour flight away from LAX,
Becky G expands her block in new album ‘Baraja Bendita’
LOS ANGELES — This past February, Becky G was decked in a tiger-print Roberto Cavalli coat, preening for photos on the streets of Milan: a 13-hour flight away from LAX,
A rare thing in American politics may happen in Rhode Island on Wednesday
Gov. Dan McKee barely beat Helena Foulkes in 2022. For Wednesday’s rematch, the former CVS executive has outraised him and appears well positioned to win.
Barcelona’s Gabriel Jesus has Champions League score to settle
The striker is yet to taste glory in the competition.
We Need to Have a Conversation About Angel Reese
Angel Reese gets treated like a superstar. But are we sure she actually is one? Nobody can deny the rebounding. Nobody can deny the production. Reese is averaging 16.1 points and 12.4 rebounds this season, which is objectively impressive. But the WNBA is becoming increasingly loaded with elite players, and the bar for being called…
Business After Hours Sponsored by Earnest Consulting
Local professionals can connect during One SouthCoast Chamber’s September Business After Hours, Thursday, Sept. 24, from 5 to 7 p.m., at Cisco Kitchen & Bar, 1482 E. Rodney French Blvd., […]
Barcelona vs Feyenoord – Match preview and team news
Barcelona will aim to register their fifth straight victory this season when they kick off their UEFA Champions League campaign on Wednesday against Feyenoord at the Camp Nou.Barcelona vs Feyenoord �...
Barcelona vs Feyenoord – Predicted lineup and team news
Barcelona will be chasing a fifth consecutive win of the season as they begin their UEFA Champions League journey on Wednesday, hosting Feyenoord at the Camp Nou.FC Barcelona arrive in the competition...
A Marine Science Michelangelo?
Angelique Allen merges ocean art and octopus neuroscience at Santa Barbara Sea Glass & Ocean Arts Festival.
Revolut takes aim at business banking with FTSE 250 companies
Fintech’s business division has a target of 1mn customers globally by 2027
NASA X-59 explainer: Science of sonic booms
The most common misconception about sonic booms is that they’re just the sound created at the moment when an aircraft “breaks the sound barrier.”
AJ Barner practiced fully on Tuesday
AJ Barner is set to play in Week 1 against the New England Patriots.
Trump plans to ban imports of some Canadian dairy, alcohol
WASHINGTON — The United States escalated its trade war with Canada, moving to block imports of some alcoholic beverages, dairy products and motorcycles, as well as seeking to bar Canadian
Meet the Lehigh Valley's newest political bosses
Northampton County Democratic Chair Baron Vanderburg and Lehigh County Republican Committee Chair George Rivera want to change the course of politics in the Lehigh Valley.
Pomona Cafe and Wine Bar Gets Green Light for Entertainment
Pomona Cafe and Wine Bar has received approval for an entertainment license. The Select Board unanimously approved Pomona’s entertainment license application as part of the consent agenda at Tuesday’s meeting....
Logan Health primary care providers sign no-confidence vote
Logan Health primary care providers are raising concerns about leadership, signing a vote of no confidence.The vote comes after months of bargaining between Log
Mass. sues Trump admin over efforts to bar trans health care
The lawsuit comes amid growing unease around gender-affirming care for minors in the state
49ers Predicted to Bring Back $88 Million Super Bowl Champion
The Athletic's Matt Barrows predicts the San Francisco 49ers will bring back an $88 million edge rusher. The post 49ers Predicted to Bring Back $88 Million Super Bowl Champion appeared first on HEAVY.
Group of bikini baristas win nearly $2M in legal battle
Former bikini baristas at five coffee stands in the Puget Sound region say they were paid below minimum wage and forced to turn over earnings to keep up with strict
Business Aviation Insight. Reassessing Large-Cabin Value After the Falcon 900LX’s Final Delivery Year
Challenger 650 – Photo Credit: Bombardier The Falcon 900LX and Challenger 650 sit at opposite ends of a large-cabin segment that, on 2026 data, now spans nearly $19 million in …
CONFIRMED lineups: Real Madrid vs Inter Milan, 2026 Champions League
Real Madrid have published their starting lineup for the upcoming match against Inter Milan in the Champions League. STARTING LINEUPS: Real Madrid starting XI: Courtois; Dumfries, Konaté, Huijsen, Cucurella; Valverde, Trent; Brahim, Bellingham, Vinicius; Mbappé. Inter Milan starting XI (TBC): Martínez; Bisseck, Stones, Bastoni; Luis Henrique, Barella, Calhanoglu, Jones, Carlos Ausgusto; Lautaro, Thuram. HOW TO […]
This Russian River Home on the Market Was Built for Entertainment
Built in 1994 and rooted in traditional style, the home includes a pool, outdoor kitchen, island-style bar, wine cellar and vineyard.
Health: The Fight For The Health Of 9/11 First Responders
A quarter century after 9/11, the health of those who responded to the attacks continues to be affected.Some 3,000 people died across three locations that day. An estimated 400,000 people were exposed to toxic contaminants and risked physical injury in the hours and days that followed. That’s according to data from the Centers for Disease Control and Prevention.Since the dust and debris have settled, more than 96,000 have been diagnosed with physical and mental health conditions related to 9/11.In 2010, President Barack Obama signed the James Zadroga 9/11 Health and Compensation Act, establishing the World Trade Center Health Program and reopening the 9/11 Victims Compensation Fund. Today, more than 150,000 people are enrolled in the program.But that program wouldn’t exist without the advocacy of survivors and first responders who put their bodies and lives on the line following the attacks. How did that fight for care unfold?For more information about the Rutgers WTC Health Program, click here. And to learn more about applying, click here.Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Growth in every postcode: good politics, dubious economics
The UK government would be better off backing clusters and widening access to opportunity
Dan Campbell Reveals Detroit Lions Guard Plan for Week 1
Dan Campbell is keeping Detroit's left guard competition alive entering Week 1. Christian Mahogany and Ben Bartch will split first-team practice reps, and both could see action against New Orleans.
German Politics Are Rocked After Election. What the Markets Are Keeping an Eye On.
German markets will focus on whether the nationalist’s party win forces the chancellor to alter structural reforms that appeal to investors.
Disney On Ice coming to Mohegan Arena next year
WILKES-BARRE TWP., LUZERNE COUNTY (WBRE/WYOU) — A new Disney On Ice production is skating into the Mohegan Arena in January 2027. Disney On Ice presents Spotlight Magic! Coming to the Mohegan Arena at...
“The View” pays powerful tribute to Barbara Walters in emotional season 30 premiere: ‘This is that show’ she envisioned
Whoopi Goldberg spoke about how each of the six current cohosts fulfills the late Walters’ desire to highlight the perspectives of an eclectic group of women.
Scientists call for joint efforts to preserve nomadic heritage
At the International Scientific and Practical Conference “Cultural Heritage of the World’s Nomadic Peoples: Preservation, Study, and Development”, scholars and experts from 23 countries urged unified action to safeguard the cultural diversity of nomadic peoples and ensure traditions remain alive for future generations, Qazinform News Agency cites Kabar.
Oil prices surge back toward $100: What market pros are saying
Oil is creeping back toward $100 a barrel, fueling a Labor Day record for US gas prices over the long weekend.
Penn State Dairy Barns Made Animal Science Student ‘Feel at Home'
UNIVERSITY PARK, Pa. — Three years of working in Penn State’s Dairy Barns have been impactful for Hannah Mansfield, a spring 2026 College of Agricultural Sciences graduate who is...
AMID POLITICAL AD BOMBARDMENT, SAUSAGE DECLARES ITS CANDIDACY… FOR DINNER
As political advertising floods screens, phones and mailboxes ahead of the 2026 midterm elections, Johnsonville is entering the race for Dinner 2026 with a candidate of its own: Sausage. Backed by new research commissioned by Johnsonville suggesting Americans are overwhelmed by both politics and meal planning, Sausage is running on a core promise to simplify dinner decisions.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Trump’s Bombardier threat puts aerospace supply chain at risk
U.S. President Donald Trump has threatened to ban the sale of aircraft from Canada’s Bombardier unless it manufactures planes in the U.S. In response, the maker of private jets noted that many components for its planes, including the wings, are produced in the U.S. and its supply chain relies heavily on U.S. companies. Since Canada-U.S. […]
How Is Hilton Worldwide's Stock Performance Compared to Other Leisure and Entertainment Stocks?
Hilton Worldwide has outperformed the Leisure and Entertainment industry over the past year, and analysts are cautiously optimistic about the stock’s prospects.
Trump threatens Canadian jetmaker Bombardier
U.S. President Donald Trump has threatened to ban the sale of aircraft from Canada’s Bombardier unless it manufactures planes in the United States
Penélope Cruz and Javier Bardem Say 'It's Impossible' Not to Talk Politics After Starring in Projects Like 'Bunker'
Penélope Cruz and Javier Bardem agree that "it's impossible" not to talk politics as actors when they're starring in timely stories
Commentary: Sadly, the promise of special education still hasn’t been realized
Significant barriers prevent students with disabilities from reaching the goal of preparing them for the transition to adulthood and independent living.
Javier Bardem, Penelope Cruz Tackle Politics at 'Bunker' Presser
Bardem's wife, Penelope Cruz, admitted she worries about the role of women today as the couple joined director Florian Zeller and co-stars Stephen Graham, Paul Dano and Paul Schwarzenegger ahead of the Venice premiere of 'Bunker.'